LH/Mav |
both kidneys wet weight to body weight ratio |
controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) |
Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. |
kidney mass |
male |
119 days
| 6 |
7.22 |
g/kg |
0.34 |
0.83 |
post excision weight measurement |
0.0 |
0 |
103422 |
2824 |
SHR/N-cp |
both kidneys wet weight to body weight ratio |
standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then controlled hydralazine content drinking water (30 mg/l) (between 84 and 98 days) and hydralazine (50 mg/l) (between 84 and 98 days) and reserpine (4 mg/l) (between 84 and 98 days) |
Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. |
kidney mass |
male |
140 days-168 days |
8 |
1.83 |
g/kg |
0.31 |
0.88 |
post excision weight measurement |
0.0 |
0 |
101525 |
2601 |
LH/Mav |
aorta weight to body weight ratio |
controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) |
Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. |
aorta mass |
male |
119 days
| 6 |
15.7 |
mg/100g |
0.8 |
1.96 |
post excision weight measurement |
0.0 |
0 |
103417 |
2824 |
LH/Mav |
aorta weight to body weight ratio |
controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) |
Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. |
aorta mass |
male |
119 days
| 7 |
15.8 |
mg/100g |
0.8 |
2.12 |
post excision weight measurement |
0.0 |
0 |
103418 |
2824 |
LH/Mav |
both kidneys wet weight to body weight ratio |
streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) |
Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. |
kidney mass |
male |
112 days
| 7 |
8.05 |
g/kg |
0.24 |
0.63 |
post excision weight measurement |
0.0 |
0 |
102697 |
2703 |
LH/Mav |
heart left ventricle weight to body weight ratio |
controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) |
Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. |
heart left ventricle mass |
male |
119 days
| 7 |
2.79 |
mg/g |
0.04 |
0.11 |
post excision weight measurement |
0.0 |
0 |
103413 |
2824 |
LH/Mav |
heart left ventricle weight to body weight ratio |
controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) |
Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. |
heart left ventricle mass |
male |
119 days
| 6 |
2.88 |
mg/g |
0.06 |
0.15 |
post excision weight measurement |
0.0 |
0 |
103412 |
2824 |
LH/Mav |
both kidneys wet weight to body weight ratio |
controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days) |
Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b. |
kidney mass |
male |
119 days
| 7 |
7.3 |
g/kg |
0.09 |
0.24 |
post excision weight measurement |
0.0 |
0 |
103423 |
2824 |
LH/Mav |
aorta weight to body weight ratio |
streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) |
Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. |
aorta mass |
male |
112 days
| 7 |
12.5 |
mg/100g |
0.5 |
1.32 |
post excision weight measurement |
0.0 |
0 |
102691 |
2703 |
LH/Mav |
heart left ventricle weight to body weight ratio |
streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days) |
Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. |
heart left ventricle mass |
male |
112 days
| 7 |
24.2 |
mg/g |
0.3 |
0.79 |
post excision weight measurement |
0.0 |
0 |
102685 |
2703 |