Phenominer Database Results (244 results)

 
 
Table "column sort" updates the order of the bars in the chart.
Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Value Units SEM SD Individual Records Method Method Duration Post Insult Time Value Experiment Notes Record ID Study ID
FHH-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 2.57 mg/kg 0.74 2.22 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58898 526
SHR/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 15 1.68 mg/kg 0.23 0.91 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58900 526
SS-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 0.86 mg/kg 0.16 0.43 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58910 526
FHH-Chr 1BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 2.96 mg/kg 1.01 3.03 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58932 526
SS-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 1.73 mg/kg 0.14 0.46 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58933 526
FHH-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 4.44 mg/kg 1.7 4.17 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58937 526
SS-Chr 6BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 1.19 mg/kg 0.19 0.6 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58939 526
FHH-Chr 17BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.32 mg/kg 0.36 1.03 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58954 526
FHH-Chr 19BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.84 mg/kg 0.27 0.81 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58959 526
BN/NHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 19 2.97 mg/kg 0.71 3.09 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58985 526
SS-Chr XBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 1.71 mg/kg 0.31 0.87 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58986 526
FHH-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 2.34 mg/kg 0.46 1.46 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58988 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.19 mg/kg 0.28 0.89 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59150 526
SS-Chr 6BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 1.0 mg/kg 0.14 0.43 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59156 526
SS-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.14 mg/kg 0.14 0.46 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59161 526
FHH-Chr 10BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 5 3.25 mg/kg 1.29 2.88 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59170 526
SS-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 11 1.21 mg/kg 0.17 0.56 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59178 526
SS-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 0.97 mg/kg 0.16 0.48 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59180 526
SS-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.66 mg/kg 0.31 0.81 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59194 526
SS-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 0.72 mg/kg 0.19 0.53 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59197 526
SS-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 11 1.39 mg/kg 0.19 0.64 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59198 526
SS-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 1.06 mg/kg 0.13 0.41 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59205 526
SS-Chr YBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 17 2.21 mg/kg 0.37 1.52 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59210 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 0.9 mg/kg 0.1 0.32 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59224 526
SS-Chr 19BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.13 mg/kg 0.17 0.52 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59229 526
FHH-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.86 mg/kg 0.3 0.85 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59230 526
BN/NHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 14 1.73 mg/kg 0.29 1.1 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59236 526
LEW/Crl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 5.59 mg/kg 1.03 3.1 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57764 526
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 0.8 mg/kg 0.15 0.39 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58593 526
SS-Chr 17BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 0.89 mg/kg 0.32 0.85 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58948 526
GH/OmrMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 16 3.84 mg/kg 0.47 1.89 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58950 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 0.6 mg/kg 0.16 0.49 Download Values stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58884 526
SS-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.46 mg/kg 0.22 0.65 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58923 526
FHH-Chr 4BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 2.68 mg/kg 0.43 1.05 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58924 526
F344/DuCrl dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 2.3 mg/kg 0.67 1.77 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60109 526
LE/BluGill dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 13 2.96 mg/kg 0.5 1.8 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60111 526
WKY/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 11 1.0 mg/kg 0.18 0.61 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60113 526
BN/NHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 18 1.44 mg/kg 0.17 0.71 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58984 526
SS-Chr 10BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 14 0.82 mg/kg 0.13 0.49 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59149 526
FHH-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.78 mg/kg 0.21 0.63 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59160 526
FHH-Chr XBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 4.28 mg/kg 1.28 3.62 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59179 526
SS-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 12 1.45 mg/kg 0.3 1.05 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58913 526
SS-Chr 19BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 0.99 mg/kg 0.18 0.58 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58928 526
SS-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 0.7 mg/kg 0.16 0.39 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58931 526
SS-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 17 0.82 mg/kg 0.1 0.4 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58938 526
SS-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 1.2 mg/kg 0.21 0.7 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58962 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 51 3.06 mg/kg 0.29 2.04 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58969 526
