Phenominer Database Results (84 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Value Units SEM SD Method Method Duration Post Insult Time Value Post Insult Time Unit Record ID Study ID
GK/Jpe blood glucose level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) then fasting (for 15 hours) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood glucose amount male 540 days 10 122.3 mg/dl 9.3 29.41 blood glucose test strip read by electrochemical glucometer 0.0 0 108008 3108
GK/Jpe blood glucose level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood glucose amount male 540 days 10 365.6 mg/dl 9.5 30.04 intraperitoneal glucose tolerance test 0.0 120 min 108013 3108
GK/Jpe plasma free fatty acids level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood free fatty acid amount male 540 days 10 0.89 mmol/l 0.06 0.19 enzymatic lipid assay 0.0 0 108018 3108
GK/Jpe acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 49.0 % 3.2 8.47 tissue force analysis utilizing a force transducer 0.0 0 109101 3108
GK/Jpe serum triglyceride level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood triglyceride amount male 540 days 7 196.46 mg/dl 37.17 98.34 colorimetry 0.0 0 110883 3193
GK/Jpe serum albumin level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood albumin amount male 540 days 7 2.6 g/dl 0.04 0.11 blood protein analysis 0.0 0 110887 3193
GK/Jpe blood glucose level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood glucose amount male 540 days 7 122.04 mg/dl 5.4 14.29 blood glucose test strip read by electrochemical glucometer 0.0 0 110864 3193
GK/Jpe hepatic extraction fraction controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. xenobiotic pharmacokinetics trait male 540 days 7 87.0 % 2.9 7.67 scintigraphy 0.0 0 110918 3193
GK/Jpe plasma malondialdehyde level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood malondialdehyde amount male 540 days 7 1.11 umol/l 0.1 0.26 high-performance liquid chromatography 0.0 0 110925 3193
GK/Jpe serum aspartate aminotransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood aspartate transaminase amount male 540 days 7 154.0 U/l 12.4 32.81 blood enzyme activity assay 0.0 0 110898 3193
GK/Jpe serum alanine aminotransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood alanine transaminase amount male 540 days 7 27.0 U/l 2.0 5.29 blood enzyme activity assay 0.0 0 110903 3193
GK/Jpe serum gamma-glutamyltransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood gamma-glutamyltransferase amount male 540 days 7 1.6 U/l 0.2 0.53 blood enzyme activity assay 0.0 0 110914 3193
GK/Jpe serum aspartate aminotransferase activity level to alanine aminotransferase activity level ratio controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood aspartate transaminase amount male 540 days 7 3.9 null 0.2 0.53 blood enzyme activity assay 0.0 0 110940 3193
GK/Jpe serum aspartate aminotransferase activity level to alanine aminotransferase activity level ratio controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood aspartate transaminase amount male 540 days 7 4.2 null 0.2 0.53 blood enzyme activity assay 0.0 0 110937 3193
GK/Jpe sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 99.5 % 0.05 0.13 tissue force analysis utilizing a force transducer 0.0 0 109113 3108
GK/Jpe serum total cholesterol level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood cholesterol amount male 540 days 7 705.4 mg/dl 118.15 312.59 colorimetry 0.0 0 110872 3193
GK/Jpe logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.47 null 0.03 0.08 tissue force analysis utilizing a force transducer 0.0 0 109107 3108
GK/Jpe serum alanine aminotransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood alanine transaminase amount male 540 days 7 40.1 U/l 4.3 11.38 blood enzyme activity assay 0.0 0 110902 3193
GK/Jpe serum alanine aminotransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood alanine transaminase amount male 540 days 7 37.5 U/l 1.3 3.44 blood enzyme activity assay 0.0 0 110904 3193
GK/Jpe serum alkaline phosphatase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood alkaline phosphatase amount male 540 days 7 157.3 U/l 9.8 25.93 blood enzyme activity assay 0.0 0 110908 3193
GK/Jpe logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.23 null 0.23 0.61 tissue force analysis utilizing a force transducer 0.0 0 109097 3108
