Phenominer Database Results (351 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
ACI.FHH-(D1Rat324-D1Rat156)/Eur body weight unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. body mass male 173 days-180 days 8 284.0 g 5.0 14.14 body weighing method 0.0 0 67680 751
ACI/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 173 days-180 days 8 5.0 % 1.0 2.83 ex vivo light microscopy with histochemistry 0.0 0 67956 751
ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 173 days-180 days 10 2.0 % 1.0 3.16 ex vivo light microscopy with histochemistry 0.0 0 67957 751
ACI.FHH-(D1Rat324-D1Rat156)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 173 days-180 days 8 9.0 % 3.0 8.49 ex vivo light microscopy with histochemistry 0.0 0 67958 751
ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 173 days-180 days 9 8.0 % 2.0 6.0 ex vivo light microscopy with histochemistry 0.0 0 67960 751
ACI/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy Shiozawa M, et al., J Am Soc Nephrol 2000 Nov;11(11):2068-78. kidney glomerulus integrity trait male 91 days-98 days 21 3.2 % 0.39 1.8 ex vivo light microscopy 0.0 unilateral nephrectomy 39 days performed at 5 to 6 weeks of age 69158 1128
ACI.FHH-(D1Rat384-D1Rat452)(D17Rat61-D1Arb5)(D17Rat51)/Eur body weight unilateral nephrectomy van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. body mass not specified 168 days-175 days 12 304.0 g 4.0 13.86 body weighing method 0.0 unilateral nephrectomy 126 days 67902 832
ACI.FHH-(D1Rat384-D1Rat452)(D17Rat61-D1Arb5)(D17Rat51)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then NG-nitroarginine methyl ester (10-21 mg/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. kidney glomerulus integrity trait not specified 168 days-175 days 9 29.0 % 4.0 12.0 ex vivo light microscopy 0.0 unilateral nephrectomy 126 days Original CMO_ID, CMO:0001176, was merged into current ID and field automatically updated. 4-26-2013 68885 832
SD serum creatinine level controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. blood creatinine amount female 0 days 13 1.65 mg/dl 0.14 0.5 serum creatinine analysis 0.0 unx 97 days 100637 2499
SD serum creatinine level controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days) and enalapril (25 mg/l) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. blood creatinine amount female 0 days 12 0.93 mg/dl 0.05 0.17 serum creatinine analysis 0.0 unx 97 days 100640 2499
SD serum parathyroid hormone level controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. blood parathyroid hormone amount female 0 days 13 3496.0 pg/ml 862.0 3107.99 serum parathyroid hormone analysis 0.0 unx 97 days 100647 2499
SD serum parathyroid hormone level controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days) and enalapril (25 mg/l) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. blood parathyroid hormone amount female 0 days 12 170.0 pg/ml 60.0 207.85 serum parathyroid hormone analysis 0.0 unx 97 days 100650 2499
SHR/NCrlCrlj plasma angiotensin II level to plasma angiotensin I level ratio unilateral nephrectomy (for 42 days) then controlled candesartan content drinking water (1 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin II amount male 126 days 8 0.77 null 0.05 0.14 radioimmunoassay 0.0 unx 42 days blood ang II level 101279 2583
WKY blood glucose level unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 11 76.0 mg/dl 1.0 3.32 machine read blood glucose test strip 0.0 unx 168 days 99970 2378
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 17 312.0 mg/dl 24.0 98.95 machine read blood glucose test strip 0.0 unx 168 days 99972 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 16 3.19 ml/min/100g 0.13 0.52 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99994 2378
MW body weight unilateral nephrectomy (for 70 days) and captopril (500 mg/l) (for 70 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. body mass male 0 days 5 234.0 g 17.0 38.01 body measuring method 0.0 unx 70 days 101155 2581
MW systolic blood pressure unilateral nephrectomy (for 14 days) and captopril (500 mg/l) (for 14 days) then puromycin aminonucleoside (100 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 5 undefined 94.0 mmHg 3.0 6.71 tail cuff plethysmography 0.0 unx 14 days 101160 2581
MW blood urea nitrogen level unilateral nephrectomy (for 14 days) and captopril (500 mg/l) (for 14 days) then puromycin aminonucleoside (100 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. blood urea nitrogen amount male 0 days 5 26.0 mg/dl 1.0 2.24 blood urea nitrogen analysis 0.0 unx 14 days 101179 2581
MW blood urea nitrogen level unilateral nephrectomy (for 70 days) and captopril (500 mg/l) (for 70 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. blood urea nitrogen amount male 0 days 5 32.0 mg/dl 3.0 6.71 blood urea nitrogen analysis 0.0 unx 70 days 101188 2581
MW urine total protein excretion rate unilateral nephrectomy (for 70 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. total urine protein amount male 0 days 7 18.0 mg/d 4.0 10.58 Bradford protein assay 0.0 unx 70 days 101200 2581
MW glomerular filtration rate unilateral nephrectomy (for 70 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. glomerular filtration trait male 0 days 6 0.57 ml/min 0.07 0.17 inulin analysis by liquid phase colorimetry 0.0 unx 70 days 101204 2581
SHR/NCrlCrlj blood sodium level unilateral nephrectomy (for 42 days) then controlled candesartan content drinking water (1 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood sodium amount male 126 days 8 142.0 mmol/l 2.0 5.66 automated serum sodium test 0.0 unx 42 days 101239 2583
SD food intake rate unilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. eating behavior trait male 0 days 8 23.0 g/d 2.12 6.0 unspecified method 0.0 unx 28 days change from surgery weight 101612 2602
SD heart wet weight unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. heart mass male 0 days 8 1.33 g 0.05 0.13 post excision weight measurement 0.0 unx 28 days 101619 2602
SD urine total protein excretion rate unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. total urine protein amount male 0 days 8 283.0 mg/d 52.33 148.0 urine protein analysis 0.0 unx 28 days 101623 2602
SD plasma potassium level unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. blood potassium amount male 0 days 7 6.2 mmol/l 0.15 0.4 ex vivo blood analysis 0.0 unx 28 days 101597 2602
SD body weight unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. body mass male 0 days 5 285.0 g 6.71 15.0 body weighing method 0.0 unx 13 days 101537 2602
SD plasma aldosterone level unilateral nephrectomy (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. blood aldosterone amount male 0 days 11 526.0 pg/ml 78.39 260.0 plasma aldosterone analysis 0.0 unx 13 days - 101556 2602
SD plasma renin activity level unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. renin activity male 0 days 5 13.3 ng/ml/h 5.5 12.3 radioimmunoassay 0.0 unx 13 days 101565 2602
SD plasma renin activity level unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. renin activity male 0 days 5 5.2 ng/ml/h 2.24 5.0 radioimmunoassay 0.0 unx 13 days 101566 2602
SD body weight unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. body mass male 0 days 6 312.0 g 9.8 24.0 body weighing method 0.0 unx 28 days 101574 2602
SD left kidney wet weight unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney mass male 0 days 7 1.91 g 0.21 0.55 post excision weight measurement 0.0 unx 28 days remnant kidney 101580 2602
SD urine total protein excretion rate unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. total urine protein amount male 0 days 7 203.0 mg/d 38.93 103.0 urine protein analysis 0.0 unx 28 days 101592 2602
SHR/NCrlCrlj serum creatinine level unilateral nephrectomy (for 42 days) then controlled candesartan content drinking water (1 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood creatinine amount male 126 days 8 0.67 mg/dl 0.04 0.11 serum creatinine analysis 0.0 unx 42 days 101247 2583
SHR/NCrlCrlj serum creatinine level unilateral nephrectomy (for 42 days) then controlled delapril content drinking water (30 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood creatinine amount male 126 days 9 0.74 mg/dl 0.04 0.12 serum creatinine analysis 0.0 unx 42 days 101248 2583
SHR/NCrlCrlj blood urea nitrogen level unilateral nephrectomy (for 42 days) then controlled hydralazine content drinking water (15 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood urea nitrogen amount male 126 days 5 52.0 mg/dl 4.0 8.94 blood urea nitrogen analysis 0.0 unx 42 days 101253 2583
SHR/NCrlCrlj plasma renin activity level unilateral nephrectomy (for 42 days) then controlled candesartan content drinking water (1 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. renin activity male 126 days 8 9.8 ng/ml/h 1.7 4.81 radioimmunoassay 0.0 unx 42 days 101263 2583
SHR/NCrlCrlj plasma aldosterone level unilateral nephrectomy (for 42 days) then controlled delapril content drinking water (30 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood aldosterone amount male 126 days 9 369.0 pg/ml 54.0 162.0 plasma aldosterone analysis 0.0 unx 42 days 101268 2583
SHR/NCrlCrlj plasma angiotensin I level unilateral nephrectomy (for 42 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin I amount male 126 days 5 169.0 pg/ml 33.0 73.79 radioimmunoassay 0.0 unx 42 days 101270 2583
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 8 0.52 ml/min/100g 0.03 0.07 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99947 2378
ACI.FHH-(rs105487995-rs105373896)/Mcwi urine total protein excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. total urine protein amount male 91 days 8 62.94 mg/d 7.34 20.76 urine protein analysis 0.0 unx 56 days rf-1-1 100052 2400
