SD |
left kidney wet weight |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney mass |
male |
0 days
| 5 |
1.49 |
g |
0.1 |
0.23 |
post excision weight measurement |
|
0.0 |
unx |
13 |
days |
remnant kidney |
101546 |
2602 |
WKY |
left kidney wet weight to body weight ratio |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
kidney mass |
male |
0 days
| 16 |
8.3 |
mg/g |
0.2 |
0.8 |
post excision weight measurement |
|
0.0 |
unx |
150 |
days |
|
107459 |
2378 |
WKY |
heart weight to body weight ratio |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
heart mass |
male |
0 days
| 16 |
3.1 |
g/kg |
0.1 |
0.4 |
post excision weight measurement |
|
0.0 |
unx |
150 |
days |
|
107454 |
2378 |
SD |
adrenal gland weight |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
adrenal gland mass |
male |
0 days
| 6 |
60.0 |
mg |
3.27 |
8.0 |
post excision weight measurement |
|
0.0 |
unx |
28 |
days |
|
101602 |
2602 |
SD |
adrenal gland weight |
unilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
adrenal gland mass |
male |
0 days
| 8 |
73.0 |
mg |
2.83 |
8.0 |
post excision weight measurement |
|
0.0 |
unx |
28 |
days |
|
101628 |
2602 |
SD |
adrenal gland weight |
unilateral nephrectomy (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
adrenal gland mass |
male |
0 days
| 7 |
69.0 |
mg |
3.4 |
9.0 |
post excision weight measurement |
|
0.0 |
unx |
28 |
days |
|
101600 |
2602 |
SD |
left kidney wet weight |
unilateral nephrectomy (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney mass |
male |
0 days
| 11 |
1.37 |
g |
0.07 |
0.23 |
post excision weight measurement |
|
0.0 |
unx |
13 |
days |
remnant kidney |
101544 |
2602 |
SHR-Chr 8MWF/Rkb |
right kidney wet weight |
unilateral nephrectomy (for 126 days) |
Schulz A, etal., Physiol Genomics. 2012 Jan 18;44(1):110-6. Epub 2011 Nov 22. |
kidney mass |
male |
168 days
| 15 |
1.59 |
g |
0.04 |
0.15 |
post excision weight measurement |
kidney |
0.0 |
|
0 |
|
|
109556 |
3148 |
SHR/FubRkb |
right kidney wet weight to body weight ratio |
unilateral nephrectomy (for 126 days) |
Schulz A, etal., Physiol Genomics. 2012 Jan 18;44(1):110-6. Epub 2011 Nov 22. |
kidney mass |
male |
168 days
| 15 |
5.02 |
mg/g |
0.16 |
0.62 |
post excision weight measurement |
kidney |
0.0 |
|
0 |
|
|
109559 |
3148 |
SHR-Chr 8MWF/Rkb |
right kidney wet weight to body weight ratio |
unilateral nephrectomy (for 126 days) |
Schulz A, etal., Physiol Genomics. 2012 Jan 18;44(1):110-6. Epub 2011 Nov 22. |
kidney mass |
male |
168 days
| 15 |
4.71 |
mg/g |
0.09 |
0.35 |
post excision weight measurement |
kidney |
0.0 |
|
0 |
|
|
109560 |
3148 |
WKY |
heart weight to body weight ratio |
unilateral nephrectomy (for 150 days) then vehicle control condition |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
heart mass |
male |
0 days
| 11 |
2.4 |
g/kg |
0.1 |
0.33 |
post excision weight measurement |
|
0.0 |
unx |
150 |
days |
|
107450 |
2378 |
WKY |
left kidney wet weight to body weight ratio |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
kidney mass |
male |
0 days
| 17 |
9.9 |
mg/g |
0.7 |
2.89 |
post excision weight measurement |
|
0.0 |
unx |
150 |
days |
|
107456 |
2378 |
SD |
left kidney wet weight |
unilateral nephrectomy (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney mass |
male |
0 days
| 8 |
1.96 |
g |
0.16 |
0.44 |
post excision weight measurement |
|
0.0 |
unx |
28 |
days |
|
101613 |
2602 |
SD |
left kidney wet weight |
unilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney mass |
male |
0 days
| 8 |
1.79 |
g |
0.12 |
0.35 |
post excision weight measurement |
|
0.0 |
unx |
28 |
days |
|
101614 |
2602 |
SD |
adrenal gland weight |
unilateral nephrectomy (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
adrenal gland mass |
male |
0 days
| 11 |
63.0 |
mg |
1.21 |
4.0 |
post excision weight measurement |
|
0.0 |
unx |
13 |
days |
- |
101560 |
2602 |
SD |
left kidney wet weight |
unilateral nephrectomy (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney mass |
male |
0 days
| 7 |
1.91 |
g |
0.21 |
0.55 |
post excision weight measurement |
|
0.0 |
unx |
28 |
days |
remnant kidney |
101580 |
2602 |
WKY |
left kidney wet weight to body weight ratio |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
kidney mass |
male |
0 days
| 17 |
8.2 |
mg/g |
0.2 |
0.82 |
post excision weight measurement |
|
