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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10118
Species: Mus musculus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: CHEBI:16113
Term: cholesterol
Definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.
Chemical ID: MESH:D002784
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtincreases expressionEXP 6480464CTDCholesterol results in increased expression of AGT proteinPMID:19028402
Agtmultiple interactionsEXP 6480464CTDCholesterol inhibits the reaction [irbesartan results in increased expression of AGT protein]PMID:19028402
Agtaffects abundanceISOAgt (Rattus norvegicus)6480464CTDAGT protein affects the abundance of CholesterolPMID:19109942
Agtmultiple interactionsISOAgt (Rattus norvegicus)6480464CTD[Puromycin Aminonucleoside co-treated with Cholesterol] results in increased expression of AGT mRNA; Hydralazine inhibits the reaction [AGT protein affects the abundance of Cholesterol]; Losartan inhibits the reaction [AGT protein affects the abundance of Cholesterol]PMID:12495295 PMID:19109942
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