Phenominer Database Results (318 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Record ID Study ID
SHRSP/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 171.2 mmHg 5.3 9.18 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65658 613
SHRSP/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 188.1 mmHg 5.9 10.22 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65659 613
SHRSP/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 151.6 mmHg 3.9 6.75 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65661 613
WKY/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 4 continuous mean 136.6 mmHg 8.2 16.4 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65662 613
WKY/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 131.7 mmHg 3.2 5.54 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65664 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 115.4 mmHg 4.4 7.62 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65681 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 123.9 mmHg 3.6 6.24 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65684 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 120.0 mmHg 6.6 11.43 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65709 613
WKY.SHRSP-(Fst-Pklr)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 120.6 mmHg 8.5 14.72 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65712 613
SHR.BN-(D2Rat226-D2Rat294)/Jk systolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 22 continuous mean 177.6 mmHg 2.0 9.38 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 12751 306
SHRSP/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) Graham D, et al., Hypertension. 2007 Dec; 50(6):1134-41. arterial blood pressure trait male 126 days-147 days 13 225.2 mmHg 5.27 19.0 vascular fluid filled catheter abdominal aorta 1814400 0 implanted at 84 days with 7 day recovery; Dataquest IV telemetry system (Data Sciences International) averaged over 21 days 12729 302
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) Graham D, et al., Hypertension. 2007 Dec; 50(6):1134-41. arterial blood pressure trait male 126 days-147 days 8 189.6 mmHg 3.43 9.7 vascular fluid filled catheter abdominal aorta 1814400 0 implanted at 84 days with 7 day recovery; Dataquest IV telemetry system (Data Sciences International) averaged over 21 days 12731 302
SHRSP.WKY-(D2Mit21-D2Rat157)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) Graham D, et al., Hypertension. 2007 Dec; 50(6):1134-41. arterial blood pressure trait male 126 days-147 days 7 195.9 mmHg 1.53 4.05 vascular fluid filled catheter abdominal aorta 1814400 0 implanted at 84 days with 7 day recovery; Dataquest IV telemetry system (Data Sciences International) averaged over 21 days 12733 302
SBH/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait female 0 days 14 serial mean 194.0 mmHg 1.0 3.74 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12237 236
SBH.SBN-(D1Mgh2-D1Rat101)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait male 0 days 7 serial mean 181.0 mmHg 7.0 18.52 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12244 236
SBH.SBN-(D1Wox11-D1Rat137)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait male 0 days 9 serial mean 172.0 mmHg 7.0 21.0 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12248 236
SBH.SBN-(D1Wox11-D1Rat137)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait female 0 days 6 serial mean 162.0 mmHg 6.0 14.7 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12249 236
SBH.SBN-(D1Rat137-D1Rat123)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait female 0 days 9 serial mean 162.0 mmHg 6.0 18.0 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12265 236
BN systolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 64 continuous mean 134.4 mmHg 8.7 69.6 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65342 306
SHR.BN-(D2Rat114-D2Rat123)/Jk diastolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 133.0 mmHg 2.0 9.59 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65343 306
SHRSP/Gcrc pulse pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 137 days-140 days 6 continuous mean 63.8 mmHg 1.63 4.0 intra-aortic abdominal radiotelemetry abdominal aorta 0 11638 109
WKY/Gcrc pulse pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 137 days-140 days 6 continuous mean 45.9 mmHg 1.14 2.8 intra-aortic abdominal radiotelemetry abdominal aorta 0 11640 109
WKY/Bbb diastolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Monti J, et al., Hum Mol Genet 2003 Feb 15;12(4):435-9. arterial blood pressure trait male 110 days-124 days 20 84.45 mmHg 0.68 3.04 intra-aortic abdominal radiotelemetry 0 0 12656 281
WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/Bbb systolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Monti J, et al., Hum Mol Genet 2003 Feb 15;12(4):435-9. arterial blood pressure trait male 110 days-124 days 10 136.96 mmHg 1.91 6.04 intra-aortic abdominal radiotelemetry 0 12661 281
SHR.BN-(D4Rat33-D4Rat54)/Jk mean arterial blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 162.0 mmHg 2.0 9.59 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65409 306
SHR.BN-(D16Rat87-D16Mgh1)/Jk diastolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 130.0 mmHg 3.0 14.39 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65414 306
SHR.BN-(D16Rat87-D16Mgh1)/Jk mean arterial blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 154.0 mmHg 3.0 14.39 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65415 306
WKY.SHRSP-(Mt1pa-D1Rat200)/Bbb diastolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Hubner N, et al., Hypertension 1999 Oct;34(4 Pt 1):643-8 arterial blood pressure trait not specified 124 days 9 97.4 mmHg 1.03 3.1 radiotelemetry 0.0 0 67205 112
WKY/Bbb mean arterial blood pressure controlled sodium content drinking water (1 %) (for 12 days) Hubner N, et al., Hypertension 1999 Oct;34(4 Pt 1):643-8 arterial blood pressure trait not specified 124 days 11 107.9 mmHg 1.24 4.1 radiotelemetry 0.0 0 67208 112
SHR/Bbb percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content diet (3.7 mg/g) (for 140 days) and controlled sodium content drinking water (1 %) (for 140 days) and controlled potassium content diet (6.3 mg/g) (for 140 days) Rubattu S, et al., Nat Genet 1996 Aug;13(4):429-34 cerebrovascular system integrity trait both 182 days 30 20.0 % ex vivo light microscopy 0.0 0 69118 1125
SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content diet (3.7 mg/g) (between 42 and 91 days) and controlled sodium content drinking water (1 %) (between 42 and 91 days) and controlled potassium content diet (6.3 mg/g) (between 42 and 91 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. cerebrovascular system integrity trait not specified 81 days-133 days 31 20.0 % ex vivo light microscopy 0.0 0 69124 1126
SHRSR/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 70 days 18 185.0 mmHg 1.72 7.3 tail cuff plethysmography 0.0 0 69127 1126
SHRSR/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 70 days) and controlled sodium content drinking water (1 %) (for 70 days) and controlled potassium content diet (6.3 mg/g) (for 70 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 112 days 18 199.0 mmHg 0.24 1.0 tail cuff plethysmography 0.0 0 69130 1126
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 70 days 33 174.0 mmHg 3.31 19.0 tail cuff plethysmography 0.0 0 69167 1126
SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 70 days 31 176.0 mmHg 1.89 10.5 tail cuff plethysmography 0.0 0 69174 1126
SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 70 days) and controlled sodium content drinking water (1 %) (for 70 days) and controlled potassium content diet (6.3 mg/g) (for 70 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 112 days 31 206.0 mmHg 1.44 8.0 tail cuff plethysmography 0.0 0 69177 1126
SHRSP.SHRSR-(Klk1-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 56 days 33 164.0 mmHg 2.61 15.0 tail cuff plethysmography 0.0 0 69187 1126
SHRSP.SHRSR-(Klk1-D1Mit3)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 56 days 31 153.0 mmHg 2.16 12.0 tail cuff plethysmography 0.0 0 69192 1126
SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 70 days 31 74.0 mg/d 2.69 15.0 Bradford protein assay 0.0 0 70244 1126
SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 84 days 31 51.0 mg/d 3.95 22.0 Bradford protein assay 0.0 0 70252 1126
SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 84 days) and controlled sodium content drinking water (1 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 126 days 25 111.0 mg/d 17.2 86.0 Bradford protein assay 0.0 0 70255 1126
SHRSP.SHRSR-(Klk1-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 84 days 20 232.0 mg/d 20.35 91.0 Bradford protein assay 0.0 0 70259 1126
