F344/DuCrl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
7 
7.85 
null 
0.41 
1.08 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55352 
522 
SSChr 18BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
10 
8.31 
null 
0.08 
0.24 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
55483 
522 
SSChr 18BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
8 
8.22 
null 
0.05 
0.14 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
56003 
522 
SSChr 16BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
10 
8.64 
null 
0.25 
0.8 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
56005 
522 
SSChr 6BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
9 
8.78 
null 
0.16 
0.48 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56020 
522 
FHH/EurMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
11 
8.21 
null 
0.15 
0.49 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56028 
522 
GH/OmrMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
5 
8.14 
null 
0.07 
0.16 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56033 
522 
GH/OmrMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
5 
8.16 
null 
0.06 
0.14 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56036 
522 
SS.BN(D12Arb13D12Rat79)/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
16 
8.53 
null 
0.09 
0.36 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54608 
522 
SSChr 13BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
9 
8.2 
null 
0.09 
0.27 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54620 
522 
FHHChr 1BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
9 
8.24 
null 
0.06 
0.17 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54623 
522 
BN/NHsdMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
20 
8.81 
null 
0.05 
0.21 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54632 
522 
LE/BluGill 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
14 
8.48 
null 
0.06 
0.24 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55116 
522 
GH/OmrMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
10 
8.85 
null 
0.06 
0.19 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
56004 
522 
SS/JrHsdMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
12 
8.51 
null 
0.18 
0.62 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Conversion period. Moms had mixed diet, Dyets and Teklad, for 34 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 
56010 
522 
SSChr 16BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
9 
8.96 
null 
0.17 
0.51 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56022 
522 
SSChr 18BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
10 
7.73 
null 
0.07 
0.21 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56030 
522 
SS/JrHsdMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
7 
8.4 
null 
0.07 
0.2 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56035 
522 
BN/NHsdMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
16 
8.92 
null 
0.07 
0.29 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56041 
522 
SSChr 16BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
9 
7.79 
null 
0.13 
0.38 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54612 
522 
F344/DuCrl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
7 
8.31 
null 
0.08 
0.22 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55347 
522 
SSChr 18BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
10 
8.3 
null 
0.06 
0.2 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
55488 
522 
SHR/NCrl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
10 
7.97 
null 
0.17 
0.54 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
55493 
522 
FHH/EurMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
5 
8.02 
null 
0.03 
0.08 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Conversion period. Moms had mixed diet, Dyets and Teklad, for 34 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 
55499 
522 
WKY/NCrl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
15 
7.84 
null 
0.08 
0.31 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55344 
522 
Crl:CD(SD) 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
19 
8.68 
null 
0.07 
0.32 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55348 
522 
LE/BluGill 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
13 
8.65 
null 
0.07 
0.24 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55349 
522 
SHR/NCrl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
8 
8.58 
null 
0.14 
0.39 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
55487 
522 
GH/OmrMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
8 
8.86 
null 
0.16 
0.44 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
55494 
522 
FHH/EurMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
6 
8.55 
null 
0.25 
0.6 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
56000 
522 
SSChr 16BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
5 
8.5 
null 
0.17 
0.39 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Conversion period. Moms had mixed diet, Dyets and Teklad, for 34 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 
56011 
522 
SSChr 13BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
10 
8.47 
null 
0.08 
0.26 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54614 
522 
SSChr 9BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
10 
8.67 
null 
0.07 
0.21 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54615 
522 
SSChr 6BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
8 
8.46 
null 
0.09 
0.25 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54616 
522 
FHH/EurMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
2 
8.59 
null 
0.11 
0.15 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54619 
522 
SS/JrHsdMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
53 
8.39 
null 
0.06 
0.41 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54622 
522 
SS.BN(D8Rat163D8Rat81)/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
10 
8.5 
null 
0.09 
0.3 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54630 
522 
BN/NHsdMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
19 
8.78 
null 
0.08 
0.36 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54631 
522 
FHHChr 1BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
9 
8.32 
null 
0.22 
0.66 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54633 
522 
SS.BN(D12Arb13D12Rat79)/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
15 
8.57 
null 
0.06 
