Phenominer Database Results (591 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91 days-93 days 35 continuous mean 173.0 mmHg 7.0 41.41 vascular indwelling catheter method femoral artery 259200.0 0 3 h per day decrease 66140 229
SS/JrHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 39.0 mmHg 6.0 21.63 vascular indwelling catheter method left femoral artery 0.0 0 67302 151
LH/MavRrrc absolute change in diastolic blood pressure trimethaphan camsylate (10 mg/kg) (for 0.2 hours) Vincent M, et al., J Clin Invest 1997 Oct 15;100(8):2000-6 arterial blood pressure trait not specified 203 days-217 days 16 serial mean -55.6 mmHg 1.83 7.3 vascular indwelling catheter method abdominal aorta 3600 0 65266 121
LN/MavRrrc absolute change in systolic blood pressure darodipine (200 ug/kg) (for 0.2 hours) Vincent M, et al., J Clin Invest 1997 Oct 15;100(8):2000-6 arterial blood pressure trait not specified 203 days-217 days 15 serial mean -62.1 mmHg 3.69 14.3 vascular indwelling catheter method abdominal aorta 3600 0 65267 121
LN/MavRrrc absolute change in diastolic blood pressure darodipine (200 ug/kg) (for 0.2 hours) Vincent M, et al., J Clin Invest 1997 Oct 15;100(8):2000-6 arterial blood pressure trait not specified 203 days-217 days 15 serial mean -40.9 mmHg 3.02 11.7 vascular indwelling catheter method abdominal aorta 3600 0 65269 121
SHR diastolic blood pressure control condition Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 138.0 mmHg 2.0 9.59 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65351 306
WKY/NCruk systolic blood pressure control condition Frantz S, et al., Hypertension 2001 Aug;38(2):216-21 arterial blood pressure trait male 196 days 19 121.8 mmHg 2.73 11.9 vascular indwelling catheter method 0 beat to beat for 1 hour 11324 72
WKY.SHR-(D1Wox19-D1Mit2)/Njs systolic blood pressure control condition Frantz S, et al., Hypertension 2001 Aug;38(2):216-21 arterial blood pressure trait male 196 days 20 144.0 mmHg 1.9 8.5 vascular indwelling catheter method 0 beat to beat for 1 hour 11325 72
WKY.SHR-(D1Rat56-D1M7Mit206)/Njs systolic blood pressure control condition Frantz S, et al., Hypertension 2001 Aug;38(2):216-21 arterial blood pressure trait male 196 days 15 139.6 mmHg 3.1 12.0 vascular indwelling catheter method 0 beat to beat for 1 hour 11326 72
WKY.SHR-(D1Rat236-D1M7Mit206)/Njs systolic blood pressure control condition Frantz S, et al., Hypertension 2001 Aug;38(2):216-21 arterial blood pressure trait male 196 days 15 143.4 mmHg 2.12 8.2 vascular indwelling catheter method 0 beat to beat for 1 hour 11327 72
SHR.WKY-(D1Wox34-D1Rat164)/Njs systolic blood pressure control condition Frantz S, et al., Hypertension 2001 Aug;38(2):216-21 arterial blood pressure trait male 196 days 18 190.9 mmHg 2.62 11.1 vascular indwelling catheter method 0 beat to beat for 1 hour 11330 72
SHR.WKY-(D1Wox34-Sah)/Njs systolic blood pressure control condition Frantz S, et al., Hypertension 2001 Aug;38(2):216-21 arterial blood pressure trait male 196 days 20 179.2 mmHg 3.15 14.1 vascular indwelling catheter method 0 beat to beat for 1 hour 11331 72
BN.GH-(D6Mit12-D6Rat15)/Mcwi mean arterial blood pressure control condition Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 127 days-143 days 16 serial mean 97.3 mmHg 2.75 11.0 vascular indwelling catheter method left femoral artery and vein 4 hrs/day for 3 days 0 microrenathane catheter; recover for 1 week after surgery 11535 101
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days-94 days 12 serial mean 142.0 mmHg 5.0 17.32 vascular indwelling catheter method left femoral artery 0 0 65467 151
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 93 days 12 serial mean 427.0 beats/min 6.0 20.78 vascular indwelling catheter method left femoral artery 0 0 65469 151
LEW mean arterial blood pressure losartan (10 mg/kg) (for 0.2 hours) then pentolinium (5 mg/kg) (for 0.1 hours) Ueno T, et al., J Mol Med 2003 Jan;81(1):51-60. Epub 2002 Nov 21. arterial blood pressure trait both 151 days-181 days 21 continuous mean 45.0 mmHg 2.0 9.17 vascular indwelling catheter method carotid artery, jugular vein 1800 0 64703 249
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) then controlled exposure to ambient light (for 12 hours) then controlled exposure to darkness (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91 days-93 days 35 continuous mean 7.0 mmHg 7.0 41.41 vascular indwelling catheter method femoral artery 0.0 0 left femoral artery decrease 64931 229
HTG systolic blood pressure control condition Ueno T, et al., Physiol Genomics 2004 Mar 12;17(1):38-47. arterial blood pressure trait female 151 days-181 days 10 149.3 mmHg 2.7 8.54 vascular indwelling catheter method carotid artery and jugular vein 0 polyethylene catheter 11713 120
LEW systolic blood pressure control condition Ueno T, et al., Physiol Genomics 2004 Mar 12;17(1):38-47. arterial blood pressure trait male 151 days-181 days 9 124.3 mmHg 3.9 11.7 vascular indwelling catheter method carotid artery and jugular vein 0 polyethylene catheter 11715 120
LEW systolic blood pressure control condition Ueno T, et al., Physiol Genomics 2004 Mar 12;17(1):38-47. arterial blood pressure trait female 151 days-181 days 12 138.8 mmHg 2.8 9.7 vascular indwelling catheter method carotid artery and jugular vein 0 polyethylene catheter 11717 120
LN/MavRrrc systolic blood pressure control condition Vincent M, et al., J Clin Invest 1997 Oct 15;100(8):2000-6 arterial blood pressure trait not specified 203 days-217 days 15 serial mean 134.0 mmHg 1.68 6.5 vascular indwelling catheter method abdominal aorta 3600 0 11719 121
BN.GH-(D2Rat22-D2Mgh11)/Mcwi heart rate control condition Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart pumping trait male 127 days-143 days 19 serial mean 349.8 beats/min 7.34 32.0 vascular indwelling catheter method left femoral artery and vein 4 hrs/day for 3 days 0 microrenathane catheter; recover for 1 week after surgery 11531 101
SHR systolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 24 continuous mean 196.6 mmHg 3.2 15.68 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 12749 306
SHR.BN-(D2Rat226-D2Rat294)/Jk systolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 22 continuous mean 177.6 mmHg 2.0 9.38 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 12751 306
SHR.WKY-(D1Wox19-D1Wox34)/Njs systolic blood pressure control condition Frantz SA, et al., Hypertension 1998 Oct;32(4):639-46 arterial blood pressure trait male 175 days 31 continuous mean 220.9 mmHg 2.57 14.3 vascular indwelling catheter method aorta 0 11908 206
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91 days-94 days 42 continuous mean 109.0 mmHg 2.0 12.96 vascular indwelling catheter method femoral artery 259200.0 0 3 h per day 12012 229
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) and controlled exposure to darkness (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91 days-93 days 42 continuous mean 114.0 mmHg 4.0 25.92 vascular indwelling catheter method femoral artery 14400.0 0 left femoral artery 12016 229
BN.GH-(D2Rat22-D2Mgh11)/Mcwi diastolic blood pressure control condition Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 127 days-143 days 19 serial mean 86.9 mmHg 2.23 9.7 vascular indwelling catheter method left femoral artery and vein 4 hrs/day for 3 days 0 microrenathane catheter; recover for 1 week after surgery 11530 101
HTG mean arterial blood pressure control condition Ueno T, et al., J Mol Med 2003 Jan;81(1):51-60. Epub 2002 Nov 21. arterial blood pressure trait both 151 days-181 days 19 continuous mean 125.0 mmHg 3.0 13.08 vascular indwelling catheter method carotid artery, jugular vein 1800 0 12391 249
WKY/Bbb heart rate control condition Kreutz R, et al., Circulation 1997 Aug 19;96(4):1078-81. heart pumping trait female 112 days 12 serial mean 408.0 beats/min 8.95 31.0 vascular indwelling catheter method femoral artery 0 3 sets of readings per day for two days 13284 334
WKY/Bbb heart rate controlled sodium content drinking water (1 %) (between 13 and 15 days) Kreutz R, et al., Circulation 1997 Aug 19;96(4):1078-81. heart pumping trait female 125 days-127 days 10 serial mean 380.0 beats/min 11.07 35.0 vascular indwelling catheter method femoral artery 0 3 sets of readings per day for two days 13287 334
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 89 days-92 days 20 serial mean 437.0 beats/min 6.0 26.83 vascular indwelling catheter method left femoral artery 0 13310 151
SHR.BN-(D2Rat226-D2Rat294)/Jk diastolic blood pressure control condition Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 22 continuous mean 127.0 mmHg 3.0 14.07 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65399 306
SHR.BN-(D2Rat226-D2Rat294)/Jk mean arterial blood pressure control condition Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 22 continuous mean 148.0 mmHg 2.0 9.38 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65401 306
SHR.BN-(D4Rat33-D4Rat54)/Jk diastolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 136.0 mmHg 2.0 9.59 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65408 306
SHR.BN-(D16Rat87-D16Mgh1)/Jk diastolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 130.0 mmHg 3.0 14.39 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65414 306
SHR.BN-(D16Rat87-D16Mgh1)/Jk mean arterial blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 154.0 mmHg 3.0 14.39 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65415 306
SHR.BN-(D2Rat226-D2Rat294)/Jk heart rate controlled sodium content diet (1 %) (for 14 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. heart pumping trait male 87 days 22 continuous mean 350.0 beats/min 4.0 18.76 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65421 306
LH/MavRrrc absolute change in systolic blood pressure losartan (20 mg/kg) (for 0.7 hours) Vincent M, et al., J Clin Invest 1997 Oct 15;100(8):2000-6 arterial blood pressure trait not specified 203 days-217 days 16 serial mean -6.31 mmHg 2.58 10.33 vascular indwelling catheter method abdominal aorta 3600 0 65260 121
BN-Lx/Cub diastolic blood pressure control condition Pravenec M, et al., J Hypertens 1989 Mar;7(3):217-21. arterial blood pressure trait male 0 days 8 93.0 mmHg 3.0 8.49 vascular indwelling catheter method carotid artery segment 0.0 0 66037 651
F344/NHsd mean arterial blood pressure control condition Zhao L et al., 2001, Circulation, 103(3), 442-7 arterial blood pressure trait male 105 days 12 median 121.0 mmHg vascular indwelling catheter method left common carotid artery 0 0 66127 102
WKY/NCruk mean arterial blood pressure control condition Zhao L et al., 2001, Circulation, 103(3), 442-7 arterial blood pressure trait male 105 days 12 median 91.0 mmHg vascular indwelling catheter method left common carotid artery 0 0 66129 102
BN.GH-(D2Rat22-D2Mgh11)/Mcwi change in mean arterial blood pressure to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 130 days-144 days 11 0.66 mmHg/ng/kg/min 0.03 0.09 vascular indwelling catheter method left femoral artery and vein 0.0 0 microrenathane catheter; recover for 1 week after surgery slope of map response curve 68340 101
SHRSP/Izm heart rate control condition Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. heart pumping trait male 98 days 6 287.0 beats/min 5.0 12.25 vascular indwelling catheter method 0.0 0 69088 1120
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd time constant of left ventricular pressure decay sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 7.5 ms 0.6 1.34 vascular indwelling catheter method 0.0 0 68918 1014
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 126.0 mmHg 4.1 14.78 vascular indwelling catheter method left femoral artery 120.0 0 69528 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (100 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 132.9 mmHg 3.8 17.41 vascular indwelling catheter method left femoral artery 120.0 0 69531 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 139.1 mmHg 3.6 16.5 vascular indwelling catheter method left femoral artery 120.0 0 69533 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (0.5 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 141.7 mmHg 7.4 26.68 vascular indwelling catheter method left femoral artery 120.0 0 69536 151
Crl:WI systolic blood pressure controlled NG-nitroarginine methyl ester content drinking water (20 mg/kg/d) (between 0 and 672 hours) Blanc J, et al., J Hypertens. 1999 Nov;17(11):1527-34. arterial blood pressure trait male 0 days 15 185.0 mmHg 5.0 19.36 vascular indwelling catheter method 0.0 0 70417 1418
WKY/Cfd left ventricular end-systolic blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 115.5 mmHg 4.4 9.84 vascular indwelling catheter method 0.0 0 68862 1014
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd left ventricular end-systolic blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 134.3 mmHg 5.9 13.19 vascular indwelling catheter method 0.0 0 68866 1014
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd left ventricular end-systolic blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 120.3 mmHg 2.4 5.37 vascular indwelling catheter method 0.0 0 68872 1014
WKHA/Cfd maximum rate of positive change in left ventricular blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 10070.0 mmHg/s 611.0 1366.24 vascular indwelling catheter method 0.0 0 68899 1014
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd maximum rate of positive change in left ventricular blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 9210.0 mmHg/s 296.0 661.88 vascular indwelling catheter method 0.0 0 68900 1014
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 93 days 10 serial mean 146.5 mmHg 5.6 17.71 vascular indwelling catheter method left femoral artery 10800.0 0 69518 151
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 93 days 11 serial mean 446.8 beats/min 9.7 32.17 vascular indwelling catheter method left femoral artery 10800.0 0 69520 151
WKY/NCrl systolic blood pressure controlled exposure to ambient light (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 112 days 7 125.9 mmHg 0.49 1.3 vascular indwelling catheter method left common carotid artery 0.0 0 daytime (7 AM - 7 PM) 70081 1281
WKY/NCrl systolic blood pressure controlled exposure to darkness (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 112 days 7 130.0 mmHg 0.57 1.5 vascular indwelling catheter method left common carotid artery 0.0 0 nighttime (7 PM - 7 AM) 70082 1281
