Phenominer Database Results (128 results)

 

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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Record ID Study ID
GH/Omr single kidney wet weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132 days-146 days 21 3.4 g/kg 0.04 0.2 post excision weight measurement 0 ng/kg/min kidney wet weight to body weight ratio (CMO:0003389) 11526 101
GH/Omr body weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. body mass male 132 days-146 days 21 365.4 g 3.71 17.0 body weighing method 0 11527 101
BN/NHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 20 serial mean 27.0 mmHg 2.0 8.94 vascular indwelling catheter method left femoral artery 0.0 0 67299 151
BN.GH-(D6Mit12-D6Rat15)/Mcwi body weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. body mass male 132 days-146 days 16 299.9 g 6.0 24.0 body weighing method 0 11541 101
BN.GH-(D18Rat41-D18Mgh4)/Mcwi single kidney wet weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132 days-146 days 21 3.8 g/kg 0.09 0.4 post excision weight measurement 0 ng/kg/min kidney wet weight to body weight ratio (CMO:0003389) 11547 101
BN/Elh body weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. body mass male 132 days-146 days 21 310.3 g 7.64 35.0 body weighing method 0 11555 101
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (20 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 20 serial mean 118.9 mmHg 4.4 19.68 vascular indwelling catheter method left femoral artery 120.0 0 69529 151
SS/JrHsdMcwi middle cerebral artery inner diameter angiotensin II (3 ng/kg/min) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63 days-98 days 5 246.0 um 3.7 8.27 ex vivo videomicroscopy 0.0 0 69577 732
WKY/Izm absolute change in mean arterial blood pressure candesartan (1 ug) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) then phenylephrine (3 ug) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 53.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 84571 1120
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure vehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) then phenylephrine (3 ug) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 50.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 84572 1120
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure candesartan (1 ug) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) then phenylephrine (3 ug) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 56.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84573 1120
BN/Elh heart left ventricle wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132 days-146 days 21 1.15 g 0.03 0.13 post excision weight measurement 0.0 0 ng/kg/min 68333 101
GH/Omr heart left ventricle weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132 days-146 days 21 4.7 mg/g 0.15 0.7 post excision weight measurement 0.0 0 ng/kg/min Original CMO ID was CMO:0000540. Corrected 2-15-2018. 68334 101
BN.GH-(D2Rat22-D2Mgh11)/Mcwi heart left ventricle weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132 days-146 days 19 3.4 mg/g 0.11 0.5 post excision weight measurement 0.0 0 ng/kg/min Original CMO ID was CMO:0000540. Corrected 2-15-2018. 68335 101
BN.GH-(D6Mit12-D6Rat15)/Mcwi heart left ventricle weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132 days-146 days 16 3.8 mg/g 0.08 0.3 post excision weight measurement 0.0 0 ng/kg/min Original CMO ID was CMO:0000540. Corrected 2-15-2018. 68336 101
GH/Omr change in mean arterial blood pressure to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 130 days-144 days 14 0.48 mmHg/ng/kg/min 0.02 0.08 vascular indwelling catheter method left femoral artery and vein 0.0 0 microrenathane catheter; recover for 1 week after surgery slope of map response curve 68339 101
SS/JrHsdMcwi middle cerebral artery inner diameter angiotensin II (3 ng/kg/min) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63 days-98 days 5 247.0 um 7.8 17.44 ex vivo videomicroscopy 0.0 0 69574 732
SD-Nfe2l2em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then angiotensin II (100 ng/kg/min) (for 3 days) Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. arterial blood pressure trait male 9 days-11 days 3 95.0 mmHg 4.3 7.45 vascular fluid filled catheter 0.0 0 100741 2520
SS-Adora2bem2Mcwi heart left ventricle end-diastolic anterior wall thickness angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle anterior wall thickness male 77 days-84 days 7 1.97 mm 0.12 0.32 transthoracic echocardiography 0.0 0 105813 3023
