Phenominer Database Results (963 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
Hsd:WI spleen wet weight vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. spleen mass male 119 days-126 days 5 0.71 g 0.03 0.07 post excision weight measurement 0.0 0 76115 1545
Hsd:WI kidney glutathione peroxidase activity to total protein level ratio vehicle control condition (for 10 days) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney glutathione peroxidase activity male 0 days 6 22.63 U/mg 1.35 3.3 liquid phase colorimetry 0.0 0 76191 1544
Hsd:WI kidney glutathione peroxidase activity to total protein level ratio vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney glutathione peroxidase activity male 0 days 6 7.54 U/mg 0.51 1.24 liquid phase colorimetry 0.0 0 76192 1544
HanTac:WH body weight vehicle control condition (for 1 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. body mass male 1 days 17 6.2 g 0.12 0.5 body weighing method 0.0 0 96612 1559
HanTac:WH areola mammae/nipple number vehicle control condition (for 14 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. nipple quantity male 14 days 17 0.1 null 0.05 0.2 in vivo visual assessment 0.0 0 96627 1559
BluHsd:LE both testes wet weight vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. testis mass male 98 days 8 3.4 g 0.2 0.57 post excision weight measurement 0.0 0 76249 1543
BluHsd:LE total food calorie intake rate controlled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. eating behavior trait male 71 days-98 days 8 2995.2 kcal/d 187.0 528.92 unspecified method 0.0 0 76182 1543
Hsd:WI serum calcium level vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. blood calcium amount male 119 days-126 days 5 12.82 mg/dl 0.24 0.53 liquid phase colorimetry 0.0 0 76141 1545
BluHsd:LE serum estradiol level vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. blood estradiol amount male 98 days 8 370.0 pg/ml 120.0 339.41 radioimmunoassay 0.0 0 tritium-based 76254 1543
WKY/Izm absolute change in mean arterial blood pressure air-jet exposure (for 0 hours) then vehicle control condition (2 ul) (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 -3.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84553 1120
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure air-jet exposure (for 0 hours) then vehicle control condition (2 ul) (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 -1.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84555 1120
Hsd:WI timed urine volume vehicle control condition (for 10 days) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. urine output male 0 days 6 6.8 ml/d 0.61 1.5 urine volume measurement method 0.0 0 75965 1544
Hsd:WI serum urea nitrogen level vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. blood urea nitrogen amount male 0 days 6 96.11 mg/dl 1.91 4.69 liquid phase colorimetry 0.0 0 75977 1544
Hsd:WI body weight vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. body mass male 119 days-126 days 5 388.0 g 16.82 37.6 body weighing method 0.0 0 76041 1545
WKY/Izm absolute change in mean arterial blood pressure vehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 27.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 84566 1120
HanTac:WH thyroid gland wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. thyroid gland mass female 16 days-17 days 15 4.7 mg 0.23 0.9 post excision weight measurement 0.0 0 left ovary 96707 1559
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in heart rate air-jet exposure (for 0 hours) then vehicle control condition (2 ul) (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. heart pumping trait male 98 days 6 -5.0 beats/min 7.0 17.15 vascular indwelling catheter method 0.0 0 84564 1120
HanTac:WH right testis wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. testis mass male 16 days-17 days 18 51.3 mg 1.79 7.6 post excision weight measurement 0.0 0 96637 1559
HanTac:WH both seminal vesicles wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. seminal gland mass male 16 days-17 days 18 7.1 mg 0.47 2.0 post excision weight measurement 0.0 0 96657 1559
HanTac:WH combined levator ani and bulbocavernosus muscle weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. skeletal muscle mass male 16 days-17 days 18 26.0 mg 1.04 4.4 post excision weight measurement 0.0 0 96662 1559
HanTac:WH both adrenal glands wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. adrenal gland mass male 16 days-17 days 18 7.5 mg 0.49 2.1 post excision weight measurement 0.0 0 96677 1559
SD mean arterial blood pressure sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. arterial blood pressure trait male 0 days 6 86.0 mmHg 4.0 9.8 vascular transducer tipped catheter 1.0 sham ACF 2 days 98815 2160
SHRSP.WKY-(D3Wox20-D3Rat114)/Gcrc heart weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart mass male 126 days 6 4.47 g/kg 0.27 0.66 post excision weight measurement 0.0 0 102103 2646
SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc heart left ventricle weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart left ventricle mass male 126 days 0 3.04 mg/g 0.29 post excision weight measurement 0.0 0 102111 2646
SHRSP.WKY-(D3Wox20-D3Rat114)/Gcrc heart left ventricle weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart left ventricle mass male 126 days 6 3.33 mg/g 0.33 0.81 post excision weight measurement 0.0 0 102112 2646
SHRSP/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 4.11 g/kg 0.25 post excision weight measurement 0.0 0 102118 2646
SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 3.65 g/kg 0.2 post excision weight measurement 0.0 0 102120 2646
SS/NEisSlc heart left ventricle end-diastolic diameter controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. heart left ventricle end-diastolic diameter male 126 days 8 8.7 mm 0.3 0.85 transthoracic echocardiography 0.0 0 102320 2684
SS/NEisSlc both kidneys wet weight to body weight ratio controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. kidney mass male 126 days 8 5.19 g/kg 0.19 0.54 post excision weight measurement 0.0 0 102323 2684
SS/NEisSlc serum urea nitrogen level controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. blood urea nitrogen amount male 126 days 8 33.6 mg/dl 4.1 11.6 serum urea nitrogen analysis 0.0 0 102329 2684
SS/NEisSlc timed urine volume controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. urine output male 126 days 8 53.6 ml/d 7.1 20.08 urine volume measurement method 0.0 0 102335 2684
LH/Mav body weight vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. body mass male 112 days 11 384.0 g 9.0 29.85 body weighing method 0.0 0 102724 2721
GK serum fructosamine level vehicle control condition (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood fructosamine amount male 175 days 6 187.0 umol/l 9.0 22.05 serum fructosamine analysis 0.0 0 103504 2827
GK blood glucose level vehicle control condition (for 28 days) then fasting (for 16 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood glucose amount male 168 days 6 122.0 mg/dl 8.0 19.6 blood glucose test strip read by electrochemical glucometer 0.0 0 103512 2827
WF/Mol body weight gain vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 5 23.0 g 3.0 6.71 body weighing method 0.0 sham acf 7 days change from surgery weight 101343 2585
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 17 0.5 ml/min/100g 0.03 0.12 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99981 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 11 2.28 ml/min/100g 0.07 0.23 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99990 2378
GK/Slc blood free fatty acids level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood free fatty acid amount male 105 days 0 12.55 mg/dl 0.52 blood free fatty acid analysis 0.0 0 ueq/l = umol/l 102884 2781
Slc:W blood total cholesterol level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood cholesterol amount male 105 days 0 67.0 mg/dl 3.5 blood cholesterol analysis 0.0 0 n=4-6 102890 2781
Slc:W urine glucose level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. urine glucose amount male 105 days 0 31.8 mg/dl 3.4 blood glucose test strip read by electrochemical glucometer 0.0 0 n=4-6 102926 2781
WKY body weight left anterior descending coronary artery occlusion then vehicle control condition Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. body mass male 42 days-56 days 30 225.0 g 1.8 9.86 body weighing method 0.0 lad occlusion 0 days 100269 2460
WKY lung wet weight left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. lung mass male 238 days-252 days 30 2.13 g 0.13 0.71 post excision weight measurement 0.0 lad occlusion 196 days 100299 2460
SD serum creatinine level controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. blood creatinine amount female 0 days 13 1.65 mg/dl 0.14 0.5 serum creatinine analysis 0.0 unx 97 days 100637 2499