WKY.SHR-(D1Mgh14-D1Rat77)/Iwai diastolic blood pressure controlled sodium content diet (8 %) (for 14 days) then controlled exposure to ambient light (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 126 days 8 90.6 mmHg 1.27 3.6 vascular indwelling catheter method left common carotid artery 0.0 0 daytime (7 AM - 7 PM) 70095 1281
Crl:CD(SD) mean arterial blood pressure control condition O'Meara CC, et al., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5. arterial blood pressure trait male 189 days 6 serial mean 93.0 mmHg 5.0 12.25 vascular indwelling catheter method femoral artery 10800.0 0 1day/week 96901 1738
SHRSP/Izm percent change in mean arterial blood pressure air-jet exposure (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 28.0 % 2.0 4.9 vascular indwelling catheter method 0.0 0 84544 1120
WKY/Izm heart rate control condition Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. heart pumping trait male 98 days 6 306.0 beats/min 12.0 29.39 vascular indwelling catheter method 0.0 0 84549 1120
WKY/Izm absolute change in mean arterial blood pressure air-jet exposure (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 23.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84556 1120
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in heart rate air-jet exposure (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. heart pumping trait male 98 days 6 105.0 beats/min 12.0 29.39 vascular indwelling catheter method 0.0 0 84559 1120
WKY/Izm absolute change in mean arterial blood pressure vehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 27.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 84566 1120
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then V1-Cal (1 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 432.0 beats/min 10.0 24.49 vascular indwelling catheter method 0.0 0 104773 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then V1-Cal (1 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 110.0 mmHg 5.0 12.25 vascular indwelling catheter method 0.0 0 104779 2988
SD-Trpv1em1Sage-/- mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then V1-Cal (1 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 114.0 mmHg 7.0 17.15 vascular indwelling catheter method 0.0 0 104782 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then dihydrocapsaicin (0.3 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 363.0 beats/min 9.0 22.05 vascular indwelling catheter method 0.0 0 104796 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then V1-Cal (1 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 400.0 beats/min 8.0 19.6 vascular indwelling catheter method 0.0 0 104797 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion then Capsazepine (3 mg/kg) (for 0.7 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 5 366.0 beats/min 7.0 15.65 vascular indwelling catheter method 0.0 0 104673 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then dihydrocapsaicin (0.1 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 373.0 beats/min 10.0 24.49 vascular indwelling catheter method 0.0 0 104694 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then dihydrocapsaicin (0.3 mg/kg) (for 3.2 hours) and Capsazepine (3 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 383.0 beats/min 16.0 39.19 vascular indwelling catheter method 0.0 0 104707 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then dihydrocapsaicin (0.3 mg/kg) (for 3.2 hours) and cyclosporine A (2.5 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 409.0 beats/min 14.0 34.29 vascular indwelling catheter method 0.0 0 104708 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then cyclosporine A (2.5 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 399.0 beats/min 14.0 34.29 vascular indwelling catheter method 0.0 0 104710 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then Capsazepine (3 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 5 108.0 mmHg 12.0 26.83 vascular indwelling catheter method 0.0 0 104718 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then dihydrocapsaicin (0.3 mg/kg) (for 3.2 hours) and cyclosporine A (2.5 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 68.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 104726 2988
SD-Trpv1em1Sage-/- mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 122.0 mmHg 5.0 12.25 vascular indwelling catheter method 0.0 0 104757 2988
MWF/Hsd mean arterial blood pressure sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. arterial blood pressure trait male 84 days 5 102.0 mmHg 3.0 6.71 vascular indwelling catheter method aorta 0.0 0 108773 3130
MWF/Hsd left ventricular end-diastolic blood pressure sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart left ventricular blood pressure trait male 84 days 5 6.2 mmHg 1.9 4.25 vascular indwelling catheter method heart left ventricle 0.0 0 108777 3130
HsdCpb:WU heart rate sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart pumping trait male 84 days 5 359.0 beats/min 18.0 40.25 vascular indwelling catheter method heart 0.0 0 108778 3130
MWF/Hsd central venous pressure sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. venous blood pressure trait male 84 days 5 2.1 mmHg 1.7 3.8 vascular indwelling catheter method vena cava 0.0 0 108781 3130
HsdCpb:WU maximum rate of positive change in left ventricular blood pressure sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart left ventricular blood pressure trait male 175 days 10 9091.0 mmHg/s 299.0 945.52 vascular indwelling catheter method heart left ventricle 0.0 0 108850 3130
MWF/Hsd maximum rate of positive change in left ventricular blood pressure left anterior descending coronary artery occlusion Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart left ventricular blood pressure trait male 175 days 10 8452.0 mmHg/s 455.0 1438.84 vascular indwelling catheter method heart left ventricle 0.0 0 108853 3130
HsdCpb:WU systemic vascular resistance left anterior descending coronary artery occlusion Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. arterial blood pressure trait male 168 days 6 0.95 mmHg/ml/min 0.1 0.24 vascular indwelling catheter method 0.0 0 108891 3130
HsdCpb:WU systemic vascular resistance left anterior descending coronary artery occlusion Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. arterial blood pressure trait male 168 days 10 1.04 mmHg/ml/min 0.18 0.57 vascular indwelling catheter method 0.0 0 108893 3130
HsdCpb:WU renal vascular resistance sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. arterial blood pressure trait male 175 days 10 13.2 mmHg/ml/min 1.9 6.01 vascular indwelling catheter method 0.0 0 108894 3130
MWF/Hsd renal vascular resistance left anterior descending coronary artery occlusion Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. arterial blood pressure trait male 175 days 10 39.5 mmHg/ml/min 6.9 21.82 vascular indwelling catheter method 0.0 0 108896 3130
HsdCpb:WU renal vascular resistance left anterior descending coronary artery occlusion Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. arterial blood pressure trait male 175 days 6 13.5 mmHg/ml/min 1.3 3.18 vascular indwelling catheter method 0.0 0 108897 3130
MWF/Hsd renal vascular resistance control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. arterial blood pressure trait male 84 days 5 47.0 mmHg/ml/min 12.0 26.83 vascular indwelling catheter method 0.0 0 108899 3130
HsdCpb:WU heart rate sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart pumping trait male 175 days 10 331.0 beats/min 14.0 44.27 vascular indwelling catheter method heart 0.0 0 108838 3130
HsdCpb:WU mean arterial blood pressure sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. arterial blood pressure trait male 175 days 10 94.0 mmHg 3.0 9.49 vascular indwelling catheter method aorta 0.0 0 108842 3130
MWF/Hsd mean arterial blood pressure sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. arterial blood pressure trait male 175 days 9 107.0 mmHg 4.0 12.0 vascular indwelling catheter method aorta 0.0 0 108844 3130
MWF/Hsd mean arterial blood pressure left anterior descending coronary artery occlusion Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. arterial blood pressure trait male 175 days 10 84.0 mmHg 5.0 15.81 vascular indwelling catheter method aorta 0.0 0 108845 3130
SR/Hsd range of heart rate variation during variation of mean arterial blood pressure artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. heart pumping trait male 52 days-61 days 6 211.0 beats/min 18.0 44.09 vascular indwelling catheter method 0.0 0 change in heart rate to change in mean arterial blood pressure ratio (range) (CMO:0003896) 138430 2801
SR/Hsd mean arterial pressure at the midpoint of a range of renal sympathetic nerve activity aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 8 109.0 mmHg 3.0 8.49 vascular indwelling catheter method 0.0 0 138428 2801
SS/Hsd heart rate artificial cerebrospinal fluid with 0.14 M sodium (4.4-4.6 ul/hr) (for 14 days) and aldosterone (22.5 ng/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. heart pumping trait male 49 days-57 days 0 465.0 beats/min 10.0 vascular indwelling catheter method 0.0 0 138451 2801
MWF mean arterial blood pressure cyclosporine A (50 mg/kg/d) (for 7 days) Fassi A, etal., Am J Kidney Dis. 1999 Feb;33(2):267-75. doi: 10.1016/s0272-6386(99)70299-4. arterial blood pressure trait male 133 days-147 days 6 110.0 mmHg 3.67 9.0 vascular indwelling catheter method femoral artery 0.0 0 110077 3163
SS/Hsd mean arterial blood pressure artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 0 108.0 mmHg 2.0 vascular indwelling catheter method 0.0 0 138368 2801
SS/Hsd percent change in heart rate artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) then air-jet exposure (1-1.5 lb/in2) (for 0 hours) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. heart pumping trait male 49 days-56 days 0 4.0 % 0.2 vascular indwelling catheter method 0.0 0 138370 2801
SR/Hsd mean arterial pressure at the midpoint of a range of heart rates aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 8 108.0 mmHg 3.0 8.49 vascular indwelling catheter method 0.0 0 138439 2801
SS/Hsd mean arterial blood pressure aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 0 131.0 mmHg 3.0 vascular indwelling catheter method 0.0 0 138447 2801
LH/Mav diastolic blood pressure control condition Dubay C, et al., Nat Genet 1993 Apr;3(4):354-7 arterial blood pressure trait male 203 days-217 days 16 serial mean 118.4 mmHg vascular indwelling catheter method abdominal aorta 10800 0 11647 111
BN.GH-(D6Mit12-D6Rat15)/Mcwi diastolic blood pressure control condition Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 127 days-143 days 16 serial mean 82.7 mmHg 3.0 12.0 vascular indwelling catheter method left femoral artery and vein 4 hrs/day for 3 days 0 microrenathane catheter; recover for 1 week after surgery 11537 101
BN/Elh change in heart rate to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart pumping trait male 132 days-146 days 14 -2.28 (beats/min)/(ug/kg) 0.07 0.26 vascular indwelling catheter method 0.0 0 ng/kg/min change in heart rate to change in vasoactive chemical dose ratio (CMO:0003904), (beats/min)/(ug/kg) 138470 101
BN/NHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 19 serial mean 22.0 mmHg 3.0 13.08 vascular indwelling catheter method left femoral artery 0.0 0 67301 151
BN.GH-(D18Rat41-D18Mgh4)/Mcwi change in heart rate to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart pumping trait male 132 days-146 days 11 -1.25 (beats/min)/(ug/kg) 0.05 0.17 vascular indwelling catheter method 0.0 0 ng/kg/min change in heart rate to change in vasoactive chemical dose ratio (CMO:0003904), (beats/min)/(ug/kg) 138469 101
BN/Elh mean arterial blood pressure control condition Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 127 days-143 days 21 serial mean 99.8 mmHg 2.18 10.0 vascular indwelling catheter method left femoral artery and vein 4 hrs/day for 3 days 0 microrenathane catheter; recover for 1 week after surgery 11549 101
MNS/Gib diastolic blood pressure control condition Zagato et al., 2000, Hypertension, 36(5), 734-9 arterial blood pressure trait not specified 112 days 15 continuous mean 96.9 mmHg 2.8 10.84 vascular indwelling catheter method carotid artery 1 min tracing every 3-4 min for 1 h 0 Gould BS3200 BP recorder 11724 122
MHS/Gib diastolic blood pressure control condition Zagato et al., 2000, Hypertension, 36(5), 734-9 arterial blood pressure trait not specified 112 days 22 continuous mean 113.4 mmHg 5.3 24.86 vascular indwelling catheter method carotid artery 1 min tracing every 3-4 min for 1 h 0 Gould BS3200 BP recorder 11727 122
WKHA/Cfd time constant of left ventricular pressure decay sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 13.3 ms 0.27 0.6 vascular indwelling catheter method 0.0 0 68916 1014
Crl:WI heart rate controlled NG-nitroarginine methyl ester content drinking water (20 mg/kg/d) (between 0 and 672 hours) Blanc J, et al., J Hypertens. 1999 Nov;17(11):1527-34. heart pumping trait male 0 days 15 378.0 beats/min 7.0 27.11 vascular indwelling catheter method 0.0 0 70419 1418
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd left ventricular end-systolic blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 128.6 mmHg 2.9 6.48 vascular indwelling catheter method 0.0 0 68873 1014
BN.GH-(D6Mit12-D6Rat15)/Mcwi change in mean arterial blood pressure to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 130 days-144 days 11 0.86 mmHg/ng/kg/min 0.02 0.08 vascular indwelling catheter method left femoral artery and vein 0.0 0 microrenathane catheter; recover for 1 week after surgery slope of map response curve 68341 101
WKHA/Cfd time constant of left ventricular pressure decay artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 21.7 ms 1.6 3.58 vascular indwelling catheter method 0.0 0 68923 1014
WKY/Izm heart rate control condition Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. heart pumping trait male 98 days 6 320.0 beats/min 11.0 26.94 vascular indwelling catheter method 0.0 0 84550 1120