0.24 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56023 
522 
SS/JrHsdMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
52 
8.49 
null 
0.07 
0.48 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56031 
522 
SSChr 18BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
9 
8.05 
null 
0.09 
0.27 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56034 
522 
SS.BN(D8Rat163D8Rat81)/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
10 
8.12 
null 
0.08 
0.26 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56039 
522 
FHHChr 1BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
19 
8.75 
null 
0.14 
0.62 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56042 
522 
LEW/Crl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
21 
8.82 
null 
0.1 
0.47 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55117 
522 
WKY/NCrl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
14 
7.97 
null 
0.09 
0.35 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55111 
522 
SSChr 16BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
7 
8.43 
null 
0.09 
0.23 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54609 
522 
SS/JrHsdMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
12 
8.64 
null 
0.12 
0.42 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
56007 
522 
FHHChr 12BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
3 
8.38 
null 
0.31 
0.54 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56015 
522 
SSChr 9BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
9 
8.32 
null 
0.04 
0.11 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56024 
522 
Hsd:SD 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
16 
7.49 
null 
0.05 
0.22 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 
55247 
522 
SSChr 16BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
5 
9.16 
null 
0.07 
0.16 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Conversion period. Moms had mixed diet, Dyets and Teklad, for 34 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 
55497 
522 
SS/JrHsdMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
12 
8.42 
null 
0.12 
0.4 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
55492 
522 
SSChr 18BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
10 
8.02 
null 
0.04 
0.13 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
55998 
522 
GH/OmrMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
10 
8.81 
null 
0.07 
0.23 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
56009 
522 
SSChr 9BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
10 
8.42 
null 
0.04 
0.14 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54611 
522 
FHHChr 12BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
11 
8.28 
null 
0.04 
0.14 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54617 
522 
SSChr YBN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
18 
8.3 
null 
0.05 
0.2 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54621 
522 
SSChr 7BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
11 
8.42 
null 
0.08 
0.26 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54625 
522 
GH/OmrMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
5 
8.35 
null 
0.06 
0.14 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54626 
522 
SSChr 2BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
11 
8.57 
null 
0.09 
0.3 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54629 
522 
SS.BN(D12Arb13D12Rat79)/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
14 
8.48 
null 
0.05 
0.18 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56018 
522 
SSChr 9BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
10 
8.43 
null 
0.04 
0.14 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56021 
522 
SS.BN(D8Rat163D8Rat81)/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
6 
8.36 
null 
0.1 
0.24 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56037 
522 
BN/NHsdMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
20 
8.63 
null 
0.09 
0.4 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56040 
522 
F344/DuCrl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
11 
8.29 
null 
0.39 
1.29 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55119 
522 
Hsd:SD 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
17 
8.25 
null 
0.17 
0.7 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 
55701 
522 
SSChr 16BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
10 
8.96 
null 
0.07 
0.23 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
56001 
522 
FHHChr 12BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
3 
8.44 
null 
0.1 
0.17 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54606 
522 
SSChr 2BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
14 
8.76 
null 
0.1 
0.36 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56038 
522 
FHH/EurMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
6 
8.67 
null 
0.11 
0.28 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
55491 
522 
WKY/NCrl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
12 
8.53 
null 
0.12 
0.42 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55351 
522 
SSChr 16BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
10 
8.43 
null 
0.1 
0.3 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
55486 
522 
GH/OmrMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
8 
8.8 
null 
0.1 
0.3 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
55489 
522 
SSChr 16BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
10 
8.36 
null 
0.11 
0.33 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
55490 
522 
SS/JrHsdMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
13 
8.62 
null 
0.14 
0.49 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Conversion period. Moms had mixed diet, Dyets and Teklad, for 34 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 
55495 
522 
SHR/NCrl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
7 
8.58 
null 
0.12 
0.32 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
56002 
522 
SHR/NCrl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
7 
8.77 
null 
0.21 
0.54 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
56008 
522 
SS/JrHsdMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
8 
8.43 
null 
0.08 
0.23 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Conversion period. Moms had mixed diet, Dyets and Teklad, for 34 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 
56012 
522 