SD serum parathyroid hormone level controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. blood parathyroid hormone amount female 0 days 13 3496.0 pg/ml 862.0 3107.99 serum parathyroid hormone analysis 0.0 unx 97 days 100647 2499
Crl:CD(SD) urine total protein excretion rate control condition (for 28 days) then vehicle control condition (for 84 days) Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. total urine protein amount male 112 days 5 36.7 mg/d 3.5 7.83 urine protein analysis 0.0 0 100768 2521
PCK-Pkhd1pck/CrljCrl urine protein level to urine creatinine level ratio control condition (for 28 days) then vehicle control condition (for 84 days) Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. total urine protein amount male 112 days 6 12.0 null 1.7 4.16 urine protein analysis 0.0 0 100769 2521
LL/Mav systolic blood pressure vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. arterial blood pressure trait male 112 days 9 mean of 3 samples of undefined duration serial mean 119.0 mmHg 4.0 12.0 tail cuff plethysmography 0.0 0 102726 2721
LH/Mav urine albumin excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 11 24.0 mg/d 4.6 15.26 urine albumin analysis 0.0 0 102740 2721
LL/Mav urine albumin level to urine total protein level ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 9 11.9 % 0.7 2.1 urine albumin analysis 0.0 0 102742 2721
LL/Mav urine creatinine excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine creatinine amount male 112 days 9 11.1 mg/d 0.5 1.5 urine creatinine analysis 0.0 0 102746 2721
LL/Mav aorta weight to body weight ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. aorta mass male 112 days 9 11.2 mg/100g 0.2 0.6 post excision weight measurement 0.0 0 102770 2721
SS-Nppbem2Mcwi-/- heart left ventricle end-systolic diameter vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-systolic diameter male 168 days 7 4.83 mm 0.35 0.93 echocardiography 0.0 0 99788 2319
GK mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 5 undefined 137.0 mmHg 6.0 13.42 vascular transducer tipped catheter 0.0 0 103017 2784
GK mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 147.0 mmHg 7.0 18.52 vascular transducer tipped catheter 0.0 0 103018 2784
GK mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 140.0 mmHg 8.0 21.17 vascular transducer tipped catheter 0.0 0 103030 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 6 undefined 120.0 mmHg 7.0 17.15 vascular transducer tipped catheter 0.0 0 103031 2784
Crlj:WI heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 6 90.0 beats/min 15.0 36.74 vascular transducer tipped catheter 0.0 0 103039 2784
Crlj:WI heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) then meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 6 288.0 beats/min 11.0 26.94 vascular transducer tipped catheter 0.0 0 103047 2784
Crlj:WI heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 6 275.0 beats/min 8.0 19.6 vascular transducer tipped catheter 0.0 0 103051 2784
Crlj:WI heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 264.0 beats/min 9.0 23.81 vascular transducer tipped catheter 0.0 0 103052 2784
WF/Mol systolic blood pressure vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. arterial blood pressure trait male 0 days 5 undefined 165.0 mmHg 7.0 15.65 tail cuff plethysmography 0.0 sham acf 7 days 101365 2585
WF/Mol heart rate vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 7 450.0 beats/min 13.0 34.39 tail cuff plethysmography 0.0 acf 7 days 101372 2585
WF/Mol heart rate vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 5 358.0 beats/min 12.0 26.83 tail cuff plethysmography 0.0 sham acf 7 days 101373 2585
WF/Mol heart left ventricle weight vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart left ventricle mass male 0 days 7 0.28 g 0.0 0.01 post excision weight measurement 0.0 acf 4 days 101390 2585
SS-Nppbem2Mcwi-/- heart interventricular end-diastolic septal wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart ventricle septum thickness male 84 days 7 2.01 mm 0.08 0.21 echocardiography 0.0 0 99762 2319
SS-Nppbem2Mcwi-/- heart interventricular end-diastolic septal wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart ventricle septum thickness male 168 days 7 1.92 mm 0.12 0.32 echocardiography 0.0 0 99764 2319
MW urine total protein excretion rate vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. total urine protein amount male 0 days 18 8.0 mg/d 2.0 8.49 Bradford protein assay 0.0 control 29 days 101203 2581
SS.ZUC-Leprfa+/+/Slc heart ventricle septal wall thickness bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle wall thickness female 91 days 9 0.16 cm 0.0 0.01 echocardiography 0.0 ovariectomy 42 days 101707 2622
SD left ventricular end-diastolic blood pressure artificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart left ventricular blood pressure trait male 0 days 6 13.0 mmHg 2.0 4.9 vascular transducer tipped catheter 1.0 ACF 2 days 98826 2160
SD left ventricular end-systolic blood pressure sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart left ventricular blood pressure trait male 0 days 6 64.0 mmHg 3.0 7.35 vascular transducer tipped catheter 1.0 sham ACF 2 days 98839 2160
WKY/NCrl systolic blood pressure vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 126.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks nighttime measurement 103534 2827
WKY/NCrl diastolic blood pressure vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 85.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103542 2827
GK diastolic blood pressure vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 104.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks nighttime measurement 103552 2827
GK acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 96.96 % 2.2 6.22 wire myography 0.0 0 103608 2827
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -8.15 null 0.09 0.24 wire myography 0.0 0 103610 2827
OXYS/Nov neuron rough endoplasmic reticulum area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 11.2 % 0.33 0.66 ex vivo electron microscopy with digital image analysis 0.0 0 rer/cyto 103654 2844
WI neuron vacuole area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 3.97 % 0.34 0.68 ex vivo electron microscopy with digital image analysis 0.0 0 v/cyto 103656 2844
SS/NEisSlc systolic blood pressure controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. arterial blood pressure trait male 126 days 8 undefined 226.0 mmHg 11.0 31.11 tail cuff plethysmography 0.0 0 102314 2684
LL/Mav plasma triglyceride level vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood triglyceride amount male 112 days 13 1.58 mmol/l 0.13 0.47 plasma triglyceride analysis 0.0 0 102668 2703
LL/Mav plasma creatinine level vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood creatinine amount male 112 days 13 0.52 mg/dl 0.01 0.04 plasma creatinine analysis 0.0 0 102674 2703
LL/Mav heart left ventricle weight to body weight ratio vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. heart left ventricle mass male 112 days 13 20.4 mg/g 0.1 0.36 post excision weight measurement 0.0 0 102680 2703
LL/Mav aorta weight to body weight ratio vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. aorta mass male 112 days 13 11.6 mg/100g 0.3 1.08 post excision weight measurement 0.0 0 102686 2703
SS.ZUC-Leprfa-/-/Slc heart weight to tibia length ratio vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart mass male 91 days 13 0.43 g/cm 0.01 0.04 post excision weight measurement 0.0 0 101974 2644
SS.ZUC-Leprfa-/-/Slc heart left ventricle weight to tibia length ratio vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricle mass male 91 days 13 0.31 g/cm 0.01 0.03 post excision weight measurement 0.0 0 lv/tl 101977 2644
SS.ZUC-Leprfa-/-/Slc epididymal fat pad weight to tibia length ratio vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. epididymal fat pad mass male 91 days 13 3.55 g/cm 0.1 0.35 post excision weight measurement 0.0 0 ef/tl 101983 2644
SS.ZUC-Leprfa-/-/Slc mesenteric fat pad weight to tibia length ratio vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. mesenteric fat pad mass male 91 days 13 364.22 mg/mm 10.33 37.25 post excision weight measurement 0.0 0 mf/tl 101986 2644
SS.ZUC-Leprfa-/-/Slc inguinal fat pad weight to tibia length ratio vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. inguinal fat pad mass male 91 days 13 1501.32 mg/mm 68.53 247.09 post excision weight measurement 0.0 0 if/tl 101989 2644
LL/Mav systolic blood pressure vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. arterial blood pressure trait male 56 days 9 mean of 3 samples of undefined duration serial mean 115.0 mmHg 5.0 15.0 tail cuff plethysmography 0.0 0 102702 2721
WF/Mol heart rate vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 5 382.0 beats/min 8.0 17.89 tail cuff plethysmography 0.0 sham acf 7 days 101388 2585
WKY body weight vehicle control condition (1 null) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. body mass male 156 days 10 450.39 g 9.36 29.6 body weighing method 0.0 0 99107 2219