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion then dihydrocapsaicin (0.3 mg/kg) (for 0.7 hours) and Capsazepine (3 mg/kg) (for 0.7 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 370.0 beats/min 11.0 26.94 vascular indwelling catheter method 0.0 0 104671 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then dihydrocapsaicin (1 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 385.0 beats/min 15.0 36.74 vascular indwelling catheter method 0.0 0 104696 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then dihydrocapsaicin (0.3 mg/kg) (for 0.9 hours) and Capsazepine (3 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 385.0 beats/min 10.0 24.49 vascular indwelling catheter method 0.0 0 104698 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then dihydrocapsaicin (0.3 mg/kg) (for 0.9 hours) and cyclosporine A (2.5 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 88.0 mmHg 5.0 12.25 vascular indwelling catheter method 0.0 0 104717 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then dihydrocapsaicin (0.3 mg/kg) (for 3.2 hours) and Capsazepine (3 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 74.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 104725 2988
MW mean arterial blood pressure nephrectomy (for 28 days) then enalapril (50 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. arterial blood pressure trait male 0 days 8 undefined 107.0 mmHg 2.0 5.66 vascular indwelling catheter method 0.0 5/6 nephrectomy 28 days 100996 2561
SR/Hsd heart rate aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. heart pumping trait male 49 days-57 days 0 451.0 beats/min 12.0 vascular indwelling catheter method 0.0 0 138375 2801
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure vehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 32.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84568 1120
WKY/Izm absolute change in mean arterial blood pressure vehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) then phenylephrine (3 ug) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 50.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84570 1120
WKY/Izm mean arterial blood pressure control condition Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 106.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 84546 1120
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure air-jet exposure (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 36.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84557 1120
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days-94 days 12 serial mean 160.0 mmHg 6.0 20.78 vascular indwelling catheter method left femoral artery 0 0 65463 151
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 93 days 14 serial mean 395.0 beats/min 7.0 26.19 vascular indwelling catheter method left femoral artery 0 0 65468 151
HTG mean arterial blood pressure losartan (10 mg/kg) (for 0.2 hours) Ueno T, et al., J Mol Med 2003 Jan;81(1):51-60. Epub 2002 Nov 21. arterial blood pressure trait both 151 days-181 days 19 continuous mean 115.0 mmHg 3.0 13.08 vascular indwelling catheter method carotid artery, jugular vein 1800 0 64702 249
WKY.SHR-(D1Rat56-D1M7Mit206)/Njs diastolic blood pressure control condition Frantz S, et al., Hypertension 2001 Aug;38(2):216-21 arterial blood pressure trait male 196 days 15 107.9 mmHg 2.69 10.4 vascular indwelling catheter method 0 beat to beat for 1 hour 11334 72
SHR.WKY-(D1Wox19-D1Wox34)/Njs diastolic blood pressure control condition Frantz S, et al., Hypertension 2001 Aug;38(2):216-21 arterial blood pressure trait male 196 days 20 137.3 mmHg 2.33 10.4 vascular indwelling catheter method 0 beat to beat for 1 hour 11337 72
BN.GH-(D2Rat22-D2Mgh11)/Mcwi mean arterial blood pressure control condition Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 127 days-143 days 19 serial mean 103.8 mmHg 2.11 9.2 vascular indwelling catheter method left femoral artery and vein 4 hrs/day for 3 days 0 microrenathane catheter; recover for 1 week after surgery 11528 101
BN/NHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 20 serial mean 27.0 mmHg 2.0 8.94 vascular indwelling catheter method left femoral artery 0.0 0 67299 151
F344/NHsd mean pulmonary arterial blood pressure air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 pulmonary arterial blood pressure trait male 105 days 23 median 27.0 mmHg vascular indwelling catheter method pulmonary artery 0 0 11566 102
SHR/Izm mean arterial blood pressure control condition Tsujita Y, et al., Am J Physiol Heart Circ Physiol 2000 Nov;279(5):H2062-7 arterial blood pressure trait male 168 days 6 continuous mean 174.0 mmHg 2.86 7.0 vascular indwelling catheter method 30 min between 2-5 pm 0 polyethylene catheter (PE-50) 11581 103
LN/Mav systolic blood pressure control condition Dubay C, et al., Nat Genet 1993 Apr;3(4):354-7 arterial blood pressure trait male 203 days-217 days 14 serial mean 136.4 mmHg vascular indwelling catheter method abdominal aorta 10800 0 11646 111
SHRSP/Bbb heart rate control condition Kreutz R, et al., Circulation 1997 Aug 19;96(4):1078-81. heart pumping trait male 112 days 12 serial mean 394.0 beats/min 7.22 25.0 vascular indwelling catheter method femoral artery 0 3 sets of readings per day for two days 13288 334
LN/MavRrrc absolute change in systolic blood pressure trimethaphan camsylate (10 mg/kg) (for 0.2 hours) Vincent M, et al., J Clin Invest 1997 Oct 15;100(8):2000-6 arterial blood pressure trait not specified 203 days-217 days 15 serial mean -56.5 mmHg 2.01 7.8 vascular indwelling catheter method abdominal aorta 3600 0 65263 121
SHR systolic blood pressure control condition Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 188.0 mmHg 2.0 9.59 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65347 306
SHR.BN-(D2Rat114-D2Rat123)/Jk diastolic blood pressure control condition Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 22 continuous mean 127.0 mmHg 2.0 9.38 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65352 306
SHR heart rate control condition (for 98 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. heart pumping trait male 87 days 23 continuous mean 365.0 beats/min 3.0 14.39 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65353 306
SHR.BN-(D16Rat87-D16Mgh1)/Jk systolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 178.5 mmHg 2.7 12.95 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 12753 306
WKY diastolic blood pressure control condition Frantz SA, et al., Hypertension 1998 Oct;32(4):639-46 arterial blood pressure trait male 175 days 24 continuous mean 102.1 mmHg 2.47 12.1 vascular indwelling catheter method aorta 0 11902 206
SHR systolic blood pressure control condition Frantz SA, et al., Hypertension 1998 Oct;32(4):639-46 arterial blood pressure trait male 175 days 28 continuous mean 232.2 mmHg 2.29 12.1 vascular indwelling catheter method aorta 0 11903 206
WKY/Gcrc systolic blood pressure control condition Graham D, et al., Hypertension. 2007 Dec; 50(6):1134-41. arterial blood pressure trait male 91 days-126 days 10 137.4 mmHg 2.17 6.86 vascular indwelling catheter method abdominal aorta 3024000 0 implanted at 84 days with 7 day recovery; Dataquest IV telemetry system (Data Sciences International) 12726 302
LEW diastolic blood pressure control condition Ueno T, et al., Physiol Genomics 2004 Mar 12;17(1):38-47. arterial blood pressure trait male 151 days-181 days 9 80.3 mmHg 2.9 8.7 vascular indwelling catheter method carotid artery and jugular vein 0 polyethylene catheter 11716 120
GH/Omr diastolic blood pressure control condition Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 127 days-143 days 21 serial mean 129.5 mmHg 3.27 15.0 vascular indwelling catheter method left femoral artery and vein 4 hrs/day for 3 days 0 microrenathane catheter; recover for 1 week after surgery 11523 101
LEW/CrlCrlj mean arterial blood pressure control condition Tsujita Y, et al., Am J Physiol Heart Circ Physiol 2000 Nov;279(5):H2062-7 arterial blood pressure trait male 168 days 5 continuous mean 112.0 mmHg 1.34 3.0 vascular indwelling catheter method 30 min between 2-5 pm 0 polyethylene catheter (PE-50) 11580 103
HTG diastolic blood pressure control condition Ueno T, et al., Physiol Genomics 2004 Mar 12;17(1):38-47. arterial blood pressure trait male 151 days-181 days 10 103.2 mmHg 3.2 10.12 vascular indwelling catheter method carotid artery and jugular vein 0 polyethylene catheter 11712 120
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89 days-92 days 21 serial mean 130.0 mmHg 4.0 18.33 vascular indwelling catheter method left femoral artery 0 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 11849 151
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89 days-92 days 21 serial mean 174.0 mmHg 6.0 27.5 vascular indwelling catheter method left femoral artery 0 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 11854 151
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91 days-94 days 35 continuous mean 167.0 mmHg 4.0 23.66 vascular indwelling catheter method femoral artery 259200.0 0 3 h per day 12002 229
LEW/Cub systolic blood pressure losartan (10 mg/kg) (for 0.2 hours) then pentolinium (5 mg/kg) (for 0.1 hours) then NG-nitroarginine methyl ester (30 mg/kg) (for 0.3 hours) Ueno T, et al., Physiol Res 2003;52(6):689-700. arterial blood pressure trait not specified 0 days 9 continuous mean 128.5 mmHg vascular indwelling catheter method 0 65383 568
SHR.BN-(D2Rat226-D2Rat294)/Jk systolic blood pressure control condition Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 22 continuous mean 168.0 mmHg 2.0 9.38 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65400 306
SHR.BN-(D2Rat226-D2Rat294)/Jk heart rate control condition (for 98 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. heart pumping trait male 87 days 22 continuous mean 340.0 beats/min 5.0 23.45 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65422 306
LN/MavRrrc absolute change in systolic blood pressure losartan (20 mg/kg) (for 0.7 hours) Vincent M, et al., J Clin Invest 1997 Oct 15;100(8):2000-6 arterial blood pressure trait not specified 203 days-217 days 15 serial mean -0.8 mmHg 1.32 5.13 vascular indwelling catheter method abdominal aorta 3600 0 65259 121
BN-Lx/Cub mean arterial blood pressure control condition Pravenec M, et al., J Hypertens 1989 Mar;7(3):217-21. arterial blood pressure trait male 0 days 8 113.0 mmHg 3.0 16.16 vascular indwelling catheter method carotid artery segment 0.0 0 66038 651
SHR/Ola mean arterial blood pressure control condition Pravenec M, et al., J Hypertens 1989 Mar;7(3):217-21. arterial blood pressure trait male 0 days 29 181.0 mmHg 4.0 11.31 vascular indwelling catheter method carotid artery segment 0.0 0 66039 651
F344/NHsd mean arterial blood pressure air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 arterial blood pressure trait male 105 days 23 median 112.0 mmHg vascular indwelling catheter method left common carotid artery 0 0 66128 102
WKY/Cfd left ventricular end-diastolic blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 1.34 mmHg 0.7 1.57 vascular indwelling catheter method 0.0 0 68809 1014
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (0.5 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 120.4 mmHg 5.3 24.29 vascular indwelling catheter method left femoral artery 120.0 0 69535 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 128.6 mmHg 4.0 18.33 vascular indwelling catheter method left femoral artery 120.0 0 69537 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 20 serial mean 135.6 mmHg 3.2 14.31 vascular indwelling catheter method left femoral artery 120.0 0 69539 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 9 serial mean 132.0 mmHg 7.0 21.0 vascular indwelling catheter method left femoral artery 120.0 0 69542 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 16 serial mean 118.6 mmHg 3.4 13.6 vascular indwelling catheter method left femoral artery 120.0 0 69543 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 9 serial mean 159.0 mmHg 7.1 21.3 vascular indwelling catheter method left femoral artery 120.0 0 69546 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 138.6 mmHg 3.8 17.41 vascular indwelling catheter method left femoral artery 120.0 0 69547 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 17 serial mean 144.9 mmHg 3.1 12.78 vascular indwelling catheter method left femoral artery 120.0 0 69549 151
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd time constant of left ventricular pressure decay artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 13.2 ms 1.8 4.02 vascular indwelling catheter method 0.0 0 68919 1014
WKY/Cfd time constant of left ventricular pressure decay artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 13.36 ms 1.4 3.13 vascular indwelling catheter method 0.0 0 68921 1014
WKHA/Cfd time constant of left ventricular pressure decay sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 13.5 ms 1.8 4.02 vascular indwelling catheter method 0.0 0 68922 1014
Crl:WI systolic blood pressure control condition Blanc J, et al., J Hypertens. 1999 Nov;17(11):1527-34. arterial blood pressure trait male 0 days 13 132.0 mmHg 4.0 14.42 vascular indwelling catheter method 0.0 0 70415 1418
WKY/Cfd maximum rate of positive change in left ventricular blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 9876.0 mmHg/s 495.0 1106.85 vascular indwelling catheter method 0.0 0 "rate of maximum positive change in left ventricular blood pressure" mmHg/s 68890 1014
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 94 days 17 serial mean 134.6 mmHg 4.1 16.9 vascular indwelling catheter method left femoral artery 10800.0 0 69521 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 94 days 17 serial mean 91.6 mmHg 3.6 14.84 vascular indwelling catheter method left femoral artery 10800.0 0 69523 151
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 94 days 16 serial mean 370.1 beats/min 6.3 25.2 vascular indwelling catheter method left femoral artery 10800.0 0 69525 151
Crl:WI heart rate control condition Blanc J, et al., J Hypertens. 1999 Nov;17(11):1527-34. heart pumping trait male 0 days 13 363.0 beats/min 8.0 28.84 vascular indwelling catheter method 0.0 0 70420 1418
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd left ventricular end-diastolic blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 0.33 mmHg 0.18 0.4 vascular indwelling catheter method 0.0 0 68860 1014
