F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
4 |
61.25 |
% |
14.67 |
29.34 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62627 |
528 |
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
1 |
8.11 |
E-7mole |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
63026 |
528 |
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
4 |
-6.8 |
null |
0.15 |
0.3 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62850 |
528 |
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
1 |
-6.09 |
null |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62849 |
528 |
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
1 |
18.0 |
% |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62626 |
528 |
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
3 |
0.01 |
umol/l |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62772 |
528 |
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
1 |
-8.05 |
null |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
63094 |
528 |
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
3 |
-8.05 |
null |
0.1 |
0.17 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
63095 |
528 |
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
1 |
1.49 |
g/mg |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
63163 |
528 |
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
1 |
0.01 |
umol/l |
|
|
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
62771 |
528 |
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
4 |
1.88 |
E-7mole |
0.57 |
1.14 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
63027 |
528 |
F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
4 |
1.14 |
g/mg |
0.19 |
0.37 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
63164 |
528 |