SS-Nppbem2Mcwi-/- mean arterial blood pressure vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. arterial blood pressure trait male 168 days 7 serial mean 158.0 mmHg 27.0 71.44 tail cuff plethysmography 0.0 0 99836 2319
SS-Nppbem2Mcwi-/- timed urine volume vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. urine output male 84 days 7 14.7 ml/d 2.6 6.88 urine volume measurement method 0.0 0 99840 2319
LH/Mav systolic blood pressure vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. arterial blood pressure trait male 49 days-56 days 8 undefined 136.0 mmHg 3.0 8.49 tail cuff plethysmography 0.0 0 102645 2703
WF/Mol heart left ventricle weight vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 5 0.06 g 0.0 0.0 post excision weight measurement 0.0 sham acf 4 days 101413 2585
WF/Mol heart right ventricle weight vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 5 0.06 g 0.0 0.0 post excision weight measurement 0.0 sham acf 7 days 101417 2585
WKY/NHsd skin chloride level to skin dry weight ratio standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin chloride amount male 0 days 7 0.05 mmol/g 0.0 0.01 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin cl mmol/g 99135 2238
WKY/NHsd skin chloride level to skin water level ratio standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin chloride amount male 0 days 7 42.0 mmol/l 2.4 6.35 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin cl/h2o 99151 2238
WKY/NHsd skin chloride level to skin water level ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin chloride amount male 0 days 7 48.0 mmol/l 4.8 12.7 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin cl/h2o 99153 2238
WKY/NHsd skin potassium level to skin water level ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin potassium amount male 0 days 7 71.0 mmol/l 3.0 7.94 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin k/h2o 99157 2238
WKY/NHsd plasma sodium level controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood sodium amount male 0 days 7 141.4 mmol/l 2.1 5.56 automated blood electrolyte analysis 0.0 0 99161 2238
WKY/NHsd plasma cystatin C level standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood cystatin C amount male 0 days 7 4.0 mg/l 0.6 1.59 automated plasma protein analysis 0.0 0 99175 2238
WKY/NHsd skin sodium level to skin dry weight ratio standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin sodium amount male 0 days 7 0.11 REQUEST NEW VALUE 0.0 0.01 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin mmol/g 99131 2238
WKY/NHsd plasma chloride level controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood chloride amount male 0 days 7 104.8 mmol/l 1.8 4.76 automated blood electrolyte analysis 0.0 0 99169 2238
SS-Nppbem2Mcwi-/- heart left ventricle weight vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle mass male 84 days 7 1.53 g 0.08 0.21 echocardiography 0.0 0 99810 2319
SS-Nppbem2Mcwi-/- heart left ventricle weight vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle mass male 252 days 7 1.78 g 0.04 0.11 echocardiography 0.0 0 99814 2319
SS-Nppbem2Mcwi-/- heart rate vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart pumping trait male 84 days 7 382.0 beats/min 45.0 119.06 echocardiography 0.0 0 99816 2319
SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc timed urine volume vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine output male 126 days 7 30.68 ml/d 11.32 29.95 metabolic cage urine volume measurement method 0.0 0 102134 2646
MWF/ZtmRrrc body weight vehicle control condition Remuzzi A, et al., J Clin Invest. 1990 Feb;85(2):541-9. body mass male 246 days 8 433.0 g 9.19 26.0 body weighing method 0.0 0 100905 2541
SS-Nppbem2Mcwi-/- heart left ventricle end-systolic posterior wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle posterior wall thickness male 168 days 7 3.17 mm 0.17 0.45 echocardiography 0.0 0 99794 2319
SS.ZUC-Leprfa-/-/Slc heart left ventricle posterior wall thickness bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle posterior wall thickness female 91 days 8 2.06 mm 0.04 0.11 echocardiography 0.0 ovariectomy 42 days 101713 2622
SS.ZUC-Leprfa-/-/Slc heart left ventricle end-diastolic diameter bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle end-diastolic diameter female 91 days 8 7.2 mm 0.14 0.4 echocardiography 0.0 ovariectomy 42 days 101717 2622
SS.ZUC-Leprfa+/+/Slc heart left ventricle fractional shortening bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle end-diastolic diameter female 91 days 9 39.8 % 2.5 7.5 echocardiography 0.0 ovariectomy 42 days 101719 2622
SS.ZUC-Leprfa-/-/Slc heart left ventricle relative wall thickness bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle wall thickness female 91 days 8 57.0 % 2.0 5.66 echocardiography 0.0 ovariectomy 42 days 101729 2622
SS.ZUC-Leprfa+/+/Slc heart isovolumetric relaxation time bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart muscle relaxation trait female 91 days 9 24.8 ms 1.8 5.4 echocardiography 0.0 ovariectomy 42 days 101735 2622
SS.ZUC-Leprfa-/-/Slc time constant of left ventricular pressure decay bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricular blood pressure trait female 91 days 8 47.3 ms 1.5 4.24 echocardiography 0.0 ovariectomy 42 days 101749 2622
WF/Mol body weight vehicle control condition then sham surgical control condition (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 6 200.0 g 2.0 4.9 body weighing method 0.0 2 days 101313 2585
WF/Mol body weight gain vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 7 -10.0 g 3.0 7.94 body weighing method 0.0 acf 4 days change from surgery weight 101324 2585
WKY body weight unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 7 268.0 g 13.0 34.39 body weighing method 0.0 unx 28 days 99935 2378
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 8 350.0 mg/dl 18.0 50.91 machine read blood glucose test strip 0.0 unx 28 days 99941 2378
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 7 0.49 ml/min/100g 0.03 0.08 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99945 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 8 3.09 ml/min/100g 0.18 0.51 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99951 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 7 0.23 null 0.01 0.03 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99955 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 7 10.0 mmHg/ml/min 0.6 1.59 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99960 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 8 23.47 ml/d 1.73 4.89 metabolic cage urine volume measurement method 0.0 unx 28 days 99966 2378
SS.ZUC-Leprfa-/-/Slc heart left ventricle fractional shortening vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricle end-diastolic diameter male 91 days 13 47.66 % 2.43 8.76 echocardiography 0.0 0 102007 2644
SS.ZUC-Leprfa-/-/Slc serum low density lipoprotein cholesterol level vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood LDL cholesterol amount male 91 days 6 102.5 mg/dl 9.37 22.95 serum low-density lipoprotein-cholesterol measurement test 0.0 0 101944 2644
SS.ZUC-Leprfa-/-/Slc serum high density lipoprotein cholesterol level vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood HDL cholesterol amount male 91 days 6 97.25 mg/dl 15.33 37.55 serum high-density lipoprotein-cholesterol measurement test 0.0 0 101947 2644
SS-Sod3m1Mcwi right atrium weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56 days 10 0.01 g 0.0 0.0 post excision weight measurement 0.0 0 106563 3032
SS/JrHsdMcwi left atrium weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left atrium mass male 56 days 7 0.01 g 0.0 0.0 post excision weight measurement 0.0 0 106566 3032
SS/JrHsdMcwi heart right atrium weight to left atrium weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56 days 7 1.09 null 0.09 0.24 post excision weight measurement 0.0 0 106570 3032
SS-Sod3m1Mcwi liver weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56 days 10 10.6 g 0.22 0.7 post excision weight measurement 0.0 0 106575 3032
SS/JrHsdMcwi heart right ventricle weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56 days 7 0.62 mg/g 0.03 0.08 post excision weight measurement 0.0 0 106582 3032
SS-Sod3m1Mcwi heart left ventricle weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left ventricle mass male 56 days 10 2.49 mg/g 0.03 0.09 post excision weight measurement 0.0 0 106587 3032
SS/JrHsdMcwi lung weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56 days 7 0.4 % 0.08 0.2 post excision weight measurement 0.0 0 106590 3032
SS/JrHsdMcwi single kidney wet weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. kidney mass male 56 days 7 8.14 g/kg 0.11 0.29 post excision weight measurement 0.0 0 106606 3032