SS-Chr 4BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 1.05 mg/kg 0.15 0.5 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59220 526
SS-Chr XBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.2 mg/kg 0.21 0.55 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59237 526
WKY/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.5 mg/kg 0.28 0.84 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57763 526
LE/BluGill dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 12 6.02 mg/kg 1.82 6.29 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57768 526
FHH-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 1.05 mg/kg 0.17 0.54 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58915 526
FHH-Chr 4BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 6 3.05 mg/kg 1.07 2.61 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58922 526
SS-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.64 mg/kg 0.29 0.78 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58927 526
FHH-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 1.02 mg/kg 0.22 0.62 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58941 526
FHH-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 3.81 mg/kg 0.73 1.93 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58945 526
FHH-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.71 mg/kg 0.41 1.09 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58960 526
FHH-Chr 19BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 1.84 mg/kg 0.44 1.4 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58963 526
FHH-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 2.54 mg/kg 0.52 1.65 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58966 526
FHH-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 3.32 mg/kg 0.82 2.18 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58970 526
FHH-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 2.25 mg/kg 0.56 1.49 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59151 526
FHH-Chr 6BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 4.89 mg/kg 1.13 3.57 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59155 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 0.88 mg/kg 0.11 0.33 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59158 526
FHH-Chr 6BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.12 mg/kg 0.18 0.51 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59159 526
SS-Chr 17BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.03 mg/kg 0.16 0.51 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59169 526
FHH-Chr 17BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.69 mg/kg 0.57 1.63 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59177 526
FHH-Chr 10BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 6 2.19 mg/kg 0.43 1.05 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59181 526
FHH-Chr 19BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 1.36 mg/kg 0.22 0.72 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59186 526
SS-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.02 mg/kg 0.22 0.65 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59191 526
FHH-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 2.06 mg/kg 0.37 1.03 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59202 526
SS-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 22 1.65 mg/kg 0.29 1.35 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59203 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 56 3.23 mg/kg 0.36 2.67 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59206 526
SS-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 14 1.26 mg/kg 0.2 0.75 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59211 526
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 4 1.42 mg/kg 0.31 0.63 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57983 526
SS-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 4 0.71 mg/kg 0.16 0.32 Download Values stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58473 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 3 6.85 mg/kg 0.94 1.64 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58603 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 5.84 mg/kg 1.89 4.62 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58846 526
SS-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 4 1.23 mg/kg 0.37 0.74 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58847 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 3.46 mg/kg 0.78 2.06 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58852 526
SHR/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.34 mg/kg 0.19 0.59 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58854 526
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.61 mg/kg 0.31 0.83 Download Values stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58881 526
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 5 1.01 mg/kg 0.28 0.63 Download Values stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58883 526
FHH-Chr 6BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 6 1.84 mg/kg 0.25 0.61 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58894 526
SS-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.06 mg/kg 0.12 0.32 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58904 526
FHH-Chr 8BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 2.28 mg/kg 0.55 1.66 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58907 526
FHH-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 2.42 mg/kg 0.72 2.17 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58934 526
SS-Chr 6BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 2.67 mg/kg 0.84 2.23 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58944 526
FHH-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 3.38 mg/kg 0.87 2.31 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58947 526
SS-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 13 1.52 mg/kg 0.24 0.85 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58964 526
FHH-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 2.15 mg/kg 0.8 2.12 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58965 526
SS-Chr 1BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.92 mg/kg 0.5 1.59 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58974 526
SS-Chr 1BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 2.0 mg/kg 0.49 1.38 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58976 526
SS-Chr 4BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 18 1.1 mg/kg 0.14 0.6 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58981 526
F344/DuCrl dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 12 2.98 mg/kg 0.68 2.34 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60114 526
LE/BluGill dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 15 2.81 mg/kg 0.74 2.87 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60115 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 4 1.02 mg/kg 0.17 0.34 Download Values stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58471 526
