Phenominer Database Results (477 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 1.45 beats/min 8.08 24.25 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51261 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 9 5.85 beats/min 9.6 28.81 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51263 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 20 1.46 mEq/d 0.2 0.9 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51266 481
GH/OmrMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 8 1.32 mEq/d 0.09 0.25 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51272 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 3 0.95 mEq/d 0.15 0.26 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51275 481
Hsd:SD plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 11 0.32 mg/dl 0.03 0.11 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51277 481
SS-Chr 20BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 11 0.32 mg/dl 0.02 0.06 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51311 481
SS-Chr 9BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 13 0.32 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51317 481
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 108.35 mmHg 1.6 4.22 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51328 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 5 394.09 beats/min 7.89 17.63 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51379 481
SS-Chr 16BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 423.79 beats/min 7.38 16.5 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51382 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 14 8.24 beats/min 8.8 32.91 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51401 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 -5.54 mmHg 2.16 6.48 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51066 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 18 -17.17 beats/min 7.62 32.34 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51088 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 10 21.46 beats/min 11.94 37.77 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51091 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 -5.64 mmHg 2.48 5.55 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50764 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 3 -6.83 mmHg 2.51 4.35 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50765 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 7 0.35 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51171 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 5 0.32 mg/dl 0.01 0.01 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51181 481
GH/OmrMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 8 0.31 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51182 481
SS-Chr 16BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 390.2 beats/min 8.98 21.99 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51246 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 321.19 beats/min 5.4 15.26 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51249 481
FHH/EurMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 8 0.91 mEq/d 0.16 0.46 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51515 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 20 1.21 mEq/d 0.14 0.65 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51516 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 2 1.55 ml/min 0.17 0.24 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51548 481
GH/OmrMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 8 2.13 ml/min 0.12 0.33 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51551 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 4 7.64 beats/min 18.08 36.17 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50976 481
GH/OmrMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 14.04 beats/min 6.89 19.49 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50983 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 5 -28.94 beats/min 6.27 14.02 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50988 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 5 12.61 ng/ml/h 1.89 4.23 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51002 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 3 1.67 ng/ml/h 0.55 0.96 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51006 481
SS-Chr 20BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 9 1.9 ng/ml/h 0.26 0.78 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51012 481
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 1 8.99 ng/ml/h radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51014 481
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 3 7.64 ng/ml/h 1.68 2.91 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51015 481
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 6 1.16 mEq/d 0.25 0.62 flame atomic emission spectrometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51044 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 4 1.03 ml/min 0.2 0.41 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51055 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 3 1.39 ml/min 0.23 0.41 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51063 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 380.26 beats/min 6.27 15.36 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50886 481
SS-Chr 20BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 14 429.29 beats/min 17.71 66.26 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50887 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 4.05 beats/min 12.42 32.85 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50909 481
BN/NHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 20 serial mean 27.0 mmHg 2.0 8.94 vascular indwelling catheter method left femoral artery 0.0 0 67299 151
BN/NHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 20 serial mean 25.0 mmHg 3.0 13.42 vascular indwelling catheter method left femoral artery 0.0 0 67303 151
WKY/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 336.79 beats/min 11.9 35.71 vascular fluid filled catheter 0 51780 481
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days-94 days 14 serial mean 110.0 mmHg 3.0 11.22 vascular indwelling catheter method left femoral artery 0 0 65462 151
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days-94 days 12 serial mean 160.0 mmHg 6.0 20.78 vascular indwelling catheter method left femoral artery 0 0 65463 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days-94 days 14 serial mean 72.0 mmHg 2.0 7.48 vascular indwelling catheter method left femoral artery 0 0 65464 151
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days-94 days 12 serial mean 126.0 mmHg 5.0 17.32 vascular indwelling catheter method left femoral artery 0 0 65465 151
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 -11.5 beats/min 9.79 29.36 vascular fluid filled catheter 0 52064 481
LEW/Crl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -16.77 beats/min 3.09 6.9 vascular fluid filled catheter 0 52065 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 6 13.14 ng/ml/h 1.17 2.86 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50567 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 -21.19 mmHg 2.27 6.01 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50625 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 -23.04 mmHg 2.62 6.92 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50634 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 1 5.59 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50636 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 3 -2.03 mmHg 7.23 12.52 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50637 481
WKY/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 8 6.96 ng/ml/h 0.75 2.12 radioimmunoassay 0 51957 481
SS-Chr 20BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 13 124.79 mmHg 2.58 9.3 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51998 481
GH/OmrMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 9 160.79 mmHg 5.64 16.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51999 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 4 137.89 mmHg 7.62 15.25 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52007 481
WKY/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.42 mg/dl 0.03 0.07 radioimmunoassay 0 50412 481
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (100 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 132.9 mmHg 3.8 17.41 vascular indwelling catheter method left femoral artery 120.0 0 69531 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 111.3 mmHg 4.6 21.08 vascular indwelling catheter method left femoral artery 120.0 0 69541 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 138.6 mmHg 3.8 17.41 vascular indwelling catheter method left femoral artery 120.0 0 69547 151
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood creatinine amount female 92 days-94 days 8 0.42 mg/dl 0.11 0.31 plasma creatinine analysis 0.0 0 urine potassium analysis umol/min 69485 151
SS/JrHsdMcwi timed urine volume controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine output female 92 days-94 days 15 7.8 ml/d 0.6 2.32 urine volume measurement method 0.0 0 needs ml/d default 69465 151
SS/JrHsdMcwi urine potassium excretion rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine potassium amount female 92 days-94 days 14 0.92 mEq/d 0.07 0.27 unspecified method 0.0 0 urine potassium analysis umol/min 69474 151