SS-Sod3m1Mcwi heart right ventricle weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56 days 10 4.33 mg/mm 0.97 3.07 post excision weight measurement 0.0 0 106611 3032
SS-Sod3m1Mcwi lung weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56 days 10 0.33 g/cm 0.0 0.01 post excision weight measurement 0.0 0 106619 3032
SD aqueous humor uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35 days-49 days 3 5.95 % 0.38 0.66 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index aqueous humor molecular composition trait 106132 3028
SD brain uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 35 days-49 days 3 2.12 % 0.12 0.21 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106150 3028
SD serum total immunoglobulin E level vehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days) Zhuang ZM, et al., Int J Clin Exp Med. 2015 May 15;8(5):6866-77. eCollection 2015. blood immunoglobulin E amount not specified 0 days 4 0.2 ug/l 0.0 0.0 enzyme linked immunosorbent assay 0.0 0 error not defined 105407 3015
Hsd:SD thymus weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. thymus mass female 84 days 10 1.5 mg/g 0.35 1.11 post excision weight measurement 0 105884 3021
Hsd:SD blood hemoglobin level vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 14.05 g/dl 0.48 1.52 automated hematology analysis 0 105944 3021
SD-Ahrem2Sage blood hemoglobin level vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 14.01 g/dl 0.62 1.96 automated hematology analysis 0 105945 3021
SD-Ahrem2Sage mean corpuscular volume vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte size trait female 84 days 10 58.44 fl 0.87 2.75 automated hematology analysis 0 105969 3021
Hsd:SD mean corpuscular hemoglobin vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 18.82 pg 0.44 1.39 automated hematology analysis 0 105980 3021
SD serum interleukin-4 level vehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days) Zhuang ZM, et al., Int J Clin Exp Med. 2015 May 15;8(5):6866-77. eCollection 2015. blood interleukin-4 amount not specified 0 days 4 0.14 ug/l 0.01 0.01 enzyme linked immunosorbent assay 0.0 0 error not defined 105411 3015
SD serum interleukin-9 level vehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days) Zhuang ZM, et al., Int J Clin Exp Med. 2015 May 15;8(5):6866-77. eCollection 2015. blood interleukin-9 amount not specified 0 days 4 0.1 ug/l 0.01 0.01 enzyme linked immunosorbent assay 0.0 0 error not defined 105415 3015
Crl:CD(SD) retinal outer layer thickness vehicle control condition (0 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67 days-74 days 5 138.5 um 3.4 7.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography outer retinal layer 105474 3016
Crl:CD(SD) retinal outer layer thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136 days-143 days 5 129.8 um 4.02 9.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography outer retinal layer 105498 3016
Hsd:SD white blood cell count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. leukocyte quantity female 84 days 10 9.42 x 1000 cells/ul 2.25 7.12 automated hematology analysis 0 106016 3021
Crl:CD(SD) full retina thickness vehicle control condition (0 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59 days-66 days 5 129.7 um 3.71 8.3 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 full retina layer 105438 3016
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59 days-66 days 5 131.6 um 4.87 10.9 optical coherence tomography 0.0 0 optical coherence tomography inner retinal layer 105470 3016
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67 days-74 days 5 128.7 um 4.92 11.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography inner retinal layer 105478 3016
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111 days-118 days 5 121.9 um 4.38 9.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography inner retinal layer 105494 3016
SS-Sod3m1Mcwi heart rate vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart pumping trait male 56 days 8 354.0 beats/min 12.9 36.49 vascular fluid filled catheter 0.0 0 106799 3032
SS/JrHsdMcwi mean aortic pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56 days 6 94.4 mmHg 4.27 10.46 vascular fluid filled catheter 0.0 0 Mean aortic pressure 106810 3032
SS-Sod3m1Mcwi mean aortic pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56 days 8 94.5 mmHg 5.02 14.2 vascular fluid filled catheter 0.0 0 Mean aortic pressure 106811 3032
BDIX/CrCrl total white blood cell count DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. leukocyte quantity male 92 days 10 10.0 x 1000 cells/ul 0.35 1.1 automated total white blood cell count test 0.0 0 WBC 107828 3097
BDIX/CrCrl red blood cell distribution width-coefficient of variation DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. erythrocyte size trait male 92 days 10 17.7 % 0.13 0.4 automated hematology analysis 0.0 0 MCV, RDW% 107848 3097
BDIX/CrCrl blood lymphocyte count to total leukocyte count ratio DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. lymphocyte quantity male 92 days 10 8.0 % 0.09 0.3 automated differential white blood cell count test 0.0 0 LYM 107853 3097
BDIX/CrCrl serum triglyceride level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood triglyceride amount male 92 days 10 249.0 mg/dl 6.96 22.0 automated serum analysis 0.0 0 serum triglyceride level 107899 3097
SHRSP/A3NCrl systolic blood pressure controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. arterial blood pressure trait male 161 days-175 days 6 162.0 mmHg 4.0 9.8 tail cuff plethysmography 0.0 0 107385 3083
WAG/Nov G0 stage diploid thymocyte count to total thymocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. T cell development trait male 150 days-180 days 10 93.31 % 0.93 2.94 flow cytometry method 0.0 IP injection 1 days saline 107709 3096
WAG/Nov CD4+CD25- splenocyte count to total splenocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 27.9 % 0.69 2.18 flow cytometry method 0.0 IP injeciton 1 days saline cd4+cd25- spleen 107730 3096
ISIAH CD11b/c+ splenocyte count to total splenocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 8.4 % 1.11 3.51 flow cytometry method 0.0 IP injeciton 1 days saline cd11b/c+ spleen 107748 3096
ISIAH CD3+ splenocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 214.09 x10E6/organ 11.49 36.33 flow cytometry method 0.0 IP injeciton 1 days saline cd3+ spleen 107757 3096
ISIAH CD11b/c+ splenocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 50.17 x10E6/organ 10.65 33.68 flow cytometry method 0.0 IP injeciton 1 days saline cd11b/c+ spleen 107760 3096
ISIAH CD4+CD25+ thymocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymocyte quantity male 150 days-180 days 10 32.19 x10E6/organ 7.15 22.61 flow cytometry method 0.0 IP injeciton 1 days saline cd4+cd25+ t-cell 107772 3096
WAG/Nov plasma triglyceride level vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. blood triglyceride amount male 150 days-180 days 10 1.19 mmol/l 0.09 0.29 plasma triglyceride analysis 0.0 IP injeciton 1 days saline 107775 3096
BDIX/CrCrl platelet count DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. platelet quantity male 92 days 10 815.0 x 1000 /ul 2.53 8.0 automated platelet count test 0.0 0 platelet, plateletcrit 107818 3097
BDIX/CrCrl total white blood cell count DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. leukocyte quantity male 71 days 10 12.9 x 1000 cells/ul 0.63 2.0 automated total white blood cell count test 0.0 0 WBC 107826 3097
WAG/Nov thymus weight to body weight ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymus mass male 150 days-180 days 10 0.77 mg/g 0.09 0.28 post excision weight measurement 0.0 IP injeciton 1 days saline 107688 3096
ISIAH thymus weight to body weight ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymus mass male 150 days-180 days 10 1.95 mg/g 0.77 2.43 post excision weight measurement 0.0 IP injeciton 1 days saline 107689 3096
SHRSP/A3N kidney total tubule cast count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 349.0 /section 45.0 ex vivo light microscopy with histochemistry 0.0 0 107555 3090
ISIAH spleen cell count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. spleen morphology trait male 150 days-180 days 10 583.56 x10E6/organ 109.7 346.9 isolated cell counting method 0.0 IP injection 1 days saline 107703 3096
MWF/FubRkb heart rate vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. heart pumping trait male 112 days 10 352.3 beats/min 7.3 23.08 tail cuff plethysmography heart 0.0 0 109413 3140
MWF/FubRkb mesenteric artery adventitial thickness vehicle control condition Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. mesenteric artery morphology trait male 114 days 10 8.6 um 0.7 2.21 confocal microscopy 0.0 0 109425 3140
Hsd:SD scotopic B wave amplitude of ERG waveform vehicle control condition (2 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. rod electrophysiology trait both 0 days 4 338.0 uV electroretinography cornea 0.0 subretinal injection 30 days scotopic b-wave ERG 108640 3128