GK/Jpe serum albumin level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood albumin amount male 540 days 7 2.4 g/dl 0.04 0.11 blood protein analysis 0.0 0 110889 3193
GK/Jpe blood glucose level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood glucose amount male 540 days 7 151.56 mg/dl 7.2 19.05 blood glucose test strip read by electrochemical glucometer 0.0 0 110862 3193
GK/Jpe urine albumin excretion rate controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. urine albumin amount male 540 days 10 35.7 mg/d 4.1 12.97 urine albumin analysis 0.0 0 108021 3108
GK/Jpe hepatic extraction fraction controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. xenobiotic pharmacokinetics trait male 540 days 7 94.6 % 1.8 4.76 scintigraphy 0.0 0 110919 3193
GK/Jpe serum aspartate aminotransferase activity level to alanine aminotransferase activity level ratio controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood aspartate transaminase amount male 540 days 7 5.7 null 0.4 1.06 blood enzyme activity assay 0.0 0 110938 3193
GK/Jpe liver weight controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. liver mass male 540 days 7 8.32 g 0.6 1.59 post excision weight measurement 0.0 0 110853 3193
GK/Jpe serum total cholesterol level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood cholesterol amount male 540 days 7 92.28 mg/dl 10.42 27.58 colorimetry 0.0 0 110874 3193
GK/Jpe blood glucose level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood glucose amount male 540 days 7 358.2 mg/dl 14.4 38.1 intraperitoneal glucose tolerance test 0.0 0 110868 3193
GK/Jpe serum non-high density lipoprotein cholesterol level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood cholesterol amount male 540 days 7 1.11 mmol/l 0.16 0.42 colorimetry 0.0 0 110879 3193
GK/Jpe liver weight to body weight ratio controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and lipoic acid (50 mg/kg) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. liver mass male 540 days 7 16.3 g/kg 1.9 5.03 post excision weight measurement 0.0 0 110859 3193
GK/Jpe body weight gain controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. body mass male 450 days-540 days 10 50.1 g 6.4 20.24 body weighing method 0.0 0 108002 3108
GK/Jpe blood glucose level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 g/kg) (for 90 days) then soybean oil (2 ml/kg) then fasting (2 ml/kg) (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood glucose amount male 540 days 10 338.6 mg/dl 23.4 74.0 intraperitoneal glucose tolerance test 0.0 120 min 108012 3108
GK/Jpe plasma free fatty acids level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood free fatty acid amount male 540 days 10 0.9 mmol/l 0.12 0.38 enzymatic lipid assay 0.0 0 108017 3108
GK/Jpe sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 99.5 % 0.11 0.29 tissue force analysis utilizing a force transducer 0.0 0 109112 3108
GK/Jpe serum triglyceride level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood triglyceride amount male 540 days 7 551.33 mg/dl 84.96 224.77 colorimetry 0.0 0 110882 3193
GK/Jpe serum triglyceride level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood triglyceride amount male 540 days 7 116.81 mg/dl 14.16 37.46 colorimetry 0.0 0 110884 3193
GK/Jpe serum albumin level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood albumin amount male 540 days 7 2.7 g/dl 0.06 0.16 blood protein analysis 0.0 0 110888 3193
GK/Jpe serum total bilirubin level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood bilirubin amount male 540 days 7 0.14 mg/dl 0.04 0.11 ex vivo blood analysis 0.0 0 110893 3193
GK/Jpe blood glucose level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood glucose amount male 540 days 7 129.42 mg/dl 5.4 14.29 blood glucose test strip read by electrochemical glucometer 0.0 0 110863 3193
GK/Jpe urine 8-hydroxy-2'-deoxyguanosine level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. urine molecular composition trait male 540 days 7 415.8 ng/d 74.29 196.55 enzyme linked immunosorbent assay 0.0 0 110928 3193
GK/Jpe serum uric acid level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood uric acid amount male 540 days 7 0.03 umol/l 0.0 0.01 blood uric acid analysis 0.0 0 110934 3193
GK/Jpe body weight controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. body mass male 540 days 7 428.8 g 12.0 31.75 body weighing method 0.0 0 110848 3193