SS-Adora2bem2Mcwi heart left ventricle end-diastolic diameter angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle end-diastolic diameter male 63 days-70 days 7 6.73 mm 0.18 0.48 transthoracic echocardiography 0.0 0 should be inner diameter 105823 3023
SS/JrHsdMcwi heart rate angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart pumping trait male 63 days-70 days 5 394.0 beats/min 6.0 13.42 transthoracic echocardiography 0.0 0 105834 3023
SS-Adora2bem2Mcwi heart rate angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart pumping trait male 77 days-84 days 7 351.0 beats/min 14.0 37.04 transthoracic echocardiography 0.0 0 105837 3023
SS/JrHsdMcwi tibia length angiotensin II (200 ng/kg/min) (for 28 days) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. tibia length male 77 days-84 days 6 3.96 cm 0.03 0.07 post excision length measurement 0.0 0 105856 3023
WKY/NCrl absolute change in mean arterial blood pressure artificial cerebrospinal fluid (200 nl) then angiotensin II (90 ng) then candesartan (0.5 ug) (for 0.2 hours) then angiotensin II (90 ng) Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. arterial blood pressure trait not specified 0 days 4 1.0 mmHg 1.0 2.0 vascular fluid filled catheter 0.0 0 110106 2685
BN.GH-(D18Rat41-D18Mgh4)/Mcwi change in heart rate to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart pumping trait male 132 days-146 days 11 -1.25 (beats/min)/(ug/kg) 0.05 0.17 vascular indwelling catheter method 0.0 0 ng/kg/min change in heart rate to change in vasoactive chemical dose ratio (CMO:0003904), (beats/min)/(ug/kg) 138469 101
BN.GH-(D2Rat22-D2Mgh11)/Mcwi kidney wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132 days-146 days 19 1.15 g 0.03 0.15 post excision weight measurement 0 ng/kg/min 11532 101
BN.GH-(D6Mit12-D6Rat15)/Mcwi single kidney wet weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132 days-146 days 16 3.7 g/kg 0.1 0.4 post excision weight measurement 0 ng/kg/min kidney wet weight to body weight ratio (CMO:0003389) 11540 101
SS.MNS-(D2Mit6-D2Rat303)/Ayd receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 13 26.63 % 4.0 14.42 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69070 1096
SS/JrHsdMcwi middle cerebral artery inner diameter angiotensin II (3 ng/kg/min) (for 3 days) then physiological salt solution perfusate then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63 days-98 days 5 113.0 um 4.2 9.39 ex vivo videomicroscopy 0.0 0 69576 732
SS/JrHsdMcwi body weight common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) then angiotensin II (3 ng/kg/min) (for 7 days) then controlled losartan content drinking water (50 mg/kg/d) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. body mass male 56 days-70 days 3 282.8 g 2.9 5.02 body weighing method 0.0 0 99016 2198
SS/JrHsdMcwi percent change in middle cerebral artery inner diameter angiotensin II (3 ng/kg/min) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63 days-98 days 5 [(max dia - baseline dia) /max dia] x 100 37.0 % 1.5 3.35 ex vivo videomicroscopy 0.0 0 69575 732
WKY/Izm absolute change in mean arterial blood pressure candesartan (1 ug) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 0.0 mmHg 1.0 2.45 vascular indwelling catheter method 0.0 0 84567 1120
BN.GH-(D18Rat41-D18Mgh4)/Mcwi body weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. body mass male 132 days-146 days 21 315.2 g 5.24 24.0 body weighing method 0 11548 101
BN/Elh kidney wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132 days-146 days 21 1.12 g 0.02 0.1 post excision weight measurement 0 ng/kg/min 11553 101
SD-Nfe2l2em1Mcwi-/- body weight controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then angiotensin II (100 ng/kg/min) (for 3 days) Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. body mass male 9 days-11 days 6 307.0 g 11.5 28.17 body weighing method 0.0 0 100736 2520
SS/JrHsdMcwi heart left ventricle end-diastolic anterior wall thickness angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle anterior wall thickness male 77 days-84 days 5 2.13 mm 0.09 0.2 transthoracic echocardiography 0.0 0 105812 3023
SS/JrHsdMcwi heart left ventricle end-diastolic posterior wall thickness angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle posterior wall thickness male 63 days-70 days 5 2.17 mm 0.11 0.25 transthoracic echocardiography 0.0 0 105816 3023
SS/JrHsdMcwi heart left ventricle end-diastolic posterior wall thickness angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle posterior wall thickness male 77 days-84 days 5 1.94 mm 0.18 0.4 transthoracic echocardiography 0.0 0 105818 3023