WKHA/Cfd left ventricular end-diastolic blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 1.99 mmHg 0.42 0.94 vascular indwelling catheter method 0.0 0 68857 1014
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd left ventricular end-systolic blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 139.9 mmHg 4.8 10.73 vascular indwelling catheter method 0.0 0 68865 1014
WKY/Cfd left ventricular end-systolic blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 119.6 mmHg 3.6 8.05 vascular indwelling catheter method 0.0 0 68868 1014
WKHA/Cfd left ventricular end-systolic blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 130.0 mmHg 5.5 12.3 vascular indwelling catheter method 0.0 0 68870 1014
WKHA/Cfd maximum rate of positive change in left ventricular blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 9127.0 mmHg/s 286.0 639.52 vascular indwelling catheter method 0.0 0 68892 1014
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd maximum rate of positive change in left ventricular blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 10888.0 mmHg/s 484.0 1082.26 vascular indwelling catheter method 0.0 0 68894 1014
WKY/Cfd maximum rate of negative change in left ventricular blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 6595.0 mmHg/s 297.0 664.11 vascular indwelling catheter method 0.0 0 68903 1014
WKY/Cfd maximum rate of negative change in left ventricular blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 6670.0 mmHg/s 179.0 400.26 vascular indwelling catheter method 0.0 0 68909 1014
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd maximum rate of negative change in left ventricular blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 6589.0 mmHg/s 296.0 661.88 vascular indwelling catheter method 0.0 0 68912 1014
WKY/NCrl diastolic blood pressure controlled sodium content diet (8 %) (for 14 days) then controlled exposure to ambient light (for 14 days) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 126 days 7 89.3 mmHg 0.76 2.0 vascular indwelling catheter method left common carotid artery 0.0 0 daytime (7 AM - 7 PM) 70087 1281
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89 days-91 days 20 serial mean 130.0 mmHg 3.5 15.65 vascular indwelling catheter method left femoral artery 0.0 0 69443 151
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89 days-91 days 15 serial mean 184.0 mmHg 7.7 29.82 vascular indwelling catheter method left femoral artery 0.0 0 69444 151
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89 days-91 days 15 serial mean 139.0 mmHg 6.0 23.24 vascular indwelling catheter method left femoral artery 0.0 0 69446 151
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 89 days-91 days 18 serial mean 386.0 beats/min 4.1 17.39 vascular indwelling catheter method left femoral artery 0.0 0 69449 151
FHH/EurMcwi mean arterial blood pressure control condition O'Meara CC, et al., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5. arterial blood pressure trait male 189 days 7 serial mean 123.0 mmHg 8.0 21.17 vascular indwelling catheter method femoral artery 10800.0 0 1day/week 96903 1738
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure candesartan (1 ug) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 -1.0 mmHg 4.0 9.8 vascular indwelling catheter method 0.0 0 84569 1120
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure candesartan (1 ug) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) then phenylephrine (3 ug) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 56.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84573 1120
MW mean arterial blood pressure doxorubicin (2 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 7 undefined 117.0 mmHg 4.0 10.58 vascular indwelling catheter method 0.0 doxorubicin 29 days 101175 2581
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion then dihydrocapsaicin (0.1 mg/kg) (for 0.7 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 128.0 mmHg 4.0 9.8 vascular indwelling catheter method 0.0 0 104676 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion then dihydrocapsaicin (0.3 mg/kg) (for 0.7 hours) and Capsazepine (3 mg/kg) (for 0.7 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 134.0 mmHg 4.0 9.8 vascular indwelling catheter method 0.0 0 104680 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion then dihydrocapsaicin (0.3 mg/kg) (for 0.7 hours) and cyclosporine A (2.5 mg/kg) (for 0.7 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 100.0 mmHg 4.0 9.8 vascular indwelling catheter method 0.0 0 104681 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion then cyclosporine A (2.5 mg/kg) (for 0.7 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 106.0 mmHg 5.0 12.25 vascular indwelling catheter method 0.0 0 104683 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 352.0 beats/min 4.0 9.8 vascular indwelling catheter method 0.0 0 104693 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then dihydrocapsaicin (0.3 mg/kg) (for 0.9 hours) and cyclosporine A (2.5 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 443.0 beats/min 5.0 12.25 vascular indwelling catheter method 0.0 0 104699 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then Capsazepine (3 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 5 356.0 beats/min 14.0 31.3 vascular indwelling catheter method 0.0 0 104700 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then dihydrocapsaicin (0.1 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 362.0 beats/min 6.0 14.7 vascular indwelling catheter method 0.0 0 104703 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then dihydrocapsaicin (0.3 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 89.0 mmHg 14.0 34.29 vascular indwelling catheter method 0.0 0 104713 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then dihydrocapsaicin (3 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 113.0 mmHg 5.0 12.25 vascular indwelling catheter method 0.0 0 104715 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then dihydrocapsaicin (0.1 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 86.0 mmHg 5.0 12.25 vascular indwelling catheter method 0.0 0 104721 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion then cyclosporine A (2.5 mg/kg) (for 0.7 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 413.0 beats/min 14.0 34.29 vascular indwelling catheter method 0.0 0 104750 2988
SD-Trpv1em1Sage-/- heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 423.0 beats/min 14.0 34.29 vascular indwelling catheter method 0.0 0 104751 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion then dihydrocapsaicin (0.3 mg/kg) (for 0.7 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 134.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 104754 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 385.0 beats/min 11.0 26.94 vascular indwelling catheter method 0.0 0 104771 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then dihydrocapsaicin (0.3 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 377.0 beats/min 11.0 26.94 vascular indwelling catheter method 0.0 0 104772 2988
SD-Trpv1em1Sage-/- heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 430.0 beats/min 12.0 29.39 vascular indwelling catheter method 0.0 0 104775 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then dihydrocapsaicin (0.3 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 118.0 mmHg 10.0 24.49 vascular indwelling catheter method 0.0 0 104778 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then cyclosporine A (2.5 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 75.0 mmHg 6.0 14.7 vascular indwelling catheter method 0.0 0 104780 2988
SD-Trpv1em1Sage-/- mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 82.0 mmHg 7.0 17.15 vascular indwelling catheter method 0.0 0 104805 2988
SS/NEisSlc systolic blood pressure controlled cilazapril content drinking water (12.5 ug/ml) (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. arterial blood pressure trait not specified 547 days 10 122.0 mmHg 4.0 12.65 vascular indwelling catheter method femoral artery 0.0 0 106789 2339
SS/NEisSlc systolic blood pressure vehicle control condition (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. arterial blood pressure trait not specified 547 days 10 137.0 mmHg 3.0 9.49 vascular indwelling catheter method femoral artery 0.0 0 106791 2339
SHRSP/A3NCrl mean arterial blood pressure control condition Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. arterial blood pressure trait male 82 days-89 days 9 serial mean 142.0 mmHg 4.0 12.0 vascular indwelling catheter method femoral artery 432000.0 0 10 seconds every 5 minutes for 24hr baseline standard diet group baseline and after treatment 107045 3073
SHRSP/A3NCrl mean arterial blood pressure controlled sodium chloride content drinking water (1 %) and controlled fat content diet (24.5 %) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. arterial blood pressure trait male 82 days-89 days 9 serial mean 140.0 mmHg 2.0 6.0 vascular indwelling catheter method femoral artery 432000.0 0 10 seconds every 5 minutes for 24hr baseline high salt high fat diet group baseline and after treatment 107046 3073
SHRSP/A3NCrl mean arterial blood pressure controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. arterial blood pressure trait male 99 days-141 days 9 serial mean 175.0 mmHg 1.0 3.0 vascular indwelling catheter method femoral artery 432000.0 0 10 seconds every 5 minutes for 24hr high salt high fat diet +8 wk treat group baseline and after treatment 107050 3073
HsdCpb:WU mean arterial blood pressure sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. arterial blood pressure trait male 84 days 5 89.0 mmHg 4.0 8.94 vascular indwelling catheter method aorta 0.0 0 108772 3130
HsdCpb:WU left ventricular systolic blood pressure sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart left ventricular blood pressure trait male 84 days 5 117.0 mmHg 5.0 11.18 vascular indwelling catheter method heart left ventricle 0.0 0 108774 3130
MWF/Hsd maximum rate of negative change in left ventricular blood pressure sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart left ventricular blood pressure trait male 175 days 9 6199.0 mmHg/s 513.0 1539.0 vascular indwelling catheter method heart left ventricle 0.0 0 108856 3130
MWF/Hsd maximum rate of negative change in left ventricular blood pressure left anterior descending coronary artery occlusion Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart left ventricular blood pressure trait male 175 days 10 4377.0 mmHg/s 299.0 945.52 vascular indwelling catheter method heart left ventricle 0.0 0 108857 3130
HsdCpb:WU renal vascular resistance control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. arterial blood pressure trait male 84 days 5 17.0 mmHg/ml/min 4.0 8.94 vascular indwelling catheter method 0.0 0 108898 3130
MWF/Hsd heart rate sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart pumping trait male 84 days 5 364.0 beats/min 14.0 31.3 vascular indwelling catheter method heart 0.0 0 108779 3130
MWF/Hsd left ventricular systolic blood pressure sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart left ventricular blood pressure trait male 84 days 5 131.0 mmHg 3.0 6.71 vascular indwelling catheter method heart left ventricle 0.0 0 108775 3130
HsdCpb:WU mean arterial blood pressure left anterior descending coronary artery occlusion Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. arterial blood pressure trait male 175 days 6 88.0 mmHg 4.0 9.8 vascular indwelling catheter method aorta 0.0 0 108843 3130
MWF mean arterial blood pressure controlled enalapril content drinking water (10 mg/kg) (for 28 days) Schie?l IM, etal., J Pharmacol Exp Ther. 2015 May;353(2):299-306. doi: 10.1124/jpet.114.222125. Epub 2015 Feb 13. arterial blood pressure trait male 364 days 6 110.9 mmHg 0.6 1.47 vascular indwelling catheter method right common carotid artery plus branches 0.0 0 108052 3113
SR/Hsd range of heart rate variation during variation of mean arterial blood pressure aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. heart pumping trait male 52 days-61 days 8 226.0 beats/min 17.0 48.08 vascular indwelling catheter method 0.0 0 change in heart rate to change in mean arterial blood pressure ratio (range) (CMO:0003896) 138431 2801
SS/Hsd mean arterial pressure at the midpoint of a range of renal sympathetic nerve activity aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 8 131.0 mmHg 4.0 11.31 vascular indwelling catheter method 0.0 0 138429 2801
MWF mean arterial blood pressure castor oil Fassi A, etal., Am J Kidney Dis. 1999 Feb;33(2):267-75. doi: 10.1016/s0272-6386(99)70299-4. arterial blood pressure trait male 133 days-147 days 7 122.0 mmHg 2.65 7.0 vascular indwelling catheter method femoral artery 0.0 0 110076 3163
MWF mean arterial blood pressure cyclosporine A (50 mg/kg/d) (for 7 days) and lacidipine (1 mg/kg/d) (for 7 days) Fassi A, etal., Am J Kidney Dis. 1999 Feb;33(2):267-75. doi: 10.1016/s0272-6386(99)70299-4. arterial blood pressure trait male 133 days-147 days 7 96.0 mmHg 2.65 7.0 vascular indwelling catheter method femoral artery 0.0 0 110078 3163
SS/Hsd heart rate aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. heart pumping trait male 49 days-57 days 0 490.0 beats/min 10.0 vascular indwelling catheter method 0.0 0 138450 2801
SS/Hsd percent change in heart rate aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) then air-jet exposure (1-1.5 lb/in2) (for 0 hours) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. heart pumping trait male 49 days-56 days 0 8.0 % 0.7 vascular indwelling catheter method 0.0 0 138371 2801
SS/Hsd heart rate aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. heart pumping trait male 49 days-57 days 0 499.0 beats/min 15.0 vascular indwelling catheter method 0.0 0 138377 2801
SR/Hsd mean arterial blood pressure aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 0 110.0 mmHg 2.0 vascular indwelling catheter method 0.0 0 138367 2801
SS/Hsd heart rate artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. heart pumping trait male 49 days-57 days 0 453.0 beats/min 13.0 vascular indwelling catheter method 0.0 0 138376 2801
SR/Hsd mean arterial pressure at the midpoint of a range of heart rates artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 6 106.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 138438 2801
