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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10198
Species: Mus musculus
RGD Object: Gene
Symbol: Atf3
Name: activating transcription factor 3
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf3increases expressionEXP 6480464CTDAflatoxin B1 results in increased expression of ATF3 mRNAPMID:19770486
Atf3affects expressionISOATF3 (Homo sapiens)6480464CTDAflatoxin B1 affects the expression of ATF3 proteinPMID:20106945
Atf3increases expressionISOAtf3 (Rattus norvegicus)6480464CTDAflatoxin B1 results in increased expression of ATF3 mRNAPMID:15890375 PMID:25378103 PMID:33354967
Atf3increases expressionISOATF3 (Homo sapiens)6480464CTDAflatoxin B1 results in increased expression of ATF3 mRNAPMID:21641981 PMID:22100608 PMID:27153756 PMID:32607778
Atf3increases methylationISOATF3 (Homo sapiens)6480464CTDAflatoxin B1 results in increased methylation of ATF3 gene; Aflatoxin B1 results in increased methylation of ATF3 intronPMID:27153756 PMID:30157460
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