SS/JrHsdMcwi heart left ventricle fractional shortening angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle end-diastolic diameter male 77 days-84 days 5 51.9 % 3.7 8.27 transthoracic echocardiography 0.0 0 105830 3023
SS-Adora2bem2Mcwi heart left ventricle fractional shortening angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle end-diastolic diameter male 77 days-84 days 7 48.2 % 3.5 9.26 transthoracic echocardiography 0.0 0 105831 3023
SS-Adora2bem2Mcwi stroke volume angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. blood flow trait male 63 days-70 days 7 0.19 ml 0.01 0.03 transthoracic echocardiography 0.0 0 105841 3023
SS/JrHsdMcwi stroke volume angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. blood flow trait male 77 days-84 days 5 0.22 ml 0.02 0.05 transthoracic echocardiography 0.0 0 105842 3023
SS-Adora2bem2Mcwi cardiac output angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. cardiac output trait male 63 days-70 days 7 68.0 ml/min 5.0 13.23 transthoracic echocardiography 0.0 0 105847 3023
WKY/NCrl absolute change in heart rate artificial cerebrospinal fluid (200 nl) then angiotensin II (90 ng) then candesartan (0.5 ug) (for 0.2 hours) then angiotensin II (90 ng) Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. heart pumping trait not specified 0 days 4 11.0 beats/min 7.0 14.0 vascular fluid filled catheter 0.0 0 110137 2685
BN.GH-(D6Mit12-D6Rat15)/Mcwi heart left ventricle wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132 days-146 days 16 1.17 g 0.06 0.23 post excision weight measurement 0.0 0 ng/kg/min 68331 101
SS/Jr logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 -8.22 null 0.26 0.9 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69067 1096
SS/JrHsdMcwi percent change in middle cerebral artery inner diameter angiotensin II (3 ng/kg/min) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63 days-98 days 5 54.0 % 2.2 4.92 ex vivo videomicroscopy 0.0 0 69578 732
SS/JrHsdMcwi body weight common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) then angiotensin II (3 ng/kg/min) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. body mass male 56 days-70 days 4 270.8 g 7.8 15.6 body weighing method 0.0 0 99014 2198
SS/JrHsdMcwi tibialis anterior muscle weight to body weight ratio control condition (for 7 days) then angiotensin II (3 ng/kg/min) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56 days-70 days 4 TA/BW 1.68 mg/g 0.04 0.08 ex vivo method 0.0 0 TA or EDL muscle weight body weight ratio 99051 2198
SD-Nfe2l2em1Mcwi-/- percent change in middle cerebral artery inner diameter controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then angiotensin II (100 ng/kg/min) (for 3 days) then physiological salt solution perfusate Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. cerebral artery size trait male 9 days-11 days 5 43.9 % 4.99 11.16 ex vivo method 0.0 0 tone 100760 2520
GH/Omr kidney wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132 days-146 days 21 1.22 g 0.01 0.05 post excision weight measurement 0 ng/kg/min 11525 101
BN.GH-(D2Rat22-D2Mgh11)/Mcwi body weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. body mass male 132 days-146 days 19 330.6 g 5.96 26.0 body weighing method 0 11534 101
BN.GH-(D6Mit12-D6Rat15)/Mcwi kidney wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132 days-146 days 16 1.12 g 0.05 0.2 post excision weight measurement 0 ng/kg/min 11539 101
SS/JrHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 34.0 mmHg 3.0 10.82 vascular indwelling catheter method left femoral artery 0.0 0 67300 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (20 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 131.3 mmHg 4.2 15.14 vascular indwelling catheter method left femoral artery 120.0 0 69530 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (100 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 132.9 mmHg 3.8 17.41 vascular indwelling catheter method left femoral artery 120.0 0 69531 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 160.2 mmHg 3.5 12.62 vascular indwelling catheter method left femoral artery 120.0 0 69534 151
BN.GH-(D18Rat41-D18Mgh4)/Mcwi heart left ventricle wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132 days-146 days 21 1.15 g 0.04 0.2 post excision weight measurement 0.0 0 ng/kg/min 68332 101
BN/Elh heart left ventricle weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132 days-146 days 21 3.7 mg/g 0.13 0.6 post excision weight measurement 0.0 0 ng/kg/min Original CMO ID was CMO:0000540. Corrected 2-15-2018. 68338 101