SS/Hsd percent change in mean arterial blood pressure artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) then Guanabenz (50 ug) (between 0 and 0.3 hours) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 0 -10.0 % 1.0 vascular indwelling catheter method 0.0 0 138442 2801
SS/Hsd percent change in mean arterial blood pressure aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) then Guanabenz (50 ug) (between 0 and 0.3 hours) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 0 -18.0 % 2.0 vascular indwelling catheter method 0.0 0 138443 2801
BN/Elh diastolic blood pressure control condition Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 127 days-143 days 21 serial mean 85.3 mmHg 2.62 12.0 vascular indwelling catheter method left femoral artery and vein 4 hrs/day for 3 days 0 microrenathane catheter; recover for 1 week after surgery 11551 101
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 1.5 days) then controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 96 days 24 continuous mean 141.0 mmHg 5.0 24.49 vascular indwelling catheter method femoral artery 10800.0 0 left femoral artery 12038 229
LEW mean arterial blood pressure losartan (10 mg/kg) (for 0.2 hours) then pentolinium (5 mg/kg) (for 0.1 hours) then NG-nitroarginine methyl ester (30 mg/kg) (for 0.3 hours) Ueno T, et al., J Mol Med 2003 Jan;81(1):51-60. Epub 2002 Nov 21. arterial blood pressure trait both 151 days-181 days 21 continuous mean 123.0 mmHg 5.0 22.91 vascular indwelling catheter method carotid artery, jugular vein 1800 0 64706 249
Crl:WI diastolic blood pressure control condition Blanc J, et al., J Hypertens. 1999 Nov;17(11):1527-34. arterial blood pressure trait male 0 days 13 96.0 mmHg 3.0 10.82 vascular indwelling catheter method 0.0 0 70416 1418
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd maximum rate of negative change in left ventricular blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 7195.0 mmHg/s 480.0 1073.31 vascular indwelling catheter method 0.0 0 68913 1014
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 93 days 20 serial mean 369.9 beats/min 5.1 22.81 vascular indwelling catheter method left femoral artery 10800.0 0 69519 151
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (for 21 days) Mattson DL, et al., Am J Physiol Regul Integr Comp Physiol. 2013 Jan 30. arterial blood pressure trait not specified 84 days 4 181.0 mmHg 9.0 18.0 vascular indwelling catheter method 0.0 0 69292 1057
WKY/NCrl systolic blood pressure controlled sodium content diet (8 %) (for 14 days) then controlled exposure to ambient light (for 14 days) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 126 days 7 126.4 mmHg 1.06 2.8 vascular indwelling catheter method left common carotid artery 0.0 0 daytime (7 AM - 7 PM) 70085 1281
WKY/NCrl diastolic blood pressure controlled sodium content diet (8 %) (for 14 days) then controlled exposure to darkness (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 126 days 7 93.9 mmHg 1.29 3.4 vascular indwelling catheter method left common carotid artery 0.0 0 nighttime (7 PM - 7 AM) 70088 1281
WKY/Cfd left ventricular end-diastolic blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 1.32 mmHg 0.3 0.67 vascular indwelling catheter method 0.0 0 68802 1014
WKHA/Cfd left ventricular end-diastolic blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 0.28 mmHg 0.37 0.83 vascular indwelling catheter method 0.0 0 68805 1014
WKY/Cfd left ventricular end-diastolic blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 1.66 mmHg 0.62 1.39 vascular indwelling catheter method 0.0 0 68808 1014
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure air-jet exposure (for 0 hours) then hexamethonium (40 mg/kg) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 -48.0 mmHg 6.0 14.7 vascular indwelling catheter method 0.0 0 69090 1120
WKY/Izm heart rate control condition Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. heart pumping trait male 98 days 6 317.0 beats/min 14.0 34.29 vascular indwelling catheter method 0.0 0 69086 1120
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then cyclosporine A (2.5 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 78.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 104728 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion then Capsazepine (3 mg/kg) (for 0.7 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 5 129.0 mmHg 6.0 13.42 vascular indwelling catheter method 0.0 0 104682 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then dihydrocapsaicin (0.3 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 368.0 beats/min 6.0 14.7 vascular indwelling catheter method 0.0 0 104704 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then dihydrocapsaicin (1 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 104.0 mmHg 10.0 24.49 vascular indwelling catheter method 0.0 0 104714 2988
MW mean arterial blood pressure control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 18 undefined 106.0 mmHg 3.0 12.73 vascular indwelling catheter method 0.0 control 29 days 101176 2581
WKY/Izm absolute change in heart rate air-jet exposure (for 0 hours) then vehicle control condition (2 ul) (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. heart pumping trait male 98 days 6 0.0 beats/min 6.0 14.7 vascular indwelling catheter method 0.0 0 84562 1120
SHR.BN-(D2Rat114-D2Rat123)/Jk diastolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 133.0 mmHg 2.0 9.59 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65343 306
SHR.BN-(D2Rat114-D2Rat123)/Jk mean arterial blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 156.0 mmHg 3.0 14.39 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65344 306
SHR heart rate controlled sodium content diet (1 %) (for 14 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. heart pumping trait male 87 days 24 continuous mean 380.0 beats/min 8.0 39.19 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65346 306
SHR mean arterial blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 24 continuous mean 170.0 mmHg 3.0 14.7 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65348 306
SHR mean arterial blood pressure control condition Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 162.0 mmHg 2.0 9.59 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65350 306
F344/NHsd mean pulmonary arterial blood pressure control condition Zhao L et al., 2001, Circulation, 103(3), 442-7 pulmonary arterial blood pressure trait male 105 days 12 median 16.0 mmHg vascular indwelling catheter method pulmonary artery 0 0 66123 102
SS/JrHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 34.0 mmHg 3.0 10.82 vascular indwelling catheter method left femoral artery 0.0 0 67300 151
SHR/NCruk systolic blood pressure control condition Frantz S, et al., Hypertension 2001 Aug;38(2):216-21 arterial blood pressure trait male 196 days 15 205.3 mmHg 3.3 12.8 vascular indwelling catheter method 0 beat to beat for 1 hour 11328 72
LH/Mav systolic blood pressure control condition Dubay C, et al., Nat Genet 1993 Apr;3(4):354-7 arterial blood pressure trait male 203 days-217 days 16 serial mean 174.1 mmHg vascular indwelling catheter method abdominal aorta 10800 0 11645 111
WKY.SHR-(D1Rat236-D1M7Mit206)/Njs diastolic blood pressure control condition Frantz S, et al., Hypertension 2001 Aug;38(2):216-21 arterial blood pressure trait male 196 days 15 114.3 mmHg 2.07 8.0 vascular indwelling catheter method 0 beat to beat for 1 hour 11335 72
LH/MavRrrc absolute change in systolic blood pressure trimethaphan camsylate (10 mg/kg) (for 0.2 hours) Vincent M, et al., J Clin Invest 1997 Oct 15;100(8):2000-6 arterial blood pressure trait not specified 203 days-217 days 16 serial mean -63.0 mmHg 2.17 8.7 vascular indwelling catheter method abdominal aorta 3600 0 65264 121
LH/MavRrrc absolute change in diastolic blood pressure darodipine (200 ug/kg) (for 0.2 hours) Vincent M, et al., J Clin Invest 1997 Oct 15;100(8):2000-6 arterial blood pressure trait not specified 203 days-217 days 16 serial mean -70.4 mmHg 1.93 7.7 vascular indwelling catheter method abdominal aorta 3600 0 65270 121
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) then controlled exposure to ambient light (for 12 hours) then controlled exposure to darkness (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91 days-93 days 42 continuous mean 4.5 mmHg 2.0 12.96 vascular indwelling catheter method femoral artery 0.0 0 left femoral artery increase 64928 229
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) then tactile electric shock exposure (2 %) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days-94 days 8 serial mean 11.0 mmHg 3.0 8.49 vascular indwelling catheter method left femoral artery 0 0 66150 151
LEW mean arterial blood pressure losartan (10 mg/kg) (for 0.2 hours) Ueno T, et al., J Mol Med 2003 Jan;81(1):51-60. Epub 2002 Nov 21. arterial blood pressure trait both 151 days-181 days 21 continuous mean 102.0 mmHg 2.0 9.17 vascular indwelling catheter method carotid artery, jugular vein 1800 0 12393 249
MNS/Gib systolic blood pressure control condition Zagato et al., 2000, Hypertension, 36(5), 734-9 arterial blood pressure trait not specified 112 days 14 continuous mean 138.3 mmHg 2.8 10.48 vascular indwelling catheter method carotid artery 1 min tracing every 3-4 min for 1 h 0 Gould BS3200 BP recorder 11723 122
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89 days-92 days 21 serial mean 92.0 mmHg 3.0 13.75 vascular indwelling catheter method left femoral artery 0 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 11851 151
BN.GH-(D18Rat41-D18Mgh4)/Mcwi heart rate control condition Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart pumping trait male 127 days-143 days 21 serial mean 361.7 beats/min 7.2 33.0 vascular indwelling catheter method left femoral artery and vein 4 hrs/day for 3 days 0 microrenathane catheter; recover for 1 week after surgery 11545 101
GH/Omr systolic blood pressure control condition Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 127 days-143 days 21 serial mean 190.9 mmHg 2.12 9.7 vascular indwelling catheter method left femoral artery and vein 4 hrs/day for 3 days 0 microrenathane catheter; recover for 1 week after surgery 11522 101
BN/Elh systolic blood pressure control condition Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 127 days-143 days 21 serial mean 116.4 mmHg 1.7 7.8 vascular indwelling catheter method left femoral artery and vein 4 hrs/day for 3 days 0 microrenathane catheter; recover for 1 week after surgery 11550 101
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91 days-94 days 42 continuous mean 127.0 mmHg 3.0 19.44 vascular indwelling catheter method femoral artery 259200.0 0 3 h per day 12006 229
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 84 days 28 continuous mean 125.0 mmHg 3.0 15.87 vascular indwelling catheter method femoral artery 3.0 0 left femoral artery 12024 229
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 1.5 days) then controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 96 days 21 continuous mean 96.0 mmHg 3.0 13.75 vascular indwelling catheter method femoral artery 10800.0 0 left femoral artery 13275 229
SHRSP/Bbb heart rate control condition Kreutz R, et al., Circulation 1997 Aug 19;96(4):1078-81. heart pumping trait female 112 days 11 serial mean 416.0 beats/min 9.65 32.0 vascular indwelling catheter method femoral artery 0 3 sets of readings per day for two days 13289 334
SHRSP/Bbb heart rate controlled sodium content drinking water (1 %) (between 13 and 15 days) Kreutz R, et al., Circulation 1997 Aug 19;96(4):1078-81. heart pumping trait male 125 days-127 days 12 serial mean 433.0 beats/min 4.33 15.0 vascular indwelling catheter method femoral artery 0 3 sets of readings per day for two days 13290 334
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 89 days-92 days 20 serial mean 367.0 beats/min 5.0 22.36 vascular indwelling catheter method left femoral artery 0 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 13309 151
SHR.BN-(D2Rat226-D2Rat294)/Jk mean arterial blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 22 continuous mean 154.0 mmHg 2.0 9.38 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65403 306
SHR.BN-(D4Rat33-D4Rat54)/Jk mean arterial blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 162.0 mmHg 2.0 9.59 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65409 306
SHR.BN-(D16Rat87-D16Mgh1)/Jk systolic blood pressure control condition Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 22 continuous mean 181.0 mmHg 2.0 9.38 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65411 306
WKY/NCruk mean pulmonary arterial blood pressure air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 pulmonary arterial blood pressure trait male 105 days 28 median 38.0 mmHg vascular indwelling catheter method pulmonary artery 0 0 66126 102
BN.GH-(D18Rat41-D18Mgh4)/Mcwi change in mean arterial blood pressure to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 130 days-144 days 11 0.71 mmHg/ng/kg/min 0.02 0.07 vascular indwelling catheter method left femoral artery and vein 0.0 0 microrenathane catheter; recover for 1 week after surgery slope of map response curve 68342 101
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd left ventricular end-diastolic blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 0.33 mmHg 0.32 0.72 vascular indwelling catheter method 0.0 0 68807 1014
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm heart rate control condition Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. heart pumping trait male 98 days 6 321.0 beats/min 11.0 26.94 vascular indwelling catheter method 0.0 0 69087 1120
SHRSP/Izm absolute change in mean arterial blood pressure air-jet exposure (for 0 hours) then hexamethonium (40 mg/kg) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 -102.0 mmHg 5.0 12.25 vascular indwelling catheter method 0.0 0 69091 1120
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 160.2 mmHg 3.5 12.62 vascular indwelling catheter method left femoral artery 120.0 0 69534 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 111.3 mmHg 4.6 21.08 vascular indwelling catheter method left femoral artery 120.0 0 69541 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 9 serial mean 159.1 mmHg 6.4 19.2 vascular indwelling catheter method left femoral artery 120.0 0 69550 151