0.0 |
unx |
150 |
days |
|
107457 |
2378 |
WKY |
left kidney wet weight to body weight ratio |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
kidney mass |
male |
0 days
| 16 |
8.1 |
mg/g |
0.2 |
0.8 |
post excision weight measurement |
|
0.0 |
unx |
150 |
days |
|
107458 |
2378 |
SD |
heart wet weight |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
heart mass |
male |
0 days
| 7 |
0.88 |
g |
0.04 |
0.11 |
post excision weight measurement |
|
0.0 |
unx |
28 |
days |
|
101589 |
2602 |
SD |
heart wet weight |
unilateral nephrectomy (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
heart mass |
male |
0 days
| 8 |
1.33 |
g |
0.05 |
0.13 |
post excision weight measurement |
|
0.0 |
unx |
28 |
days |
|
101619 |
2602 |
SD |
heart wet weight |
unilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
heart mass |
male |
0 days
| 8 |
1.21 |
g |
0.04 |
0.1 |
post excision weight measurement |
|
0.0 |
unx |
28 |
days |
|
101620 |
2602 |
SD |
adrenal gland weight |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
adrenal gland mass |
male |
0 days
| 7 |
57.0 |
mg |
1.51 |
4.0 |
post excision weight measurement |
|
0.0 |
unx |
28 |
days |
|
101601 |
2602 |
SD |
heart wet weight |
unilateral nephrectomy (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
heart mass |
male |
0 days
| 7 |
1.33 |
g |
0.07 |
0.19 |
post excision weight measurement |
|
0.0 |
unx |
28 |
days |
|
101588 |
2602 |
SD |
heart wet weight |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
heart mass |
male |
0 days
| 6 |
1.28 |
g |
0.05 |
0.12 |
post excision weight measurement |
|
0.0 |
unx |
28 |
days |
|
101590 |
2602 |
WKY |
heart weight to body weight ratio |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
heart mass |
male |
0 days
| 17 |
3.2 |
g/kg |
0.1 |
0.41 |
post excision weight measurement |
|
0.0 |
unx |
150 |
days |
|
107452 |
2378 |
SD |
left kidney wet weight |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney mass |
male |
0 days
| 7 |
1.47 |
g |
0.07 |
0.18 |
post excision weight measurement |
|
0.0 |
unx |
28 |
days |
remnant kidney |
101581 |
2602 |
SD |
adrenal gland weight |
unilateral nephrectomy (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
adrenal gland mass |
male |
0 days
| 8 |
71.0 |
mg |
1.41 |
4.0 |
post excision weight measurement |
|
0.0 |
unx |
28 |
days |
|
101627 |
2602 |
SD |
adrenal gland weight |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
adrenal gland mass |
male |
0 days
| 5 |
56.0 |
mg |
1.79 |
4.0 |
post excision weight measurement |
|
0.0 |
unx |
13 |
days |
|
101561 |
2602 |
SD |
adrenal gland weight |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
adrenal gland mass |
male |
0 days
| 5 |
60.0 |
mg |
3.13 |
7.0 |
post excision weight measurement |
|
0.0 |
unx |
13 |
days |
|
101562 |
2602 |
SD |
left kidney wet weight |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney mass |
male |
0 days
| 6 |
2.03 |
g |
0.2 |
0.48 |
post excision weight measurement |
|
0.0 |
unx |
28 |
days |
remnant kidney |
101582 |
2602 |
SHR/FubRkb |
right kidney wet weight |
unilateral nephrectomy (for 126 days) |
Schulz A, etal., Physiol Genomics. 2012 Jan 18;44(1):110-6. Epub 2011 Nov 22. |
kidney mass |
male |
168 days
| 15 |
1.63 |
g |
0.05 |
0.19 |
post excision weight measurement |
kidney |
0.0 |
|
0 |
|
|
109555 |
3148 |
WKY |
heart weight to body weight ratio |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
heart mass |
male |
0 days
| 17 |
3.5 |
g/kg |
0.1 |
0.41 |
post excision weight measurement |
|
0.0 |
unx |
150 |
days |
|
107451 |
2378 |
WKY |
heart weight to body weight ratio |
unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
heart mass |
male |
0 days
| 16 |
3.1 |
g/kg |
0.1 |
0.4 |
post excision weight measurement |
|
0.0 |
unx |
150 |
days |
|
107453 |
2378 |
WKY |
left kidney wet weight to body weight ratio |
unilateral nephrectomy (for 150 days) then vehicle control condition |
Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. |
kidney mass |
male |
0 days
| 11 |
3.9 |
mg/g |
0.1 |
0.33 |
post excision weight measurement |
|
0.0 |
unx |
150 |
days |
|
107455 |
2378 |
SD |
left kidney wet weight |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney mass |
male |
0 days
| 5 |
1.16 |
g |
0.11 |
0.25 |
post excision weight measurement |
|
0.0 |
unx |
13 |
days |
remnant kidney |
101545 |
2602 |