Phenominer Database Results (24 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -8.1 null 0.06 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55303 522
FHH-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.0 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54705 522
FHH-Chr 18BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 83.0 % 6.92 20.75 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54811 522
FHH-Chr 18BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 69.56 % 4.56 13.68 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57255 522
FHH-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 -7.83 null 0.18 0.55 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56136 522
FHH-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 1.26 E-7mole 0.13 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55925 522
FHH-Chr 18BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 84.33 % 3.7 11.1 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54808 522
FHH-Chr 18BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 73.89 % 8.2 24.61 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57252 522
FHH-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54702 522
FHH-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 -8.38 null 0.05 0.16 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55306 522
FHH-Chr 18BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.7 null 0.17 0.53 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56133 522
FHH-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.31 mg/kg 0.29 0.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58916 526
FHH-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 2.1 mg/kg 0.42 1.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59201 526
FHH-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.94 mg/kg 0.38 1.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59204 526
FHH-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -6.83 null 0.07 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55653 522
FHH-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 1.62 E-7mole 0.25 0.76 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55922 522
FHH-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.04 umol/l 0.02 0.06 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54934 522
FHH-Chr 18BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.03 umol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54937 522
FHH-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.32 mg/kg 0.19 0.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58914 526
FHH-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -6.92 null 0.04 0.13 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55656 522
FHH-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 1.15 E-7mole 0.33 1.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56548 522
FHH-Chr 18BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 1.43 E-7mole 0.36 1.07 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56551 522
FHH-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -7.05 null 0.1 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56943 522
FHH-Chr 18BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -6.94 null 0.1 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56946 522