BN.GH-(D2Rat22-D2Mgh11)/Mcwi change in mean arterial blood pressure to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 130 days-144 days 11 0.66 mmHg/ng/kg/min 0.03 0.09 vascular indwelling catheter method left femoral artery and vein 0.0 0 microrenathane catheter; recover for 1 week after surgery slope of map response curve 68340 101
SS/JrHsdMcwi middle cerebral artery inner diameter angiotensin II (3 ng/kg/min) (for 3 days) then physiological salt solution perfusate Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63 days-98 days 6 157.0 um 2.0 4.9 ex vivo videomicroscopy 0.0 0 69573 732
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure candesartan (1 ug) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 -1.0 mmHg 4.0 9.8 vascular indwelling catheter method 0.0 0 84569 1120
SS/JrHsdMcwi extensor digitorum longus muscle weight to body weight ratio control condition (for 7 days) then angiotensin II (3 ng/kg/min) (for 7 days) then controlled losartan content drinking water (50 mg/kg/d) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56 days-70 days 3 EDL/BW 0.43 mg/g 0.01 0.02 ex vivo method 0.0 0 TA or EDL muscle weight body weight ratio 99053 2198
SS/JrHsdMcwi heart left ventricle end-diastolic anterior wall thickness angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle anterior wall thickness male 63 days-70 days 5 2.19 mm 0.21 0.47 transthoracic echocardiography 0.0 0 105810 3023
SS-Adora2bem2Mcwi heart left ventricle end-diastolic posterior wall thickness angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle posterior wall thickness male 63 days-70 days 7 2.33 mm 0.08 0.21 transthoracic echocardiography 0.0 0 105817 3023
SS/JrHsdMcwi heart left ventricle fractional shortening angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle end-diastolic diameter male 63 days-70 days 5 57.2 % 2.7 6.04 transthoracic echocardiography 0.0 0 105828 3023
SS-Adora2bem2Mcwi heart rate angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart pumping trait male 63 days-70 days 7 360.0 beats/min 14.0 37.04 transthoracic echocardiography 0.0 0 105835 3023
SS/JrHsdMcwi stroke volume angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. blood flow trait male 63 days-70 days 5 0.2 ml 0.03 0.06 transthoracic echocardiography 0.0 0 105840 3023
SS/JrHsdMcwi cardiac output angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. cardiac output trait male 77 days-84 days 5 77.0 ml/min 6.0 13.42 transthoracic echocardiography 0.0 0 105848 3023
SS-Adora2bem2Mcwi cardiac output angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. cardiac output trait male 77 days-84 days 7 71.0 ml/min 7.0 18.52 transthoracic echocardiography 0.0 0 105849 3023
SS-Adora2bem2Mcwi single kidney weight to tibia length ratio angiotensin II (200 ng/kg/min) (for 28 days) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. kidney mass male 77 days-84 days 8 0.27 g/cm 0.01 0.03 post excision weight measurement 0.0 0 105853 3023
SS/JrHsdMcwi lung weight to tibia length ratio angiotensin II (200 ng/kg/min) (for 28 days) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. lung mass male 77 days-84 days 6 0.28 g/cm 0.01 0.02 post excision weight measurement 0.0 0 105854 3023
WKY/NCrl absolute change in mean arterial blood pressure artificial cerebrospinal fluid (200 nl) then angiotensin II (90 ng) Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. arterial blood pressure trait not specified 0 days 7 16.0 mmHg 2.0 5.29 vascular fluid filled catheter 0.0 0 110104 2685
WKY/NCrl absolute change in mean arterial blood pressure artificial cerebrospinal fluid (200 nl) then angiotensin II (90 ng) then candesartan (0.05 ug) (for 0.2 hours) then angiotensin II (90 ng) Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. arterial blood pressure trait not specified 0 days 3 10.0 mmHg 3.0 5.2 vascular fluid filled catheter 0.0 0 110105 2685
BN/Elh change in heart rate to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart pumping trait male 132 days-146 days 14 -2.28 (beats/min)/(ug/kg) 0.07 0.26 vascular indwelling catheter method 0.0 0 ng/kg/min change in heart rate to change in vasoactive chemical dose ratio (CMO:0003904), (beats/min)/(ug/kg) 138470 101
GH/Omr change in heart rate to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart pumping trait male 132 days-146 days 14 -0.87 (beats/min)/(ug/kg) 0.07 0.25 vascular indwelling catheter method 0.0 0 ng/kg/min change in heart rate to change in vasoactive chemical dose ratio (CMO:0003904), (beats/min)/(ug/kg) 138468 101
SS/JrHsdMcwi extensor digitorum longus muscle weight to body weight ratio common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) then angiotensin II (3 ng/kg/min) (for 7 days) then controlled losartan content drinking water (50 mg/kg/d) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56 days-70 days 3 EDL/BW 0.46 mg/g 0.01 0.02 ex vivo method 0.0 0 TA or EDL muscle weight body weight ratio 99054 2198
