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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10235
Species: Mus musculus
RGD Object: Gene
Symbol: Bdnf
Name: brain derived neurotrophic factor
Acc ID: CHEBI:63041
Term: manganese(II) chloride
Definition: An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure.
Chemical ID: MESH:C025340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnfdecreases expressionEXP 6480464CTDmanganese chloride results in decreased expression of BDNF mRNAPMID:25698507
Bdnfincreases expressionISOBdnf (Rattus norvegicus)6480464CTDmanganese chloride results in increased expression of BDNF mRNAPMID:28801915
Bdnfincreases methylationISOBdnf (Rattus norvegicus)6480464CTDmanganese chloride results in increased methylation of BDNF genePMID:28801915
Bdnfmultiple interactionsISOBdnf (Rattus norvegicus)6480464CTD[manganese chloride results in increased abundance of Manganese] which results in decreased expression of BDNF protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]PMID:30951808
Bdnfmultiple interactionsISOBDNF (Homo sapiens)6480464CTD[manganese chloride results in increased abundance of Manganese] which results in decreased expression of BDNF proteinPMID:32659473
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