SHRSR/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 84 days 18 56.0 mg/d 0.94 4.0 Bradford protein assay 0.0 0 69211 1126
SHRSR/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 84 days) and controlled sodium content drinking water (1 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 126 days 18 89.0 mg/d 2.12 9.0 Bradford protein assay 0.0 0 69214 1126
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 98 days 32 270.0 mg/d 6.01 34.0 Bradford protein assay 0.0 0 69223 1126
LH/Mav heart left ventricle weight to body weight ratio controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. heart left ventricle mass male 119 days 7 2.48 mg/g 0.04 0.11 post excision weight measurement 0.0 0 103409 2824
LH/Mav heart left ventricle weight to body weight ratio perindopril (0.4 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. heart left ventricle mass male 119 days 8 2.41 mg/g 0.08 0.23 post excision weight measurement 0.0 0 103410 2824
LH/Mav aorta weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. aorta mass male 119 days 7 15.8 mg/100g 0.8 2.12 post excision weight measurement 0.0 0 103418 2824
SBH/Ygl body weight deoxycorticosterone acetate (75 mg) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) Rothermund L, et al., Eur J Pharmacol. 2003 May 16;468(3):209-16. doi: 10.1016/s0014-2999(03)01714-x. body mass male 16 days 8 340.0 g 8.9 25.17 body weighing method 0.0 0 n=8-15 106644 3035
SBH/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (between 24 and 28 days) and deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait female 276 days-280 days 5 51.0 mmHg 2.0 4.47 tail cuff plethysmography 0.0 0 n=5-7, change between age 9months and 10 months 106743 3039
SBH/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (for 30 days) and deoxycorticosterone acetate (25 mg) (for 30 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait female 52 days-56 days 5 56.0 mmHg 2.0 4.47 tail cuff plethysmography 0.0 0 n=5-7, change between age 1month and 2 months 106731 3039
SHRSP/A3N kidney glomerular lesion count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney glomerulus integrity trait male 210 days-224 days 0 4.0 /section 2.0 ex vivo light microscopy with histochemistry 0.0 0 107478 3088
SHRSP/A3N kidney tubule regeneration foci count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 6.4 /section 1.0 ex vivo light microscopy with histochemistry 0.0 0 foci of tubular regeneration 107485 3088
SHRSP/A3N interstitial nephritis foci count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 6.6 /section 2.3 ex vivo light microscopy with histochemistry 0.0 0 foci of interstitial nephritis 107489 3088
SHRSP/A3N interstitial nephritis foci count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 2.4 /section 0.8 ex vivo light microscopy with histochemistry 0.0 0 foci of interstitial nephritis 107490 3088
SHRSP/A3N kidney total tubule cast count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 350.0 /section 80.0 ex vivo light microscopy with histochemistry 0.0 0 total tubular casts 107493 3088
SHRSP/A3N body weight controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. body mass male 203 days-224 days 10 367.0 g 10.0 31.62 body weighing method 0.0 0 high salt high fat diet +carvedilol 107103 3075
SBN.SBH-(D1Rat148-D1Rat89)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait male 0 days 12 serial mean 130.0 mmHg 1.0 3.46 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12306 236
SBH/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait male 0 days 13 serial mean 197.0 mmHg 1.0 3.61 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12236 236
SBH.SBN-(D1Mgh2-D1Mgh11)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait female 0 days 16 serial mean 156.0 mmHg 3.0 12.0 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12269 236
SBH.SBN-(D1Mgh2-D1Rat74)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait female 0 days 13 serial mean 154.0 mmHg 5.0 18.03 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12273 236
WKY/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 4 continuous mean 144.2 mmHg 8.8 17.6 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65663 613
WKY/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 4 continuous mean 117.7 mmHg 7.5 15.0 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65671 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 156.8 mmHg 11.8 20.44 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65691 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 140.7 mmHg 8.0 13.86 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65700 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 126.6 mmHg 4.8 8.31 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65706 613
WKY.SHRSP-(Fst-Pklr)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 156.0 mmHg 2.5 4.33 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65711 613
SHRSP.WKY-(Klk1-D1Rat116)/Izm percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content drinking water (1 %) (for 14 days) Kato N, et al., Hypertension 2003 DXCO;42(6):1191-7. cerebrovascular system integrity trait male 98 days 13 0.0 % ex vivo light microscopy MA:0000168 0 0 65297 115
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 84 days 33 75.0 mg/d 3.31 19.0 Bradford protein assay 0.0 0 69222 1126
SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 56 days 31 22.0 mg/d 1.9 10.6 Bradford protein assay 0.0 0 70243 1126
SHRSP/Bbb percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content diet (3.7 mg/g) (between 70 and 88 days) and controlled sodium content drinking water (1 %) (between 70 and 88 days) and controlled potassium content diet (6.3 mg/g) (between 70 and 88 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. cerebrovascular system integrity trait not specified 70 days-88 days 31 100.0 % ex vivo light microscopy 0.0 0 69119 1126
WKY/Bbb diastolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Hubner N, et al., Hypertension 1999 Oct;34(4 Pt 1):643-8 arterial blood pressure trait not specified 124 days 11 89.8 mmHg 1.03 3.4 radiotelemetry 0.0 0 67204 112
SHRSP/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 173.4 mmHg 3.9 6.75 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65652 613
SHRSP/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 185.5 mmHg 4.5 7.79 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65653 613
WKY/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 4 continuous mean 104.4 mmHg 6.9 13.8 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65667 613
WKY/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 105.2 mmHg 2.9 5.02 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65672 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 139.0 mmHg 8.1 14.03 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65679 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 144.2 mmHg 12.1 20.96 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65690 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 133.1 mmHg 4.8 8.31 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65707 613
WKY.SHRSP-(Fst-Pklr)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 130.6 mmHg 8.2 14.2 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65713 613
WKY/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 137 days-140 days 6 continuous mean 101.2 mmHg 3.02 7.4 intra-aortic abdominal radiotelemetry abdominal aorta 0 11637 109
WKY/Gcrc pulse pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait male 137 days-140 days 6 continuous mean 52.9 mmHg 1.51 3.7 intra-aortic abdominal radiotelemetry abdominal aorta 0 11639 109
WKY.SHRSP-(Mt1pa-D1Rat200)/Bbb systolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Hubner N, et al., Hypertension 1999 Oct;34(4 Pt 1):643-8 arterial blood pressure trait not specified 124 days 9 138.3 mmHg 1.53 4.6 radiotelemetry 0.0 0 11652 112
SHR.BN-(D16Rat87-D16Mgh1)/Jk systolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 178.5 mmHg 2.7 12.95 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 12753 306
SBN/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait male 0 days 13 serial mean 128.0 mmHg 1.0 3.61 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12240 236
WKY/Bbb heart rate controlled sodium content drinking water (1 %) (between 13 and 15 days) Kreutz R, et al., Circulation 1997 Aug 19;96(4):1078-81. heart pumping trait male 125 days-127 days 11 serial mean 349.0 beats/min 12.06 40.0 vascular indwelling catheter method femoral artery 0 3 sets of readings per day for two days 13286 334
