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PhenoMiner Database Result        View data table  |  Download data table  |  View expanded data table        


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Rat Strains

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# of AnimalsPhenotypeStrainSexValueUnitsConditionsRecord IDCondition 1Condition 2Condition 3aCondition 3b
11heart weight to body weight ratioWKYmale2.4g/kgunilateral nephrectomy (for 150 days) then vehicle control condition107450unilateral nephrectomy (for 150 days)vehicle control condition
17heart weight to body weight ratioWKYmale3.5g/kgunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition107451unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) vehicle control condition
17heart weight to body weight ratioWKYmale3.2g/kgunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days)107452unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 136 days)
16heart weight to body weight ratioWKYmale3.1g/kgunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days)107453unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)
16heart weight to body weight ratioWKYmale3.1g/kgunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days)107454unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)bosentan (100 mg/kg/d) (for 136 days)
11kidney glomerular surface areaWKYmale12.6x 10E3 um2unilateral nephrectomy (for 150 days) then vehicle control condition107460unilateral nephrectomy (for 150 days)vehicle control condition
17kidney glomerular surface areaWKYmale19.3x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition107461unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) vehicle control condition
17kidney glomerular surface areaWKYmale17x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days)107462unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 136 days)
16kidney glomerular surface areaWKYmale15.8x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days)107463unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)
16kidney glomerular surface areaWKYmale16.4x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days)107464unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)bosentan (100 mg/kg/d) (for 136 days)
11kidney glomerular tuft surface areaWKYmale8.7x 10E3 um2unilateral nephrectomy (for 150 days) then vehicle control condition107510unilateral nephrectomy (for 150 days)vehicle control condition
17kidney glomerular tuft surface areaWKYmale13.2x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition107511unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) vehicle control condition
17kidney glomerular tuft surface areaWKYmale11.8x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days)107512unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 136 days)
16kidney glomerular tuft surface areaWKYmale11.1x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days)107513unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)
16kidney glomerular tuft surface areaWKYmale11.7x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days)107514unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)bosentan (100 mg/kg/d) (for 136 days)
11left kidney wet weight to body weight ratioWKYmale3.9mg/gunilateral nephrectomy (for 150 days) then vehicle control condition107455unilateral nephrectomy (for 150 days)vehicle control condition
17left kidney wet weight to body weight ratioWKYmale9.9mg/gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition107456unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) vehicle control condition
17left kidney wet weight to body weight ratioWKYmale8.2mg/gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days)107457unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 136 days)
16left kidney wet weight to body weight ratioWKYmale8.1mg/gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days)107458unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)
16left kidney wet weight to body weight ratioWKYmale8.3mg/gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days)107459unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)bosentan (100 mg/kg/d) (for 136 days)
7renal vascular resistanceWKYmale10mmHg/ml/minunilateral nephrectomy (for 28 days) then vehicle control condition99960unilateral nephrectomy (for 28 days)vehicle control condition
8renal vascular resistanceWKYmale9mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99961unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
8renal vascular resistanceWKYmale8.8mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days)99962unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 14 days)
8renal vascular resistanceWKYmale9.2mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days)99963unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)
6renal vascular resistanceWKYmale8.8mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days)99964unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)bosentan (100 mg/kg/d) (for 14 days)
11renal vascular resistanceWKYmale6.3mmHg/ml/minunilateral nephrectomy (for 28 days) then vehicle control condition99995unilateral nephrectomy (for 28 days)vehicle control condition
17renal vascular resistanceWKYmale16.7mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99996unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
17renal vascular resistanceWKYmale6.6mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days)99997unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 154 days)
16renal vascular resistanceWKYmale7.1mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days)99998unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)
16renal vascular resistanceWKYmale6.8mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days)99999unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)bosentan (100 mg/kg/d) (for 154 days)
7renal plasma flow to body weight ratioWKYmale2.16ml/min/100gunilateral nephrectomy (for 28 days) then vehicle control condition99950unilateral nephrectomy (for 28 days)vehicle control condition
8renal plasma flow to body weight ratioWKYmale3.09ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99951unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
8renal plasma flow to body weight ratioWKYmale2.33ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days)99952unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 14 days)
8renal plasma flow to body weight ratioWKYmale2.32ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days)99953unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)
6renal plasma flow to body weight ratioWKYmale2.42ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days)99954unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)bosentan (100 mg/kg/d) (for 14 days)
11renal plasma flow to body weight ratioWKYmale2.28ml/min/100gunilateral nephrectomy (for 28 days) then vehicle control condition99990unilateral nephrectomy (for 28 days)vehicle control condition
17renal plasma flow to body weight ratioWKYmale1.72ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99991unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
17renal plasma flow to body weight ratioWKYmale3.3ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days)99992unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 154 days)
16renal plasma flow to body weight ratioWKYmale3.15ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days)99993unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)
16renal plasma flow to body weight ratioWKYmale3.19ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days)99994unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)bosentan (100 mg/kg/d) (for 154 days)
7timed urine volumeWKYmale12.384ml/dunilateral nephrectomy (for 28 days) then vehicle control condition99965unilateral nephrectomy (for 28 days)vehicle control condition
8timed urine volumeWKYmale23.472ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99966unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
8timed urine volumeWKYmale38.016ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days)99967unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 14 days)
8timed urine volumeWKYmale41.616ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days)99968unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)
6timed urine volumeWKYmale44.928ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days)99969unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)bosentan (100 mg/kg/d) (for 14 days)
