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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10106
Species: Mus musculus
RGD Object: Gene
Symbol: Adrb1
Name: adrenergic receptor, beta 1
Acc ID: CHEBI:6343
Term: labetalol
Definition: A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.
Chemical ID: MESH:D007741
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adrb1affects bindingISOAdrb1 (Rattus norvegicus)6480464CTDLabetalol binds to ADRB1 proteinPMID:11483288 PMID:2462161
Adrb1decreases activityISOADRB1 (Homo sapiens)6480464CTDLabetalol results in decreased activity of ADRB1 proteinPMID:2567112
Adrb1increases activityISOADRB1 (Homo sapiens)6480464CTDLabetalol results in increased activity of ADRB1 proteinPMID:12761341
Adrb1multiple interactionsISOAdrb1 (Rattus norvegicus)6480464CTDLabetalol binds to and results in decreased activity of ADRB1 protein; Labetalol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Labetalol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]PMID:11425575 PMID:2462161
Adrb1multiple interactionsISOADRB1 (Homo sapiens)6480464CTD[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP; CGP 20712A inhibits the reaction [[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP]; CGP 20712A inhibits the reaction [Labetalol results in increased activity of ADRB1 protein]PMID:12761341
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