WKY heart left ventricle infarction size to total heart left ventricle size ratio left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle integrity trait male 266 days-280 days 32 30.9 % 8.1 45.82 ex vivo microscopy with digital image analysis 0.0 lad occlusion 210 days 100266 2460
WKY heart rate left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart pumping trait male 266 days-280 days 32 373.0 beats/min 15.0 84.85 echocardiography 0.0 lad occlusion 210 days 100314 2460
WKY serum potassium level left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. blood potassium amount male 266 days-280 days 16 5.0 mmol/l 0.19 0.76 automated serum potassium test 0.0 lad occlusion 210 days 100334 2460
WKY heart ventricle septal wall thickness left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle wall thickness male 238 days-252 days 20 0.13 cm 0.03 0.13 echocardiography 0.0 lad occlusion 196 days 100337 2460
WKY heart posterior wall thickness left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle posterior wall thickness male 238 days-252 days 20 0.17 cm 0.01 0.04 echocardiography 0.0 lad occlusion 196 days 100346 2460
WKY ejection fraction left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. cardiac output trait male 238 days-252 days 20 35.5 % 2.0 8.94 echocardiography 0.0 lad occlusion 196 days 100352 2460
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 4 2.03 mmHg 7.31 14.61 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50811 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 10 -2.98 mmHg 0.76 2.39 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50635 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 4 387.54 beats/min 13.35 26.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50888 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 4 392.72 beats/min 8.3 16.6 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50890 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 5 8.29 beats/min 21.22 47.46 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50905 481
Hsd:SD creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 9 1.85 ml/min 0.15 0.44 urine creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51402 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 9 1.03 mEq/d 0.18 0.54 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51524 481
SS-Chr 16BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 7 1.93 ml/min 0.1 0.27 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51546 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 10 1.46 mEq/d 0.11 0.36 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51270 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 5 0.28 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51315 481
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 108.6 mmHg 0.71 1.58 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51326 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 147.84 mmHg 6.57 16.08 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51329 481
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 8 3.34 ng/ml/h 0.14 0.39 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50393 481
F344/DuCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 111.8 mmHg 2.06 6.17 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51732 481
Hsd:SD mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 12 114.44 mmHg 1.98 6.87 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51788 481
BN/NHsdMcwi plasma total cholesterol level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood cholesterol amount female 92 days-94 days 10 56.0 mg/dl 2.1 6.64 plasma total cholesterol measurement test 0.0 0 67289 151
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 -1.91 mmHg 2.6 6.36 vascular fluid filled catheter 0 51917 481
GH/OmrMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 181.05 mmHg 7.86 22.24 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52003 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 5 91.89 mmHg 3.36 7.51 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52008 481
BN/NHsdMcwi urine sodium level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 92 days-94 days 22 100.4 mmol/l 6.5 30.49 unspecified method 0.0 0 urine sodium analysis 69466 151
SS/JrHsdMcwi urine potassium level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine potassium amount female 92 days-94 days 14 124.4 mmol/l 8.8 32.93 unspecified method 0.0 0 urine potassium analysis 69472 151
WKY body weight left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. body mass male 266 days-280 days 32 574.0 g 38.0 214.96 body weighing method 0.0 lad occlusion 210 days 100275 2460
WKY heart left ventricle weight left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle mass male 266 days-280 days 16 1.04 g 0.13 0.51 post excision weight measurement 0.0 lad occlusion 210 days 100292 2460
WKY ejection fraction left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. cardiac output trait male 266 days-280 days 16 38.5 % 3.2 12.8 echocardiography 0.0 lad occlusion 210 days 100301 2460
WKY heart rate left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart pumping trait male 266 days-280 days 16 362.0 beats/min 31.0 124.0 echocardiography 0.0 lad occlusion 210 days 100313 2460
WKY serum potassium level left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. blood potassium amount male 266 days-280 days 32 4.9 mmol/l 0.1 0.57 automated serum potassium test 0.0 lad occlusion 210 days 100335 2460
SS/JrHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 39.0 mmHg 6.0 21.63 vascular indwelling catheter method left femoral artery 0.0 0 67302 151
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 -2.18 mmHg 2.36 5.28 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51067 481
GH/OmrMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 0.56 beats/min 2.95 8.35 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51094 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 3 -11.61 beats/min 15.08 26.12 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51098 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 -6.56 beats/min 8.43 18.85 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50980 481
SS-Chr 9BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 13 8.0 beats/min 11.17 40.27 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50981 481
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 14 37.45 beats/min 19.76 73.94 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50986 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 4 36.95 beats/min 7.33 14.67 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50987 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 4 -5.24 beats/min 10.35 20.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50989 481
GH/OmrMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 9 3.39 ng/ml/h 0.88 2.65 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51005 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 5 6.62 ng/ml/h 1.19 2.66 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51008 481
FHH/EurMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 8 1.37 mEq/d 0.05 0.15 flame atomic emission spectrometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51046 481
SS-Chr 16BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 6 1.16 mEq/d 0.02 0.04 flame atomic emission spectrometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51047 481
FHH/EurMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 5 1.14 ml/min 0.11 0.24 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51051 481
GH/OmrMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 9 0.71 ml/min 0.07 0.2 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51054 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 4 0.59 ml/min 0.17 0.33 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51060 481
GH/OmrMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 9 -11.35 mmHg 4.78 14.34 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50803 481
SS-Chr 20BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 14 -15.73 mmHg 1.65 6.17 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50810 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 5 -7.15 mmHg 2.83 6.32 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50812 481
Hsd:SD heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 12 397.17 beats/min 12.82 44.43 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50814 481
LEW/Crl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 97.54 mmHg 1.66 3.71 vascular fluid filled catheter 0 50837 481
LEW/Crl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 4 96.06 mmHg 2.3 4.61 vascular fluid filled catheter 0 50838 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 389.31 beats/min 12.58 28.14 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50877 481
GH/OmrMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 9 419.89 beats/min 5.87 17.6 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50880 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 5 375.46 beats/min 8.18 18.29 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50889 481
Hsd:SD creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 13 1.09 ml/min 0.1 0.37 urine creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51403 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 2 0.73 ml/min 0.02 0.02 urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51451 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 5 -18.8 mmHg 3.71 8.29 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50761 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 -2.84 mmHg 7.8 17.44 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50800 481
