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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10230
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2
Name: B cell leukemia/lymphoma 2
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of BCL2 mRNA; Arsenic Trioxide results in decreased expression of BCL2 proteinPMID:10721769 PMID:21565247 PMID:24157283 PMID:25787108 PMID:28587418 PMID:32781346 PMID:33603344 PMID:33846815 PMID:34333357 PMID:35317438 PMID:36707890 PMID:9716575 PMID:9734658
Bcl2increases cleavageEXP 6480464CTDArsenic Trioxide results in increased cleavage of BCL2 proteinPMID:15761769
Bcl2increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of BCL2 proteinPMID:10712780
Bcl2multiple interactionsEXP 6480464CTD18alpha,20beta-hydroxy-11-oxo-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranurosyl-alpha-D-glucopyranosiduronate magnesium tetrahydrate inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; [Genistein co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; Arsenic Trioxide promotes the reaction [Drugs, Chinese Herbal results in decreased expression of BCL2 protein]; baicalin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; Drugs, Chinese Herbal promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; MIR34A affects the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; Propranolol inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]PMID:21078540 PMID:28587418 PMID:33603344 PMID:33846815 PMID:34333357 PMID:35317438 PMID:36707890
Bcl2affects expressionISOBcl2 (Rattus norvegicus)6480464CTDArsenic Trioxide affects the expression of BCL2 mRNA; Arsenic Trioxide affects the expression of BCL2 proteinPMID:12725324 PMID:18618274
Bcl2affects expressionISOBCL2 (Homo sapiens)6480464CTDArsenic Trioxide affects the expression of BCL2 proteinPMID:12962562 PMID:16010437 PMID:16867262 PMID:18357729 PMID:20200477
Bcl2affects foldingISOBCL2 (Homo sapiens)6480464CTDArsenic Trioxide affects the folding of BCL2 proteinPMID:20403207
Bcl2affects response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein affects the susceptibility to Arsenic TrioxidePMID:10648417 PMID:18726487
Bcl2decreases expressionISOBcl2 (Rattus norvegicus)6480464CTDArsenic Trioxide results in decreased expression of BCL2 mRNA; Arsenic Trioxide results in decreased expression of BCL2 proteinPMID:19260322 PMID:21145380 PMID:23201927 PMID:23542815 PMID:28391263 PMID:29297235 PMID:29610575 PMID:30551535 PMID:32096187 PMID:32919218 PMID:32920515 PMID:33173984 PMID:34037972 PMID:35195477
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of BCL2; Arsenic Trioxide results in decreased expression of BCL2 mRNA; Arsenic Trioxide results in decreased expression of BCL2 proteinPMID:10340400 PMID:10850458 PMID:11027660 PMID:11135700 PMID:11589617 PMID:11775218 PMID:11780464 PMID:12429934 PMID:12490120 PMID:12845720 PMID:12859871 PMID:12883267 PMID:12975549 PMID:14703445 PMID:15352174 PMID:15493360 PMID:15622746 PMID:15844663 PMID:16105982 PMID:16166054 PMID:16818652 PMID:16904648 PMID:18349030 PMID:18539383 PMID:19489279 PMID:19695276 PMID:19771260 PMID:20219070 PMID:20435036 PMID:20458559 PMID:20723295 PMID:21061466 PMID:21418039 PMID:21473291 PMID:21594580 PMID:22519831 PMID:22949821 PMID:22959511 PMID:23382965 PMID:23700110 PMID:23721794 PMID:23725168 PMID:23851143 PMID:23861973 PMID:23980369 PMID:24466103 PMID:24944602 PMID:24993472 PMID:25110043 PMID:25174355 PMID:25335113 PMID:25416439 PMID:25945059 PMID:26772155 PMID:30091188 PMID:30316766 PMID:30333888 PMID:30472098 PMID:31079498 PMID:31205918 PMID:32642412 PMID:36442592 PMID:8704214 PMID:9129041 PMID:9716575
Bcl2decreases response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein results in decreased susceptibility to Arsenic Trioxide; BCL2 results in decreased susceptibility to Arsenic TrioxidePMID:11775218 PMID:12168106 PMID:16007134 PMID:16904648 PMID:17374990 PMID:18412143 PMID:22590507
Bcl2increases cleavageISOBCL2 (Homo sapiens)6480464CTDArsenic Trioxide results in increased cleavage of BCL2 proteinPMID:11739184
Bcl2increases degradationISOBCL2 (Homo sapiens)6480464CTDArsenic Trioxide results in increased degradation of BCL2 proteinPMID:19468689
Bcl2increases expressionISOBcl2 (Rattus norvegicus)6480464CTDArsenic Trioxide results in increased expression of BCL2 mRNAPMID:17487067
