Phenominer Database Results (75 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Record ID Study ID
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion number to liver volume ratio orchiectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then 17 beta-estradiol (3.3 mg/kg) (for 21 days) then 17 beta-estradiol (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 16820.0 /cm3 5100.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal Add 67445 655
F344.BN-(D16Mit5-D16Rat75) serum testosterone level N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. blood testosterone amount female 0 days 5 0.44 ng/ml 0.03 0.07 immunoassay 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days 67447 655
F344.BN-(D16Mit5-D16Rat75) serum estradiol level ovariectomy then testosterone (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) and testosterone (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. blood estradiol amount female 0 days 5 5.0 pg/ml 0.36 0.81 immunoassay 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67456 655
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion number to liver volume ratio N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 3840.0 /cm3 1450.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days Add "liver tumorous lesion number to liver volume ratio" (new term) as child of "calculated liver tumorous lesion number" (new term). 67437 655
F344.BN-(D16Mit5-D16Rat75) serum estradiol level N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. blood estradiol amount male 0 days 5 12.4 pg/ml 1.12 2.51 immunoassay 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days 67436 655
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 59.0 % 9.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days 67438 655
F344.BN-(D16Mit5-D16Rat75) ratio of proliferating cell nuclear antigen-positive cells to total liver tumorous lesion cells ovariectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 10.67 % 1.4 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal pcna index 68109 655
BN liver tumorous lesion number N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait female 0 days 3 1717.0 null 227.0 393.18 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 68618 950
COP liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy (for 202.5 days) De Miglio MR, et al., Int J Cancer 2004 Aug 10;111(1):9-16. liver integrity trait male 0 days 10 83.0 % ex vivo light microscopy with digital image analysis liver 0.0 224 days 70203 1302
BN ratio of apoptotic bodies to intact tumor cells in nonremodelling liver tumorous lesions N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and controlled 2-acetamidofluorene content diet (0.02 %) then partial hepatectomy De Miglio MR, et al., Int J Cancer 2003 May 20;105(1):70-5. liver integrity trait not specified 0 days 0 1.55 % 0.09 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 0 84780 1603
F344/NRrrc ratio of apoptotic bodies to intact tumor cells in remodelling liver tumorous lesions N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and controlled 2-acetamidofluorene content diet (0.02 %) then partial hepatectomy De Miglio MR, et al., Int J Cancer 2003 May 20;105(1):70-5. liver integrity trait not specified 0 days 5 1.51 % 0.07 0.16 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 0 84787 1603
F344/NHsd percentage of study population developing hepatocellular carcinoma during a period of time N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 490 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 9 89.0 % necropsy 0.0 N-nitrosodiethylamine 490 days CMO:0001068 96757 912
F344.BN-(D16Mit5-D16Rat75) serum testosterone level orchiectomy then 17 beta-estradiol (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then 17 beta-estradiol (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. blood testosterone amount male 0 days 5 0.85 ng/ml 0.03 0.07 immunoassay 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67443 655
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions as percentage of total liver volume orchiectomy then 17 beta-estradiol (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then 17 beta-estradiol (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 19.0 % 5.4 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67446 655
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion number to liver volume ratio ovariectomy then testosterone (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then testosterone (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 7380.0 /cm3 920.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal Add 67457 655
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion number N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 38.6 null 12.06 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 224 days intraperitoneal per liver 67459 655
F344/NRrrc volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait female 0 days 3 8.92 % 2.85 4.94 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 68619 950
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 3 19.2 % 2.8 4.85 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 69148 950
F344.BN-(D16Mit5-D16Rat75) ratio of proliferating cell nuclear antigen-positive cells to total liver tumorous lesion cells orchiectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 6.42 % 0.99 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal pcna index 68106 655
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions as percentage of total liver volume orchiectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 33.0 % 8.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67442 655
F344.BN-(D16Mit5-D16Rat75) serum testosterone level ovariectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. blood testosterone amount female 0 days 5 0.4 ng/ml 0.01 0.02 immunoassay 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67451 655
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 5 30.4 % 2.7 6.04 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 105 days remodeling/total ratio 69146 950
BN/SsNHsd liver tumorous lesion number N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 7 155800.0 null 19408.0 51348.74 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days CMO:0001068 68350 912
F344.BN-(D16Mit5-D16Rat75) ratio of proliferating cell nuclear antigen-positive cells to total liver tumorous lesion cells orchiectomy then 17 beta-estradiol (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then 17 beta-estradiol (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 3.55 % 0.98 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal pcna index 68107 655