ACI.FHH-(rgdv393055223-rs198922144)/Mcwi urine total protein excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. total urine protein amount male 91 days 7 173.13 mg/d 18.71 49.5 urine protein analysis 0.0 unx 56 days rf-1-4 100055 2400
ACI.FHH-(rs105373896-rgdv253272372)/Mcwi urine total protein excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. total urine protein amount male 91 days 6 41.34 mg/d 4.81 11.78 urine protein analysis 0.0 unx 56 days rf-1-6 100057 2400
ACI.FHH-(rs105487995-rs106411696)/Mcwi urine albumin excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. urine albumin amount male 91 days 8 33.72 mg/d 6.92 19.57 urine albumin analysis 0.0 unx 56 days rf-1-2 100061 2400
ACI.FHH-(rgdv393055223-rs198076037)/Mcwi urine albumin excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. urine albumin amount male 91 days 7 27.46 mg/d 3.8 10.05 urine albumin analysis 0.0 unx 56 days rf-1-5 100064 2400
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 8 8.8 mmHg/ml/min 0.5 1.41 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99962 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 6 8.8 mmHg/ml/min 0.5 1.22 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99964 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 8 41.62 ml/d 9.07 25.66 metabolic cage urine volume measurement method 0.0 unx 28 days 99968 2378
SBH/Ygl urine total protein excretion rate unilateral nephrectomy (for 150 days) Yagil Y, et al., Physiol Genomics. 2010 Nov 29;42A(4):301-16. Epub 2010 Sep 28. total urine protein amount female 170 days 7 202.0 mg/d 24.0 63.5 urine protein analysis 0.0 0 106689 3037
SHR/FubRkb plasma cystatin C level unilateral nephrectomy (for 126 days) Schulz A, etal., Physiol Genomics. 2012 Jan 18;44(1):110-6. Epub 2011 Nov 22. blood cystatin C amount male 168 days 15 0.07 mg/l 0.0 0.01 automated plasma protein analysis 0.0 0 109567 3148
SHR/FubRkb right kidney wet weight unilateral nephrectomy (for 126 days) Schulz A, etal., Physiol Genomics. 2012 Jan 18;44(1):110-6. Epub 2011 Nov 22. kidney mass male 168 days 15 1.63 g 0.05 0.19 post excision weight measurement kidney 0.0 0 109555 3148
SHR-Chr 8MWF/Rkb right kidney wet weight unilateral nephrectomy (for 126 days) Schulz A, etal., Physiol Genomics. 2012 Jan 18;44(1):110-6. Epub 2011 Nov 22. kidney mass male 168 days 15 1.59 g 0.04 0.15 post excision weight measurement kidney 0.0 0 109556 3148
WKY heart weight to body weight ratio unilateral nephrectomy (for 150 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. heart mass male 0 days 11 2.4 g/kg 0.1 0.33 post excision weight measurement 0.0 unx 150 days 107450 2378
WKY heart weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. heart mass male 0 days 17 3.2 g/kg 0.1 0.41 post excision weight measurement 0.0 unx 150 days 107452 2378
WKY body weight unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 16 261.0 g 7.0 28.0 body weighing method 0.0 unx 150 days 107448 2378
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 17 13.2 x 10E3 um2 3.3 13.61 ex vivo light microscopy with histochemistry 0.0 unx 150 days 107511 2378
WKY heart weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. heart mass male 0 days 16 3.1 g/kg 0.1 0.4 post excision weight measurement 0.0 unx 150 days 107454 2378
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 17 17.0 x 10E3 um2 4.1 16.9 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107462 2378
ACI.FHH-(D1Mit18-D1Mit8)(D14Mit11-D14Hmgc14b)(D14Rat65-D14Rat90)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. kidney glomerulus integrity trait not specified 168 days-175 days 12 30.0 % 3.0 10.39 ex vivo light microscopy 0.0 unilateral nephrectomy 126 days Original CMO_ID, CMO:0001176, was merged into current ID and field automatically updated. 4-26-2013 68876 832
ACI/Eur urine total protein excretion rate to body weight ratio unilateral nephrectomy Shiozawa M, et al., J Am Soc Nephrol 2000 Nov;11(11):2068-78. total urine protein amount male 91 days-98 days 21 5.9 mg/d/100 g 0.59 2.7 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 unilateral nephrectomy 39 days performed at 5 to 6 weeks of age urine TOTAL protein excretion rate to body weight ratio 69154 1128
ACI.FHH-(rs105487995-rs106411696)/Mcwi urine total protein excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. total urine protein amount male 91 days 8 81.88 mg/d 16.62 47.01 urine protein analysis 0.0 unx 56 days rf-1-2 100053 2400
WKY hematocrit unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. erythrocyte quantity male 0 days 16 45.8 % 0.5 2.0 hematocrit analysis 0.0 unx 168 days 99978 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 16 49.25 ml/d 5.18 20.74 metabolic cage urine volume measurement method 0.0 unx 168 days 100004 2378
MW systolic blood pressure unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 7 undefined 118.0 mmHg 2.0 5.29 tail cuff plethysmography 0.0 unx 42 days 101163 2581
MW mean arterial blood pressure unilateral nephrectomy (for 70 days) and captopril (500 mg/l) (for 70 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 5 undefined 87.0 mmHg 4.0 8.94 vascular indwelling catheter method 0.0 unx 70 days 101174 2581
SD systolic blood pressure unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. arterial blood pressure trait male 0 days 6 undefined 186.0 mmHg 10.61 26.0 tail cuff plethysmography 0.0 unx 28 days 101586 2602
SD systolic blood pressure unilateral nephrectomy (for 14 days) then spironolactone (5.56 mg/kg/d) (for 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. arterial blood pressure trait male 0 days 8 undefined 192.0 mmHg 7.07 20.0 tail cuff plethysmography 0.0 unx 14 days 101616 2602
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 7 2.16 ml/min/100g 0.18 0.48 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99950 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 8 0.26 null 0.01 0.04 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99956 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 6 0.21 null 0.01 0.03 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99959 2378
ACI/Eur body weight unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. body mass male 173 days-180 days 8 308.0 g 5.0 14.14 body weighing method 0.0 0 67678 751
FHH/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy Shiozawa M, et al., J Am Soc Nephrol 2000 Nov;11(11):2068-78. kidney glomerulus integrity trait male 91 days-98 days 26 52.1 % 2.29 11.7 ex vivo light microscopy 0.0 unilateral nephrectomy 39 days performed at 5 to 6 weeks of age 69159 1128
ACI/Eur plasma creatinine level unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. blood creatinine amount male 173 days-180 days 11 0.77 mg/dl 0.05 0.15 plasma creatinine analysis by Jaffe reaction without deproteinization with spectrophotometric readout 0.0 0 Jaffe method colorimetric spectrometry 68005 751
ACI.FHH-(D1Rat384-D1Rat156)/Eur body weight unilateral nephrectomy van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. body mass not specified 168 days-175 days 12 305.0 g 8.0 27.71 body weighing method 0.0 unilateral nephrectomy 126 days 67900 832
FHH/Eur body weight unilateral nephrectomy Shiozawa M, et al., J Am Soc Nephrol 2000 Nov;11(11):2068-78. body mass male 91 days-98 days 26 310.0 g 2.94 15.0 body weighing method 0.0 unilateral nephrectomy 39 days performed at 5 to 6 weeks of age 69140 1128
ACI/Eur systolic blood pressure unilateral nephrectomy Shiozawa M, et al., J Am Soc Nephrol 2000 Nov;11(11):2068-78. arterial blood pressure trait male 91 days-98 days 21 113.0 mmHg 1.96 9.0 tail cuff plethysmography 0.0 unilateral nephrectomy 39 days performed at 5 to 6 weeks of age 69141 1128
ACI.FHH-(D1Rat384-D1Rat156)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. kidney glomerulus integrity trait not specified 168 days-175 days 12 13.0 % 2.0 6.93 ex vivo light microscopy 0.0 unilateral nephrectomy 126 days Original CMO_ID, CMO:0001176, was merged into current ID and field automatically updated. 4-26-2013 68875 832
SD creatinine clearance controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. glomerular filtration trait female 0 days 13 0.3 ml/min 0.03 0.11 serum creatinine analysis 0.0 unx 97 days 100642 2499
SD creatinine clearance controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then enalapril (25 mg/l) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. glomerular filtration trait female 0 days 12 0.56 ml/min 0.03 0.1 serum creatinine analysis 0.0 unx 97 days 100643 2499
SD creatinine clearance controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. glomerular filtration trait female 0 days 10 0.35 ml/min 0.02 0.06 serum creatinine analysis 0.0 unx 97 days 100644 2499
SD serum parathyroid hormone level controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then enalapril (25 mg/l) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. blood parathyroid hormone amount female 0 days 12 371.0 pg/ml 100.0 346.41 serum parathyroid hormone analysis 0.0 unx 97 days 100648 2499
SD left kidney wet weight unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney mass male 0 days 5 1.49 g 0.1 0.23 post excision weight measurement 0.0 unx 13 days remnant kidney 101546 2602
SD urine total protein excretion rate unilateral nephrectomy (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. total urine protein amount male 0 days 11 121.0 mg/d 16.28 54.0 urine protein analysis 0.0 unx 13 days - 101552 2602
SD plasma aldosterone level unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. blood aldosterone amount male 0 days 5 487.0 pg/ml 50.98 114.0 plasma aldosterone analysis 0.0 unx 13 days 101558 2602
