SS/NEisSlc |
heart left ventricle plus septum weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) then 0.9% sodium chloride solution (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart left ventricle mass |
male |
77 days
| 14 |
2.54 |
mg/g |
0.03 |
0.13 |
post excision weight measurement |
0.0 |
0 |
heart left ventricle plus septum weight to body weight ratio (CMO:0003869) |
102460 |
2689 |
SS/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney mass |
male |
63 days
| 8 |
3.91 |
g/kg |
0.05 |
0.14 |
post excision weight measurement |
0.0 |
0 |
|
102424 |
2689 |
SS/NEisSlc |
kidney weight |
controlled sodium content diet (0.3 %) (for 91 days) |
Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. |
kidney mass |
male |
91 days
| 6 |
1.51 |
g |
0.02 |
0.06 |
post excision weight measurement |
0.0 |
0 |
|
100702 |
2519 |
SS/NEisSlc |
kidney weight |
controlled sodium content diet (0.3 %) (for 49 days) then controlled sodium content diet (8 %) (for 42 days) then cilazapril (10 mg/kg/d) (for 42 days) |
Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. |
kidney mass |
male |
91 days
| 6 |
1.38 |
g |
0.04 |
0.1 |
post excision weight measurement |
0.0 |
0 |
|
100704 |
2519 |
SS/NEisSlc |
both kidneys wet weight to body weight ratio |
controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then tolvaptan (0.05 %) (for 49 days) |
Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. |
kidney mass |
male |
126 days
| 8 |
4.55 |
g/kg |
0.06 |
0.17 |
post excision weight measurement |
0.0 |
0 |
|
102324 |
2684 |
SS/NEisSlc |
heart left ventricle weight |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricle mass |
male |
77 days
| 10 |
1.15 |
g |
0.0 |
0.0 |
post excision weight measurement |
0.0 |
0 |
|
102486 |
2690 |
SS/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney mass |
male |
77 days
| 8 |
4.64 |
g/kg |
0.07 |
0.19 |
post excision weight measurement |
0.0 |
0 |
|
102428 |
2689 |
SS/NEisSlc |
heart weight |
controlled sodium content diet (8 %) (for 42 days) then candesartan (1 mg/kg/d) (for 42 days) |
Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. |
heart mass |
male |
91 days
| 6 |
1.49 |
g |
0.05 |
0.12 |
post excision weight measurement |
0.0 |
0 |
|
100710 |
2519 |
SS/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium content diet (8 %) (for 42 days) then 0.9% sodium chloride solution (0.3 ml) (for 42 days) |
Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. |
kidney mass |
male |
91 days
| 12 |
5.37 |
g/kg |
0.11 |
0.38 |
post excision weight measurement |
0.0 |
0 |
|
100711 |
2519 |
SS/NEisSlc |
heart weight to body weight ratio |
controlled sodium content diet (8 %) (for 42 days) then 0.9% sodium chloride solution (0.3 ml) (for 42 days) |
Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. |
heart mass |
male |
91 days
| 12 |
4.15 |
g/kg |
0.1 |
0.35 |
post excision weight measurement |
0.0 |
0 |
|
100716 |
2519 |
SS/NEisSlc |
heart weight to body weight ratio |
controlled sodium content diet (8 %) (for 42 days) then cilazapril (10 mg/kg/d) (for 42 days) |
Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. |
heart mass |
male |
91 days
| 6 |
4.32 |
g/kg |
0.07 |
0.17 |
post excision weight measurement |
0.0 |
0 |
|
100719 |
2519 |
SS/NEisSlc |
heart weight to body weight ratio |
controlled E4177 content drinking water (1.66 mg/kg/d) (for 547.5 days) |
Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. |
heart mass |
not specified |
547 days
| 10 |
2.8 |
g/kg |
0.1 |
0.32 |
post excision weight measurement |
0.0 |
0 |
|
106795 |
2339 |
SS/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) then 0.9% sodium chloride solution (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney mass |
