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GENE - TERM ANNOTATION REPORT

13 Annotations Found.

An association has been curated linking Lep and obesity in Rattus norvegicus.        

  • The association was inferred from expression pattern (IEP)
    		•  
  • The annotation was made from Bhandari U, etal., Hum Exp Toxicol. 2010 Nov 12.
  • 2 additional annotations were made from Bhandari U, etal., Hum Exp Toxicol. 2010 Nov 12.
  • 797 RGD objects have been annotated to obesity  (DOID:9970)
  • 141 papers in RGD have been used to annotate Lep
  • Curation Notes: protein:increased expression:serum


    • An association has been curated linking Lep and obesity in Rattus norvegicus.        

  • The association was inferred from mutant phenotype (IMP)
    		•  
  • The annotation was made from Matheny M, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1254-61. Epub 2009 Sep 2.
  • 4 additional annotations were made from Matheny M, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1254-61. Epub 2009 Sep 2.
  • 797 RGD objects have been annotated to obesity  (DOID:9970)
  • 141 papers in RGD have been used to annotate Lep


    • An association has been curated linking Lep and obesity in Rattus norvegicus.        

  • The association was inferred from mutant phenotype (IMP)
    		•  
  • The annotation was made from Aizawa-Abe M, etal., Physiol Genomics. 2013 Sep 3;45(17):786-93. doi: 10.1152/physiolgenomics.00040.2013. Epub 2013 Jun 25.
  • 18 additional annotations were made from Aizawa-Abe M, etal., Physiol Genomics. 2013 Sep 3;45(17):786-93. doi: 10.1152/physiolgenomics.00040.2013. Epub 2013 Jun 25.
  • 797 RGD objects have been annotated to obesity  (DOID:9970)
  • 141 papers in RGD have been used to annotate Lep
  • Curation Notes: DNA:nonsense mutation:cds:


    • An association has been curated linking Lep and obesity in Rattus norvegicus.        

  • The association was inferred from mutant phenotype (IMP)
    		•  
  • The annotation was made from Vaira S, etal., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4.
  • 42 additional annotations were made from Vaira S, etal., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4.
  • 797 RGD objects have been annotated to obesity  (DOID:9970)
  • 141 papers in RGD have been used to annotate Lep


    • An association has been curated linking Lep and obesity in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
  • The annotation has been inferred from sequence orthology with LEP (Homo sapiens) [(IEA) inferred from electronic annotation]
  • 619 additional annotations were made from Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
  • 797 RGD objects have been annotated to obesity  (DOID:9970)
  • 141 papers in RGD have been used to annotate Lep


    • An association has been curated linking Lep and obesity in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Pelleymounter MA, etal., Science. 1995 Jul 28;269(5223):540-3.
  • The annotation has been inferred from sequence orthology with Lep (Mus musculus) [(IMP) inferred from mutant phenotype]
  • 2 additional annotations were made from Pelleymounter MA, etal., Science. 1995 Jul 28;269(5223):540-3.
  • 797 RGD objects have been annotated to obesity  (DOID:9970)
  • 141 papers in RGD have been used to annotate Lep


    • An association has been curated linking Lep and obesity in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Guo JJ, etal., Biochem Biophys Res Commun. 2005 Jul 1;332(2):602-8.
  • The annotation has been inferred from sequence orthology with LEP (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 2 additional annotations were made from Guo JJ, etal., Biochem Biophys Res Commun. 2005 Jul 1;332(2):602-8.
  • 797 RGD objects have been annotated to obesity  (DOID:9970)
  • 141 papers in RGD have been used to annotate Lep
  • Qualifier: no_association


    • An association has been curated linking Lep and obesity in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Ezenwaka CE, etal., Arch Physiol Biochem. 2009 Feb;115(1):22-7.
  • The annotation has been inferred from sequence orthology with LEP (Homo sapiens) [(IEP) inferred from expression pattern]
  • 2 additional annotations were made from Ezenwaka CE, etal., Arch Physiol Biochem. 2009 Feb;115(1):22-7.
  • 797 RGD objects have been annotated to obesity  (DOID:9970)
  • 141 papers in RGD have been used to annotate Lep
  • Curation Notes: protein:increased expression:serum


    • An association has been curated linking Lep and obesity in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Dryden S, etal., Clin Sci (Lond). 1999 Mar;96(3):307-12.
  • The annotation has been inferred from sequence orthology with Lep (Mus musculus) [(IDA) inferred from direct assay]
  • 2 additional annotations were made from Dryden S, etal., Clin Sci (Lond). 1999 Mar;96(3):307-12.
  • 797 RGD objects have been annotated to obesity  (DOID:9970)
  • 141 papers in RGD have been used to annotate Lep
  • Qualifier: treatment
  • Curation Notes: mouse protein in a rat model


    • An association has been curated linking Lep and obesity in Rattus norvegicus.        

  • The association was inferred from direct assay (IDA)
    		•  
  • The annotation was made from Feigh M, etal., Menopause. 2013 Jul;20(7):785-94. doi: 10.1097/GME.0b013e31827c58ab.
  • 2 additional annotations were made from Feigh M, etal., Menopause. 2013 Jul;20(7):785-94. doi: 10.1097/GME.0b013e31827c58ab.
  • 797 RGD objects have been annotated to obesity  (DOID:9970)
  • 141 papers in RGD have been used to annotate Lep
  • Qualifier: treatment


    • An association has been curated linking Lep and obesity in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
  • The annotation has been inferred from sequence orthology with LEP (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 797 RGD objects have been annotated to obesity  (DOID:9970)
  • 141 papers in RGD have been used to annotate Lep
  • Curation Notes: ClinVar Annotator: match by term: Monogenic Non-Syndromic Obesity
  • Original References(s): PMID:25741868 PMID:28492532


    • An association has been curated linking Lep and obesity in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from RGD automated import pipeline for CTD gene-to-disease annotations
  • The annotation has been inferred from sequence orthology with LEP (Homo sapiens) [(EXP) inferred from experiment]
  • 797 RGD objects have been annotated to obesity  (DOID:9970)
  • 141 papers in RGD have been used to annotate Lep
  • Curation Notes: CTD Direct Evidence: marker/mechanism|therapeutic
  • Original References(s): PMID:9202122 PMID:9502777 PMID:9826672 PMID:17517446 PMID:18515891 PMID:19913045 PMID:20122948 PMID:24042701 PMID:25086370 PMID:25551525 PMID:25554529 PMID:26186301 PMID:27071101 PMID:28698385 PMID:31313498


    • An association has been curated linking Lep and obesity in Rattus norvegicus.        

  • The association was inferred from sequence or structural similarity (ISS)
    		•  
  • The annotation was made from RGD automated import pipeline for MGI gene-to-disease annotations
  • The annotation has been inferred from sequence or structural similarity with Lep (Mus musculus) [(IAGP) inferred by association of genotype and phenotype]
  • 797 RGD objects have been annotated to obesity  (DOID:9970)
  • 141 papers in RGD have been used to annotate Lep
  • Curation Notes: OMIM:601665


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