Phenominer Database Results (969 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
Hsd:WI serum total protein level vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. blood total protein amount male 119 days-126 days 5 9.38 g/dl 0.67 1.5 liquid phase colorimetry 0.0 0 76125 1545
BluHsd:LE food calorie intake level to change in body weight ratio controlled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. eating behavior trait male 71 days-98 days 8 10.1 kcal/g 0.3 0.85 unspecified method 0.0 0 76204 1543
Hsd:WI serum triglyceride level vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. blood triglyceride amount male 119 days-126 days 5 156.94 mg/dl 14.93 33.39 liquid phase colorimetry 0.0 0 76135 1545
Hsd:WI serum urea nitrogen level vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. blood urea nitrogen amount male 119 days-126 days 5 77.76 mg/dl 3.18 7.11 liquid phase colorimetry 0.0 0 76164 1545
Hsd:WI left kidney wet weight to body weight ratio vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. kidney mass male 119 days-126 days 5 3.07 mg/g 0.07 0.16 post excision weight measurement 0.0 0 76085 1545
Hsd:WI kidney superoxide dismutase activity to total protein level ratio vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney superoxide dismutase activity male 0 days 6 8.13 U/mg 0.79 1.94 liquid phase colorimetry 0.0 0 76188 1544
WKY/Izm absolute change in mean arterial blood pressure vehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 27.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 84566 1120
F344/NHsd serum alanine aminotransferase activity level fasting (between 12 and 15 hours) then vehicle control condition (for 1 days) McGill MR, et al., Toxicol Appl Pharmacol. 2012 Nov 1;264(3):387-94. doi: 10.1016/j.taap.2012.08.015. Epub 2012 Aug 23. blood alanine transaminase amount not specified 56 days-84 days 4 35.0 U/l 11.0 22.0 spectrophotometry 0.0 0 84754 1601
Hsd:WI change in body weight to body weight ratio vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. body mass male 119 days-126 days 5 255.0 % 13.42 30.0 body weighing method 0.0 0 76065 1545
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure air-jet exposure (for 0 hours) then vehicle control condition (2 ul) (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 -1.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84555 1120
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in heart rate air-jet exposure (for 0 hours) then vehicle control condition (2 ul) (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. heart pumping trait male 98 days 6 -5.0 beats/min 7.0 17.15 vascular indwelling catheter method 0.0 0 84564 1120
HanTac:WH both seminal vesicles wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. seminal gland mass male 16 days-17 days 18 7.1 mg 0.47 2.0 post excision weight measurement 0.0 0 96657 1559
HanTac:WH left ovary wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. ovary mass female 16 days-17 days 15 3.2 mg 0.27 1.04 post excision weight measurement 0.0 0 left ovary 96697 1559
SHRSP.WKY-(D3Mgh16-D3Rat80)/Gcrc heart weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart mass male 126 days 0 3.88 g/kg 0.12 post excision weight measurement 0.0 0 102104 2646
SHRSP/Gcrc heart left ventricle weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart left ventricle mass male 126 days 0 3.64 mg/g 0.39 post excision weight measurement 0.0 0 102109 2646
SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc heart left ventricle weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart left ventricle mass male 126 days 0 3.04 mg/g 0.29 post excision weight measurement 0.0 0 102111 2646
SS/NEisSlc creatinine clearance controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. glomerular filtration trait male 126 days 8 1.9 ml/min 0.5 1.41 serum creatinine analysis 0.0 0 102332 2684
SS/NEisSlc timed urine volume controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. urine output male 126 days 8 53.6 ml/d 7.1 20.08 urine volume measurement method 0.0 0 102335 2684
SS/NEisSlc urine total protein excretion rate controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. total urine protein amount male 126 days 8 307.0 mg/d 46.0 130.11 urine protein analysis 0.0 0 102338 2684
WKY/NCrl serum fructosamine level vehicle control condition (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood fructosamine amount male 175 days 6 153.0 umol/l 3.0 7.35 serum fructosamine analysis 0.0 0 103502 2827
GK systolic blood pressure vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 145.0 mmHg 4.0 9.8 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103528 2827
WF/Mol body weight gain vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 6 8.0 g 2.0 4.9 body weighing method 0.0 acf 7 days change from surgery weight 101342 2585
WF/Mol body weight gain vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 5 23.0 g 3.0 6.71 body weighing method 0.0 sham acf 7 days change from surgery weight 101343 2585
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 17 0.5 ml/min/100g 0.03 0.12 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99981 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 17 16.7 mmHg/ml/min 1.4 5.77 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99996 2378
Crl:CD(SD) serum creatinine level control condition (for 28 days) then vehicle control condition (for 84 days) Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. blood creatinine amount male 112 days 5 0.43 mg/dl 0.03 0.07 serum creatinine analysis 0.0 0 100766 2521
WKY heart left ventricle infarction size to total heart left ventricle size ratio left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle integrity trait male 238 days-252 days 30 35.8 % 5.4 29.58 ex vivo microscopy with digital image analysis 0.0 lad occlusion 196 days 100264 2460
WKY heart left ventricle weight left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle mass male 238 days-252 days 30 0.97 g 0.08 0.43 post excision weight measurement 0.0 lad occlusion 196 days 100290 2460
SD serum creatinine level controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. blood creatinine amount female 0 days 13 1.65 mg/dl 0.14 0.5 serum creatinine analysis 0.0 unx 97 days 100637 2499
SD serum parathyroid hormone level controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. blood parathyroid hormone amount female 0 days 13 3496.0 pg/ml 862.0 3107.99 serum parathyroid hormone analysis 0.0 unx 97 days 100647 2499
GK mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 5 undefined 118.0 mmHg 7.0 15.65 vascular transducer tipped catheter 0.0 0 103025 2784
LL/Mav body weight vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. body mass male 112 days 9 364.0 g 6.0 18.0 body weighing method 0.0 0 102722 2721
LH/Mav body weight vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. body mass male 112 days 11 384.0 g 9.0 29.85 body weighing method 0.0 0 102724 2721
LL/Mav timed urine volume vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine output male 112 days 9 12.4 ml/d 0.6 1.8 urine volume measurement method 0.0 0 102730 2721
LL/Mav urine total protein excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. total urine protein amount male 112 days 9 37.0 mg/d 1.0 3.0 urine protein analysis 0.0 0 102734 2721
LH/Mav plasma total cholesterol level vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood cholesterol amount male 112 days 11 90.35 mg/dl 7.34 24.33 plasma total cholesterol measurement test 0.0 0 102752 2721
LL/Mav aorta weight to body weight ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. aorta mass male 112 days 9 11.2 mg/100g 0.2 0.6 post excision weight measurement 0.0 0 102770 2721
LH/Mav aorta weight to body weight ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. aorta mass male 112 days 11 13.5 mg/100g 0.2 0.66 post excision weight measurement 0.0 0 102772 2721
GK/Slc blood urea nitrogen level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood urea nitrogen amount male 105 days 0 15.7 mg/dl 1.2 blood urea nitrogen analysis 0.0 0 n=4-6 102904 2781
Slc:W urine 3-hydroxybutyrate level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. urine ketone body amount male 105 days 0 265.3 umol/l 11.7 urine analysis 0.0 0 n=4-6 102918 2781
GK/Slc timed urine volume vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. urine output male 105 days 0 9.6 ml/d 0.7 urine volume measurement method 0.0 0 n=4-6 102924 2781
WF/Mol heart left ventricle weight vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart left ventricle mass male 0 days 5 0.21 g 0.01 0.01 post excision weight measurement 0.0 sham acf 7 days 101395 2585
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 97.56 % 1.02 2.7 wire myography 0.0 0 103598 2827
GK logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 -7.39 null 0.04 0.11 wire myography 0.0 0 103604 2827
GK sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 86.87 % 3.06 8.65 wire myography 0.0 0 103616 2827
OXYS/Nov neuron mitochondrion area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 3.6 % 0.1 0.2 ex vivo electron microscopy with digital image analysis 0.0 0 mito/cyto 103645 2844
WKY/NCrl diastolic blood pressure vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 85.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103542 2827
WKY/NCrl heart rate vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 168 days 6 344.0 beats/min 5.0 12.25 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks nighttime measurement 103566 2827
MW mean arterial blood pressure unilateral nephrectomy (for 70 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 7 undefined 108.0 mmHg 2.0 5.29 vascular indwelling catheter method 0.0 unx 70 days 101173 2581
SHR/NCrlCrlj blood sodium level unilateral nephrectomy (for 42 days) then vehicle control condition (for 28 days) Kohara K, et al., Hypertension. 1993 Jun;21(6 Pt 2):975-9. blood sodium amount male 126 days 5 140.0 mmol/l 1.0 2.24 automated serum sodium test 0.0 unx 42 days 101238 2583
SS-Nppbem2Mcwi-/- heart left ventricle end-systolic diameter vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-systolic diameter male 84 days 7 3.98 mm 0.45 1.19 echocardiography 0.0 0 99786 2319
SS-Nppbem2Mcwi-/- heart left ventricle end-systolic diameter vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-systolic diameter male 252 days 7 4.67 mm 0.74 1.96 echocardiography 0.0 0 99790 2319
Crlj:WI mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 6 undefined 99.0 mmHg 7.0 17.15 vascular transducer tipped catheter 0.0 0 103023 2784
Crlj:WI heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 380.0 beats/min 18.0 47.62 vascular transducer tipped catheter 0.0 0 103040 2784
WF/Mol systolic blood pressure vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. arterial blood pressure trait male 0 days 5 undefined 165.0 mmHg 7.0 15.65 tail cuff plethysmography 0.0 sham acf 7 days 101365 2585
WF/Mol heart left ventricle weight vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart left ventricle mass male 0 days 8 0.28 g 0.01 0.03 post excision weight measurement 0.0 acf 7 days 101408 2585
LL/Mav blood glucose level vehicle control condition then fasting (for 16 hours) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood glucose amount male 49 days-56 days 13 65.0 mg/dl 1.0 3.61 blood glucose analysis 0.0 0 102656 2703
LH/Mav blood glucose level vehicle control condition then fasting (for 16 hours) then glucose (2 g/kg) (for 1 hours) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood glucose amount male 49 days-56 days 8 121.0 mg/dl 6.0 16.97 blood glucose analysis 0.0 0 102660 2703
LL/Mav plasma creatinine level vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood creatinine amount male 112 days 13 0.52 mg/dl 0.01 0.04 plasma creatinine analysis 0.0 0 102674 2703
LL/Mav heart left ventricle weight to body weight ratio vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. heart left ventricle mass male 112 days 13 20.4 mg/g 0.1 0.36 post excision weight measurement 0.0 0 102680 2703
LL/Mav systolic blood pressure vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. arterial blood pressure trait male 56 days 9 mean of 3 samples of undefined duration serial mean 115.0 mmHg 5.0 15.0 tail cuff plethysmography 0.0 0 102702 2721
LH/Mav systolic blood pressure vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. arterial blood pressure trait male 56 days 11 mean of 3 samples of undefined duration serial mean 134.0 mmHg 4.0 13.27 tail cuff plethysmography 0.0 0 102704 2721
WF/Mol heart rate vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 6 448.0 beats/min 7.0 17.15 tail cuff plethysmography 0.0 acf 7 days 101387 2585
WKY single kidney wet weight to body weight ratio vehicle control condition (1 null) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. kidney mass male 156 days 10 3.41 g/kg 0.34 1.08 post excision weight measurement 0.0 0 99113 2219
WKY timed urine volume vehicle control condition (1 null) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. urine output male 156 days 10 17.1 ml/d 1.57 4.96 urine volume measurement method 0.0 0 99119 2219
WF/Mol heart right ventricle weight vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 5 0.05 g 0.0 0.0 post excision weight measurement 0.0 sham acf 4 days 101427 2585
LH/Mav systolic blood pressure vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. arterial blood pressure trait male 49 days-56 days 8 undefined 136.0 mmHg 3.0 8.49 tail cuff plethysmography 0.0 0 102645 2703
LL/Mav urine total protein excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. total urine protein amount male 56 days 9 26.0 mg/d 1.0 3.0 urine protein analysis 0.0 0 102710 2721
LH/Mav urine total protein excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. total urine protein amount male 56 days 11 70.0 mg/d 9.0 29.85 urine protein analysis 0.0 0 102712 2721
SS-Nppbem2Mcwi-/- diastolic blood pressure vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. arterial blood pressure trait male 168 days 7 serial mean 142.0 mmHg 28.0 74.08 tail cuff plethysmography 0.0 0 99824 2319
SS-Nppbem2Mcwi-/- mean arterial blood pressure vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. arterial blood pressure trait male 252 days 7 serial mean 162.0 mmHg 29.0 76.73 tail cuff plethysmography 0.0 0 99838 2319
WF/Mol heart rate vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 6 448.0 beats/min 10.0 24.49 tail cuff plethysmography 0.0 acf 4 days 101382 2585
SS/NEisSlc body weight controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. body mass male 126 days 8 361.0 g 9.0 25.46 body weighing method 0.0 0 102311 2684
WKY timed urine volume left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. urine output male 238 days-252 days 7 10.6 ml/d 2.2 5.82 urine volume measurement method 0.0 lad occlusion 196 days 100376 2460
SS-Nppbem2Mcwi-/- heart left ventricle end-systolic posterior wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle posterior wall thickness male 252 days 7 3.41 mm 0.5 1.32 echocardiography 0.0 0 99796 2319
SS-Nppbem2Mcwi-/- ejection fraction vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. cardiac output trait male 168 days 7 80.2 % 3.4 9.0 echocardiography 0.0 0 99800 2319
SS.ZUC-Leprfa+/+/Slc body weight bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. body mass female 91 days 9 294.0 g 6.0 18.0 body weighing method 0.0 ovariectomy 42 days 101661 2622
SS.ZUC-Leprfa-/-/Slc systolic blood pressure bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. arterial blood pressure trait female 91 days 8 undefined 221.0 mmHg 5.0 14.14 tail cuff plethysmography 0.0 ovariectomy 42 days 101671 2622
SS.ZUC-Leprfa-/-/Slc heart left ventricle posterior wall thickness bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle posterior wall thickness female 91 days 8 2.06 mm 0.04 0.11 echocardiography 0.0 ovariectomy 42 days 101713 2622
SS.ZUC-Leprfa+/+/Slc heart left ventricle fractional shortening bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle end-diastolic diameter female 91 days 9 39.8 % 2.5 7.5 echocardiography 0.0 ovariectomy 42 days 101719 2622
SS.ZUC-Leprfa-/-/Slc heart left ventricle fractional shortening bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle end-diastolic diameter female 91 days 8 47.7 % 1.9 5.37 echocardiography 0.0 ovariectomy 42 days 101721 2622
SS.ZUC-Leprfa-/-/Slc E wave deceleration time bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 8 56.9 ms 1.8 5.09 echocardiography 0.0 ovariectomy 42 days 101733 2622
SS.ZUC-Leprfa+/+/Slc heart isovolumetric relaxation time bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart muscle relaxation trait female 91 days 9 24.8 ms 1.8 5.4 echocardiography 0.0 ovariectomy 42 days 101735 2622
SS.ZUC-Leprfa+/+/Slc left ventricular end-diastolic blood pressure bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricular blood pressure trait female 91 days 9 2.27 mmHg 0.11 0.33 vascular transducer tipped catheter 0.0 ovariectomy 42 days 101743 2622
SD-Nfe2l2em1Mcwi-/- middle cerebral artery inner diameter controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) then physiological salt solution perfusate Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. cerebral artery size trait male 9 days-11 days 4 154.0 um 15.0 30.0 ex vivo method 0.0 0 resting diameter 100752 2520
SS.ZUC-Leprfa-/-/Slc heart weight to tibia length ratio bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart mass female 91 days 8 0.35 g/cm 0.0 0.0 post excision weight measurement 0.0 ovariectomy 42 days 101693 2622
SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc water drink intake rate vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. drinking behavior trait male 126 days 9 58.47 ml/d 9.43 28.29 metabolic cage water drinking measurement method 0.0 0 102128 2646
SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc water drink intake rate vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. drinking behavior trait male 126 days 7 57.55 ml/d 15.23 40.29 metabolic cage water drinking measurement method 0.0 0 102129 2646
SHRSP/Gcrc timed urine volume vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine output male 126 days 17 55.29 ml/d 15.78 65.06 metabolic cage urine volume measurement method 0.0 0 102131 2646
WKY/NHsd skin chloride level to skin water level ratio standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin chloride amount male 0 days 7 42.0 mmol/l 2.4 6.35 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin cl/h2o 99151 2238
WKY/NHsd skin chloride level to skin water level ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin chloride amount male 0 days 7 48.0 mmol/l 4.8 12.7 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin cl/h2o 99153 2238
WKY/NHsd plasma creatinine level standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood creatinine amount male 0 days 7 0.31 mg/dl 0.01 0.03 plasma creatinine analysis 0.0 0 99171 2238
SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc timed urine volume vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine output male 126 days 9 34.03 ml/d 7.02 21.06 metabolic cage urine volume measurement method 0.0 0 102133 2646
SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc urine creatinine level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine creatinine amount male 126 days 9 10.42 mg/dl 1.8 5.41 urine creatinine analysis 0.0 0 102153 2646
WF/Mol body weight vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 7 184.0 g 3.0 7.94 body weighing method 0.0 acf 7 days 101306 2585
WF/Mol body weight vehicle control condition then artificial aortocaval fistula (for 9 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 7 180.0 g 2.0 5.29 body weighing method 0.0 acf 9 days 101309 2585
WKY heart posterior wall thickness left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle posterior wall thickness male 238 days-252 days 30 0.18 cm 0.0 0.02 echocardiography 0.0 lad occlusion 196 days 100347 2460
SD-Nfe2l2em1Mcwi-/- body weight controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. body mass male 9 days-11 days 4 299.0 g 22.2 44.4 body weighing method 0.0 0 100734 2520
SS.ZUC-Leprfa-/-/Slc serum low density lipoprotein cholesterol level vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood LDL cholesterol amount male 91 days 6 102.5 mg/dl 9.37 22.95 serum low-density lipoprotein-cholesterol measurement test 0.0 0 101944 2644
SS.ZUC-Leprfa-/-/Slc serum glucose level vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood glucose amount male 91 days 6 149.4 mg/dl 12.36 30.28 serum glucose analysis 0.0 0 101956 2644
SS.ZUC-Leprfa-/-/Slc serum insulin level vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood insulin amount male 91 days 6 0.0 mg/dl 0.0 0.0 serum insulin analysis 0.0 0 101959 2644
SS.ZUC-Leprfa-/-/Slc ejection fraction vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. cardiac output trait male 91 days 13 82.5 % 1.94 6.99 echocardiography 0.0 0 102010 2644
SS.ZUC-Leprfa-/-/Slc left ventricular end-diastolic blood pressure vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricular blood pressure trait male 91 days 13 17.65 mmHg 1.43 5.16 vascular transducer tipped catheter 0.0 0 102022 2644
Hsd:SD spleen weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. spleen mass female 84 days 10 0.3 % 0.03 0.09 post excision weight measurement 0 105896 3021
SD-Ahrem2Sage brain weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. brain mass female 84 days 10 0.74 % 0.04 0.14 post excision weight measurement 0 105909 3021
Hsd:SD both ovaries weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. ovary mass female 84 days 10 0.05 % 0.01 0.03 post excision weight measurement 0 105920 3021
SS-Sod3m1Mcwi heart right ventricle weight to left ventricle plus septum weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56 days 10 0.25 g/g 0.01 0.03 post excision weight measurement 0.0 0 heart right ventricle weight to left ventricle plus septum weight ratio 106537 3032
SS/JrHsdMcwi heart right ventricle weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56 days 7 0.16 g 0.01 0.02 post excision weight measurement 0.0 0 106540 3032
SS/JrHsdMcwi heart right atrium weight to left atrium weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56 days 7 1.09 null 0.09 0.24 post excision weight measurement 0.0 0 106570 3032
SS-Sod3m1Mcwi lung weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56 days 10 0.47 % 0.01 0.02 post excision weight measurement 0.0 0 106591 3032
SS-Sod3m1Mcwi heart left atrium weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left atrium mass male 56 days 10 0.06 mg/g 0.01 0.03 post excision weight measurement 0.0 0 106599 3032
SS/JrHsdMcwi single kidney wet weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. kidney mass male 56 days 7 8.14 g/kg 0.11 0.29 post excision weight measurement 0.0 0 106606 3032
SS/JrHsdMcwi lung weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56 days 7 0.29 g/cm 0.05 0.12 post excision weight measurement 0.0 0 106618 3032
SS-Sod3m1Mcwi lung weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56 days 10 0.33 g/cm 0.0 0.01 post excision weight measurement 0.0 0 106619 3032
SD-Abcb1aem1Sage-/- retinal uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina blood vessel morphology trait male 42 days-56 days 3 536.0 % 6.0 10.39 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106129 3028
SS-Sod3m1Mcwi right ventricular end-systolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricular blood pressure trait male 56 days 15 25.1 mmHg 0.53 2.05 vascular fluid filled catheter 0.0 0 106797 3032
Hsd:SD white blood cell count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. leukocyte quantity female 84 days 10 9.42 x 1000 cells/ul 2.25 7.12 automated hematology analysis 0 106016 3021
Hsd:SD blood neutrophil count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. neutrophil quantity female 84 days 10 1.48 x 1000 cells/ul 0.85 2.69 automated hematology analysis 0 106028 3021
SD-Ahrem2Sage blood lymphocyte count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. lymphocyte quantity female 84 days 10 8.25 x 1000 cells/ul 1.31 4.14 automated hematology analysis 0 106041 3021
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 26 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 80 days-87 days 10 126.0 um 4.02 9.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography inner retinal layer 105486 3016
Crl:CD(SD) retinal outer layer thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136 days-143 days 5 129.8 um 4.02 9.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography outer retinal layer 105498 3016
SS-Sod3m1Mcwi heart left atrium weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left atrium mass male 56 days 10 0.45 mg/mm 0.03 0.09 post excision weight measurement 0.0 0 106627 3032
Hsd:SD red blood cell count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 7.47 x 10E6 cells/ul 0.21 0.66 automated hematology analysis 0 105932 3021