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 7 0.91 mEq/d 0.11 0.28 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51519 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 2 0.37 mg/dl 0.07 0.09 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51537 481
FHH/EurMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 7 1.45 ml/min 0.17 0.46 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51542 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 7 0.29 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51175 481
GH/OmrMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 3 0.28 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51176 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 431.85 beats/min 7.73 20.45 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51244 481
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 8 1.25 mEq/d 0.15 0.43 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51264 481
SS-Chr 16BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 6 1.4 mEq/d 0.14 0.34 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51267 481
SS-Chr 20BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 10 0.35 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51319 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 133.34 mmHg 4.01 10.6 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51325 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 34.0 mmHg 3.0 10.82 vascular indwelling catheter method left femoral artery 0.0 0 67300 151
LEW/Crl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 380.88 beats/min 3.51 7.84 vascular fluid filled catheter 0 51781 481
WKY/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 390.89 beats/min 8.33 20.42 vascular fluid filled catheter 0 51783 481
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (0.4 %) (for 35 days) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renin activity female 95 days 11 9.6 ng/ml/h 1.0 3.32 ex vivo blood analysis 0 0 65474 151
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 129.19 mmHg 3.08 7.55 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51822 481
GH/OmrMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 146.56 mmHg 2.45 6.94 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51827 481
LEW/Crl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 4 4.31 ng/ml/h 1.53 3.06 radioimmunoassay 0 51959 481
WKY/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 6 6.9 ng/ml/h 2.37 5.82 radioimmunoassay 0 51960 481
SS-Chr 9BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 13 121.91 mmHg 2.36 8.51 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52001 481
SS-Chr 20BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 14 122.5 mmHg 2.84 10.64 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52006 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 4 91.79 mmHg 3.28 6.56 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52009 481
LEW/Crl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 4 2.35 ml/min 0.29 0.57 urine creatinine analysis 0 52029 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 5 2.8 ng/ml/h 0.87 1.94 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50565 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 -3.9 mmHg 1.51 3.99 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50626 481
GH/OmrMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 -17.3 mmHg 2.31 6.52 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50633 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 9 11.85 ng/ml/h 0.69 2.08 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50394 481
GH/OmrMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 8 11.16 ng/ml/h 0.5 1.41 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50397 481
WKY/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 8 1.16 mEq/d 0.2 0.56 flame atomic emission spectrometry 0 50439 481
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 111.8 mmHg 3.9 17.87 vascular indwelling catheter method left femoral artery 120.0 0 69527 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (100 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 147.2 mmHg 3.9 14.06 vascular indwelling catheter method left femoral artery 120.0 0 69532 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 139.1 mmHg 3.6 16.5 vascular indwelling catheter method left femoral artery 120.0 0 69533 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 9 serial mean 132.0 mmHg 7.0 21.0 vascular indwelling catheter method left femoral artery 120.0 0 69542 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 137.4 mmHg 4.0 18.33 vascular indwelling catheter method left femoral artery 120.0 0 69545 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 9 serial mean 160.0 mmHg 6.7 20.1 vascular indwelling catheter method left femoral artery 120.0 0 69548 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 17 serial mean 144.9 mmHg 3.1 12.78 vascular indwelling catheter method left femoral artery 120.0 0 69549 151
BN/NHsdMcwi white blood cell count controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. leukocyte quantity female 92 days-94 days 13 0.02 x 1000 cells/ul 1306.0 4708.85 isolated cell counting method 0.0 0 69495 151
SS/JrHsdMcwi plasma high density lipoprotein cholesterol level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood HDL cholesterol amount female 92 days-94 days 12 68.1 mg/dl 4.5 15.59 plasma high-density lipoprotein-cholesterol measurement test 0.0 0 69504 151
BN/NHsdMcwi urine potassium level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine potassium amount female 92 days-94 days 22 93.4 mmol/l 5.7 26.74 unspecified method 0.0 0 urine potassium analysis 69471 151
WKY body weight left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. body mass male 266 days-280 days 16 599.0 g 35.0 140.0 body weighing method 0.0 lad occlusion 210 days 100274 2460
WKY heart weight left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart mass male 238 days-252 days 20 1.56 g 0.42 1.86 post excision weight measurement 0.0 lad occlusion 196 days 100277 2460
WKY heart left ventricle end-systolic diameter left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle end-systolic diameter male 266 days-280 days 16 9.1 mm 0.4 1.6 echocardiography 0.0 lad occlusion 210 days 100310 2460
WKY left ventricular end-diastolic blood pressure left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricular blood pressure trait male 266 days-280 days 32 10 min mean continuous mean 5.96 mmHg 0.84 4.75 vascular transducer tipped catheter 0.0 lad occlusion 210 days 100326 2460
WKY E/A wave ratio left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. blood flow trait male 238 days-252 days 20 1.61 null 0.21 0.94 echocardiography 0.0 lad occlusion 196 days 100355 2460
SS-Chr 9BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 13 -9.41 mmHg 2.27 8.17 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50805 481
SS-Chr 9BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 14 -8.84 mmHg 1.27 4.74 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50808 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 4 -9.46 mmHg 3.26 6.51 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50813 481
Hsd:SD plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 12 8.82 ng/ml/h 1.04 3.62 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50896 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 21.19 beats/min 4.88 10.9 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50907 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 6 1.39 mEq/d 0.12 0.29 flame atomic emission spectrometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51045 481
FHH/EurMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 8 0.89 mEq/d 0.23 0.64 flame atomic emission spectrometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51050 481
GH/OmrMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 3 -15.69 mmHg 7.96 13.79 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50629 481
Hsd:SD urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 16 0.74 mEq/d 0.11 0.43 flame atomic emission spectrometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51399 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 4 1.66 ml/min 0.1 0.2 urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51447 481
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 6 0.3 mg/dl 0.06 0.15 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51538 481
SS-Chr 16BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 5 1.27 ml/min 0.09 0.19 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51543 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 -3.09 mmHg 3.77 9.23 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51065 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 2.47 beats/min 9.71 25.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51087 481
F344/DuCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 7 15.17 ng/ml/h 1.06 2.81 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50414 481
F344/DuCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 8 10.84 ng/ml/h 1.35 3.83 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50416 481
LEW/Crl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 9 1.5 mEq/d 0.11 0.34 flame atomic emission spectrometry 0 50438 481
SS-Chr 16BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 10 386.76 beats/min 11.54 36.49 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51248 481
