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GENE - TERM ANNOTATION REPORT

6 Annotations Found.

An association has been curated linking TNF and rheumatoid arthritis in Homo sapiens.        

  • The association was inferred by association of genotype and phenotype (IAGP)
    		•  
  • The annotation was made from Swierkot J, etal., Joint Bone Spine. 2015 Mar;82(2):94-9. doi: 10.1016/j.jbspin.2014.08.006. Epub 2014 Oct 11.
  • 8 additional annotations were made from Swierkot J, etal., Joint Bone Spine. 2015 Mar;82(2):94-9. doi: 10.1016/j.jbspin.2014.08.006. Epub 2014 Oct 11.
  • 3384 RGD objects have been annotated to rheumatoid arthritis  (DOID:7148)
  • 539 papers in RGD have been used to annotate TNF
  • Qualifier: treatment
  • Curation Notes: DNA:SNP:promoter:-857C>T (human)


    • An association has been curated linking TNF and rheumatoid arthritis in Homo sapiens.        

  • The association was inferred by association of genotype and phenotype (IAGP)
    		•  
  • The annotation was made from Swierkot J, etal., Joint Bone Spine. 2015 Mar;82(2):94-9. doi: 10.1016/j.jbspin.2014.08.006. Epub 2014 Oct 11.
  • 8 additional annotations were made from Swierkot J, etal., Joint Bone Spine. 2015 Mar;82(2):94-9. doi: 10.1016/j.jbspin.2014.08.006. Epub 2014 Oct 11.
  • 3384 RGD objects have been annotated to rheumatoid arthritis  (DOID:7148)
  • 539 papers in RGD have been used to annotate TNF
  • Qualifier: no_association
  • Curation Notes: DNA:SNP:promoter:-238G>A, -308G>A (human)


    • An association has been curated linking TNF and rheumatoid arthritis in Homo sapiens.        

  • The association was inferred from mutant phenotype (IMP)
    		•  
  • The annotation was made from den Broeder AA, etal., J Rheumatol. 2003 Feb;30(2):232-7.
  • 2 additional annotations were made from den Broeder AA, etal., J Rheumatol. 2003 Feb;30(2):232-7.
  • 3384 RGD objects have been annotated to rheumatoid arthritis  (DOID:7148)
  • 539 papers in RGD have been used to annotate TNF
  • Qualifier: treatment


    • An association has been curated linking TNF and rheumatoid arthritis in Homo sapiens.        

  • The association was inferred from experiment (EXP)
    		•  
  • The annotation was made from RGD automated import pipeline for CTD gene-to-disease annotations
  • 3384 RGD objects have been annotated to rheumatoid arthritis  (DOID:7148)
  • 539 papers in RGD have been used to annotate TNF
  • Curation Notes: CTD Direct Evidence: marker/mechanism|therapeutic
  • Original References(s): PMID:2001072 PMID:8391952 PMID:12566094 PMID:22450443 PMID:34459104


    • An association has been curated linking TNF and rheumatoid arthritis in Homo sapiens.        

  • The association was inferred from expression pattern (IEP)
    		•  
  • The annotation was made from Zhu S, etal., Nat Med. 2012 Jul;18(7):1077-86. doi: 10.1038/nm.2815.
  • 68 additional annotations were made from Zhu S, etal., Nat Med. 2012 Jul;18(7):1077-86. doi: 10.1038/nm.2815.
  • 3384 RGD objects have been annotated to rheumatoid arthritis  (DOID:7148)
  • 539 papers in RGD have been used to annotate TNF
  • Curation Notes: mRNA:increased expression:synovial (human)


    • An association has been curated linking TNF and rheumatoid arthritis in Homo sapiens.        

  • The association was inferred from sequence or structural similarity (ISS)
    		•  
  • The annotation was made from RGD automated import pipeline for MGI gene-to-disease annotations
  • The annotation has been inferred from sequence or structural similarity with Tnf (Mus musculus) [(IAGP) inferred by association of genotype and phenotype]
  • 3384 RGD objects have been annotated to rheumatoid arthritis  (DOID:7148)
  • 539 papers in RGD have been used to annotate TNF
  • Curation Notes: OMIM:180300


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