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Study IDStudyExperiment NameExperiment NotesStrain Ont IDStrainSexAge# of AnimalsSample NotesClinical Measurement Ont IDPhenotypeFormulaClinical Measurement NotesAverage TypeValueUnitsSEMSDMethod Ont IDMethodMethod SiteMethod DurationMethod NotesPost Insult TypePost Insult Time ValuePost Insult Time UnitConditionsRecord IDCondition 1Condition 2aCondition 2bCondition 3aCondition 3b
528PhysGen Vascular datavasoconstriction traitRS:0001264F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwifemale84 days to 70 days2CMO:0000728maximum contractile force per wet weight of aorta0.65g/mg0.020.0283MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours)63169controlled sodium content diet (4 %) (for 14 days)potassium ion (80 mmol/l) (for 0.2 hours)phenylephrine (10 umol/l) (for 0.2 hours)
528PhysGen Vascular datavasoconstriction traitRS:0001264F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwimale84 days to 70 days3CMO:0000728maximum contractile force per wet weight of aorta0.58g/mg0.23090.4MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours)63165controlled sodium content diet (4 %) (for 14 days)potassium ion (80 mmol/l) (for 0.2 hours)phenylephrine (10 umol/l) (for 0.2 hours)
528PhysGen Vascular datavasodilation traitRS:0001264F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwifemale84 days to 70 days2CMO:0000724concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)2.925E-7mole0.9051.2799MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)63032controlled sodium content diet (4 %) (for 14 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
528PhysGen Vascular datavasodilation traitRS:0001264F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwimale84 days to 70 days2CMO:0000724concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)0.769E-7mole0.2090.2956MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)63028controlled sodium content diet (4 %) (for 14 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
528PhysGen Vascular datavasoconstriction traitRS:0001264F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwifemale84 days to 70 days2CMO:0000722logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)EC50 value is moles/liter-8.4320.2680.379MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours)63100controlled sodium content diet (4 %) (for 14 days)phenylephrine (0-300 umol/l) drug dose time series (for 1.2 hours)
528PhysGen Vascular datavasoconstriction traitRS:0001264F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwimale84 days to 70 days3CMO:0000722logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)EC50 value is moles/liter-8.02570.15640.2708MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours)63096controlled sodium content diet (4 %) (for 14 days)phenylephrine (0-300 umol/l) drug dose time series (for 1.2 hours)
528PhysGen Vascular datavasodilation traitRS:0001264F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwifemale84 days to 70 days2CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel26.5%13.519.0919MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)62632controlled sodium content diet (4 %) (for 14 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
528PhysGen Vascular datavasodilation traitRS:0001264F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwimale84 days to 70 days2CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel95.5%4.56.364MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)62628controlled sodium content diet (4 %) (for 14 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
528PhysGen Vascular datavasodilation traitRS:0001264F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwifemale84 days to 70 days2CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)-6.5560.1390.1966MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)62855controlled sodium content diet (4 %) (for 14 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
528PhysGen Vascular datavasodilation traitRS:0001264F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwimale84 days to 70 days2CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)-7.1310.1210.1711MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)62851controlled sodium content diet (4 %) (for 14 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
528PhysGen Vascular datavasoconstriction traitRS:0001264F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwifemale84 days to 70 days2CMO:0000721concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)0.0044umol/l0.00240.0034MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours)62777controlled sodium content diet (4 %) (for 14 days)phenylephrine (0-300 umol/l) drug dose time series (for 1.2 hours)
528PhysGen Vascular datavasoconstriction traitRS:0001264F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwimale84 days to 70 days3CMO:0000721concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)0.0106umol/l0.00310.0054MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours)62773controlled sodium content diet (4 %) (for 14 days)phenylephrine (0-300 umol/l) drug dose time series (for 1.2 hours)