GH/OmrMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 375.94 beats/min 11.06 31.28 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51251 481
GH/OmrMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 3 1.36 mEq/d 0.12 0.21 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51268 481
F344/DuCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 9 109.83 mmHg 2.62 7.87 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51734 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 127.98 mmHg 2.2 6.22 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51825 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 10 130.93 mmHg 4.07 12.88 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51826 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 10 121.77 mmHg 0.93 2.94 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51829 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 3 97.79 mmHg 9.11 15.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51831 481
LEW/Crl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 -10.73 mmHg 2.75 6.14 vascular fluid filled catheter 0 51915 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days-94 days 12 serial mean 142.0 mmHg 5.0 17.32 vascular indwelling catheter method left femoral artery 0 0 65467 151
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 93 days 12 serial mean 427.0 beats/min 6.0 20.78 vascular indwelling catheter method left femoral artery 0 0 65469 151
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 4 1.51 ml/min 0.23 0.45 urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51448 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 15 3.44 beats/min 4.53 17.54 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50977 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 12 -0.36 mmHg 1.59 5.52 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51000 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 14 -2.46 mmHg 2.3 8.59 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51001 481
GH/OmrMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 7 4.42 ng/ml/h 0.57 1.51 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51009 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 4 7.2 ng/ml/h 1.34 2.68 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51013 481
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 12 1.26 ml/min 0.24 0.84 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51052 481
GH/OmrMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 8 1.29 ml/min 0.23 0.66 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51058 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 -7.12 mmHg 7.1 18.77 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50763 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 3.0 mmHg 6.88 16.84 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50767 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 15 -12.57 mmHg 1.76 6.83 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50801 481
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.37 mg/dl 0.02 0.05 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51174 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 9 0.29 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51178 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 8 0.33 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51180 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 3 388.81 beats/min 6.13 10.62 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51255 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 3 0.8 ml/min 0.26 0.45 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51064 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 -6.87 beats/min 2.38 6.72 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51092 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 1 68.68 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51097 481
GH/OmrMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 8 1.3 mEq/d 0.09 0.26 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51522 481
SS-Chr 9BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 16 1.32 mEq/d 0.12 0.49 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51523 481
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.35 mg/dl 0.01 0.03 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51536 481
SS-Chr 18BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 6 1.92 ml/min 0.12 0.28 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51540 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 7 1.08 ml/min 0.08 0.2 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51544 481
GH/OmrMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 3 1.69 ml/min 0.06 0.1 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51545 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 5 1.42 ml/min 0.18 0.41 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51550 481
SS-Chr 20BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 13 440.55 beats/min 8.86 31.96 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50879 481
F344/DuCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 5 1.04 ml/min 0.2 0.44 urine creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51257 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 11 0.78 mEq/d 0.1 0.33 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51271 481
Hsd:SD plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 13 0.34 mg/dl 0.01 0.04 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51278 481
BN/NHsdMcwi plasma triglyceride level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood triglyceride amount female 92 days-94 days 7 0.72 mmol/l 0.11 0.3 plasma triglyceride analysis 0.0 0 67291 151
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 18.29 beats/min 7.47 18.3 vascular fluid filled catheter 0 52067 481
Crl:CD(SD) plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 6 0.32 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51984 481
F344/DuCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 5 0.29 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51985 481
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 5 3.3 ng/ml/h 0.43 0.97 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50568 481
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 4 12.93 ng/ml/h 1.15 2.3 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50571 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 -4.07 mmHg 2.8 6.86 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50628 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 10 -13.4 mmHg 2.93 9.26 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50630 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 15 2.88 ng/ml/h 0.5 1.95 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50388 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 9 3.86 ng/ml/h 0.51 1.54 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50395 481
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (0.5 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 141.7 mmHg 7.4 26.68 vascular indwelling catheter method left femoral artery 120.0 0 69536 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 159.0 mmHg 6.4 23.08 vascular indwelling catheter method left femoral artery 120.0 0 69538 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 16 serial mean 118.6 mmHg 3.4 13.6 vascular indwelling catheter method left femoral artery 120.0 0 69543 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 9 serial mean 134.7 mmHg 7.4 22.2 vascular indwelling catheter method left femoral artery 120.0 0 69544 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 9 serial mean 159.1 mmHg 6.4 19.2 vascular indwelling catheter method left femoral artery 120.0 0 69550 151
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood creatinine amount female 92 days-94 days 11 1.05 mg/dl 0.23 0.76 plasma creatinine analysis 0.0 0 urine potassium analysis umol/min 69486 151
WKY heart weight to tibia length ratio left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart mass male 266 days-280 days 16 0.4 g/cm 0.1 0.4 post excision weight measurement 0.0 lad occlusion 210 days 100283 2460
WKY tibia length left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. tibia length male 266 days-280 days 32 4.3 cm 0.09 0.51 post excision length measurement 0.0 lad occlusion 210 days 100287 2460
WKY ejection fraction left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. cardiac output trait male 266 days-280 days 32 40.5 % 2.4 13.58 echocardiography 0.0 lad occlusion 210 days 100302 2460
WKY artery tunica media width to artery inner diameter ratio left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. kidney blood vessel morphology trait male 238 days-252 days 15 1.56 null 0.1 0.39 ex vivo light microscopy with histochemistry and digital image analysis 0.0 lad occlusion 196 days 100387 2460
WKY diastolic blood pressure left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. arterial blood pressure trait male 266 days-280 days 16 10 min mean continuous mean 53.0 mmHg 5.2 20.8 vascular transducer tipped catheter 0.0 lad occlusion 210 days 100319 2460
WKY left ventricular end-diastolic blood pressure left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricular blood pressure trait male 266 days-280 days 16 10 min mean continuous mean 9.36 mmHg 1.62 6.48 vascular transducer tipped catheter 0.0 lad occlusion 210 days 100325 2460
WKY serum sodium level left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. blood sodium amount male 266 days-280 days 16 153.5 mmol/l 2.1 8.4 automated serum sodium test 0.0 lad occlusion 210 days 100331 2460