SD adrenal gland weight unilateral nephrectomy (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. adrenal gland mass male 0 days 11 63.0 mg 1.21 4.0 post excision weight measurement 0.0 unx 13 days - 101560 2602
SD adrenal gland weight unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. adrenal gland mass male 0 days 5 60.0 mg 3.13 7.0 post excision weight measurement 0.0 unx 13 days 101562 2602
SD change in body weight unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. body mass male 0 days 6 106.0 g 10.61 26.0 body weighing method 0.0 unx 28 days change from surgery weight 101578 2602
SD urine total protein excretion rate unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. total urine protein amount male 0 days 7 30.0 mg/d 5.67 15.0 urine protein analysis 0.0 unx 28 days 101593 2602
SD urine total protein excretion rate unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. total urine protein amount male 0 days 6 217.0 mg/d 28.99 71.0 urine protein analysis 0.0 unx 28 days 101594 2602
SD body weight unilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. body mass male 0 days 8 300.0 g 10.96 31.0 body weighing method 0.0 unx 28 days 101608 2602
MW body weight unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. body mass male 0 days 7 220.0 g 9.0 23.81 body measuring method 0.0 unx 14 days 101142 2581
MW body weight unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. body mass male 0 days 7 260.0 g 6.0 15.87 body measuring method 0.0 unx 42 days 101146 2581
MW systolic blood pressure unilateral nephrectomy (for 14 days) and captopril (500 mg/l) (for 42 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 5 undefined 95.0 mmHg 2.0 4.47 tail cuff plethysmography 0.0 unx 42 days 101164 2581
MW urine total protein excretion rate unilateral nephrectomy (for 42 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. total urine protein amount male 0 days 6 313.0 mg/d 40.0 97.98 Bradford protein assay 0.0 unx 42 days 101195 2581
MW glomerular filtration rate unilateral nephrectomy (for 70 days) and captopril (500 mg/l) (for 70 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. glomerular filtration trait male 0 days 5 0.94 ml/min 0.11 0.25 inulin analysis by liquid phase colorimetry 0.0 unx 70 days 101206 2581
SHR/NCrlCrlj blood sodium level unilateral nephrectomy (for 42 days) then vehicle control condition (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood sodium amount male 126 days 5 140.0 mmol/l 1.0 2.24 automated serum sodium test 0.0 unx 42 days 101238 2583
WKY hematocrit unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. erythrocyte quantity male 0 days 16 44.5 % 0.6 2.4 hematocrit analysis 0.0 unx 168 days 99979 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 11 0.23 null 0.01 0.03 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99985 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 17 0.21 null 0.01 0.05 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99987 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 17 3.3 ml/min/100g 0.11 0.45 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99992 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 17 41.47 ml/d 4.46 18.41 metabolic cage urine volume measurement method 0.0 unx 168 days 100002 2378
SD left kidney wet weight unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney mass male 0 days 8 1.96 g 0.16 0.44 post excision weight measurement 0.0 unx 28 days 101613 2602
SD systolic blood pressure unilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. arterial blood pressure trait male 0 days 8 undefined 190.0 mmHg 9.9 28.0 tail cuff plethysmography 0.0 unx 28 days 101618 2602
SD kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney glomerulus integrity trait male 0 days 8 31.0 % 5.66 16.0 ex vivo light microscopy with histochemistry 0.0 unx 28 days 101629 2602
SHR/NCrlCrlj blood potassium level unilateral nephrectomy (for 42 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood potassium amount male 126 days 5 5.7 mmol/l 0.4 0.89 automated serum potassium test 0.0 unx 42 days 101242 2583
SHR/NCrlCrlj blood potassium level unilateral nephrectomy (for 42 days) then controlled hydralazine content drinking water (15 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood potassium amount male 126 days 5 4.6 mmol/l 0.2 0.45 automated serum potassium test 0.0 unx 42 days 101245 2583
SHR/NCrlCrlj serum creatinine level unilateral nephrectomy (for 42 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood creatinine amount male 126 days 5 0.95 mg/dl 0.08 0.18 serum creatinine analysis 0.0 unx 42 days 101246 2583
SHR/NCrlCrlj serum creatinine level unilateral nephrectomy (for 42 days) then controlled hydralazine content drinking water (15 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood creatinine amount male 126 days 5 0.92 mg/dl 0.06 0.13 serum creatinine analysis 0.0 unx 42 days 101249 2583
SHR/NCrlCrlj blood urea nitrogen level unilateral nephrectomy (for 42 days) then controlled delapril content drinking water (30 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood urea nitrogen amount male 126 days 9 40.0 mg/dl 2.0 6.0 blood urea nitrogen analysis 0.0 unx 42 days 101252 2583
SHR/NCrlCrlj creatinine clearance to body weight ratio unilateral nephrectomy (for 14 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. glomerular filtration trait male 98 days 15 0.36 ml/min/100g 0.04 0.16 blood creatinine analysis 0.0 unx 14 days 101254 2583
WKY body weight unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 8 215.0 g 10.0 28.28 body weighing method 0.0 unx 28 days 99936 2378
WKY blood glucose level unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 7 74.0 mg/dl 2.0 5.29 machine read blood glucose test strip 0.0 unx 28 days 99940 2378
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 7 0.49 ml/min/100g 0.03 0.08 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99945 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 8 2.32 ml/min/100g 0.11 0.31 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99953 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 7 0.23 null 0.01 0.03 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99955 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 7 10.0 mmHg/ml/min 0.6 1.59 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99960 2378
ACI/EurMcwi urine total protein excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. total urine protein amount male 91 days 9 68.52 mg/d 7.28 21.84 urine protein analysis 0.0 unx 56 days rf-1-1 100051 2400
ACI.FHH-(rgdv393055223-rs107095981)/Mcwi urine albumin excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. urine albumin amount male 91 days 5 93.07 mg/d 13.96 31.22 urine albumin analysis 0.0 unx 56 days rf-1-3 100062 2400
ACI.FHH-(rs198076037-rs105278863)/Mcwi urine albumin excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. urine albumin amount male 91 days 5 69.44 mg/d 7.49 16.75 urine albumin analysis 0.0 unx 56 days rf-1-7 100066 2400
SBN/Ygl urine total protein excretion rate unilateral nephrectomy (for 120 days) Yagil Y, et al., Physiol Genomics. 2010 Nov 29;42A(4):301-16. Epub 2010 Sep 28. total urine protein amount male 140 days 6 78.0 mg/d 12.0 29.39 urine protein analysis 0.0 0 106687 3037
WKY body weight unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 16 267.0 g 9.0 36.0 body weighing method 0.0 unx 150 days 107449 2378
WKY left kidney wet weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney mass male 0 days 16 8.1 mg/g 0.2 0.8 post excision weight measurement 0.0 unx 150 days 107458 2378
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 16 16.4 x 10E3 um2 4.1 16.4 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107464 2378
ACI.FHH-(D1Rat384-D1Rat452)(D17Rat61-D1Arb5)(D17Rat51)/Eur body weight unilateral nephrectomy then NG-nitroarginine methyl ester (10-21 ml/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. body mass not specified 168 days-175 days 9 277.0 g 6.0 18.0 body weighing method 0.0 unilateral nephrectomy 126 days 67910 832
FHH/Eur systolic blood pressure unilateral nephrectomy Shiozawa M, et al., J Am Soc Nephrol 2000 Nov;11(11):2068-78. arterial blood pressure trait male 91 days-98 days 26 151.0 mmHg 1.96 10.0 tail cuff plethysmography 0.0 unilateral nephrectomy 39 days performed at 5 to 6 weeks of age 69142 1128
ACI/Eur body weight unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. body mass male 173 days-180 days 11 292.0 g 9.0 29.85 body weighing method 0.0 0 67681 751
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 8 0.79 ml/min/100g 0.03 0.08 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99946 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 8 9.2 mmHg/ml/min 0.4 1.13 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99963 2378
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 17 0.69 ml/min/100g 0.03 0.13 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99982 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 16 0.22 null 0.01 0.04 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99988 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 16 3.15 ml/min/100g 0.13 0.52 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99993 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 17 39.46 ml/d 4.61 19.0 metabolic cage urine volume measurement method 0.0 unx 168 days 100001 2378
MW systolic blood pressure unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 7 undefined 118.0 mmHg 2.0 5.29 tail cuff plethysmography 0.0 unx 14 days 101159 2581
MW blood urea nitrogen level unilateral nephrectomy (for 70 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. blood urea nitrogen amount male 0 days 7 26.0 mg/dl 1.0 2.65 blood urea nitrogen analysis 0.0 unx 70 days 101187 2581