BDIX/CrCrl red blood cell count DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. erythrocyte quantity male 71 days 10 11.0 x 10E6 cells/ul 0.41 1.3 automated blood cell counting method 0.0 0 red blood cell count, hematocrit 107801 3097
BDIX/CrCrl mean corpuscular volume DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. erythrocyte size trait male 92 days 10 47.5 fl 0.19 0.6 automated hematology analysis 0.0 0 MCV, RDW% 107808 3097
BDIX/CrCrl platelet distribution width DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. platelet size trait male 71 days 10 8.7 fl 0.16 0.5 automated hematology analysis 0.0 0 107882 3097
BDIX/CrCrl red blood cell count DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. erythrocyte quantity male 92 days 10 10.7 x 10E6 cells/ul 0.25 0.8 automated blood cell counting method 0.0 0 red blood cell count, hematocrit 107803 3097
SS/NEisSlc time to first movement outside a discrete space in an experimental apparatus vehicle control condition (for 547.5 days) then tactile electric shock exposure (500 mA) (for 0 hours) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. locomotor behavior trait not specified 63 days-236 days 10 235.0 s 50.0 158.11 passive avoidance test using a two-way shuttle box apparatus 0.0 electric foot shock 18 days passive avoidance test using a two-way shuttle box apparatus (MMO:000072) 107468 2339
BDIX/CrCrl serum total bilirubin level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood bilirubin amount male 92 days 10 0.35 mg/dl 0.16 0.5 automated serum analysis 0.0 0 serum bilirubin 107926 3097
WKY left kidney wet weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney mass male 0 days 17 9.9 mg/g 0.7 2.89 post excision weight measurement 0.0 unx 150 days 107456 2378
BDIX/CrCrl serum aspartate aminotransferase activity level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood aspartate transaminase amount male 92 days 10 193.0 U/l 8.22 26.0 automated serum analysis 0.0 0 serum aspartate aminotransferase 107904 3097
LOU/MWsl serum albumin level rat IgM immunocytoma cells (0.01 x 10E6 cells) (for 18 days) then vehicle control condition (1 ml/kg) (for 7 days) van Hoesel QG, etal., J Natl Cancer Inst. 1984 May;72(5):1141-50. blood albumin amount male 109 days 5 219.0 g/dl 13.86 31.0 gel electrophoresis 0.0 0 109761 3155
BDIX/CrCrl blood granulocyte count DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. granulocyte quantity male 71 days 10 8.7 x 1000 cells/ul 0.25 0.8 automated differential white blood cell count test 0.0 0 107866 3097
BDIX/CrCrl blood granulocyte count DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. granulocyte quantity male 92 days 10 7.3 x 1000 cells/ul 0.03 0.1 automated differential white blood cell count test 0.0 0 107868 3097
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 17 13.2 x 10E3 um2 3.3 13.61 ex vivo light microscopy with histochemistry 0.0 unx 150 days 107511 2378
Crl:WI tibia length vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. tibia length male 113 days 10 4.0 cm 1.0 3.16 post excision length measurement 0.0 0 109395 3140
MWF/FubRkb tibia length vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. tibia length male 113 days 10 4.2 cm 1.0 3.16 post excision length measurement 0.0 0 109397 3140
BluHsd:LE body weight vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. body mass male 70 days 8 345.8 g 13.1 37.05 body weighing method 0.0 0 76140 1543
Hsd:WI kidney catalase activity to total protein level ratio vehicle control condition (for 10 days) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. catalase activity male 0 days 6 35.98 nmol/mg 0.81 1.98 liquid phase colorimetry 0.0 0 76234 1544
SS-Sod3m1Mcwi heart right atrium weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56 days 10 0.06 mg/g 0.01 0.03 post excision weight measurement 0.0 0 106595 3032
Hsd:WI both kidneys wet weight vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney mass male 0 days 6 1.2 g 0.05 0.13 post excision weight measurement 0.0 0 75957 1544
LL/Mav plasma triglyceride level vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood triglyceride amount male 112 days 9 1.4 mmol/l 0.11 0.33 plasma triglyceride analysis 0.0 0 102754 2721
LH/Mav heart left ventricle weight to body weight ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. heart left ventricle mass male 112 days 11 2.24 mg/g 0.0 0.01 post excision weight measurement 0.0 0 102768 2721
SD-Abcb1aem1Sage-/- brain uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 42 days-56 days 3 14.0 % 7.3 12.64 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106162 3028
SD aqueous humor uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. REQUEST NEW TERM (00:0000000) male 35 days-49 days 3 8.46 % 0.61 1.06 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index aqueous humor molecular composition trait 106138 3028
WI cerebrum infarct volume to total cerebrum volume ratio isoflurane (1.5 %) (for 4 hours) then vehicle control condition then embolism injection of middle cerebral artery (for 1 days) Yang F, et al., J Pharm Pharm Sci. 2014;17(3):362-70. cerebrum integrity trait male 0 days 16 23.0 % 3.0 12.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 cerebral ischemia 1 days 106358 3029
SD mean arterial blood pressure artificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. arterial blood pressure trait male 0 days 6 72.0 mmHg 2.0 4.9 vascular transducer tipped catheter 1.0 ACF 2 days 98814 2160
LH/Mav renal vascular resistance to kidney weight ratio vehicle control condition then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. kidney blood vessel physiology trait male 84 days 8 SBP/RBF 33.0 ml/min/g/mmHg 2.0 5.66 ultrasonic flowmeter 0.0 0 102857 2761
GK body weight vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. body mass male 168 days 6 380.0 g 7.0 17.15 body weighing method 0.0 0 103492 2827
SS/NEisSlc urine total protein excretion rate vehicle control condition (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. total urine protein amount not specified 547 days 10 215.9 mg/d 15.3 48.38 urine total protein analysis 0.0 0 107437 2339
Crlj:WI heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 415.0 beats/min 10.0 26.46 vascular transducer tipped catheter 0.0 0 103036 2784
GK heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 5 366.0 beats/min 17.0 38.01 vascular transducer tipped catheter 0.0 0 103041 2784
Crlj:WI heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 6 351.0 beats/min 19.0 46.54 vascular transducer tipped catheter 0.0 0 103043 2784
SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc urine urea level to urine creatinine level ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 7 101.15 null 8.47 22.41 urine urea analysis 0.0 0 103794 2646
SS.ZUC-Leprfa-/-/Slc inguinal fat pad weight to tibia length ratio bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. inguinal fat pad mass female 91 days 8 209.0 mg/mm 12.0 33.94 post excision weight measurement 0.0 ovariectomy 42 days sf/tl 101705 2622
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 17 39.46 ml/d 4.61 19.0 metabolic cage urine volume measurement method 0.0 unx 168 days 100001 2378
OXYS/Nov neuron vacuole area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 8.23 % 0.4 0.8 ex vivo electron microscopy with digital image analysis 0.0 0 v/cyto 103657 2844
WF/Mol heart right ventricle weight vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 6 0.05 g 0.0 0.0 post excision weight measurement 0.0 sham acf 7 days 101431 2585
WF/Mol body weight vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 5 180.0 g 2.0 4.47 body weighing method 0.0 7 days 101307 2585
WKY/NHsd skin potassium level plus skin sodium level to skin water level ratio standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin mineral amount male 0 days 7 0.17 null 0.0 0.0 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin na+k/h2o 99143 2238
WKY/NHsd skin potassium level plus skin sodium level to skin water level ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin mineral amount male 0 days 7 0.18 null 0.01 0.02 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin na+k/h2o 99145 2238
WKY/NHsd skin chloride level to skin water level ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin chloride amount male 0 days 7 101.0 mmol/l 3.9 10.32 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin na/h2o 99149 2238
WKY/Gcrc water drink intake rate vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. drinking behavior trait male 126 days 18 53.12 ml/d 30.74 130.42 metabolic cage water drinking measurement method 0.0 0 102127 2646
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc water drink intake rate vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. drinking behavior trait male 126 days 6 79.16 ml/d 16.78 41.1 metabolic cage water drinking measurement method 0.0 0 102130 2646