WKY heart left ventricle end-diastolic diameter left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle end-diastolic diameter male 238 days-252 days 20 10.6 mm 0.2 0.89 echocardiography 0.0 lad occlusion 196 days 100340 2460
WKY/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 113.96 mmHg 3.81 9.34 vascular fluid filled catheter 0 50839 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 18 -22.81 mmHg 3.9 16.57 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50627 481
SS-Chr 20BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 13 -11.14 mmHg 2.22 8.02 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50802 481
SS-Chr 16BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 4 1.14 ml/min 0.06 0.13 urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51450 481
GH/OmrMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 10 1.06 mEq/d 0.11 0.35 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51518 481
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 15 1.61 ml/min 0.19 0.75 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51541 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 1.5 days) then controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 96 days 24 continuous mean 141.0 mmHg 5.0 24.49 vascular indwelling catheter method femoral artery 10800.0 0 left femoral artery 12038 229
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 9 -5.94 mmHg 2.7 8.1 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51068 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 10 5.72 beats/min 7.43 23.5 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51093 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 10 17.17 beats/min 7.37 23.3 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51096 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 8 9.13 ng/ml/h 0.66 1.87 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50396 481
WKY/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 9 1.07 mEq/d 0.08 0.24 flame atomic emission spectrometry 0 50436 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 383.32 beats/min 7.64 20.22 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51243 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 1 432.84 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51254 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 9 1.23 mEq/d 0.15 0.45 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51276 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 12 0.31 mg/dl 0.01 0.04 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51310 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 15 131.99 mmHg 3.79 14.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51997 481
LEW/Crl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 5 1.64 ml/min 0.16 0.36 urine creatinine analysis 0 52028 481
WKY heart left ventricle infarction size to total heart left ventricle size ratio left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle integrity trait male 266 days-280 days 16 31.8 % 10.1 40.4 ex vivo microscopy with digital image analysis 0.0 lad occlusion 210 days 100265 2460
WKY lung wet weight left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. lung mass male 238 days-252 days 20 2.24 g 0.19 0.85 post excision weight measurement 0.0 lad occlusion 196 days 100298 2460
WKY timed urine volume left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. urine output male 238 days-252 days 7 11.4 ml/d 2.4 6.35 urine volume measurement method 0.0 lad occlusion 196 days 100375 2460
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) then tactile electric shock exposure (2 %) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days-94 days 14 serial mean 16.0 mmHg 3.0 11.22 vascular indwelling catheter method left femoral artery 0 0 66149 151
LEW/Crl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 4 -23.46 beats/min 11.46 22.92 vascular fluid filled catheter 0 52066 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 2 1.95 ng/ml/h 0.95 1.34 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50566 481
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 6 2.26 ng/ml/h 0.6 1.47 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50570 481
Crl:CD(SD) heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 402.53 beats/min 6.39 15.65 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50576 481
Crl:CD(SD) heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 425.43 beats/min 14.64 32.74 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50578 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 -25.11 mmHg 3.07 8.68 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50631 481
F344/DuCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 8 0.25 mg/dl 0.01 0.02 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51987 481
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 130.75 mmHg 7.93 17.73 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 51996 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 156.06 mmHg 6.95 17.02 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52002 481
SS-Chr 9BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 14 123.13 mmHg 1.84 6.88 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52004 481
WKY/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 9 1.5 ml/min 0.15 0.45 urine creatinine analysis 0 52027 481
WKY/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 5 0.94 ml/min 0.17 0.39 urine creatinine analysis 0 52030 481
Hsd:SD mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 14 108.56 mmHg 1.93 7.23 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51789 481
GH/OmrMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 3 140.54 mmHg 14.06 24.36 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51823 481
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 10 123.09 mmHg 2.44 7.73 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51824 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 1 112.16 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51830 481
LEW/Crl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 4 -4.69 mmHg 2.7 5.4 vascular fluid filled catheter 0 51916 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days-94 days 14 serial mean 89.0 mmHg 2.0 7.48 vascular indwelling catheter method left femoral artery 0 0 65466 151
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 93 days 14 serial mean 395.0 beats/min 7.0 26.19 vascular indwelling catheter method left femoral artery 0 0 65468 151
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 13 25.74 beats/min 10.93 39.41 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50978 481
GH/OmrMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 9 4.64 beats/min 5.39 16.16 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50979 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 12.15 beats/min 5.65 13.83 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50982 481
SS-Chr 9BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 14 10.17 beats/min 8.23 30.81 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50984 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 12 1.15 ng/ml/h 0.27 0.94 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51003 481
SS-Chr 9BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 11 0.91 ng/ml/h 0.18 0.59 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51007 481
SS-Chr 9BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 14 2.21 ng/ml/h 0.35 1.3 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51010 481
SHR/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 5 0.83 ml/min 0.17 0.38 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51057 481
SS-Chr 20BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 10 1.2 ml/min 0.12 0.38 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51061 481
Crl:CD(SD) creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 3 1.5 ml/min 0.2 0.34 urine creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51258 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.25 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51309 481
GH/OmrMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 10 0.36 mg/dl 0.02 0.06 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51312 481
SS-Chr 9BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 12 0.3 mg/dl 0.01 0.04 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51314 481
GH/OmrMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 8 0.31 mg/dl 0.02 0.06 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51316 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 4 0.25 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51320 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 3 0.3 mg/dl 0.02 0.04 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51322 481
Crl:CD(SD) urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 9 1.68 mEq/d 0.25 0.74 flame atomic emission spectrometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51364 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 5 393.13 beats/min 12.55 28.06 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51380 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 432.9 beats/min 8.18 21.65 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51381 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 3.43 beats/min 11.16 29.52 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51086 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 -4.01 beats/min 12.94 31.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51089 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 -2.86 beats/min 5.12 13.54 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51095 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 3 465.42 beats/min 20.72 35.89 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51383 481
