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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10173
Species: Mus musculus
RGD Object: Gene
Symbol: Apoa1
Name: apolipoprotein A-I
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apoa1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of APOA1 mRNAPMID:27502578 PMID:29161229 PMID:32156529
Apoa1increases expressionEXP 6480464CTDbisphenol A results in increased expression of APOA1 mRNA; bisphenol A results in increased expression of APOA1 proteinPMID:18418863 PMID:22938446 PMID:30245210 PMID:34585602 PMID:38074096
Apoa1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA; [LDLR protein affects the susceptibility to bisphenol A] which affects the expression of APOA1 mRNA; bisphenol A inhibits the reaction [GW 4064 results in increased expression of APOA1 mRNA]; GW 4064 inhibits the reaction [bisphenol A results in increased expression of APOA1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA]PMID:30245210 PMID:31842455
Apoa1affects expressionISOApoa1 (Rattus norvegicus)6480464CTDbisphenol A affects the expression of APOA1 mRNAPMID:30903817
Apoa1affects expressionISOAPOA1 (Homo sapiens)6480464CTDbisphenol A affects the expression of APOA1 mRNAPMID:30903817
Apoa1decreases expressionISOApoa1 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of APOA1 mRNAPMID:25181051 PMID:30816183 PMID:32528016
Apoa1decreases expressionISOAPOA1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of APOA1 mRNAPMID:31842455
Apoa1increases expressionISOApoa1 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of APOA1 proteinPMID:22649256
Apoa1increases methylationISOApoa1 (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of APOA1 genePMID:28505145
Apoa1multiple interactionsISOApoa1 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Fructose] results in increased expression of APOA1 proteinPMID:23142792
Apoa1multiple interactionsISOAPOA1 (Homo sapiens)6480464CTD3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [bisphenol A results in decreased expression of APOA1 mRNA]; [IKBKB protein co-treated with bisphenol A] results in decreased expression of APOA1 mRNA; [MAP3K1 protein co-treated with bisphenol A] results in decreased expression of APOA1 mRNA; bisphenol A promotes the reaction [RELA protein binds to APOA1 promoter]; NFKBIB protein affects the reaction [bisphenol A results in decreased expression of APOA1 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [bisphenol A results in decreased expression of APOA1 mRNA]; U 0126 inhibits the reaction [bisphenol A results in decreased expression of APOA1 mRNA]PMID:31842455
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