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GENE - TERM ANNOTATION REPORT

RGD ID: 10256
Species: Mus musculus
RGD Object: Gene
Symbol: C3
Name: complement component 3
Acc ID: DOID:9002165
Term: Diabetic Nephropathies
Definition: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
Definition Source(s): MESH:D003928
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
C3 IEP 7183082RGDassociated with Diabetes Mellitus, Type 1; protein:increased expression:kidney: 
C3 ISOC3 (Rattus norvegicus)11040807RGDassociated with Diabetes Mellitus, Type 2 
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