Phenominer Database Results (25 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Record ID Study ID
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 87 days 5 83.0 uV 7.0 15.65 electroretinography cornea 0.0 plasmid delivery 71 days pVAX2-rGDNF scotopic b-wave ERG 108735 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 70 days 3 26.7 uV 2.7 4.68 electroretinography cornea 0.0 plasmid delivery 54 days pVAX2-rGDNF scotopic a-wave ERG 108747 3131
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 75 days 5 135.0 uV 38.0 84.97 electroretinography cornea 0.0 plasmid delivery 59 days pVAX2-rGDNF scotopic b-wave ERG 108731 3131
RCS-p+/LavRrrc photoreceptor inner segment thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. photoreceptor inner segment morphology trait both 87 days 5 1.5 um 0.4 0.89 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 71 days pVAX2-rGDNF superior hemisphere - photoreceptor IS 108723 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 53 days 5 96.3 uV 10.3 23.03 electroretinography cornea 0.0 plasmid delivery 37 days pVAX2-rGDNF scotopic a-wave ERG 108725 3131
RCS-p+/LavRrrc retinal inner layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal inner nuclear layer morphology trait both 70 days 4 28.3 um 1.3 2.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere 108739 3131
RCS-p+/LavRrrc retinal outer nuclear layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal outer nuclear layer morphology trait both 70 days 4 16.8 um 1.9 3.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere 108741 3131
RCS-p+/LavRrrc photoreceptor inner segment thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. photoreceptor inner segment morphology trait both 70 days 4 5.2 um 1.2 2.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere 108745 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 70 days 3 20.9 uV 3.7 6.41 electroretinography cornea 0.0 plasmid delivery 54 days pVAX2-rGDNF scotopic a-wave ERG 108748 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 87 days 5 17.1 uV 3.2 7.16 electroretinography cornea 0.0 plasmid delivery 71 days pVAX2-rGDNF scotopic a-wave ERG 108733 3131
RCS-p+/LavRrrc retinal inner nuclear layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal inner nuclear layer morphology trait both 51 days 5 26.3 um 1.5 3.35 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 35 days pVAX2-rGDNF retinal inner nuclear layer thickness (CMO:0003668) 108707 3131
RCS-p+/LavRrrc retinal inner layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal inner nuclear layer morphology trait both 87 days 5 21.4 um 0.7 1.57 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 71 days pVAX2-rGDNF superior hemisphere 108719 3131
RCS-p+/LavRrrc retinal inner layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal inner nuclear layer morphology trait both 70 days 4 32.2 um 1.6 3.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere 108738 3131
RCS-p+/LavRrrc retinal outer nuclear layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal outer nuclear layer morphology trait both 70 days 4 10.6 um 1.7 3.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere 108742 3131
RCS-p+/LavRrrc photoreceptor inner segment thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. photoreceptor inner segment morphology trait both 70 days 4 8.3 um 1.7 3.4 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere 108744 3131
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 53 days 5 475.0 uV 41.0 91.68 electroretinography cornea 0.0 plasmid delivery 37 days pVAX2-rGDNF scotopic b-wave ERG 108727 3131
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 70 days 3 199.0 uV 17.0 29.44 electroretinography cornea 0.0 plasmid delivery 54 days pVAX2-rGDNF scotopic b-wave ERG 108750 3131
RCS-p+/LavRrrc scotopic B wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 70 days 3 144.0 uV 29.0 50.23 electroretinography cornea 0.0 plasmid delivery 54 days pVAX2-rGDNF scotopic b-wave ERG 108751 3131
RCS-p+/LavRrrc photoreceptor inner segment thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. photoreceptor inner segment morphology trait both 70 days 5 1.8 um 0.4 0.89 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere - photoreceptor IS 108715 3131
RCS-p+/LavRrrc retinal outer nuclear layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal outer nuclear layer morphology trait both 70 days 5 9.4 um 1.0 2.24 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere 108717 3131
RCS-p+/LavRrrc scotopic A wave amplitude of ERG waveform gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) then controlled exposure to darkness (for 1 days) then visible light stimulus (3 cd x s/m2) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. rod electrophysiology trait both 75 days 5 29.7 uV 11.3 25.27 electroretinography cornea 0.0 plasmid delivery 59 days pVAX2-rGDNF scotopic a-wave ERG 108729 3131
RCS-p+/LavRrrc retinal outer nuclear layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal outer nuclear layer morphology trait both 51 days 5 27.7 um 1.1 2.46 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 35 days pVAX2-rGDNF superior hemisphere 108709 3131
RCS-p+/LavRrrc photoreceptor inner segment thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. photoreceptor inner segment morphology trait both 51 days 5 8.1 um 0.4 0.89 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 35 days pVAX2-rGDNF superior hemisphere - photoreceptor IS 108711 3131
RCS-p+/LavRrrc retinal inner layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal inner nuclear layer morphology trait both 70 days 5 27.4 um 0.6 1.34 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 54 days pVAX2-rGDNF superior hemisphere 108713 3131
RCS-p+/LavRrrc retinal outer nuclear layer thickness gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. retinal outer nuclear layer morphology trait both 87 days 5 5.4 um 0.6 1.34 ex vivo light microscopy with histochemistry and digital image analysis 0.0 plasmid delivery 71 days pVAX2-rGDNF superior hemisphere 108721 3131