SS-Chr 16BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 7 368.95 beats/min 11.17 29.55 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51384 481
FHH/EurMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 6 1.5 ml/min 0.12 0.3 urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51449 481
SS-Chr 9BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 16 1.23 mEq/d 0.16 0.63 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51520 481
FHH/EurMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 5 0.8 mEq/d 0.21 0.46 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51526 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 5 0.28 mg/dl 0.06 0.14 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51533 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 4 0.35 mg/dl 0.02 0.03 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51534 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 -3.43 mmHg 1.25 2.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50804 481
GH/OmrMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 8 -6.61 mmHg 7.53 21.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50807 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 -15.3 mmHg 6.88 16.84 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50809 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 15 386.98 beats/min 5.77 22.33 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50878 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 357.13 beats/min 8.47 20.75 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50883 481
GH/OmrMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 8 393.96 beats/min 5.0 14.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50884 481
Hsd:SD plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 8 6.46 ng/ml/h 0.58 1.64 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50895 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 5 10.88 beats/min 6.24 13.95 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50904 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 12.14 beats/min 6.37 16.86 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50906 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 15 0.39 mg/dl 0.06 0.21 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51172 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 7 0.28 mg/dl 0.01 0.03 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51173 481
SHR/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 7 355.95 beats/min 5.94 15.72 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51252 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 5 -8.98 mmHg 4.38 9.8 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50762 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 -11.26 mmHg 2.11 5.58 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50766 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 7 10.95 ng/ml/h 1.24 3.28 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50391 481
GH/OmrMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 3 7.09 ng/ml/h 3.05 5.29 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50392 481
LEW/Crl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.32 mg/dl 0.02 0.05 radioimmunoassay 0 50410 481
Crl:CD(SD) plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 2 5.07 ng/ml/h 0.24 0.33 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50415 481
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 126.0 mmHg 4.1 14.78 vascular indwelling catheter method left femoral artery 120.0 0 69528 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 160.2 mmHg 3.5 12.62 vascular indwelling catheter method left femoral artery 120.0 0 69534 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (0.5 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 120.4 mmHg 5.3 24.29 vascular indwelling catheter method left femoral artery 120.0 0 69535 151
SS/JrHsdMcwi urine creatinine excretion rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 92 days-94 days 16 0.0 mg/d 0.0 0.0 urine creatinine analysis 0.0 0 mg/min 69478 151
BN/NHsdMcwi creatinine clearance controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. glomerular filtration trait female 92 days-94 days 8 1.1 ml/min 0.2 0.57 urine creatinine analysis 0.0 0 mg/min 69479 151
WKY heart left ventricle infarction size to total heart left ventricle size ratio left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle integrity trait male 238 days-252 days 20 35.2 % 4.5 20.12 ex vivo microscopy with digital image analysis 0.0 lad occlusion 196 days 100263 2460
WKY heart weight left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart mass male 266 days-280 days 16 1.88 g 0.61 2.42 post excision weight measurement 0.0 lad occlusion 210 days 100280 2460
WKY heart left ventricle weight left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle mass male 266 days-280 days 32 0.93 g 0.1 0.54 post excision weight measurement 0.0 lad occlusion 210 days 100293 2460
WKY right kidney wet weight left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. kidney mass male 238 days-252 days 15 1.37 g 0.04 0.14 post excision weight measurement 0.0 lad occlusion 196 days 100372 2460
WKY kidney fibrotic lesion area to total kidney area ratio left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. kidney integrity trait male 238 days-252 days 15 0.48 % 0.11 0.43 ex vivo light microscopy with histochemistry and digital image analysis 0.0 lad occlusion 196 days 100384 2460
WKY systolic blood pressure left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. arterial blood pressure trait male 266 days-280 days 16 10 min mean continuous mean 79.5 mmHg 5.1 20.4 vascular transducer tipped catheter 0.0 lad occlusion 210 days 100316 2460
WKY systolic blood pressure left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. arterial blood pressure trait male 266 days-280 days 32 10 min mean continuous mean 75.1 mmHg 2.4 13.58 vascular transducer tipped catheter 0.0 lad occlusion 210 days 100317 2460
WKY diastolic blood pressure left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. arterial blood pressure trait male 266 days-280 days 32 10 min mean continuous mean 47.6 mmHg 2.7 15.27 vascular transducer tipped catheter 0.0 lad occlusion 210 days 100320 2460
WKY left ventricular end-systolic blood pressure left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricular blood pressure trait male 266 days-280 days 32 10 min mean continuous mean 67.5 mmHg 3.9 22.06 vascular transducer tipped catheter 0.0 lad occlusion 210 days 100323 2460
WKY maximum rate of positive change in left ventricular blood pressure left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricular blood pressure trait male 266 days-280 days 16 10 min mean continuous mean 2912.0 mmHg/s 300.0 1200.0 vascular transducer tipped catheter 0.0 lad occlusion 210 days 100328 2460
WKY heart left ventricle end-systolic diameter left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle end-systolic diameter male 238 days-252 days 20 9.0 mm 0.2 0.89 echocardiography 0.0 lad occlusion 196 days 100343 2460
WKY heart left ventricle fractional shortening left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle end-diastolic diameter male 238 days-252 days 20 15.1 % 1.0 4.47 echocardiography 0.0 lad occlusion 196 days 100349 2460
WKY right kidney wet weight left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. kidney mass male 238 days-252 days 15 1.37 g 0.04 0.14 post excision weight measurement 0.0 lad occlusion 196 days 100358 2460
WKY timed urine volume left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. urine output male 238 days-252 days 7 11.4 ml/d 2.4 6.35 urine volume measurement method 0.0 lad occlusion 196 days 100361 2460
SS-Chr 18BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 4 0.79 mEq/d 0.09 0.17 flame atomic emission spectrometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51048 481
SS-Chr 20BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 10 1.13 ml/min 0.15 0.46 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51053 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 18 383.68 beats/min 7.38 31.32 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51245 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 9 1.32 mEq/d 0.09 0.28 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51273 481
SS-Chr 18BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.29 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51313 481
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 7 2.5 ng/ml/h 0.55 1.46 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50387 481
SS-Chr 16BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 5 5.67 ng/ml/h 1.28 2.87 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50390 481
LEW/Crl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 4 0.32 mg/dl 0.01 0.03 radioimmunoassay 0 50411 481
SS/JrHsdMcwi plasma triglyceride level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood triglyceride amount female 92 days-94 days 11 1.4 mmol/l 0.21 0.71 plasma triglyceride analysis 0.0 0 67292 151
BN/NHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 19 serial mean 22.0 mmHg 3.0 13.08 vascular indwelling catheter method left femoral artery 0.0 0 67301 151
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 -14.79 mmHg 5.52 16.56 vascular fluid filled catheter 0 51914 481