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days 20 serial mean 140.6 mmHg 4.4 19.68 vascular indwelling catheter method left femoral artery 10800.0 0 69509 151
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 93 days 21 serial mean 127.2 mmHg 4.1 18.79 vascular indwelling catheter method left femoral artery 10800.0 0 69515 151
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 94 days 10 serial mean 411.7 beats/min 10.6 33.52 vascular indwelling catheter method left femoral artery 10800.0 0 69526 151
WKHA/Cfd left ventricular end-diastolic blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 0.62 mmHg 0.73 1.63 vascular indwelling catheter method 0.0 0 68858 1014
WKHA/Cfd left ventricular end-systolic blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 126.0 mmHg 5.17 11.56 vascular indwelling catheter method 0.0 0 68863 1014
WKY/Cfd left ventricular end-systolic blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 129.7 mmHg 0.8 1.79 vascular indwelling catheter method 0.0 0 68867 1014
WKHA/Cfd maximum rate of positive change in left ventricular blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 9597.0 mmHg/s 465.0 1039.77 vascular indwelling catheter method 0.0 0 68893 1014
WKY/Cfd maximum rate of positive change in left ventricular blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 10672.0 mmHg/s 343.0 766.97 vascular indwelling catheter method 0.0 0 68896 1014
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd maximum rate of positive change in left ventricular blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 9982.0 mmHg/s 250.0 559.02 vascular indwelling catheter method 0.0 0 68901 1014
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd maximum rate of negative change in left ventricular blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 7490.0 mmHg/s 227.0 507.59 vascular indwelling catheter method 0.0 0 68907 1014
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89 days-91 days 20 serial mean 111.0 mmHg 2.7 12.07 vascular indwelling catheter method left femoral artery 0.0 0 69447 151
WKY/NCrl diastolic blood pressure controlled exposure to darkness (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 112 days 7 92.5 mmHg 1.59 4.2 vascular indwelling catheter method left common carotid artery 0.0 0 nighttime (7 PM - 7 AM) 70084 1281
WKY/NCrl systolic blood pressure controlled sodium content diet (8 %) (for 14 days) then controlled exposure to darkness (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 126 days 7 131.7 mmHg 0.83 2.2 vascular indwelling catheter method left common carotid artery 0.0 0 nighttime (7 PM - 7 AM) 70086 1281
WKY.SHR-(D1Mgh14-D1Rat77)/Iwai diastolic blood pressure controlled exposure to darkness (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 112 days 8 94.6 mmHg 0.99 2.8 vascular indwelling catheter method left common carotid artery 0.0 0 nighttime (7 PM - 7 AM) 70092 1281
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure air-jet exposure (for 0 hours) then candesartan (1 ug) (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 -10.0 mmHg 1.0 2.45 vascular indwelling catheter method 0.0 0 85199 1120
FHH.PCK-(D9Rat35-D9Rat70)/Mcwi mean arterial blood pressure control condition O'Meara CC, et al., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5. arterial blood pressure trait male 189 days 8 serial mean 124.0 mmHg 4.0 11.31 vascular indwelling catheter method femoral artery 10800.0 0 1day/week 96902 1738
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm percent change in mean arterial blood pressure air-jet exposure (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 33.0 % 3.0 7.35 vascular indwelling catheter method 0.0 0 84543 1120
WKY/Izm absolute change in mean arterial blood pressure air-jet exposure (for 0 hours) then vehicle control condition (2 ul) (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 -3.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84553 1120
WKY/Izm absolute change in heart rate air-jet exposure (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. heart pumping trait male 98 days 6 85.0 beats/min 8.0 19.6 vascular indwelling catheter method 0.0 0 84558 1120
SR/JrIpcv systolic blood pressure controlled sodium content diet (0.3 %) Hojn¿ S, et al., Physiol Res. 2005;54(2):201-6. arterial blood pressure trait male 0 days 0 undefined 137.0 mmHg 3.0 vascular indwelling catheter method 0.0 0 102395 2688
SS/JrIpcv mean arterial blood pressure controlled sodium content diet (0.3 %) Hojn¿ S, et al., Physiol Res. 2005;54(2):201-6. arterial blood pressure trait male 0 days 0 undefined 131.0 mmHg 3.0 vascular indwelling catheter method 0.0 0 102398 2688
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion then dihydrocapsaicin (0.1 mg/kg) (for 0.7 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 377.0 beats/min 13.0 31.84 vascular indwelling catheter method 0.0 0 104667 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 109.0 mmHg 4.0 9.8 vascular indwelling catheter method 0.0 0 104711 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then dihydrocapsaicin (3 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 72.0 mmHg 4.0 9.8 vascular indwelling catheter method 0.0 0 104724 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 371.0 beats/min 10.0 24.49 vascular indwelling catheter method 0.0 0 104747 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion then dihydrocapsaicin (0.3 mg/kg) (for 0.7 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 370.0 beats/min 6.0 14.7 vascular indwelling catheter method 0.0 0 104748 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion then V1-Cal (1 mg/kg) (for 0.7 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 428.0 beats/min 6.0 14.7 vascular indwelling catheter method 0.0 0 104749 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion then cyclosporine A (2.5 mg/kg) (for 0.7 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 99.0 mmHg 6.0 14.7 vascular indwelling catheter method 0.0 0 104756 2988
SD-Trpv1em1Sage-/- mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion then V1-Cal (1 mg/kg) (for 0.7 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 123.0 mmHg 6.0 14.7 vascular indwelling catheter method 0.0 0 104758 2988
SD-Trpv1em1Sage-/- mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 104.0 mmHg 10.0 24.49 vascular indwelling catheter method 0.0 0 104781 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then cyclosporine A (2.5 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 68.0 mmHg 5.0 12.25 vascular indwelling catheter method 0.0 0 104804 2988
SS/NEisSlc systolic blood pressure controlled cilazapril content drinking water (2.5 ug/ml) (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. arterial blood pressure trait not specified 547 days 10 136.0 mmHg 3.0 9.49 vascular indwelling catheter method femoral artery 0.0 0 106788 2339
SS/NEisSlc systolic blood pressure controlled E4177 content drinking water (25 ug/ml) (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. arterial blood pressure trait not specified 547 days 10 132.0 mmHg 3.0 9.49 vascular indwelling catheter method femoral artery 0.0 0 106790 2339
SHRSP/A3NCrl mean arterial blood pressure control condition Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. arterial blood pressure trait male 99 days-141 days 9 serial mean 153.0 mmHg 2.0 6.0 vascular indwelling catheter method femoral artery 432000.0 0 10 seconds every 5 minutes for 24hr 8 weeks baseline and after treatment 107047 3073
SHRSP/A3NCrl mean arterial blood pressure controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 49 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. arterial blood pressure trait male 99 days-141 days 9 serial mean 183.0 mmHg 7.0 21.0 vascular indwelling catheter method femoral artery 432000.0 0 10 seconds every 5 minutes for 24hr high salt high fat diet +8 wk treat group baseline and after treatment 107049 3073
HsdCpb:WU central venous pressure sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. venous blood pressure trait male 84 days 5 1.2 mmHg 1.9 4.25 vascular indwelling catheter method vena cava 0.0 0 108780 3130
MWF/Hsd maximum rate of positive change in left ventricular blood pressure sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart left ventricular blood pressure trait male 175 days 9 8993.0 mmHg/s 318.0 954.0 vascular indwelling catheter method heart left ventricle 0.0 0 108852 3130
HsdCpb:WU maximum rate of negative change in left ventricular blood pressure left anterior descending coronary artery occlusion Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart left ventricular blood pressure trait male 175 days 6 6009.0 mmHg/s 432.0 1058.18 vascular indwelling catheter method heart left ventricle 0.0 0 108855 3130
MWF/Hsd heart rate sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart pumping trait male 175 days 9 364.0 beats/min 28.0 84.0 vascular indwelling catheter method heart 0.0 0 108840 3130
MWF/Hsd heart rate left anterior descending coronary artery occlusion Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart pumping trait male 175 days 10 416.0 beats/min 38.0 120.17 vascular indwelling catheter method heart 0.0 0 108841 3130
HsdCpb:WU left ventricular systolic blood pressure left anterior descending coronary artery occlusion Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart left ventricular blood pressure trait male 175 days 6 123.0 mmHg 8.0 19.6 vascular indwelling catheter method heart left ventricle 0.0 0 108847 3130
MWF/Hsd left ventricular systolic blood pressure sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart left ventricular blood pressure trait male 175 days 9 134.0 mmHg 3.0 9.0 vascular indwelling catheter method heart left ventricle 0.0 0 108848 3130
MWF/Hsd left ventricular systolic blood pressure left anterior descending coronary artery occlusion Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart left ventricular blood pressure trait male 175 days 10 108.0 mmHg 2.0 6.32 vascular indwelling catheter method heart left ventricle 0.0 0 108849 3130
MHS mean arterial blood pressure control condition Capasso G, etal., Am J Physiol Renal Physiol. 2008 Aug;295(2):F556-67. doi: 10.1152/ajprenal.00340.2007. Epub 2008 May 14. arterial blood pressure trait not specified 85 days-87 days 11 167.0 mmHg 1.7 5.64 vascular indwelling catheter method right internal carotid artery 0.0 0 110141 3164
MWF mean arterial blood pressure control condition Schie?l IM, etal., J Pharmacol Exp Ther. 2015 May;353(2):299-306. doi: 10.1124/jpet.114.222125. Epub 2015 Feb 13. arterial blood pressure trait male 364 days 5 144.6 mmHg 6.5 14.53 vascular indwelling catheter method right common carotid artery plus branches 0.0 0 108053 3113
SS/Hsd range of heart rate variation during variation of mean arterial blood pressure aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. heart pumping trait male 52 days-61 days 8 170.0 beats/min 12.0 33.94 vascular indwelling catheter method 0.0 0 change in heart rate to change in mean arterial blood pressure ratio (range) (CMO:0003896) 138433 2801
SR/Hsd change in heart rate to change in mean arterial blood pressure ratio artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. heart pumping trait male 52 days-61 days 6 -2.13 beats/min/mmHg 0.19 0.47 vascular indwelling catheter method 0.0 0 change in heart rate to cchange in heart rate to change in mean arterial blood pressure ratio (CMO:0002036) 138434 2801
SS/Hsd mean arterial pressure at the midpoint of a range of renal sympathetic nerve activity artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 7 110.0 mmHg 3.0 7.94 vascular indwelling catheter method 0.0 0 138427 2801
SS/Hsd mean arterial blood pressure aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 0 125.0 mmHg 2.0 vascular indwelling catheter method 0.0 0 138382 2801
SR/Hsd mean arterial blood pressure aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 0 105.0 mmHg 3.0 vascular indwelling catheter method 0.0 0 138379 2801
SS/Hsd mean arterial blood pressure aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 0 131.0 mmHg 3.0 vascular indwelling catheter method 0.0 0 138369 2801
SS/Hsd mean arterial pressure at the midpoint of a range of heart rates aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 8 132.0 mmHg 3.0 8.49 vascular indwelling catheter method 0.0 0 138441 2801
WKY systolic blood pressure control condition Frantz SA, et al., Hypertension 1998 Oct;32(4):639-46 arterial blood pressure trait male 175 days 24 continuous mean 167.3 mmHg 2.37 11.6 vascular indwelling catheter method aorta 0 11901 206
HTG diastolic blood pressure control condition Ueno T, et al., Physiol Genomics 2004 Mar 12;17(1):38-47. arterial blood pressure trait female 151 days-181 days 10 91.8 mmHg 2.8 8.85 vascular indwelling catheter method carotid artery and jugular vein 0 polyethylene catheter 11714 120
LEW diastolic blood pressure control condition Ueno T, et al., Physiol Genomics 2004 Mar 12;17(1):38-47. arterial blood pressure trait female 151 days-181 days 12 89.0 mmHg 2.5 8.66 vascular indwelling catheter method carotid artery and jugular vein 0 polyethylene catheter 11718 120
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 92 days 21 serial mean 386.5 beats/min 9.6 43.99 vascular indwelling catheter method left femoral artery 10800.0 0 69513 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89 days-91 days 20 serial mean 96.0 mmHg 2.7 12.07 vascular indwelling catheter method left femoral artery 0.0 0 69445 151
WKY/Izm mean arterial blood pressure control condition Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 108.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 69083 1120
LH/MavRrrc absolute change in diastolic blood pressure losartan (20 mg/kg) (for 0.7 hours) Vincent M, et al., J Clin Invest 1997 Oct 15;100(8):2000-6 arterial blood pressure trait not specified 203 days-217 days 16 serial mean -5.38 mmHg 1.54 6.17 vascular indwelling catheter method abdominal aorta 3600 0 65262 121
