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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10118
Species: Mus musculus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtmultiple interactionsEXP 6480464CTDNFE2L2 gene mutant form inhibits the reaction [sulforaphane inhibits the reaction [AGT protein modified form results in increased expression of CCN2 protein]]; NFE2L2 gene mutant form inhibits the reaction [sulforaphane inhibits the reaction [AGT protein modified form results in increased expression of NPPA protein]]; NFE2L2 gene mutant form inhibits the reaction [sulforaphane inhibits the reaction [AGT protein modified form results in increased expression of SERPINE1 protein]]; NFE2L2 gene mutant form inhibits the reaction [sulforaphane inhibits the reaction [AGT protein modified form results in increased expression of TNF protein]]; sulforaphane inhibits the reaction [AGT protein modified form results in decreased expression of CAT mRNA]; sulforaphane inhibits the reaction [AGT protein modified form results in decreased expression of CAT protein]; sulforaphane inhibits the reaction [AGT protein modified form results in decreased expression of HMOX1 mRNA]; sulforaphane inhibits the reaction [AGT protein modified form results in decreased expression of HMOX1 protein]; sulforaphane inhibits the reaction [AGT protein modified form results in decreased expression of NFE2L2 mRNA]; sulforaphane inhibits the reaction [AGT protein modified form results in decreased expression of NFE2L2 protein modified form]; sulforaphane inhibits the reaction [AGT protein modified form results in decreased expression of NFE2L2 protein]; sulforaphane inhibits the reaction [AGT protein modified form results in decreased expression of NQO1 mRNA]; sulforaphane inhibits the reaction [AGT protein modified form results in decreased expression of NQO1 protein]; sulforaphane inhibits the reaction [AGT protein modified form results in increased expression of CCN2 protein]; sulforaphane inhibits the reaction [AGT protein modified form results in increased expression of NPPA mRNA]; sulforaphane inhibits the reaction [AGT protein modified form results in increased expression of NPPA protein]; sulforaphane inhibits the reaction [AGT protein modified form results in increased expression of SERPINE1 protein]; sulforaphane inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 protein]; sulforaphane inhibits the reaction [AGT protein modified form results in increased expression of TNF protein]PMID:29353218
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