male |
77 days
| 14 |
4.63 |
g/kg |
0.07 |
0.26 |
post excision weight measurement |
0.0 |
0 |
|
102463 |
2689 |
SS/NEisSlc |
heart left ventricle weight |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricle mass |
male |
126 days
| 10 |
1.31 |
g |
0.0 |
0.01 |
post excision weight measurement |
0.0 |
0 |
|
102487 |
2690 |
SS/NEisSlc |
heart left ventricle plus septum weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart left ventricle mass |
male |
70 days
| 7 |
2.42 |
mg/g |
0.03 |
0.07 |
post excision weight measurement |
0.0 |
0 |
heart left ventricle plus septum weight to body weight ratio (CMO:0003869) |
102420 |
2689 |
SS/NEisSlc |
heart left ventricle plus septum weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart left ventricle mass |
male |
77 days
| 8 |
2.58 |
mg/g |
0.05 |
0.13 |
post excision weight measurement |
0.0 |
0 |
heart left ventricle plus septum weight to body weight ratio (CMO:0003869) |
102422 |
2689 |
SS/NEisSlc |
heart weight to body weight ratio |
controlled sodium content diet (0.3 %) (for 91 days) |
Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. |
heart mass |
male |
91 days
| 6 |
3.17 |
g/kg |
0.06 |
0.15 |
post excision weight measurement |
0.0 |
0 |
|
100717 |
2519 |
SS/NEisSlc |
heart weight to body weight ratio |
vehicle control condition (for 547.5 days) |
Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. |
heart mass |
not specified |
547 days
| 10 |
3.2 |
g/kg |
0.1 |
0.32 |
post excision weight measurement |
0.0 |
0 |
|
106792 |
2339 |
SS/NEisSlc |
heart weight to body weight ratio |
controlled cilazapril content drinking water (0.16 mg/kg/d) (for 547.5 days) |
Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. |
heart mass |
not specified |
547 days
| 10 |
3.0 |
g/kg |
0.1 |
0.32 |
post excision weight measurement |
0.0 |
0 |
|
106793 |
2339 |
SS/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) then adrenomedulin (400 ng/hr) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney mass |
male |
77 days
| 14 |
4.52 |
g/kg |
0.07 |
0.27 |
post excision weight measurement |
0.0 |
0 |
|
102464 |
2689 |
SS/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 14 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
kidney mass |
male |
70 days
| 7 |
4.46 |
g/kg |
0.08 |
0.2 |
post excision weight measurement |
0.0 |
0 |
|
102426 |
2689 |
SS/NEisSlc |
heart weight |
controlled sodium content diet (8 %) (for 42 days) then cilazapril (10 mg/kg/d) (for 42 days) |
Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. |
heart mass |
male |
91 days
| 6 |
1.38 |
g |
0.04 |
0.1 |
post excision weight measurement |
0.0 |
0 |
|
100709 |
2519 |
SS/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium content diet (8 %) (for 42 days) then cilazapril (10 mg/kg/d) (for 42 days) |
Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. |
kidney mass |
male |
91 days
| 6 |
5.3 |
g/kg |
0.2 |
0.49 |
post excision weight measurement |
0.0 |
0 |
|
100714 |
2519 |
SS/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium content diet (8 %) (for 42 days) then candesartan (1 mg/kg/d) (for 42 days) |
Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. |
kidney mass |
male |
91 days
| 6 |
5.39 |
g/kg |
0.15 |
0.37 |
post excision weight measurement |
0.0 |
0 |
|
100715 |
2519 |
SS/NEisSlc |
both kidneys wet weight to body weight ratio |
controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) |
Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. |
kidney mass |
male |
126 days
| 8 |
5.19 |
g/kg |
0.19 |
0.54 |
post excision weight measurement |