WKY/Izm absolute change in mean arterial blood pressure vehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) then phenylephrine (3 ug) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 50.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84570 1120
SD-Nfe2l2em1Mcwi+/+ percent change in middle cerebral artery inner diameter controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then angiotensin II (100 ng/kg/min) (for 3 days) then physiological salt solution perfusate Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. cerebral artery size trait male 9 days-11 days 4 47.3 % 4.48 8.96 ex vivo method 0.0 0 tone 100759 2520
GH/Omr heart left ventricle wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132 days-146 days 21 1.69 g 0.03 0.13 post excision weight measurement 0.0 0 ng/kg/min 68329 101
BN.GH-(D2Rat22-D2Mgh11)/Mcwi heart left ventricle wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132 days-146 days 19 1.13 g 0.03 0.15 post excision weight measurement 0.0 0 ng/kg/min 68330 101
BN.GH-(D18Rat41-D18Mgh4)/Mcwi change in mean arterial blood pressure to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 130 days-144 days 11 0.71 mmHg/ng/kg/min 0.02 0.07 vascular indwelling catheter method left femoral artery and vein 0.0 0 microrenathane catheter; recover for 1 week after surgery slope of map response curve 68342 101
SS/Jr receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 34.85 % 2.94 10.18 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69065 1096
SS.MNS-(D2Mit6-D2Rat303)/Ayd receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 13 19.33 % 3.67 13.23 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69066 1096
SS/Jr logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) then NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 -7.92 null 0.36 1.25 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69071 1096
SHRSP.WKY-(D1Wox29-D1Arb21)/Izm change in cell membrane potential angiotensin II (6 umol/l) (for 0.3 hours) Iigaya K, et al., Hypertension. 2008 Dec 1. action potential trait not specified 0 days-4 days 8 4.1 mV 0.81 2.3 whole-cell patch clamp technique 0 0 regularly firing neurons 65901 634
BN/NHsdMcwi ratio of change in renal blood flow rate to kidney weight controlled sodium content diet (0.4 %) (for 16 hours) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renal blood flow trait female 97 days-101 days 21 -1.4 ml/min/g 0.3 1.37 electromagnetic flowmetry 0.0 0 electromagnetic flowmetry change in renal blood flow rate 67305 151
BN.GH-(D18Rat41-D18Mgh4)/Mcwi kidney wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132 days-146 days 21 1.17 g 0.04 0.2 post excision weight measurement 0 ng/kg/min 11546 101
BN/Elh single kidney wet weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132 days-146 days 21 3.6 g/kg 0.09 0.4 post excision weight measurement 0 ng/kg/min kidney wet weight to body weight ratio (CMO:0003389) 11554 101
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (100 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 147.2 mmHg 3.9 14.06 vascular indwelling catheter method left femoral artery 120.0 0 69532 151
SD-Nfe2l2em1Mcwi-/- middle cerebral artery inner diameter controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then angiotensin II (100 ng/kg/min) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. cerebral artery size trait male 9 days-11 days 5 243.0 um 7.0 15.65 ex vivo method 0.0 0 max dilation 100748 2520
SD-Nfe2l2em1Mcwi-/- middle cerebral artery inner diameter controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then angiotensin II (100 ng/kg/min) (for 3 days) then physiological salt solution perfusate Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. cerebral artery size trait male 9 days-11 days 5 136.0 um 10.2 22.81 ex vivo method 0.0 0 resting diameter 100754 2520
SD-Nfe2l2em1Mcwi+/+ body weight controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then angiotensin II (100 ng/kg/min) (for 3 days) Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. body mass male 9 days-11 days 6 291.0 g 11.6 28.41 body weighing method 0.0 0 100735 2520
SS/JrHsdMcwi extensor digitorum longus muscle weight to body weight ratio common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) then angiotensin II (3 ng/kg/min) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56 days-70 days 4 EDL/BW 0.41 mg/g 0.02 0.04 ex vivo method 0.0 0 TA or EDL muscle weight body weight ratio 99050 2198
