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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10126
Species: Mus musculus
RGD Object: Gene
Symbol: Agtr2
Name: angiotensin II receptor, type 2
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtr2decreases expressionISOAgtr2 (Rattus norvegicus)6480464CTDDoxorubicin results in decreased expression of AGTR2 mRNAPMID:15331931
Agtr2multiple interactionsISOAgtr2 (Rattus norvegicus)6480464CTD[Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Cilazapril inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Losartan inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]PMID:15331931
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