SD-Ahrem2Sage hematocrit vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 43.31 % 1.67 5.28 automated hematology analysis 0 105957 3021
Hsd:SD mean corpuscular hemoglobin vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 18.82 pg 0.44 1.39 automated hematology analysis 0 105980 3021
Hsd:SD platelet count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. platelet quantity female 84 days 10 1308.4 x 1000 cells/ul 220.08 695.95 automated hematology analysis 0 106004 3021
SD-Ahrem2Sage platelet count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. platelet quantity female 84 days 10 1388.0 x 1000 cells/ul 216.06 683.24 automated hematology analysis 0 106005 3021
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81 days-88 days 5 11.3 null 0.37 0.83 ex vivo light microscopy with histochemistry 0.0 0 nuclei per cell 105450 3016
SD-Ahrem2Sage liver weight as percentage of body weight vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. liver mass female 84 days 10 3.43 % 0.3 0.95 post excision weight measurement 0.0 0 105726 3021
SHRSP/A3NCrl body weight controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. body mass male 161 days-175 days 6 307.0 g 8.0 19.6 body weighing method 0.0 0 107382 3083
SHRSP/A3NCrl creatinine clearance controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. glomerular filtration trait male 161 days-175 days 6 2.0 ml/min 0.2 0.49 urine creatinine analysis 0.0 0 107388 3083
SS/NEisSlc timed urine volume to body weight ratio vehicle control condition (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. urine output not specified 547 days 10 0.02 ul/min/g 0.0 0.01 urine volume measurement method 0.0 0 107429 2339
ISIAH thymus weight to body weight ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymus mass male 150 days-180 days 10 1.95 mg/g 0.77 2.43 post excision weight measurement 0.0 IP injeciton 1 days saline 107689 3096
MWF/FubRkb systolic blood pressure vehicle control condition (10 mg/kg/d) (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. arterial blood pressure trait male 112 days 10 151.5 mmHg 9.0 28.46 tail cuff plethysmography 0.0 0 109409 3140
Crl:WI acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasodilation trait male 114 days 10 90.3 % 1.2 3.79 wire myography mesenteric artery 0.0 0 109431 3140
Crl:WI norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasoconstriction trait male 114 days 10 51.3 % 4.7 14.86 wire myography 0.0 0 109439 3140
Crl:WI negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasoconstriction trait male 114 days 10 6.7 null 0.1 0.32 wire myography 0.0 0 109443 3140
MWF/FubRkb negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasoconstriction trait male 114 days 10 6.9 null 0.1 0.32 wire myography 0.0 0 109445 3140
WAG/Nov CD3+ splenocyte count to total splenocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 30.13 % 0.75 2.37 flow cytometry method 0.0 IP injeciton 1 days saline cd3- spleen 107733 3096
ISIAH CD4+CD25+ splenocyte count to total splenocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 1.7 % 0.17 0.54 flow cytometry method 0.0 IP injeciton 1 days saline cd4+cd25+ spleen 107742 3096
ISIAH CD11b/c+ splenocyte count to total splenocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 8.4 % 1.11 3.51 flow cytometry method 0.0 IP injeciton 1 days saline cd11b/c+ spleen 107748 3096
ISIAH CD4+CD8+ thymocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymocyte quantity male 150 days-180 days 10 419.0 x10E6/organ 50.57 159.92 flow cytometry method 0.0 IP injeciton 1 days saline cd4+cd8+ t-cell 107766 3096
BDIX/CrCrl blood hemoglobin level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood hemoglobin amount male 92 days 10 18.9 g/dl 0.47 1.5 blood hemoglobin analysis 0.0 0 hemoglobin, MCH, MCHC 107833 3097
SHRSP/A3N urine total protein excretion rate controlled sodium chloride content drinking water (1 %) (between 35 and 49 days) and controlled fat content diet (24.5 %) (between 35 and 49 days) and vehicle control condition (between 35 and 49 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. total urine protein amount male 119 days-154 days 0 127.0 mg/d 13.0 urine protein analysis 86400.0 0 107520 3090
BDIX/CrCrl mean corpuscular volume DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. erythrocyte size trait male 71 days 10 47.5 fl 0.03 0.1 automated hematology analysis 0.0 0 MCV, RDW% 107806 3097
BDIX/CrCrl hematocrit DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. erythrocyte quantity male 92 days 10 51.0 % 1.04 3.3 hematocrit analysis 0.0 0 red blood cell count, hematocrit 107813 3097
WKY body weight unilateral nephrectomy (for 150 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 11 408.0 g 10.0 33.17 body weighing method 0.0 unx 150 days 107445 2378
BDIX/CrCrl serum amylase activity level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood amylase amount male 92 days 10 3190.0 U/l 77.16 244.0 automated serum analysis 0.0 0 serum amylase 107946 3097
BDIX/CrCrl blood granulocyte count to total leukocyte count ratio DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. granulocyte quantity male 92 days 10 0.8 % 0.0 0.0 automated differential white blood cell count test 0.0 0 107858 3097
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 17 13.2 x 10E3 um2 3.3 13.61 ex vivo light microscopy with histochemistry 0.0 unx 150 days 107511 2378
Crl:WI tibia length vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. tibia length male 113 days 10 4.0 cm 1.0 3.16 post excision length measurement 0.0 0 109395 3140
Hsd:WI kidney superoxide dismutase activity to total protein level ratio vehicle control condition (for 10 days) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney superoxide dismutase activity male 0 days 6 13.53 U/mg 0.8 1.97 liquid phase colorimetry 0.0 0 76187 1544
Hsd:WI spleen weight to body weight ratio vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. spleen mass male 119 days-126 days 5 0.18 % 0.01 0.02 post excision weight measurement 0.0 0 76120 1545
BluHsd:LE body weight vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. body mass male 70 days 8 345.8 g 13.1 37.05 body weighing method 0.0 0 76140 1543
Hsd:WI serum total cholesterol level vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. blood cholesterol amount male 119 days-126 days 5 68.12 mg/dl 6.42 14.36 liquid phase colorimetry 0.0 0 76130 1545
Crl:CD(SD) post-insult time to mammary tumor formation maternal milk (for 20 days) and vehicle control condition (for 15 days) then 7,12-dimethyltetraphene (DMBA) (30 mg/kg) (for 1 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. mammary gland integrity trait female 0 days-365 days 32 median 65.0 d manual palpation method 0.0 0 76267 1558
SD-Abcb1aem1Sage-/- brain uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. blood-brain barrier morphology trait male 42 days-56 days 3 14.0 % 7.3 12.64 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106162 3028
BluHsd:LE serum estradiol level vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. blood estradiol amount male 98 days 8 290.0 pg/ml 10.0 28.28 radioimmunoassay 0.0 0 tritium-based 76255 1543
SS/JrHsdMcwi heart right ventricle weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56 days 7 4.51 mg/mm 0.22 0.58 post excision weight measurement 0.0 0 106610 3032
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 11 0.52 ml/min/100g 0.01 0.04 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99980 2378
OXYS/Nov neuron vacuole area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 8.23 % 0.4 0.8 ex vivo electron microscopy with digital image analysis 0.0 0 v/cyto 103657 2844
MW systolic blood pressure unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 7 undefined 118.0 mmHg 2.0 5.29 tail cuff plethysmography 0.0 unx 14 days 101159 2581
MW blood urea nitrogen level unilateral nephrectomy (for 70 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. blood urea nitrogen amount male 0 days 7 26.0 mg/dl 1.0 2.65 blood urea nitrogen analysis 0.0 unx 70 days 101187 2581
SD mean arterial blood pressure artificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. arterial blood pressure trait male 0 days 6 72.0 mmHg 2.0 4.9 vascular transducer tipped catheter 1.0 ACF 2 days 98814 2160
LH/Mav plasma creatinine level vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood creatinine amount male 112 days 11 0.52 mg/dl 0.01 0.03 plasma creatinine analysis 0.0 0 102760 2721
WKY heart weight left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart mass male 238 days-252 days 30 1.57 g 0.28 1.53 post excision weight measurement 0.0 lad occlusion 196 days 100278 2460
SS-Nppbem2Mcwi-/- heart interventricular end-systolic septal wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart ventricle septum thickness male 168 days 7 3.24 mm 0.21 0.56 echocardiography 0.0 0 99782 2319
Crlj:WI heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 415.0 beats/min 10.0 26.46 vascular transducer tipped catheter 0.0 0 103036 2784
SHRSP/Gcrc urine urea level to urine creatinine level ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 17 112.69 null 29.95 123.49 urine urea analysis 0.0 0 103791 2646
SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc urine urea level to urine creatinine level ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 7 101.15 null 8.47 22.41 urine urea analysis 0.0 0 103794 2646
WF/Mol heart right ventricle weight vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 6 0.05 g 0.0 0.0 post excision weight measurement 0.0 sham acf 7 days 101431 2585
WF/Mol heart rate vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 5 366.0 beats/min 12.0 26.83 tail cuff plethysmography 0.0 sham acf 4 days 101383 2585
HanTac:WH number of blastocysts/embryos lost postimplantation to litter size ratio vehicle control condition (for 14 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. embryonic growth trait female 0 days 18 7.9 % 2.71 11.5 unspecified method 0.0 0 96588 1559
LH/MavRrrc aorta weight to body weight ratio vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. aorta mass male 112 days 8 12.2 mg/100g 0.2 0.57 post excision weight measurement 0.0 0 102687 2703
LH/MavRrrc both kidneys wet weight to body weight ratio vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. kidney mass male 112 days 8 6.36 g/kg 0.08 0.23 post excision weight measurement 0.0 0 102693 2703
SS-Nppbem2Mcwi-/- heart left ventricle end-diastolic diameter vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-diastolic diameter male 168 days 7 8.68 mm 0.33 0.87 echocardiography 0.0 0 99770 2319
WF/Mol heart right ventricle weight vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 7 0.1 g 0.0 0.01 post excision weight measurement 0.0 acf 4 days 101412 2585
WF/Mol heart right ventricle weight vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 7 0.1 g 0.0 0.01 post excision weight measurement 0.0 acf 7 days 101416 2585
LL/Mav urine protein level to urine creatinine level ratio vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. total urine protein amount male 49 days-56 days 13 2.7 null 0.1 0.36 urine protein analysis 0.0 0 102653 2703
WKY/NHsd skin water level to skin dry weight ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin water amount male 0 days 7 1.43 ml/g 0.03 0.08 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin h2o ml/g 99141 2238
WKY/NHsd skin chloride level to skin water level ratio standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin chloride amount male 0 days 7 90.0 mmol/l 0.8 2.12 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin na/h2o 99147 2238
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 7 2.16 ml/min/100g 0.18 0.48 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99950 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 8 9.0 mmHg/ml/min 0.4 1.13 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99961 2378
SS-Nppbem2Mcwi-/- heart left ventricle weight vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle mass male 168 days 7 1.67 g 0.06 0.16 echocardiography 0.0 0 99812 2319
Hsd:WI spleen wet weight vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. spleen mass male 119 days-126 days 5 0.71 g 0.03 0.07 post excision weight measurement 0.0 0 76115 1545
Hsd:WI kidney glutathione peroxidase activity to total protein level ratio vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney glutathione peroxidase activity male 0 days 6 7.54 U/mg 0.51 1.24 liquid phase colorimetry 0.0 0 76192 1544
HanTac:WH litter size vehicle control condition (for 14 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. single birth offspring quantity female 0 days 18 11.8 null 0.78 3.3 in vivo visual assessment 0.0 0 96597 1559
HanTac:WH areola mammae/nipple number vehicle control condition (for 14 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. nipple quantity male 14 days 17 0.1 null 0.05 0.2 in vivo visual assessment 0.0 0 96627 1559
HanTac:WH body weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. body mass female 16 days-17 days 15 29.1 g 0.67 2.6 body weighing method 0.0 0 96687 1559
HanTac:WH right ovary wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. ovary mass female 16 days-17 days 15 2.9 mg 0.2 0.77 post excision weight measurement 0.0 0 right ovary 96692 1559
BluHsd:LE serum testosterone level vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. blood testosterone amount male 98 days 8 10.0 ng/ml 1.2 3.39 radioimmunoassay 0.0 0 tritium-based 76253 1543
Hsd:WI serum calcium level vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. blood calcium amount male 119 days-126 days 5 12.82 mg/dl 0.24 0.53 liquid phase colorimetry 0.0 0 76141 1545
Hsd:WI serum albumin level vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. blood albumin amount male 119 days-126 days 5 0.04 g/dl 0.0 0.0 liquid phase colorimetry 0.0 0 76149 1545
BluHsd:LE body weight gain vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. body mass male 71 days-98 days 8 145.3 g 9.3 26.3 body weighing method 0.0 0 76161 1543
BluHsd:LE total food calorie intake rate controlled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. eating behavior trait male 71 days-98 days 8 2995.2 kcal/d 187.0 528.92 unspecified method 0.0 0 76182 1543
HanTac:WH body weight gain vehicle control condition (for 14 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. body mass female 0 days 18 82.4 g 6.22 26.4 body weighing method 0.0 0 G7-G21 76270 1559
Hsd:WI right kidney wet weight to body weight ratio vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. kidney mass male 119 days-126 days 5 3.14 mg/g 0.06 0.13 post excision weight measurement 0.0 0 76080 1545
BluHsd:LE body weight gain vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. body mass male 71 days-98 days 8 104.6 g 5.9 16.69 body weighing method 0.0 0 75969 1543
Hsd:WI serum urea nitrogen level vehicle control condition (for 10 days) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. blood urea nitrogen amount male 0 days 6 69.64 mg/dl 2.5 6.12 liquid phase colorimetry 0.0 0 75976 1544
Hsd:WI serum urea nitrogen level vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. blood urea nitrogen amount male 0 days 6 96.11 mg/dl 1.91 4.69 liquid phase colorimetry 0.0 0 75977 1544
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure vehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) then phenylephrine (3 ug) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 50.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 84572 1120
HanTac:WH thyroid gland wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. thyroid gland mass female 16 days-17 days 15 4.7 mg 0.23 0.9 post excision weight measurement 0.0 0 left ovary 96707 1559
HanTac:WH number of fetuses lost perinatally to litter size ratio vehicle control condition (for 14 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. stillborn offspring quantity female 0 days 18 8.5 % 1.89 8.0 in vivo visual assessment 0.0 0 96592 1559
Hsd:WI both kidneys wet weight vehicle control condition (for 10 days) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney mass male 0 days 6 0.82 g 0.02 0.06 post excision weight measurement 0.0 0 75956 1544
SD heart rate sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart pumping trait male 0 days 6 380.0 beats/min 10.0 24.49 HP Sonos 5500 echo ultrasound 1.0 sham ACF 2 days 98802 2160
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc heart weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart mass male 126 days 0 4.67 g/kg 0.4 post excision weight measurement 0.0 0 102108 2646
SHRSP.WKY-(D3Mgh16-rs197649383)/Gcrc heart left ventricle weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart left ventricle mass male 126 days 0 3.57 mg/g 0.66 post excision weight measurement 0.0 0 102116 2646
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc heart left ventricle weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart left ventricle mass male 126 days 0 3.28 mg/g 0.19 post excision weight measurement 0.0 0 102117 2646
SHRSP/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 4.11 g/kg 0.25 post excision weight measurement 0.0 0 102118 2646
SS/NEisSlc both kidneys wet weight to body weight ratio controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. kidney mass male 126 days 8 5.19 g/kg 0.19 0.54 post excision weight measurement 0.0 0 102323 2684
Slc:W blood free fatty acids level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood free fatty acid amount male 105 days 0 9.99 mg/dl 0.72 blood free fatty acid analysis 0.0 0 ueq/l = umol/l 102882 2781
GK/Slc blood free fatty acids level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood free fatty acid amount male 105 days 0 12.55 mg/dl 0.52 blood free fatty acid analysis 0.0 0 ueq/l = umol/l 102884 2781
Slc:W urine acetoacetate level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. urine ketone body amount male 105 days 0 50.3 umol/l 2.6 urine analysis 0.0 0 n=4-6 102914 2781
PCK-Pkhd1pck/CrljCrl serum creatinine level control condition (for 28 days) then vehicle control condition (for 84 days) Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. blood creatinine amount male 112 days 5 0.51 mg/dl 0.04 0.09 serum creatinine analysis 0.0 0 100765 2521
Crl:CD(SD) urine total protein excretion rate control condition (for 28 days) then vehicle control condition (for 84 days) Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. total urine protein amount male 112 days 5 36.7 mg/d 3.5 7.83 urine protein analysis 0.0 0 100768 2521
WKY body weight left anterior descending coronary artery occlusion then vehicle control condition Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. body mass male 42 days-56 days 30 225.0 g 1.8 9.86 body weighing method 0.0 lad occlusion 0 days 100269 2460
WKY lung wet weight left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. lung mass male 238 days-252 days 30 2.13 g 0.13 0.71 post excision weight measurement 0.0 lad occlusion 196 days 100299 2460
SD creatinine clearance controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. glomerular filtration trait female 0 days 13 0.3 ml/min 0.03 0.11 serum creatinine analysis 0.0 unx 97 days 100642 2499
WKY/NCrl blood glucose level vehicle control condition (for 28 days) then fasting (for 16 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood glucose amount male 168 days 6 113.0 mg/dl 4.0 9.8 blood glucose test strip read by electrochemical glucometer 0.0 0 103510 2827
GK blood glucose level vehicle control condition (for 28 days) then fasting (for 16 hours) then glucose (2 g/kg) (for 2 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood glucose amount male 168 days 6 278.0 mg/dl 20.0 48.99 oral glucose tolerance test 0.0 0 103520 2827
WKY/NCrl systolic blood pressure vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 121.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103526 2827
WF/Mol heart rate vehicle control condition then artificial aortocaval fistula (for 9 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 7 460.0 beats/min 15.0 39.69 tail cuff plethysmography 0.0 acf 9 days 101375 2585
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 11 0.23 null 0.01 0.03 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99985 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 11 11.66 ml/d 1.01 3.34 metabolic cage urine volume measurement method 0.0 unx 168 days 100000 2378
LH/Mav systolic blood pressure vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. arterial blood pressure trait male 112 days 11 mean of 3 samples of undefined duration serial mean 160.0 mmHg 4.0 13.27 tail cuff plethysmography 0.0 0 102728 2721
LH/Mav urine albumin level to urine total protein level ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 11 16.0 % 2.4 7.96 urine albumin analysis 0.0 0 102744 2721
LL/Mav urine creatinine excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine creatinine amount male 112 days 9 11.1 mg/d 0.5 1.5 urine creatinine analysis 0.0 0 102746 2721
LH/Mav both kidneys wet weight to body weight ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. kidney mass male 112 days 11 6.24 g/kg 0.07 0.23 post excision weight measurement 0.0 0 102764 2721
LL/Mav blood glucose level vehicle control condition then fasting (for 16 hours) then glucose (2 g/kg) (for 1 hours) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood glucose amount male 56 days 9 136.0 mg/dl 4.0 12.0 blood glucose analysis 0.0 0 102718 2721
SS.ZUC-Leprfa+/+/Slc heart left ventricle weight to tibia length ratio bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle mass female 91 days 9 0.2 g/cm 0.01 0.02 post excision weight measurement 0.0 ovariectomy 42 days lv/tl 101695 2622
SS.ZUC-Leprfa+/+/Slc heart ventricle septal wall thickness bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle wall thickness female 91 days 9 0.16 cm 0.0 0.01 echocardiography 0.0 ovariectomy 42 days 101707 2622
SD left ventricular end-diastolic blood pressure artificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart left ventricular blood pressure trait male 0 days 6 13.0 mmHg 2.0 4.9 vascular transducer tipped catheter 1.0 ACF 2 days 98826 2160
SD heart left ventricle weight to body weight ratio artificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart left ventricle mass male 0 days 6 g/g*103 2.6 mg/g 0.1 0.24 post excision weight measurement 1.0 ACF 2 days 98874 2160
SS-Nppbem2Mcwi-/- heart left ventricle end-diastolic posterior wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle posterior wall thickness male 168 days 7 1.89 mm 0.16 0.42 echocardiography 0.0 0 99776 2319
SS-Nppbem2Mcwi-/- heart interventricular end-systolic septal wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart ventricle septum thickness male 84 days 7 3.19 mm 0.2 0.53 echocardiography 0.0 0 99780 2319
Crlj:WI mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 6 undefined 90.0 mmHg 8.0 19.6 vascular transducer tipped catheter 0.0 0 103019 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 136.0 mmHg 13.0 34.39 vascular transducer tipped catheter 0.0 0 103028 2784
Crlj:WI heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 379.0 beats/min 9.0 23.81 vascular transducer tipped catheter 0.0 0 103042 2784
GK heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 5 366.0 beats/min 17.0 38.01 vascular transducer tipped catheter 0.0 0 103045 2784
MW body weight unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. body mass male 0 days 7 220.0 g 9.0 23.81 body measuring method 0.0 unx 14 days 101142 2581
WF/Mol systolic blood pressure vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. arterial blood pressure trait male 0 days 7 undefined 116.0 mmHg 4.0 10.58 tail cuff plethysmography 0.0 acf 7 days 101350 2585
WF/Mol systolic blood pressure vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. arterial blood pressure trait male 0 days 6 undefined 122.0 mmHg 3.0 7.35 tail cuff plethysmography 0.0 acf 4 days 101360 2585
WF/Mol heart left ventricle weight vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart left ventricle mass male 0 days 8 0.26 g 0.01 0.01 post excision weight measurement 0.0 acf 4 days 101404 2585
WF/Mol heart left ventricle weight vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart left ventricle mass male 0 days 6 0.2 g 0.0 0.01 post excision weight measurement 0.0 sham acf 7 days 101409 2585
WKY/NCrl systolic blood pressure vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 126.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks nighttime measurement 103534 2827
GK heart rate vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 168 days 6 279.0 beats/min 3.0 7.35 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103560 2827
WKY/Gcrc urine urea level to urine creatinine level ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 18 68.85 null 9.11 38.65 urine urea analysis 0.0 0 103792 2646
