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VARIANT - TERM ANNOTATION REPORT

RGD ID: 10046173
Species: Homo sapiens
RGD Object: Variant
Symbol: CV189364
Name: NM_005477.3(HCN4):c.1840G>A (p.Glu614Lys)
Acc ID: DOID:9005141
Term: Ventricular Tachycardia
Definition: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).
Definition Source(s): MESH:D017180
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CV189364 IAGP 8554872ClinVarClinVar Annotator: match by term: Ventricular tachycardia

PMID:23861362, PMID:25741868, PMID:28492532
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.