SHRSP/Bbb heart rate controlled sodium content drinking water (1 %) (between 13 and 15 days) Kreutz R, et al., Circulation 1997 Aug 19;96(4):1078-81. heart pumping trait male 125 days-127 days 12 serial mean 433.0 beats/min 4.33 15.0 vascular indwelling catheter method femoral artery 0 3 sets of readings per day for two days 13290 334
WKY.SHRSP-(D1Rat200-D1Rat216)/Bbb diastolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Monti J, et al., Hum Mol Genet 2003 Feb 15;12(4):435-9. arterial blood pressure trait male 110 days-124 days 12 92.94 mmHg 1.11 3.85 intra-aortic abdominal radiotelemetry 0 12658 281
SHR.BN-(D2Rat226-D2Rat294)/Jk mean arterial blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 22 continuous mean 154.0 mmHg 2.0 9.38 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65403 306
SHR.BN-(D4Rat33-D4Rat54)/Jk diastolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 136.0 mmHg 2.0 9.59 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65408 306
SHRSP/Izm percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content drinking water (1 %) (for 28 days) Kato N, et al., Hypertension 2003 DXCO;42(6):1191-7. cerebrovascular system integrity trait male 112 days 12 100.0 % ex vivo light microscopy MA:0000168 0 0 65294 115
SHRSP/Izm percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content drinking water (1 %) (for 28 days) Kato N, et al., Hypertension 2003 DXCO;42(6):1191-7. cerebrovascular system integrity trait female 112 days 10 60.0 % ex vivo light microscopy MA:0000168 0 0 65295 115
SHRSP.WKY-(Klk1-D1Rat116)/Izm percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content drinking water (1 %) (for 28 days) Kato N, et al., Hypertension 2003 DXCO;42(6):1191-7. cerebrovascular system integrity trait male 112 days 9 0.0 % ex vivo light microscopy MA:0000168 0 0 65301 115
SHRSR/Bbb percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content diet (3.7 mg/g) (for 84 days) and controlled sodium content drinking water (1 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. cerebrovascular system integrity trait not specified 126 days 18 0.0 % ex vivo light microscopy 0.0 0 69120 1126
SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content diet (3.7 mg/g) (between 28 and 49 days) and controlled sodium content drinking water (1 %) (between 28 and 49 days) and controlled potassium content diet (6.3 mg/g) (between 28 and 49 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. cerebrovascular system integrity trait not specified 70 days-91 days 34 63.0 % ex vivo light microscopy 0.0 0 69122 1126
SHRSR/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 84 days) and controlled sodium content drinking water (1 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 126 days 18 188.0 mmHg 2.83 12.0 tail cuff plethysmography 0.0 0 69131 1126
SHRSR/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 70 days) and controlled sodium content drinking water (1 %) (for 70 days) and controlled potassium content diet (6.3 mg/g) (for 70 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 112 days 18 80.0 mg/d 1.06 4.5 Bradford protein assay 0.0 0 69213 1126
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 98 days 32 199.0 mmHg 1.77 10.0 tail cuff plethysmography 0.0 0 69169 1126
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 84 days) and controlled sodium content drinking water (1 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 126 days 26 197.0 mmHg 4.12 21.0 tail cuff plethysmography 0.0 0 69171 1126
SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 84 days 31 191.0 mmHg 0.72 4.0 tail cuff plethysmography 0.0 0 69182 1126
SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 98 days 30 195.0 mmHg 1.46 8.0 tail cuff plethysmography 0.0 0 69183 1126
SHRSP.SHRSR-(Klk1-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 98 days 3 195.0 mmHg 2.89 5.0 tail cuff plethysmography 0.0 0 69190 1126
SHRSP.SHRSR-(Klk1-D1Mit3)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 84 days 22 200.0 mmHg 0.85 4.0 tail cuff plethysmography 0.0 0 69194 1126
SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 56 days 35 153.0 mmHg 2.03 12.0 tail cuff plethysmography 0.0 0 69196 1126
SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 98 days 14 192.0 mmHg 1.6 6.0 tail cuff plethysmography 0.0 0 69199 1126
SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 84 days) and controlled sodium content drinking water (1 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 126 days 31 58.0 mg/d 1.33 7.4 Bradford protein assay 0.0 0 70248 1126
SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 70 days 31 60.0 mg/d 2.51 14.0 Bradford protein assay 0.0 0 70251 1126
SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 70 days) and controlled sodium content drinking water (1 %) (for 70 days) and controlled potassium content diet (6.3 mg/g) (for 70 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 112 days 28 169.0 mg/d 16.25 86.0 Bradford protein assay 0.0 0 70254 1126
SHRSP.SHRSR-(Klk1-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 56 days 33 38.0 mg/d 1.91 11.0 Bradford protein assay 0.0 0 70257 1126
SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content diet (3.7 mg/g) (between 28 and 91 days) and controlled sodium content drinking water (1 %) (between 28 and 91 days) and controlled potassium content diet (6.3 mg/g) (between 28 and 91 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. cerebrovascular system integrity trait not specified 70 days-133 days 35 100.0 % ex vivo light microscopy 0.0 0 84576 1126
SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 84 days 34 275.0 mg/d 14.41 84.0 Bradford protein assay 0.0 0 84584 1126
SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 84 days) and controlled sodium content drinking water (1 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 126 days 1 400.0 mg/d Bradford protein assay 0.0 0 84587 1126
LH/Mav heart left ventricle weight to body weight ratio perindopril (1.5 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. heart left ventricle mass male 119 days 8 2.37 mg/g 0.07 0.2 post excision weight measurement 0.0 0 103411 2824
LH/Mav aorta weight to body weight ratio perindopril (1.5 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. aorta mass male 119 days 8 13.6 mg/100g 0.5 1.41 post excision weight measurement 0.0 0 103416 2824
LH/Mav aorta weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. aorta mass male 119 days 6 15.7 mg/100g 0.8 1.96 post excision weight measurement 0.0 0 103417 2824
SBN/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (between 24 and 28 days) and deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait male 192 days-196 days 5 1.0 mmHg 1.0 2.24 tail cuff plethysmography 0.0 0 n=5-7, change between age 6 months and 7 months 106736 3039
SBN/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (between 24 and 28 days) and deoxycorticosterone acetate (75 mg) (between 24 and 28 days) then deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait female 360 days-364 days 5 2.0 mmHg 1.0 2.24 tail cuff plethysmography 0.0 0 n=5-7, change between age 12months and 13 months 106745 3039
SHRSP/A3N heart rate controlled sodium content drinking water (1 %) (between 112 and 126 days) and controlled fat content diet (24.5 %) (between 112 and 126 days) Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. heart pumping trait male 189 days-210 days 0 277.0 beats/min 6.0 transthoracic echocardiography 0.0 0 high salt high fat diet 107130 3075
SBN/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (for 30 days) and deoxycorticosterone acetate (25 mg) (for 30 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait male 52 days-56 days 5 2.0 mmHg 1.0 2.24 tail cuff plethysmography 0.0 0 n=5-7, change between age 1month and 2 months 106728 3039
SBN/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (between 24 and 28 days) and deoxycorticosterone acetate (75 mg) (for 90 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait female 108 days-112 days 5 4.0 mmHg 1.0 2.24 tail cuff plethysmography 0.0 0 n=5-7, change between age 3months and 4 months 106733 3039
SBH/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (between 24 and 28 days) and deoxycorticosterone acetate (75 mg) (for 90 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait male 108 days-112 days 5 58.0 mmHg 4.0 8.94 tail cuff plethysmography 0.0 0 n=5-7, change between age 3months and 4 months 106734 3039
SBN/Ygl systolic blood pressure controlled exposure to a foster mother of a different strain within the same species. (for 30 days) then controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait male 70 days 12 128.0 mmHg 1.0 3.46 tail cuff plethysmography 0.0 0 106749 3039
