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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10136
Species: Mus musculus
RGD Object: Gene
Symbol: Alb
Name: albumin
Acc ID: CHEBI:3750
Term: clofibrate
Definition: The ethyl ester of clofibric acid.
Chemical ID: MESH:D002994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Albmultiple interactionsEXP 6480464CTDClofibrate inhibits the reaction [[Fatty Acids, Nonesterified binds to ALB protein] which results in decreased expression of BCL2 protein]; Clofibrate inhibits the reaction [[Fatty Acids, Nonesterified binds to ALB protein] which results in decreased expression of BCL2L1 protein]; Clofibrate inhibits the reaction [[Fatty Acids, Nonesterified binds to ALB protein] which results in decreased expression of CAT protein]; Clofibrate inhibits the reaction [[Fatty Acids, Nonesterified binds to ALB protein] which results in decreased expression of PPARA mRNA]; Clofibrate inhibits the reaction [[Fatty Acids, Nonesterified binds to ALB protein] which results in decreased expression of SOD1 protein]; Clofibrate inhibits the reaction [[Fatty Acids, Nonesterified binds to ALB protein] which results in increased abundance of Fatty Acids, Nonesterified]; Clofibrate inhibits the reaction [[Fatty Acids, Nonesterified binds to ALB protein] which results in increased expression of ICAM1 mRNA]; Clofibrate inhibits the reaction [[Fatty Acids, Nonesterified binds to ALB protein] which results in increased expression of PTGS2 mRNA]; Clofibrate inhibits the reaction [[Fatty Acids, Nonesterified binds to ALB protein] which results in increased expression of TNF mRNA]; Clofibrate promotes the reaction [[Fatty Acids, Nonesterified binds to ALB protein] which results in increased expression of NFKBIA mRNA]; Clofibrate promotes the reaction [PPARA protein results in decreased susceptibility to [Fatty Acids, Nonesterified binds to ALB protein]]PMID:21338618
Albaffects abundanceISOAlb (Rattus norvegicus)6480464CTDALB protein affects the abundance of ClofibratePMID:18670166
Albincreases expressionISOAlb (Rattus norvegicus)6480464CTDClofibrate results in increased expression of ALB proteinPMID:16470657
Albincreases expressionISOALB (Homo sapiens)6480464CTDClofibrate results in increased expression of ALB proteinPMID:131008
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