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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10230
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2
Name: B cell leukemia/lymphoma 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of BCL2 mRNA; Dexamethasone results in decreased expression of BCL2 proteinPMID:16644695 PMID:30878453 PMID:7517174
Bcl2decreases response to substanceEXP 6480464CTDBCL2 protein results in decreased susceptibility to DexamethasonePMID:19997594
Bcl2increases expressionEXP 6480464CTDDexamethasone results in increased expression of BCL2 mRNAPMID:21041162
Bcl2multiple interactionsEXP 6480464CTD[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of BCL2 protein; BCL2 gene inhibits the reaction [Dexamethasone results in decreased activity of CAT protein]; BCL2 gene inhibits the reaction [Dexamethasone results in decreased activity of NQO1 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of BCL2 mRNA]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of BCL2 protein]; naringin inhibits the reaction [Dexamethasone results in decreased expression of BCL2 protein]PMID:11751460 PMID:16644695 PMID:17180084 PMID:30878453 PMID:32687258
Bcl2decreases expressionISOBcl2 (Rattus norvegicus)6480464CTDDexamethasone results in decreased expression of BCL2 mRNA; Dexamethasone results in decreased expression of BCL2 proteinPMID:19080409 PMID:30506661
Bcl2decreases response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein results in decreased susceptibility to DexamethasonePMID:16505121
Bcl2increases expressionISOBcl2 (Rattus norvegicus)6480464CTDDexamethasone results in increased expression of BCL2 proteinPMID:11319611
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDDexamethasone results in increased expression of BCL2; Dexamethasone results in increased expression of BCL2 proteinPMID:11319611 PMID:21244764
Bcl2increases response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein results in increased susceptibility to DexamethasonePMID:10200551
Bcl2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTDDexamethasone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2 protein]; fludarabine inhibits the reaction [Dexamethasone results in decreased expression of BCL2 protein]PMID:16407456 PMID:30506661
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Doxorubicin co-treated with Dexamethasone co-treated with Vincristine co-treated with Cytarabine co-treated with Mercaptopurine co-treated with Methotrexate co-treated with Cyclophosphamide co-treated with Enzymes and Coenzymes] results in increased expression of BCL2 protein; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of BCL2 mRNA; [oblimersen co-treated with Thalidomide co-treated with Dexamethasone] results in decreased expression of BCL2 mRNA; [oblimersen co-treated with Thalidomide co-treated with Dexamethasone] results in decreased expression of BCL2 protein; Dexamethasone inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; Dexamethasone inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Mifepristone inhibits the reaction [Dexamethasone results in increased expression of BCL2]; Mycophenolic Acid inhibits the reaction [BCL2 protein results in decreased susceptibility to Dexamethasone]PMID:15867202 PMID:16505121 PMID:21182165 PMID:21244764 PMID:21420233 PMID:21940343 PMID:28628672
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