Crl:CD(SD) plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 3 0.33 mg/dl 0.02 0.03 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51986 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 92 days-94 days 14 0.56 mEq/d 0.06 0.21 unspecified method 0.0 0 urine sodium analysis umol/min 69469 151
BN/NHsdMcwi urine creatinine level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 92 days-94 days 25 56.4 mg/dl 4.95 24.75 urine creatinine analysis 0.0 0 69475 151
BN/NHsdMcwi urine creatinine excretion rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 92 days-94 days 25 0.0 mg/d 0.0 0.0 urine creatinine analysis 0.0 0 mg/min 69477 151
SS/JrHsdMcwi white blood cell count controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. leukocyte quantity female 92 days-94 days 9 0.01 x 1000 cells/ul 1044.0 3132.0 isolated cell counting method 0.0 0 69496 151
WKY heart weight to tibia length ratio left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart mass male 266 days-280 days 32 0.31 g/cm 0.04 0.23 post excision weight measurement 0.0 lad occlusion 210 days 100284 2460
WKY heart left ventricle weight left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle mass male 238 days-252 days 20 0.96 g 0.12 0.53 post excision weight measurement 0.0 lad occlusion 196 days 100289 2460
WKY heart left ventricle weight to tibia length ratio left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle mass male 266 days-280 days 16 0.24 g/cm 0.03 0.12 post excision weight measurement 0.0 lad occlusion 210 days lv/tl 100295 2460
WKY heart left ventricle end-diastolic diameter left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle end-diastolic diameter male 266 days-280 days 32 10.6 mm 0.3 1.7 echocardiography 0.0 lad occlusion 210 days 100308 2460
FHH/EurMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 116.75 mmHg 1.54 4.07 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51820 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 18 135.0 mmHg 5.04 21.4 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51821 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 7 117.77 mmHg 2.86 7.56 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51828 481
Crl:CD(SD) mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 108.62 mmHg 3.76 9.22 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51731 481
Crl:CD(SD) mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 101.2 mmHg 3.26 7.28 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51733 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (0.4 %) (for 35 days) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renin activity female 95 days 7 4.7 ng/ml/h 1.6 4.23 ex vivo blood analysis 0 0 65473 151
SS-Chr 20BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 18 1.0 mEq/d 0.12 0.49 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51517 481
SS-Chr 20BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 18 1.11 mEq/d 0.13 0.54 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51525 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 9 1.05 mEq/d 0.12 0.36 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51528 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 4 0.28 mg/dl 0.02 0.04 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51539 481
FHH/EurMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 9 2.23 ml/min 0.08 0.25 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51547 481
Hsd:SD urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 20 1.19 mEq/d 0.1 0.46 flame atomic emission spectrometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51398 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 12 20.86 beats/min 10.81 37.45 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51400 481
SS-Chr 16BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 5 1.54 ml/min 0.24 0.55 urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51452 481
SS-Chr 16BN/Mcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 7 0.35 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51177 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 2 0.26 mg/dl 0.06 0.08 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 51179 481
GH/OmrMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 3 407.56 beats/min 2.82 4.89 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51247 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 10 407.56 beats/min 6.03 19.06 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51250 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 10 399.95 beats/min 7.51 23.75 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51253 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 6 -15.47 mmHg 6.08 14.9 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50806 481
Hsd:SD heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 14 428.56 beats/min 6.77 25.34 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50815 481
SS-Chr 18BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 409.57 beats/min 5.76 12.88 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50881 481
SS-Chr 9BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 13 395.28 beats/min 9.37 33.79 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50882 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 3 15.12 beats/min 28.47 49.3 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50908 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 18.95 beats/min 7.34 17.98 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51260 481
SS-Chr 16BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 10 1.62 mEq/d 0.15 0.47 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51269 481
FHH/EurMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 10 2.11 mEq/d 0.17 0.54 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51274 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 5 105.29 mmHg 2.43 5.43 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51323 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 3 107.87 mmHg 1.27 2.21 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51327 481
Crl:CD(SD) urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 9 1.82 mEq/d 0.27 0.81 flame atomic emission spectrometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51362 481
F344/DuCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 8 1.25 mEq/d 0.19 0.54 flame atomic emission spectrometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51363 481
F344/DuCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 10 1.24 mEq/d 0.13 0.4 flame atomic emission spectrometry 0 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51365 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 6 17.34 beats/min 5.18 12.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50985 481
SS-Chr 20BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 11 3.37 ng/ml/h 0.66 2.2 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51004 481
SHR/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 6 3.33 ng/ml/h 0.45 1.11 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51011 481
SS-Chr 16BN/Mcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 8 1.07 mEq/d 0.18 0.5 flame atomic emission spectrometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51049 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) then tactile electric shock exposure (2 %) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92 days-94 days 8 serial mean 11.0 mmHg 3.0 8.49 vascular indwelling catheter method left femoral artery 0 0 66150 151
FHH/EurMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 6 11.87 ng/ml/h 0.85 2.08 radioimmunoassay 0 Moms and pups used in studies were fed Dyets 50389 481
WKY/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 9 0.4 mg/dl 0.02 0.06 radioimmunoassay 0 50409 481
Crl:CD(SD) plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87 days-120 days 5 5.64 ng/ml/h 1.41 3.16 radioimmunoassay 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50413 481
LEW/Crl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 7 1.07 mEq/d 0.15 0.39 flame atomic emission spectrometry 0 50437 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 1.5 days) then controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 96 days 21 continuous mean 96.0 mmHg 3.0 13.75 vascular indwelling catheter method femoral artery 10800.0 0 left femoral artery 13275 229
SS/JrHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 9 serial mean 24.0 mmHg 4.0 12.0 vascular indwelling catheter method left femoral artery 0.0 0 67304 151
SS-Chr 18BN/Mcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 2 1.29 ng/ml/h 0.49 0.69 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50569 481
F344/DuCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 9 410.92 beats/min 6.97 20.92 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50577 481
F344/DuCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 9 413.17 beats/min 9.33 28.0 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50579 481
LEW/Crl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87 days-120 days 5 4.91 ng/ml/h 0.65 1.44 radioimmunoassay 0 51958 481