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of BCL2 mRNA; Arsenic Trioxide results in increased expression of BCL2 proteinPMID:16966277 PMID:18022205 PMID:19208092 PMID:25972196 PMID:27430728 PMID:34303041
Bcl2increases phosphorylationISOBCL2 (Homo sapiens)6480464CTDArsenic Trioxide results in increased phosphorylation of BCL2 proteinPMID:12181429 PMID:18412143 PMID:34303041
Bcl2increases response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 mutant form results in increased susceptibility to Arsenic TrioxidePMID:14642526
Bcl2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]]; [alpha-Tocopherol co-treated with Ascorbic Acid] inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; HTS 466284 inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; Phloretin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 mRNA]; salvianolic acid A inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; salvianolic acid B inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; Taurine inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; trans-sodium crocetinate inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]PMID:17487067 PMID:23201927 PMID:23542815 PMID:28391263 PMID:29297235 PMID:30551535 PMID:32919218 PMID:32920515 PMID:33173984 PMID:34037972 PMID:35195477
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of BCL2 protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Arsenic Trioxide affects the localization of BCL2 protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 protein]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2]; 4-amino-1,8-naphthalimide inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 protein]; [Arsenic Trioxide co-treated with Aprepitant] results in decreased expression of BCL2 mRNA; [Arsenic Trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in decreased expression of BCL2 protein; [Arsenic Trioxide co-treated with BCL2 mutant form] results in increased expression of BCL2 protein; [Arsenic Trioxide co-treated with Bortezomib] results in decreased expression of BCL2 mRNA; [Arsenic Trioxide co-treated with Curcumin] affects the expression of BCL2 protein; [Arsenic Trioxide co-treated with Doxorubicin co-treated with Magnetite Nanoparticles analog] affects the expression of BCL2 mRNA; [Arsenic Trioxide co-treated with Doxorubicin co-treated with Magnetite Nanoparticles analog] affects the expression of BCL2 protein; [Arsenic Trioxide co-treated with epigallocatechin gallate] results in decreased expression of BCL2 protein; [Arsenic Trioxide co-treated with NVP-BKM120] results in decreased expression of BCL2 mRNA; [Arsenic Trioxide co-treated with PML protein] results in decreased expression of BCL2; [Arsenic Trioxide results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BAX protein]; [BIBR 1532 co-treated with Arsenic Trioxide] affects the expression of BCL2 mRNA; [Bortezomib co-treated with Arsenic Trioxide] affects the expression of BCL2 protein; [Bortezomib co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [Curcumin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of BCL2 mRNA; [Genistein co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [Hydrogen Peroxide co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [MARVELD1 protein results in decreased susceptibility to Arsenic Trioxide] which results in increased expression of BCL2 protein; [paricalcitol co-treated with Arsenic Trioxide] results in decreased expression of BCL2; [pifithrin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of BCL2 mRNA; [Silybin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 mRNA; [tetraarsenic tetrasulfide co-treated with Arsenic Trioxide] results in decreased expression of BCL2 mRNA; [tetraarsenic tetrasulfide co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [Tretinoin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 mRNA; [Valproic Acid co-treated with Arsenic Trioxide] results in decreased expression of BCL2 mRNA; [Valproic Acid co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [Vorinostat co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Resveratrol results in decreased expression of BCL2 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of and affects the localization of BCL2 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of BCL2 