0.0 |
0 |
|
102323 |
2684 |
SS/NEisSlc |
heart left ventricle plus septum weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 21 days) then adrenomedulin (400 ng/hr) (for 21 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart left ventricle mass |
male |
77 days
| 14 |
2.32 |
mg/g |
0.04 |
0.14 |
post excision weight measurement |
0.0 |
0 |
heart left ventricle plus septum weight to body weight ratio (CMO:0003869) |
102461 |
2689 |
SS/NEisSlc |
heart left ventricle weight to body weight ratio |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 35 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricle mass |
male |
77 days
| 10 |
3.35 |
mg/g |
0.12 |
0.38 |
post excision weight measurement |
0.0 |
0 |
|
102490 |
2690 |
SS/NEisSlc |
heart left ventricle weight to body weight ratio |
controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 84 days) |
Horinaka S, et al., Int J Cardiol. 2003 Sep;91(1):25-35. |
heart left ventricle mass |
male |
126 days
| 10 |
4.39 |
mg/g |
0.08 |
0.24 |
post excision weight measurement |
0.0 |
0 |
|
102491 |
2690 |
SS/NEisSlc |
heart left ventricle plus septum weight to body weight ratio |
controlled sodium chloride content diet (8 %) (for 7 days) |
Yoshihara F, et al., Regul Pept. 2005 May 15;128(1):7-13. |
heart left ventricle mass |
male |
63 days
| 8 |
2.19 |
mg/g |
0.02 |
0.07 |
post excision weight measurement |
0.0 |
0 |
heart left ventricle plus septum weight to body weight ratio (CMO:0003869) |
102418 |
2689 |
SS/NEisSlc |
heart weight to body weight ratio |
controlled sodium content diet (8 %) (for 42 days) then candesartan (1 mg/kg/d) (for 42 days) |
Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. |
heart mass |
male |
91 days
| 6 |
4.36 |
g/kg |
0.18 |
0.44 |
post excision weight measurement |
0.0 |
0 |
|
100720 |
2519 |
SS/NEisSlc |
kidney weight |
controlled sodium content diet (8 %) (for 42 days) then 0.9% sodium chloride solution (0.3 ml) (for 42 days) |
Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. |
kidney mass |
male |
91 days
| 12 |
1.83 |
g |
0.03 |
0.11 |
post excision weight measurement |
0.0 |
0 |
|
100701 |
2519 |
SS/NEisSlc |
kidney weight |
controlled sodium content diet (8 %) (for 42 days) then candesartan (1 mg/kg/d) (for 42 days) |
Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. |
kidney mass |
male |
91 days
| 6 |
1.84 |
g |
0.05 |
0.12 |
post excision weight measurement |
0.0 |
0 |
|
100705 |
2519 |
SS/NEisSlc |
heart weight |
controlled sodium content diet (8 %) (for 42 days) then 0.9% sodium chloride solution (0.3 ml) (for 42 days) |
Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. |
heart mass |
male |
91 days
| 12 |
1.44 |
g |
0.03 |
0.1 |
post excision weight measurement |
0.0 |
0 |
|
100706 |
2519 |
SS/NEisSlc |
heart weight |
controlled sodium content diet (0.3 %) (for 91 days) |
Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. |
heart mass |
male |
91 days
| 6 |
1.19 |
g |
0.02 |
0.04 |
post excision weight measurement |
0.0 |
0 |
|
100707 |
2519 |
SS/NEisSlc |
single kidney wet weight to body weight ratio |
controlled sodium content diet (0.3 %) (for 91 days) |
Otsuka F, et al., Am J Physiol. 1998 Jun;274(6 Pt 2):R1797-806. |
kidney mass |
male |
91 days
| 6 |
4.07 |
g/kg |
0.04 |
0.1 |
post excision weight measurement |
0.0 |
0 |
|
100712 |
2519 |
SS/NEisSlc |
heart weight to body weight ratio |
controlled cilazapril content drinking water (0.94 mg/kg/d) (for 547.5 days) |
Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. |
heart mass |
not specified |
547 days
| 10 |
2.8 |
g/kg |
0.1 |
0.32 |
post excision weight measurement |
0.0 |
0 |
|
106794 |
2339 |