GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2 | affects expression | EXP | | 6480464 | CTD | bisphenol A affects the expression of BCL2 mRNA; bisphenol A affects the expression of BCL2 protein | PMID:26746108 PMID:33509759 | Bcl2 | decreases activity | EXP | | 6480464 | CTD | bisphenol A results in decreased activity of BCL2 protein | PMID:33485121 | Bcl2 | decreases expression | EXP | | 6480464 | CTD | bisphenol A results in decreased expression of BCL2 mRNA; bisphenol A results in decreased expression of BCL2 protein | PMID:11906184 PMID:22269103 PMID:23900028 PMID:24905940 PMID:24909818 PMID:26512966 PMID:28393075 PMID:28641223 PMID:31201698 PMID:31263496 PMID:32407858 PMID:32488702 PMID:33485121 PMID:34186417 PMID:36451259 PMID:36858637 PMID:38021376 | Bcl2 | increases expression | EXP | | 6480464 | CTD | bisphenol A results in increased expression of BCL2 mRNA; bisphenol A results in increased expression of BCL2 protein | PMID:23900028 PMID:23928317 PMID:24604882 PMID:24909818 PMID:25594700 PMID:26049153 PMID:32353937 | Bcl2 | multiple interactions | EXP | | 6480464 | CTD | 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [bisphenol A results in decreased activity of BCL2 protein]; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in decreased expression of BCL2 protein; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of BCL2 protein; [Streptozocin co-treated with bisphenol A] results in increased expression of BCL2 mRNA; Acetylcysteine inhibits the reaction [bisphenol A results in decreased activity of BCL2 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [bisphenol A results in decreased activity of BCL2 protein]; bisphenol A promotes the reaction [Streptozocin results in decreased expression of BCL2 protein]; coenzyme Q10 inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Drugs, Chinese Herbal inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; Ginsenosides inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; KN 62 inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; oligomycin A inhibits the reaction [bisphenol A results in increased expression of BCL2 protein]; U 0126 inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; VDAC1 promotes the reaction [bisphenol A results in decreased expression of BCL2 protein]; W 7 inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein] | PMID:22269103 PMID:24781736 PMID:24905940 PMID:24909818 PMID:32488702 PMID:33485121 PMID:34186417 PMID:35739755 PMID:36858637 PMID:37364641 | Bcl2 | affects expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | bisphenol A affects the expression of BCL2 mRNA; bisphenol A affects the expression of BCL2 protein | PMID:24156707 PMID:31916403 | Bcl2 | affects methylation | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | bisphenol A affects the methylation of BCL2 gene | PMID:31601247 | Bcl2 | decreases expression | ISO | Bcl2 (Rattus norvegicus) | 6480464 | CTD | bisphenol A results in decreased expression of BCL2; bisphenol A results in decreased expression of BCL2 mRNA; bisphenol A results in decreased expression of BCL2 protein | PMID:16909604 PMID:23328667 PMID:24768697 PMID:25181051 PMID:25381574 PMID:25461564 PMID:25963729 PMID:27189055 PMID:27539358 PMID:27925325 PMID:30228064 PMID:32153214 PMID:32714078 PMID:33582411 PMID:35465754 PMID:35648353 PMID:35699857 PMID:35887390 PMID:38006930 | Bcl2 | decreases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased expression of BCL2 mRNA; bisphenol A results in decreased expression of BCL2 protein | PMID:21277958 PMID:26363213 PMID:31400064 PMID:31675489 PMID:33039870 PMID:35439536 PMID:38006930 | Bcl2 | increases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | bisphenol A analog results in increased expression of BCL2 mRNA; bisphenol A results in increased expression of BCL2 mRNA; bisphenol A results in increased expression of BCL2 protein | PMID:15461258 PMID:19270784 PMID:19796866 PMID:26363202 PMID:27685785 PMID:28426875 PMID:32387340 | Bcl2 | increases methylation | ISO | Bcl2 (Rattus norvegicus) | 6480464 | CTD | bisphenol A results in increased methylation of BCL2 gene | PMID:28505145 | Bcl2 | multiple interactions | ISO | Bcl2 (Rattus norvegicus) | 6480464 | CTD | 18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in decreased expression of BCL2]; [bisphenol A co-treated with 4-nonylphenol] results in decreased expression of BCL2 mRNA; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]]; Lycopene inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; NR4A1 protein inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]] | PMID:25963729 PMID:30228064 PMID:32153214 PMID:33582411 PMID:35465754 PMID:35699857 | Bcl2 | multiple interactions | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | [bisphenol A co-treated with 4-cumylphenol] results in increased expression of BCL2 mRNA; [bisphenol A co-treated with Fulvestrant] results in decreased methylation of BCL2 gene; [bisphenol A results in increased activity of ESR1 protein] which results in increased expression of BCL2 mRNA; [Doxorubicin co-treated with bisphenol A] results in increased expression of BCL2 protein; [naringenin co-treated with bisphenol A] results in increased expression of BCL2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BCL2 mRNA; benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [bisphenol A results in increased expression of BCL2 protein] | PMID:19270784 PMID:19796866 PMID:22403704 PMID:31601247 PMID:31916403 PMID:35439536 PMID:36235125 | | ||||||||||||||||||||||
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