MW urine total protein excretion rate unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. total urine protein amount male 0 days 7 23.0 mg/d 2.0 5.29 Bradford protein assay 0.0 unx 42 days 101196 2581
SD urine total protein excretion rate unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. total urine protein amount male 0 days 5 87.0 mg/d 12.52 28.0 urine protein analysis 0.0 unx 13 days 101554 2602
SD body weight unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. body mass male 0 days 7 309.0 g 18.9 50.0 body weighing method 0.0 unx 28 days 101572 2602
SD left kidney wet weight unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney mass male 0 days 7 1.47 g 0.07 0.18 post excision weight measurement 0.0 unx 28 days remnant kidney 101581 2602
SD body weight unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. body mass male 0 days 8 315.0 g 9.55 27.0 body weighing method 0.0 unx 28 days 101607 2602
SD food intake rate unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. eating behavior trait male 0 days 8 19.0 g/d 2.83 8.0 unspecified method 0.0 unx 28 days 101611 2602
SD kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney glomerulus integrity trait male 0 days 7 4.7 % 1.97 5.2 ex vivo light microscopy with histochemistry 0.0 unx 28 days 101605 2602
ACI.FHH-(D1Rat324-D1Rat156)/Eur plasma albumin level unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. blood albumin amount male 173 days-180 days 8 27.3 g/l 0.9 2.55 bromocresol green-based urine albumin analysis with spectrophotometric readout 0.0 0 bromocresol green 68028 751
ACI/Eur urine albumin excretion rate to body weight ratio unilateral nephrectomy Shiozawa M, et al., J Am Soc Nephrol 2000 Nov;11(11):2068-78. urine albumin amount male 91 days-98 days 21 3.2 mg/d/100 g 0.5 2.3 bromocresol green-based urine albumin analysis with spectrophotometric readout 0.0 unilateral nephrectomy 39 days performed at 5 to 6 weeks of age 69156 1128
ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur plasma creatinine level unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. blood creatinine amount male 173 days-180 days 10 0.58 mg/dl 0.02 0.07 plasma creatinine analysis by Jaffe reaction without deproteinization with spectrophotometric readout 0.0 0 Jaffe method colorimetric spectrometry 68003 751
ACI/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. kidney glomerulus integrity trait not specified 168 days-175 days 12 15.0 % 3.0 10.39 ex vivo light microscopy 0.0 unilateral nephrectomy 126 days Original CMO_ID, CMO:0001176, was merged into current ID and field automatically updated. 4-26-2013 68874 832
ACI.FHH-(D1Rat384-D1Rat452)(D17Rat61-D1Arb5)(D17Rat51)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. kidney glomerulus integrity trait not specified 168 days-175 days 12 12.0 % 2.0 6.93 ex vivo light microscopy 0.0 unilateral nephrectomy 126 days Original CMO_ID, CMO:0001176, was merged into current ID and field automatically updated. 4-26-2013 68877 832
SD body weight controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. body mass female 0 days 10 291.9 g 6.4 20.24 body weighing method 0.0 unx 97 days 100634 2499
SD body weight controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days) and enalapril (25 mg/l) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. body mass female 0 days 12 290.6 g 6.8 23.56 body weighing method 0.0 unx 97 days 100635 2499
SD serum creatinine level controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. blood creatinine amount female 0 days 10 1.5 mg/dl 0.11 0.35 serum creatinine analysis 0.0 unx 97 days 100639 2499
SD serum parathyroid hormone level controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. blood parathyroid hormone amount female 0 days 10 629.0 pg/ml 208.0 657.75 serum parathyroid hormone analysis 0.0 unx 97 days 100649 2499
SHR/NCrlCrlj blood sodium level unilateral nephrectomy (for 42 days) then controlled hydralazine content drinking water (15 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood sodium amount male 126 days 5 141.0 mmol/l 2.0 4.47 automated serum sodium test 0.0 unx 42 days 101241 2583
SHR/NCrlCrlj blood potassium level unilateral nephrectomy (for 42 days) then controlled candesartan content drinking water (1 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood potassium amount male 126 days 8 5.9 mmol/l 0.2 0.57 automated serum potassium test 0.0 unx 42 days 101243 2583
SHR/NCrlCrlj creatinine clearance to body weight ratio unilateral nephrectomy (for 14 days) then controlled delapril content drinking water (30 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. glomerular filtration trait male 98 days 9 0.34 ml/min/100g 0.03 0.08 blood creatinine analysis 0.0 unx 14 days 101256 2583
SHR/NCrlCrlj creatinine clearance to body weight ratio unilateral nephrectomy (for 42 days) then controlled hydralazine content drinking water (15 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. glomerular filtration trait male 126 days 5 0.23 ml/min/100g 0.04 0.08 blood creatinine analysis 0.0 unx 42 days 101261 2583
SHR/NCrlCrlj plasma renin activity level unilateral nephrectomy (for 42 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. renin activity male 126 days 5 1.3 ng/ml/h 0.2 0.45 radioimmunoassay 0.0 unx 42 days 101262 2583
SHR/NCrlCrlj plasma renin activity level unilateral nephrectomy (for 42 days) then controlled delapril content drinking water (30 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. renin activity male 126 days 9 5.1 ng/ml/h 0.5 1.5 radioimmunoassay 0.0 unx 42 days 101264 2583
SHR/NCrlCrlj plasma renin activity level unilateral nephrectomy (for 42 days) then controlled hydralazine content drinking water (15 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. renin activity male 126 days 5 5.5 ng/ml/h 1.7 3.8 radioimmunoassay 0.0 unx 42 days 101265 2583
SHR/NCrlCrlj plasma aldosterone level unilateral nephrectomy (for 42 days) then controlled hydralazine content drinking water (15 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood aldosterone amount male 126 days 5 581.0 pg/ml 92.0 205.72 plasma aldosterone analysis 0.0 unx 42 days 101269 2583
SHR/NCrlCrlj plasma angiotensin I level unilateral nephrectomy (for 42 days) then controlled candesartan content drinking water (1 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin I amount male 126 days 8 338.0 pg/ml 28.0 79.2 radioimmunoassay 0.0 unx 42 days 101271 2583
SHR/NCrlCrlj plasma angiotensin II level to plasma angiotensin I level ratio unilateral nephrectomy (for 42 days) then controlled delapril content drinking water (30 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin II amount male 126 days 9 0.34 null 0.04 0.12 radioimmunoassay 0.0 unx 42 days blood ang II level 101280 2583
SHR/NCrlCrlj plasma angiotensin II level to plasma angiotensin I level ratio unilateral nephrectomy (for 42 days) then controlled hydralazine content drinking water (15 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin II amount male 126 days 5 0.59 null 0.04 0.09 radioimmunoassay 0.0 unx 42 days blood ang II level 101281 2583
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 16 0.66 ml/min/100g 0.02 0.09 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99983 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 11 2.28 ml/min/100g 0.07 0.23 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99990 2378
SD change in body weight unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. body mass male 0 days 5 74.0 g 7.6 17.0 body weighing method 0.0 unx 13 days change from surgery weight 101541 2602
SD left kidney wet weight unilateral nephrectomy (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney mass male 0 days 11 1.37 g 0.07 0.23 post excision weight measurement 0.0 unx 13 days remnant kidney 101544 2602
SD systolic blood pressure unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. arterial blood pressure trait male 0 days 5 undefined 149.0 mmHg 9.39 21.0 tail cuff plethysmography 0.0 unx 13 days 101550 2602
SD urine total protein excretion rate unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. total urine protein amount male 0 days 5 31.0 mg/d 5.37 12.0 urine protein analysis 0.0 unx 13 days 101553 2602
SD systolic blood pressure unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. arterial blood pressure trait male 0 days 7 undefined 109.0 mmHg 4.16 11.0 tail cuff plethysmography 0.0 unx 28 days 101585 2602
SD heart wet weight unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. heart mass male 0 days 7 1.33 g 0.07 0.19 post excision weight measurement 0.0 unx 28 days 101588 2602
SD change in body weight unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. body mass male 0 days 8 59.0 g 10.96 31.0 body weighing method 0.0 unx 28 days change from surgery weight 101609 2602
SD urine total protein excretion rate unilateral nephrectomy (for 14 days) then spironolactone (5.56 mg/kg/d) (for 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. total urine protein amount male 0 days 8 130.0 mg/d 19.09 54.0 urine protein analysis 0.0 unx 14 days 101622 2602
SD plasma potassium level unilateral nephrectomy (for 14 days) then spironolactone (5.56 mg/kg/d) (for 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. blood potassium amount male 0 days 8 5.2 mmol/l 0.14 0.4 ex vivo blood analysis 0.0 unx 14 days 101626 2602
SD adrenal gland weight unilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. adrenal gland mass male 0 days 8 73.0 mg 2.83 8.0 post excision weight measurement 0.0 unx 28 days 101628 2602
MW body weight unilateral nephrectomy (for 70 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. body mass male 0 days 6 213.0 g 17.0 41.64 body measuring method 0.0 unx 70 days 101153 2581