SBN/Ygl both kidneys wet weight to body weight ratio deoxycorticosterone acetate (75 mg) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) Rothermund L, et al., Eur J Pharmacol. 2003 May 16;468(3):209-16. doi: 10.1016/s0014-2999(03)01714-x. kidney mass male 16 days 8 2.6 g/kg 0.05 0.14 post excision weight measurement 0.0 0 n=8-15 106647 3035
SBN/Ygl both kidneys wet weight to body weight ratio deoxycorticosterone acetate (75 mg) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and darusentan (50 mg/kg/d) (for 56 days) Rothermund L, et al., Eur J Pharmacol. 2003 May 16;468(3):209-16. doi: 10.1016/s0014-2999(03)01714-x. kidney mass male 16 days 8 3.2 g/kg 0.06 0.17 post excision weight measurement 0.0 0 n=8-15 106651 3035
SBH/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (for 30 days) and deoxycorticosterone acetate (25 mg) (for 30 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait male 52 days-56 days 5 52.0 mmHg 3.0 6.71 tail cuff plethysmography 0.0 0 n=5-7, change between age 1month and 2 months 106730 3039
SBN/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (between 24 and 28 days) and deoxycorticosterone acetate (75 mg) (between 24 and 28 days) then deoxycorticosterone acetate (75 mg) (for 90 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait female 192 days-196 days 5 5.0 mmHg 2.0 4.47 tail cuff plethysmography 0.0 0 n=5-7, change between age 6 months and 7 months 106737 3039
SBH/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (between 24 and 28 days) and deoxycorticosterone acetate (75 mg) (between 24 and 28 days) then deoxycorticosterone acetate (75 mg) (for 90 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait male 192 days-196 days 5 54.0 mmHg 2.0 4.47 tail cuff plethysmography 0.0 0 n=5-7, change between age 6 months and 7 months 106738 3039
SBH/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (between 24 and 28 days) and deoxycorticosterone acetate (75 mg) (between 24 and 28 days) then deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait female 360 days-364 days 5 53.0 mmHg 1.0 2.24 tail cuff plethysmography 0.0 0 n=5-7, change between age 12months and 13 months 106747 3039
SHRSP/A3NCrl urine albumin excretion rate controlled sodium content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. urine albumin amount male 99 days-148 days 9 142.0 mg/d 42.0 126.0 urine microalbumin analysis 86400.0 0 8 week HSFD plus treatment 8 week high salt high fat plus treatment 107061 3073
SHRSP/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 229.8 mmHg 7.3 12.64 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65651 613
SBN.SBH-(D1Rat148-D1Rat89)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait female 0 days 8 serial mean 128.0 mmHg 1.0 2.83 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12308 236
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 130.8 mmHg 4.8 8.31 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65685 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 163.5 mmHg 12.2 21.13 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65694 613
SHRSR/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 98 days 18 83.0 mg/d 1.04 4.4 Bradford protein assay 0.0 0 69212 1126
SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 70 days) and controlled sodium content drinking water (1 %) (for 70 days) and controlled potassium content diet (6.3 mg/g) (for 70 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 112 days 31 89.0 mg/d 12.75 71.0 Bradford protein assay 0.0 0 70247 1126
SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 98 days 30 54.0 mg/d 4.93 27.0 Bradford protein assay 0.0 0 70253 1126
WKY.SHRSP-(Mt1pa-D1Rat57)/Bbb mean arterial blood pressure controlled sodium content drinking water (1 %) (for 12 days) Hubner N, et al., Hypertension 1999 Oct;34(4 Pt 1):643-8 arterial blood pressure trait not specified 124 days 11 110.9 mmHg 1.45 4.8 radiotelemetry 0.0 0 67211 112
LH/Mav heart left ventricle weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. heart left ventricle mass male 119 days 7 2.79 mg/g 0.04 0.11 post excision weight measurement 0.0 0 103413 2824
LH/Mav both kidneys wet weight to body weight ratio perindopril (0.4 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. kidney mass male 119 days 8 6.22 g/kg 0.21 0.59 post excision weight measurement 0.0 0 103420 2824
WKY/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait male 137 days-140 days 6 continuous mean 115.8 mmHg 1.8 4.4 intra-aortic abdominal radiotelemetry abdominal aorta 0 11636 109
SHRSP/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 121.7 mmHg 3.1 5.37 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65656 613
WKY/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 4 continuous mean 110.0 mmHg 7.0 14.0 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65670 613
WKY/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 112.2 mmHg 2.7 4.68 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65673 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 221.3 mmHg 15.4 26.67 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65687 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 134.1 mmHg 4.2 7.27 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65696 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 155.8 mmHg 3.7 6.41 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65698 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 163.0 mmHg 3.8 6.58 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65699 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 149.3 mmHg 7.0 12.12 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65701 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 112.0 mmHg 5.6 9.7 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65702 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 97.8 mmHg 6.8 11.78 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65704 613
WKY.SHRSP-(Fst-Pklr)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 108.4 mmHg 1.4 2.42 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65715 613
WKY.SHRSP-(Fst-Pklr)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 115.0 mmHg 1.5 2.6 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65718 613
WKY.SHRSP-(Fst-Pklr)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 104.8 mmHg 7.5 12.99 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65721 613
SBN.SBH-(D1Mgh17-D1Mgh14)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait female 0 days 8 serial mean 128.0 mmHg 1.0 2.83 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12301 236
SHRSP.WKY-(D2Wox9-D2Mgh12)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) Graham D, et al., Hypertension. 2007 Dec; 50(6):1134-41. arterial blood pressure trait male 126 days-147 days 12 218.2 mmHg 7.28 25.22 vascular fluid filled catheter abdominal aorta 1814400 0 implanted at 84 days with 7 day recovery; Dataquest IV telemetry system (Data Sciences International) averaged over 21 days 12735 302
WKY/Bbb systolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Monti J, et al., Hum Mol Genet 2003 Feb 15;12(4):435-9. arterial blood pressure trait male 110 days-124 days 20 126.13 mmHg 0.55 2.46 intra-aortic abdominal radiotelemetry 0 0 12654 281
SBH.SBN-(D1Rat137-D1Rat83)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait female 0 days 7 serial mean 173.0 mmHg 3.0 7.94 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12256 236
SBH.SBN-(D1Mgh2-D1Mgh11)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait male 0 days 13 serial mean 163.0 mmHg 5.0 18.03 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12268 236
SBN.SBH-(D1Rat27-D1Mit7)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait male 0 days 10 serial mean 132.0 mmHg 2.0 6.32 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12280 236
SBN.SBH-(D1Rat101-D1Rat74)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait female 0 days 8 serial mean 128.0 mmHg 1.0 2.83 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12294 236
SHRSP/Bbb heart rate controlled sodium content drinking water (1 %) (between 13 and 15 days) Kreutz R, et al., Circulation 1997 Aug 19;96(4):1078-81. heart pumping trait female 125 days-127 days 10 serial mean 442.0 beats/min 9.17 29.0 vascular indwelling catheter method femoral artery 0 3 sets of readings per day for two days 13291 334
WKY.SHRSP-(Shbg-Atp1b2)/Bbb systolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Monti J, et al., Hum Mol Genet 2003 Feb 15;12(4):435-9. arterial blood pressure trait male 110 days-124 days 33 129.42 mmHg 0.85 4.88 intra-aortic abdominal radiotelemetry 0 12659 281
SHR.BN-(D2Rat226-D2Rat294)/Jk diastolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 22 continuous mean 131.0 mmHg 2.0 9.38 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65402 306