GK logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 -7.29 null 0.09 0.26 wire myography 0.0 0 103588 2827
GK acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 67.1 % 3.32 9.39 wire myography 0.0 0 103592 2827
GK logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 -7.96 null 0.05 0.14 wire myography 0.0 0 103596 2827
GK sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 94.07 % 1.13 3.18 wire myography 0.0 0 103600 2827
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -8.15 null 0.09 0.24 wire myography 0.0 0 103610 2827
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 96.54 % 1.9 5.03 wire myography 0.0 0 103614 2827
WI neuron lysosome area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 8.3 % 0.19 0.38 ex vivo electron microscopy with digital image analysis 0.0 0 lys/cyto 103647 2844
WI neuron vacuole area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 3.97 % 0.34 0.68 ex vivo electron microscopy with digital image analysis 0.0 0 v/cyto 103656 2844
LL/Mav plasma triglyceride level vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood triglyceride amount male 112 days 13 1.58 mmol/l 0.13 0.47 plasma triglyceride analysis 0.0 0 102668 2703
LL/Mav both kidneys wet weight to body weight ratio vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. kidney mass male 112 days 13 6.53 g/kg 0.04 0.14 post excision weight measurement 0.0 0 102692 2703
SS.ZUC-Leprfa-/-/Slc retroperitoneal fat pad weight to tibia length ratio vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. retroperitoneal fat pad mass male 91 days 13 429.56 mg/mm 13.64 49.18 post excision weight measurement 0.0 0 rf/tl 101980 2644
SS.ZUC-Leprfa-/-/Slc epididymal fat pad weight to tibia length ratio vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. epididymal fat pad mass male 91 days 13 3.55 g/cm 0.1 0.35 post excision weight measurement 0.0 0 ef/tl 101983 2644
SS.ZUC-Leprfa-/-/Slc mesenteric fat pad weight to tibia length ratio vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. mesenteric fat pad mass male 91 days 13 364.22 mg/mm 10.33 37.25 post excision weight measurement 0.0 0 mf/tl 101986 2644
SS.ZUC-Leprfa-/-/Slc heart ventricle septal wall thickness vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricle wall thickness male 91 days 13 0.21 cm 0.0 0.01 echocardiography 0.0 0 101992 2644
SS/NEisSlc heart left ventricle fractional shortening controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. heart left ventricle end-diastolic diameter male 126 days 8 24.8 % 1.2 3.39 transthoracic echocardiography 0.0 0 102317 2684
WF/Mol heart rate vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 5 382.0 beats/min 8.0 17.89 tail cuff plethysmography 0.0 sham acf 7 days 101388 2585
WKY artery tunica media width to artery inner diameter ratio left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. kidney blood vessel morphology trait male 238 days-252 days 15 1.82 null 0.15 0.58 ex vivo light microscopy with histochemistry and digital image analysis 0.0 lad occlusion 196 days 100388 2460
LL/Mav body weight vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. body mass male 49 days-56 days 13 219.0 g 5.0 18.03 body weighing method 0.0 0 102641 2703
LL/Mav timed urine volume vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. urine output male 49 days-56 days 13 8.4 ml/d 0.3 1.08 urine volume measurement method 0.0 0 102647 2703
SS-Nppbem2Mcwi-/- heart left ventricle end-diastolic diameter vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-diastolic diameter male 84 days 7 7.52 mm 0.32 0.85 echocardiography 0.0 0 99768 2319
WF/Mol heart left ventricle weight vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 5 0.06 g 0.0 0.0 post excision weight measurement 0.0 sham acf 4 days 101413 2585
WF/Mol heart right ventricle weight vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 8 0.07 g 0.0 0.01 post excision weight measurement 0.0 acf 7 days 101430 2585
SS-Nppbem2Mcwi-/- mean arterial blood pressure vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. arterial blood pressure trait male 84 days 7 serial mean 142.0 mmHg 12.0 31.75 tail cuff plethysmography 0.0 0 99834 2319
WF/Mol body weight gain vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 5 34.0 g 2.0 4.47 body weighing method 0.0 7 days change from surgery weight 101329 2585
SS-Nppbem2Mcwi-/- ejection fraction vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. cardiac output trait male 252 days 7 77.4 % 6.0 15.87 echocardiography 0.0 0 99802 2319
SS.ZUC-Leprfa+/+/Slc tibia straight segment length bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. tibia length female 91 days 9 35.8 mm 0.4 1.2 body length measuring method 0.0 ovariectomy 42 days 101665 2622
SS.ZUC-Leprfa-/-/Slc heart rate bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 8 339.0 beats/min 11.0 31.11 tail cuff plethysmography 0.0 ovariectomy 42 days 101675 2622
SS.ZUC-Leprfa+/+/Slc heart weight to tibia length ratio bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart mass female 91 days 9 0.26 g/cm 0.01 0.02 post excision weight measurement 0.0 ovariectomy 42 days 101681 2622
SS.ZUC-Leprfa+/+/Slc heart left ventricle relative wall thickness bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle wall thickness female 91 days 9 44.0 % 2.0 6.0 echocardiography 0.0 ovariectomy 42 days 101727 2622
SS.ZUC-Leprfa+/+/Slc myocardial performance index bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 9 0.44 null 0.01 0.03 echocardiography 0.0 ovariectomy 42 days 101739 2622
SS-Nppbem2Mcwi-/- heart rate vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart pumping trait male 168 days 7 349.0 beats/min 20.0 52.92 echocardiography 0.0 0 99818 2319
SD-Nfe2l2em1Mcwi+/+ mean arterial blood pressure controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. arterial blood pressure trait male 9 days-11 days 4 95.0 mmHg 3.9 7.8 vascular fluid filled catheter 0.0 0 100739 2520
SD-Nfe2l2em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. arterial blood pressure trait male 9 days-11 days 3 102.0 mmHg 3.0 5.2 vascular fluid filled catheter 0.0 0 100740 2520
SD-Nfe2l2em1Mcwi+/+ middle cerebral artery inner diameter controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. cerebral artery size trait male 9 days-11 days 5 246.0 um 4.8 10.73 ex vivo method 0.0 0 max dilation 100745 2520
WKY/NHsd skin potassium level to skin water level ratio standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin potassium amount male 0 days 7 80.0 mmol/l 1.1 2.91 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin k/h2o 99155 2238
WKY/NHsd skin potassium level to skin water level ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin potassium amount male 0 days 7 71.0 mmol/l 3.0 7.94 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin k/h2o 99157 2238
WKY/NHsd plasma sodium level controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood sodium amount male 0 days 7 141.4 mmol/l 2.1 5.56 automated blood electrolyte analysis 0.0 0 99161 2238
WKY/NHsd plasma cystatin C level standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood cystatin C amount male 0 days 7 4.0 mg/l 0.6 1.59 automated plasma protein analysis 0.0 0 99175 2238
WKY/NHsd creatinine clearance standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. glomerular filtration trait male 0 days 7 3.1 ml/min 0.5 1.32 urine creatinine analysis 0.0 0 99179 2238
SS.ZUC-Leprfa-/-/Slc serum free fatty acids level vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood free fatty acid amount male 91 days 6 1.42 mmol/l 0.14 0.34 serum free fatty acid analysis 0.0 0 101953 2644
SS.ZUC-Leprfa-/-/Slc heart posterior wall thickness vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricle posterior wall thickness male 91 days 13 0.21 cm 0.01 0.02 echocardiography 0.0 0 101998 2644
SS.ZUC-Leprfa-/-/Slc time constant of left ventricular pressure decay vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricular blood pressure trait male 91 days 13 33.52 ms 1.09 3.93 echocardiography 0.0 0 102019 2644
WKY body weight unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 7 268.0 g 13.0 34.39 body weighing method 0.0 unx 28 days 99935 2378
WKY blood glucose level unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 7 74.0 mg/dl 2.0 5.29 machine read blood glucose test strip 0.0 unx 28 days 99940 2378
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 7 0.49 ml/min/100g 0.03 0.08 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99945 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 8 23.47 ml/d 1.73 4.89 metabolic cage urine volume measurement method 0.0 unx 28 days 99966 2378
WKY right kidney wet weight left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. kidney mass male 238 days-252 days 15 1.35 g 0.04 0.17 post excision weight measurement 0.0 lad occlusion 196 days 100359 2460
SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc urine potassium level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine potassium amount male 126 days 9 72.41 mmol/l 20.37 61.11 urine potassium analysis 0.0 0 102143 2646
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc urine potassium level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine potassium amount male 126 days 6 28.25 mmol/l 8.59 21.04 urine potassium analysis 0.0 0 102145 2646
SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc urine urea level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 9 228.93 mmol/l 62.26 186.78 urine urea analysis 0.0 0 102148 2646
WKY/NHsd skin sodium level to skin dry weight ratio standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin sodium amount male 0 days 7 0.11 REQUEST NEW VALUE 0.0 0.01 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin mmol/g 99131 2238
WKY/NHsd mean arterial blood pressure standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. arterial blood pressure trait male 0 days 7 101.0 mmHg 0.9 2.38 intra-aortic radiotelemetry 0.0 0 99187 2238
SS/JrHsdMcwi body weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. body mass male 56 days 7 261.0 g 6.0 15.87 body weighing method 0.0 0 106550 3032
SS-Sod3m1Mcwi tibia length vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. tibia length male 56 days 10 3.64 cm 0.03 0.09 post excision length measurement 0.0 0 106555 3032
SS-Sod3m1Mcwi left atrium weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left atrium mass male 56 days 10 0.02 g 0.0 0.0 post excision weight measurement 0.0 0 106567 3032
SS-Sod3m1Mcwi liver weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56 days 10 10.6 g 0.22 0.7 post excision weight measurement 0.0 0 106575 3032
SS/JrHsdMcwi heart right ventricle weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56 days 7 0.62 mg/g 0.03 0.08 post excision weight measurement 0.0 0 106582 3032
SD-Abcb1aem1Sage-/- brain uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. blood-brain barrier morphology trait male 42 days-56 days 3 75.0 % 5.8 10.05 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106165 3028
SD-Ahrem2Sage thymus weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. thymus mass female 84 days 10 1.61 mg/g 0.19 0.6 post excision weight measurement 0 105885 3021
SD-Ahrem2Sage spleen weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. spleen mass female 84 days 10 0.29 % 0.02 0.07 post excision weight measurement 0 105897 3021
SS-Sod3m1Mcwi heart right ventricle weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56 days 10 0.61 mg/g 0.01 0.03 post excision weight measurement 0.0 0 106583 3032
SS/JrHsdMcwi heart left ventricle weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left ventricle mass male 56 days 7 2.43 mg/g 0.05 0.13 post excision weight measurement 0.0 0 106586 3032
SS/JrHsdMcwi heart left atrium weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left atrium mass male 56 days 7 0.06 mg/g 0.01 0.03 post excision weight measurement 0.0 0 106598 3032
SD retinal uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina blood vessel morphology trait male 35 days-49 days 3 212.0 % 13.0 22.52 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106114 3028
SD retinal uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina blood vessel morphology trait male 35 days-49 days 3 336.0 % 7.0 12.12 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106120 3028
SD-Abcb1aem1Sage-/- retinal uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina blood vessel morphology trait male 42 days-56 days 3 227.0 % 25.0 43.3 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106123 3028
SD aqueous humor uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. aqueous humor morphology trait male 35 days-49 days 3 5.95 % 0.38 0.66 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106132 3028
SD-Abcb1aem1Sage-/- aqueous humor uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. aqueous humor morphology trait male 42 days-56 days 3 24.8 % 1.4 2.42 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106147 3028
SD brain uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. blood-brain barrier morphology trait male 35 days-49 days 3 0.99 % 0.35 0.61 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106153 3028
SS-Sod3m1Mcwi heart right atrium weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56 days 10 0.41 mg/mm 0.03 0.09 post excision weight measurement 0.0 0 106623 3032
SS/JrHsdMcwi right ventricular end-systolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricular blood pressure trait male 56 days 6 26.0 mmHg 0.99 2.42 vascular fluid filled catheter 0.0 0 106796 3032
SS/JrHsdMcwi heart rate vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart pumping trait male 56 days 6 358.0 beats/min 7.95 19.47 vascular fluid filled catheter 0.0 0 106798 3032
SS/JrHsdMcwi systolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56 days 6 115.0 mmHg 4.76 11.66 vascular fluid filled catheter 0.0 0 106802 3032
Crl:CD(SD) full retina thickness vehicle control condition (0 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59 days-66 days 5 129.7 um 3.71 8.3 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 full retina layer 105438 3016
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67 days-74 days 5 128.7 um 4.92 11.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography inner retinal layer 105478 3016
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111 days-118 days 5 121.9 um 4.38 9.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography inner retinal layer 105494 3016
SD-Ahrem2Sage red blood cell count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 7.41 x 10E6 cells/ul 0.36 1.14 automated hematology analysis 0 105933 3021
Hsd:SD hematocrit vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 43.31 % 1.49 4.71 automated hematology analysis 0 105956 3021
RCS-p+/LavRrrc photopic B wave amplitude of ERG waveform vehicle control condition (2 ul) then visible light stimulus (25 cd x s/m2) Baranov P, et al., J Ocul Pharmacol Ther. 2017 Jun;33(5):412-422. doi: 10.1089/jop.2016.0121. Epub 2017 Apr 25. cone electrophysiology trait not specified 119 days 7 23.1 uV 1.0 2.65 electroretinography cornea 0.0 intravitrial injection 98 days 109739 3154
SHRSP/A3N kidney glomerular lesion count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney glomerulus integrity trait male 126 days-182 days 0 76.5 /section 7.0 ex vivo light microscopy with histochemistry renal glomerulus 0.0 0 107539 3090
SHRSP/A3N kidney total tubule cast count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 349.0 /section 45.0 ex vivo light microscopy with histochemistry 0.0 0 107555 3090
WAG/Nov spleen cell count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. spleen morphology trait male 150 days-180 days 10 707.11 x10E6/organ 150.29 475.26 isolated cell counting method 0.0 IP injection 1 days saline 107700 3096
ISIAH spleen cell count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. spleen morphology trait male 150 days-180 days 10 583.56 x10E6/organ 109.7 346.9 isolated cell counting method 0.0 IP injection 1 days saline 107703 3096
WAG/Nov CD3+ thymocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymocyte quantity male 150 days-180 days 10 1021.26 x10E6/organ 145.57 460.33 flow cytometry method 0.0 IP injeciton 1 days saline cd3+ thymocyte 107715 3096
SHRSP/A3NCrl time to peak measurement of Gd-DTPA uptake by kidney cortex controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. xenobiotic metabolism trait male 161 days-175 days 6 14.3 s 1.2 17.98 Dynamic Contrast-Enhanced Magnetic Resonance Imaging cortex of kidney 400.0 0 5 seconds x 10 measurements averaged x 8 regions 5 seconds x 10 measurements averaged x 8 regions 107374 3083
SHRSP/A3NCrl multiregional glomerular filtration rate index controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (between 35 and 63 days) Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. glomerular filtration trait male 161 days-175 days 6 dCm/dt = KclCc(t) 2.25 mmol/min 0.14 0.34 Dynamic Contrast-Enhanced Magnetic Resonance Imaging 400.0 0 5 sec x 10 measurements x 8 regions glomerular filtration rate index 107379 3083
SS/NEisSlc neuron count vehicle control condition (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. hippocampus neuron quantity not specified 547 days 10 1258.0 cells/mm2 32.0 101.19 ex vivo light microscopy with histochemistry 0.0 0 107465 2339
MWF/FubRkb timed urine volume vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. urine output male 114 days 10 10.1 ml/d 0.4 1.26 metabolic cage urine volume measurement method 0.0 0 109401 3140
Crl:WI systolic blood pressure vehicle control condition (10 mg/kg/d) (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. arterial blood pressure trait male 112 days 10 126.9 mmHg 4.0 12.65 tail cuff plethysmography 0.0 0 109407 3140
MWF/FubRkb acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasodilation trait male 114 days 10 82.3 % 3.0 9.49 wire myography mesenteric artery 0.0 0 109433 3140
WAG/Nov CD4+CD8- thymocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymocyte quantity male 150 days-180 days 10 239.75 x 10E6/organ 50.38 159.32 flow cytometry method 0.0 IP injeciton 1 days saline cd4+cd8- t-cell 107718 3096
WAG/Nov CD4+CD25+ thymocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymocyte quantity male 150 days-180 days 10 40.63 x10E6/organ 7.77 24.57 flow cytometry method 0.0 IP injeciton 1 days saline cd4+cd25+ t-cell 107727 3096
ISIAH CD45RA+ splenocyte count to total splenocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 34.86 % 1.36 4.3 flow cytometry method 0.0 IP injeciton 1 days saline cd45 RA+ spleen 107745 3096
ISIAH CD4+CD25+ splenocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 9.83 x10E6/organ 0.94 2.97 flow cytometry method 0.0 IP injeciton 1 days saline cd4+cd25+ spleen 107751 3096
WAG/Nov plasma triglyceride level vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. blood triglyceride amount male 150 days-180 days 10 1.19 mmol/l 0.09 0.29 plasma triglyceride analysis 0.0 IP injeciton 1 days saline 107775 3096
ISIAH plasma triglyceride level vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. blood triglyceride amount male 150 days-180 days 10 1.3 mmol/l 0.12 0.36 plasma triglyceride analysis 0.0 IP injeciton 1 days saline 107778 3096
BDIX/CrCrl total white blood cell count DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. leukocyte quantity male 71 days 10 12.9 x 1000 cells/ul 0.63 2.0 automated total white blood cell count test 0.0 0 WBC 107826 3097
BDIX/CrCrl mean corpuscular hemoglobin DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood hemoglobin amount male 71 days 10 18.0 pg 0.06 0.2 blood hemoglobin analysis 0.0 0 hemoglobin, MCH, MCHC 107836 3097
Crl:WI body weight vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. body mass male 112 days 10 391.8 g 17.2 54.39 body weighing method 0.0 0 109387 3140
BDIX/CrCrl blood lymphocyte count to total leukocyte count ratio DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. lymphocyte quantity male 92 days 10 8.0 % 0.09 0.3 automated differential white blood cell count test 0.0 0 LYM 107853 3097
BDIX/CrCrl serum triglyceride level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood triglyceride amount male 92 days 10 249.0 mg/dl 6.96 22.0 automated serum analysis 0.0 0 serum triglyceride level 107899 3097
BDIX/CrCrl serum alkaline phosphatase activity level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood alkaline phosphatase amount male 92 days 10 620.0 U/l 7.27 23.0 automated serum analysis 0.0 0 serum alkaline phosphatase 107914 3097
Hsd:SD scotopic B wave amplitude of ERG waveform vehicle control condition (2 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. rod electrophysiology trait both 0 days 4 338.0 uV electroretinography cornea 0.0 subretinal injection 30 days scotopic b-wave ERG 108640 3128
BDIX/CrCrl hematocrit DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. erythrocyte quantity male 71 days 10 52.3 % 0.95 3.0 hematocrit analysis 0.0 0 red blood cell count, hematocrit 107811 3097
WKY body weight unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 17 256.0 g 5.0 20.62 body weighing method 0.0 unx 150 days 107446 2378
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 17 19.3 x 10E3 um2 4.8 19.79 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107461 2378
BDIX/CrCrl serum urea nitrogen level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood urea nitrogen amount male 92 days 10 34.5 mg/dl 0.41 1.3 automated serum analysis 0.0 0 serum BUN 107889 3097
WKY heart weight to body weight ratio unilateral nephrectomy (for 150 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. heart mass male 0 days 11 2.4 g/kg 0.1 0.33 post excision weight measurement 0.0 unx 150 days 107450 2378
LOU/MWsl subcutaneous tumor diameter measurement rat IgM immunocytoma cells (0.01 x 10E6 cells) (for 18 days) then vehicle control condition (1 ml/kg) (for 28 days) van Hoesel QG, etal., J Natl Cancer Inst. 1984 May;72(5):1141-50. hypodermis integrity trait male 130 days 8 37.2 mm 1.13 3.2 in vivo caliper method hindlimb 0.0 28 days mean of 3 measurements 109745 3155
BDIX/CrCrl serum triglyceride level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood triglyceride amount male 71 days 10 265.0 mg/dl 8.22 26.0 automated serum analysis 0.0 0 serum triglyceride level 107897 3097
BDIX/CrCrl serum aspartate aminotransferase activity level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood aspartate transaminase amount male 92 days 10 193.0 U/l 8.22 26.0 automated serum analysis 0.0 0 serum aspartate aminotransferase 107904 3097
BDIX/CrCrl serum total bilirubin level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood bilirubin amount male 71 days 10 0.4 mg/dl 0.03 0.1 automated serum analysis 0.0 0 serum bilirubin 107924 3097
BDIX/CrCrl serum lactate dehydrogenase activity level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood lactate dehydrogenase amount male 71 days 10 964.0 U/l 31.31 99.0 automated serum analysis 0.0 0 107929 3097
BDIX/CrCrl serum lactate dehydrogenase activity level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood lactate dehydrogenase amount male 92 days 10 2717.0 U/l 163.17 516.0 automated serum analysis 0.0 0 107931 3097
BDIX/CrCrl blood lymphocyte count DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. lymphocyte quantity male 92 days 10 77.7 x 1000 cells/ul 0.63 2.0 automated differential white blood cell count test 0.0 0 LYM 107863 3097
WKY left kidney wet weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney mass male 0 days 17 9.9 mg/g 0.7 2.89 post excision weight measurement 0.0 unx 150 days 107456 2378
LOU/MWsl serum albumin level rat IgM immunocytoma cells (0.01 x 10E6 cells) (for 18 days) then vehicle control condition (1 ml/kg) (for 7 days) van Hoesel QG, etal., J Natl Cancer Inst. 1984 May;72(5):1141-50. blood albumin amount male 109 days 5 219.0 g/dl 13.86 31.0 gel electrophoresis 0.0 0 109761 3155
WAG/OlaHsd metastatic intraperitoneal tumor weight CC531 cells (5 X 10E6) (for 21 days) then vehicle control condition (1 ml) (for 21 days) Pross M, et al., Surg Endosc. 2001 Aug;15(8):882-5. doi: 10.1007/s004640090029. Epub 2001 May 2. peritoneum integrity trait male 0 days 16 abdominal lesion weight 7.42 g 0.25 1.01 necropsy 0.0 IP injection 21 days CC531 cells 107874 3098
ISIAH blood non-specified leukocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. leukocyte quantity male 150 days-180 days 10 2.96 10E3/ul 0.99 3.13 white blood cell counting method 0.0 IP injection 1 days saline 107696 3096
BDIX/CrCrl serum alkaline phosphatase activity level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood alkaline phosphatase amount male 71 days 10 476.0 U/l 1.58 5.0 automated serum analysis 0.0 0 serum alkaline phosphatase 107912 3097
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 11 12.6 x 10E3 um2 3.8 12.6 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107460 2378