FHH-Chr 8BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 6 2.94 mg/kg 0.88 2.17 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58911 526
SS-Chr 19BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.18 mg/kg 0.26 0.79 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58926 526
SS-Chr 9BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.64 mg/kg 0.24 0.65 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58943 526
FHH-Chr 19BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.56 mg/kg 0.28 0.85 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59193 526
SS-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 0.99 mg/kg 0.22 0.66 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59226 526
FHH-Chr 9BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 2.82 mg/kg 0.78 2.05 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59231 526
FHH-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 2.3 mg/kg 0.48 1.44 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59171 526
SS-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.2 mg/kg 0.23 0.66 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59176 526
F344/DuCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 14 3.69 mg/kg 0.79 2.96 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57766 526
F344/DuCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 13 3.49 mg/kg 0.6 2.15 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57771 526
FHH-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 11 1.93 mg/kg 0.35 1.16 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58891 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.15 mg/kg 0.26 0.73 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58896 526
SS-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 1.64 mg/kg 0.21 0.7 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58918 526
SS-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.22 mg/kg 0.29 0.87 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58920 526
FHH-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.63 mg/kg 0.32 0.9 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58936 526
SS-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 19 0.91 mg/kg 0.09 0.4 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58942 526
FHH-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.96 mg/kg 0.37 1.11 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58957 526
FHH-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 2.04 mg/kg 0.49 1.46 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59166 526
SS-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.26 mg/kg 0.24 0.77 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59172 526
FHH-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 2.56 mg/kg 0.46 1.46 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59183 526
FHH-Chr 8BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 2.61 mg/kg 0.36 0.94 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59184 526
SS-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 18 1.58 mg/kg 0.31 1.3 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59185 526
SS-Chr 4BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 20 1.95 mg/kg 0.24 1.05 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58977 526
FHH-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 6 2.2 mg/kg 0.44 1.08 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58979 526
FHH-Chr 9BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 6 4.32 mg/kg 1.59 3.9 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58987 526
FHH-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 0.84 mg/kg 0.14 0.34 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59153 526
FHH-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 2.23 mg/kg 0.44 1.33 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59200 526
FHH-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 3.42 mg/kg 0.81 2.28 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59208 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 88 1.36 mg/kg 0.1 0.97 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59213 526
SS-Chr 1BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 6 1.31 mg/kg 0.18 0.43 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59214 526
SS-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.55 mg/kg 0.17 0.52 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59217 526
SS-Chr 1BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.2 mg/kg 0.17 0.49 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59219 526
FHH-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 2.86 mg/kg 0.55 1.57 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59238 526
Crl:CD(SD) dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 2.85 mg/kg 0.98 2.6 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57765 526
LEW/Crl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 9.07 mg/kg 1.3 3.68 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57769 526
WKY/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.5 mg/kg 0.36 1.08 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57770 526
SS-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 5 1.06 mg/kg 0.45 1.01 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58601 526
SS-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 5 0.69 mg/kg 0.11 0.23 Download Values stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58472 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.38 mg/kg 0.29 0.78 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58892 526
FHH-Chr 10BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 6 2.21 mg/kg 0.55 1.35 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58905 526
FHH-Chr 1BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 13 2.78 mg/kg 0.54 1.93 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58921 526
SS-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 14 1.26 mg/kg 0.18 0.68 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58961 526
SS-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 16 1.02 mg/kg 0.19 0.76 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58968 526
WKY/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.12 mg/kg 0.28 0.74 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60106 526
GH/OmrMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 2.33 mg/kg 0.42 1.27 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58855 526
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.75 mg/kg 0.34 0.89 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58592 526
FHH-Chr 6BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 2.18 mg/kg 0.39 1.1 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58895 526
FHH-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 2.18 mg/kg 0.48 1.6 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58897 526
FHH-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.31 mg/kg 0.29 0.86 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58916 526
SS-Chr 10BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 0.62 mg/kg 0.06 0.18 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58935 526