SS/JrHsdMcwi plasma total cholesterol level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood cholesterol amount female 92 days-94 days 12 76.0 mg/dl 4.4 15.24 plasma total cholesterol measurement test 0.0 0 67290 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (20 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 20 serial mean 118.9 mmHg 4.4 19.68 vascular indwelling catheter method left femoral artery 120.0 0 69529 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (20 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 131.3 mmHg 4.2 15.14 vascular indwelling catheter method left femoral artery 120.0 0 69530 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 21 serial mean 128.6 mmHg 4.0 18.33 vascular indwelling catheter method left femoral artery 120.0 0 69537 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 20 serial mean 135.6 mmHg 3.2 14.31 vascular indwelling catheter method left femoral artery 120.0 0 69539 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 13 serial mean 168.4 mmHg 7.0 25.24 vascular indwelling catheter method left femoral artery 120.0 0 69540 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101 days-103 days 9 serial mean 159.0 mmHg 7.1 21.3 vascular indwelling catheter method left femoral artery 120.0 0 69546 151
BN/NHsdMcwi timed urine volume controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine output female 92 days-94 days 25 9.86 ml/d 0.4 2.0 urine volume measurement method 0.0 0 needs ml/d default 69464 151
SS/JrHsdMcwi urine sodium level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 92 days-94 days 14 149.5 mmol/l 5.2 19.46 unspecified method 0.0 0 urine sodium analysis 69467 151
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 92 days-94 days 22 0.46 mEq/d 0.03 0.13 unspecified method 0.0 0 urine sodium analysis umol/min 69468 151
BN/NHsdMcwi urine potassium excretion rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine potassium amount female 92 days-94 days 22 0.88 mEq/d 0.06 0.27 unspecified method 0.0 0 urine potassium analysis umol/min 69473 151
SS/JrHsdMcwi urine creatinine level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 92 days-94 days 17 111.7 mg/dl 10.5 43.29 urine creatinine analysis 0.0 0 69476 151
BN/NHsdMcwi plasma high density lipoprotein cholesterol level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood HDL cholesterol amount female 92 days-94 days 9 44.2 mg/dl 2.2 6.6 plasma high-density lipoprotein-cholesterol measurement test 0.0 0 69503 151
WKY body weight left anterior descending coronary artery occlusion then furosemide Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. body mass male 42 days-56 days 20 225.0 g 3.0 13.42 body weighing method 0.0 lad occlusion 0 days 100268 2460
WKY body weight left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. body mass male 238 days-252 days 20 583.0 g 56.0 250.44 body weighing method 0.0 lad occlusion 196 days 100271 2460
WKY heart left ventricle weight to tibia length ratio left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle mass male 266 days-280 days 32 0.21 g/cm 0.02 0.11 post excision weight measurement 0.0 lad occlusion 210 days 100296 2460
WKY heart left ventricle fractional shortening left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle end-diastolic diameter male 266 days-280 days 16 16.8 % 1.6 6.4 echocardiography 0.0 lad occlusion 210 days 100304 2460
WKY heart left ventricle fractional shortening left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle end-diastolic diameter male 266 days-280 days 32 18.0 % 1.5 8.49 echocardiography 0.0 lad occlusion 210 days 100305 2460
WKY heart left ventricle end-diastolic diameter left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle end-diastolic diameter male 266 days-280 days 16 10.8 mm 0.3 1.2 echocardiography 0.0 lad occlusion 210 days 100307 2460
WKY heart left ventricle end-systolic diameter left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle end-systolic diameter male 266 days-280 days 32 8.8 mm 0.3 1.7 echocardiography 0.0 lad occlusion 210 days 100311 2460
WKY left ventricular end-systolic blood pressure left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricular blood pressure trait male 266 days-280 days 16 10 min mean continuous mean 73.5 mmHg 4.7 18.8 vascular transducer tipped catheter 0.0 lad occlusion 210 days 100322 2460
WKY plasma creatinine level left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. blood creatinine amount male 238 days-252 days 6 0.47 mg/dl 0.03 0.07 plasma creatinine analysis 0.0 lad occlusion 196 days 100364 2460
SS-Chr 9BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 12 0.79 ml/min 0.17 0.6 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51056 481
SS-Chr 9BN/Mcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 12 0.56 ml/min 0.15 0.53 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51059 481
FHH/EurMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 4 1.21 ml/min 0.21 0.42 urine creatinine analysis 0 Moms and pups used in studies were fed Teklad 51062 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 10 -17.53 mmHg 2.45 7.75 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 50632 481
Crl:CD(SD) creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 6 2.46 ml/min 0.22 0.54 urine creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51256 481
F344/DuCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 8 0.92 ml/min 0.08 0.22 urine creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51259 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 5 0.36 beats/min 7.52 16.81 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51262 481
FHH/EurMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87 days-120 days 8 1.74 mEq/d 0.27 0.76 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 51265 481
SHR/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 5 0.29 mg/dl 0.01 0.02 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51318 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87 days-120 days 3 0.29 mg/dl 0.0 0.01 radioimmunoassay 0 Moms and pups used in studies were fed Teklad 51321 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 5 117.49 mmHg 2.54 5.67 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51324 481
FHH/EurMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 412.44 beats/min 11.88 29.1 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51385 481
GH/OmrMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 3 -11.72 beats/min 10.1 17.5 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51090 481
WKY/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 9 103.89 mmHg 5.5 16.51 vascular fluid filled catheter 0 50836 481
SS-Chr 9BN/Mcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87 days-120 days 14 429.17 beats/min 4.83 18.06 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 50885 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 6 4.58 beats/min 3.9 9.56 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50910 481
FHH/EurMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87 days-120 days 4 1.77 ml/min 0.13 0.26 urine creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51453 481
SHR/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 8 1.08 mEq/d 0.16 0.45 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51521 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87 days-120 days 10 1.17 mEq/d 0.16 0.49 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Teklad 51527 481
FHH/EurMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87 days-120 days 6 0.27 mg/dl 0.01 0.02 radioimmunoassay 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51535 481
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87 days-120 days 8 1.36 ml/min 0.12 0.35 urine creatinine analysis 0 Moms and pups used in studies were fed Dyets 51549 481
LEW/Crl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87 days-120 days 4 352.38 beats/min 10.21 20.42 vascular fluid filled catheter 0 51782 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87 days-120 days 7 119.18 mmHg 4.9 12.98 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 51819 481
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 5 117.87 mmHg 3.37 7.54 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52000 481
SHR/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87 days-120 days 6 137.69 mmHg 5.58 13.68 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 52005 481
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. glomerular filtration trait female 92 days-94 days 10 1.08 ml/min 0.37 1.17 urine creatinine analysis 0.0 0 mg/min 69480 151
WKY plasma creatinine level left anterior descending coronary artery occlusion (for 196 days) then furosemide (10 ml/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. blood creatinine amount male 238 days-252 days 6 0.47 mg/dl 0.03 0.07 plasma creatinine analysis 0.0 lad occlusion 196 days 100378 2460
WKY heart weight left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart mass male 266 days-280 days 32 1.44 g 0.37 2.09 post excision weight measurement 0.0 lad occlusion 210 days 100281 2460
WKY tibia length left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. tibia length male 266 days-280 days 16 4.3 cm 0.09 0.36 post excision length measurement 0.0 lad occlusion 210 days 100286 2460
WKY maximum rate of positive change in left ventricular blood pressure left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricular blood pressure trait male 266 days-280 days 32 10 min mean continuous mean 2882.0 mmHg/s 208.0 1176.63 vascular transducer tipped catheter 0.0 lad occlusion 210 days 100329 2460
WKY serum sodium level left anterior descending coronary artery occlusion (for 224 days) then furosemide (10 mg/kg/d) (for 161 days) then ramipril (1 mg/kg/d) (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. blood sodium amount male 266 days-280 days 32 155.1 mmol/l 1.1 6.22 automated serum sodium test 0.0 lad occlusion 210 days 100332 2460