MW systolic blood pressure unilateral nephrectomy (for 42 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 6 undefined 125.0 mmHg 4.0 9.8 tail cuff plethysmography 0.0 unx 42 days 101162 2581
MW systolic blood pressure unilateral nephrectomy (for 70 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 7 undefined 122.0 mmHg 2.0 5.29 tail cuff plethysmography 0.0 unx 70 days 101168 2581
MW mean arterial blood pressure unilateral nephrectomy (for 70 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 7 undefined 108.0 mmHg 2.0 5.29 vascular indwelling catheter method 0.0 unx 70 days 101173 2581
MW blood urea nitrogen level unilateral nephrectomy (for 14 days) then puromycin aminonucleoside (100 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. blood urea nitrogen amount male 0 days 6 26.0 mg/dl 2.0 4.9 blood urea nitrogen analysis 0.0 unx 14 days 101177 2581
MW blood urea nitrogen level unilateral nephrectomy (for 42 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. blood urea nitrogen amount male 0 days 6 29.0 mg/dl 2.0 4.9 blood urea nitrogen analysis 0.0 unx 42 days 101181 2581
SHR/NCrlCrlj plasma angiotensin II level unilateral nephrectomy (for 42 days) then controlled candesartan content drinking water (1 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin II amount male 126 days 8 26.6 pg/ml 3.6 10.18 radioimmunoassay 0.0 unx 42 days blood ang II level 101275 2583
SHR/NCrlCrlj plasma angiotensin II level unilateral nephrectomy (for 42 days) then controlled delapril content drinking water (30 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin II amount male 126 days 9 9.3 pg/ml 1.4 4.2 radioimmunoassay 0.0 unx 42 days blood ang II level 101276 2583
SHR/NCrlCrlj plasma angiotensin II level unilateral nephrectomy (for 42 days) then controlled hydralazine content drinking water (15 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin II amount male 126 days 5 16.0 pg/ml 3.0 6.71 radioimmunoassay 0.0 unx 42 days blood ang II level 101277 2583
ACI.FHH-(rgdv393055223-rs198076037)/Mcwi urine total protein excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. total urine protein amount male 91 days 7 67.24 mg/d 4.02 10.64 urine protein analysis 0.0 unx 56 days rf-1-5 100056 2400
ACI.FHH-(rs105373896-rgdv253272372)/Mcwi urine albumin excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. urine albumin amount male 91 days 6 16.35 mg/d 3.01 7.37 urine albumin analysis 0.0 unx 56 days rf-1-6 100065 2400
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 6 367.0 mg/dl 12.0 29.39 machine read blood glucose test strip 0.0 unx 28 days 99944 2378
WKY body weight unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 17 256.0 g 5.0 20.62 body weighing method 0.0 unx 150 days 107446 2378
WKY heart weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. heart mass male 0 days 17 3.5 g/kg 0.1 0.41 post excision weight measurement 0.0 unx 150 days 107451 2378
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 17 19.3 x 10E3 um2 4.8 19.79 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107461 2378
SHR-Chr 8MWF/Rkb urine albumin excretion rate unilateral nephrectomy (for 126 days) Schulz A, etal., Physiol Genomics. 2012 Jan 18;44(1):110-6. Epub 2011 Nov 22. urine albumin amount male 168 days 15 37.2 mg/d 4.9 18.98 enzyme linked immunosorbent assay 0.0 0 109565 3148
SHR-Chr 8MWF/Rkb plasma cystatin C level unilateral nephrectomy (for 126 days) Schulz A, etal., Physiol Genomics. 2012 Jan 18;44(1):110-6. Epub 2011 Nov 22. blood cystatin C amount male 168 days 15 0.07 mg/l 0.0 0.01 automated plasma protein analysis 0.0 0 109569 3148
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 16 11.7 x 10E3 um2 2.9 11.6 ex vivo light microscopy with histochemistry 0.0 unx 150 days 107514 2378
ACI.FHH-(D1Rat384-D1Rat156)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then NG-nitroarginine methyl ester (10-21 mg/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. kidney glomerulus integrity trait not specified 168 days-175 days 11 42.0 % 6.0 19.9 ex vivo light microscopy 0.0 unilateral nephrectomy 126 days Original CMO_ID, CMO:0001176, was merged into current ID and field automatically updated. 4-26-2013 68883 832
FHH/Eur urine albumin excretion rate to body weight ratio unilateral nephrectomy Shiozawa M, et al., J Am Soc Nephrol 2000 Nov;11(11):2068-78. urine albumin amount male 91 days-98 days 26 57.6 mg/d/100 g 3.49 17.8 bromocresol green-based urine albumin analysis with spectrophotometric readout 0.0 unilateral nephrectomy 39 days performed at 5 to 6 weeks of age 69157 1128
SD body weight unilateral nephrectomy (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. body mass male 0 days 11 277.0 g 8.14 27.0 body weighing method 0.0 unx 13 days 101536 2602
SD change in body weight unilateral nephrectomy (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. body mass male 0 days 11 66.0 g 7.84 26.0 body weighing method 0.0 unx 13 days change from surgery weight 101540 2602
SD heart wet weight unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. heart mass male 0 days 7 0.88 g 0.04 0.11 post excision weight measurement 0.0 unx 28 days 101589 2602
SD plasma potassium level unilateral nephrectomy (for 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. blood potassium amount male 0 days 8 5.3 mmol/l 0.14 0.4 ex vivo blood analysis 0.0 unx 14 days 101625 2602
SD plasma potassium level unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. blood potassium amount male 0 days 6 4.5 mmol/l 0.2 0.5 ex vivo blood analysis 0.0 unx 28 days 101598 2602
SD serum creatinine level controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then enalapril (25 mg/l) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. blood creatinine amount female 0 days 12 0.93 mg/dl 0.02 0.07 serum creatinine analysis 0.0 unx 97 days 100638 2499
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 17 324.0 mg/dl 13.0 53.6 machine read blood glucose test strip 0.0 unx 168 days 99971 2378
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 16 308.0 mg/dl 15.0 60.0 machine read blood glucose test strip 0.0 unx 168 days 99973 2378
WKY hematocrit unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. erythrocyte quantity male 0 days 11 45.2 % 1.4 4.64 hematocrit analysis 0.0 unx 168 days 99975 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 17 0.29 null 0.01 0.05 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99986 2378
MW body weight unilateral nephrectomy (for 42 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. body mass male 0 days 6 237.0 g 12.0 29.39 body measuring method 0.0 unx 42 days 101145 2581
MW systolic blood pressure unilateral nephrectomy (for 70 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 6 undefined 122.0 mmHg 3.0 7.35 tail cuff plethysmography 0.0 unx 70 days 101167 2581
MW urine total protein excretion rate unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. total urine protein amount male 0 days 7 11.0 mg/d 2.0 5.29 Bradford protein assay 0.0 unx 14 days 101192 2581
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 8 2.33 ml/min/100g 0.09 0.25 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99952 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 8 38.02 ml/d 5.33 15.07 metabolic cage urine volume measurement method 0.0 unx 28 days 99967 2378
ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur body weight unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. body mass male 173 days-180 days 10 301.0 g 4.0 12.65 body weighing method 0.0 0 67679 751
ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur body weight unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. body mass male 173 days-180 days 9 284.0 g 6.0 18.0 body weighing method 0.0 0 67682 751
ACI/Eur plasma albumin level unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. blood albumin amount male 173 days-180 days 11 27.9 g/l 0.3 0.99 bromocresol green-based urine albumin analysis with spectrophotometric readout 0.0 0 bromocresol green 68029 751
ACI.FHH-(D1Rat324-D1Rat156)/Eur plasma albumin level unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. blood albumin amount male 173 days-180 days 8 24.0 g/l 1.0 2.83 bromocresol green-based urine albumin analysis with spectrophotometric readout 0.0 0 bromocresol green % glomerulosclerosis 68031 751
FHH/Eur urine total protein excretion rate to body weight ratio unilateral nephrectomy Shiozawa M, et al., J Am Soc Nephrol 2000 Nov;11(11):2068-78. total urine protein amount male 91 days-98 days 26 77.2 mg/d/100 g 4.0 20.4 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 unilateral nephrectomy 39 days performed at 5 to 6 weeks of age urine TOTAL protein excretion rate to body weight ratio 69155 1128
ACI/Eur body weight unilateral nephrectomy then NG-nitroarginine methyl ester (10-21 ml/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. body mass not specified 168 days-175 days 12 314.0 g 5.0 17.32 body weighing method 0.0 unilateral nephrectomy 126 days 67907 832
ACI/Eur plasma creatinine level unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. blood creatinine amount male 173 days-180 days 8 0.61 mg/dl 0.02 0.06 plasma creatinine analysis by Jaffe reaction without deproteinization with spectrophotometric readout 0.0 0 Jaffe method colorimetric spectrometry 68002 751
ACI.FHH-(D1Rat324-D1Rat156)/Eur plasma creatinine level unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. blood creatinine amount male 173 days-180 days 8 0.59 mg/dl 0.01 0.03 plasma creatinine analysis by Jaffe reaction without deproteinization with spectrophotometric readout 0.0 0 Jaffe method colorimetric spectrometry 68004 751