protein]; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]]; Arsenic Trioxide inhibits the reaction [BCL2 protein binds to BAX protein binds to VDAC1 protein]; Arsenic Trioxide inhibits the reaction [BCL2 protein binds to BAX protein]; Arsenic Trioxide promotes the reaction [Genistein results in decreased expression of BCL2 protein]; Arsenic Trioxide promotes the reaction [Matrines results in decreased expression of BCL2 protein]; Arsenic Trioxide promotes the reaction [puerarin results in decreased expression of BCL2 mRNA]; Arsenic Trioxide promotes the reaction [Resveratrol results in decreased expression of BCL2 protein]; Arsenic Trioxide promotes the reaction [TGFB1 protein results in decreased expression of BCL2 protein]; Arsenic Trioxide results in decreased expression of and affects the localization of BCL2 protein; Arsenic Trioxide results in increased expression of and affects the localization of BCL2 protein; BCL2 inhibits the reaction [[Arsenic Trioxide co-treated with TNF protein] results in decreased expression of CFLAR protein]; BCL2 inhibits the reaction [[Arsenic Trioxide co-treated with TNF protein] results in increased activity of CASP8 protein]; BCL2 protein inhibits the reaction [[Arsenic Trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein]; BCL2 protein inhibits the reaction [[Arsenic Trioxide co-treated with Quercetin] results in increased cleavage of and results in increased activity of CASP8 protein]; BCL2 protein inhibits the reaction [Arsenic Trioxide inhibits the reaction [BCL2 protein binds to BAX protein]]; BCL2 protein inhibits the reaction [Arsenic Trioxide promotes the reaction [lonidamine results in increased cleavage of and results in increased activity of CASP9 protein]]; BCL2 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of MYC mRNA]; BCL2 protein inhibits the reaction [Arsenic Trioxide results in increased activity of BAX protein]; BCL2 protein inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [lonidamine promotes the reaction [Arsenic Trioxide results in increased cleavage of and results in increased activity of CASP9 protein]]; Cycloheximide inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 protein]; Dactinomycin inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 protein]; Dithiothreitol inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 protein]; Genistein promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; GH1 protein promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; HOMER3 protein affects the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; ID1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; MAPK14 mutant form inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of BCL2 protein]; MAPK8 mutant form inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of BCL2 protein]; MAPK9 mutant form inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of BCL2 protein]; MARVELD1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; Matrines promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; NVP-BKM120 promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of BCL2 protein]; Resveratrol promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; SB 203580 inhibits the reaction [Arsenic Trioxide affects the localization of BCL2 protein]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 mRNA]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 protein]; SB 203580 promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; Wortmannin inhibits the reaction [[Hydrogen Peroxide co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein]PMID:11775218 PMID:12168106 PMID:14642526 PMID:15142122 PMID:15735709 PMID:15781666 PMID:15894607 PMID:16818652 PMID:17374990 PMID:17673311 PMID:18022205 PMID:18359480 PMID:18412143 PMID:18718063 PMID:20219070 PMID:20377131 PMID:20416161 PMID:20471514 PMID:20723295 PMID:20950636 PMID:21078540 PMID:21889928 PMID:21969006 PMID:23700110 PMID:23725168 PMID:23851143 PMID:24126434 PMID:24377552 PMID:24738333 PMID:25110043 PMID:25815518 PMID:25972196 PMID:26110921 PMID:26772155 PMID:27189198 PMID:27430728 PMID:29274334 PMID:30012499 PMID:30145367 PMID:30316766 PMID:30472098 PMID:31079498 PMID:31205918 PMID:31539632 PMID:32645343 PMID:34303041 PMID:34675983 PMID:35030298 PMID:36352148
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