SD |
retinal uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina blood vessel morphology trait |
male |
35 days-49 days |
3 |
180.0 |
% |
12.0 |
20.78 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106116 |
3028 |
SD |
aqueous humor uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and quinidine (10 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
aqueous humor morphology trait |
male |
35 days-49 days |
3 |
11.7 |
% |
0.6 |
1.04 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106133 |
3028 |
SD |
aqueous humor uptake index of digoxin |
tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
aqueous humor morphology trait |
male |
35 days-49 days |
3 |
17.5 |
% |
5.8 |
10.05 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106135 |
3028 |
SD |
brain uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and quinidine (10 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
blood-brain barrier morphology trait |
male |
35 days-49 days |
3 |
18.2 |
% |
1.2 |
2.08 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106151 |
3028 |
SD-Abcb1aem1Sage-/- |
brain uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
blood-brain barrier morphology trait |
male |
42 days-56 days |
3 |
12.4 |
% |
1.7 |
2.94 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106161 |
3028 |
SD |
retinal uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina blood vessel morphology trait |
male |
35 days-49 days |
3 |
212.0 |
% |
13.0 |
22.52 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106114 |
3028 |
SD-Abcb1aem1Sage-/- |
retinal uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina blood vessel morphology trait |
male |
42 days-56 days |
3 |
227.0 |
% |
25.0 |
43.3 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106123 |
3028 |
SD-Abcb1aem1Sage-/- |
retinal uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and quinidine (10 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina blood vessel morphology trait |
male |
42 days-56 days |
3 |
182.0 |
% |
24.0 |
41.57 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106124 |
3028 |
SD-Abcb1aem1Sage-/- |
retinal uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina blood vessel morphology trait |
male |
42 days-56 days |
3 |
142.0 |
% |
5.0 |
8.66 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106125 |
3028 |
SD |
aqueous humor uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
aqueous humor morphology trait |
male |
35 days-49 days |
3 |
5.95 |
% |
0.38 |
0.66 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106132 |
3028 |
SD-Abcb1aem1Sage-/- |
aqueous humor uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
aqueous humor morphology trait |
male |
42 days-56 days |
3 |
12.0 |
% |
0.6 |
1.04 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106141 |
3028 |
SD-Abcb1aem1Sage-/- |
aqueous humor uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
aqueous humor morphology trait |
male |
35 days-49 days |
3 |
8.83 |
% |
0.4 |
0.69 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106143 |
3028 |
SD-Abcb1aem1Sage-/- |
aqueous humor uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and quinidine (10 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
aqueous humor morphology trait |
male |
35 days-49 days |
3 |
12.5 |
% |
0.7 |
1.21 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106142 |
3028 |
SD-Abcb1aem1Sage-/- |
brain uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and quinidine (10 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
blood-brain barrier morphology trait |
male |
42 days-56 days |
3 |
21.6 |
% |
0.6 |
1.04 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106160 |
3028 |
SD |
brain uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
blood-brain barrier morphology trait |
male |
35 days-49 days |
3 |
13.2 |
% |
3.2 |
5.54 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106152 |
3028 |
SD |
retinal uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and quinidine (10 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina blood vessel morphology trait |
male |
35 days-49 days |
3 |
187.0 |
% |
22.0 |
38.11 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106115 |
3028 |
SD |
aqueous humor uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
aqueous humor morphology trait |
male |
35 days-49 days |
3 |
14.2 |
% |
3.5 |
6.06 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106134 |
3028 |
SD |
brain uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
blood-brain barrier morphology trait |
male |
35 days-49 days |
3 |
2.12 |
% |
0.12 |
0.21 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106150 |
3028 |
SD-Abcb1aem1Sage-/- |
brain uptake index of quinidine |
tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
blood-brain barrier morphology trait |
male |
42 days-56 days |
3 |
26.1 |
% |
2.4 |
4.16 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
quinidine uptake index |
106159 |
3028 |