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then dihydrocapsaicin (3 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 370.0 beats/min 4.0 9.8 vascular indwelling catheter method 0.0 0 104706 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then Capsazepine (3 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 5 356.0 beats/min 7.0 15.65 vascular indwelling catheter method 0.0 0 104709 2988
SR/Hsd heart rate artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. heart pumping trait male 49 days-56 days 0 437.0 beats/min 10.0 vascular indwelling catheter method 0.0 0 138354 2801
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm mean arterial blood pressure control condition Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 103.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84551 1120
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure air-jet exposure (for 0 hours) then candesartan (1 ug) (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 -2.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 84554 1120
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm heart rate control condition Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. heart pumping trait male 98 days 6 326.0 beats/min 12.0 29.39 vascular indwelling catheter method 0.0 0 84560 1120
MW mean arterial blood pressure unilateral nephrectomy (for 70 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 6 undefined 105.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 unx 70 days 101172 2581
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days-94 days 12 serial mean 126.0 mmHg 5.0 17.32 vascular indwelling catheter method left femoral artery 0 0 65465 151
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days-94 days 14 serial mean 89.0 mmHg 2.0 7.48 vascular indwelling catheter method left femoral artery 0 0 65466 151
SHR.BN-(D2Rat114-D2Rat123)/Jk systolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 23 continuous mean 179.3 mmHg 3.5 16.79 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 12750 306
WKY/Gcrc systolic blood pressure controlled sodium content drinking water (1 %) (for 21 days) Graham D, et al., Hypertension. 2007 Dec; 50(6):1134-41. arterial blood pressure trait male 126 days-147 days 10 146.4 mmHg 2.53 8.0 vascular indwelling catheter method abdominal aorta 1814400 0 implanted at 84 days with 7 day recovery; Dataquest IV telemetry system (Data Sciences International) averaged over 21 days 12727 302
BN.GH-(D18Rat41-D18Mgh4)/Mcwi systolic blood pressure control condition Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 127 days-143 days 21 serial mean 116.7 mmHg 1.51 6.9 vascular indwelling catheter method left femoral artery and vein 4 hrs/day for 3 days 0 microrenathane catheter; recover for 1 week after surgery 11543 101
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91 days-94 days 35 continuous mean 206.0 mmHg 6.0 35.5 vascular indwelling catheter method femoral artery 259200.0 0 3 h per day 11984 229
LH/MavRrrc systolic blood pressure control condition Vincent M, et al., J Clin Invest 1997 Oct 15;100(8):2000-6 arterial blood pressure trait not specified 203 days-217 days 17 serial mean 173.0 mmHg 2.18 9.0 vascular indwelling catheter method abdominal aorta 3600 0 11720 121
MHS/Gib systolic blood pressure control condition Zagato et al., 2000, Hypertension, 36(5), 734-9 arterial blood pressure trait not specified 112 days 22 continuous mean 163.7 mmHg 1.9 8.91 vascular indwelling catheter method carotid artery 1 min tracing every 3-4 min for 1 h 0 Gould BS3200 BP recorder 11726 122
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89 days-92 days 21 serial mean 154.0 mmHg 6.0 27.5 vascular indwelling catheter method left femoral artery 0 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 11852 151
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91 days-94 days 35 continuous mean 185.0 mmHg 5.0 29.58 vascular indwelling catheter method femoral artery 259200.0 0 3 h per day 12004 229
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) and controlled exposure to darkness (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91 days-93 days 35 continuous mean 172.0 mmHg 7.0 41.41 vascular indwelling catheter method femoral artery 14400.0 0 left femoral artery 12005 229
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91 days-94 days 42 continuous mean 94.0 mmHg 2.0 12.96 vascular indwelling catheter method femoral artery 259200.0 0 3 h per day 12009 229
LH/MavRrrc absolute change in systolic blood pressure darodipine (200 ug/kg) (for 0.2 hours) Vincent M, et al., J Clin Invest 1997 Oct 15;100(8):2000-6 arterial blood pressure trait not specified 203 days-217 days 16 serial mean -97.8 mmHg 2.7 10.8 vascular indwelling catheter method abdominal aorta 3600 0 65268 121
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91 days-93 days 42 continuous mean 109.0 mmHg 3.0 19.44 vascular indwelling catheter method femoral artery 259200.0 0 3 h per day increase 66139 229
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) then tactile electric shock exposure (2 %) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days-94 days 14 serial mean 16.0 mmHg 3.0 11.22 vascular indwelling catheter method left femoral artery 0 0 66149 151
BN systolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 64 continuous mean 134.4 mmHg 8.7 69.6 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65342 306
SHR.WKY-(D1Wox19-D1Wox34)/Njs systolic blood pressure control condition Frantz S, et al., Hypertension 2001 Aug;38(2):216-21 arterial blood pressure trait male 196 days 20 187.5 mmHg 2.73 12.2 vascular indwelling catheter method 0 beat to beat for 1 hour 11329 72
WKY/NCruk diastolic blood pressure control condition Frantz S, et al., Hypertension 2001 Aug;38(2):216-21 arterial blood pressure trait male 196 days 19 95.8 mmHg 2.2 9.6 vascular indwelling catheter method 0 beat to beat for 1 hour 11332 72
WKY.SHR-(D1Wox19-D1Mit2)/Njs diastolic blood pressure control condition Frantz S, et al., Hypertension 2001 Aug;38(2):216-21 arterial blood pressure trait male 196 days 20 116.3 mmHg 2.24 10.0 vascular indwelling catheter method 0 beat to beat for 1 hour 11333 72
SHR/NCruk diastolic blood pressure control condition Frantz S, et al., Hypertension 2001 Aug;38(2):216-21 arterial blood pressure trait male 196 days 15 147.8 mmHg 3.18 12.3 vascular indwelling catheter method 0 beat to beat for 1 hour 11336 72
WKY/Bbb heart rate control condition Kreutz R, et al., Circulation 1997 Aug 19;96(4):1078-81. heart pumping trait male 112 days 12 serial mean 343.0 beats/min 10.1 35.0 vascular indwelling catheter method femoral artery 0 3 sets of readings per day for two days 13279 334
WKY/Bbb heart rate controlled sodium content drinking water (1 %) (between 13 and 15 days) Kreutz R, et al., Circulation 1997 Aug 19;96(4):1078-81. heart pumping trait male 125 days-127 days 11 serial mean 349.0 beats/min 12.06 40.0 vascular indwelling catheter method femoral artery 0 3 sets of readings per day for two days 13286 334
SHRSP/Bbb heart rate controlled sodium content drinking water (1 %) (between 13 and 15 days) Kreutz R, et al., Circulation 1997 Aug 19;96(4):1078-81. heart pumping trait female 125 days-127 days 10 serial mean 442.0 beats/min 9.17 29.0 vascular indwelling catheter method femoral artery 0 3 sets of readings per day for two days 13291 334
LEW/Cub diastolic blood pressure losartan (10 mg/kg) (for 0.2 hours) then pentolinium (5 mg/kg) (for 0.1 hours) then NG-nitroarginine methyl ester (30 mg/kg) (for 0.3 hours) Ueno T, et al., Physiol Res 2003;52(6):689-700. arterial blood pressure trait not specified 0 days 9 continuous mean 82.5 mmHg vascular indwelling catheter method 0 65392 568
SHR.BN-(D2Rat114-D2Rat123)/Jk systolic blood pressure control condition Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 22 continuous mean 175.0 mmHg 2.0 9.38 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65393 306
SHR.BN-(D2Rat114-D2Rat123)/Jk mean arterial blood pressure control condition Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 22 continuous mean 151.0 mmHg 2.0 9.38 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65394 306
SHR.BN-(D4Rat33-D4Rat54)/Jk diastolic blood pressure control condition Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 22 continuous mean 125.0 mmHg 2.0 9.38 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65405 306
SHR.BN-(D4Rat33-D4Rat54)/Jk mean arterial blood pressure control condition Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 22 continuous mean 149.0 mmHg 2.0 9.38 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65407 306
SHR.BN-(D16Rat87-D16Mgh1)/Jk diastolic blood pressure control condition Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 22 continuous mean 135.0 mmHg 2.0 9.38 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65410 306
SHR.BN-(D16Rat87-D16Mgh1)/Jk mean arterial blood pressure control condition Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 22 continuous mean 158.0 mmHg 2.0 9.38 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65412 306
SHR.BN-(D2Rat114-D2Rat123)/Jk heart rate control condition (for 98 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. heart pumping trait male 87 days 22 continuous mean 362.0 beats/min 5.0 23.45 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65417 306
SHR.BN-(D4Rat33-D4Rat54)/Jk heart rate controlled sodium content diet (1 %) (for 14 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. heart pumping trait male 87 days 23 continuous mean 363.0 beats/min 5.0 23.98 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65423 306
SHR/Ola systolic blood pressure control condition Pravenec M, et al., J Hypertens 1989 Mar;7(3):217-21. arterial blood pressure trait male 0 days 29 214.0 mmHg 4.0 21.54 vascular indwelling catheter method carotid artery segment 0 66034 651
BN-Lx/Cub systolic blood pressure control condition Pravenec M, et al., J Hypertens 1989 Mar;7(3):217-21. arterial blood pressure trait male 0 days 8 132.0 mmHg 3.0 8.49 vascular indwelling catheter method carotid artery segment 0 66035 651
WKY/NCruk mean arterial blood pressure air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 arterial blood pressure trait male 105 days 28 median 78.0 mmHg vascular indwelling catheter method left common carotid artery 0 0 66130 102
GH/Omr change in mean arterial blood pressure to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 130 days-144 days 14 0.48 mmHg/ng/kg/min 0.02 0.08 vascular indwelling catheter method left femoral artery and vein 0.0 0 microrenathane catheter; recover for 1 week after surgery slope of map response curve 68339 101
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd left ventricular end-diastolic blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 0.52 mmHg 0.27 0.6 vascular indwelling catheter method 0.0 0 68806 1014
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 111.8 mmHg 3.9 17.87 vascular indwelling catheter method left femoral artery 120.0 0 69527 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (20 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 131.3 mmHg 4.2 15.14 vascular indwelling catheter method left femoral artery 120.0 0 69530 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (100 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 147.2 mmHg 3.9 14.06 vascular indwelling catheter method left femoral artery 120.0 0 69532 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 168.4 mmHg 7.0 25.24 vascular indwelling catheter method left femoral artery 120.0 0 69540 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 9 serial mean 134.7 mmHg 7.4 22.2 vascular indwelling catheter method left femoral artery 120.0 0 69544 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days 20 serial mean 103.2 mmHg 2.8 12.52 vascular indwelling catheter method left femoral artery 10800.0 0 69511 151
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days 16 serial mean 163.0 mmHg 6.4 25.6 vascular indwelling catheter method left femoral artery 10800.0 0 69512 151
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 92 days 21 serial mean 425.4 beats/min 10.5 48.12 vascular indwelling catheter method left femoral artery 10800.0 0 69514 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 93 days 21 serial mean 89.6 mmHg 2.5 11.46 vascular indwelling catheter method left femoral artery 10800.0 0 69517 151
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd left ventricular end-diastolic blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 0.22 mmHg 0.25 0.56 vascular indwelling catheter method 0.0 0 68859 1014
WKHA/Cfd left ventricular end-systolic blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 135.0 mmHg 1.71 3.82 vascular indwelling catheter method 0.0 0 68864 1014
WKHA/Cfd left ventricular end-systolic blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 131.0 mmHg 5.0 11.18 vascular indwelling catheter method 0.0 0 68869 1014
WKY/Cfd maximum rate of positive change in left ventricular blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 8304.0 mmHg/s 596.0 1332.7 vascular indwelling catheter method 0.0 0 68891 1014
WKY/Cfd maximum rate of negative change in left ventricular blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 6808.0 mmHg/s 588.0 1314.81 vascular indwelling catheter method 0.0 0 "rate of maximum negative change in left ventricular blood pressure" mmHg/s 68902 1014
WKHA/Cfd maximum rate of negative change in left ventricular blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 5901.0 mmHg/s 507.0 1133.69 vascular indwelling catheter method 0.0 0 68904 1014
WKHA/Cfd maximum rate of negative change in left ventricular blood pressure artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait male 84 days-154 days 5 6859.0 mmHg/s 460.0 1028.59 vascular indwelling catheter method 0.0 0 68905 1014
WKHA/Cfd maximum rate of negative change in left ventricular blood pressure sham surgical control condition Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 6612.0 mmHg/s 308.0 688.71 vascular indwelling catheter method 0.0 0 68910 1014
WKY.SHR-(D1Mgh14-D1Rat77)/Iwai diastolic blood pressure controlled sodium content diet (8 %) (for 14 days) then controlled exposure to darkness (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 126 days 8 96.8 mmHg 0.88 2.5 vascular indwelling catheter method left common carotid artery 0.0 0 nighttime (7 PM - 7 AM) 70096 1281
