COP/OlaHsd |
post-insult time to mammary tumor formation |
17 beta-estradiol (27.5 mg) (between 212 and 330 days) |
Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 |
mammary gland integrity trait |
female |
212 days-330 days |
7 |
|
|
208.0 |
d |
7.56 |
20.0 |
manual palpation method |
|
|
0 |
|
|
mean |
|
11749 |
144 |
COP/OlaHsd |
plasma free fatty acids level |
control condition |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
blood free fatty acid amount |
not specified |
105 days
| 14 |
|
|
0.12 |
mmol/l |
0.01 |
0.04 |
spectrophotometry |
0.0 |
|
0 |
|
|
|
|
68563 |
933 |
COP/OlaHsd |
plasma triglyceride level |
control condition |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
blood triglyceride amount |
not specified |
105 days
| 14 |
|
|
0.58 |
mmol/l |
0.09 |
0.35 |
spectrophotometry |
0.0 |
|
0 |
|
|
|
|
68557 |
933 |
COP/OlaHsd |
both kidneys wet weight |
control condition |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
kidney mass |
not specified |
105 days
| 15 |
|
|
1.84 |
g |
0.05 |
0.19 |
post excision weight measurement |
0.0 |
|
0 |
|
|
|
|
68501 |
933 |
COP/OlaHsd |
liver weight to body weight ratio |
control condition |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
liver mass |
not specified |
105 days
| 15 |
|
|
35.3 |
g/kg |
0.45 |
1.74 |
post excision weight measurement |
0.0 |
|
0 |
|
|
|
|
68513 |
933 |
COP/OlaHsd |
heart wet weight |
running on inclined treadmill (10 m/min) (for 0.1 hours) |
Lee SJ, et al., Physiol Genomics 2005 Jul 20;. |
heart mass |
male |
105 days
| 4 |
|
|
0.57 |
g |
|
|
post excision weight measurement |
0.0 |
|
0 |
|
|
|
|
13337 |
345 |
COP/OlaHsd |
heart weight to body weight ratio |
running on inclined treadmill (10 m/min) (for 0.1 hours) |
Lee SJ, et al., Physiol Genomics 2005 Jul 20;. |
heart mass |
male |
105 days
| 4 |
|
|
2.17 |
g/kg |
|
|
post excision weight measurement |
0.0 |
|
0 |
|
|
|
|
13339 |
345 |
COP/OlaHsd |
percentage of study population developing mammary tumors during a period of time |
17 beta-estradiol (27.5 mg) (between 212 and 330 days) |
Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 |
mammary gland integrity trait |
female |
212 days-330 days |
7 |
|
|
43.8 |
% |
|
|
manual palpation method |
0 |
|
0 |
|
|
mean |
|
66113 |
144 |
COP/OlaHsd |
mammary tumor number |
17 beta-estradiol (27.5 mg) (between 212 and 330 days) |
Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 |
mammary gland integrity trait |
female |
271 days-397 days |
20 |
|
|
0.4 |
null |
0.13 |
0.6 |
manual palpation method |
0 |
|
0 |
|
|
|
|
11753 |
144 |
COP/OlaHsd |
maximum distance run on treadmill |
running on treadmill (10 m/min) |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
exercise endurance trait |
male |
77 days
| 15 |
|
geometric mean |
406.2 |
m |
17.2 |
66.62 |
treadmill method with electric shock source |
0.0 |
|
0 |
|
|
mg/g |
|
69249 |
933 |
COP/OlaHsd |
plasma insulin level |
fasting (for 16 hours) |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
blood insulin amount |
not specified |
105 days
| 10 |
|
|
29.12 |
mU/l |
5.72 |
18.09 |
enzyme linked immunosorbent assay |
0.0 |
|
0 |
|
|
|
|
68572 |
933 |
COP/OlaHsd |
maximum distance run on treadmill |
running on inclined treadmill (10 m/min) |
Ways JA, et al., Genomics 2002 Jul;80(1):13-20. |
exercise endurance trait |
male |
77 days-84 days |
0 |
|
|
345.0 |
m |
17.0 |
|
treadmill method with electric shock source and automated tracking |
0.0 |
|
0 |
|
timing method |
|
|
68477 |
932 |
COP/OlaHsd |
heart wet weight |
control condition |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
heart mass |
not specified |
105 days
| 15 |
|
|
0.76 |
g |
0.01 |
0.04 |
post excision weight measurement |
0.0 |
|
0 |
|
|
|
|
68505 |
933 |
COP/OlaHsd |
pancreas weight to body weight ratio |
control condition |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
pancreas mass |
not specified |
105 days
| 15 |
|
|
2.29 |
mg/g |
0.12 |
0.46 |
post excision weight measurement |
0.0 |
|
0 |
|
|
mg/g |
|
68509 |
933 |
COP/OlaHsd |
both kidneys wet weight to body weight ratio |
control condition |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
kidney mass |
