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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10198
Species: Mus musculus
RGD Object: Gene
Symbol: Atf3
Name: activating transcription factor 3
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf3increases expressionEXP 6480464CTDBortezomib results in increased expression of ATF3 proteinPMID:20830808
Atf3increases expressionISOAtf3 (Rattus norvegicus)6480464CTDBortezomib results in increased expression of ATF3 mRNA; Bortezomib results in increased expression of ATF3 proteinPMID:20830808
Atf3increases expressionISOATF3 (Homo sapiens)6480464CTDBortezomib results in increased expression of ATF3; Bortezomib results in increased expression of ATF3 mRNA; Bortezomib results in increased expression of ATF3 proteinPMID:17898295 PMID:20022965 PMID:21762082
Atf3increases response to substanceISOATF3 (Homo sapiens)6480464CTDATF3 results in increased susceptibility to BortezomibPMID:20022965
Atf3multiple interactionsISOATF3 (Homo sapiens)6480464CTD[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of ATF3 mRNA; ATF3 mutant form promotes the reaction [Bortezomib results in increased expression of PMAIP1 mRNA]PMID:20022965 PMID:25522274
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