SS/JrHsdMcwi heart left ventricle end-diastolic diameter angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle end-diastolic diameter male 77 days-84 days 5 7.15 mm 0.34 0.76 transthoracic echocardiography 0.0 0 should be inner diameter 105824 3023
SS/JrHsdMcwi heart rate angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart pumping trait male 77 days-84 days 5 358.0 beats/min 17.0 38.01 transthoracic echocardiography 0.0 0 105836 3023
SS-Adora2bem2Mcwi stroke volume angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. blood flow trait male 77 days-84 days 7 0.2 ml 0.02 0.04 transthoracic echocardiography 0.0 0 105843 3023
SS/JrHsdMcwi cardiac output angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. cardiac output trait male 63 days-70 days 5 78.0 ml/min 10.0 22.36 transthoracic echocardiography 0.0 0 105846 3023
SS/JrHsdMcwi heart left ventricle weight to tibia length ratio angiotensin II (200 ng/kg/min) (for 28 days) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle mass male 77 days-84 days 6 0.19 g/cm 0.01 0.02 post excision weight measurement 0.0 0 105850 3023
SS/JrHsdMcwi single kidney weight to tibia length ratio angiotensin II (200 ng/kg/min) (for 28 days) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. kidney mass male 77 days-84 days 6 0.28 g/cm 0.01 0.02 post excision weight measurement 0.0 0 105852 3023
SS-Adora2bem2Mcwi lung weight to tibia length ratio angiotensin II (200 ng/kg/min) (for 28 days) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. lung mass male 77 days-84 days 8 0.28 g/cm 0.01 0.03 post excision weight measurement 0.0 0 105855 3023
SS-Adora2bem2Mcwi tibia length angiotensin II (200 ng/kg/min) (for 28 days) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. tibia length male 77 days-84 days 8 3.95 cm 0.02 0.06 post excision length measurement 0.0 0 105857 3023
WKY/NCrl absolute change in heart rate artificial cerebrospinal fluid (200 nl) then angiotensin II (90 ng) then candesartan (0.05 ug) (for 0.2 hours) then angiotensin II (90 ng) Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. heart pumping trait not specified 0 days 3 31.0 beats/min 11.0 19.05 vascular fluid filled catheter 0.0 0 110136 2685
BN.GH-(D18Rat41-D18Mgh4)/Mcwi heart left ventricle weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132 days-146 days 21 3.7 mg/g 0.07 0.3 post excision weight measurement 0.0 0 ng/kg/min Original CMO ID was CMO:0000540. Corrected 2-15-2018. 68337 101
BN.GH-(D6Mit12-D6Rat15)/Mcwi change in mean arterial blood pressure to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 130 days-144 days 11 0.86 mmHg/ng/kg/min 0.02 0.08 vascular indwelling catheter method left femoral artery and vein 0.0 0 microrenathane catheter; recover for 1 week after surgery slope of map response curve 68341 101
SS.MNS-(D2Mit6-D2Rat303)/Ayd logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 13 -7.2 null 0.31 1.12 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69072 1096
SS-Adora2bem2Mcwi heart left ventricle end-diastolic anterior wall thickness angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle anterior wall thickness male 63 days-70 days 7 1.91 mm 0.07 0.19 transthoracic echocardiography 0.0 0 105811 3023
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure vehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 32.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84568 1120
BN.GH-(D2Rat22-D2Mgh11)/Mcwi single kidney wet weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132 days-146 days 19 3.7 g/kg 0.07 0.3 post excision weight measurement 0.0 0 ng/kg/min kidney wet weight to body weight ratio (CMO:0003389) 11533 101
SS/JrHsdMcwi ratio of change in renal blood flow rate to kidney weight controlled sodium content diet (0.4 %) (for 16 hours) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renal blood flow trait female 97 days-101 days 13 -2.4 ml/min/g 0.5 1.8 electromagnetic flowmetry 0.0 0 electromagnetic flowmetry 67306 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 139.1 mmHg 3.6 16.5 vascular indwelling catheter method left femoral artery 120.0 0 69533 151
WKY/Izm absolute change in mean arterial blood pressure vehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 27.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 84566 1120
BN/Elh change in mean arterial blood pressure to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. arterial blood pressure trait male 130 days-144 days 14 0.88 mmHg/ng/kg/min 0.02 0.08 vascular indwelling catheter method left femoral artery and vein 0.0 0 microrenathane catheter; recover for 1 week after surgery slope of map response curve 68343 101