SHRSP/Izm percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content drinking water (1 %) (for 14 days) Kato N, et al., Hypertension 2003 DXCO;42(6):1191-7. cerebrovascular system integrity trait male 98 days 12 50.0 % ex vivo light microscopy MA:0000168 0 0 65291 115
SHRSP.WKY-(Klk1-D1Rat116)/Izm percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content drinking water (1 %) (for 14 days) Kato N, et al., Hypertension 2003 DXCO;42(6):1191-7. cerebrovascular system integrity trait female 98 days 9 0.0 % ex vivo light microscopy MA:0000168 0 0 65299 115
WKY.SHRSP-(Mt1pa-D1Rat57)/Bbb systolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Hubner N, et al., Hypertension 1999 Oct;34(4 Pt 1):643-8 arterial blood pressure trait not specified 124 days 11 135.2 mmHg 1.45 4.8 radiotelemetry 0.0 0 67203 112
WKY.SHRSP-(Mt1pa-D1Rat200)/Bbb mean arterial blood pressure controlled sodium content drinking water (1 %) (for 12 days) Hubner N, et al., Hypertension 1999 Oct;34(4 Pt 1):643-8 arterial blood pressure trait not specified 124 days 9 115.9 mmHg 1.2 3.6 radiotelemetry 0.0 0 67210 112
SHRSR/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 84 days 18 191.0 mmHg 3.02 12.8 tail cuff plethysmography 0.0 0 69128 1126
SHRSR/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 70 days 18 60.0 mg/d 4.24 18.0 Bradford protein assay 0.0 0 69210 1126
SHRSP/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 56 days 31 35.0 mg/d 0.61 3.4 Bradford protein assay 0.0 0 69216 1126
SHRSP/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 70 days 26 215.0 mg/d 18.43 94.0 Bradford protein assay 0.0 0 69217 1126
SHRSP/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 84 days 5 194.0 mg/d 42.49 95.0 Bradford protein assay 0.0 0 69218 1126
SHRSP/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 70 days 26 187.0 mmHg 2.55 13.0 tail cuff plethysmography 0.0 0 69163 1126
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 56 days 33 148.0 mmHg 3.13 18.0 tail cuff plethysmography 0.0 0 69166 1126
SHRSP.SHRSR-(Klk1-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 70 days 33 186.0 mmHg 1.2 6.9 tail cuff plethysmography 0.0 0 69188 1126
SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 70 days 35 188.0 mmHg 2.11 12.5 tail cuff plethysmography 0.0 0 69197 1126
SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 84 days) and controlled sodium content drinking water (1 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 126 days 1 193.0 mmHg tail cuff plethysmography 0.0 0 69201 1126
SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 98 days 31 81.0 mg/d 4.13 23.0 Bradford protein assay 0.0 0 70246 1126
SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 56 days 35 24.0 mg/d 1.86 11.0 Bradford protein assay 0.0 0 84582 1126
LH/Mav both kidneys wet weight to body weight ratio perindopril (1.5 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. kidney mass male 119 days 8 5.87 g/kg 0.1 0.28 post excision weight measurement 0.0 0 103421 2824
LH/Mav both kidneys wet weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. kidney mass male 119 days 7 7.3 g/kg 0.09 0.24 post excision weight measurement 0.0 0 103423 2824
SBN/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (between 24 and 28 days) and deoxycorticosterone acetate (75 mg) (for 90 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait male 108 days-112 days 5 2.0 mmHg 1.0 2.24 tail cuff plethysmography 0.0 0 n=5-7, change between age 3months and 4 months 106732 3039
SBN/Ygl systolic blood pressure controlled exposure to a foster mother of a different strain within the same species. (for 30 days) then controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait female 70 days 16 126.0 mmHg 1.0 4.0 tail cuff plethysmography 0.0 0 106751 3039
SBN/Ygl body weight deoxycorticosterone acetate (75 mg) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) Rothermund L, et al., Eur J Pharmacol. 2003 May 16;468(3):209-16. doi: 10.1016/s0014-2999(03)01714-x. body mass male 16 days 8 319.0 g 5.0 14.14 body weighing method 0.0 0 n=8-15 106641 3035
SBH/Ygl both kidneys wet weight to body weight ratio deoxycorticosterone acetate (75 mg) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) Rothermund L, et al., Eur J Pharmacol. 2003 May 16;468(3):209-16. doi: 10.1016/s0014-2999(03)01714-x. kidney mass male 16 days 8 3.0 g/kg 0.08 0.23 post excision weight measurement 0.0 0 n=8-15 106650 3035
SHRSP/A3NCrl urine albumin excretion rate controlled sodium content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. urine albumin amount male 99 days-148 days 9 282.4 mg/d 20.2 60.6 urine microalbumin analysis 86400.0 0 8 week HSFD 8 week high salt high fat diet group 107060 3073
SHRSP/A3N kidney total tubule cast count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 21.0 /section 11.0 ex vivo light microscopy with histochemistry 0.0 0 total tubular casts 107494 3088
SHRSP/A3N renal fibrosis foci count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 25.0 /section 1.0 ex vivo light microscopy with histochemistry 0.0 0 foci of renal fibrosis 107497 3088
SHRSP/A3N renal fibrosis foci count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 15.0 /section 2.0 ex vivo light microscopy with histochemistry 0.0 0 foci of renal fibrosis 107498 3088
SHRSP/A3N end-systolic volume controlled sodium content drinking water (1 %) (between 112 and 126 days) and controlled fat content diet (24.5 %) (between 112 and 126 days) Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. cardiac output trait male 189 days-210 days 0 0.29 ml 0.04 transthoracic echocardiography 0.0 0 high salt high fat diet 107126 3075
SBN/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait female 0 days 14 serial mean 126.0 mmHg 1.0 3.74 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12241 236
SBH.SBN-(D1Rat137-D1Rat123)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait male 0 days 9 serial mean 169.0 mmHg 8.0 24.0 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12264 236
SBN.SBH-(D1Rat101-D1Rat74)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait male 0 days 7 serial mean 131.0 mmHg 1.0 2.65 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12293 236
SBN.SBH-(D1Mgh17-D1Mgh14)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait male 0 days 11 serial mean 130.0 mmHg 1.0 3.32 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12300 236
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 108.5 mmHg 3.6 6.24 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65680 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 167.6 mmHg 5.5 9.53 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65688 613
WKY.SHRSP-(Fst-Pklr)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 99.5 mmHg 1.2 2.08 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65714 613
WKY.SHRSP-(Fst-Pklr)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 91.9 mmHg 7.4 12.82 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65717 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 161.6 mmHg 5.4 9.35 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65677 613
SHRSP.SHRSR-(Klk1-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 98 days 3 351.0 mg/d 28.87 50.0 Bradford protein assay 0.0 0 70260 1126
SHRSP/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 84 days 5 201.0 mmHg 8.72 19.5 tail cuff plethysmography 0.0 0 69164 1126
SHRSR/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 98 days 18 191.0 mmHg 1.65 7.0 tail cuff plethysmography 0.0 0 69129 1126
WKY.SHRSP-(Mt1pa-D1Rat57)/Bbb diastolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Hubner N, et al., Hypertension 1999 Oct;34(4 Pt 1):643-8 arterial blood pressure trait not specified 124 days 11 91.7 mmHg 1.42 4.7 radiotelemetry 0.0 0 67207 112
SHR.BN-(D2Rat114-D2Rat123)/Jk mean arterial blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 156.0 mmHg 3.0 14.39 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65344 306
SHRSP/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 137 days-140 days 6 continuous mean 214.3 mmHg 5.88 14.4 intra-aortic abdominal radiotelemetry abdominal aorta 0 11632 109
SHRSP/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 137 days-140 days 6 continuous mean 150.5 mmHg 4.45 10.9 intra-aortic abdominal radiotelemetry abdominal aorta 0 11635 109
WKY.SHRSP-(Shbg-Atp1b2)/Bbb diastolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Monti J, et al., Hum Mol Genet 2003 Feb 15;12(4):435-9. arterial blood pressure trait male 110 days-124 days 33 91.08 mmHg 0.87 5.0 intra-aortic abdominal radiotelemetry 0 12660 281
WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/Bbb diastolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Monti J, et al., Hum Mol Genet 2003 Feb 15;12(4):435-9. arterial blood pressure trait male 110 days-124 days 10 96.86 mmHg 1.09 3.45 intra-aortic abdominal radiotelemetry 0 12662 281
SHRSP/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 207.9 mmHg 5.5 9.53 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65650 613
WKY/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 98.8 mmHg 2.8 4.85 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65669 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 147.8 mmHg 4.3 7.45 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65682 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 127.9 mmHg 4.0 6.93 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65693 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 105.4 mmHg 6.3 10.91 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65705 613
WKY.SHRSP-(Fst-Pklr)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 146.1 mmHg 2.2 3.81 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65710 613
WKY/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) Graham D, et al., Hypertension. 2007 Dec; 50(6):1134-41. arterial blood pressure trait male 126 days-147 days 10 146.4 mmHg 2.53 8.0 vascular indwelling catheter method abdominal aorta 1814400 0 implanted at 84 days with 7 day recovery; Dataquest IV telemetry system (Data Sciences International) averaged over 21 days 12727 302
SHR.BN-(D2Rat114-D2Rat123)/Jk systolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 179.3 mmHg 3.5 16.79 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 12750 306
SBH.SBN-(D1Mgh2-D1Rat74)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait male 0 days 14 serial mean 158.0 mmHg 4.0 14.97 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12272 236
SHRSP/Izm percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content drinking water (1 %) (for 14 days) Kato N, et al., Hypertension 2003 DXCO;42(6):1191-7. cerebrovascular system integrity trait female 98 days 10 0.0 % ex vivo light microscopy MA:0000168 0 0 65292 115
WKY/Bbb systolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Hubner N, et al., Hypertension 1999 Oct;34(4 Pt 1):643-8 arterial blood pressure trait not specified 124 days 12 134.1 mmHg 0.98 3.4 radiotelemetry 0.0 0 67202 112
SHRSP.SHRSR-(Klk1-Mt1-ps1)/Bbb percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content diet (3.7 mg/g) (between 28 and 49 days) and controlled sodium content drinking water (1 %) (between 28 and 49 days) and controlled potassium content diet (6.3 mg/g) (between 28 and 49 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. cerebrovascular system integrity trait not specified 70 days-91 days 20 61.0 % ex vivo light microscopy 0.0 0 69121 1126
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 56 days 33 37.0 mg/d 2.44 14.0 Bradford protein assay 0.0 0 69220 1126
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 84 days 33 192.0 mmHg 1.22 7.0 tail cuff plethysmography 0.0 0 69168 1126
SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 84 days 31 181.0 mmHg 1.65 9.2 tail cuff plethysmography 0.0 0 69175 1126
SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 84 days) and controlled sodium content drinking water (1 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 126 days 31 208.0 mmHg 1.44 8.0 tail cuff plethysmography 0.0 0 69178 1126
SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 56 days 31 144.0 mmHg 1.98 11.0 tail cuff plethysmography 0.0 0 69180 1126
SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 70 days 31 166.0 mmHg 1.96 10.9 tail cuff plethysmography 0.0 0 69181 1126
SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 70 days) and controlled sodium content drinking water (1 %) (for 70 days) and controlled potassium content diet (6.3 mg/g) (for 70 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 112 days 28 199.0 mmHg 1.89 10.0 tail cuff plethysmography 0.0 0 69184 1126
SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 84 days) and controlled sodium content drinking water (1 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 126 days 25 201.0 mmHg 1.4 7.0 tail cuff plethysmography 0.0 0 69185 1126
SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 84 days 34 192.0 mmHg 0.79 4.6 tail cuff plethysmography 0.0 0 69198 1126
SHRSP.SHRSR-(Klk1-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 70 days 33 30.0 mg/d 0.92 5.3 Bradford protein assay 0.0 0 70258 1126
SHRSP.SHRSR-(Klk1-Mt1-ps1)/Bbb percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content diet (3.7 mg/g) (between 28 and 67 days) and controlled sodium content drinking water (1 %) (between 28 and 67 days) and controlled potassium content diet (6.3 mg/g) (between 28 and 67 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. cerebrovascular system integrity trait not specified 70 days-109 days 33 100.0 % ex vivo light microscopy 0.0 0 84575 1126
SHRSP.SHRSR-(Klk1-D1Mit3)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 70 days 31 75.0 mg/d 6.47 36.0 Bradford protein assay 0.0 0 84579 1126
SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 70 days 35 53.0 mg/d 1.27 7.5 Bradford protein assay 0.0 0 84583 1126
SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 70 days) and controlled sodium content drinking water (1 %) (for 70 days) and controlled potassium content diet (6.3 mg/g) (for 70 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 112 days 5 333.0 mg/d 34.44 77.0 Bradford protein assay 0.0 0 84586 1126
LH/Mav heart left ventricle weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. heart left ventricle mass male 119 days 6 2.88 mg/g 0.06 0.15 post excision weight measurement 0.0 0 103412 2824
LH/Mav aorta weight to body weight ratio perindopril (0.4 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. aorta mass male 119 days 8 12.5 mg/100g 0.6 1.7 post excision weight measurement 0.0 0 103415 2824
LH/Mav both kidneys wet weight to body weight ratio controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. kidney mass male 119 days 6 7.22 g/kg 0.34 0.83 post excision weight measurement 0.0 0 103422 2824
SBN/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (between 24 and 28 days) and deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait female 276 days-280 days 5 -3.0 mmHg 1.0 2.24 tail cuff plethysmography 0.0 0 n=5-7, change between age 9months and 10 months 106741 3039
SBH/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (between 24 and 28 days) and deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait male 276 days-280 days 5 49.0 mmHg 2.0 4.47 tail cuff plethysmography 0.0 0 n=5-7, change between age 9months and 10 months 106742 3039
SBH/Ygl systolic blood pressure controlled exposure to a foster mother of a different strain within the same species. (for 30 days) then controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait female 70 days 9 196.0 mmHg 2.0 6.0 tail cuff plethysmography 0.0 0 106755 3039
SBN/Ygl body weight deoxycorticosterone acetate (75 mg) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and darusentan (50 mg/kg/d) (for 56 days) Rothermund L, et al., Eur J Pharmacol. 2003 May 16;468(3):209-16. doi: 10.1016/s0014-2999(03)01714-x. body mass male 16 days 8 377.0 g 7.4 20.93 body weighing method 0.0 0 n=8-15 106645 3035
SBN/Ygl both kidneys wet weight to body weight ratio deoxycorticosterone acetate (75 mg) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and darusentan (50 mg/kg/d) (for 56 days) Rothermund L, et al., Eur J Pharmacol. 2003 May 16;468(3):209-16. doi: 10.1016/s0014-2999(03)01714-x. kidney mass male 16 days 8 2.7 g/kg 0.08 0.23 post excision weight measurement 0.0 0 n=8-15 106648 3035
SBN/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (between 24 and 28 days) and deoxycorticosterone acetate (75 mg) (between 24 and 28 days) then deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait male 360 days-364 days 5 0.0 mmHg 1.0 2.24 tail cuff plethysmography 0.0 0 n=5-7, change between age 12months and 13 months 106744 3039
SBH/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (between 24 and 28 days) and deoxycorticosterone acetate (75 mg) (between 24 and 28 days) then deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait male 360 days-364 days 5 52.0 mmHg 3.0 6.71 tail cuff plethysmography 0.0 0 n=5-7, change between age 12months and 13 months 106746 3039
SBH/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (between 24 and 28 days) and deoxycorticosterone acetate (75 mg) (for 90 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait female 108 days-112 days 5 55.0 mmHg 7.0 15.65 tail cuff plethysmography 0.0 0 n=5-7, change between age 3months and 4 months 106735 3039