Hsd:WI serum total bilirubin level vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. blood bilirubin amount male 119 days-126 days 5 0.96 mg/dl 0.07 0.17 liquid phase colorimetry 0.0 0 76156 1545
BluHsd:LE food intake weight to change in body weight ratio controlled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. eating behavior trait male 71 days-98 days 8 4.7 g/g 0.2 0.57 unspecified method 0.0 0 76197 1543
BluHsd:LE serum testosterone level vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. blood testosterone amount male 98 days 8 7.3 ng/ml 1.5 4.24 radioimmunoassay 0.0 0 tritium-based 76252 1543
Crl:CD(SD) serum progesterone level maternal milk (for 20 days) and vehicle control condition (for 15 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. blood progesterone amount female 50 days 32 12.5 ng/ml 2.8 15.84 radioimmunoassay 0.0 0 76262 1558
Crl:CD(SD) mammary tumor number maternal milk (for 20 days) and vehicle control condition (for 15 days) then 7,12-dimethyltetraphene (DMBA) (30 mg/kg) (for 1 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. mammary gland integrity trait female 0 days-365 days 32 2.84 null 0.31 1.75 manual palpation method 0.0 0 76264 1558
WKY plasma creatinine level left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. blood creatinine amount male 238 days-252 days 6 0.52 mg/dl 0.04 0.1 plasma creatinine analysis 0.0 lad occlusion 196 days 100365 2460
SS.ZUC-Leprfa-/-/Slc E wave deceleration time vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood flow trait male 91 days 13 53.05 ms 1.48 5.34 echocardiography 0.0 0 102013 2644
Crl:CD(SD) retinal outer nuclear layer thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 81 days-88 days 5 53.4 um 2.33 5.2 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 outer nuc layer 105442 3016
SD heart rate artificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart pumping trait male 0 days 6 420.0 beats/min 14.0 34.29 HP Sonos 5500 echo ultrasound 1.0 ACF 2 days 98801 2160
LH/Mav renal vascular resistance to kidney weight ratio vehicle control condition then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. kidney blood vessel physiology trait male 84 days 8 SBP/RBF 33.0 ml/min/g/mmHg 2.0 5.66 ultrasonic flowmeter 0.0 0 102857 2761
SD aqueous humor uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. aqueous humor morphology trait male 35 days-49 days 3 8.46 % 0.61 1.06 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106138 3028
SD-Abcb1aem1Sage-/- aqueous humor uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. aqueous humor morphology trait male 42 days-56 days 3 12.0 % 0.6 1.04 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106141 3028
Hsd:SD blood basophil count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. basophil quantity female 84 days 10 0.07 x 1000 cells/ul 0.03 0.09 automated hematology analysis 0 106076 3021
WKY body weight left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. body mass male 238 days-252 days 30 617.0 g 52.0 284.82 body weighing method 0.0 lad occlusion 196 days 100272 2460
LL/Mav timed urine volume vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine output male 56 days 9 9.1 ml/d 0.4 1.2 urine volume measurement method 0.0 0 102706 2721
Crl:CD(SD) blood urea nitrogen level control condition (for 28 days) then vehicle control condition (for 84 days) Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. blood urea nitrogen amount male 112 days 5 19.3 mg/dl 2.6 5.81 blood urea nitrogen analysis 0.0 0 100764 2521
Crl:CD(SD) urine protein level to urine creatinine level ratio control condition (for 28 days) then vehicle control condition (for 84 days) Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. total urine protein amount male 112 days 5 1.98 null 0.31 0.69 urine protein analysis 0.0 0 100770 2521
SS-Nppbem2Mcwi-/- heart left ventricle end-systolic posterior wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle posterior wall thickness male 84 days 7 3.29 mm 0.19 0.5 echocardiography 0.0 0 99792 2319
LL/Mav blood glucose level vehicle control condition then fasting (for 16 hours) then glucose (2 g/kg) (for 1 hours) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood glucose amount male 49 days-56 days 13 132.0 mg/dl 4.0 14.42 blood glucose analysis 0.0 0 102659 2703
WKY hematocrit unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. erythrocyte quantity male 0 days 11 45.2 % 1.4 4.64 hematocrit analysis 0.0 unx 168 days 99975 2378
MW blood urea nitrogen level unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. blood urea nitrogen amount male 0 days 7 25.0 mg/dl 1.0 2.65 blood urea nitrogen analysis 0.0 unx 14 days 101178 2581
MW urine total protein excretion rate unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. total urine protein amount male 0 days 7 23.0 mg/d 2.0 5.29 Bradford protein assay 0.0 unx 42 days 101196 2581
WKY/Izm absolute change in heart rate air-jet exposure (for 0 hours) then vehicle control condition (2 ul) (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. heart pumping trait male 98 days 6 0.0 beats/min 6.0 14.7 vascular indwelling catheter method 0.0 0 84562 1120
Hsd:WI timed urine volume vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. urine output male 0 days 6 21.8 ml/d 1.31 3.2 urine volume measurement method 0.0 0 75966 1544
SS.ZUC-Leprfa-/-/Slc heart left ventricle weight to tibia length ratio bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle mass female 91 days 8 0.28 g/cm 0.01 0.02 post excision weight measurement 0.0 ovariectomy 42 days lv/tl 101697 2622
SS.ZUC-Leprfa-/-/Slc inguinal fat pad weight to tibia length ratio bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. inguinal fat pad mass female 91 days 8 209.0 mg/mm 12.0 33.94 post excision weight measurement 0.0 ovariectomy 42 days sf/tl 101705 2622
WKY/NHsd plasma chloride level standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood chloride amount male 0 days 7 98.2 mmol/l 1.1 2.91 automated blood electrolyte analysis 0.0 0 99167 2238
SS-Nppbem2Mcwi-/- heart left ventricle fractional shortening vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-diastolic diameter male 252 days 7 41.6 % 5.6 14.82 echocardiography 0.0 0 99808 2319
SD-Nfe2l2em1Mcwi+/+ percent change in middle cerebral artery inner diameter controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) then physiological salt solution perfusate Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. cerebral artery size trait male 9 days-11 days 5 41.4 % 4.47 10.0 ex vivo method 0.0 0 tone 100757 2520
WKY/Gcrc water drink intake rate vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. drinking behavior trait male 126 days 18 53.12 ml/d 30.74 130.42 metabolic cage water drinking measurement method 0.0 0 102127 2646
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc timed urine volume vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine output male 126 days 6 55.86 ml/d 8.67 21.24 metabolic cage urine volume measurement method 0.0 0 102135 2646
WF/Mol body weight vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 5 188.0 g 1.0 2.24 body weighing method 0.0 4 days 101303 2585
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 8 0.26 null 0.01 0.04 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99956 2378
WKY/NHsd skin potassium level plus skin sodium level to skin water level ratio standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin mineral amount male 0 days 7 0.17 null 0.0 0.0 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin na+k/h2o 99143 2238
SHRSP/Gcrc urine urea level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 17 131.16 mmol/l 57.62 237.57 urine urea analysis 0.0 0 102146 2646
Hsd:WI kidney glutathione peroxidase activity to total protein level ratio vehicle control condition (for 10 days) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney glutathione peroxidase activity male 0 days 6 22.63 U/mg 1.35 3.3 liquid phase colorimetry 0.0 0 76191 1544
Hsd:WI kidney lipid peroxide level vehicle control condition (for 10 days) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney lipid peroxide amount male 0 days 6 0.75 nmol/mg 0.02 0.04 liquid phase colorimetry 0.0 0 76256 1544
BluHsd:LE both testes wet weight vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. testis mass male 98 days 8 3.4 g 0.2 0.57 post excision weight measurement 0.0 0 76249 1543
Hsd:WI kidney catalase activity to total protein level ratio vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. catalase activity male 0 days 6 21.73 nmol/mg 0.62 1.51 liquid phase colorimetry 0.0 0 76235 1544
Hsd:WI serum lactate dehydrogenase activity level vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. blood lactate dehydrogenase amount male 119 days-126 days 5 1068.0 U/l 313.23 700.4 liquid phase colorimetry 0.0 0 76177 1545
HanTac:WH retroperitoneal fat pad weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. retroperitoneal fat pad mass female 16 days-17 days 15 0.03 g 0.0 0.01 post excision weight measurement 0.0 0 96712 1559
Hsd:WI body weight vehicle control condition (for 10 days) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. body mass male 0 days 6 140.6 g 0.53 1.3 body weighing method 0.0 0 75951 1544
Hsd:WI body weight vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. body mass male 0 days 6 137.6 g 0.45 1.1 body weighing method 0.0 0 75952 1544
Hsd:WI timed urine volume vehicle control condition (for 10 days) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. urine output male 0 days 6 6.8 ml/d 0.61 1.5 urine volume measurement method 0.0 0 75965 1544
Hsd:WI serum creatinine level vehicle control condition (for 10 days) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. blood creatinine amount male 0 days 6 0.54 mg/dl 0.01 0.03 serum creatinine analysis 0.0 0 75972 1544
WKY/Izm absolute change in mean arterial blood pressure air-jet exposure (for 0 hours) then vehicle control condition (2 ul) (for 0 hours) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 -3.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84553 1120
HanTac:WH number of perinatal live-born offspring deaths to litter size ratio vehicle control condition (for 14 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. total life span female 0 days 18 3.2 % 1.27 5.4 in vivo visual assessment 0.0 0 96602 1559
HanTac:WH combined levator ani and bulbocavernosus muscle weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. skeletal muscle mass male 16 days-17 days 18 26.0 mg 1.04 4.4 post excision weight measurement 0.0 0 96662 1559
HanTac:WH both adrenal glands wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. adrenal gland mass male 16 days-17 days 18 7.5 mg 0.49 2.1 post excision weight measurement 0.0 0 96677 1559
HanTac:WH retroperitoneal fat pad weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. retroperitoneal fat pad mass male 16 days-17 days 18 0.04 g 0.0 0.01 post excision weight measurement 0.0 0 96682 1559
SHRSP.WKY-(D3Mgh16-D3Wox3)/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 7 3.77 g/kg 0.15 0.4 post excision weight measurement 0.0 0 102161 2646
SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc heart weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart mass male 126 days 0 4.03 g/kg 0.28 post excision weight measurement 0.0 0 102102 2646
SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc heart weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart mass male 126 days 0 4.26 g/kg 0.3 post excision weight measurement 0.0 0 102106 2646
SHRSP.WKY-(D3Mgh16-rs197649383)/Gcrc heart weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart mass male 126 days 0 4.72 g/kg 0.64 post excision weight measurement 0.0 0 102107 2646
SHRSP.WKY-(D3Mgh16-D3Wox3)/Gcrc heart left ventricle weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart left ventricle mass male 126 days 7 3.0 mg/g 0.11 0.29 post excision weight measurement 0.0 0 102114 2646
WKY/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 2.87 g/kg 0.23 post excision weight measurement 0.0 0 102119 2646
SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 3.65 g/kg 0.2 post excision weight measurement 0.0 0 102120 2646
SHRSP.WKY-(D3Wox20-D3Rat114)/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 6 3.78 g/kg 0.18 0.44 post excision weight measurement 0.0 0 102121 2646
LH/Mav renal blood flow rate to kidney weight ratio vehicle control condition then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. renal blood flow trait male 84 days 8 5.0 ml/min/g 0.3 0.85 ultrasonic flowmeter 0.0 0 102853 2761
Slc:W blood glycated albumin level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood albumin amount male 105 days 0 1.5 % 0.05 blood protein analysis 0.0 0 glycated albumin n=4-6 102874 2781
GK/Slc blood glycated albumin level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood albumin amount male 105 days 0 2.3 % 0.07 blood protein analysis 0.0 0 glycated albumin n=4-6 102876 2781
Slc:W blood hemoglobin A1c level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood hemoglobin amount male 105 days 0 5.32 % 0.13 blood hemoglobin analysis 0.0 0 HbA1c n=4-6 102878 2781
GK/Slc blood triglyceride level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood triglyceride amount male 105 days 0 52.3 mg/dl 7.4 blood triglyceride analysis 0.0 0 n=4-6 102888 2781
Slc:W blood total cholesterol level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood cholesterol amount male 105 days 0 67.0 mg/dl 3.5 blood cholesterol analysis 0.0 0 n=4-6 102890 2781
GK/Slc blood high density lipoprotein cholesterol level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood HDL cholesterol amount male 105 days 0 9.0 mg/dl 0.9 blood high-density lipoprotein-cholesterol measurement test 0.0 0 n=4-6 102896 2781
GK/Slc blood creatinine level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood creatinine amount male 105 days 0 0.26 mg/dl 0.02 blood creatinine analysis 0.0 0 n=4-6 102908 2781
GK/Slc urine acetoacetate level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. urine ketone body amount male 105 days 0 91.5 umol/l 39.9 urine analysis 0.0 0 n=4-6 102916 2781
Slc:W timed urine volume vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. urine output male 105 days 0 11.2 ml/d 0.5 urine volume measurement method 0.0 0 n=4-6 102922 2781
Slc:W urine glucose level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. urine glucose amount male 105 days 0 31.8 mg/dl 3.4 blood glucose test strip read by electrochemical glucometer 0.0 0 n=4-6 102926 2781
GK/Slc urine glucose level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. urine glucose amount male 105 days 0 588.3 mg/dl 349.4 blood glucose test strip read by electrochemical glucometer 0.0 0 n=4-6 102928 2781
LH/Mav timed urine volume vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine output male 112 days 11 11.6 ml/d 0.4 1.33 urine volume measurement method 0.0 0 102732 2721
LL/Mav plasma creatinine level vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood creatinine amount male 112 days 9 0.5 mg/dl 0.01 0.03 plasma creatinine analysis 0.0 0 102758 2721
LL/Mav heart left ventricle weight to body weight ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. heart left ventricle mass male 112 days 9 1.88 mg/g 0.0 0.01 post excision weight measurement 0.0 0 102766 2721
PCK-Pkhd1pck/CrljCrl urine protein level to urine creatinine level ratio control condition (for 28 days) then vehicle control condition (for 84 days) Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. total urine protein amount male 112 days 6 12.0 null 1.7 4.16 urine protein analysis 0.0 0 100769 2521
WF/Mol systolic blood pressure vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. arterial blood pressure trait male 0 days 5 undefined 130.0 mmHg 2.0 4.47 tail cuff plethysmography 0.0 sham acf 7 days 101351 2585
WF/Mol heart rate vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 5 406.0 beats/min 22.0 49.19 tail cuff plethysmography 0.0 sham acf 4 days 101369 2585
WF/Mol heart rate vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 5 358.0 beats/min 12.0 26.83 tail cuff plethysmography 0.0 sham acf 7 days 101373 2585
WF/Mol heart left ventricle weight vehicle control condition then sham surgical control condition (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart left ventricle mass male 0 days 6 0.21 g 0.0 0.01 post excision weight measurement 0.0 sham acf 2 days 101401 2585
SS-Nppbem2Mcwi-/- heart interventricular end-diastolic septal wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart ventricle septum thickness male 168 days 7 1.92 mm 0.12 0.32 echocardiography 0.0 0 99764 2319
GK mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 147.0 mmHg 7.0 18.52 vascular transducer tipped catheter 0.0 0 103018 2784
GK mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 111.0 mmHg 5.0 13.23 vascular transducer tipped catheter 0.0 0 103022 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 6 undefined 120.0 mmHg 7.0 17.15 vascular transducer tipped catheter 0.0 0 103031 2784
Crlj:WI heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 6 372.0 beats/min 11.0 26.94 vascular transducer tipped catheter 0.0 0 103035 2784
Crlj:WI heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) then meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 6 288.0 beats/min 11.0 26.94 vascular transducer tipped catheter 0.0 0 103047 2784
WF/Mol heart left ventricle weight vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart left ventricle mass male 0 days 5 0.22 g 0.01 0.02 post excision weight measurement 0.0 sham acf 4 days 101391 2585
SS.ZUC-Leprfa+/+/Slc retroperitoneal fat pad weight to tibia length ratio bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. retroperitoneal fat pad mass female 91 days 9 105.0 mg/mm 9.0 27.0 post excision weight measurement 0.0 ovariectomy 42 days vf/tl 101699 2622
SS.ZUC-Leprfa-/-/Slc retroperitoneal fat pad weight to tibia length ratio bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. retroperitoneal fat pad mass female 91 days 8 482.0 mg/mm 18.0 50.91 post excision weight measurement 0.0 ovariectomy 42 days vf/tl 101701 2622
SS.ZUC-Leprfa-/-/Slc heart ventricle septal wall thickness bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle wall thickness female 91 days 8 0.21 cm 0.0 0.01 echocardiography 0.0 ovariectomy 42 days 101709 2622
GK serum fructosamine level vehicle control condition (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood fructosamine amount male 175 days 6 187.0 umol/l 9.0 22.05 serum fructosamine analysis 0.0 0 103504 2827
WF/Mol heart rate vehicle control condition then sham surgical control condition (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 6 377.0 beats/min 11.0 26.94 tail cuff plethysmography 0.0 sham acf 2 days 101379 2585
WF/Mol heart right ventricle weight vehicle control condition then artificial aortocaval fistula (for 9 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 7 0.09 g 0.0 0.01 post excision weight measurement 0.0 acf 9 days 101419 2585
WKY blood glucose level unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 11 76.0 mg/dl 1.0 3.32 machine read blood glucose test strip 0.0 unx 168 days 99970 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 11 2.28 ml/min/100g 0.07 0.23 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99990 2378
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 89.88 % 2.56 6.77 wire myography 0.0 0 103590 2827
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 99.75 % 2.32 6.14 wire myography 0.0 0 103606 2827
GK acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 96.96 % 2.2 6.22 wire myography 0.0 0 103608 2827
GK logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 -8.74 null 0.57 1.61 wire myography 0.0 0 103612 2827
WKY/NCrl mesenteric artery phosphorylated eNOS level to total eNOS level ratio vehicle control condition (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. artery molecular composition trait male 175 days 7 0.94 null 0.13 0.34 western blot assay 0.0 0 103622 2827
WI neuron mitochondrion area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 10.4 % 0.16 0.32 ex vivo electron microscopy with digital image analysis 0.0 0 mito/cyto 103644 2844
OXYS/Nov neuron lysosome area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 11.9 % 0.39 0.78 ex vivo electron microscopy with digital image analysis 0.0 0 lys/cyto 103648 2844
GK systolic blood pressure vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 145.0 mmHg 4.0 9.8 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks nighttime measurement 103536 2827
GK diastolic blood pressure vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 98.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103544 2827
WKY right kidney wet weight left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. kidney mass male 238 days-252 days 15 1.35 g 0.04 0.17 post excision weight measurement 0.0 lad occlusion 196 days 100373 2460
WKY plasma creatinine level left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. blood creatinine amount male 238 days-252 days 6 0.52 mg/dl 0.04 0.1 plasma creatinine analysis 0.0 lad occlusion 196 days 100379 2460
SS-Nppbem2Mcwi-/- heart left ventricle end-diastolic posterior wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle posterior wall thickness male 84 days 7 2.03 mm 0.06 0.16 echocardiography 0.0 0 99774 2319
WF/Mol heart right ventricle weight vehicle control condition then sham surgical control condition (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 6 0.05 g 0.0 0.0 post excision weight measurement 0.0 sham acf 2 days 101423 2585
WKY body weight vehicle control condition (1 null) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. body mass male 156 days 10 450.39 g 9.36 29.6 body weighing method 0.0 0 99107 2219
SD maximum rate of positive change in left ventricular blood pressure sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart left ventricular blood pressure trait male 0 days 6 8231.0 mmHg/s 423.0 1036.13 vascular transducer tipped catheter 1.0 sham ACF 2 days 98887 2160
SD maximum rate of negative change in left ventricular blood pressure artificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart left ventricular blood pressure trait male 0 days 6 -6032.0 mmHg/s 387.0 947.95 vascular transducer tipped catheter 1.0 ACF 2 days 98890 2160
SS-Nppbem2Mcwi-/- systolic blood pressure vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. arterial blood pressure trait male 84 days 7 serial mean 172.0 mmHg 13.0 34.39 tail cuff plethysmography 0.0 0 99828 2319
SS-Nppbem2Mcwi-/- mean arterial blood pressure vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. arterial blood pressure trait male 168 days 7 serial mean 158.0 mmHg 27.0 71.44 tail cuff plethysmography 0.0 0 99836 2319
LH/Mav urine protein level to urine creatinine level ratio vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. total urine protein amount male 49 days-56 days 8 5.9 null 0.5 1.41 urine protein analysis 0.0 0 102654 2703
LL/Mav plasma total cholesterol level vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood cholesterol amount male 112 days 13 50.58 mg/dl 2.7 9.74 blood cholesterol analysis 0.0 0 102662 2703
LH/Mav plasma total cholesterol level vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood cholesterol amount male 112 days 8 66.41 mg/dl 5.41 15.29 blood cholesterol analysis 0.0 0 102663 2703
SS-Nppbem2Mcwi-/- heart left ventricle fractional shortening vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-diastolic diameter male 168 days 7 44.3 % 2.8 7.41 echocardiography 0.0 0 99806 2319
SS-Nppbem2Mcwi-/- heart left ventricle weight vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle mass male 252 days 7 1.78 g 0.04 0.11 echocardiography 0.0 0 99814 2319
SD-Nfe2l2em1Mcwi+/+ middle cerebral artery inner diameter controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) then physiological salt solution perfusate Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. cerebral artery size trait male 9 days-11 days 5 145.0 um 12.5 27.95 ex vivo method 0.0 0 resting diameter 100751 2520
SD-Nfe2l2em1Mcwi-/- percent change in middle cerebral artery inner diameter controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) then physiological salt solution perfusate Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. cerebral artery size trait male 9 days-11 days 4 37.4 % 6.53 13.06 ex vivo method 0.0 0 tone 100758 2520
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 4.2 g/kg 0.62 post excision weight measurement 0.0 0 102125 2646
WKY/NHsd plasma cystatin C level controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood cystatin C amount male 0 days 7 3.5 mg/l 0.2 0.53 automated plasma protein analysis 0.0 0 99177 2238
WF/Mol body weight vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 7 186.0 g 2.0 5.29 body weighing method 0.0 acf 4 days 101302 2585
WF/Mol body weight gain vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 5 18.0 g 1.0 2.24 body weighing method 0.0 4 days change from surgery weight 101325 2585
