FHH-Chr 20BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
-7.67 |
null |
0.04 |
0.14 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56132 |
522 |
FHH-Chr 20BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
10 |
0.02 |
umol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54703 |
522 |
FHH-Chr 20BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
10 |
70.6 |
% |
4.2 |
13.28 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54809 |
522 |
FHH-Chr 20BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
10 |
-7.83 |
null |
0.11 |
0.34 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
55304 |
522 |
FHH-Chr 20BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
9 |
-6.94 |
null |
0.04 |
0.13 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55654 |
522 |
FHH-Chr 20BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
10 |
0.02 |
umol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54935 |
522 |
FHH-Chr 20BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
9 |
64.78 |
% |
6.27 |
18.82 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57253 |
522 |
FHH-Chr 20BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
-6.88 |
null |
0.06 |
0.19 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
56942 |
522 |
FHH-Chr 20BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
9 |
-7.81 |
null |
0.17 |
0.51 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
55302 |
522 |
FHH-Chr 20BN/Mcwi |
maximum contractile force per wet weight of aorta |
potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
9 |
0.93 |
g/mg |
0.14 |
0.43 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55815 |
522 |
FHH-Chr 20BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
8 |
1.15 |
E-7mole |
0.17 |
0.48 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55921 |
522 |
FHH-Chr 20BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
8 |
69.0 |
% |
11.7 |
33.08 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57251 |
522 |
FHH-Chr 20BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
10 |
-6.9 |
null |
0.06 |
0.19 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
56944 |
522 |
FHH-Chr 20BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
8 |
-6.99 |
null |
0.09 |
0.26 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55652 |
522 |
FHH-Chr 20BN/Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
9 |
0.95 |
g/mg |
0.14 |
0.42 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57361 |
522 |
FHH-Chr 20BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
85.9 |
% |
4.5 |
14.22 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54807 |
522 |
FHH-Chr 20BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
0.02 |
umol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54933 |
522 |
FHH-Chr 20BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
1.43 |
E-7mole |
0.21 |
0.65 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
56547 |
522 |
FHH-Chr 20BN/Mcwi |
maximum contractile force per wet weight of aorta |
potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
9 |
1.21 |
g/mg |
0.17 |
0.52 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55817 |
522 |
FHH-Chr 20BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
10 |
1.39 |
E-7mole |
0.2 |
0.62 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
56549 |
522 |
FHH-Chr 20BN/Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
10 |
1.59 |
g/mg |
0.2 |
0.62 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
57363 |
522 |
FHH-Chr 20BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
9 |
1.21 |
E-7mole |
0.13 |
0.4 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
55923 |
522 |
FHH-Chr 20BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
9 |
0.02 |
umol/l |
0.01 |
0.02 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
Moms and pups used in studies were fed Teklad |
54701 |
522 |
FHH-Chr 20BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
10 |
-7.77 |
null |
0.08 |
0.26 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56134 |
522 |