SBN/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (between 24 and 28 days) and deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) then deoxycorticosterone acetate (75 mg) (for 90 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait male 276 days-280 days 5 0.0 mmHg 1.0 2.24 tail cuff plethysmography 0.0 0 n=5-7, change between age 9months and 10 months 106740 3039
SHRSP/A3N urine total protein excretion rate controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. urine protein amount male 210 days-224 days 0 251.0 mg/d 120.0 urine protein analysis 86400.0 0 metabolic cage; sulfosalicylic acid method 107473 3088
SHRSP/A3N urine total protein excretion rate controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. urine protein amount male 210 days-224 days 0 37.0 mg/d 15.0 urine protein analysis 86400.0 0 metabolic cage; sulfosalicylic acid method 107474 3088
SHRSP/A3N kidney glomerular lesion count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney glomerulus integrity trait male 210 days-224 days 0 31.0 /section 5.0 ex vivo light microscopy with histochemistry 0.0 0 107477 3088
SHRSP/A3NCrl timed urine volume controlled sodium content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. urine output male 99 days-148 days 9 79.0 ml/d 11.0 33.0 metabolic cage urine volume measurement method 86400.0 0 8 week HSFD plus treatment 8 week high salt high fat plus treatment 107055 3073
SHRSP/A3N end-diastolic volume controlled sodium content drinking water (1 %) (between 112 and 126 days) and controlled fat content diet (24.5 %) (between 112 and 126 days) and controlled carvedilol content diet (2400 ppm) (between 112 and 126 days) Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. cardiac output trait male 189 days-210 days 0 0.96 ml 0.02 transthoracic echocardiography 0.0 0 high salt high fat diet +carvedilol 107121 3075
SBH.SBN-(D1Mgh2-D1Rat101)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait female 0 days 11 serial mean 178.0 mmHg 4.0 13.27 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12245 236
SBN.SBH-(D1Rat27-D1Mit7)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait female 0 days 5 serial mean 130.0 mmHg 1.0 2.24 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12289 236
SHRSP/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 139.0 mmHg 3.4 5.89 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65660 613
WKY/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 138.9 mmHg 2.6 4.5 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65665 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 144.2 mmHg 4.5 7.79 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65697 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 118.2 mmHg 5.6 9.7 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65703 613
WKY.SHRSP-(Fst-Pklr)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 95.6 mmHg 7.1 12.3 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65720 613
SHRSP.WKY-(Klk1-D1Rat116)/Izm percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content drinking water (1 %) (for 28 days) Kato N, et al., Hypertension 2003 DXCO;42(6):1191-7. cerebrovascular system integrity trait male 112 days 13 0.0 % ex vivo light microscopy MA:0000168 0 0 65300 115
SHRSP/Bbb percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Nat Genet 1996 Aug;13(4):429-34 cerebrovascular system integrity trait both 84 days 30 100.0 % ex vivo light microscopy 0.0 0 69117 1125
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb percentage of study population developing cerebrovascular lesions during a period of time controlled sodium content diet (3.7 mg/g) (between 42 and 91 days) and controlled sodium content drinking water (1 %) (between 42 and 91 days) and controlled potassium content diet (6.3 mg/g) (between 42 and 91 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. cerebrovascular system integrity trait not specified 81 days-133 days 33 20.0 % ex vivo light microscopy 0.0 0 69123 1126
SHRSP/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 167.2 mmHg 5.2 9.01 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65655 613
WKY/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 4 continuous mean 96.8 mmHg 6.4 12.8 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65666 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 191.2 mmHg 3.4 5.89 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65675 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 154.9 mmHg 3.7 6.41 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65676 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 131.2 mmHg 5.5 9.53 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65678 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 202.1 mmHg 12.4 21.48 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65686 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 176.8 mmHg 6.3 10.91 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65689 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 117.4 mmHg 3.9 6.75 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65692 613
SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 178.3 mmHg 13.0 22.52 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65695 613
WKY.SHRSP-(Fst-Pklr)/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 83.1 mmHg 6.6 11.43 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65716 613
WKY.SHRSP-(Fst-Pklr)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 124.3 mmHg 1.6 2.77 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65719 613
WKY/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait male 137 days-140 days 6 continuous mean 168.7 mmHg 2.25 5.5 intra-aortic abdominal radiotelemetry abdominal aorta 0 11633 109
WKY/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (between 9 and 12 days) Clark JS, et al., Hypertension 1996 Nov;28(5):898-906 arterial blood pressure trait female 137 days-140 days 6 continuous mean 147.1 mmHg 3.76 9.2 intra-aortic abdominal radiotelemetry abdominal aorta 0 11634 109
WKY/Bbb heart rate controlled sodium content drinking water (1 %) (between 13 and 15 days) Kreutz R, et al., Circulation 1997 Aug 19;96(4):1078-81. heart pumping trait female 125 days-127 days 10 serial mean 380.0 beats/min 11.07 35.0 vascular indwelling catheter method femoral artery 0 3 sets of readings per day for two days 13287 334
WKY.SHRSP-(D1Rat200-D1Rat216)/Bbb systolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Monti J, et al., Hum Mol Genet 2003 Feb 15;12(4):435-9. arterial blood pressure trait male 110 days-124 days 12 128.65 mmHg 1.22 4.23 intra-aortic abdominal radiotelemetry 0 12657 281
SHR mean arterial blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 24 continuous mean 170.0 mmHg 3.0 14.7 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65348 306
SHR diastolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 24 continuous mean 144.0 mmHg 2.0 9.8 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65349 306
SHR systolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 24 continuous mean 196.6 mmHg 3.2 15.68 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 12749 306
SHR.BN-(D4Rat33-D4Rat54)/Jk systolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 188.7 mmHg 2.4 11.51 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 12752 306
SBH.SBN-(D1Rat137-D1Rat83)/Ygl systolic blood pressure controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil C, et al., Physiol Genomics 2003 Jan 15;12(2):85-95. arterial blood pressure trait male 0 days 6 serial mean 167.0 mmHg 4.0 9.8 tail cuff photoplethysmography 172800 0 photoelectric oscillatory detection device (IITC Life Science, Woodland Hills, CA) 12253 236
WKY/Bbb systolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Hubner N, et al., Hypertension 1999 Oct;34(4 Pt 1):643-8 arterial blood pressure trait not specified 124 days 11 129.2 mmHg 1.66 5.5 radiotelemetry 0.0 0 67200 112
WKY/Bbb diastolic blood pressure controlled sodium content drinking water (1 %) (for 12 days) Hubner N, et al., Hypertension 1999 Oct;34(4 Pt 1):643-8 arterial blood pressure trait not specified 124 days 12 91.5 mmHg 0.87 3.0 radiotelemetry 0.0 0 67206 112
WKY/Bbb mean arterial blood pressure controlled sodium content drinking water (1 %) (for 12 days) Hubner N, et al., Hypertension 1999 Oct;34(4 Pt 1):643-8 arterial blood pressure trait not specified 124 days 12 110.7 mmHg 0.89 3.1 radiotelemetry 0.0 0 67209 112
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 70 days 33 46.0 mg/d 2.61 15.0 Bradford protein assay 0.0 0 69221 1126
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 70 days) and controlled sodium content drinking water (1 %) (for 70 days) and controlled potassium content diet (6.3 mg/g) (for 70 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 112 days 29 241.0 mg/d 4.09 22.0 Bradford protein assay 0.0 0 69224 1126
SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 84 days 31 58.0 mg/d 5.03 28.0 Bradford protein assay 0.0 0 70245 1126
SHRSP/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 56 days 31 151.0 mmHg 1.44 8.0 tail cuff plethysmography 0.0 0 69162 1126
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 70 days) and controlled sodium content drinking water (1 %) (for 70 days) and controlled potassium content diet (6.3 mg/g) (for 70 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 112 days 29 202.0 mmHg 1.67 9.0 tail cuff plethysmography 0.0 0 69170 1126
SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 56 days 31 146.0 mmHg 1.26 7.0 tail cuff plethysmography 0.0 0 69173 1126
SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 98 days 31 197.0 mmHg 1.8 10.0 tail cuff plethysmography 0.0 0 69176 1126
SHRSP.SHRSR-(Klk1-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 84 days 20 192.0 mmHg 1.57 7.0 tail cuff plethysmography 0.0 0 69189 1126
SHRSP.SHRSR-(Klk1-D1Mit3)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 28 days) and controlled sodium content drinking water (1 %) (for 28 days) and controlled potassium content diet (6.3 mg/g) (for 28 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 70 days 31 190.0 mmHg 0.9 5.0 tail cuff plethysmography 0.0 0 69193 1126
SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 70 days) and controlled sodium content drinking water (1 %) (for 70 days) and controlled potassium content diet (6.3 mg/g) (for 70 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 112 days 5 198.0 mmHg 1.34 3.0 tail cuff plethysmography 0.0 0 69200 1126
SHRSP.SHRSR-(Klk1-D1Mit3)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 56 days 31 39.0 mg/d 4.31 24.0 Bradford protein assay 0.0 0 84578 1126
SHRSP.SHRSR-(Klk1-D1Mit3)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 42 days) and controlled sodium content drinking water (1 %) (for 42 days) and controlled potassium content diet (6.3 mg/g) (for 42 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 84 days 31 257.0 mg/d 15.98 89.0 Bradford protein assay 0.0 0 84580 1126
SHRSP.SHRSR-(D1Rat134-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and controlled potassium content diet (6.3 mg/g) (for 56 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 98 days 14 343.0 mg/d 16.04 60.0 Bradford protein assay 0.0 0 84585 1126
LH/Mav aorta weight to body weight ratio controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. aorta mass male 119 days 7 13.3 mg/100g 0.6 1.59 post excision weight measurement 0.0 0 103414 2824
LH/Mav both kidneys wet weight to body weight ratio controlled sodium content drinking water (2 %) (for 8 days) Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. kidney mass male 119 days 7 6.81 g/kg 0.19 0.5 post excision weight measurement 0.0 0 103419 2824
SBH/Ygl systolic blood pressure controlled exposure to a foster mother of a different strain within the same species. (for 30 days) then controlled sodium content drinking water (1 %) (for 28 days) and deoxycorticosterone acetate (25 mg) (for 28 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait male 70 days 5 195.0 mmHg 3.0 6.71 tail cuff plethysmography 0.0 0 106753 3039
SBN/Ygl body weight deoxycorticosterone acetate (75 mg) (for 56 days) and controlled sodium content drinking water (1 %) (for 56 days) and darusentan (50 mg/kg/d) (for 56 days) Rothermund L, et al., Eur J Pharmacol. 2003 May 16;468(3):209-16. doi: 10.1016/s0014-2999(03)01714-x. body mass male 16 days 8 345.0 g 6.9 19.52 body weighing method 0.0 0 n=8-15 106642 3035
SBN/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (for 30 days) and deoxycorticosterone acetate (25 mg) (for 30 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait female 52 days-56 days 5 6.0 mmHg 2.0 4.47 tail cuff plethysmography 0.0 0 n=5-7, change between age 1month and 2 months 106729 3039
SBH/Ygl absolute change in systolic blood pressure controlled sodium content drinking water (1 %) (between 24 and 28 days) and deoxycorticosterone acetate (75 mg) (between 24 and 28 days) then deoxycorticosterone acetate (75 mg) (for 90 days) Yagil Y and Yagil C, J Hypertens. 2000 Oct;18(10):1393-9. doi: 10.1097/00004872-200018100-00006. arterial blood pressure trait female 192 days-196 days 5 46.0 mmHg 4.0 8.94 tail cuff plethysmography 0.0 0 n=5-7, change between age 6 months and 7 months 106739 3039
SHRSP/A3N heart rate controlled sodium content drinking water (1 %) (between 112 and 126 days) and controlled fat content diet (24.5 %) (between 112 and 126 days) and controlled carvedilol content diet (2400 ppm) (between 112 and 126 days) Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. heart pumping trait male 189 days-210 days 0 254.0 beats/min 10.0 transthoracic echocardiography 0.0 0 high salt high fat diet +carvedilol 107129 3075
SHRSP/A3N plasma aldosterone level controlled sodium content drinking water (1 %) (for 112 days) and controlled fat content diet (24.5 %) (for 112 days) Willette RN, etal., J Cardiovasc Pharmacol. 2001 Oct;38(4):606-17. doi: 10.1097/00005344-200110000-00013. blood aldosterone amount male 182 days-210 days 8 347.0 pg/ml 72.0 203.65 radioimmunoassay 0.0 0 107938 3100
SHRSP/A3N kidney tubule regeneration foci count controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. kidney integrity trait male 210 days-224 days 0 1.9 /section 1.3 ex vivo light microscopy with histochemistry 0.0 0 foci of tubular regeneration 107486 3088
SHRSP/A3N end-diastolic volume controlled sodium content drinking water (1 %) (between 112 and 126 days) and controlled fat content diet (24.5 %) (between 112 and 126 days) Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. cardiac output trait male 189 days-210 days 0 0.69 ml 0.05 transthoracic echocardiography 0.0 0 high salt high fat diet 107122 3075
SHRSP/A3N end-systolic volume controlled sodium content drinking water (1 %) (between 112 and 126 days) and controlled fat content diet (24.5 %) (between 112 and 126 days) and controlled carvedilol content diet (2400 ppm) (between 112 and 126 days) Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. cardiac output trait male 189 days-210 days 0 0.28 ml 0.03 transthoracic echocardiography 0.0 0 high salt high fat diet +carvedilol 107125 3075
SHRSP/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 152.9 mmHg 5.2 9.01 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65654 613
SHRSP/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 134.6 mmHg 3.5 6.06 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65657 613
WKY/Gcrc diastolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 92.0 mmHg 2.9 5.02 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65668 613
SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 180.7 mmHg 2.5 4.33 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65674 613
SHRSP/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to darkness Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait male 126 days-147 days 3 continuous mean 156.4 mmHg 6.5 11.26 intra-aortic abdominal radiotelemetry 1814400 0 Nights (7 PM to 7 AM) 65683 613
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc mean arterial blood pressure controlled sodium content drinking water (1 %) (for 21 days) and controlled exposure to ambient light Jeffs B, et al., Hypertension 2000 Jan;35(1 Pt 2):179-87. arterial blood pressure trait female 126 days-147 days 3 continuous mean 112.1 mmHg 7.2 12.47 intra-aortic abdominal radiotelemetry 1814400 0 Days (7 AM to 7 PM) 65708 613
SHRSR/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 56 days 18 31.0 mg/d 3.3 14.0 Bradford protein assay 0.0 0 69209 1126
SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 84 days) and controlled sodium content drinking water (1 %) (for 84 days) and controlled potassium content diet (6.3 mg/g) (for 84 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 126 days 26 294.0 mg/d 2.94 15.0 Bradford protein assay 0.0 0 69225 1126
SHRSR.SHRSP-(D1Rat134-Mt1-ps1)/Bbb urine total protein excretion rate controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. total urine protein amount not specified 56 days 31 11.0 mg/d 0.27 1.5 Bradford protein assay 0.0 0 70250 1126
SHRSR/Bbb systolic blood pressure controlled sodium content diet (3.7 mg/g) (for 14 days) and controlled sodium content drinking water (1 %) (for 14 days) and controlled potassium content diet (6.3 mg/g) (for 14 days) Rubattu S, et al., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11. arterial blood pressure trait not specified 56 days 18 139.0 mmHg 1.65 7.0 tail cuff plethysmography 0.0 0 69126 1126