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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10235
Species: Mus musculus
RGD Object: Gene
Symbol: Bdnf
Name: brain derived neurotrophic factor
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnfdecreases expressionEXP 6480464CTDRotenone results in decreased expression of BDNF proteinPMID:36774383
Bdnfmultiple interactionsEXP 6480464CTDBDNF protein affects the reaction [PITX3 protein results in decreased susceptibility to Rotenone]; oleuropein affects the reaction [Rotenone results in decreased expression of BDNF protein]PMID:18646205 PMID:36774383
Bdnfdecreases expressionISOBdnf (Rattus norvegicus)6480464CTDRotenone results in decreased expression of BDNF mRNA; Rotenone results in decreased expression of BDNF proteinPMID:17442543 PMID:23189969 PMID:25446674 PMID:28238857 PMID:28389404 PMID:35104487 PMID:36706892
Bdnfincreases expressionISOBDNF (Homo sapiens)6480464CTDRotenone results in increased expression of BDNF mRNAPMID:29955902
Bdnfmultiple interactionsISOBdnf (Rattus norvegicus)6480464CTDApigenin inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]; asiaticoside inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]; echinacoside inhibits the reaction [Rotenone results in decreased expression of BDNF protein]; Haloperidol inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]; Risperidone inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]; Roflumilast inhibits the reaction [Rotenone results in decreased expression of BDNF protein]; saxagliptin inhibits the reaction [Rotenone results in decreased expression of BDNF protein]; staurosporine aglycone inhibits the reaction [echinacoside inhibits the reaction [Rotenone results in decreased expression of BDNF protein]]PMID:17442543 PMID:23189969 PMID:25446674 PMID:28238857 PMID:28389404 PMID:36706892
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