GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Agt | decreases expression | EXP | | 6480464 | CTD | Silicon Dioxide results in decreased expression of AGT protein alternative form | PMID:33007385 | Agt | increases expression | EXP | | 6480464 | CTD | Silicon Dioxide results in increased expression of AGT protein | PMID:33007385 | Agt | multiple interactions | EXP | | 6480464 | CTD | 2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid promotes the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; [Silicon Dioxide co-treated with 2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid] results in increased expression of AGT protein; [Silicon Dioxide co-treated with 7-Ala-angiotensin (1-7)] results in increased expression of AGT protein; ACE protein affects the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; ACE protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]; ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein] | PMID:33007385 | Agt | decreases expression | ISO | AGT (Homo sapiens) | 6480464 | CTD | Silicon Dioxide analog results in decreased expression of AGT mRNA | PMID:25895662 | Agt | increases expression | ISO | AGT (Homo sapiens) | 6480464 | CTD | Silicon Dioxide analog results in increased expression of AGT mRNA | PMID:23806026 | Agt | multiple interactions | ISO | Agt (Rattus norvegicus) | 6480464 | CTD | AGT protein modified form inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]; AGT protein modified form inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; AGT protein modified form inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; AGT protein modified form inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; AGT protein modified form inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]; AGT protein modified form inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]; AGT protein modified form inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein] | PMID:31181250 | | ||||||||||||||||||||||
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