PXO6-3/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 10 |
43.66 |
mg/dl |
1.74 |
5.5 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97308 |
1858 |
PXO8-2/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 13 |
45.31 |
mg/dl |
1.29 |
4.65 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97309 |
1858 |
PXO2/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 11 |
46.23 |
mg/dl |
1.97 |
6.53 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97313 |
1858 |
SS.ZUC-Leprfa+/+/Slc |
blood high density lipoprotein cholesterol level |
everolimus (0.83 mg/kg/d) (for 28 days) |
Uchinaka A, et al., Pharmacol Res Perspect. 2017 Aug;5(4). doi: 10.1002/prp2.331. |
blood HDL cholesterol amount |
male |
91 days
| 10 |
22.5 |
mg/dl |
2.27 |
7.18 |
blood cholesterol analysis |
0.0 |
0 |
|
101842 |
2641 |
SS.ZUC-Leprfa-/-/Slc |
blood high density lipoprotein cholesterol level |
everolimus (0.83 mg/kg/d) (for 28 days) |
Uchinaka A, et al., Pharmacol Res Perspect. 2017 Aug;5(4). doi: 10.1002/prp2.331. |
blood HDL cholesterol amount |
male |
91 days
| 12 |
67.83 |
mg/dl |
15.23 |
52.76 |
blood cholesterol analysis |
0.0 |
0 |
|
101844 |
2641 |
PXO1/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 11 |
27.54 |
mg/dl |
1.8 |
5.97 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97299 |
1858 |
Slc:W |
blood high density lipoprotein cholesterol level |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood HDL cholesterol amount |
male |
105 days
| 0 |
4.2 |
mg/dl |
0.3 |
|
blood high-density lipoprotein-cholesterol measurement test |
0.0 |
0 |
n=4-6 |
102894 |
2781 |
PXO7-1/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 8 |
36.57 |
mg/dl |
0.82 |
2.32 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97305 |
1858 |
SHR.BN-(D8Mit5-D8Mgh6)/Ipcv |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 13 |
25.67 |
mg/dl |
0.67 |
2.42 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97298 |
1858 |
PXO6-1/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 10 |
31.15 |
mg/dl |
1.38 |
4.36 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97301 |
1858 |
PXO5-2/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 10 |
32.16 |
mg/dl |
1.52 |
4.81 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97302 |
1858 |
PXO3-1/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 10 |
41.19 |
mg/dl |
1.06 |
3.35 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97306 |
1858 |
Slc:W |
blood high density lipoprotein cholesterol level |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood HDL cholesterol amount |
male |
105 days
| 0 |
5.2 |
mg/dl |
0.7 |
|
blood high-density lipoprotein-cholesterol measurement test |
0.0 |
0 |
n=4-6 |
102895 |
2781 |
GK/Slc |
blood high density lipoprotein cholesterol level |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood HDL cholesterol amount |
male |
105 days
| 0 |
9.0 |
mg/dl |
0.9 |
|
blood high-density lipoprotein-cholesterol measurement test |
0.0 |
0 |
n=4-6 |
102896 |
2781 |
GK/Slc |
blood high density lipoprotein cholesterol level |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood HDL cholesterol amount |
male |
105 days
| 0 |
7.0 |
mg/dl |
0.7 |
|
blood high-density lipoprotein-cholesterol measurement test |
0.0 |
0 |
n=4-6 |
102897 |
2781 |
SS.ZUC-Leprfa+/+/Slc |
blood high density lipoprotein cholesterol level |
control condition |
Uchinaka A, et al., Pharmacol Res Perspect. 2017 Aug;5(4). doi: 10.1002/prp2.331. |
blood HDL cholesterol amount |
male |
91 days
| 8 |
13.05 |
mg/dl |
2.54 |
7.18 |
blood cholesterol analysis |
0.0 |
0 |
|
101841 |
2641 |
PXO10/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 12 |
22.0 |
mg/dl |
1.47 |
5.09 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97297 |
1858 |
BXH2/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 18 |
28.01 |
mg/dl |
2.08 |
8.82 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97300 |
1858 |
PXO9/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 9 |
32.9 |
mg/dl |
2.96 |
8.88 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97303 |
1858 |
PXO4/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 9 |
43.61 |
mg/dl |
0.92 |
2.76 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97307 |
1858 |
PXO3-2/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 9 |
46.2 |
mg/dl |
2.14 |
6.42 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97312 |
1858 |
PXO5-1/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 11 |
36.37 |
mg/dl |
1.47 |
4.88 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97304 |
1858 |
PXO6-2/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 8 |
46.13 |
mg/dl |
1.76 |
4.98 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97311 |
1858 |
PXO8-1/Cub |
blood high density lipoprotein cholesterol level |
controlled sucrose content diet (70 % of calories) (between 0 and 168 hours) and controlled protein content diet (19.6 % of calories) (between 0 and 168 hours) and controlled fat content diet (10.4 % of calories) (between 0 and 168 hours) then fasting (between 0 and 16 hours) |
Hodulova M, et al., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014. |
blood HDL cholesterol amount |
male |
127 days
| 10 |
45.97 |
mg/dl |
1.02 |
3.23 |
enzymatic cholesterol assay |
0.0 |
0 |
|
97310 |
1858 |
SS.ZUC-Leprfa-/-/Slc |
blood high density lipoprotein cholesterol level |
control condition |
Uchinaka A, et al., Pharmacol Res Perspect. 2017 Aug;5(4). doi: 10.1002/prp2.331. |
blood HDL cholesterol amount |
male |
91 days
| 7 |
73.0 |
mg/dl |
15.83 |
41.88 |
blood cholesterol analysis |
0.0 |
0 |
|
101843 |
2641 |