GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | C3 | affects expression | EXP | | 6480464 | CTD | Estradiol affects the expression of C3 mRNA | PMID:15598610 | C3 | decreases activity | EXP | | 6480464 | CTD | Estradiol results in decreased activity of C3 protein | PMID:18615583 | C3 | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of C3 mRNA; Estradiol results in increased expression of C3 protein | PMID:11390168 PMID:12370124 PMID:15289156 PMID:16985261 PMID:19484750 | C3 | multiple interactions | EXP | | 6480464 | CTD | Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of C3 mRNA] | PMID:16977382 | C3 | affects expression | ISO | C3 (Rattus norvegicus) | 6480464 | CTD | Estradiol affects the expression of C3 mRNA | PMID:18790044 PMID:24777823 | C3 | decreases expression | ISO | C3 (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of C3 mRNA | PMID:31646340 | C3 | increases expression | ISO | C3 (Rattus norvegicus) | 6480464 | CTD | Estradiol results in increased expression of C3 mRNA; Estradiol results in increased expression of C3 protein | PMID:11086226 PMID:15456929 PMID:15458795 PMID:16522720 PMID:20381596 PMID:22127542 PMID:27463640 PMID:32145629 | C3 | increases expression | ISO | C3 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of C3 mRNA | PMID:18191855 PMID:19619570 PMID:22989670 PMID:25321415 PMID:31614463 | C3 | multiple interactions | ISO | C3 (Rattus norvegicus) | 6480464 | CTD | 11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol inhibits the reaction [Estradiol results in increased expression of C3 mRNA]; [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of C3 mRNA; Genistein inhibits the reaction [Estradiol affects the expression of C3 mRNA]; Progesterone inhibits the reaction [Estradiol affects the expression of C3 mRNA] | PMID:17049845 PMID:22127542 PMID:24777823 PMID:32741896 | C3 | multiple interactions | ISO | C3 (Homo sapiens) | 6480464 | CTD | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of C3 mRNA; [Estradiol co-treated with TGFB1 protein] results in decreased expression of C3 mRNA; Estradiol inhibits the reaction [Fulvestrant results in decreased expression of C3 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of C3 mRNA] | PMID:19619570 PMID:30165855 PMID:31646340 | | ||||||||||||||||||||||
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