FHH-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 2.24 mg/kg 0.37 1.1 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59168 526
FHH-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 2.58 mg/kg 0.29 0.87 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59199 526
FHH-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 2.1 mg/kg 0.42 1.19 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59201 526
FHH-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.94 mg/kg 0.38 1.14 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59204 526
FHH-Chr 4BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.2 mg/kg 0.42 1.19 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59223 526
SS-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 1.51 mg/kg 0.37 0.91 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58967 526
FHH-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 5 1.2 mg/kg 0.37 0.83 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58980 526
FHH-Chr 9BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 2.98 mg/kg 1.12 3.17 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59239 526
SS-Chr 6BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 1.32 mg/kg 0.17 0.47 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59163 526
FHH-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 2.17 mg/kg 0.56 1.58 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59167 526
SS-Chr 17BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 0.63 mg/kg 0.08 0.24 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59175 526
FHH-Chr XBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 2.39 mg/kg 0.96 2.53 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59182 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 0.81 mg/kg 0.17 0.48 Download Values stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58880 526
SHR/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 14 1.42 mg/kg 0.26 0.99 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58903 526
FHH-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.66 mg/kg 0.28 0.88 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58912 526
SS-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.54 mg/kg 0.23 0.62 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58929 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.79 mg/kg 0.27 0.84 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58930 526
FHH-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.39 mg/kg 0.45 1.28 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58949 526
SS-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 0.69 mg/kg 0.16 0.39 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59192 526
FHH-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 2.66 mg/kg 0.69 1.83 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59195 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 12 1.11 mg/kg 0.17 0.6 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59221 526
FHH-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 1.38 mg/kg 0.16 0.45 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59222 526
BN/NHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 16 1.44 mg/kg 0.18 0.74 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59235 526
SS-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.67 mg/kg 0.37 1.18 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59240 526
Crl:CD(SD) dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 4.15 mg/kg 1.12 3.16 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57767 526
LE/BluGill dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 12 6.24 mg/kg 1.7 5.88 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57772 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 4 1.48 mg/kg 0.21 0.43 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58599 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.26 mg/kg 0.45 1.18 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58604 526
SS-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 1.3 mg/kg 0.19 0.55 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58844 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 17 1.35 mg/kg 0.17 0.7 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58845 526
GH/OmrMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 2.69 mg/kg 0.62 1.65 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58850 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 13 1.11 mg/kg 0.24 0.85 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58853 526
SS-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.59 mg/kg 0.55 1.45 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58901 526
SS-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 26 1.08 mg/kg 0.1 0.5 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58908 526
SS-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.09 mg/kg 0.23 0.7 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58909 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.2 mg/kg 0.25 0.71 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58925 526
SS-Chr 17BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 0.69 mg/kg 0.1 0.28 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58953 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 98 1.6 mg/kg 0.11 1.12 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58973 526
LEW/Crl dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 2.47 mg/kg 0.7 2.1 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60107 526
Crl:CD(SD) dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 2.02 mg/kg 0.47 1.24 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60108 526
LEW/Crl dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 3.48 mg/kg 0.53 1.39 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60112 526
SS-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.31 mg/kg 0.42 1.12 Download Values stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58879 526
FHH-Chr YBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 13 2.97 mg/kg 0.54 1.96 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58919 526
SS-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.55 mg/kg 0.28 0.79 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59188 526
SS-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.21 mg/kg 0.26 0.83 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59190 526
FHH-Chr 8BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 5.14 mg/kg 1.05 2.96 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59196 526
SS-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 1.85 mg/kg 0.4 1.32 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59207 526
SS-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.24 mg/kg 0.12 0.37 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59212 526
SS-Chr XBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 0.92 mg/kg 0.09 0.27 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59215 526