WF/Mol body weight gain vehicle control condition then artificial aortocaval fistula (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 7 -14.0 g 2.0 5.29 body weighing method 0.0 acf 2 days change from surgery weight 101334 2585
SS-Nppbem2Mcwi-/- ejection fraction vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. cardiac output trait male 84 days 7 83.3 % 4.3 11.38 echocardiography 0.0 0 99798 2319
SS.ZUC-Leprfa+/+/Slc systolic blood pressure bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. arterial blood pressure trait female 91 days 9 undefined 138.0 mmHg 1.0 3.0 tail cuff plethysmography 0.0 ovariectomy 42 days 101669 2622
SS.ZUC-Leprfa+/+/Slc heart left ventricle end-diastolic diameter bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle end-diastolic diameter female 91 days 9 7.21 mm 0.21 0.63 echocardiography 0.0 ovariectomy 42 days 101715 2622
SS.ZUC-Leprfa-/-/Slc heart left ventricle end-diastolic diameter bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle end-diastolic diameter female 91 days 8 7.2 mm 0.14 0.4 echocardiography 0.0 ovariectomy 42 days 101717 2622
SS.ZUC-Leprfa+/+/Slc E wave deceleration time bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 9 35.4 ms 1.2 3.6 echocardiography 0.0 ovariectomy 42 days 101731 2622
WKY/Gcrc urine potassium level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine potassium amount male 126 days 18 71.25 mmol/l 33.04 140.18 urine potassium analysis 0.0 0 102142 2646
WKY/NHsd plasma chloride level controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood chloride amount male 0 days 7 104.8 mmol/l 1.8 4.76 automated blood electrolyte analysis 0.0 0 99169 2238
WKY/NHsd urine sodium excretion rate controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. urine sodium amount male 0 days 7 41.9 mEq/d 5.2 13.76 urine sodium analysis 0.0 0 99185 2238
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 8 3.09 ml/min/100g 0.18 0.51 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99951 2378
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 7 0.23 null 0.01 0.03 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99955 2378
SS.ZUC-Leprfa-/-/Slc heart left ventricle fractional shortening vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricle end-diastolic diameter male 91 days 13 47.66 % 2.43 8.76 echocardiography 0.0 0 102007 2644
SS.ZUC-Leprfa-/-/Slc heart left ventricular end-diastolic blood pressure to heart left ventricular end-diastolic diameter ratio vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricular blood pressure trait male 91 days 13 2.1 mmHg/mm 0.13 0.47 vascular transducer tipped catheter 0.0 0 102025 2644
SS/JrHsdMcwi heart right ventricle weight to left ventricle plus septum weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56 days 7 0.25 g/g 0.02 0.05 post excision weight measurement 0.0 0 heart right ventricle weight to left ventricle plus septum weight ratio 106536 3032
SS-Sod3m1Mcwi heart left ventricle weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left ventricle mass male 56 days 10 0.64 g 0.01 0.03 post excision weight measurement 0.0 0 106539 3032
SS-Sod3m1Mcwi right atrium weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56 days 10 0.01 g 0.0 0.0 post excision weight measurement 0.0 0 106563 3032
SS/JrHsdMcwi liver weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56 days 7 10.6 g 0.42 1.11 post excision weight measurement 0.0 0 106574 3032
SS/JrHsdMcwi kidney weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. kidney mass male 56 days 7 2.13 g 0.05 0.13 post excision weight measurement 0.0 0 106578 3032
SS/JrHsdMcwi heart right atrium weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56 days 7 0.06 mg/g 0.01 0.03 post excision weight measurement 0.0 0 106594 3032
SS-Sod3m1Mcwi liver weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56 days 10 40.9 g/kg 0.77 2.43 post excision weight measurement 0.0 0 106603 3032
SD-Abcb1aem1Sage-/- aqueous humor uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. aqueous humor morphology trait male 35 days-49 days 3 55.9 % 13.2 22.86 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106144 3028
SD brain uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. blood-brain barrier morphology trait male 35 days-49 days 3 9.07 % 0.89 1.54 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106156 3028
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count vehicle control condition (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137 days-144 days 5 10.5 null 0.4 0.9 ex vivo light microscopy with histochemistry 0.0 0 nuclei per cell 105462 3016
SS-Sod3m1Mcwi liver weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56 days 10 29.1 mg/mm 0.66 2.09 post excision weight measurement 0.0 0 106631 3032
SS-Sod3m1Mcwi single kidney weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. kidney mass male 56 days 10 0.06 g/cm 0.0 0.0 post excision weight measurement 0.0 0 106635 3032
Hsd:SD mean corpuscular volume vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte size trait female 84 days 10 57.96 fl 1.26 3.98 automated hematology analysis 0 105968 3021
SD-Ahrem2Sage mean corpuscular hemoglobin vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 18.92 pg 0.39 1.23 automated hematology analysis 0 105981 3021
SD serum interleukin-4 level vehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days) Zhuang ZM, et al., Int J Clin Exp Med. 2015 May 15;8(5):6866-77. eCollection 2015. blood interleukin-4 amount not specified 0 days 4 0.14 ug/l 0.01 0.01 enzyme linked immunosorbent assay 0.0 0 error not defined 105411 3015
Crl:CD(SD) retinal outer layer thickness vehicle control condition (0 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59 days-66 days 5 142.2 um 2.68 6.0 optical coherence tomography 0.0 0 optical coherence tomography outer retinal layer 105466 3016
Crl:CD(SD) full retina thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 81 days-88 days 5 177.2 um 6.22 13.9 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 full retina layer 105446 3016
SS-Sod3m1Mcwi heart rate vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart pumping trait male 56 days 8 354.0 beats/min 12.9 36.49 vascular fluid filled catheter 0.0 0 106799 3032
SS-Sod3m1Mcwi diastolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56 days 8 84.2 mmHg 4.96 14.03 vascular fluid filled catheter 0.0 0 106807 3032
SS/JrHsdMcwi mean aortic pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56 days 6 94.4 mmHg 4.27 10.46 vascular fluid filled catheter 0.0 0 Mean aortic pressure 106810 3032
SS-Sod3m1Mcwi mean aortic pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56 days 8 94.5 mmHg 5.02 14.2 vascular fluid filled catheter 0.0 0 Mean aortic pressure 106811 3032
Crl:CD(SD) full retina thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 137 days-144 days 5 191.6 um 7.56 16.9 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 full retina layer 105458 3016
WAG/Nov thymus weight to body weight ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymus mass male 150 days-180 days 10 0.77 mg/g 0.09 0.28 post excision weight measurement 0.0 IP injeciton 1 days saline 107688 3096
WAG/Nov thymocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymocyte quantity male 150 days-180 days 10 1028.62 x10E6/organ 146.62 463.65 isolated cell counting method 0.0 IP injection 1 days 107693 3096
SHRSP/A3N body weight controlled sodium chloride content drinking water (1 %) (for 42 days) and controlled fat content diet (24.5 %) (for 42 days) and vehicle control condition (for 42 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. body mass male 126 days-147 days 0 254.0 g 7.0 body weighing method 0.0 0 107527 3090
SHRSP/A3N both kidneys wet weight to body weight ratio controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney mass male 126 days-182 days 0 13.0 g/kg 0.7 post excision weight measurement kidney 0.0 0 107535 3090
WAG/Nov apoptotic hypodiploid thymocyte count to total thymocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. T cell development trait male 150 days-180 days 10 0.45 % 0.12 0.38 flow cytometry method 0.0 IP injection 1 days saline 107706 3096
SS/NEisSlc creatinine clearance to body weight ratio vehicle control condition (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. glomerular filtration trait not specified 547 days 10 0.38 ml/min/100g 0.03 0.08 plasma creatinine analysis 0.0 0 107441 2339
ISIAH CD3+ splenocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 214.09 x10E6/organ 11.49 36.33 flow cytometry method 0.0 IP injeciton 1 days saline cd3+ spleen 107757 3096
BDIX/CrCrl mean corpuscular hemoglobin concentration DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood hemoglobin amount male 92 days 10 37.0 g/dl 0.19 0.6 blood hemoglobin analysis 0.0 0 hemoglobin, MCH, MCHC 107843 3097
MWF/FubRkb urine albumin excretion rate vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. urine albumin amount male 114 days 10 64.4 mg/d 5.6 17.71 enzyme linked immunosorbent assay 0.0 0 109405 3140
MWF/FubRkb mesenteric artery adventitial thickness vehicle control condition Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. mesenteric artery morphology trait male 114 days 10 8.6 um 0.7 2.21 confocal microscopy 0.0 0 109425 3140
Crl:WI mesenteric artery media thickness vehicle control condition Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. mesenteric artery morphology trait male 114 days 10 18.5 um 0.8 2.53 confocal microscopy 0.0 0 109427 3140
BDIX/CrCrl blood lymphocyte count to total leukocyte count ratio DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. lymphocyte quantity male 71 days 10 8.1 % 0.25 0.8 automated differential white blood cell count test 0.0 0 LYM 107851 3097
BDIX/CrCrl mean corpuscular volume DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. erythrocyte size trait male 92 days 10 47.5 fl 0.19 0.6 automated hematology analysis 0.0 0 MCV, RDW% 107808 3097
BDIX/CrCrl platelet distribution width DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. platelet size trait male 71 days 10 8.7 fl 0.16 0.5 automated hematology analysis 0.0 0 107882 3097
BDIX/CrCrl serum total bilirubin level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood bilirubin amount male 92 days 10 0.35 mg/dl 0.16 0.5 automated serum analysis 0.0 0 serum bilirubin 107926 3097
RCS/LavRrrc scotopic B wave amplitude of ERG waveform vehicle control condition (2 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus Huang L, et al., Stem Cell Res Ther. 2017 Dec 22;8(1):290. doi: 10.1186/s13287-017-0731-y. rod electrophysiology trait not specified 77 days 4 13.01 uV 1.85 3.69 electroretinography retina 0.0 pbs vehicle injection 56 days 109862 3157
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 11 8.7 x 10E3 um2 2.6 8.62 ex vivo light microscopy with histochemistry 0.0 unx 150 days 107510 2378
RCS/LavRrrc scotopic B wave amplitude of ERG waveform vehicle control condition (2 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus Huang L, et al., Stem Cell Res Ther. 2017 Dec 22;8(1):290. doi: 10.1186/s13287-017-0731-y. rod electrophysiology trait not specified 49 days 4 29.44 uV 7.44 14.87 electroretinography retina 0.0 pbs vehicle injection 28 days 109859 3157
BDIX/CrCrl platelet distribution width (percentage) DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. platelet size trait male 71 days 10 5.2 % 0.0 0.0 automated hematology analysis 0.0 0 108146 3097
BDIX/CrCrl platelet distribution width (percentage) DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. platelet size trait male 92 days 10 8.5 % 0.0 0.0 automated hematology analysis 0.0 0 108148 3097
SHRSP/A3N kidney tubule regeneration foci count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 27.3 /section 2.9 ex vivo light microscopy with histochemistry 0.0 0 107547 3090
SS/NEisSlc plasma creatinine level vehicle control condition (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. blood creatinine amount not specified 547 days 10 0.59 mg/dl 0.05 0.16 plasma creatinine analysis 0.0 0 107421 2339
BDIX/CrCrl serum alanine aminotransferase activity level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood alanine transaminase amount male 92 days 10 44.8 U/l 2.94 9.3 automated serum analysis 0.0 0 serum alanine aminotransferase 107909 3097
Hsd:WI kidney catalase activity to total protein level ratio vehicle control condition (for 10 days) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. catalase activity male 0 days 6 35.98 nmol/mg 0.81 1.98 liquid phase colorimetry 0.0 0 76234 1544
BluHsd:LE food intake weight to change in body weight ratio controlled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. eating behavior trait male 71 days-98 days 8 6.7 g/g 0.3 0.85 unspecified method 0.0 0 76203 1543
HanTac:WH body weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. body mass male 16 days-17 days 18 28.6 g 1.08 4.6 body weighing method 0.0 0 96632 1559
Hsd:WI kidney lipid peroxide level vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney lipid peroxide amount male 0 days 6 1.51 nmol/mg 0.03 0.08 liquid phase colorimetry 0.0 0 76257 1544
Hsd:WI liver weight to body weight ratio vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. liver mass male 119 days-126 days 5 34.85 g/kg 1.21 2.7 post excision weight measurement 0.0 0 76095 1545
WKY E/A wave ratio left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. blood flow trait male 238 days-252 days 30 1.85 null 0.14 0.77 echocardiography 0.0 lad occlusion 196 days 100356 2460
WKY timed urine volume left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. urine output male 238 days-252 days 7 10.6 ml/d 2.2 5.82 urine volume measurement method 0.0 lad occlusion 196 days 100362 2460
WKY/Gcrc heart weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart mass male 126 days 0 3.48 g/kg 0.26 post excision weight measurement 0.0 0 102101 2646
SD-Ahrem2Sage blood neutrophil count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. neutrophil quantity female 84 days 10 1.89 x 1000 cells/ul 0.62 1.96 automated hematology analysis 0 106029 3021
Slc:W blood triglyceride level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood triglyceride amount male 105 days 0 119.5 mg/dl 12.4 blood triglyceride analysis 0.0 0 n=4-6 102886 2781
Slc:W blood high density lipoprotein cholesterol level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood HDL cholesterol amount male 105 days 0 4.2 mg/dl 0.3 blood high-density lipoprotein-cholesterol measurement test 0.0 0 n=4-6 102894 2781
SS/JrHsdMcwi lung weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56 days 7 1.23 g 0.05 0.13 post excision weight measurement 0.0 0 106558 3032
SS-Sod3m1Mcwi kidney weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. kidney mass male 56 days 10 2.03 g 0.03 0.09 post excision weight measurement 0.0 0 106579 3032
LH/Mav urine creatinine excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine creatinine amount male 112 days 11 12.9 mg/d 0.4 1.33 urine creatinine analysis 0.0 0 102748 2721
LH/Mav heart left ventricle weight to body weight ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. heart left ventricle mass male 112 days 11 2.24 mg/g 0.0 0.01 post excision weight measurement 0.0 0 102768 2721
LL/Mav creatinine clearance vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. glomerular filtration trait male 112 days 9 1.53 ml/min 0.07 0.21 plasma creatinine analysis 0.0 0 102774 2721
Hsd:SD blood monocyte count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. monocyte quantity female 84 days 10 0.29 x 1000 cells/ul 0.14 0.44 automated hematology analysis 0 106052 3021
SD left ventricular end-diastolic blood pressure sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart left ventricular blood pressure trait male 0 days 6 3.0 mmHg 1.0 2.45 vascular transducer tipped catheter 1.0 sham ACF 2 days 98827 2160
SD left ventricular end-systolic blood pressure artificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart left ventricular blood pressure trait male 0 days 6 56.0 mmHg 3.0 7.35 vascular transducer tipped catheter 1.0 ACF 2 days 98838 2160
SD heart left ventricle weight to body weight ratio sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart left ventricle mass male 0 days 6 g/g*103 2.3 mg/g 0.1 0.24 post excision weight measurement 1.0 sham ACF 2 days 98875 2160
SS-Nppbem2Mcwi-/- heart left ventricle fractional shortening vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-diastolic diameter male 84 days 7 47.3 % 4.1 10.85 echocardiography 0.0 0 99804 2319
LH/Mav body weight vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. body mass male 49 days-56 days 8 232.0 g 6.0 16.97 body weighing method 0.0 0 102642 2703
SS.ZUC-Leprfa+/+/Slc inguinal fat pad weight to tibia length ratio bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. inguinal fat pad mass female 91 days 9 32.0 mg/mm 3.0 9.0 post excision weight measurement 0.0 ovariectomy 42 days sf/tl 101703 2622
Hsd:WI right kidney wet weight vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. kidney mass male 119 days-126 days 5 1.21 g 0.04 0.08 post excision weight measurement 0.0 0 76070 1545
LH/MavRrrc heart left ventricle weight to body weight ratio vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. heart left ventricle mass male 112 days 8 23.0 mg/g 0.2 0.57 post excision weight measurement 0.0 0 102681 2703
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 17 324.0 mg/dl 13.0 53.6 machine read blood glucose test strip 0.0 unx 168 days 99971 2378
WKY renal plasma flow to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney plasma flow trait male 0 days 17 1.72 ml/min/100g 0.11 0.45 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99991 2378
MW body weight unilateral nephrectomy (for 70 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. body mass male 0 days 7 286.0 g 9.0 23.81 body measuring method 0.0 unx 70 days 101154 2581
MW systolic blood pressure unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 7 undefined 118.0 mmHg 2.0 5.29 tail cuff plethysmography 0.0 unx 42 days 101163 2581
SS/NEisSlc urine total protein excretion rate vehicle control condition (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. total urine protein amount not specified 547 days 10 215.9 mg/d 15.3 48.38 urine total protein analysis 0.0 0 107437 2339
GK mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 143.0 mmHg 3.0 7.94 vascular transducer tipped catheter 0.0 0 103034 2784
GK heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 147.0 beats/min 7.0 18.52 vascular transducer tipped catheter 0.0 0 103038 2784
GK heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 5 252.0 beats/min 25.0 55.9 vascular transducer tipped catheter 0.0 0 103053 2784
WF/Mol systolic blood pressure vehicle control condition then artificial aortocaval fistula (for 9 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. arterial blood pressure trait male 0 days 7 undefined 130.0 mmHg 10.0 26.46 tail cuff plethysmography 0.0 acf 9 days 101353 2585
WF/Mol systolic blood pressure vehicle control condition then sham surgical control condition (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. arterial blood pressure trait male 0 days 6 undefined 150.0 mmHg 4.0 9.8 tail cuff plethysmography 0.0 sham acf 2 days 101357 2585
WKY heart left ventricle end-diastolic diameter left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle end-diastolic diameter male 238 days-252 days 30 10.6 mm 0.1 0.55 echocardiography 0.0 lad occlusion 196 days 100341 2460
WF/Mol heart right ventricle weight vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 8 0.07 g 0.0 0.01 post excision weight measurement 0.0 acf 4 days 101426 2585
WF/Mol body weight vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 5 192.0 g 3.0 6.71 body weighing method 0.0 4 days 101317 2585
WKY/NHsd skin chloride level to skin water level ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin chloride amount male 0 days 7 101.0 mmol/l 3.9 10.32 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin na/h2o 99149 2238
WF/Mol heart right ventricle weight vehicle control condition then artificial aortocaval fistula (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 8 0.07 g 0.0 0.0 post excision weight measurement 0.0 acf 2 days 101422 2585
SHRSP/Gcrc urine potassium level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine potassium amount male 126 days 17 44.48 mmol/l 17.37 71.62 urine potassium analysis 0.0 0 102141 2646
HanTac:WH number of male offspring to litter size ratio vehicle control condition (for 14 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. single birth offspring quantity female 0 days 18 50.5 % 4.36 18.5 in vivo visual assessment 0.0 0 (number of males to litter size) ratio) 96607 1559
HanTac:WH body weight vehicle control condition (for 1 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. body mass male 1 days 17 6.2 g 0.12 0.5 body weighing method 0.0 0 96612 1559
BluHsd:LE serum estradiol level vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. blood estradiol amount male 98 days 8 370.0 pg/ml 120.0 339.41 radioimmunoassay 0.0 0 tritium-based 76254 1543
BluHsd:LE body weight vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. body mass male 98 days 8 457.7 g 15.9 44.97 body weighing method 0.0 0 75962 1543
Hsd:WI body weight vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. body mass male 119 days-126 days 5 388.0 g 16.82 37.6 body weighing method 0.0 0 76041 1545
HanTac:WH right testis wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. testis mass male 16 days-17 days 18 51.3 mg 1.79 7.6 post excision weight measurement 0.0 0 96637 1559
HanTac:WH bulbourethral gland wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. bulbourethral gland mass male 16 days-17 days 18 1.7 mg 0.09 0.4 post excision weight measurement 0.0 0 96667 1559
Hsd:WI left kidney wet weight vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. kidney mass male 119 days-126 days 5 1.19 g 0.06 0.13 post excision weight measurement 0.0 0 76075 1545
HanTac:WH liver wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. liver mass female 16 days-17 days 15 0.8 g 0.02 0.07 post excision weight measurement 0.0 0 96702 1559
SD mean arterial blood pressure sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. arterial blood pressure trait male 0 days 6 86.0 mmHg 4.0 9.8 vascular transducer tipped catheter 1.0 sham ACF 2 days 98815 2160
WKY/Gcrc heart left ventricle weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart left ventricle mass male 126 days 0 2.52 mg/g 0.2 post excision weight measurement 0.0 0 102110 2646
SHRSP.WKY-(D3Wox20-D3Rat114)/Gcrc heart left ventricle weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart left ventricle mass male 126 days 6 3.33 mg/g 0.33 0.81 post excision weight measurement 0.0 0 102112 2646
SHRSP.WKY-(D3Mgh16-D3Rat80)/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 3.77 g/kg 0.12 post excision weight measurement 0.0 0 102122 2646
SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 4.16 g/kg 0.4 post excision weight measurement 0.0 0 102123 2646
SS/NEisSlc serum creatinine level controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. blood creatinine amount male 126 days 8 0.47 mg/dl 0.04 0.11 serum creatinine analysis 0.0 0 102326 2684
LH/Mav systolic blood pressure vehicle control condition Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. arterial blood pressure trait male 63 days 8 undefined 160.0 mmHg 3.0 8.49 tail cuff plethysmography 0.0 0 102848 2761
GK/Slc blood hemoglobin A1c level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood hemoglobin amount male 105 days 0 5.21 % 0.12 blood hemoglobin analysis 0.0 0 HbA1c n=4-6 102880 2781
Slc:W blood low density lipoprotein cholesterol level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood LDL cholesterol amount male 105 days 0 26.8 mg/dl 1.4 blood low-density lipoprotein-cholesterol measurement test 0.0 0 n=4-6 102898 2781
LH/Mav blood glucose level vehicle control condition then fasting (for 16 hours) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood glucose amount male 56 days 11 69.0 mg/dl 1.0 3.32 blood glucose analysis 0.0 0 102716 2721
LH/Mav urine total protein excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. total urine protein amount male 112 days 11 135.0 mg/d 21.0 69.65 urine protein analysis 0.0 0 102736 2721
LL/Mav urine albumin excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 9 4.4 mg/d 0.3 0.9 urine albumin analysis 0.0 0 102738 2721
LL/Mav body weight vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. body mass male 56 days 9 231.0 g 4.0 12.0 body weighing method 0.0 0 102698 2721
SD body weight controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. body mass female 0 days 13 283.6 g 3.8 13.7 body weighing method 0.0 unx 97 days 100632 2499