SS.MNS-(D2Mit6-D2Rat303)/Ayd logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50) Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 13 -7.86 null 0.27 0.97 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69068 1096
SS/Jr receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio Kreb's solution perfusate then angiotensin II (0.3-300 umol/l) and NG-nitroarginine methyl ester (100 umol/l) Dutil J, et al., Physiol Genomics 2005 Mar 1;. vasoconstriction trait male 98 days 12 50.61 % 5.29 18.33 tissue force analysis utilizing a force transducer 0.0 0 isometric force transducer 69069 1096
SD-Nfe2l2em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then angiotensin II (100 ng/kg/min) (for 3 days) Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. arterial blood pressure trait male 9 days-11 days 5 97.0 mmHg 2.9 6.48 vascular fluid filled catheter 0.0 0 100742 2520
SD-Nfe2l2em1Mcwi+/+ middle cerebral artery inner diameter controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then angiotensin II (100 ng/kg/min) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. cerebral artery size trait male 9 days-11 days 4 239.0 um 2.7 5.4 ex vivo method 0.0 0 max dilation 100747 2520
SD-Nfe2l2em1Mcwi+/+ middle cerebral artery inner diameter controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then angiotensin II (100 ng/kg/min) (for 3 days) then physiological salt solution perfusate Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. cerebral artery size trait male 9 days-11 days 4 126.0 um 12.1 24.2 ex vivo method 0.0 0 resting diameter 100753 2520
SS/JrHsdMcwi tibialis anterior muscle weight to body weight ratio common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) then angiotensin II (3 ng/kg/min) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56 days-70 days 4 TA/BW 1.74 mg/g 0.08 0.16 ex vivo method 0.0 0 TA or EDL muscle weight body weight ratio 99052 2198
SS/JrHsdMcwi tibialis anterior muscle weight to body weight ratio control condition (for 7 days) then angiotensin II (3 ng/kg/min) (for 7 days) then controlled losartan content drinking water (50 mg/kg/d) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56 days-70 days 3 TA/BW 1.77 mg/g 0.05 0.09 ex vivo method 0.0 0 TA or EDL muscle weight body weight ratio 99055 2198
SS/JrHsdMcwi tibialis anterior muscle weight to body weight ratio common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) then angiotensin II (3 ng/kg/min) (for 7 days) then controlled losartan content drinking water (50 mg/kg/d) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56 days-70 days 3 TA/BW 1.88 mg/g 0.04 0.07 ex vivo method 0.0 0 TA or EDL muscle weight body weight ratio 99056 2198
SS-Adora2bem2Mcwi heart left ventricle end-diastolic posterior wall thickness angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle posterior wall thickness male 77 days-84 days 7 2.11 mm 0.18 0.48 transthoracic echocardiography 0.0 0 105819 3023
SS/JrHsdMcwi heart left ventricle end-diastolic diameter angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle end-diastolic diameter male 63 days-70 days 5 6.63 mm 0.37 0.83 transthoracic echocardiography 0.0 0 should be inner diameter 105822 3023
SS-Adora2bem2Mcwi heart left ventricle end-diastolic diameter angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle end-diastolic diameter male 77 days-84 days 7 7.06 mm 0.22 0.58 transthoracic echocardiography 0.0 0 should be inner diameter 105825 3023
SS-Adora2bem2Mcwi heart left ventricle fractional shortening angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle end-diastolic diameter male 63 days-70 days 7 51.2 % 3.3 8.73 transthoracic echocardiography 0.0 0 105829 3023
SS-Adora2bem2Mcwi heart left ventricle weight to tibia length ratio angiotensin II (200 ng/kg/min) (for 28 days) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle mass male 77 days-84 days 8 0.18 g/cm 0.01 0.03 post excision weight measurement 0.0 0 105851 3023
WKY/NCrl absolute change in heart rate artificial cerebrospinal fluid (200 nl) then angiotensin II (90 ng) Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. heart pumping trait not specified 0 days 7 29.0 beats/min 6.0 15.87 vascular fluid filled catheter 0.0 0 110108 2685
SS/JrHsdMcwi extensor digitorum longus muscle weight to body weight ratio control condition (for 7 days) then angiotensin II (3 ng/kg/min) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56 days-70 days 4 EDL/BW 0.4 mg/g 0.02 0.04 ex vivo method 0.0 0 TA or EDL muscle weight body weight ratio 99049 2198