FHH-Chr XBN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
8 |
-8.01 |
null |
0.05 |
0.13 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
55284 |
522 |
FHH-Chr XBN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
7 |
-7.09 |
null |
0.06 |
0.16 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55634 |
522 |
FHH-Chr XBN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
-7.8 |
null |
0.09 |
0.28 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56111 |
522 |
FHH-Chr XBN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
10 |
-7.71 |
null |
0.13 |
0.4 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56114 |
522 |
FHH-Chr XBN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
10 |
0.03 |
umol/l |
0.01 |
0.02 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54915 |
522 |
FHH-Chr XBN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
-8.02 |
null |
0.07 |
0.23 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
55281 |
522 |
FHH-Chr XBN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
-7.0 |
null |
0.06 |
0.2 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55631 |
522 |
FHH-Chr XBN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
1.09 |
E-7mole |
0.15 |
0.46 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55900 |
522 |
FHH-Chr XBN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
10 |
0.94 |
E-7mole |
0.14 |
0.45 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
56529 |
522 |
FHH-Chr XBN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
male |
77 days-91 days |
7 |
3.62 |
mg/kg |
0.69 |
1.83 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58902 |
526 |
FHH-Chr XBN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
0.01 |
umol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54680 |
522 |
FHH-Chr XBN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
male |
77 days-91 days |
8 |
4.28 |
mg/kg |
1.28 |
3.62 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59179 |
526 |
FHH-Chr XBN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
8 |
0.01 |
umol/l |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54683 |
522 |
FHH-Chr XBN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
1.02 |
E-7mole |
0.09 |
0.29 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
56526 |
522 |
FHH-Chr XBN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
7 |
78.14 |
% |
4.9 |
12.95 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57233 |
522 |
FHH-Chr XBN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
female |
77 days-91 days |
7 |
2.39 |
mg/kg |
0.96 |
2.53 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
59182 |
526 |
FHH-Chr XBN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
7 |
0.86 |
E-7mole |
0.11 |
0.28 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55903 |
522 |
FHH-Chr XBN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
10 |
92.3 |
% |
3.45 |
10.92 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54789 |
522 |
FHH-Chr XBN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
9 |
-7.03 |
null |
0.04 |
0.11 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
56921 |
522 |
FHH-Chr XBN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
78.4 |
% |
3.84 |
12.16 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57230 |
522 |
FHH-Chr XBN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
9 |
86.44 |
% |
4.75 |
14.24 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54786 |
522 |
FHH-Chr XBN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
female |
77 days-91 days |
5 |
1.8 |
mg/kg |
0.65 |
1.45 |
stop flow air displacement plethysmography |
|
0 |
|
Moms and pups used in studies were fed Teklad |
58906 |
526 |
FHH-Chr XBN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
10 |
-6.96 |
null |
0.13 |
0.42 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
56924 |
522 |
FHH-Chr XBN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
0.02 |
umol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54912 |
522 |