ACI.FHH-(D1Mit18-D1Mit8)(D14Mit11-D14Hmgc14b)(D14Rat65-D14Rat90)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then NG-nitroarginine methyl ester (10-21 mg/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. kidney glomerulus integrity trait not specified 168 days-175 days 2 59.0 % 11.0 15.56 ex vivo light microscopy 0.0 unilateral nephrectomy 126 days Original CMO_ID, CMO:0001176, was merged into current ID and field automatically updated. 4-26-2013 68884 832
ACI/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then NG-nitroarginine methyl ester (10-21 mg/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. kidney glomerulus integrity trait not specified 168 days-175 days 12 20.0 % 3.0 10.39 ex vivo light microscopy 0.0 unilateral nephrectomy 126 days Original CMO_ID, CMO:0001176, was merged into current ID and field automatically updated. 4-26-2013 68882 832
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 16 317.0 mg/dl 19.0 76.0 machine read blood glucose test strip 0.0 unx 168 days 99974 2378
WKY hematocrit unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. erythrocyte quantity male 0 days 17 44.8 % 0.6 2.47 hematocrit analysis 0.0 unx 168 days 99976 2378
WKY hematocrit unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. erythrocyte quantity male 0 days 17 45.6 % 0.3 1.24 hematocrit analysis 0.0 unx 168 days 99977 2378
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 17 0.5 ml/min/100g 0.03 0.12 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99981 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 16 0.21 null 0.01 0.03 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99989 2378
SD adrenal gland weight unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. adrenal gland mass male 0 days 8 71.0 mg 1.41 4.0 post excision weight measurement 0.0 unx 28 days 101627 2602
SD plasma potassium level unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. blood potassium amount male 0 days 7 5.0 mmol/l 0.15 0.4 ex vivo blood analysis 0.0 unx 28 days 101596 2602
SD adrenal gland weight unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. adrenal gland mass male 0 days 7 57.0 mg 1.51 4.0 post excision weight measurement 0.0 unx 28 days 101601 2602
SD kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney glomerulus integrity trait male 0 days 7 37.2 % 10.02 26.5 ex vivo light microscopy with histochemistry 0.0 unx 28 days 101604 2602
SD systolic blood pressure unilateral nephrectomy (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. arterial blood pressure trait male 0 days 11 undefined 185.0 mmHg 7.84 26.0 tail cuff plethysmography 0.0 unx 13 days - 101548 2602
SD plasma aldosterone level unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. blood aldosterone amount male 0 days 5 181.0 pg/ml 55.45 124.0 plasma aldosterone analysis 0.0 unx 13 days 101557 2602
SD adrenal gland weight unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. adrenal gland mass male 0 days 5 56.0 mg 1.79 4.0 post excision weight measurement 0.0 unx 13 days 101561 2602
SD body weight unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. body mass male 0 days 7 307.0 g 36.66 25.0 body weighing method 0.0 unx 28 days 101573 2602
SD change in body weight unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. body mass male 0 days 7 96.0 g 15.12 40.0 body weighing method 0.0 unx 28 days change from surgery weight 101576 2602
SD left kidney wet weight unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney mass male 0 days 6 2.03 g 0.2 0.48 post excision weight measurement 0.0 unx 28 days remnant kidney 101582 2602
SD systolic blood pressure unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. arterial blood pressure trait male 0 days 7 undefined 212.0 mmHg 7.56 20.0 tail cuff plethysmography 0.0 unx 28 days 101584 2602
SD heart wet weight unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. heart mass male 0 days 6 1.28 g 0.05 0.12 post excision weight measurement 0.0 unx 28 days 101590 2602
MW body weight unilateral nephrectomy (for 14 days) then puromycin aminonucleoside (100 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. body mass male 0 days 6 224.0 g 9.0 22.05 body measuring method 0.0 unx 14 days 101141 2581
MW systolic blood pressure unilateral nephrectomy (for 14 days) then puromycin aminonucleoside (100 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 6 undefined 122.0 mmHg 4.0 9.8 tail cuff plethysmography 0.0 unx 14 days 101158 2581
MW blood urea nitrogen level unilateral nephrectomy (for 14 days) and captopril (500 mg/l) (for 42 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. blood urea nitrogen amount male 0 days 5 31.0 mg/dl 1.0 2.24 blood urea nitrogen analysis 0.0 unx 42 days 101183 2581
MW urine total protein excretion rate unilateral nephrectomy (for 14 days) and captopril (500 mg/l) (for 42 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. total urine protein amount male 0 days 5 320.0 mg/d 146.0 326.47 Bradford protein assay 0.0 unx 42 days 101197 2581
MW urine total protein excretion rate unilateral nephrectomy (for 70 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. total urine protein amount male 0 days 6 348.0 mg/d 84.0 205.76 Bradford protein assay 0.0 unx 70 days 101199 2581
SHR/NCrlCrlj blood potassium level unilateral nephrectomy (for 42 days) then controlled delapril content drinking water (30 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood potassium amount male 126 days 9 5.1 mmol/l 0.3 0.9 automated serum potassium test 0.0 unx 42 days 101244 2583
SHR/NCrlCrlj blood urea nitrogen level unilateral nephrectomy (for 42 days) then controlled candesartan content drinking water (1 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood urea nitrogen amount male 126 days 8 54.0 mg/dl 5.0 14.14 blood urea nitrogen analysis 0.0 unx 42 days 101251 2583
SHR/NCrlCrlj creatinine clearance to body weight ratio unilateral nephrectomy (for 14 days) then controlled candesartan content drinking water (1 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. glomerular filtration trait male 98 days 10 0.36 ml/min/100g 0.03 0.1 blood creatinine analysis 0.0 unx 14 days 101255 2583
SHR/NCrlCrlj plasma aldosterone level unilateral nephrectomy (for 42 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood aldosterone amount male 126 days 5 389.0 pg/ml 86.0 192.3 plasma aldosterone analysis 0.0 unx 42 days 101266 2583
SHR/NCrlCrlj plasma angiotensin I level unilateral nephrectomy (for 42 days) then controlled delapril content drinking water (30 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin I amount male 126 days 9 279.0 pg/ml 21.0 63.0 radioimmunoassay 0.0 unx 42 days 101272 2583
SHR/NCrlCrlj plasma angiotensin I level unilateral nephrectomy (for 42 days) then controlled hydralazine content drinking water (15 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin I amount male 126 days 5 281.0 pg/ml 41.0 91.68 radioimmunoassay 0.0 unx 42 days 101273 2583
WKY body weight unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 8 233.0 g 5.0 14.14 body weighing method 0.0 unx 28 days 99938 2378
WKY body weight unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 6 229.0 g 6.0 14.7 body weighing method 0.0 unx 28 days 99939 2378
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 8 350.0 mg/dl 18.0 50.91 machine read blood glucose test strip 0.0 unx 28 days 99941 2378
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 8 357.0 mg/dl 11.0 31.11 machine read blood glucose test strip 0.0 unx 28 days 99943 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 8 0.23 null 0.12 0.34 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99957 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 8 0.23 null 0.14 0.4 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99958 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 8 23.47 ml/d 1.73 4.89 metabolic cage urine volume measurement method 0.0 unx 28 days 99966 2378
ACI.FHH-(rgdv393055223-rs107095981)/Mcwi urine total protein excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. total urine protein amount male 91 days 5 188.71 mg/d 20.03 44.79 urine protein analysis 0.0 unx 56 days rf-1-3 100054 2400
ACI.FHH-(rs105487995-rs105373896)/Mcwi urine albumin excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. urine albumin amount male 91 days 8 18.95 mg/d 2.93 8.29 urine albumin analysis 0.0 unx 56 days rf-1-1 100060 2400
SBN/Ygl urine total protein excretion rate unilateral nephrectomy (for 150 days) Yagil Y, et al., Physiol Genomics. 2010 Nov 29;42A(4):301-16. Epub 2010 Sep 28. total urine protein amount female 170 days 7 7.0 mg/d 3.0 7.94 urine protein analysis 0.0 0 106691 3037
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 16 11.1 x 10E3 um2 2.8 11.2 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107513 2378
SHR/FubRkb body weight unilateral nephrectomy (for 126 days) Schulz A, etal., Physiol Genomics. 2012 Jan 18;44(1):110-6. Epub 2011 Nov 22. body mass male 168 days 15 330.4 g 6.0 23.24 body weighing method 0.0 0 109550 3148
SHR/FubRkb right kidney wet weight to body weight ratio unilateral nephrectomy (for 126 days) Schulz A, etal., Physiol Genomics. 2012 Jan 18;44(1):110-6. Epub 2011 Nov 22. kidney mass male 168 days 15 5.02 mg/g 0.16 0.62 post excision weight measurement kidney 0.0 0 109559 3148
SHR-Chr 8MWF/Rkb right kidney wet weight to body weight ratio unilateral nephrectomy (for 126 days) Schulz A, etal., Physiol Genomics. 2012 Jan 18;44(1):110-6. Epub 2011 Nov 22. kidney mass male 168 days 15 4.71 mg/g 0.09 0.35 post excision weight measurement kidney 0.0 0 109560 3148
WKY body weight unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 17 274.0 g 6.0 24.74 body weighing method 0.0 unx 150 days 107447 2378
WKY left kidney wet weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney mass male 0 days 17 8.2 mg/g 0.2 0.82 post excision weight measurement 0.0 unx 150 days 107457 2378