not specified |
105 days
| 15 |
|
|
6.8 |
g/kg |
0.14 |
0.54 |
post excision weight measurement |
0.0 |
|
0 |
|
|
|
|
68521 |
933 |
COP/OlaHsd |
maximum body weight loss to initial body weight ratio |
arterial catheter implantation (for 1 days) |
Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. |
body mass |
male |
89 days-95 days |
10 |
|
|
3.9 |
% |
1.0 |
3.16 |
body weighing method |
0.0 |
arterial catheter implantation |
1 |
days |
|
|
|
107173 |
3077 |
COP/OlaHsd |
hematocrit |
arterial catheter implantation (for 1 days) then controlled hemorrhage (for 0 hours) |
Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. |
erythrocyte quantity |
male |
89 days-95 days |
10 |
|
|
36.9 |
% |
1.7 |
5.38 |
microhematocrit tube assay with visual assessment |
0.0 |
|
0 |
|
|
|
initial hematocrit, final hematocrit, change in hematocrit |
107234 |
3077 |
COP/OlaHsd |
volume of blood removed to total prehemorrhagic blood volume ratio |
arterial catheter implantation (for 1 days) then controlled hemorrhage (for 0.4 hours) |
Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. |
blood amount |
male |
89 days-95 days |
10 |
5.83 mL/100 g of body weight |
|
57.1 |
% |
0.4 |
1.26 |
body weighing method |
|
|
0 |
|
|
|
|
109125 |
3077 |
COP/OlaHsd |
maximum distance run on treadmill |
running on treadmill (10 m/min) |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
exercise endurance trait |
male |
77 days
| 15 |
|
|
571.9 |
m |
27.5 |
106.51 |
treadmill method with electric shock source |
0.0 |
|
0 |
|
|
mg/g |
|
69245 |
933 |
COP/OlaHsd |
plasma free fatty acids level |
fasting (for 16 hours) |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
blood free fatty acid amount |
not specified |
105 days
| 20 |
|
|
0.23 |
mmol/l |
0.02 |
0.09 |
spectrophotometry |
0.0 |
|
0 |
|
|
|
|
68566 |
933 |
COP/OlaHsd |
heart left ventricle weight to body weight ratio |
control condition |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
heart left ventricle mass |
not specified |
105 days
| 15 |
|
|
1.75 |
mg/g |
0.02 |
0.08 |
post excision weight measurement |
0.0 |
|
0 |
|
|
|
|
68517 |
933 |
COP/OlaHsd |
mean arterial blood pressure |
arterial catheter implantation (for 1 days) |
Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. |
arterial blood pressure trait |
male |
89 days-95 days |
10 |
|
|
121.0 |
mmHg |
3.0 |
9.49 |
vascular fluid filled catheter |
300.0 |
|
0 |
|
5-second intervals |
|
Initial MAP |
107331 |
3077 |
COP/OlaHsd |
body weight |
running on inclined treadmill (10 m/min) (for 0.1 hours) |
Lee SJ, et al., Physiol Genomics 2005 Jul 20;. |
body mass |
male |
105 days
| 4 |
|
|
260.5 |
g |
|
|
body weighing method |
0.0 |
|
0 |
|
|
|
|
13335 |
345 |
COP/OlaHsd |
pancreas wet weight |
control condition |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
pancreas mass |
not specified |
105 days
| 15 |
|
|
0.62 |
g |
0.03 |
0.12 |
post excision weight measurement |
0.0 |
|
0 |
|
|
|
|
68489 |
933 |
COP/OlaHsd |
maximum distance run on treadmill |
running on inclined treadmill (10 m/min) (for 0.1 hours) |
Lee SJ, et al., Physiol Genomics 2005 Jul 20;. |
exercise endurance trait |
male |
77 days-82 days |
4 |
|
|
392.0 |
m |
|
|
treadmill method with electric shock source and automated tracking |
0.0 |
|
0 |
|
with pedometer/odometer |
maximum distance run on treadmill |
|
68084 |
345 |
COP/OlaHsd |
plasma glucose level |
fasting (for 16 hours) |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
blood glucose amount |
not specified |
105 days
| 20 |
|
|
119.2 |
mg/dl |
4.34 |
19.41 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
|
0 |
|
|
|
|
68569 |
933 |
COP/OlaHsd |
absolute change in hematocrit |
arterial catheter implantation (for 1 days) then controlled hemorrhage (between 0 and 0.4 hours) |
Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. |
erythrocyte quantity |
male |
89 days-95 days |
10 |
|
|
8.9 |
% |
1.0 |
3.16 |
microhematocrit tube assay with visual assessment |
0.0 |
|
0 |
|
|
|
initial hematocrit, final hematocrit, change in hematocrit |
107267 |
3077 |
COP/OlaHsd |
mammary tumor number |
7,12-dimethyltetraphene (DMBA) (65 mg/kg) |
Haag JD, et al., Cancer Res 2003 Sep 15;63(18):5808-12 |