WKY/NCrl diastolic blood pressure controlled exposure to ambient light (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 112 days 7 88.7 mmHg 0.83 2.2 vascular indwelling catheter method left common carotid artery 0.0 0 daytime (7 AM - 7 PM) 70083 1281
WKY.SHR-(D1Mgh14-D1Rat77)/Iwai systolic blood pressure controlled exposure to ambient light (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 112 days 8 125.5 mmHg 0.57 1.6 vascular indwelling catheter method left common carotid artery 0.0 0 daytime (7 AM - 7 PM) 70089 1281
WKY.SHR-(D1Mgh14-D1Rat77)/Iwai systolic blood pressure controlled sodium content diet (8 %) (for 14 days) then controlled exposure to darkness (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 126 days 8 136.2 mmHg 1.03 2.9 vascular indwelling catheter method left common carotid artery 0.0 0 nighttime (7 PM - 7 AM) 70094 1281
WKY/Izm absolute change in mean arterial blood pressure air-jet exposure (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 22.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84537 1120
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure air-jet exposure (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 35.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 84538 1120
WKY/Izm absolute change in mean arterial blood pressure candesartan (1 ug) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 0.0 mmHg 1.0 2.45 vascular indwelling catheter method 0.0 0 84567 1120
WKY/Izm absolute change in mean arterial blood pressure candesartan (1 ug) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) then phenylephrine (3 ug) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 53.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 84571 1120
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure vehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) then phenylephrine (3 ug) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 50.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 84572 1120
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm heart rate control condition Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. heart pumping trait male 98 days 6 329.0 beats/min 13.0 31.84 vascular indwelling catheter method 0.0 0 84561 1120
WKY/Izm absolute change in heart rate air-jet exposure (for 0 hours) then candesartan (1 ug) (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. heart pumping trait male 98 days 6 -5.0 beats/min 11.0 26.94 vascular indwelling catheter method 0.0 0 84563 1120
WKY/Izm mean arterial blood pressure control condition Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 107.0 mmHg 4.0 9.8 vascular indwelling catheter method 0.0 0 84547 1120
MW mean arterial blood pressure nephrectomy (for 28 days) then reserpine (5 mg/l) (for 21 days) and hydralazine (80 mg/l) (for 21 days) and controlled hydralazine content drinking water (25 mg/l) (for 21 days) Anderson S, et al., J Clin Invest. 1986 Jun;77(6):1993-2000. arterial blood pressure trait male 0 days 8 undefined 107.0 mmHg 3.0 8.49 vascular indwelling catheter method 0.0 5/6 nephrectomy 28 days 100997 2561
MW mean arterial blood pressure unilateral nephrectomy (for 70 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 7 undefined 108.0 mmHg 2.0 5.29 vascular indwelling catheter method 0.0 unx 70 days 101173 2581
SS/JrIpcv diastolic blood pressure controlled sodium content diet (0.3 %) Hojn¿ S, et al., Physiol Res. 2005;54(2):201-6. arterial blood pressure trait male 0 days 0 undefined 108.0 mmHg 3.0 vascular indwelling catheter method 0.0 0 102400 2688
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then cyclosporine A (2.5 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 398.0 beats/min 16.0 39.19 vascular indwelling catheter method 0.0 0 104774 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 103.0 mmHg 12.0 29.39 vascular indwelling catheter method 0.0 0 104777 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 92.0 mmHg 6.0 14.7 vascular indwelling catheter method 0.0 0 104801 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 127.0 mmHg 4.0 9.8 vascular indwelling catheter method 0.0 0 104675 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then dihydrocapsaicin (3 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 420.0 beats/min 9.0 22.05 vascular indwelling catheter method 0.0 0 104697 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 350.0 beats/min 8.0 19.6 vascular indwelling catheter method 0.0 0 104702 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then cyclosporine A (2.5 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 89.0 mmHg 4.0 9.8 vascular indwelling catheter method 0.0 0 104719 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then Capsazepine (3 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 5 89.0 mmHg 3.0 6.71 vascular indwelling catheter method 0.0 0 104727 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 118.0 mmHg 7.0 17.15 vascular indwelling catheter method 0.0 0 104753 2988
SHRSP/A3NCrl mean arterial blood pressure controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. arterial blood pressure trait male 99 days-141 days 9 serial mean 192.0 mmHg 10.0 30.0 vascular indwelling catheter method femoral artery 432000.0 0 10 seconds every 5 minutes for 24hr high salt high fat diet group baseline and after treatment 107048 3073
HsdCpb:WU left ventricular end-diastolic blood pressure sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart left ventricular blood pressure trait male 84 days 5 5.3 mmHg 2.4 5.37 vascular indwelling catheter method heart left ventricle 0.0 0 108776 3130
HsdCpb:WU maximum rate of positive change in left ventricular blood pressure left anterior descending coronary artery occlusion Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. heart left ventricular blood pressure trait male 175 days 6 7463.0 mmHg/s 375.0 918.56 vascular indwelling catheter method heart left ventricle 0.0 0 108851 3130
MWF/Hsd systemic vascular resistance sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. arterial blood pressure trait male 168 days 9 0.81 mmHg/ml/min 0.07 0.21 vascular indwelling catheter method 0.0 0 108892 3130
MWF/Hsd renal vascular resistance sham surgical control condition Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19. arterial blood pressure trait male 175 days 9 52.8 mmHg/ml/min 13.1 39.3 vascular indwelling catheter method 0.0 0 108895 3130
SS/Hsd heart rate aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. heart pumping trait male 49 days-56 days 0 513.0 beats/min 19.0 vascular indwelling catheter method 0.0 0 138357 2801
SR/Hsd mean arterial blood pressure artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 0 107.0 mmHg 2.0 vascular indwelling catheter method 0.0 0 138366 2801
SS/Hsd percent change in mean arterial blood pressure artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) then air-jet exposure (1-1.5 lb/in2) (for 0 hours) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 0 8.0 % 2.0 vascular indwelling catheter method 0.0 0 138372 2801
SS/Hsd percent change in mean arterial blood pressure aldosterone (22.5 ng/hr) (for 14 days) then air-jet exposure (1-1.5 lb/in2) (for 0 hours) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 0 19.0 % 3.0 vascular indwelling catheter method 0.0 0 138373 2801
SS/Hsd mean arterial pressure at the midpoint of a range of heart rates artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 7 110.0 mmHg 2.0 5.29 vascular indwelling catheter method 0.0 0 138440 2801
SS/Hsd mean arterial blood pressure aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.14 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 0 111.0 mmHg 3.0 vascular indwelling catheter method 0.0 0 138448 2801
SS/Hsd range of heart rate variation during variation of mean arterial blood pressure artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. heart pumping trait male 49 days-56 days 7 232.0 beats/min 20.0 52.92 vascular indwelling catheter method 0.0 0 change in heart rate to change in mean arterial blood pressure ratio (range) (CMO:0003896) 138432 2801
GH/Omr change in heart rate to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart pumping trait male 132 days-146 days 14 -0.87 (beats/min)/(ug/kg) 0.07 0.25 vascular indwelling catheter method 0.0 0 ng/kg/min change in heart rate to change in vasoactive chemical dose ratio (CMO:0003904), (beats/min)/(ug/kg) 138468 101
SHR diastolic blood pressure control condition Frantz SA, et al., Hypertension 1998 Oct;32(4):639-46 arterial blood pressure trait male 175 days 28 continuous mean 148.3 mmHg 2.12 11.2 vascular indwelling catheter method aorta 0 11904 206
SHR.WKY-(D1Wox19-D1Wox34)/Njs diastolic blood pressure control condition Frantz SA, et al., Hypertension 1998 Oct;32(4):639-46 arterial blood pressure trait male 175 days 31 continuous mean 139.2 mmHg 2.25 12.5 vascular indwelling catheter method aorta 0 11909 206
GH/Omr mean arterial blood pressure control condition Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 127 days-143 days 21 serial mean 155.7 mmHg 3.06 14.0 vascular indwelling catheter method left femoral artery and vein 4 hrs/day for 3 days 0 microrenathane catheter; recover for 1 week after surgery 11521 101
HTG systolic blood pressure control condition Ueno T, et al., Physiol Genomics 2004 Mar 12;17(1):38-47. arterial blood pressure trait male 151 days-181 days 10 156.4 mmHg 2.1 6.64 vascular indwelling catheter method carotid artery and jugular vein 0 polyethylene catheter 11711 120
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89 days-92 days 21 serial mean 110.0 mmHg 3.0 13.75 vascular indwelling catheter method left femoral artery 0 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 11853 151
BN.GH-(D6Mit12-D6Rat15)/Mcwi heart rate control condition Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart pumping trait male 127 days-143 days 16 serial mean 381.3 beats/min 8.0 32.0 vascular indwelling catheter method left femoral artery and vein 4 hrs/day for 3 days 0 microrenathane catheter; recover for 1 week after surgery 11538 101
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days 16 serial mean 208.0 mmHg 7.6 30.4 vascular indwelling catheter method left femoral artery 10800.0 0 69510 151
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 93 days 11 serial mean 183.0 mmHg 10.0 33.17 vascular indwelling catheter method left femoral artery 10800.0 0 69516 151
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 94 days 11 serial mean 182.9 mmHg 4.1 13.6 vascular indwelling catheter method left femoral artery 10800.0 0 69522 151
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 89 days-91 days 15 serial mean 442.0 beats/min 6.5 25.17 vascular indwelling catheter method left femoral artery 0.0 0 69450 151
WKY.WKHA-(D5Rat45-D5Rat245)/Cfd time constant of left ventricular pressure decay artificial aortocaval fistula Souzeau E, et al., Hypertension. 2006 Jan;47(1):128-33. Epub 2005 Dec 12. heart left ventricular blood pressure trait female 84 days-154 days 5 12.1 ms 1.9 4.25 vascular indwelling catheter method 0.0 0 68925 1014
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 345.0 beats/min 6.0 14.7 vascular indwelling catheter method 0.0 0 104666 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion then dihydrocapsaicin (1 mg/kg) (for 0.7 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 353.0 beats/min 11.0 26.94 vascular indwelling catheter method 0.0 0 104669 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion then cyclosporine A (2.5 mg/kg) (for 0.7 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 410.0 beats/min 11.0 26.94 vascular indwelling catheter method 0.0 0 104674 2988
SD-Trpv1em1Sage+/+ heart rate thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.2 hours) then cyclosporine A (2.5 mg/kg) (for 0.9 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. heart pumping trait male 56 days-70 days 6 433.0 beats/min 10.0 24.49 vascular indwelling catheter method 0.0 0 104701 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then dihydrocapsaicin (0.3 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 85.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 104722 2988
SD-Trpv1em1Sage+/+ mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then V1-Cal (1 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 85.0 mmHg 4.0 9.8 vascular indwelling catheter method 0.0 0 104803 2988
SD-Trpv1em1Sage-/- mean arterial blood pressure thiobutabarbital (100 mg/kg) then left anterior descending coronary artery occlusion (for 0.5 hours) then V1-Cal (1 mg/kg) (for 3.2 hours) then Myocardial reperfusion (for 2 hours) Hurt CM, et al., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774. arterial blood pressure trait male 56 days-70 days 6 84.0 mmHg 8.0 19.6 vascular indwelling catheter method 0.0 0 104806 2988
SS/Hsd mean arterial blood pressure artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days) Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30. arterial blood pressure trait male 52 days-61 days 0 106.0 mmHg 2.0 vascular indwelling catheter method 0.0 0 138381 2801
WKY/Izm absolute change in mean arterial blood pressure air-jet exposure (for 0 hours) then candesartan (1 ug) (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 0.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84552 1120
SHR diastolic blood pressure controlled sodium content drinking water (1 %) (for 15 days) Aneas I, et al., Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. arterial blood pressure trait male 99 days 24 continuous mean 144.0 mmHg 2.0 9.8 vascular indwelling catheter method femoral artery 1800 0 pressure transducer (P23Dd; Stathan, Hato Rey, Puerto Rico), amplifier (GPA-4 model 2; Stemtech, Wood Dale, IL), 10-bit analog-to- digital converter (DataQ Instruments, Akron, OH) 65349 306
LN/MavRrrc absolute change in diastolic blood pressure trimethaphan camsylate (10 mg/kg) (for 0.2 hours) Vincent M, et al., J Clin Invest 1997 Oct 15;100(8):2000-6 arterial blood pressure trait not specified 203 days-217 days 15 serial mean -43.5 mmHg 1.76 6.8 vascular indwelling catheter method abdominal aorta 3600 0 65265 121
SHR.WKY-(D1Wox34-D1Rat164)/Njs diastolic blood pressure control condition Frantz S, et al., Hypertension 2001 Aug;38(2):216-21 arterial blood pressure trait male 196 days 18 135.0 mmHg 2.5 10.6 vascular indwelling catheter method