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 11 8.7 x 10E3 um2 2.6 8.62 ex vivo light microscopy with histochemistry 0.0 unx 150 days 107510 2378
WKY left kidney wet weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) and bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney mass male 0 days 16 8.3 mg/g 0.2 0.8 post excision weight measurement 0.0 unx 150 days 107459 2378
WKY left kidney wet weight to body weight ratio unilateral nephrectomy (for 150 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney mass male 0 days 11 3.9 mg/g 0.1 0.33 post excision weight measurement 0.0 unx 150 days 107455 2378
ACI/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 173 days-180 days 11 13.0 % 2.0 6.63 ex vivo light microscopy with histochemistry 0.0 0 67959 751
SD change in body weight unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. body mass male 0 days 7 97.0 g 7.56 20.0 body weighing method 0.0 unx 28 days change from surgery weight 101577 2602
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 16 0.67 ml/min/100g 0.02 0.08 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99984 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 17 6.6 mmHg/ml/min 0.3 1.24 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99997 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) and bosentan (100 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 16 6.8 mmHg/ml/min 0.3 1.2 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99999 2378
MW body weight unilateral nephrectomy (for 14 days) and captopril (500 mg/l) (for 14 days) then puromycin aminonucleoside (100 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. body mass male 0 days 5 232.0 g 6.0 13.42 body measuring method 0.0 unx 14 days 101143 2581
MW body weight unilateral nephrectomy (for 14 days) and captopril (500 mg/l) (for 42 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. body mass male 0 days 5 207.0 g 17.0 38.01 body measuring method 0.0 unx 42 days 101147 2581
MW systolic blood pressure unilateral nephrectomy (for 70 days) and captopril (500 mg/l) (for 70 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 5 undefined 100.0 mmHg 4.0 8.94 tail cuff plethysmography 0.0 unx 70 days 101169 2581
MW mean arterial blood pressure unilateral nephrectomy (for 70 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 6 undefined 105.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 unx 70 days 101172 2581
MW urine total protein excretion rate unilateral nephrectomy (for 70 days) and captopril (500 mg/l) (for 70 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. total urine protein amount male 0 days 5 271.0 mg/d 131.0 292.92 Bradford protein assay 0.0 unx 70 days 101201 2581
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 8 0.54 ml/min/100g 0.02 0.05 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99948 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 8 9.0 mmHg/ml/min 0.4 1.13 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99961 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 6 44.93 ml/d 8.78 21.52 metabolic cage urine volume measurement method 0.0 unx 28 days 99969 2378
ACI.FHH-(D1Rat324-D1Rat156)/Eur body weight unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. body mass male 173 days-180 days 8 235.0 g 9.0 25.46 body weighing method 0.0 0 67683 751
ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur plasma creatinine level unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. blood creatinine amount male 173 days-180 days 9 0.74 mg/dl 0.02 0.07 plasma creatinine analysis by Jaffe reaction without deproteinization with spectrophotometric readout 0.0 0 Jaffe method colorimetric spectrometry 68006 751
ACI.FHH-(D1Rat324-D1Rat156)/Eur plasma creatinine level unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. blood creatinine amount male 173 days-180 days 8 1.33 mg/dl 0.24 0.67 plasma creatinine analysis by Jaffe reaction without deproteinization with spectrophotometric readout 0.0 0 Jaffe method colorimetric spectrometry % glomerulosclerosis 68007 751
ACI/Eur plasma albumin level unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. blood albumin amount male 173 days-180 days 8 29.4 g/l 0.5 1.41 bromocresol green-based urine albumin analysis with spectrophotometric readout 0.0 0 bromocresol green 68026 751
ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur plasma albumin level unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. blood albumin amount male 173 days-180 days 10 28.3 g/l 0.6 1.9 bromocresol green-based urine albumin analysis with spectrophotometric readout 0.0 0 bromocresol green 68027 751
ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur plasma albumin level unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. blood albumin amount male 173 days-180 days 9 28.7 g/l 0.6 1.8 bromocresol green-based urine albumin analysis with spectrophotometric readout 0.0 0 bromocresol green 68030 751
ACI.FHH-(D1Mit18-D1Mit8)(D14Mit11-D14Hmgc14b)(D14Rat65-D14Rat90)/Eur body weight unilateral nephrectomy van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. body mass not specified 168 days-175 days 12 304.0 g 2.0 6.93 body weighing method 0.0 unilateral nephrectomy 126 days 67901 832
ACI.FHH-(D1Rat384-D1Rat156)/Eur body weight unilateral nephrectomy then NG-nitroarginine methyl ester (10-21 ml/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. body mass not specified 168 days-175 days 11 267.0 g 11.0 36.48 body weighing method 0.0 unilateral nephrectomy 126 days 67908 832
ACI.FHH-(D1Mit18-D1Mit8)(D14Mit11-D14Hmgc14b)(D14Rat65-D14Rat90)/Eur body weight unilateral nephrectomy then NG-nitroarginine methyl ester (10-21 ml/kg/d) (for 126 days) van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. body mass not specified 168 days-175 days 2 286.0 g 1.0 1.41 body weighing method 0.0 unilateral nephrectomy 126 days 67909 832
ACI.FHH-(D1Rat324-D1Rat156)/Eur kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. kidney glomerulus integrity trait male 173 days-180 days 8 41.0 % 9.0 25.46 ex vivo light microscopy with histochemistry 0.0 0 % glomerulosclerosis 67961 751
SD body weight controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. body mass female 0 days 13 283.6 g 3.8 13.7 body weighing method 0.0 unx 97 days 100632 2499
SD creatinine clearance controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days) and enalapril (25 mg/l) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. glomerular filtration trait female 0 days 12 0.58 ml/min 0.05 0.17 serum creatinine analysis 0.0 unx 97 days 100645 2499
SHR/NCrlCrlj plasma angiotensin II level to plasma angiotensin I level ratio unilateral nephrectomy (for 42 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin II amount male 126 days 5 0.8 null 0.13 0.29 radioimmunoassay 0.0 unx 42 days blood ang II level 101278 2583
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 17 16.7 mmHg/ml/min 1.4 5.77 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99996 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 16 7.1 mmHg/ml/min 0.3 1.2 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99998 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 11 11.66 ml/d 1.01 3.34 metabolic cage urine volume measurement method 0.0 unx 168 days 100000 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 154 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 16 45.5 ml/d 5.04 20.16 metabolic cage urine volume measurement method 0.0 unx 168 days 100003 2378
SD body weight unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. body mass male 0 days 5 302.0 g 6.26 14.0 body weighing method 0.0 unx 13 days 101538 2602
SD change in body weight unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. body mass male 0 days 5 66.0 g 4.92 11.0 body weighing method 0.0 unx 13 days change from surgery weight 101542 2602
SD plasma renin activity level unilateral nephrectomy (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. renin activity male 0 days 11 4.3 ng/ml/h 0.63 2.08 radioimmunoassay 0.0 unx 13 days - 101564 2602
SD change in body weight unilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. body mass male 0 days 8 48.0 g 10.96 31.0 body weighing method 0.0 unx 28 days change from surgery weight 101610 2602
SD left kidney wet weight unilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney mass male 0 days 8 1.79 g 0.12 0.35 post excision weight measurement 0.0 unx 28 days 101614 2602
SD systolic blood pressure unilateral nephrectomy (for 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. arterial blood pressure trait male 0 days 8 undefined 201.0 mmHg 6.72 19.0 tail cuff plethysmography 0.0 unx 14 days 101615 2602
SD systolic blood pressure unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. arterial blood pressure trait male 0 days 8 undefined 208.0 mmHg 6.01 17.0 tail cuff plethysmography 0.0 unx 28 days 101617 2602
SD heart wet weight unilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. heart mass male 0 days 8 1.21 g 0.04 0.1 post excision weight measurement 0.0 unx 28 days 101620 2602
SD urine total protein excretion rate unilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. total urine protein amount male 0 days 8 243.0 mg/d 26.16 74.0 urine protein analysis 0.0 unx 28 days 101624 2602
SD adrenal gland weight unilateral nephrectomy (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. adrenal gland mass male 0 days 7 69.0 mg 3.4 9.0 post excision weight measurement 0.0 unx 28 days 101600 2602
SD kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney glomerulus integrity trait male 0 days 6 25.3 % 4.53 11.1 ex vivo light microscopy with histochemistry 0.0 unx 28 days 101606 2602