mammary gland integrity trait |
female |
155 days-160 days |
16 |
|
|
0.25 |
null |
0.1 |
0.4 |
necropsy |
|
|
0 |
|
|
3X3 mm diameter or larger |
|
11747 |
143 |
COP/OlaHsd |
post-insult time to mammary tumor formation |
17 beta-estradiol (27.5 mg) (between 212 and 330 days) |
Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 |
mammary gland integrity trait |
female |
212 days-330 days |
7 |
|
median |
195.0 |
d |
|
|
manual palpation method |
|
|
0 |
|
|
median |
|
11751 |
144 |
COP/OlaHsd |
plasma triglyceride level |
fasting (for 16 hours) |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
blood triglyceride amount |
not specified |
105 days
| 20 |
|
|
0.29 |
mmol/l |
0.02 |
0.1 |
spectrophotometry |
0.0 |
|
0 |
|
|
|
|
68560 |
933 |
COP/OlaHsd |
heart weight to body weight ratio |
control condition |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
heart mass |
not specified |
105 days
| 15 |
|
|
2.76 |
g/kg |
0.03 |
0.12 |
post excision weight measurement |
0.0 |
|
0 |
|
|
|
|
68525 |
933 |
COP/OlaHsd |
food intake weight to body weight ratio |
arterial catheter implantation (for 1 days) |
Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. |
eating behavior trait |
male |
89 days-95 days |
10 |
|
|
5.1 |
g/d/100g |
0.4 |
1.26 |
food intake measuring method |
0.0 |
arterial catheter implantation |
1 |
days |
|
|
Food consumed
(g) postsurgery
per 100 g BW |
107140 |
3077 |
COP/OlaHsd |
water intake drink rate to body weight ratio |
arterial catheter implantation (for 1 days) |
Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. |
drinking behavior trait |
male |
89 days-95 days |
10 |
|
|
0.47 |
ml/d/kg |
0.08 |
0.25 |
drink intake measuring method |
0.0 |
arterial catheter implantation |
1 |
days |
|
|
Water consumed
(g) postsurgery
per 100 g BW |
107156 |
3077 |
COP/OlaHsd |
liver wet weight |
control condition |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
liver mass |
not specified |
105 days
| 15 |
|
|
9.55 |
g |
0.16 |
0.62 |
post excision weight measurement |
0.0 |
|
0 |
|
|
|
|
68493 |
933 |
COP/OlaHsd |
abdominal subcutaneous fat pad weight |
control condition |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
subcutaneous adipose mass |
not specified |
105 days
| 15 |
|
|
1.27 |
g |
0.11 |
0.43 |
post excision weight measurement |
0.0 |
|
0 |
|
|
|
|
69255 |
933 |
COP/OlaHsd |
body weight |
control condition |
Ways JA, et al., Genomics 2002 Jul;80(1):13-20. |
body mass |
male |
77 days-84 days |
0 |
|
|
228.0 |
g |
7.0 |
|
body weighing method |
|
|
0 |
|
timing method |
|
|
84622 |
932 |
COP/OlaHsd |
maximum time spent running to exhaustion on treadmill |
running on inclined treadmill (10 m/min) |
Ways JA, et al., Genomics 2002 Jul;80(1):13-20. |
exercise endurance trait |
male |
77 days-84 days |
0 |
|
|
22.7 |
min |
1.0 |
|
treadmill method with electric shock source and automated tracking |
0.0 |
|
0 |
|
timing method |
time spent running maximum distance on treadmill |
|
68478 |
932 |
COP/OlaHsd |
abdominal fat pad weight |
control condition |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
abdominal fat pad mass |
not specified |
105 days
| 15 |
|
|
4.95 |
g |
0.22 |
0.85 |
post excision weight measurement |
0.0 |
|
0 |
|
|
|
|
69253 |
933 |
COP/OlaHsd |
body weight |
control condition |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
body mass |
not specified |
105 days
| 15 |
|
|
271.0 |
g |
5.5 |
21.3 |
body weighing method |
0.0 |
|
0 |
|
|
|
|
68485 |
933 |
COP/OlaHsd |
heart left ventricle wet weight |
control condition |
Ways JA, et al., Physiol Genomics. 2006 Dec 19;. |
heart left ventricle mass |
not specified |
105 days
| 15 |
|
|
0.49 |
g |
0.01 |
0.04 |
post excision weight measurement |
0.0 |
|
0 |
|
|
|
|
68497 |
933 |
COP/OlaHsd |
hematocrit |
arterial catheter implantation (for 1 days) then controlled hemorrhage (for 0.4 hours) |
Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53. |
erythrocyte quantity |
male |
89 days-95 days |
10 |
|
|
29.7 |
% |
1.1 |
3.48 |
microhematocrit tube assay with visual assessment |
0.0 |
|
0 |
|
|
|
initial hematocrit, final hematocrit, change in hematocrit |
107251 |
3077 |