SSChr 20BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
10 
8.52 
null 
0.03 
0.11 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56017 
522 
FHHChr 12BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
7 
8.41 
null 
0.1 
0.26 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56026 
522 
SSChr 2BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
10 
8.41 
null 
0.2 
0.62 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56043 
522 
GH/OmrMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
5 
8.36 
null 
0.04 
0.09 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54624 
522 
SS.BN(D8Rat163D8Rat81)/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
9 
8.89 
null 
0.11 
0.33 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54627 
522 
Crl:CD(SD) 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
10 
8.3 
null 
0.05 
0.16 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55113 
522 
SSChr 20BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
10 
8.35 
null 
0.09 
0.28 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56027 
522 
FHHChr 1BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
18 
8.5 
null 
0.12 
0.5 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56032 
522 
Crl:CD(SD) 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
9 
8.48 
null 
0.05 
0.16 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55115 
522 
WKY/NCrl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
9 
8.34 
null 
0.07 
0.21 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55118 
522 
LE/BluGill 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
11 
8.48 
null 
0.13 
0.41 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55353 
522 
FHH/EurMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
6 
8.29 
null 
0.34 
0.83 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
55485 
522 
FHH/EurMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
5 
8.29 
null 
0.1 
0.23 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Conversion period. Moms had mixed diet, Dyets and Teklad, for 34 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 
55496 
522 
Crl:CD(SD) 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
18 
8.19 
null 
0.1 
0.41 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55346 
522 
SHR/NCrl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
8 
8.36 
null 
0.09 
0.26 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Conversion period. Moms had mixed diet, Dyets and Teklad, for 34 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 
55498 
522 
SS/JrHsdMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
8 
8.43 
null 
0.04 
0.1 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Conversion period. Moms had mixed diet, Dyets and Teklad, for 34 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 
55500 
522 
SS/JrHsdMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
11 
8.49 
null 
0.13 
0.42 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
55484 
522 
FHH/EurMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
5 
8.92 
null 
0.12 
0.27 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
56006 
522 
Hsd:SD 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
14 
8.91 
null 
0.05 
0.19 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 
55702 
522 
FHH/EurMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
5 
8.51 
null 
0.07 
0.17 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56016 
522 
SSChr 6BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
10 
8.37 
null 
0.05 
0.16 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56025 
522 
SSChr YBN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
20 
8.7 
null 
0.08 
0.35 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56029 
522 
SSChr 20BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
10 
8.79 
null 
0.1 
0.31 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54607 
522 
SSChr 6BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
9 
8.63 
null 
0.12 
0.35 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54610 
522 
SS.BN(D12Arb13D12Rat79)/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
14 
8.61 
null 
0.06 
0.24 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54613 
522 
SSChr 20BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
31 
8.52 
null 
0.05 
0.31 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54618 
522 
SSChr 7BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
10 
8.47 
null 
0.09 
0.29 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54628 
522 
SSChr 2BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
12 
8.47 
null 
0.11 
0.37 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
54634 
522 
F344/DuCrl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
14 
8.38 
null 
0.09 
0.32 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55114 
522 
LE/BluGill 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
14 
8.28 
null 
0.06 
0.24 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55120 
522 
SS/JrHsdMcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
14 
8.35 
null 
0.1 
0.37 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Dyets 
55999 
522 
SSChr 16BN/Mcwi 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
9 
8.98 
null 
0.13 
0.4 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms and pups used in studies were fed Teklad 
56019 
522 
LEW/Crl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
23 
9.04 
null 
0.06 
0.29 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55112 
522 
Hsd:SD 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
16 
7.54 
null 
0.06 
0.26 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 
55246 
522 
LEW/Crl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
female 
70 days84 days 
21 
8.69 
null 
0.08 
0.36 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55345 
522 
LEW/Crl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
20 
8.57 
null 
0.08 
0.37 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 
55350 
522 
SHR/NCrl 
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) 
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (03 umol/l) and drug dose time series (for 1 hours) 
PhysGen Vascular data 
vasodilation trait 
male 
70 days84 days 
9 
8.34 
null 
0.06 
0.17 
Download Values

wire myography using a DigiMed tissue force analysis system with force transducer 

0 
Conversion period. Moms had mixed diet, Dyets and Teklad, for 34 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 
55501 
522 