SHR/NCrlCrlj blood urea nitrogen level unilateral nephrectomy (for 42 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood urea nitrogen amount male 126 days 5 72.0 mg/dl 5.0 11.18 blood urea nitrogen analysis 0.0 unx 42 days 101250 2583
SHR/NCrlCrlj creatinine clearance to body weight ratio unilateral nephrectomy (for 14 days) then controlled hydralazine content drinking water (15 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. glomerular filtration trait male 98 days 6 0.33 ml/min/100g 0.06 0.15 blood creatinine analysis 0.0 unx 14 days 101257 2583
SHR/NCrlCrlj creatinine clearance to body weight ratio unilateral nephrectomy (for 42 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. glomerular filtration trait male 126 days 5 0.14 ml/min/100g 0.03 0.06 blood creatinine analysis 0.0 unx 42 days 101258 2583
SHR/NCrlCrlj creatinine clearance to body weight ratio unilateral nephrectomy (for 42 days) then controlled candesartan content drinking water (1 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. glomerular filtration trait male 126 days 8 0.33 ml/min/100g 0.05 0.15 blood creatinine analysis 0.0 unx 42 days 101259 2583
SHR/NCrlCrlj creatinine clearance to body weight ratio unilateral nephrectomy (for 42 days) then controlled delapril content drinking water (30 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. glomerular filtration trait male 126 days 9 0.33 ml/min/100g 0.03 0.1 blood creatinine analysis 0.0 unx 42 days 101260 2583
SHR/NCrlCrlj plasma aldosterone level unilateral nephrectomy (for 42 days) then controlled candesartan content drinking water (1 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood aldosterone amount male 126 days 8 492.0 pg/ml 46.0 130.11 plasma aldosterone analysis 0.0 unx 42 days 101267 2583
SHR/NCrlCrlj plasma angiotensin II level unilateral nephrectomy (for 42 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood angiotensin II amount male 126 days 5 11.6 pg/ml 2.1 4.7 radioimmunoassay 0.0 unx 42 days blood ang II level 101274 2583
MW blood urea nitrogen level unilateral nephrectomy (for 70 days) then puromycin aminonucleoside (100 mg/kg) then puromycin aminonucleoside (40 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. blood urea nitrogen amount male 0 days 6 41.0 mg/dl 3.0 7.35 blood urea nitrogen analysis 0.0 unx 70 days 101186 2581
MW urine total protein excretion rate unilateral nephrectomy (for 14 days) then puromycin aminonucleoside (100 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. total urine protein amount male 0 days 6 7.0 mg/d 1.0 2.45 Bradford protein assay 0.0 unx 14 days 101191 2581
MW urine total protein excretion rate unilateral nephrectomy (for 14 days) and captopril (500 mg/l) (for 14 days) then puromycin aminonucleoside (100 mg/kg) Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. total urine protein amount male 0 days 5 10.0 mg/d 2.0 4.47 Bradford protein assay 0.0 unx 14 days 101193 2581
SHR/NCrlCrlj blood sodium level unilateral nephrectomy (for 42 days) then controlled delapril content drinking water (30 mg/kg/d) (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood sodium amount male 126 days 9 140.0 mmol/l 1.0 3.0 automated serum sodium test 0.0 unx 42 days 101240 2583
ACI.FHH-(rs198076037-rs105278863)/Mcwi urine total protein excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. total urine protein amount male 91 days 5 154.55 mg/d 13.31 29.76 urine protein analysis 0.0 unx 56 days rf-1-7 100058 2400
ACI/EurMcwi urine albumin excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. urine albumin amount male 91 days 9 19.16 mg/d 5.53 16.59 urine albumin analysis 0.0 unx 56 days 100059 2400
ACI.FHH-(rgdv393055223-rs198922144)/Mcwi urine albumin excretion rate unilateral nephrectomy then NG-nitroarginine methyl ester (150 mg/l) (for 56 days) Lazar J, et al., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18. urine albumin amount male 91 days 7 74.0 mg/d 8.91 23.57 urine albumin analysis 0.0 unx 56 days rf-1-4 100063 2400
WKY body weight unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 7 268.0 g 13.0 34.39 body weighing method 0.0 unx 28 days 99935 2378
WKY body weight unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 8 236.0 g 7.0 19.8 body weighing method 0.0 unx 28 days 99937 2378
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 8 352.0 mg/dl 17.0 48.08 machine read blood glucose test strip 0.0 unx 28 days 99942 2378
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 6 0.5 ml/min/100g 0.02 0.06 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99949 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 8 3.09 ml/min/100g 0.18 0.51 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99951 2378
SBH/Ygl urine total protein excretion rate unilateral nephrectomy (for 120 days) Yagil Y, et al., Physiol Genomics. 2010 Nov 29;42A(4):301-16. Epub 2010 Sep 28. total urine protein amount male 140 days 6 212.0 mg/d 23.0 56.34 urine protein analysis 0.0 0 106685 3037
SHR-Chr 8MWF/Rkb body weight unilateral nephrectomy (for 126 days) Schulz A, etal., Physiol Genomics. 2012 Jan 18;44(1):110-6. Epub 2011 Nov 22. body mass male 168 days 15 336.5 g 6.7 25.95 body weighing method 0.0 0 109552 3148
WKY heart weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. heart mass male 0 days 16 3.1 g/kg 0.1 0.4 post excision weight measurement 0.0 unx 150 days 107453 2378
WKY body weight unilateral nephrectomy (for 150 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 11 408.0 g 10.0 33.17 body weighing method 0.0 unx 150 days 107445 2378
WKY left kidney wet weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney mass male 0 days 17 9.9 mg/g 0.7 2.89 post excision weight measurement 0.0 unx 150 days 107456 2378
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then bosentan (100 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 17 11.8 x 10E3 um2 2.9 11.96 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107512 2378
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 11 12.6 x 10E3 um2 3.8 12.6 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107460 2378
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 136 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 16 15.8 x 10E3 um2 4.0 16.0 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107463 2378
ACI/Eur body weight unilateral nephrectomy van Dijk SJ, et al., Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12. body mass not specified 168 days-175 days 12 314.0 g 3.0 10.39 body weighing method 0.0 unilateral nephrectomy 126 days 67899 832
ACI/Eur body weight unilateral nephrectomy Shiozawa M, et al., J Am Soc Nephrol 2000 Nov;11(11):2068-78. body mass male 91 days-98 days 21 242.0 g 3.06 14.0 body weighing method 0.0 unilateral nephrectomy 39 days performed at 5 to 6 weeks of age 69139 1128
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 11 0.52 ml/min/100g 0.01 0.04 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99980 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 17 1.72 ml/min/100g 0.11 0.45 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99991 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 11 6.3 mmHg/ml/min 0.4 1.33 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99995 2378
MW body weight unilateral nephrectomy (for 70 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. body mass male 0 days 7 286.0 g 9.0 23.81 body measuring method 0.0 unx 70 days 101154 2581
MW blood urea nitrogen level unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. blood urea nitrogen amount male 0 days 7 25.0 mg/dl 1.0 2.65 blood urea nitrogen analysis 0.0 unx 14 days 101178 2581
MW blood urea nitrogen level unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. blood urea nitrogen amount male 0 days 7 25.0 mg/dl 3.0 7.94 blood urea nitrogen analysis 0.0 unx 42 days 101182 2581
MW glomerular filtration rate unilateral nephrectomy (for 70 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. glomerular filtration trait male 0 days 7 1.46 ml/min 0.08 0.21 inulin analysis by liquid phase colorimetry 0.0 unx 70 days 101205 2581
SD body weight controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then enalapril (25 mg/l) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. body mass female 0 days 12 281.9 g 4.2 14.55 body weighing method 0.0 unx 97 days 100633 2499
SD left kidney wet weight unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney mass male 0 days 5 1.16 g 0.11 0.25 post excision weight measurement 0.0 unx 13 days remnant kidney 101545 2602
SD systolic blood pressure unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. arterial blood pressure trait male 0 days 5 undefined 125.0 mmHg 6.26 14.0 tail cuff plethysmography 0.0 unx 13 days 101549 2602
SD urine total protein excretion rate unilateral nephrectomy (for 14 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. total urine protein amount male 0 days 8 201.0 mg/d 31.47 89.0 urine protein analysis 0.0 unx 14 days 101621 2602
SD kidney sclerotic glomeruli count to total glomeruli count ratio unilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. kidney glomerulus integrity trait male 0 days 8 26.0 % 3.89 11.0 ex vivo light microscopy with histochemistry 0.0 unx 28 days 101630 2602
SD adrenal gland weight unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. adrenal gland mass male 0 days 6 60.0 mg 3.27 8.0 post excision weight measurement 0.0 unx 28 days 101602 2602
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then enalapril (10 mg/kg/d) (for 14 days) and bosentan (100 mg/kg/d) (for 14 days) Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 6 2.42 ml/min/100g 0.09 0.22 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99954 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 7 12.38 ml/d 2.02 5.33 metabolic cage urine volume measurement method 0.0 unx 28 days 99965 2378