SS-Nppbem2Mcwi-/- heart interventricular end-systolic septal wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart ventricle septum thickness male 252 days 7 3.48 mm 0.26 0.69 echocardiography 0.0 0 99784 2319
SS-Nppbem2Mcwi-/- heart left ventricle end-systolic diameter vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-systolic diameter male 168 days 7 4.83 mm 0.35 0.93 echocardiography 0.0 0 99788 2319
Crlj:WI mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 128.0 mmHg 9.0 23.81 vascular transducer tipped catheter 0.0 0 103016 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 96.0 mmHg 8.0 21.17 vascular transducer tipped catheter 0.0 0 103020 2784
GK mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 5 undefined 108.0 mmHg 8.0 17.89 vascular transducer tipped catheter 0.0 0 103021 2784
GK mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 123.0 mmHg 5.0 13.23 vascular transducer tipped catheter 0.0 0 103026 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) then meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 6 undefined 155.0 mmHg 10.0 24.49 vascular transducer tipped catheter 0.0 0 103027 2784
GK mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 5 undefined 151.0 mmHg 1.0 2.24 vascular transducer tipped catheter 0.0 0 103029 2784
GK mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 140.0 mmHg 8.0 21.17 vascular transducer tipped catheter 0.0 0 103030 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 102.0 mmHg 11.0 29.1 vascular transducer tipped catheter 0.0 0 103032 2784
GK mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 5 undefined 137.0 mmHg 3.0 6.71 vascular transducer tipped catheter 0.0 0 103033 2784
Crlj:WI heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 384.0 beats/min 17.0 44.98 vascular transducer tipped catheter 0.0 0 103044 2784
GK heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 5 301.0 beats/min 21.0 46.96 vascular transducer tipped catheter 0.0 0 103049 2784
GK heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 279.0 beats/min 17.0 44.98 vascular transducer tipped catheter 0.0 0 103054 2784
WF/Mol heart left ventricle weight vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart left ventricle mass male 0 days 7 0.28 g 0.0 0.01 post excision weight measurement 0.0 acf 4 days 101390 2585
WF/Mol heart left ventricle weight vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart left ventricle mass male 0 days 7 0.3 g 0.01 0.02 post excision weight measurement 0.0 acf 7 days 101394 2585
SD left ventricular end-systolic blood pressure sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart left ventricular blood pressure trait male 0 days 6 64.0 mmHg 3.0 7.35 vascular transducer tipped catheter 1.0 sham ACF 2 days 98839 2160
WKY/NCrl diastolic blood pressure vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 89.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks nighttime measurement 103550 2827
WKY/NCrl heart rate vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 168 days 6 294.0 beats/min 5.0 12.25 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103558 2827
WKY/NCrl number of spontaneous locomotor movements per unit time vehicle control condition (between 1 and 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. voluntary movement trait male 168 days 6 0.9 /min 0.1 0.24 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks number of spontaneous locomotor movements per unit time (CMO:0003644) 103574 2827
GK number of spontaneous locomotor movements per unit time vehicle control condition (between 1 and 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. voluntary movement trait male 168 days 6 0.9 /min 0.1 0.24 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks number of spontaneous locomotor movements per unit time (CMO:0003644) 103576 2827
SS-Nppbem2Mcwi-/- body weight vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. body mass male 168 days 7 425.0 g 22.0 58.21 body weighing method 0.0 0 99758 2319
SS-Nppbem2Mcwi-/- body weight vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. body mass male 252 days 7 452.0 g 21.0 55.56 body weighing method 0.0 0 99760 2319
MW body weight unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. body mass male 0 days 7 260.0 g 6.0 15.87 body measuring method 0.0 unx 42 days 101146 2581
MW systolic blood pressure unilateral nephrectomy (for 70 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 7 undefined 122.0 mmHg 2.0 5.29 tail cuff plethysmography 0.0 unx 70 days 101168 2581
MW urine total protein excretion rate vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. total urine protein amount male 0 days 18 8.0 mg/d 2.0 8.49 Bradford protein assay 0.0 control 29 days 101203 2581
WKY/NCrl body weight vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. body mass male 168 days 6 463.0 g 7.0 17.15 body weighing method 0.0 0 103490 2827
GK water intake drink rate to body weight ratio vehicle control condition (between 1 and 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. drinking behavior trait male 140 days-175 days 6 99.0 ml/d/kg 13.0 31.84 drink intake measuring method 0 103500 2827
GK blood glucose level vehicle control condition (for 28 days) then fasting (for 16 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood glucose amount male 168 days 6 122.0 mg/dl 8.0 19.6 blood glucose test strip read by electrochemical glucometer 0.0 0 103512 2827
WF/Mol heart rate vehicle control condition then artificial aortocaval fistula (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 5 470.0 beats/min 12.0 26.83 tail cuff plethysmography 0.0 acf 2 days 101378 2585
WKY hematocrit unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. erythrocyte quantity male 0 days 17 44.8 % 0.6 2.47 hematocrit analysis 0.0 unx 168 days 99976 2378
WF/Mol systolic blood pressure vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. arterial blood pressure trait male 0 days 5 undefined 160.0 mmHg 4.0 8.94 tail cuff plethysmography 0.0 sham acf 4 days 101361 2585
WF/Mol systolic blood pressure vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. arterial blood pressure trait male 0 days 6 undefined 123.0 mmHg 3.0 7.35 tail cuff plethysmography 0.0 acf 7 days 101364 2585
WF/Mol heart rate vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 7 450.0 beats/min 13.0 34.39 tail cuff plethysmography 0.0 acf 7 days 101372 2585
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -8.06 null 0.05 0.13 wire myography 0.0 0 103594 2827
WKY/NCrl aorta wall phosphorylated eNOS level to total eNOS level ratio vehicle control condition (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. artery molecular composition trait male 175 days 7 1.45 null 0.21 0.56 western blot assay 0.0 0 103618 2827
WI neuron rough endoplasmic reticulum area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 27.4 % 0.51 1.02 ex vivo electron microscopy with digital image analysis 0.0 0 rer/cyto 103653 2844
OXYS/Nov neuron rough endoplasmic reticulum area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 11.2 % 0.33 0.66 ex vivo electron microscopy with digital image analysis 0.0 0 rer/cyto 103654 2844
SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc urine urea level to urine creatinine level ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 9 87.33 null 12.81 38.43 urine urea analysis 0.0 0 103793 2646
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc urine urea level to urine creatinine level ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 6 76.34 null 4.14 10.14 urine urea analysis 0.0 0 103795 2646
SS/NEisSlc systolic blood pressure controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. arterial blood pressure trait male 126 days 8 undefined 226.0 mmHg 11.0 31.11 tail cuff plethysmography 0.0 0 102314 2684
LL/Mav aorta weight to body weight ratio vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. aorta mass male 112 days 13 11.6 mg/100g 0.3 1.08 post excision weight measurement 0.0 0 102686 2703
SS.ZUC-Leprfa-/-/Slc heart left ventricle weight to tibia length ratio vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricle mass male 91 days 13 0.31 g/cm 0.01 0.03 post excision weight measurement 0.0 0 lv/tl 101977 2644
SS.ZUC-Leprfa-/-/Slc inguinal fat pad weight to tibia length ratio vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. inguinal fat pad mass male 91 days 13 1501.32 mg/mm 68.53 247.09 post excision weight measurement 0.0 0 if/tl 101989 2644
WKY kidney fibrotic lesion area to total kidney area ratio left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. kidney integrity trait male 238 days-252 days 15 0.75 % 0.13 0.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 lad occlusion 196 days 100385 2460
LL/Mav blood glucose level vehicle control condition then fasting (for 16 hours) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood glucose amount male 56 days 9 70.0 mg/dl 1.0 3.0 blood glucose analysis 0.0 0 102714 2721
SS-Nppbem2Mcwi-/- diastolic blood pressure vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. arterial blood pressure trait male 84 days 7 serial mean 128.0 mmHg 22.0 58.21 tail cuff plethysmography 0.0 0 99822 2319
SS-Nppbem2Mcwi-/- diastolic blood pressure vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. arterial blood pressure trait male 252 days 7 serial mean 145.0 mmHg 31.0 82.02 tail cuff plethysmography 0.0 0 99826 2319
SS-Nppbem2Mcwi-/- systolic blood pressure vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. arterial blood pressure trait male 168 days 7 serial mean 195.0 mmHg 30.0 79.37 tail cuff plethysmography 0.0 0 99830 2319
SS-Nppbem2Mcwi-/- timed urine volume vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. urine output male 84 days 7 14.7 ml/d 2.6 6.88 urine volume measurement method 0.0 0 99840 2319
SS-Nppbem2Mcwi-/- timed urine volume vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. urine output male 168 days 7 21.1 ml/d 7.6 20.11 urine volume measurement method 0.0 0 99842 2319
WKY/NHsd skin chloride level to skin dry weight ratio standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin chloride amount male 0 days 7 0.05 mmol/g 0.0 0.01 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin cl mmol/g 99135 2238
WKY/NHsd skin chloride level to skin dry weight ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin chloride amount male 0 days 7 0.07 mmol/g 0.01 0.02 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin cl mmol/g 99137 2238
WKY/NHsd plasma sodium level standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood sodium amount male 0 days 7 143.7 mmol/l 4.4 11.64 automated blood electrolyte analysis 0.0 0 99159 2238
WKY/NHsd plasma creatinine level controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood creatinine amount male 0 days 7 0.3 mg/dl 0.01 0.02 plasma creatinine analysis 0.0 0 99173 2238
SHRSP/Gcrc water drink intake rate vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. drinking behavior trait male 126 days 17 78.62 ml/d 21.79 89.84 metabolic cage water drinking measurement method 0.0 0 102126 2646
WF/Mol body weight gain vehicle control condition then artificial aortocaval fistula (for 9 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 7 29.0 g 3.0 7.94 body weighing method 0.0 acf 9 days change from surgery weight 101331 2585
SS.ZUC-Leprfa-/-/Slc tibia straight segment length bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. tibia length female 91 days 8 32.5 mm 0.9 2.55 body length measuring method 0.0 ovariectomy 42 days 101667 2622
SS.ZUC-Leprfa+/+/Slc heart rate bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 9 380.0 beats/min 8.0 24.0 tail cuff plethysmography 0.0 ovariectomy 42 days 101673 2622
SS.ZUC-Leprfa-/-/Slc calculated heart left ventricle weight bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle mass female 91 days 8 1114.0 mg 35.0 98.99 echocardiography 0.0 ovariectomy 42 days 101725 2622
SS.ZUC-Leprfa-/-/Slc heart isovolumetric relaxation time bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart muscle relaxation trait female 91 days 8 43.1 ms 1.5 4.24 echocardiography 0.0 ovariectomy 42 days 101737 2622
SS.ZUC-Leprfa-/-/Slc time constant of left ventricular pressure decay bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricular blood pressure trait female 91 days 8 47.3 ms 1.5 4.24 echocardiography 0.0 ovariectomy 42 days 101749 2622
MWF/ZtmRrrc body weight vehicle control condition Remuzzi A, et al., J Clin Invest. 1990 Feb;85(2):541-9. body mass male 126 days 8 378.0 g 10.61 30.0 body weighing method 0.0 0 100901 2541
WF/Mol body weight vehicle control condition then sham surgical control condition (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 6 200.0 g 2.0 4.9 body weighing method 0.0 2 days 101313 2585
WF/Mol body weight vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 8 193.0 g 2.0 5.66 body weighing method 0.0 acf 7 days 101320 2585
WKY body weight unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 8 215.0 g 10.0 28.28 body weighing method 0.0 unx 28 days 99936 2378
SHRSP/Gcrc urine sodium level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine sodium amount male 126 days 17 211.14 mmol/l 46.41 191.35 urine sodium analysis 0.0 0 102136 2646
WKY/Gcrc urine sodium level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine sodium amount male 126 days 18 220.23 mmol/l 71.19 302.03 urine sodium analysis 0.0 0 102137 2646
SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc urine sodium level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine sodium amount male 126 days 7 260.49 mmol/l 36.69 97.07 urine sodium analysis 0.0 0 102139 2646
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc urine urea level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 6 103.0 mmol/l 34.23 83.85 urine urea analysis 0.0 0 102150 2646
SHRSP/Gcrc urine creatinine level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine creatinine amount male 126 days 17 6.85 mg/dl 2.77 11.4 urine creatinine analysis 0.0 0 102151 2646
SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc urine creatinine level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine creatinine amount male 126 days 7 12.38 mg/dl 3.61 9.54 urine creatinine analysis 0.0 0 102154 2646
WKY/NHsd mean arterial blood pressure controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. arterial blood pressure trait male 0 days 7 116.0 mmHg 1.0 2.65 intra-aortic radiotelemetry 0.0 0 99189 2238
WKY heart left ventricle end-systolic diameter left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle end-systolic diameter male 238 days-252 days 30 8.9 mm 0.2 1.1 echocardiography 0.0 lad occlusion 196 days 100344 2460
SS.ZUC-Leprfa-/-/Slc serum total cholesterol level vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood cholesterol amount male 91 days 6 333.0 mg/dl 15.6 38.21 serum total cholesterol measurement test 0.0 0 101941 2644
SS.ZUC-Leprfa-/-/Slc serum high density lipoprotein cholesterol level vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood HDL cholesterol amount male 91 days 6 97.25 mg/dl 15.33 37.55 serum high-density lipoprotein-cholesterol measurement test 0.0 0 101947 2644
SS.ZUC-Leprfa-/-/Slc serum triglyceride level vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood triglyceride amount male 91 days 6 2196.13 mg/dl 204.52 500.97 serum triglyceride analysis 0.0 0 101950 2644
SHRSP/Gcrc heart weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart mass male 126 days 0 4.66 g/kg 0.4 post excision weight measurement 0.0 0 102100 2646
SD-Nfe2l2em1Mcwi+/+ body weight controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. body mass male 9 days-11 days 8 281.0 g 17.7 50.06 body weighing method 0.0 0 100733 2520
SS-Sod3m1Mcwi heart left ventricle weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left ventricle mass male 56 days 10 2.49 mg/g 0.03 0.09 post excision weight measurement 0.0 0 106587 3032
SS/JrHsdMcwi lung weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56 days 7 0.4 % 0.08 0.2 post excision weight measurement 0.0 0 106590 3032
SS-Sod3m1Mcwi heart right ventricle weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56 days 10 4.33 mg/mm 0.97 3.07 post excision weight measurement 0.0 0 106611 3032
F344-Pde4dTn(sb-T2/Bart3)2.285Mcwi cerebrum infarct volume to total cerebrum volume ratio isoflurane (1.5 %) (for 4 hours) then vehicle control condition then middle cerebral artery occlusion (for 1 hours) Yang F, et al., J Pharm Pharm Sci. 2014;17(3):362-70. cerebrum integrity trait male 0 days 6 20.0 % 9.0 22.05 ex vivo light microscopy with histochemistry and digital image analysis 0.0 cerebral ischemia 1 days 106360 3029
SD-Abcb1aem1Sage-/- retinal uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina blood vessel morphology trait male 42 days-56 days 3 88.0 % 29.7 51.44 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106126 3028
SS/JrHsdMcwi heart left ventricle weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left ventricle mass male 56 days 7 0.64 g 0.02 0.05 post excision weight measurement 0.0 0 106538 3032
SS-Sod3m1Mcwi body weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. body mass male 56 days 10 259.0 g 2.8 8.85 body weighing method 0.0 0 106551 3032
SS-Sod3m1Mcwi lung weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56 days 10 1.2 g 0.01 0.03 post excision weight measurement 0.0 0 106559 3032
SS/JrHsdMcwi right atrium weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56 days 7 0.02 g 0.0 0.0 post excision weight measurement 0.0 0 106562 3032
SD-Ahrem2Sage blood eosinophil count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. eosinophil quantity female 84 days 10 0.18 x 1000 cells/ul 0.18 0.57 automated hematology analysis 0 106065 3021
Hsd:SD brain weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. brain mass female 84 days 10 0.74 % 0.03 0.1 post excision weight measurement 0 105908 3021
SS/JrHsdMcwi heart right atrium weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56 days 7 0.44 mg/mm 0.04 0.1 post excision weight measurement 0.0 0 106622 3032
SS/JrHsdMcwi single kidney weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. kidney mass male 56 days 7 0.06 g/cm 0.0 0.0 post excision weight measurement 0.0 0 106634 3032
SS-Sod3m1Mcwi systolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56 days 8 115.0 mmHg 5.22 14.76 vascular fluid filled catheter 0.0 0 106803 3032
SS/NEisSlc systolic blood pressure vehicle control condition (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. arterial blood pressure trait not specified 547 days 10 137.0 mmHg 3.0 9.49 vascular indwelling catheter method femoral artery 0.0 0 106791 2339
Hsd:SD blood hemoglobin level vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 14.05 g/dl 0.48 1.52 automated hematology analysis 0 105944 3021
SD-Ahrem2Sage mean corpuscular volume vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte size trait female 84 days 10 58.44 fl 0.87 2.75 automated hematology analysis 0 105969 3021
Hsd:SD mean corpuscular hemoglobin concentration vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 32.48 g/dl 0.68 2.15 automated hematology analysis 0 105992 3021
SD-Ahrem2Sage mean corpuscular hemoglobin concentration vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 32.37 g/dl 0.7 2.21 automated hematology analysis 0 105993 3021
SD serum interleukin-9 level vehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days) Zhuang ZM, et al., Int J Clin Exp Med. 2015 May 15;8(5):6866-77. eCollection 2015. blood interleukin-9 amount not specified 0 days 4 0.1 ug/l 0.01 0.01 enzyme linked immunosorbent assay 0.0 0 error not defined 105415 3015
SD intestine trypsin level vehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days) Zhuang ZM, et al., Int J Clin Exp Med. 2015 May 15;8(5):6866-77. eCollection 2015. intestine trypsin amount not specified 0 days 4 0.17 ug/l 0.01 0.01 enzyme linked immunosorbent assay 0.0 0 error not defined 105419 3015
Crl:CD(SD) retinal outer nuclear layer thickness vehicle control condition (0 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 59 days-66 days 5 41.0 um 1.12 2.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 outer nuc layer 105434 3016
Crl:CD(SD) retinal outer nuclear layer thickness vehicle control condition (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137 days-144 days 5 50.6 um 1.61 3.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 outer nuc layer 105454 3016
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59 days-66 days 5 131.6 um 4.87 10.9 optical coherence tomography 0.0 0 optical coherence tomography inner retinal layer 105470 3016
SHRSP/A3NCrl systolic blood pressure controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. arterial blood pressure trait male 161 days-175 days 6 162.0 mmHg 4.0 9.8 tail cuff plethysmography 0.0 0 107385 3083
WAG/Nov G0 stage diploid thymocyte count to total thymocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. T cell development trait male 150 days-180 days 10 93.31 % 0.93 2.94 flow cytometry method 0.0 IP injection 1 days saline 107709 3096
WAG/Nov G2/M stage tetraploid thymocyte count to total thymocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. T cell development trait male 150 days-180 days 10 2.62 % 0.29 0.92 flow cytometry method 0.0 IP injeciton 1 days saline 107712 3096
Crl:WI urine albumin excretion rate vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. urine albumin amount male 114 days 10 0.17 mg/d 0.01 0.03 enzyme linked immunosorbent assay 0.0 0 109403 3140
Crl:WI heart rate vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. heart pumping trait male 112 days 10 355.3 beats/min 9.7 30.67 tail cuff plethysmography heart 0.0 0 109411 3140
MWF/FubRkb heart rate vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. heart pumping trait male 112 days 10 352.3 beats/min 7.3 23.08 tail cuff plethysmography heart 0.0 0 109413 3140
Crl:WI pulse wave velocity vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. arterial blood pressure trait male 112 days 10 5.4 /ms 0.5 1.58 tail cuff plethysmography 0.0 0 109415 3140
MWF/FubRkb pulse wave velocity vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. arterial blood pressure trait male 112 days 10 5.6 /ms 0.5 1.58 tail cuff plethysmography 0.0 0 109417 3140
MWF/FubRkb mesenteric artery wall thickness vehicle control condition Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. mesenteric artery morphology trait male 114 days 10 36.3 um 1.1 3.48 confocal microscopy 0.0 0 109421 3140
Crl:WI mesenteric artery adventitial thickness vehicle control condition Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. mesenteric artery morphology trait male 114 days 10 8.2 um 0.7 2.21 confocal microscopy 0.0 0 109423 3140
MWF/FubRkb mesenteric artery media thickness vehicle control condition Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. mesenteric artery morphology trait male 114 days 10 19.6 um 0.7 2.21 confocal microscopy 0.0 0 109429 3140
WAG/Nov CD4+CD8+ thymocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymocyte quantity male 150 days-180 days 10 596.53 x10E6/organ 88.59 280.15 flow cytometry method 0.0 IP injeciton 1 days saline cd4+cd8+ t-cell 107721 3096
WAG/Nov CD4+CD25- splenocyte count to total splenocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 27.9 % 0.69 2.18 flow cytometry method 0.0 IP injeciton 1 days saline cd4+cd25- spleen 107730 3096
WAG/Nov CD11b/c+ splenocyte count to total splenocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 12.4 % 0.81 2.56 flow cytometry method 0.0 IP injeciton 1 days saline cd11b/c+ spleen 107736 3096
WAG/Nov CD11b/c+ splenocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 92.63 x10E6/organ 24.28 76.78 flow cytometry method 0.0 IP injeciton 1 days saline cd11b/c+ spleen 107739 3096
ISIAH CD4-CD25+ splenocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 3.21 x 10E6/organ 0.57 1.8 flow cytometry method 0.0 IP injeciton 1 days saline cd4-cd25+ spleen 107754 3096
WAG/Nov plasma total cholesterol level vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. blood cholesterol amount male 150 days-180 days 10 74.4 mg/dl 4.1 12.97 plasma total cholesterol measurement test 0.0 IP injeciton 1 days saline 107781 3096
BDIX/CrCrl mean platelet volume DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. platelet size trait male 71 days 10 5.9 fl 0.03 0.1 automated hematology analysis 0.0 0 107821 3097
BDIX/CrCrl mean platelet volume DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. platelet size trait male 92 days 10 5.9 fl 0.06 0.2 automated hematology analysis 0.0 0 107823 3097
BDIX/CrCrl total white blood cell count DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. leukocyte quantity male 92 days 10 10.0 x 1000 cells/ul 0.35 1.1 automated total white blood cell count test 0.0 0 WBC 107828 3097
BDIX/CrCrl mean corpuscular hemoglobin DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood hemoglobin amount male 92 days 10 17.5 pg 0.03 0.1 blood hemoglobin analysis 0.0 0 hemoglobin, MCH, MCHC 107838 3097