GK/Jpe liver weight to body weight ratio controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. liver mass male 540 days 7 27.1 g/kg 0.7 1.85 post excision weight measurement 0.0 0 110857 3193
GK/Jpe serum total bilirubin level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood bilirubin amount male 540 days 7 0.14 mg/dl 0.02 0.05 ex vivo blood analysis 0.0 0 110892 3193
GK/Jpe blood glucose level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then fasting (between 15 and 0.2 hours) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood glucose amount male 540 days 10 151.7 mg/dl 7.9 24.98 blood glucose test strip read by electrochemical glucometer 0.0 0 108006 3108
GK/Jpe liver weight to body weight ratio controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. liver mass male 540 days 7 19.1 g/kg 1.1 2.91 post excision weight measurement 0.0 0 110858 3193
GK/Jpe urine 8-hydroxy-2'-deoxyguanosine level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. urine molecular composition trait male 540 days 7 302.37 ng/d 42.34 112.02 enzyme linked immunosorbent assay 0.0 0 110929 3193
GK/Jpe logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.4 null 0.02 0.04 tissue force analysis utilizing a force transducer 0.0 0 109106 3108
GK/Jpe sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 99.5 % 0.15 0.4 tissue force analysis utilizing a force transducer 0.0 0 109111 3108
GK/Jpe liver weight controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. liver mass male 540 days 7 11.05 g 0.2 0.53 post excision weight measurement 0.0 0 110852 3193
GK/Jpe liver weight controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and lipoic acid (50 mg/kg) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. liver mass male 540 days 7 6.37 g 0.8 2.12 post excision weight measurement 0.0 0 110854 3193
GK/Jpe serum total cholesterol level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood cholesterol amount male 540 days 7 145.56 mg/dl 21.62 57.21 colorimetry 0.0 0 110873 3193
GK/Jpe blood glucose level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood glucose amount male 540 days 7 418.68 mg/dl 28.8 76.2 intraperitoneal glucose tolerance test 0.0 0 110867 3193
GK/Jpe serum alkaline phosphatase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood alkaline phosphatase amount male 540 days 7 114.8 U/l 7.8 20.64 blood enzyme activity assay 0.0 0 110909 3193
GK/Jpe serum non-high density lipoprotein cholesterol level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood cholesterol amount male 540 days 7 2.23 mmol/l 0.48 1.27 colorimetry 0.0 0 110878 3193
GK/Jpe serum gamma-glutamyltransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood gamma-glutamyltransferase amount male 540 days 7 1.3 U/l 0.2 0.53 blood enzyme activity assay 0.0 0 110915 3193
GK/Jpe serum aspartate aminotransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood aspartate transaminase amount male 540 days 7 151.0 U/l 8.7 23.02 blood enzyme activity assay 0.0 0 110899 3193
GK/Jpe serum alkaline phosphatase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood alkaline phosphatase amount male 540 days 7 125.2 U/l 7.4 19.58 blood enzyme activity assay 0.0 0 110910 3193
GK/Jpe body weight gain controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. body mass male 450 days-540 days 10 7.6 g 2.6 8.22 body weighing method 0.0 0 108001 3108
GK/Jpe body weight gain controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. body mass male 450 days-540 days 10 11.9 g 3.7 11.7 body weighing method 0.0 0 108003 3108
GK/Jpe blood glucose level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) then fasting (for 15 hours) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood glucose amount male 540 days 10 129.6 mg/dl 4.5 14.23 blood glucose test strip read by electrochemical glucometer 0.0 0 108007 3108
GK/Jpe blood glucose level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood glucose amount male 540 days 10 419.1 mg/dl 28.5 90.12 intraperitoneal glucose tolerance test 0.0 120 min 108011 3108
GK/Jpe plasma free fatty acids level controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. blood free fatty acid amount male 540 days 10 0.69 mmol/l 0.09 0.28 enzymatic lipid assay 0.0 0 108016 3108
GK/Jpe urine albumin excretion rate controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. urine albumin amount male 540 days 10 30.9 mg/d 2.8 8.85 urine albumin analysis 0.0 0 108022 3108