WF/Mol body weight vehicle control condition then artificial aortocaval fistula (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 8 202.0 g 3.0 8.49 body weighing method 0.0 acf 2 days 101312 2585
SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc urine potassium level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine potassium amount male 126 days 7 80.72 mmol/l 27.0 71.44 urine potassium analysis 0.0 0 102144 2646
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc urine creatinine level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine creatinine amount male 126 days 6 5.37 mg/dl 1.52 3.73 urine creatinine analysis 0.0 0 102155 2646
HanTac:WH ventral prostate gland wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. ventral prostate mass male 16 days-17 days 18 0.01 g 0.0 0.0 post excision weight measurement 0.0 0 96647 1559
Hsd:WI kidney glutathione level vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney glutathione amount male 0 days 6 7882.76 ug/g 178.16 436.39 liquid phase colorimetry 0.0 0 76239 1544
Crl:CD(SD) serum estradiol level maternal milk (for 20 days) and vehicle control condition (for 15 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. blood estradiol amount female 50 days 32 34.4 pg/ml 2.7 15.27 radioimmunoassay 0.0 0 76260 1558
Hsd:WI right kidney wet weight to body weight ratio vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. kidney mass male 119 days-126 days 5 3.14 mg/g 0.06 0.13 post excision weight measurement 0.0 0 76080 1545
HanTac:WH retroperitoneal fat pad weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. retroperitoneal fat pad mass female 16 days-17 days 15 0.03 g 0.0 0.01 post excision weight measurement 0.0 0 96712 1559
Hsd:WI body weight vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. body mass male 0 days 6 137.6 g 0.45 1.1 body weighing method 0.0 0 75952 1544
BluHsd:LE body weight vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. body mass male 98 days 8 457.7 g 15.9 44.97 body weighing method 0.0 0 75962 1543
BluHsd:LE body weight gain vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. body mass male 71 days-98 days 8 104.6 g 5.9 16.69 body weighing method 0.0 0 75969 1543
HanTac:WH retroperitoneal fat pad weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. retroperitoneal fat pad mass male 16 days-17 days 18 0.04 g 0.0 0.01 post excision weight measurement 0.0 0 96682 1559
SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc heart weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart mass male 126 days 0 4.26 g/kg 0.3 post excision weight measurement 0.0 0 102106 2646
SHRSP.WKY-(D3Mgh16-D3Rat80)/Gcrc heart left ventricle weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart left ventricle mass male 126 days 0 2.79 mg/g 0.14 post excision weight measurement 0.0 0 102113 2646
WKY/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 2.87 g/kg 0.23 post excision weight measurement 0.0 0 102119 2646
SHRSP.WKY-(D3Mgh16-D3Rat80)/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 3.77 g/kg 0.12 post excision weight measurement 0.0 0 102122 2646
GK/Slc blood hemoglobin A1c level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood hemoglobin amount male 105 days 0 5.21 % 0.12 blood hemoglobin analysis 0.0 0 HbA1c n=4-6 102880 2781
Slc:W urine acetoacetate level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. urine ketone body amount male 105 days 0 50.3 umol/l 2.6 urine analysis 0.0 0 n=4-6 102914 2781
GK/Slc urine 3-hydroxybutyrate level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. urine ketone body amount male 105 days 0 323.3 umol/l 92.7 urine analysis 0.0 0 n=4-6 102920 2781
SD body weight controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. body mass female 0 days 13 283.6 g 3.8 13.7 body weighing method 0.0 unx 97 days 100632 2499
LH/Mav blood glucose level vehicle control condition then fasting (for 16 hours) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood glucose amount male 56 days 11 69.0 mg/dl 1.0 3.32 blood glucose analysis 0.0 0 102716 2721
LH/Mav urine albumin level to urine total protein level ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 11 16.0 % 2.4 7.96 urine albumin analysis 0.0 0 102744 2721
LL/Mav plasma creatinine level vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood creatinine amount male 112 days 9 0.5 mg/dl 0.01 0.03 plasma creatinine analysis 0.0 0 102758 2721
WF/Mol systolic blood pressure vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. arterial blood pressure trait male 0 days 7 undefined 116.0 mmHg 4.0 10.58 tail cuff plethysmography 0.0 acf 7 days 101350 2585
WF/Mol systolic blood pressure vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. arterial blood pressure trait male 0 days 5 undefined 160.0 mmHg 4.0 8.94 tail cuff plethysmography 0.0 sham acf 4 days 101361 2585
SS.ZUC-Leprfa-/-/Slc heart ventricle septal wall thickness bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle wall thickness female 91 days 8 0.21 cm 0.0 0.01 echocardiography 0.0 ovariectomy 42 days 101709 2622
WKY/NCrl number of spontaneous locomotor movements per unit time vehicle control condition (between 1 and 28 days) and dark phase of controlled light/dark cycle Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. voluntary movement trait male 168 days 6 2.8 /min 0.3 0.73 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks number of spontaneous locomotor movements per unit time (CMO:0003644) 103582 2827
GK logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 -7.29 null 0.09 0.26 wire myography 0.0 0 103588 2827
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 97.56 % 1.02 2.7 wire myography 0.0 0 103598 2827
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 99.75 % 2.32 6.14 wire myography 0.0 0 103606 2827
WI neuron golgi apparatus area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 1.05 % 0.04 0.08 ex vivo electron microscopy with digital image analysis 0.0 0 ga/cyto 103650 2844
WI neuron rough endoplasmic reticulum area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 27.4 % 0.51 1.02 ex vivo electron microscopy with digital image analysis 0.0 0 rer/cyto 103653 2844
WKY/NCrl water intake drink rate to body weight ratio vehicle control condition (between 1 and 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. drinking behavior trait male 140 days-175 days 6 50.0 ml/d/kg 1.0 2.45 drink intake measuring method 0 103498 2827
GK water intake drink rate to body weight ratio vehicle control condition (between 1 and 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. drinking behavior trait male 140 days-175 days 6 99.0 ml/d/kg 13.0 31.84 drink intake measuring method 0 103500 2827
WKY/NCrl serum fructosamine level vehicle control condition (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood fructosamine amount male 175 days 6 153.0 umol/l 3.0 7.35 serum fructosamine analysis 0.0 0 103502 2827
WKY/NCrl blood glucose level vehicle control condition (for 28 days) then fasting (for 16 hours) then glucose (2 g/kg) (for 2 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood glucose amount male 168 days 6 125.0 mg/dl 3.0 7.35 oral glucose tolerance test 0.0 0 103518 2827
WF/Mol heart rate vehicle control condition then artificial aortocaval fistula (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 5 470.0 beats/min 12.0 26.83 tail cuff plethysmography 0.0 acf 2 days 101378 2585
WF/Mol heart right ventricle weight vehicle control condition then artificial aortocaval fistula (for 9 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 7 0.09 g 0.0 0.01 post excision weight measurement 0.0 acf 9 days 101419 2585
MW body weight unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. body mass male 0 days 7 260.0 g 6.0 15.87 body measuring method 0.0 unx 42 days 101146 2581
SHR/NCrlCrlj blood sodium level unilateral nephrectomy (for 42 days) then vehicle control condition (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood sodium amount male 126 days 5 140.0 mmol/l 1.0 2.24 automated serum sodium test 0.0 unx 42 days 101238 2583
SS-Nppbem2Mcwi-/- heart left ventricle end-diastolic posterior wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle posterior wall thickness male 168 days 7 1.89 mm 0.16 0.42 echocardiography 0.0 0 99776 2319
Crlj:WI mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 96.0 mmHg 8.0 21.17 vascular transducer tipped catheter 0.0 0 103020 2784
GK mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 123.0 mmHg 5.0 13.23 vascular transducer tipped catheter 0.0 0 103026 2784
GK heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 279.0 beats/min 17.0 44.98 vascular transducer tipped catheter 0.0 0 103054 2784
GK heart rate vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 168 days 6 323.0 beats/min 8.0 19.6 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks nighttime measurement 103568 2827