11timed urine volumeWKYmale11.664ml/dunilateral nephrectomy (for 28 days) then vehicle control condition100000unilateral nephrectomy (for 28 days)vehicle control condition
17timed urine volumeWKYmale39.456ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition100001unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
17timed urine volumeWKYmale41.472ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days)100002unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 154 days)
16timed urine volumeWKYmale45.504ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days)100003unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)
16timed urine volumeWKYmale49.248ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days)100004unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)bosentan (100 mg/kg/d) (for 154 days)
7blood glucose levelWKYmale74mg/dlunilateral nephrectomy (for 28 days) then vehicle control condition99940unilateral nephrectomy (for 28 days)vehicle control condition
8blood glucose levelWKYmale350mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99941unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
8blood glucose levelWKYmale352mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days)99942unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 14 days)
8blood glucose levelWKYmale357mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days)99943unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)
6blood glucose levelWKYmale367mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days)99944unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)bosentan (100 mg/kg/d) (for 14 days)
11blood glucose levelWKYmale76mg/dlunilateral nephrectomy (for 28 days) then vehicle control condition99970unilateral nephrectomy (for 28 days)vehicle control condition
17blood glucose levelWKYmale324mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99971unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
17blood glucose levelWKYmale312mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days)99972unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 154 days)
16blood glucose levelWKYmale308mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days)99973unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)
16blood glucose levelWKYmale317mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days)99974unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)bosentan (100 mg/kg/d) (for 154 days)
7body weightWKYmale268gunilateral nephrectomy (for 28 days) then vehicle control condition99935unilateral nephrectomy (for 28 days)vehicle control condition
8body weightWKYmale215gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99936unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
8body weightWKYmale236gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days)99937unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 14 days)
8body weightWKYmale233gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days)99938unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)
6body weightWKYmale229gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days)99939unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)bosentan (100 mg/kg/d) (for 14 days)
11body weightWKYmale408gunilateral nephrectomy (for 150 days) then vehicle control condition107445unilateral nephrectomy (for 150 days)vehicle control condition
17body weightWKYmale256gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition107446unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) vehicle control condition
17body weightWKYmale274gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days)107447unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 136 days)
16body weightWKYmale261gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days)107448unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)
16body weightWKYmale267gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days)107449unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 136 days)bosentan (100 mg/kg/d) (for 136 days)
7glomerular filtration rate to body weight ratioWKYmale0.494ml/min/100gunilateral nephrectomy (for 28 days) then vehicle control condition99945unilateral nephrectomy (for 28 days)vehicle control condition
8glomerular filtration rate to body weight ratioWKYmale0.792ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99946unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
8glomerular filtration rate to body weight ratioWKYmale0.516ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days)99947unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 14 days)
8glomerular filtration rate to body weight ratioWKYmale0.536ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days)99948unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)
6glomerular filtration rate to body weight ratioWKYmale0.504ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days)99949unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)bosentan (100 mg/kg/d) (for 14 days)
7renal filtration fractionWKYmale0.233unilateral nephrectomy (for 28 days) then vehicle control condition99955unilateral nephrectomy (for 28 days)vehicle control condition
8renal filtration fractionWKYmale0.26unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99956unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
8renal filtration fractionWKYmale0.233unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days)99957unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 14 days)
8renal filtration fractionWKYmale0.234unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days)99958unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)
6renal filtration fractionWKYmale0.21unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days)99959unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 14 days)bosentan (100 mg/kg/d) (for 14 days)
11glomerular filtration rate to body weight ratioWKYmale0.517ml/min/100gunilateral nephrectomy (for 28 days) then vehicle control condition99980unilateral nephrectomy (for 28 days)vehicle control condition
17glomerular filtration rate to body weight ratioWKYmale0.496ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99981unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
17glomerular filtration rate to body weight ratioWKYmale0.69ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days)99982unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 154 days)
16glomerular filtration rate to body weight ratioWKYmale0.664ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days)99983unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)
16glomerular filtration rate to body weight ratioWKYmale0.673ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days)99984unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)bosentan (100 mg/kg/d) (for 154 days)
11renal filtration fractionWKYmale0.23unilateral nephrectomy (for 28 days) then vehicle control condition99985unilateral nephrectomy (for 28 days)vehicle control condition
17renal filtration fractionWKYmale0.293unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99986unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
17renal filtration fractionWKYmale0.214unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days)99987unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 154 days)
16renal filtration fractionWKYmale0.216unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days)99988unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)
16renal filtration fractionWKYmale0.213unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days)99989unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)bosentan (100 mg/kg/d) (for 154 days)
11hematocritWKYmale45.2%unilateral nephrectomy (for 28 days) then vehicle control condition99975unilateral nephrectomy (for 28 days)vehicle control condition
17hematocritWKYmale44.8%unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99976unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
17hematocritWKYmale45.6%unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days)99977unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) bosentan (100 mg/kg/d) (for 154 days)
16hematocritWKYmale45.8%unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days)99978unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)
16hematocritWKYmale44.5%unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days)99979unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) enalapril (10 mg/kg/d) (for 154 days)bosentan (100 mg/kg/d) (for 154 days)