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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10073
Species: Homo sapiens
RGD Object: Gene
Symbol: ACP5
Name: acid phosphatase 5, tartrate resistant
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACP5multiple interactionsEXP 6480464CTD[Thalidomide co-treated with Dexamethasone] results in decreased expression of ACP5 proteinPMID:16079895
ACP5increases activityISOAcp5 (Rattus norvegicus)6480464CTDDexamethasone results in increased activity of ACP5 proteinPMID:27387537 PMID:28363435
ACP5increases expressionISOAcp5 (Mus musculus)6480464CTDDexamethasone results in increased expression of ACP5 mRNAPMID:21041162
ACP5multiple interactionsISOAcp5 (Rattus norvegicus)6480464CTDAlendronate inhibits the reaction [Dexamethasone results in increased activity of ACP5 protein]; caffeic acid phenethyl ester inhibits the reaction [Dexamethasone results in increased activity of ACP5 protein]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased activity of ACP5 protein]PMID:27387537 PMID:28363435
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