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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10187
Species: Mus musculus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:35298
Term: anthracene
Definition: An ortho-fused tricyclic hydrocarbon comprising three fused benzene rings.
Chemical ID: MESH:C034020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Armultiple interactionsISOAR (Homo sapiens)6480464CTD[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; anthracene inhibits the reaction [Androgens results in increased activity of AR protein]; anthracene inhibits the reaction [Metribolone results in increased activity of AR protein]PMID:18324785 PMID:28377212 PMID:30980910
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