GK/Jpe urine albumin excretion rate controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. urine albumin amount male 540 days 10 17.8 mg/d 2.9 9.17 urine albumin analysis 0.0 0 108023 3108
GK/Jpe logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.16 null 0.07 0.19 tissue force analysis utilizing a force transducer 0.0 0 109096 3108
GK/Jpe logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.6 null 0.1 0.26 tissue force analysis utilizing a force transducer 0.0 0 109098 3108
GK/Jpe body weight controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. body mass male 540 days 7 410.9 g 5.1 13.49 body weighing method 0.0 0 110861 3193
GK/Jpe plasma malondialdehyde level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood malondialdehyde amount male 540 days 7 1.8 umol/l 0.1 0.26 high-performance liquid chromatography 0.0 0 110923 3193
GK/Jpe plasma malondialdehyde level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and soybean oil (2 ml/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood malondialdehyde amount male 540 days 7 1.42 umol/l 0.2 0.53 high-performance liquid chromatography 0.0 0 110924 3193
GK/Jpe urine 8-hydroxy-2'-deoxyguanosine level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. urine molecular composition trait male 540 days 7 5.63 ng/d 0.36 0.95 enzyme linked immunosorbent assay 0.0 0 110930 3193
GK/Jpe hepatic extraction fraction controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. xenobiotic pharmacokinetics trait male 540 days 7 97.8 % 1.74 4.6 scintigraphy 0.0 0 110920 3193
GK/Jpe serum uric acid level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood uric acid amount male 540 days 7 0.03 umol/l 0.0 0.01 blood uric acid analysis 0.0 0 110933 3193
GK/Jpe serum uric acid level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood uric acid amount male 540 days 7 0.02 umol/l 0.0 0.0 blood uric acid analysis 0.0 0 110935 3193
GK/Jpe acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 70.0 % 2.1 5.56 tissue force analysis utilizing a force transducer 0.0 0 109103 3108
GK/Jpe logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then lipoic acid (50 mg/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 -6.25 null 0.07 0.19 tissue force analysis utilizing a force transducer 0.0 0 109108 3108
GK/Jpe body weight controlled cocoa butter content diet (7.5 null) (for 90 days) and controlled cholesterol content diet (1.25 null) (for 90 days) and lipoic acid (50 mg/kg) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. body mass male 540 days 7 433.9 g 10.9 28.84 body weighing method 0.0 0 110849 3193
GK/Jpe serum total bilirubin level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood bilirubin amount male 540 days 7 0.18 mg/dl 0.02 0.05 ex vivo blood analysis 0.0 0 110894 3193
GK/Jpe serum gamma-glutamyltransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood gamma-glutamyltransferase amount male 540 days 7 1.9 U/l 0.1 0.26 blood enzyme activity assay 0.0 0 110913 3193
GK/Jpe acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled cholesterol content diet (1.25 %) (for 90 days) and controlled cocoa butter content diet (7.5 %) (for 90 days) then soybean oil (2 ml/kg) (for 90 days) Sena CM, etal., Br J Pharmacol. 2008 Mar;153(5):894-906. doi: 10.1038/sj.bjp.0707474. Epub 2007 Oct 1. vasodilation trait male 540 days 7 55.0 % 2.5 6.61 tissue force analysis utilizing a force transducer 0.0 0 109102 3108
GK/Jpe blood glucose level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) and lipoic acid (50 mg/kg) then fasting (for 15 hours) then glucose solution (1.75 g/kg) (for 2 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood glucose amount male 540 days 7 363.6 mg/dl 9.0 23.81 intraperitoneal glucose tolerance test 0.0 0 110869 3193
GK/Jpe serum total cholesterol level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood cholesterol amount male 540 days 7 618.15 mg/dl 115.83 306.46 colorimetry 0.0 0 110877 3193
GK/Jpe serum aspartate aminotransferase activity level controlled cocoa butter content diet (7.5 %) (for 90 days) and controlled cholesterol content diet (1.25 %) (for 90 days) then fasting (for 15 hours) Sena CM, etal., Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092706. doi: 10.3390/ijms19092706. blood aspartate transaminase amount male 540 days 7 176.0 U/l 7.4 19.58 blood enzyme activity assay 0.0 0 110897 3193