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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10187
Species: Mus musculus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:8863
Term: Riluzole
Definition: A benzothiazole that has formula C8H5F3N2OS.
Chemical ID: MESH:D019782
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Armultiple interactionsISOAR (Homo sapiens)6480464CTDChloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein alternative form]; Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein]; Riluzole promotes the reaction [AR protein binds to SQSTM1 protein]; Riluzole results in increased degradation of and results in decreased expression of AR protein; Riluzole results in increased degradation of and results in decreased expression of AR protein alternative form; Riluzole results in increased degradation of and results in decreased expression of AR protein mutant form; STF 083010 inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein]PMID:30280407
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