F344/NHsd volume of individual liver tumorous lesion N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 12 2.95 cm3 x 10000 0.35 312.98 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days 68351 912
F344/NRrrc liver tumorous lesion number N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait female 0 days 3 1424.0 null 242.0 419.16 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 68617 950
F344/Crli liver tumorous lesion number to liver volume ratio N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified 0 days 20 7875.0 /cm3 624.0 2790.61 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight need to update double congenicstrain 67713 789
BN/Crli volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified 0 days 20 13.69 % 1.99 8.9 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight 67758 789
BN/SsNHsd percentage of study population developing hepatocellular carcinoma during a period of time N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 490 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 10 10.0 % necropsy 0.0 N-nitrosodiethylamine 490 days CMO:0001068 96758 912
F344.BN-(D16Mit5-D16Rat75) serum estradiol level N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. blood estradiol amount female 0 days 5 25.2 pg/ml 1.88 4.21 immunoassay 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days 67448 655
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 10.0 % 4.1 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days 67450 655
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions ovariectomy then testosterone (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then testosterone (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 3.9 cm3 x 10000 0.74 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67796 655
F344.BN-(D16Mit5-D16Rat75) serum estradiol level orchiectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. blood estradiol amount male 0 days 5 8.4 pg/ml 0.9 2.01 immunoassay 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67440 655
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion number to liver volume ratio orchiectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 9420.0 /cm3 990.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal Add "liver tumorous lesion number to liver volume ratio" (new term) as child of "calculated liver tumorous lesion number" (new term). 67441 655
F344.BN-(D16Mit5-D16Rat75) serum estradiol level orchiectomy then 17 beta-estradiol (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) and 17 beta-estradiol (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. blood estradiol amount male 0 days 5 25.7 pg/ml 2.33 5.2 immunoassay 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67444 655
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion diameter measurement N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 4.19 mm 1.3 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 224 days intraperitoneal 67460 655
BN liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy then 5-bromo-2'-deoxyuridine (50 mg/kg) (for 2 hours) Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 5 180.0 % 4.0 8.94 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 69144 950
F344/NRrrc benign liver tumor number N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 16 22.3 null 2.0 8.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 490 days 69151 950
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions orchiectomy then 17 beta-estradiol (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then 17 beta-estradiol (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 0.18 cm3 x 10000 0.11 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67793 655
F344/Crli volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified 0 days 20 80.11 % 6.33 28.32 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight 67755 789
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 4.76 cm3 x 10000 0.4 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days 67791 655
BN ratio of apoptotic bodies to intact tumor cells in remodelling liver tumorous lesions N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and controlled 2-acetamidofluorene content diet (0.02 %) then partial hepatectomy De Miglio MR, et al., Int J Cancer 2003 May 20;105(1):70-5. liver integrity trait not specified 0 days 0 2.08 % 0.18 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 0 84783 1603
F344/Crli volume of individual liver tumorous lesion N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified 0 days 20 3.26 cm3 x 10000 0.33 1.48 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight 67731 789
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions orchiectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 0.47 cm3 x 10000 0.13 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67792 655
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 0.16 cm3 x 10000 0.09 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days 67794 655
F344/NRrrc percentage of study population developing benign liver tumors during a period of time N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 16 100.0 % 5.4 21.6 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 490 days benign liver tumor incidence 69150 950
BN/SsNHsd volume of individual liver tumorous lesion N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 7 0.12 cm3 x 10000 0.03 0.07 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days 68352 912
BN/SsNHsd volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 7 19.83 % 2.09 5.53 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days 68354 912
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion number to liver volume ratio N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 11630.0 /cm3 890.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days Add "liver tumorous lesion number to liver volume ratio" (new term) as child of "calculated liver tumorous lesion number" (new term). 67449 655
F344.BN-(D16Mit5-D16Rat75) serum testosterone level ovariectomy then testosterone (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then testosterone (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. blood testosterone amount female 0 days 5 0.42 ng/ml 0.01 0.02 immunoassay 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67455 655
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 5 15.1 % 1.1 2.46 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 224 days remodeling/total ratio 69147 950
F344/NRrrc malignant liver tumor number N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 16 2.2 null 0.2 0.8 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 490 days check malignant 69153 950