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc urine urea level to urine creatinine level ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 6 76.34 null 4.14 10.14 urine urea analysis 0.0 0 103795 2646
SS-Nppbem2Mcwi-/- body weight vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. body mass male 168 days 7 425.0 g 22.0 58.21 body weighing method 0.0 0 99758 2319
SS-Nppbem2Mcwi-/- body weight vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. body mass male 252 days 7 452.0 g 21.0 55.56 body weighing method 0.0 0 99760 2319
LL/Mav plasma total cholesterol level vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood cholesterol amount male 112 days 13 50.58 mg/dl 2.7 9.74 blood cholesterol analysis 0.0 0 102662 2703
LH/Mav plasma total cholesterol level vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood cholesterol amount male 112 days 8 66.41 mg/dl 5.41 15.29 blood cholesterol analysis 0.0 0 102663 2703
LL/Mav both kidneys wet weight to body weight ratio vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. kidney mass male 112 days 13 6.53 g/kg 0.04 0.14 post excision weight measurement 0.0 0 102692 2703
SS.ZUC-Leprfa-/-/Slc heart ventricle septal wall thickness vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricle wall thickness male 91 days 13 0.21 cm 0.0 0.01 echocardiography 0.0 0 101992 2644
LH/Mav systolic blood pressure vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. arterial blood pressure trait male 56 days 11 mean of 3 samples of undefined duration serial mean 134.0 mmHg 4.0 13.27 tail cuff plethysmography 0.0 0 102704 2721
LL/Mav blood glucose level vehicle control condition then fasting (for 16 hours) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood glucose amount male 56 days 9 70.0 mg/dl 1.0 3.0 blood glucose analysis 0.0 0 102714 2721
SS-Nppbem2Mcwi-/- mean arterial blood pressure vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. arterial blood pressure trait male 252 days 7 serial mean 162.0 mmHg 29.0 76.73 tail cuff plethysmography 0.0 0 99838 2319
WKY blood glucose level vehicle control condition (1 null) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. blood glucose amount male 156 days 10 160.56 mg/dl 8.64 27.32 radioimmunoassay 0.0 0 99101 2219
WKY single kidney wet weight to body weight ratio vehicle control condition (1 null) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. kidney mass male 156 days 10 3.41 g/kg 0.34 1.08 post excision weight measurement 0.0 0 99113 2219
WF/Mol heart rate vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 6 448.0 beats/min 10.0 24.49 tail cuff plethysmography 0.0 acf 4 days 101382 2585
SS/NEisSlc heart left ventricle fractional shortening controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. heart left ventricle end-diastolic diameter male 126 days 8 24.8 % 1.2 3.39 transthoracic echocardiography 0.0 0 102317 2684
WF/Mol heart right ventricle weight vehicle control condition then sham surgical control condition (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 6 0.05 g 0.0 0.0 post excision weight measurement 0.0 sham acf 2 days 101423 2585
WKY/NHsd skin chloride level to skin dry weight ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin chloride amount male 0 days 7 0.07 mmol/g 0.01 0.02 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin cl mmol/g 99137 2238
WKY/NHsd skin potassium level to skin water level ratio standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin potassium amount male 0 days 7 80.0 mmol/l 1.1 2.91 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin k/h2o 99155 2238
WKY/NHsd plasma creatinine level standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood creatinine amount male 0 days 7 0.31 mg/dl 0.01 0.03 plasma creatinine analysis 0.0 0 99171 2238
WKY/NHsd plasma cystatin C level controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood cystatin C amount male 0 days 7 3.5 mg/l 0.2 0.53 automated plasma protein analysis 0.0 0 99177 2238
SS-Nppbem2Mcwi-/- heart left ventricle fractional shortening vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-diastolic diameter male 168 days 7 44.3 % 2.8 7.41 echocardiography 0.0 0 99806 2319
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 4.2 g/kg 0.62 post excision weight measurement 0.0 0 102125 2646
SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc water drink intake rate vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. drinking behavior trait male 126 days 9 58.47 ml/d 9.43 28.29 metabolic cage water drinking measurement method 0.0 0 102128 2646
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc urine potassium level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine potassium amount male 126 days 6 28.25 mmol/l 8.59 21.04 urine potassium analysis 0.0 0 102145 2646
WKY/NHsd skin sodium level to skin dry weight ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin sodium amount male 0 days 7 0.14 REQUEST NEW VALUE 0.01 0.01 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin mmol/g 99133 2238
WKY/NHsd urine sodium excretion rate controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. urine sodium amount male 0 days 7 41.9 mEq/d 5.2 13.76 urine sodium analysis 0.0 0 99185 2238
WKY/NHsd mean arterial blood pressure controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. arterial blood pressure trait male 0 days 7 116.0 mmHg 1.0 2.65 intra-aortic radiotelemetry 0.0 0 99189 2238
WF/Mol body weight gain vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 5 18.0 g 1.0 2.24 body weighing method 0.0 4 days change from surgery weight 101325 2585
WF/Mol body weight gain vehicle control condition then artificial aortocaval fistula (for 9 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 7 29.0 g 3.0 7.94 body weighing method 0.0 acf 9 days change from surgery weight 101331 2585
SS-Nppbem2Mcwi-/- heart left ventricle end-systolic posterior wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle posterior wall thickness male 252 days 7 3.41 mm 0.5 1.32 echocardiography 0.0 0 99796 2319
SS-Nppbem2Mcwi-/- ejection fraction vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. cardiac output trait male 84 days 7 83.3 % 4.3 11.38 echocardiography 0.0 0 99798 2319
SS.ZUC-Leprfa+/+/Slc body weight bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. body mass female 91 days 9 294.0 g 6.0 18.0 body weighing method 0.0 ovariectomy 42 days 101661 2622
SS.ZUC-Leprfa-/-/Slc body weight bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. body mass female 91 days 8 393.0 g 6.0 16.97 body weighing method 0.0 ovariectomy 42 days 101663 2622
SS.ZUC-Leprfa-/-/Slc tibia straight segment length bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. tibia length female 91 days 8 32.5 mm 0.9 2.55 body length measuring method 0.0 ovariectomy 42 days 101667 2622
SS.ZUC-Leprfa-/-/Slc heart rate bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 8 339.0 beats/min 11.0 31.11 tail cuff plethysmography 0.0 ovariectomy 42 days 101675 2622
SS.ZUC-Leprfa+/+/Slc heart weight to tibia length ratio bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart mass female 91 days 9 0.26 g/cm 0.01 0.02 post excision weight measurement 0.0 ovariectomy 42 days 101681 2622
SS.ZUC-Leprfa+/+/Slc heart left ventricle end-diastolic diameter bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle end-diastolic diameter female 91 days 9 7.21 mm 0.21 0.63 echocardiography 0.0 ovariectomy 42 days 101715 2622
SS.ZUC-Leprfa+/+/Slc myocardial performance index bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 9 0.44 null 0.01 0.03 echocardiography 0.0 ovariectomy 42 days 101739 2622
SS.ZUC-Leprfa-/-/Slc myocardial performance index bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 8 0.61 null 0.03 0.08 echocardiography 0.0 ovariectomy 42 days 101741 2622
SS.ZUC-Leprfa-/-/Slc heart left ventricular end-diastolic blood pressure to heart left ventricular end-diastolic diameter ratio bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricular blood pressure trait female 91 days 8 0.63 mmHg/mm 0.05 0.14 echocardiography 0.0 ovariectomy 42 days 101753 2622
MWF/ZtmRrrc body weight vehicle control condition Remuzzi A, et al., J Clin Invest. 1990 Feb;85(2):541-9. body mass male 126 days 7 385.0 g 11.34 30.0 body weighing method 0.0 0 100903 2541
WF/Mol body weight vehicle control condition then artificial aortocaval fistula (for 9 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 7 180.0 g 2.0 5.29 body weighing method 0.0 acf 9 days 101309 2585
WKY body weight unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 8 215.0 g 10.0 28.28 body weighing method 0.0 unx 28 days 99936 2378
SS.ZUC-Leprfa-/-/Slc serum insulin level vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood insulin amount male 91 days 6 0.0 mg/dl 0.0 0.0 serum insulin analysis 0.0 0 101959 2644
SS.ZUC-Leprfa-/-/Slc heart posterior wall thickness vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricle posterior wall thickness male 91 days 13 0.21 cm 0.01 0.02 echocardiography 0.0 0 101998 2644