FHH-Chr 4BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 3.09 mg/kg 0.91 2.42 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59218 526
SS-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 1.08 mg/kg 0.37 0.91 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59234 526
FHH-Chr 9BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 4 5.45 mg/kg 3.08 6.16 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58982 526
SS-Chr 9BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.13 mg/kg 0.2 0.52 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59157 526
SS-Chr 10BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 11 0.73 mg/kg 0.07 0.22 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59165 526
FHH-Chr 17BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 6 2.54 mg/kg 0.7 1.71 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59174 526
SS-Chr 10BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 0.65 mg/kg 0.05 0.17 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58946 526
SS-Chr XBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 1.81 mg/kg 0.47 1.5 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58975 526
FHH-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 2.06 mg/kg 0.52 1.38 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59147 526
FHH-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 2.1 mg/kg 0.49 1.55 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59148 526
FHH-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 2.74 mg/kg 0.26 0.85 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59164 526
FHH-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 1.65 mg/kg 0.45 1.42 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58983 526
FHH-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.32 mg/kg 0.19 0.56 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58914 526
SS-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 38 1.67 mg/kg 0.25 1.55 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58917 526
FHH-Chr 17BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.36 mg/kg 0.27 0.8 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58952 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 19 4.0 mg/kg 1.04 4.52 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58958 526
SS-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 14 1.49 mg/kg 0.23 0.86 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58971 526
GH/OmrMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 3 2.97 mg/kg 1.09 1.9 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59173 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 12 2.03 mg/kg 0.4 1.38 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59187 526
FHH-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 1.95 mg/kg 0.52 1.27 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59189 526
FHH-Chr 1BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 17 2.89 mg/kg 0.49 2.02 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59216 526
SS-Chr 19BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 1.53 mg/kg 0.26 0.75 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59225 526
FHH-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 1.87 mg/kg 0.42 1.04 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59227 526
SS-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 11 1.2 mg/kg 0.2 0.68 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59232 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 14 1.23 mg/kg 0.21 0.8 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59233 526
FHH-Chr 1BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 12 1.72 mg/kg 0.49 1.71 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59241 526
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 1.52 mg/kg 0.29 0.81 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57982 526
SHR/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 2.0 mg/kg 0.63 1.67 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58848 526
SS-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 1.08 mg/kg 0.12 0.39 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58849 526
SS-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 1.15 mg/kg 0.22 0.63 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58851 526
SS-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 0.61 mg/kg 0.14 0.38 Download Values stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58882 526
FHH-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 2.88 mg/kg 0.7 1.97 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58893 526
FHH-Chr 10BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.7 mg/kg 0.41 1.24 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58899 526
FHH-Chr XBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 5 1.8 mg/kg 0.65 1.45 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58906 526
SS-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 11 1.55 mg/kg 0.26 0.86 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58956 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.32 mg/kg 0.29 0.88 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58978 526
Crl:CD(SD) dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.82 mg/kg 0.44 1.32 Download Values stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60110 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 3 5.76 mg/kg 2.11 3.65 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58600 526
SS-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 0.88 mg/kg 0.2 0.54 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58602 526
SS-Chr YBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 17 1.56 mg/kg 0.23 0.96 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58972 526
FHH-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 4 3.54 mg/kg 1.04 2.08 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59152 526
SS-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 0.65 mg/kg 0.06 0.19 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59154 526
SS-Chr 9BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.02 mg/kg 0.21 0.55 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59162 526
FHH-Chr XBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 3.62 mg/kg 0.69 1.83 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58902 526
SS-Chr 9BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.6 mg/kg 0.38 1.19 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58940 526
FHH-Chr YBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 14 1.13 mg/kg 0.19 0.73 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59209 526
SS-Chr 4BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 12 1.2 mg/kg 0.2 0.71 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59228 526
SS-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.88 mg/kg 0.39 1.24 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58951 526
GH/OmrMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 14 2.59 mg/kg 0.68 2.55 Download Values stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58955 526