GK/Jpe |
plasma free fatty acids level |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
blood free fatty acid amount |
male |
540 days
| 10 |
0.89 |
mmol/l |
0.06 |
0.19 |
enzymatic lipid assay |
0.0 |
0 |
|
108018 |
3108 |
GK/Jpe |
serum albumin level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood albumin amount |
male |
540 days
| 7 |
2.4 |
g/dl |
0.04 |
0.11 |
blood protein analysis |
0.0 |
0 |
|
110889 |
3193 |
GK/Jpe |
serum non-high density lipoprotein cholesterol level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood cholesterol amount |
male |
540 days
| 7 |
1.11 |
mmol/l |
0.16 |
0.42 |
colorimetry |
0.0 |
0 |
|
110879 |
3193 |
GK/Jpe |
serum gamma-glutamyltransferase activity level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood gamma-glutamyltransferase amount |
male |
540 days
| 7 |
1.3 |
U/l |
0.2 |
0.53 |
blood enzyme activity assay |
0.0 |
0 |
|
110915 |
3193 |
GK/Jpe |
body weight gain |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
body mass |
male |
450 days-540 days |
10 |
11.9 |
g |
3.7 |
11.7 |
body weighing method |
0.0 |
0 |
|
108003 |
3108 |
GK/Jpe |
blood glucose level |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) then fasting (for 15 hours) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
blood glucose amount |
male |
540 days
| 10 |
122.3 |
mg/dl |
9.3 |
29.41 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
0 |
|
108008 |
3108 |
GK/Jpe |
serum triglyceride level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood triglyceride amount |
male |
540 days
| 7 |
116.81 |
mg/dl |
14.16 |
37.46 |
colorimetry |
0.0 |
0 |
|
110884 |
3193 |
GK/Jpe |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
70.0 |
% |
2.1 |
5.56 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109103 |
3108 |
GK/Jpe |
body weight |
controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and lipoic acid (50 mg/kg) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
body mass |
male |
540 days
| 7 |
433.9 |
g |
10.9 |
28.84 |
body weighing method |
0.0 |
0 |
|
110849 |
3193 |
GK/Jpe |
serum total cholesterol level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood cholesterol amount |
male |
540 days
| 7 |
92.28 |
mg/dl |
10.42 |
27.58 |
colorimetry |
0.0 |
0 |
|
110874 |
3193 |
GK/Jpe |
blood glucose level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood glucose amount |
male |
540 days
| 7 |
363.6 |
mg/dl |
9.0 |
23.81 |
intraperitoneal glucose tolerance test |
0.0 |
0 |
|
110869 |
3193 |
GK/Jpe |
liver weight to body weight ratio |
controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and lipoic acid (50 mg/kg) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
liver mass |
male |
540 days
| 7 |
16.3 |
g/kg |
1.9 |
5.03 |
post excision weight measurement |
0.0 |
0 |
|
110859 |
3193 |
GK/Jpe |
urine albumin excretion rate |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
urine albumin amount |
male |
540 days
| 10 |
17.8 |
mg/d |
2.9 |
9.17 |
urine albumin analysis |
0.0 |
0 |
|
108023 |
3108 |
GK/Jpe |
serum aspartate aminotransferase activity level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood aspartate transaminase amount |
male |
540 days
| 7 |
151.0 |
U/l |
8.7 |
23.02 |
blood enzyme activity assay |
0.0 |
0 |
|
110899 |
3193 |
GK/Jpe |
blood glucose level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood glucose amount |
male |
540 days
| 7 |
122.04 |
mg/dl |
5.4 |
14.29 |
blood glucose test strip read by electrochemical glucometer |
0.0 |
0 |
|
110864 |
3193 |
GK/Jpe |
urine 8-hydroxy-2'-deoxyguanosine level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
urine molecular composition trait |
male |
540 days
| 7 |
5.63 |
ng/d |
0.36 |
0.95 |
enzyme linked immunosorbent assay |
0.0 |
0 |
|
110930 |
3193 |
GK/Jpe |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
-6.25 |
null |
0.07 |
0.19 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109108 |
3108 |
GK/Jpe |
serum uric acid level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood uric acid amount |
male |
540 days
| 7 |
0.02 |
umol/l |
0.0 |
0.0 |
blood uric acid analysis |
0.0 |
0 |
|
110935 |
3193 |
GK/Jpe |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
-6.6 |
null |
0.1 |
0.26 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109098 |
3108 |
GK/Jpe |
plasma malondialdehyde level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood malondialdehyde amount |
male |
540 days
| 7 |
1.11 |
umol/l |
0.1 |
0.26 |
high-performance liquid chromatography |
0.0 |
0 |
|
110925 |
3193 |
GK/Jpe |
serum alkaline phosphatase activity level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood alkaline phosphatase amount |
male |
540 days
| 7 |
125.2 |
U/l |
7.4 |
19.58 |
blood enzyme activity assay |
0.0 |
0 |
|
110910 |
3193 |
GK/Jpe |
hepatic extraction fraction |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
xenobiotic pharmacokinetics trait |
male |
540 days
| 7 |
97.8 |
% |
1.74 |
4.6 |
scintigraphy |
0.0 |
0 |
|
110920 |
3193 |
GK/Jpe |
liver weight |
controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and lipoic acid (50 mg/kg) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
liver mass |
male |
540 days
| 7 |
6.37 |
g |
0.8 |
2.12 |
post excision weight measurement |
0.0 |
0 |
|
110854 |
3193 |
GK/Jpe |
serum total bilirubin level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood bilirubin amount |
male |
540 days
| 7 |
0.18 |
mg/dl |
0.02 |
0.05 |
ex vivo blood analysis |
0.0 |
0 |
|
110894 |
3193 |
GK/Jpe |
blood glucose level |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
blood glucose amount |
male |
540 days
| 10 |
365.6 |
mg/dl |
9.5 |
30.04 |
intraperitoneal glucose tolerance test |
0.0 |
120 |
min |
108013 |
3108 |
GK/Jpe |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) |
Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. |
vasodilation trait |
male |
540 days
| 7 |
99.5 |
% |
0.05 |
0.13 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
109113 |
3108 |
GK/Jpe |
serum aspartate aminotransferase activity level to alanine aminotransferase activity level ratio |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood aspartate transaminase amount |
male |
540 days
| 7 |
3.9 |
null |
0.2 |
0.53 |
blood enzyme activity assay |
0.0 |
0 |
|
110940 |
3193 |
GK/Jpe |
serum alanine aminotransferase activity level |
controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) |
Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. |
blood alanine transaminase amount |
male |
540 days
| 7 |
37.5 |
U/l |
1.3 |
3.44 |
blood enzyme activity assay |
0.0 |
0 |
|
110904 |
3193 |