SS.ZUC-Leprfa-/-/Slc heart left ventricle relative wall thickness vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricle wall thickness male 91 days 13 49.0 % 1.0 3.61 echocardiography 0.0 0 102004 2644
SS-Sod3m1Mcwi lung weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56 days 10 1.2 g 0.01 0.03 post excision weight measurement 0.0 0 106559 3032
SS/JrHsdMcwi kidney weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. kidney mass male 56 days 7 2.13 g 0.05 0.13 post excision weight measurement 0.0 0 106578 3032
SS-Sod3m1Mcwi heart right ventricle weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56 days 10 0.61 mg/g 0.01 0.03 post excision weight measurement 0.0 0 106583 3032
SS-Sod3m1Mcwi lung weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56 days 10 0.47 % 0.01 0.02 post excision weight measurement 0.0 0 106591 3032
SD-Ahrem2Sage spleen weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. spleen mass female 84 days 10 0.29 % 0.02 0.07 post excision weight measurement 0 105897 3021
SS-Sod3m1Mcwi heart left ventricle weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left ventricle mass male 56 days 10 0.18 g/cm 0.0 0.01 post excision weight measurement 0.0 0 106615 3032
SS/JrHsdMcwi lung weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56 days 7 0.29 g/cm 0.05 0.12 post excision weight measurement 0.0 0 106618 3032
SD retinal uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 35 days-49 days 3 212.0 % 13.0 22.52 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106114 3028
SD retinal uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 35 days-49 days 3 24.0 % 5.8 10.05 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106117 3028
SD-Abcb1aem1Sage-/- retinal uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina molecular composition trait male 42 days-56 days 3 88.0 % 29.7 51.44 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106126 3028
SD brain uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. brain molecular composition trait male 35 days-49 days 3 9.07 % 0.89 1.54 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106156 3028
Hsd:SD mean corpuscular volume vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte size trait female 84 days 10 57.96 fl 1.26 3.98 automated hematology analysis 0 105968 3021
Hsd:SD platelet count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. platelet quantity female 84 days 10 1308.4 x 1000 /ul 220.08 695.95 automated hematology analysis 0 106004 3021
SD-Ahrem2Sage platelet count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. platelet quantity female 84 days 10 1388.0 x 1000 /ul 216.06 683.24 automated hematology analysis 0 106005 3021
SD intestine trypsin level vehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days) Zhuang ZM, et al., Int J Clin Exp Med. 2015 May 15;8(5):6866-77. eCollection 2015. intestine trypsin amount not specified 0 days 4 0.17 ug/l 0.01 0.01 enzyme linked immunosorbent assay 0.0 0 error not defined 105419 3015
Crl:WI timed urine volume vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. urine output male 114 days 10 11.1 ml/d 1.3 4.11 metabolic cage urine volume measurement method 0.0 0 109399 3140
Crl:WI urine albumin excretion rate vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. urine albumin amount male 114 days 10 0.17 mg/d 0.01 0.03 enzyme linked immunosorbent assay 0.0 0 109403 3140
MWF/FubRkb systolic blood pressure vehicle control condition (10 mg/kg/d) (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. arterial blood pressure trait male 112 days 10 151.5 mmHg 9.0 28.46 tail cuff plethysmography 0.0 0 109409 3140
Crl:WI heart rate vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. heart pumping trait male 112 days 10 355.3 beats/min 9.7 30.67 tail cuff plethysmography heart 0.0 0 109411 3140
Crl:WI mesenteric artery wall thickness vehicle control condition Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. mesenteric artery morphology trait male 114 days 10 37.8 um 1.5 4.74 confocal microscopy 0.0 0 109419 3140
Crl:WI mesenteric artery adventitial thickness vehicle control condition Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. mesenteric artery morphology trait male 114 days 10 8.2 um 0.7 2.21 confocal microscopy 0.0 0 109423 3140
Crl:WI mesenteric artery media thickness vehicle control condition Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. mesenteric artery morphology trait male 114 days 10 18.5 um 0.8 2.53 confocal microscopy 0.0 0 109427 3140
MWF/FubRkb norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasoconstriction trait male 114 days 10 77.8 % 10.2 32.26 wire myography 0.0 0 109441 3140
SS/JrHsdMcwi liver weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56 days 7 29.2 mg/mm 1.28 3.39 post excision weight measurement 0.0 0 106630 3032
SS-Sod3m1Mcwi single kidney weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. kidney mass male 56 days 10 0.06 g/cm 0.0 0.0 post excision weight measurement 0.0 0 106635 3032
SS/JrHsdMcwi systolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56 days 6 115.0 mmHg 4.76 11.66 vascular fluid filled catheter 0.0 0 106802 3032
SS-Sod3m1Mcwi diastolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56 days 8 84.2 mmHg 4.96 14.03 vascular fluid filled catheter 0.0 0 106807 3032
Crl:CD(SD) full retina thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 137 days-144 days 5 191.6 um 7.56 16.9 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 full retina layer 105458 3016
Hsd:SD blood neutrophil count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. neutrophil quantity female 84 days 10 1.48 x 1000 cells/ul 0.85 2.69 automated hematology analysis 0 106028 3021
SD-Ahrem2Sage blood lymphocyte count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. lymphocyte quantity female 84 days 10 8.25 x 1000 cells/ul 1.31 4.14 automated hematology analysis 0 106041 3021
SD-Ahrem2Sage liver weight as percentage of body weight vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. liver mass female 84 days 10 3.43 % 0.3 0.95 post excision weight measurement 0.0 0 105726 3021
BDIX/CrCrl serum alkaline phosphatase activity level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood alkaline phosphatase amount male 92 days 10 620.0 U/l 7.27 23.0 automated serum analysis 0.0 0 serum alkaline phosphatase 107914 3097
SS/NEisSlc neuron count vehicle control condition (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. hippocampus neuron quantity not specified 547 days 10 1258.0 cells/mm2 32.0 101.19 ex vivo light microscopy with histochemistry 0.0 0 107465 2339
SHRSP/A3N urine total protein excretion rate controlled sodium chloride content drinking water (1 %) (between 35 and 49 days) and controlled fat content diet (24.5 %) (between 35 and 49 days) and vehicle control condition (between 35 and 49 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. total urine protein amount male 119 days-154 days 0 127.0 mg/d 13.0 urine protein analysis 86400.0 0 107520 3090
SHRSP/A3N kidney weight controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney mass male 126 days-182 days 0 2.65 g 0.1 post excision weight measurement kidney 0.0 0 107531 3090
SHRSP/A3N kidney glomerular lesion count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney glomerulus integrity trait male 126 days-182 days 0 76.5 /section 7.0 ex vivo light microscopy with histochemistry renal glomerulus 0.0 0 107539 3090
WAG/Nov thymocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymocyte quantity male 150 days-180 days 10 1028.62 x10E6/organ 146.62 463.65 isolated cell counting method 0.0 IP injection 1 days 107693 3096
RCS-p+/LavRrrc photopic B wave amplitude of ERG waveform vehicle control condition (2 ul) then visible light stimulus (25 cd x s/m2) Baranov P, et al., J Ocul Pharmacol Ther. 2017 Jun;33(5):412-422. doi: 10.1089/jop.2016.0121. Epub 2017 Apr 25. cone electrophysiology trait not specified 119 days 7 23.1 uV 1.0 2.65 electroretinography cornea 0.0 intravitrial injection 98 days 109739 3154
WAG/Nov G2/M stage tetraploid thymocyte count to total thymocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. T cell development trait male 150 days-180 days 10 2.62 % 0.29 0.92 flow cytometry method 0.0 IP injeciton 1 days saline 107712 3096
WAG/Nov CD4+CD8+ thymocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymocyte quantity male 150 days-180 days 10 596.53 x10E6/organ 88.59 280.15 flow cytometry method 0.0 IP injeciton 1 days saline cd4+cd8+ t-cell 107721 3096
ISIAH CD45RA+ splenocyte count to total splenocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 34.86 % 1.36 4.3 flow cytometry method 0.0 IP injeciton 1 days saline cd45 RA+ spleen 107745 3096
ISIAH plasma triglyceride level vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. blood triglyceride amount male 150 days-180 days 10