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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10216
Species: Homo sapiens
RGD Object: Gene
Symbol: ATP7A
Name: ATPase copper transporting alpha
Acc ID: CHEBI:63934
Term: bathocuproine disulfonic acid
Definition: A phenanthroline that consists of 1,10-phenanthroline bearing two methyl groups at position 2 and 9 as well as two 4-sulfophenyl groups at positions 4 and 7.
Chemical ID: MESH:C028559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ATP7Amultiple interactionsEXP 6480464CTD[Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]; bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]; cupric chloride inhibits the reaction [bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]]PMID:11092760 PMID:21242307
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