BDIX/CrCrl mean corpuscular hemoglobin concentration DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood hemoglobin amount male 71 days 10 38.0 g/dl 0.13 0.4 blood hemoglobin analysis 0.0 0 hemoglobin, MCH, MCHC 107841 3097
BDIX/CrCrl red blood cell distribution width-coefficient of variation DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. erythrocyte size trait male 71 days 10 16.9 % 0.22 0.7 automated hematology analysis 0.0 0 MCV, RDW% 107846 3097
BDIX/CrCrl serum total cholesterol level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood cholesterol amount male 71 days 10 60.0 mg/dl 2.21 7.0 automated serum analysis 0.0 0 serum total cholesterol 107892 3097
BDIX/CrCrl serum amylase activity level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood amylase amount male 71 days 10 3096.0 U/l 32.26 102.0 automated serum analysis 0.0 0 serum amylase 107944 3097
BDIX/CrCrl platelet distribution width DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. platelet size trait male 92 days 10 8.6 fl 0.03 0.1 automated hematology analysis 0.0 0 107884 3097
BDIX/CrCrl red blood cell count DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. erythrocyte quantity male 92 days 10 10.7 x 10E6 cells/ul 0.25 0.8 automated blood cell counting method 0.0 0 red blood cell count, hematocrit 107803 3097
Hsd:SD photopic B wave amplitude of ERG waveform vehicle control condition (2 ul) then controlled visible light condition (30 cd x s/m2) then visible light stimulus (12 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. cone electrophysiology trait both 0 days 4 51.0 uV electroretinography cornea 0.0 subretinal injection 30 days photopic b-wave ERG 108644 3128
SS/NEisSlc time to first movement outside a discrete space in an experimental apparatus vehicle control condition (for 547.5 days) then tactile electric shock exposure (500 mA) (for 0 hours) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. locomotor behavior trait not specified 63 days-236 days 10 235.0 s 50.0 158.11 passive avoidance test using a two-way shuttle box apparatus 0.0 electric foot shock 18 days passive avoidance test using a two-way shuttle box apparatus (MMO:000072) 107468 2339
SS/NEisSlc serum NAG activity level vehicle control condition (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. blood enzyme amount not specified 547 days 10 20.1 uU/ml 1.9 6.01 blood NAG activity assay 0.0 0 blood NAG activity assay (MMO:0000723) serum NAG activity level (CMO:0003487) 107425 2339
SHRSP/A3N systolic blood pressure controlled sodium chloride content drinking water (1 %) (for 84 days) and controlled fat content diet (24.5 %) (for 84 days) and vehicle control condition (for 84 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. arterial blood pressure trait male 168 days-189 days 6 serial mean 284.0 mmHg 8.0 19.6 tail cuff plethysmography tail 0.0 0 average 3 week intervals for 12 weeks 107499 3090
BDIX/CrCrl serum aspartate aminotransferase activity level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood aspartate transaminase amount male 71 days 10 139.0 U/l 2.59 8.2 automated serum analysis 0.0 0 serum aspartate aminotransferase 107902 3097
BDIX/CrCrl blood granulocyte count to total leukocyte count ratio DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. granulocyte quantity male 71 days 10 1.2 % 0.0 0.0 automated differential white blood cell count test 0.0 0 107856 3097
WAG body weight CC531 cells (5 X 10E6) (for 21 days) then vehicle control condition (1 ml) (for 21 days) Pross M, et al., Surg Endosc. 2001 Aug;15(8):882-5. doi: 10.1007/s004640090029. Epub 2001 May 2. body mass male 0 days 16 272.4 g 3.35 13.4 body weighing method 0.0 IP injection 21 days cells and vehicle injected 107872 3098
BDIX/CrCrl serum total cholesterol level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood cholesterol amount male 92 days 10 40.5 mg/dl 1.71 5.4 automated serum analysis 0.0 0 serum total cholesterol 107894 3097
SHRSP/A3NCrl ratio of survivors of severe albuminuria to total study population during a period of time controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. life span trait male 161 days-175 days 12 50.0 % unspecified method 0.0 0 ratio of survivors of severe albuminuria to total study population during a period of time (CMO:0003630) 109030 3083
Hsd:WI serum creatinine level vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. blood creatinine amount male 119 days-126 days 5 0.68 mg/dl 0.05 0.11 liquid phase colorimetry 0.0 0 76170 1545
Hsd:WI kidney glutathione level vehicle control condition (for 10 days) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney glutathione amount male 0 days 6 12385.0 ug/g 257.2 630.01 liquid phase colorimetry 0.0 0 76238 1544
HanTac:WH gestation period length vehicle control condition (for 14 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. gestation period duration female 0 days 18 23.0 d 0.14 0.6 in vivo visual assessment 0.0 0 96583 1559
WKY heart left ventricle fractional shortening left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle end-diastolic diameter male 238 days-252 days 30 15.8 % 0.7 3.83 echocardiography 0.0 lad occlusion 196 days 100350 2460
F344 cerebrum infarct volume to total cerebrum volume ratio isoflurane (1.5 %) (for 4 hours) then vehicle control condition then middle cerebral artery occlusion (for 1 hours) Yang F, et al., J Pharm Pharm Sci. 2014;17(3):362-70. cerebrum integrity trait male 0 days 18 11.0 % 2.0 8.49 ex vivo light microscopy with histochemistry and digital image analysis 0.0 cerebral ischemia 1 days 106172 3029
LL/Mav plasma triglyceride level vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood triglyceride amount male 112 days 9 1.4 mmol/l 0.11 0.33 plasma triglyceride analysis 0.0 0 102754 2721
LL/Mav both kidneys wet weight to body weight ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. kidney mass male 112 days 9 6.08 g/kg 0.07 0.21 post excision weight measurement 0.0 0 102762 2721
LH/Mav creatinine clearance vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. glomerular filtration trait male 112 days 11 1.6 ml/min 0.1 0.33 plasma creatinine analysis 0.0 0 102776 2721
Crl:CD(SD) retinal outer layer thickness vehicle control condition (0 mg/kg) (for 26 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 80 days-87 days 10 136.0 um 3.49 7.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography outer retinal layer 105482 3016
SD-Ahrem2Sage white blood cell count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. leukocyte quantity female 84 days 10 10.8 x 1000 cells/ul 1.5 4.74 automated hematology analysis 0 106017 3021
WI cerebrum infarct volume to total cerebrum volume ratio isoflurane (1.5 %) (for 4 hours) then vehicle control condition then embolism injection of middle cerebral artery (for 1 days) Yang F, et al., J Pharm Pharm Sci. 2014;17(3):362-70. cerebrum integrity trait male 0 days 16 23.0 % 3.0 12.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 cerebral ischemia 1 days 106358 3029
SS/JrHsdMcwi liver weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56 days 7 40.5 g/kg 1.02 2.7 post excision weight measurement 0.0 0 106602 3032
SS-Sod3m1Mcwi single kidney wet weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. kidney mass male 56 days 10 7.83 g/kg 0.15 0.47 post excision weight measurement 0.0 0 106607 3032
SS-Nppbem2Mcwi-/- heart left ventricle end-diastolic posterior wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle posterior wall thickness male 252 days 7 2.17 mm 1.94 5.13 echocardiography 0.0 0 99778 2319
GK heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 5 366.0 beats/min 17.0 38.01 vascular transducer tipped catheter 0.0 0 103041 2784
Crlj:WI heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 6 351.0 beats/min 19.0 46.54 vascular transducer tipped catheter 0.0 0 103043 2784
Crlj:WI heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 287.0 beats/min 7.0 18.52 vascular transducer tipped catheter 0.0 0 103048 2784
GK heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 344.0 beats/min 11.0 29.1 vascular transducer tipped catheter 0.0 0 103050 2784
WKY/Izm absolute change in mean arterial blood pressure vehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) then phenylephrine (3 ug) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 50.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84570 1120
SS.ZUC-Leprfa-/-/Slc heart left ventricle end-diastolic diameter vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricle end-diastolic diameter male 91 days 13 8.27 mm 0.13 0.47 echocardiography 0.0 0 101995 2644
LH/Mav timed urine volume vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine output male 56 days 11 8.7 ml/d 0.3 0.99 urine volume measurement method 0.0 0 102708 2721
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 17 0.29 null 0.01 0.05 inulin analysis by liquid phase colorimetry 0.0 unx 168 days 99986 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 11 6.3 mmHg/ml/min 0.4 1.33 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 168 days 99995 2378
GK mesenteric artery phosphorylated eNOS level to total eNOS level ratio vehicle control condition (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. artery molecular composition trait male 175 days 8 0.9 null 0.07 0.2 western blot assay 0.0 0 103624 2827
MW urine total protein excretion rate unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. total urine protein amount male 0 days 7 11.0 mg/d 2.0 5.29 Bradford protein assay 0.0 unx 14 days 101192 2581
GK body weight vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. body mass male 168 days 6 380.0 g 7.0 17.15 body weighing method 0.0 0 103492 2827
WF/Mol heart left ventricle weight vehicle control condition then artificial aortocaval fistula (for 9 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart left ventricle mass male 0 days 7 0.29 g 0.01 0.02 post excision weight measurement 0.0 acf 9 days 101397 2585
LL/Mav systolic blood pressure vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. arterial blood pressure trait male 49 days-56 days 13 undefined 115.0 mmHg 3.0 10.82 tail cuff plethysmography 0.0 0 102644 2703
LH/Mav timed urine volume vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. urine output male 49 days-56 days 8 8.7 ml/d 0.6 1.7 urine volume measurement method 0.0 0 102648 2703
SD maximum rate of positive change in left ventricular blood pressure artificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart left ventricular blood pressure trait male 0 days 6 8259.0 mmHg/s 325.0 796.08 vascular transducer tipped catheter 1.0 ACF 2 days 98886 2160
WF/Mol body weight gain vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 5 6.0 g 1.0 2.24 body weighing method 0.0 sham acf 4 days change from surgery weight 101339 2585
SS.ZUC-Leprfa-/-/Slc left ventricular end-diastolic blood pressure bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricular blood pressure trait female 91 days 8 4.43 mmHg 0.21 0.59 vascular transducer tipped catheter 0.0 ovariectomy 42 days 101745 2622
WKY/Gcrc timed urine volume vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine output male 126 days 18 31.8 ml/d 14.34 60.84 metabolic cage urine volume measurement method 0.0 0 102132 2646
SD maximum rate of negative change in left ventricular blood pressure sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart left ventricular blood pressure trait male 0 days 6 -7197.0 mmHg/s 303.0 742.2 vascular transducer tipped catheter 1.0 sham ACF 2 days 98891 2160
SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc urine sodium level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine sodium amount male 126 days 9 268.97 mmol/l 32.7 98.1 urine sodium analysis 0.0 0 102138 2646
SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc urine urea level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 7 316.61 mmol/l 113.57 300.48 urine urea analysis 0.0 0 102149 2646
WKY/Gcrc urine creatinine level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine creatinine amount male 126 days 18 13.91 mg/dl 5.29 22.45 urine creatinine analysis 0.0 0 102152 2646
WKY/NHsd skin potassium level plus skin sodium level to skin water level ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin mineral amount male 0 days 7 0.18 null 0.01 0.02 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin na+k/h2o 99145 2238
HanTac:WH anogenital distance vehicle control condition (for 1 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. perineum length female 1 days 17 2.2 mm 0.02 0.1 in vivo stereo light microscopy 0.0 0 96622 1559
HanTac:WH ventral prostate gland wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. ventral prostate mass male 16 days-17 days 18 0.01 g 0.0 0.0 post excision weight measurement 0.0 0 96647 1559
BluHsd:LE total food calorie intake rate vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. eating behavior trait male 71 days-98 days 8 2103.7 kcal/d 62.9 177.91 unspecified method 0.0 0 76169 1543
Hsd:WI kidney glutathione level vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney glutathione amount male 0 days 6 7882.76 ug/g 178.16 436.39 liquid phase colorimetry 0.0 0 76239 1544
Crl:CD(SD) serum estradiol level maternal milk (for 20 days) and vehicle control condition (for 15 days) Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. blood estradiol amount female 50 days 32 34.4 pg/ml 2.7 15.27 radioimmunoassay 0.0 0 76260 1558
Hsd:WI liver wet weight vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. liver mass male 119 days-126 days 5 13.6 g 1.05 2.34 post excision weight measurement 0.0 0 76090 1545
BluHsd:LE food calorie intake level to change in body weight ratio controlled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. eating behavior trait male 71 days-98 days 8 10.4 kcal/g 0.3 0.85 unspecified method 0.0 0 76198 1543
HanTac:WH both epididymides wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. epididymis mass male 16 days-17 days 18 0.02 g 0.0 0.0 post excision weight measurement 0.0 0 96652 1559
HanTac:WH liver wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. liver mass male 16 days-17 days 18 0.75 g 0.03 0.11 post excision weight measurement 0.0 0 96672 1559
SHRSP.WKY-(D3Wox20-D3Rat114)/Gcrc heart weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart mass male 126 days 6 4.47 g/kg 0.27 0.66 post excision weight measurement 0.0 0 102103 2646
SHRSP.WKY-(D3Mgh16-D3Wox3)/Gcrc heart weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart mass male 126 days 7 4.07 g/kg 0.17 0.45 post excision weight measurement 0.0 0 102105 2646
SHRSP.WKY-(D3Mgh16-D3Rat80)/Gcrc heart left ventricle weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart left ventricle mass male 126 days 0 2.79 mg/g 0.14 post excision weight measurement 0.0 0 102113 2646
SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc heart left ventricle weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart left ventricle mass male 126 days 0 3.12 mg/g 0.24 post excision weight measurement 0.0 0 102115 2646
SS/NEisSlc heart left ventricle end-diastolic diameter controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. heart left ventricle end-diastolic diameter male 126 days 8 8.7 mm 0.3 0.85 transthoracic echocardiography 0.0 0 102320 2684
SS/NEisSlc serum urea nitrogen level controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. blood urea nitrogen amount male 126 days 8 33.6 mg/dl 4.1 11.6 serum urea nitrogen analysis 0.0 0 102329 2684
GK/Slc blood total cholesterol level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood cholesterol amount male 105 days 0 77.8 mg/dl 5.2 blood cholesterol analysis 0.0 0 n=4-6 102892 2781
GK/Slc blood low density lipoprotein cholesterol level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood LDL cholesterol amount male 105 days 0 24.3 mg/dl 1.8 blood low-density lipoprotein-cholesterol measurement test 0.0 0 n=4-6 102900 2781
Slc:W blood urea nitrogen level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood urea nitrogen amount male 105 days 0 19.8 mg/dl 0.6 blood urea nitrogen analysis 0.0 0 n=4-6 102902 2781
Slc:W blood creatinine level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood creatinine amount male 105 days 0 0.33 mg/dl 0.01 blood creatinine analysis 0.0 0 n=4-6 102906 2781
GK/Slc urine 3-hydroxybutyrate level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. urine ketone body amount male 105 days 0 323.3 umol/l 92.7 urine analysis 0.0 0 n=4-6 102920 2781
LH/Mav body weight vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. body mass male 56 days 11 246.0 g 4.0 13.27 body weighing method 0.0 0 102700 2721
PCK-Pkhd1pck/CrljCrl blood urea nitrogen level control condition (for 28 days) then vehicle control condition (for 84 days) Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. blood urea nitrogen amount male 112 days 5 20.6 mg/dl 1.8 4.02 blood urea nitrogen analysis 0.0 0 100763 2521
LH/Mav blood glucose level vehicle control condition then fasting (for 16 hours) then glucose (2 g/kg) (for 1 hours) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood glucose amount male 56 days 11 127.0 mg/dl 3.0 9.95 blood glucose analysis 0.0 0 102720 2721
LL/Mav systolic blood pressure vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. arterial blood pressure trait male 112 days 9 mean of 3 samples of undefined duration serial mean 119.0 mmHg 4.0 12.0 tail cuff plethysmography 0.0 0 102726 2721
LH/Mav urine albumin excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 11 24.0 mg/d 4.6 15.26 urine albumin analysis 0.0 0 102740 2721
LL/Mav urine albumin level to urine total protein level ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 9 11.9 % 0.7 2.1 urine albumin analysis 0.0 0 102742 2721
LL/Mav plasma total cholesterol level vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood cholesterol amount male 112 days 9 62.55 mg/dl 4.25 12.74 plasma total cholesterol measurement test 0.0 0 102750 2721
LH/Mav plasma triglyceride level vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood triglyceride amount male 112 days 11 1.43 mmol/l 0.16 0.53 plasma triglyceride analysis 0.0 0 102756 2721
SS-Nppbem2Mcwi-/- heart interventricular end-diastolic septal wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart ventricle septum thickness male 252 days 7 2.26 mm 0.23 0.61 echocardiography 0.0 0 99766 2319
Crlj:WI mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 6 undefined 138.0 mmHg 9.0 22.05 vascular transducer tipped catheter 0.0 0 103015 2784
GK mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 5 undefined 137.0 mmHg 6.0 13.42 vascular transducer tipped catheter 0.0 0 103017 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 109.0 mmHg 10.0 26.46 vascular transducer tipped catheter 0.0 0 103024 2784
GK heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 5 395.0 beats/min 17.0 38.01 vascular transducer tipped catheter 0.0 0 103037 2784
Crlj:WI heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 6 90.0 beats/min 15.0 36.74 vascular transducer tipped catheter 0.0 0 103039 2784
Crlj:WI heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 6 275.0 beats/min 8.0 19.6 vascular transducer tipped catheter 0.0 0 103051 2784
Crlj:WI heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 264.0 beats/min 9.0 23.81 vascular transducer tipped catheter 0.0 0 103052 2784
GK diastolic blood pressure vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 104.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks nighttime measurement 103552 2827
GK heart rate vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 168 days 6 323.0 beats/min 8.0 19.6 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks nighttime measurement 103568 2827
WF/Mol systolic blood pressure vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. arterial blood pressure trait male 0 days 5 undefined 123.0 mmHg 5.0 11.18 tail cuff plethysmography 0.0 sham acf 4 days 101347 2585
WF/Mol systolic blood pressure vehicle control condition then artificial aortocaval fistula (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. arterial blood pressure trait male 0 days 5 undefined 125.0 mmHg 10.0 22.36 tail cuff plethysmography 0.0 acf 2 days 101356 2585
WF/Mol heart rate vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 6 460.0 beats/min 9.0 22.05 tail cuff plethysmography 0.0 acf 4 days 101368 2585
WF/Mol heart left ventricle weight vehicle control condition then artificial aortocaval fistula (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart left ventricle mass male 0 days 8 0.24 g 0.01 0.01 post excision weight measurement 0.0 acf 2 days 101400 2585
WF/Mol heart left ventricle weight vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart left ventricle mass male 0 days 5 0.21 g 0.0 0.01 post excision weight measurement 0.0 sham acf 4 days 101405 2585
WKY/NCrl number of spontaneous locomotor movements per unit time vehicle control condition (between 1 and 28 days) and dark phase of controlled light/dark cycle Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. voluntary movement trait male 168 days 6 2.8 /min 0.3 0.73 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks number of spontaneous locomotor movements per unit time (CMO:0003644) 103582 2827
GK number of spontaneous locomotor movements per unit time vehicle control condition (between 1 and 28 days) and dark phase of controlled light/dark cycle Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. voluntary movement trait male 168 days 6 2.9 /min 0.1 0.24 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks number of spontaneous locomotor movements per unit time (CMO:0003644) 103584 2827
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -7.07 null 0.05 0.14 wire myography 0 103586 2827
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -7.6 null 0.05 0.13 wire myography 0.0 0 103602 2827
GK aorta wall phosphorylated eNOS level to total eNOS level ratio vehicle control condition (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. artery molecular composition trait male 175 days 8 1.61 null 0.3 0.85 western blot assay 0.0 0 103620 2827
WI neuron golgi apparatus area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 1.05 % 0.04 0.08 ex vivo electron microscopy with digital image analysis 0.0 0 ga/cyto 103650 2844
OXYS/Nov neuron golgi apparatus area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 1.2 % 0.04 0.08 ex vivo electron microscopy with digital image analysis 0.0 0 ga/cyto 103651 2844
MW urine total protein excretion rate unilateral nephrectomy (for 70 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. total urine protein amount male 0 days 7 18.0 mg/d 4.0 10.58 Bradford protein assay 0.0 unx 70 days 101200 2581
SS-Nppbem2Mcwi-/- heart interventricular end-diastolic septal wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart ventricle septum thickness male 84 days 7 2.01 mm 0.08 0.21 echocardiography 0.0 0 99762 2319
WKY/NCrl water intake drink rate to body weight ratio vehicle control condition (between 1 and 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. drinking behavior trait male 140 days-175 days 6 50.0 ml/d/kg 1.0 2.45 drink intake measuring method 0 103498 2827
WKY/NCrl blood glucose level vehicle control condition (for 28 days) then fasting (for 16 hours) then glucose (2 g/kg) (for 2 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood glucose amount male 168 days 6 125.0 mg/dl 3.0 7.35 oral glucose tolerance test 0.0 0 103518 2827
WF/Mol systolic blood pressure vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. arterial blood pressure trait male 0 days 6 undefined 103.0 mmHg 6.0 14.7 tail cuff plethysmography 0.0 acf 4 days 101346 2585
LH/Mav urine creatinine excretion rate vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. urine creatinine amount male 49 days-56 days 8 8.0 mg/d 0.3 0.85 urine creatinine analysis 0.0 0 102651 2703
SS-Nppbem2Mcwi-/- heart left ventricle end-diastolic diameter vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-diastolic diameter male 252 days 7 7.99 mm 0.62 1.64 echocardiography 0.0 0 99772 2319
WF/Mol heart right ventricle weight vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 5 0.06 g 0.0 0.0 post excision weight measurement 0.0 sham acf 7 days 101417 2585
WKY blood glucose level vehicle control condition (1 null) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. blood glucose amount male 156 days 10 160.56 mg/dl 8.64 27.32 radioimmunoassay 0.0 0 99101 2219
LH/Mav plasma triglyceride level vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood triglyceride amount male 112 days 8 1.57 mmol/l 0.06 0.17 plasma triglyceride analysis 0.0 0 102669 2703
LH/MavRrrc plasma creatinine level vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood creatinine amount male 112 days 8 0.53 mg/dl 0.01 0.03 plasma creatinine analysis 0.0 0 102675 2703
SS.ZUC-Leprfa-/-/Slc tibia straight segment length vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. tibia length male 91 days 13 34.62 mm 0.15 0.54 body measuring method 0.0 0 101971 2644