F344/NHsd volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 12 84.18 % 3.64 12.61 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days 68353 912
F344/NHsd hepatocellular carcinoma tumor number N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 mg/kg) (for 490 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 9 3.5 null 0.23 0.69 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 490 days 68391 912
BN/Crli volume of individual liver tumorous lesion N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified 0 days 20 0.09 cm3 x 10000 0.02 0.09 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight 67736 789
F344/NRrrc ratio of apoptotic bodies to intact tumor cells in nonremodelling liver tumorous lesions N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and controlled 2-acetamidofluorene content diet (0.02 %) then partial hepatectomy De Miglio MR, et al., Int J Cancer 2003 May 20;105(1):70-5. liver integrity trait not specified 0 days 5 1.25 % 0.05 0.11 ex vivo light microscopy with immunohistochemistry and digital image analysis 0.0 0 84785 1603
BN/SsNHsd hepatocellular carcinoma tumor number N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 mg/kg) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 10 1.3 null 0.13 0.41 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 490 days 68389 912
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 9 13.8 % 0.8 2.4 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days remodeling/total ratio 69145 950
F344/NHsd liver tumorous lesion number N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 210 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7. liver integrity trait not specified 0 days 12 126820.0 null 9698.0 33594.86 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine 224 days CMO:0001068 68349 912
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion number to liver volume ratio ovariectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 12820.0 /cm3 2800.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal Add "liver tumorous lesion number to liver volume ratio" (new term) as child of "calculated liver tumorous lesion number" (new term). 67453 655
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions as percentage of total liver volume ovariectomy then testosterone (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then testosterone (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 69.0 % 9.8 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67458 655
F344.BN-(D16Mit5-D16Rat75) serum testosterone level orchiectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. blood testosterone amount male 0 days 5 0.95 ng/ml 0.09 0.21 immunoassay 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67439 655
F344.BN-(D16Mit5-D16Rat75) serum testosterone level N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. blood testosterone amount male 0 days 5 2.0 ng/ml 0.22 0.5 immunoassay 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days 67435 655
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 3 40.6 % 5.4 9.35 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 224 days remodeling/total ratio 69149 950
F344.BN-(D16Mit5-D16Rat75) ratio of proliferating cell nuclear antigen-positive cells to total liver tumorous lesion cells N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 12.14 % 1.45 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days pcna index 68105 655
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions ovariectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 0.39 cm3 x 10000 0.15 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67795 655
BN volume of liver occupied by tumorous lesions as percentage of total liver volume N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait female 0 days 3 1.61 % 0.46 0.8 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 68620 950
BN/Crli liver tumorous lesion number to liver volume ratio N-nitrosodiethylamine (150 mg/kg) then 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy De Miglio MR, et al., Cancer Res 2002 Aug 1;62(15):4459-63. liver integrity trait not specified 0 days 20 11142.0 /cm3 930.0 4159.09 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection 224 days 150mg/Kg body weight update term and unit 67721 789
F344.BN-(D16Mit5-D16Rat75) serum estradiol level ovariectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. blood estradiol amount female 0 days 5 13.5 pg/ml 1.65 3.7 immunoassay 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67452 655
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions as percentage of total liver volume ovariectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 19.0 % 4.2 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67454 655
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled protein content diet (for 15 days) and 2-acetamidofluorene (0.02 %) (for 15 days) then partial hepatectomy (for 202.5 days) De Miglio MR, et al., Int J Cancer 2004 Aug 10;111(1):9-16. liver integrity trait male 0 days 10 19.0 % ex vivo light microscopy with digital image analysis liver 0.0 224 days 70204 1302
F344/NRrrc liver remodeling tumorous lesion number to liver total tumorous lesion number ratio N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy then 5-bromo-2'-deoxyuridine (50 mg/kg) (for 2 hours) Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 5 1070.0 % 143.0 319.76 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 56 days 69143 950
F344/NRrrc percentage of study population developing malignant liver tumors during a period of time N-nitrosodiethylamine (150 mg/kg) then controlled 2-acetamidofluorene content diet (0.02 %) (for 14 days) then partial hepatectomy Pascale RM, et al., Carcinogenesis. 1996 Aug;17(8):1765-8. liver integrity trait male 0 days 16 100.0 % 5.4 21.6 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethtlamine injection 490 days check malignant 69152 950
F344.BN-(D16Mit5-D16Rat75) ratio of proliferating cell nuclear antigen-positive cells to total liver tumorous lesion cells N-nitrosodiethylamine (200 mg/kg) (for 56 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 2.76 % 1.1 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days pcna index 68108 655
F344.BN-(D16Mit5-D16Rat75) ratio of proliferating cell nuclear antigen-positive cells to total liver tumorous lesion cells ovariectomy then testosterone (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then testosterone (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait female 0 days 0 15.33 % 0.74 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal pcna index 68110 655