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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10230
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2
Name: B cell leukemia/lymphoma 2
Acc ID: CHEBI:67521
Term: (-)-gambogic acid
Definition: A pyranoxanthone that has formula C38H44O8.
Chemical ID: MESH:C052659
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2affects expressionISOBCL2 (Homo sapiens)6480464CTDgambogic acid affects the expression of BCL2 proteinPMID:19433130
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDgambogic acid results in decreased expression of BCL2 mRNAPMID:15968715 PMID:19084572 PMID:33533530
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Verapamil co-treated with gambogic acid] results in decreased expression of BCL2 protein; Fluorouracil promotes the reaction [gambogic acid results in decreased expression of BCL2 mRNA]PMID:19084572 PMID:24373880
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