SS.ZUC-Leprfa-/-/Slc heart weight to tibia length ratio vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart mass male 91 days 13 0.43 g/cm 0.01 0.04 post excision weight measurement 0.0 0 101974 2644
SS-Nppbem2Mcwi-/- systolic blood pressure vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. arterial blood pressure trait male 252 days 7 serial mean 197.0 mmHg 26.0 68.79 tail cuff plethysmography 0.0 0 99832 2319
SS-Nppbem2Mcwi-/- timed urine volume vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. urine output male 252 days 7 19.5 ml/d 4.6 12.17 urine volume measurement method 0.0 0 99844 2319
WF/Mol body weight gain vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 7 -5.0 g 2.0 5.29 body weighing method 0.0 acf 4 days change from surgery weight 101338 2585
SS-Nppbem2Mcwi-/- heart left ventricle end-systolic posterior wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle posterior wall thickness male 168 days 7 3.17 mm 0.17 0.45 echocardiography 0.0 0 99794 2319
SS.ZUC-Leprfa-/-/Slc body weight bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. body mass female 91 days 8 393.0 g 6.0 16.97 body weighing method 0.0 ovariectomy 42 days 101663 2622
SS.ZUC-Leprfa+/+/Slc heart left ventricle posterior wall thickness bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle posterior wall thickness female 91 days 9 1.5 mm 0.02 0.06 echocardiography 0.0 ovariectomy 42 days 101711 2622
SS.ZUC-Leprfa+/+/Slc calculated heart left ventricle weight bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle mass female 91 days 9 764.0 mg 27.0 81.0 echocardiography 0.0 ovariectomy 42 days 101723 2622
SS.ZUC-Leprfa-/-/Slc heart left ventricle relative wall thickness bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle wall thickness female 91 days 8 57.0 % 2.0 5.66 echocardiography 0.0 ovariectomy 42 days 101729 2622
SS.ZUC-Leprfa-/-/Slc myocardial performance index bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 8 0.61 null 0.03 0.08 echocardiography 0.0 ovariectomy 42 days 101741 2622
SS.ZUC-Leprfa+/+/Slc time constant of left ventricular pressure decay bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricular blood pressure trait female 91 days 9 36.2 ms 0.5 1.5 echocardiography 0.0 ovariectomy 42 days 101747 2622
SS.ZUC-Leprfa-/-/Slc heart left ventricular end-diastolic blood pressure to heart left ventricular end-diastolic diameter ratio bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricular blood pressure trait female 91 days 8 0.63 mmHg/mm 0.05 0.14 echocardiography 0.0 ovariectomy 42 days 101753 2622
MWF/ZtmRrrc body weight vehicle control condition Remuzzi A, et al., J Clin Invest. 1990 Feb;85(2):541-9. body mass male 126 days 7 385.0 g 11.34 30.0 body weighing method 0.0 0 100903 2541
MWF/ZtmRrrc body weight vehicle control condition Remuzzi A, et al., J Clin Invest. 1990 Feb;85(2):541-9. body mass male 246 days 8 433.0 g 9.19 26.0 body weighing method 0.0 0 100905 2541
WF/Mol body weight vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 8 194.0 g 3.0 8.49 body weighing method 0.0 acf 4 days 101316 2585
WF/Mol body weight gain vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 7 -10.0 g 3.0 7.94 body weighing method 0.0 acf 4 days change from surgery weight 101324 2585
WF/Mol body weight gain vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 5 12.0 g 3.0 6.71 body weighing method 0.0 acf 7 days change from surgery weight 101328 2585
WKY/NHsd plasma potassium level standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood potassium amount male 0 days 7 3.9 mmol/l 0.2 0.53 automated blood electrolyte analysis 0.0 0 99163 2238
SS-Nppbem2Mcwi-/- heart left ventricle weight vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle mass male 84 days 7 1.53 g 0.08 0.21 echocardiography 0.0 0 99810 2319
SS-Nppbem2Mcwi-/- heart rate vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart pumping trait male 84 days 7 382.0 beats/min 45.0 119.06 echocardiography 0.0 0 99816 2319
SD-Nfe2l2em1Mcwi-/- middle cerebral artery inner diameter controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. cerebral artery size trait male 9 days-11 days 4 248.0 um 9.0 18.0 ex vivo method 0.0 0 max dilation 100746 2520
WKY/NHsd creatinine clearance controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. glomerular filtration trait male 0 days 7 3.5 ml/min 0.3 0.79 urine creatinine analysis 0.0 0 99181 2238
SS.ZUC-Leprfa-/-/Slc heart left ventricle relative wall thickness vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricle wall thickness male 91 days 13 49.0 % 1.0 3.61 echocardiography 0.0 0 102004 2644
SS.ZUC-Leprfa-/-/Slc heart isovolumetric relaxation time vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart muscle relaxation trait male 91 days 13 40.75 ms 2.42 8.73 echocardiography 0.0 0 102016 2644
SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc timed urine volume vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine output male 126 days 7 30.68 ml/d 11.32 29.95 metabolic cage urine volume measurement method 0.0 0 102134 2646
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc urine sodium level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine sodium amount male 126 days 6 169.89 mmol/l 27.46 67.26 urine sodium analysis 0.0 0 102140 2646
WKY/Gcrc urine urea level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 18 235.52 mmol/l 90.62 384.47 urine urea analysis 0.0 0 102147 2646
WKY/NHsd skin sodium level to skin dry weight ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin sodium amount male 0 days 7 0.14 REQUEST NEW VALUE 0.01 0.01 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin mmol/g 99133 2238
WKY/NHsd urine sodium excretion rate standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. urine sodium amount male 0 days 7 1.0 mEq/d 0.2 0.53 urine sodium analysis 0.0 0 mmol/d 99183 2238
WKY ejection fraction left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. cardiac output trait male 238 days-252 days 30 37.0 % 1.4 7.67 echocardiography 0.0 lad occlusion 196 days 100353 2460
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 8 350.0 mg/dl 18.0 50.91 machine read blood glucose test strip 0.0 unx 28 days 99941 2378
WKY renal vascular resistance unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. arterial blood pressure trait male 0 days 7 10.0 mmHg/ml/min 0.6 1.59 p-aminohippurate analysis by liquid phase colorimetry 0.0 unx 28 days 99960 2378
SS-Sod3m1Mcwi heart right ventricle weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56 days 10 0.16 g 0.0 0.01 post excision weight measurement 0.0 0 106541 3032
SS/JrHsdMcwi tibia length vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. tibia length male 56 days 7 3.64 cm 0.06 0.16 post excision length measurement 0.0 0 106554 3032
SS/JrHsdMcwi left atrium weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left atrium mass male 56 days 7 0.01 g 0.0 0.0 post excision weight measurement 0.0 0 106566 3032
SS-Sod3m1Mcwi heart right atrium weight to left atrium weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56 days 10 0.94 null 0.09 0.28 post excision weight measurement 0.0 0 106571 3032
SS/JrHsdMcwi heart left ventricle weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left ventricle mass male 56 days 7 0.18 g/cm 0.01 0.02 post excision weight measurement 0.0 0 106614 3032
SS-Sod3m1Mcwi heart left ventricle weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left ventricle mass male 56 days 10 0.18 g/cm 0.0 0.01 post excision weight measurement 0.0 0 106615 3032
SD retinal uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina blood vessel morphology trait male 35 days-49 days 3 24.0 % 5.8 10.05 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106117 3028
SD brain uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. blood-brain barrier morphology trait male 35 days-49 days 3 2.12 % 0.12 0.21 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106150 3028
SD-Ahrem2Sage blood monocyte count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. monocyte quantity female 84 days 10 0.31 x 1000 cells/ul 0.09 0.28 automated hematology analysis 0 106053 3021
SD-Ahrem2Sage blood basophil count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. basophil quantity female 84 days 10 0.08 x 1000 cells/ul 0.02 0.06 automated hematology analysis 0 106077 3021
SS/JrHsdMcwi heart left atrium weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left atrium mass male 56 days 7 0.41 mg/mm 0.02 0.05 post excision weight measurement 0.0 0 106626 3032
SS/JrHsdMcwi liver weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56 days 7 29.2 mg/mm 1.28 3.39 post excision weight measurement 0.0 0 106630 3032
Crl:CD(SD) retinal outer layer thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111 days-118 days 5 132.2 um 3.71 8.3 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography outer retinal layer 105490 3016
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136 days-143 days 5 123.8 um 4.83 10.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography inner retinal layer 105502 3016
Crl:CD(SD) retinal outer layer thickness vehicle control condition (0 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67 days-74 days 5 138.5 um 3.4 7.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography outer retinal layer 105474 3016
SS/JrHsdMcwi diastolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56 days 6 84.0 mmHg 4.05 9.92 vascular fluid filled catheter 0.0 0 106806 3032
SS/NEisSlc heart weight to body weight ratio vehicle control condition (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. heart mass not specified 547 days 10 3.2 g/kg 0.1 0.32 post excision weight measurement 0.0 0 106792 2339
SD-Abcb1aem1Sage-/- brain uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. blood-brain barrier morphology trait male 42 days-56 days 3 26.1 % 2.4 4.16 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106159 3028
SD serum total immunoglobulin E level vehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days) Zhuang ZM, et al., Int J Clin Exp Med. 2015 May 15;8(5):6866-77. eCollection 2015. blood immunoglobulin E amount not specified 0 days 4 0.2 ug/l 0.0 0.0 enzyme linked immunosorbent assay 0.0 0 error not defined 105407 3015
Hsd:SD thymus weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. thymus mass female 84 days 10 1.5 mg/g 0.35 1.11 post excision weight measurement 0 105884 3021
SD-Ahrem2Sage both ovaries weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. ovary mass female 84 days 10 0.05 % 0.01 0.02 post excision weight measurement 0 105921 3021
SD-Ahrem2Sage blood hemoglobin level vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 14.01 g/dl 0.62 1.96 automated hematology analysis 0 105945 3021
MWF/FubRkb body weight vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. body mass male 112 days 10 362.8 g 12.8 40.48 body weighing method 0.0 0 109389 3140
Hsd:SD scotopic A wave amplitude of ERG waveform vehicle control condition (2 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. rod electrophysiology trait both 0 days 4 142.0 uV electroretinography cornea 0.0 subretinal injection 30 days scotopic a-wave ERG 108642 3128
RCS-p+/LavRrrc optokinetic reflex vehicle control condition (2 ul) then visible light stimulus (25 cd x s/m2) Baranov P, et al., J Ocul Pharmacol Ther. 2017 Jun;33(5):412-422. doi: 10.1089/jop.2016.0121. Epub 2017 Apr 25. eye physiology trait not specified 119 days 7 6.0 s 0.27 0.71 optokinetic reflex test method 60.0 intravitrial injection 98 days 109741 3154
SHRSP/A3NCrl blood urea nitrogen level controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. blood urea nitrogen amount male 161 days-175 days 6 20.5 mg/dl 5.8 14.21 blood urea nitrogen analysis 0.0 0 107391 3083
WAG/Nov CD4-CD8+ thymocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymocyte quantity male 150 days-180 days 10 74.18 x10E6/organ 11.97 37.85 flow cytometry method 0.0 IP injeciton 1 days saline cd4-cd8+ t-cell 107724 3096
ISIAH CD11b/c+ splenocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 50.17 x10E6/organ 10.65 33.68 flow cytometry method 0.0 IP injeciton 1 days saline cd11b/c+ spleen 107760 3096
ISIAH CD3+ thymocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymocyte quantity male 150 days-180 days 10 716.82 x10E6/organ 91.79 290.27 flow cytometry method 0.0 IP injeciton 1 days saline cd3+ thymus 107763 3096
ISIAH CD4-CD8+ thymocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymocyte quantity male 150 days-180 days 10 63.99 x10E6/organ 6.25 19.76 flow cytometry method 0.0 IP injeciton 1 days saline cd4-cd8+ t-cell 107769 3096
ISIAH CD4+CD25+ thymocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymocyte quantity male 150 days-180 days 10 32.19 x10E6/organ 7.15 22.61 flow cytometry method 0.0 IP injeciton 1 days saline cd4+cd25+ t-cell 107772 3096
ISIAH plasma total cholesterol level vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. blood cholesterol amount male 150 days-180 days 10 59.5 mg/dl 3.2 10.12 plasma total cholesterol measurement test 0.0 IP injeciton 1 days saline 107784 3096
WAG/Nov plasma high density lipoprotein phospholipid level vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. blood HDL phospholipid amount male 150 days-180 days 10 47.1 mg/dl 4.1 12.97 plasma high-density lipoprotein-cholesterol measurement test 0.0 IP injeciton 1 days saline 107787 3096
ISIAH plasma high density lipoprotein phospholipid level vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. blood HDL phospholipid amount male 150 days-180 days 10 36.2 mg/dl 2.4 7.59 plasma high-density lipoprotein-cholesterol measurement test 0.0 IP injeciton 1 days saline 107790 3096
BDIX/CrCrl blood hemoglobin level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood hemoglobin amount male 71 days 10 19.9 g/dl 0.66 2.1 blood hemoglobin analysis 0.0 0 hemoglobin, MCH, MCHC 107831 3097
Crl:WI timed urine volume vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. urine output male 114 days 10 11.1 ml/d 1.3 4.11 metabolic cage urine volume measurement method 0.0 0 109399 3140
Crl:WI mesenteric artery wall thickness vehicle control condition Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. mesenteric artery morphology trait male 114 days 10 37.8 um 1.5 4.74 confocal microscopy 0.0 0 109419 3140
MWF/FubRkb norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasoconstriction trait male 114 days 10 77.8 % 10.2 32.26 wire myography 0.0 0 109441 3140
SHRSP/A3N ratio of deaths related to chronic hypertension to total study population during a period of time controlled sodium chloride content drinking water (1 %) (for 63 days) and controlled fat content diet (24.5 %) (for 63 days) and vehicle control condition (for 63 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. total life span male 147 days-168 days 25 95.0 % unspecified method 0.0 0 ratio of deaths related to chronic hypertension to total study population during a period of time (CMO:0003800) 107518 3090
SHRSP/A3N kidney weight controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney mass male 126 days-182 days 0 2.65 g 0.1 post excision weight measurement kidney 0.0 0 107531 3090
SHRSP/A3N renal fibrosis foci count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 16.4 /section 1.4 ex vivo light microscopy with histochemistry 0.0 0 107559 3090
BDIX/CrCrl red blood cell distribution width-coefficient of variation DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. erythrocyte size trait male 92 days 10 17.7 % 0.13 0.4 automated hematology analysis 0.0 0 MCV, RDW% 107848 3097
BDIX/CrCrl serum alanine aminotransferase activity level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood alanine transaminase amount male 71 days 10 59.2 U/l 1.99 6.3 automated serum analysis 0.0 0 serum alanine aminotransferase 107907 3097
WKY heart weight to body weight ratio unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. heart mass male 0 days 17 3.5 g/kg 0.1 0.41 post excision weight measurement 0.0 unx 150 days 107451 2378
BDIX/CrCrl serum urea nitrogen level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood urea nitrogen amount male 71 days 10 35.0 mg/dl 0.57 1.8 automated serum analysis 0.0 0 serum BUN 107887 3097
BDIX/CrCrl red blood cell count DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. erythrocyte quantity male 71 days 10 11.0 x 10E6 cells/ul 0.41 1.3 automated blood cell counting method 0.0 0 red blood cell count, hematocrit 107801 3097
RCS/LavRrrc scotopic B wave amplitude of ERG waveform vehicle control condition (2 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus Huang L, et al., Stem Cell Res Ther. 2017 Dec 22;8(1):290. doi: 10.1186/s13287-017-0731-y. rod electrophysiology trait not specified 35 days 4 95.22 uV 16.19 32.38 electroretinography retina 0.0 pbs vehicle injection 14 days 109856 3157
BDIX/CrCrl blood lymphocyte count DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. lymphocyte quantity male 71 days 10 62.8 x 1000 cells/ul 0.32 1.0 automated differential white blood cell count test 0.0 0 LYM 107861 3097
SHRSP/A3N interstitial nephritis foci count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 8.5 /section 1.2 ex vivo light microscopy with histochemistry 0.0 0 107551 3090
MWF/FubRkb tibia length vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. tibia length male 113 days 10 4.2 cm 1.0 3.16 post excision length measurement 0.0 0 109397 3140
WKY left kidney wet weight to body weight ratio unilateral nephrectomy (for 150 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney mass male 0 days 11 3.9 mg/g 0.1 0.33 post excision weight measurement 0.0 unx 150 days 107455 2378
BluHsd:LE body weight vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. body mass male 98 days 8 491.1 g 20.4 57.7 body weighing method 0.0 0 76148 1543
BluHsd:LE body weight vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. body mass male 70 days 8 353.1 g 10.8 30.55 body weighing method 0.0 0 75955 1543
HanTac:WH left testis wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. testis mass male 16 days-17 days 18 50.9 mg 1.74 7.4 post excision weight measurement 0.0 0 96642 1559
Hsd:SD serum alanine aminotransferase activity level fasting (between 12 and 15 hours) then vehicle control condition (for 1 days) McGill MR, et al., Toxicol Appl Pharmacol. 2012 Nov 1;264(3):387-94. doi: 10.1016/j.taap.2012.08.015. Epub 2012 Aug 23. blood alanine transaminase amount not specified 56 days-84 days 4 30.0 U/l 1.0 2.0 spectrophotometry 0.0 0 84757 1601
Hsd:WI both kidneys wet weight vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney mass male 0 days 6 1.2 g 0.05 0.13 post excision weight measurement 0.0 0 75957 1544
LH/Mav systolic blood pressure vehicle control condition Issiakhem M, et al., J Cardiovasc Pharmacol. 2008 Mar;51(3):280-5. doi: 10.1097/FJC.0b013e31816299a5. arterial blood pressure trait male 84 days 8 undefined 160.0 mmHg tail cuff plethysmography 0.0 0 102849 2761
Hsd:SD liver weight as percentage of body weight vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. liver mass female 84 days 10 3.65 % 0.2 0.63 post excision weight measurement 0.0 0 105720 3021
F344 cerebrum infarct volume to total cerebrum volume ratio isoflurane (1.5 %) (for 4 hours) then vehicle control condition then middle cerebral artery occlusion (for 1 hours) Yang F, et al., J Pharm Pharm Sci. 2014;17(3):362-70. cerebrum integrity trait male 0 days 6 18.0 % 6.0 14.7 ex vivo light microscopy with histochemistry and digital image analysis 0.0 cerebral ischemia 1 days 106361 3029
SS-Sod3m1Mcwi heart right atrium weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56 days 10 0.06 mg/g 0.01 0.03 post excision weight measurement 0.0 0 106595 3032
Hsd:SD blood lymphocyte count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. lymphocyte quantity female 84 days 10 7.36 x 1000 cells/ul 1.77 5.6 automated hematology analysis 0 106040 3021
Hsd:SD blood eosinophil count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. eosinophil quantity female 84 days 10 0.13 x 1000 cells/ul 0.14 0.44 automated hematology analysis 0 106064 3021
GK heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 390.0 beats/min 10.0 26.46 vascular transducer tipped catheter 0.0 0 103046 2784
LH/Mav blood glucose level vehicle control condition then fasting (for 16 hours) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood glucose amount male 49 days-56 days 8 67.0 mg/dl 1.0 2.83 blood glucose analysis 0.0 0 102657 2703
WKY timed urine volume unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 17 39.46 ml/d 4.61 19.0 metabolic cage urine volume measurement method 0.0 unx 168 days 100001 2378
MW blood urea nitrogen level unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. blood urea nitrogen amount male 0 days 7 25.0 mg/dl 3.0 7.94 blood urea nitrogen analysis 0.0 unx 42 days 101182 2581
MW glomerular filtration rate unilateral nephrectomy (for 70 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. glomerular filtration trait male 0 days 7 1.46 ml/min 0.08 0.21 inulin analysis by liquid phase colorimetry 0.0 unx 70 days 101205 2581
Hsd:WI serum creatinine level vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. blood creatinine amount male 0 days 6 1.69 mg/dl 0.06 0.14 serum creatinine analysis 0.0 0 75973 1544
LL/Mav urine creatinine excretion rate vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. urine creatinine amount male 49 days-56 days 13 7.1 mg/d 0.3 1.08 urine creatinine analysis 0.0 0 102650 2703
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure vehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 32.0 mmHg 2.0 4.9 vascular indwelling catheter method 0.0 0 84568 1120
BluHsd:LE both testes wet weight vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. testis mass male 98 days 8 3.4 g 0.3 0.85 post excision weight measurement 0.0 0 76233 1543
WKY/NHsd plasma potassium level controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood potassium amount male 0 days 7 4.2 mmol/l 0.3 0.79 automated blood electrolyte analysis 0.0 0 99165 2238
SS-Nppbem2Mcwi-/- heart rate vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart pumping trait male 252 days 7 327.0 beats/min 19.0 50.27 echocardiography 0.0 0 99820 2319
SHRSP.WKY-(D3Mgh16-rs197649383)/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 4.25 g/kg 0.7 post excision weight measurement 0.0 0 102124 2646
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc water drink intake rate vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. drinking behavior trait male 126 days 6 79.16 ml/d 16.78 41.1 metabolic cage water drinking measurement method 0.0 0 102130 2646
WF/Mol body weight vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 5 180.0 g 2.0 4.47 body weighing method 0.0 7 days 101307 2585
WF/Mol body weight vehicle control condition then artificial aortocaval fistula (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 8 202.0 g 3.0 8.49 body weighing method 0.0 acf 2 days 101312 2585
WF/Mol body weight vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 6 201.0 g 3.0 7.35 body weighing method 0.0 7 days 101321 2585
WF/Mol body weight gain vehicle control condition then sham surgical control condition (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 6 -6.0 g 1.0 2.45 body weighing method 0.0 sham acf 2 days change from surgery weight 101335 2585
SS.ZUC-Leprfa+/+/Slc heart left ventricular end-diastolic blood pressure to heart left ventricular end-diastolic diameter ratio bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricular blood pressure trait female 91 days 9 0.32 mmHg/mm 0.02 0.06 echocardiography 0.0 ovariectomy 42 days 101751 2622
WKY glomerular filtration rate to body weight ratio unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 8 0.79 ml/min/100g 0.03 0.08 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99946 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 7 12.38 ml/d 2.02 5.33 metabolic cage urine volume measurement method 0.0 unx 28 days 99965 2378
WKY heart ventricle septal wall thickness left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle wall thickness male 238 days-252 days 30 0.1 cm 0.0 0.02 echocardiography 0.0 lad occlusion 196 days 100338 2460
HanTac:WH anogenital distance vehicle control condition (for 1 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. perineum length male 1 days 17 4.1 mm 0.02 0.07 in vivo stereo light microscopy 0.0 0 96617 1559
SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc urine potassium level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine potassium amount male 126 days 7 80.72 mmol/l 27.0 71.44 urine potassium analysis 0.0 0 102144 2646
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc urine creatinine level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine creatinine amount male 126 days 6 5.37 mg/dl 1.52 3.73 urine creatinine analysis 0.0 0 102155 2646