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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10118
Species: Mus musculus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: CHEBI:27584
Term: aldosterone
Definition: A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
Chemical ID: MESH:D000450
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtincreases abundanceEXP 6480464CTDAGT protein modified form results in increased abundance of Aldosterone; AGT protein results in increased abundance of AldosteronePMID:25617244 PMID:26564064
Agtincreases secretionEXP 6480464CTDAGT protein results in increased secretion of AldosteronePMID:20175999
Agtmultiple interactionsEXP 6480464CTDAGT protein affects the reaction [SLC9A3 gene mutant form results in increased abundance of Aldosterone]PMID:26564064
Agtincreases abundanceISOAgt (Rattus norvegicus)6480464CTDAGT protein modified form results in increased abundance of Aldosterone; AGT protein results in increased abundance of AldosteronePMID:16788141 PMID:22452651 PMID:7588239
Agtincreases abundanceISOAGT (Homo sapiens)6480464CTDAGT protein modified form results in increased abundance of Aldosterone; AGT protein results in increased abundance of AldosteronePMID:18331727 PMID:6257467 PMID:8952583
Agtincreases expressionISOAgt (Rattus norvegicus)6480464CTDAldosterone results in increased expression of AGT protein alternative formPMID:18660453
Agtincreases secretionISOAGT (Homo sapiens)6480464CTDAGT protein results in increased secretion of AldosteronePMID:11549694 PMID:19371736 PMID:22798349
Agtmultiple interactionsISOAgt (Rattus norvegicus)6480464CTDAGT protein affects the reaction [DAB2 protein results in increased secretion of Aldosterone]; AGT protein alternative form promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]PMID:17303656 PMID:18660453
Agtmultiple interactionsISOAGT (Homo sapiens)6480464CTD[AGT co-treated with REN] results in increased abundance of Aldosterone; [Valsartan co-treated with benidipine] inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; benidipine inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]; Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]]; Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]; efonidipine inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]; KCNJ5 protein inhibits the reaction [AGT protein results in increased secretion of Aldosterone]; Losartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Mibefradil inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; naringin inhibits the reaction [AGT protein results in increased secretion of Aldosterone]; Raclopride inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]PMID:11549694 PMID:18331727 PMID:18679781 PMID:22798349 PMID:8952583
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