Phenominer Database Results (969 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
HanTac:WH litter size vehicle control condition (for 14 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. single birth offspring quantity female 0 days 18 11.8 null 0.78 3.3 in vivo visual assessment 0.0 0 96597 1559
HanTac:WH body weight vehicle control condition (for 1 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. body mass male 1 days 17 6.2 g 0.12 0.5 body weighing method 0.0 0 96612 1559
HanTac:WH body weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. body mass female 16 days-17 days 15 29.1 g 0.67 2.6 body weighing method 0.0 0 96687 1559
BluHsd:LE serum testosterone level vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. blood testosterone amount male 98 days 8 10.0 ng/ml 1.2 3.39 radioimmunoassay 0.0 0 tritium-based 76253 1543
Hsd:WI kidney lipid peroxide level vehicle control condition (for 10 days) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney lipid peroxide amount male 0 days 6 0.75 nmol/mg 0.02 0.04 liquid phase colorimetry 0.0 0 76256 1544
Hsd:WI serum albumin level vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. blood albumin amount male 119 days-126 days 5 0.04 g/dl 0.0 0.0 liquid phase colorimetry 0.0 0 76149 1545
Hsd:WI serum urea nitrogen level vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. blood urea nitrogen amount male 119 days-126 days 5 77.76 mg/dl 3.18 7.11 liquid phase colorimetry 0.0 0 76164 1545
HanTac:WH body weight gain vehicle control condition (for 14 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. body mass female 0 days 18 82.4 g 6.22 26.4 body weighing method 0.0 0 G7-G21 76270 1559
WKY/Izm absolute change in mean arterial blood pressure vehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 27.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 84566 1120
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm absolute change in mean arterial blood pressure vehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) then phenylephrine (3 ug) Yamazato M, et al., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20. arterial blood pressure trait male 98 days 6 50.0 mmHg 3.0 7.35 vascular indwelling catheter method 0.0 0 84572 1120
F344/NHsd serum alanine aminotransferase activity level fasting (between 12 and 15 hours) then vehicle control condition (for 1 days) McGill MR, et al., Toxicol Appl Pharmacol. 2012 Nov 1;264(3):387-94. doi: 10.1016/j.taap.2012.08.015. Epub 2012 Aug 23. blood alanine transaminase amount not specified 56 days-84 days 4 35.0 U/l 11.0 22.0 spectrophotometry 0.0 0 84754 1601
BluHsd:LE body weight gain vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. body mass male 71 days-98 days 8 104.6 g 5.9 16.69 body weighing method 0.0 0 75969 1543
Hsd:WI serum urea nitrogen level vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. blood urea nitrogen amount male 0 days 6 96.11 mg/dl 1.91 4.69 liquid phase colorimetry 0.0 0 75977 1544
HanTac:WH combined levator ani and bulbocavernosus muscle weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. skeletal muscle mass male 16 days-17 days 18 26.0 mg 1.04 4.4 post excision weight measurement 0.0 0 96662 1559
HanTac:WH liver wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. liver mass male 16 days-17 days 18 0.75 g 0.03 0.11 post excision weight measurement 0.0 0 96672 1559
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc heart weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart mass male 126 days 0 4.67 g/kg 0.4 post excision weight measurement 0.0 0 102108 2646
SHRSP/Gcrc heart left ventricle weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart left ventricle mass male 126 days 0 3.64 mg/g 0.39 post excision weight measurement 0.0 0 102109 2646
WKY/Gcrc heart left ventricle weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart left ventricle mass male 126 days 0 2.52 mg/g 0.2 post excision weight measurement 0.0 0 102110 2646
SHRSP/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 4.11 g/kg 0.25 post excision weight measurement 0.0 0 102118 2646
SHRSP.WKY-(D3Mgh16-D3Rat80)/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 3.77 g/kg 0.12 post excision weight measurement 0.0 0 102122 2646
SS/NEisSlc serum urea nitrogen level controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. blood urea nitrogen amount male 126 days 8 33.6 mg/dl 4.1 11.6 serum urea nitrogen analysis 0.0 0 102329 2684
SS/NEisSlc creatinine clearance controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. glomerular filtration trait male 126 days 8 1.9 ml/min 0.5 1.41 serum creatinine analysis 0.0 0 102332 2684
SS/NEisSlc urine total protein excretion rate controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. total urine protein amount male 126 days 8 307.0 mg/d 46.0 130.11 urine protein analysis 0.0 0 102338 2684
PCK-Pkhd1pck/CrljCrl urine protein level to urine creatinine level ratio control condition (for 28 days) then vehicle control condition (for 84 days) Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. total urine protein amount male 112 days 6 12.0 null 1.7 4.16 urine protein analysis 0.0 0 100769 2521
SD serum parathyroid hormone level controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. blood parathyroid hormone amount female 0 days 13 3496.0 pg/ml 862.0 3107.99 serum parathyroid hormone analysis 0.0 unx 97 days 100647 2499
GK/Slc blood creatinine level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood creatinine amount male 105 days 0 0.26 mg/dl 0.02 blood creatinine analysis 0.0 0 n=4-6 102908 2781
GK/Slc urine acetoacetone level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. urine ketone body amount male 105 days 0 91.5 umol/l 39.9 urine analysis 0.0 0 n=4-6 102916 2781
Slc:W urine 3-hydroxybutyrate level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. urine ketone body amount male 105 days 0 265.3 umol/l 11.7 urine analysis 0.0 0 n=4-6 102918 2781
LL/Mav timed urine volume vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine output male 112 days 9 12.4 ml/d 0.6 1.8 urine volume measurement method 0.0 0 102730 2721
LL/Mav urine total protein excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. total urine protein amount male 112 days 9 37.0 mg/d 1.0 3.0 urine protein analysis 0.0 0 102734 2721
LH/Mav urine albumin excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 11 24.0 mg/d 4.6 15.26 urine albumin analysis 0.0 0 102740 2721
LH/Mav urine albumin level to urine total protein level ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine albumin amount male 112 days 11 16.0 % 2.4 7.96 urine albumin analysis 0.0 0 102744 2721
LL/Mav urine creatinine excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine creatinine amount male 112 days 9 11.1 mg/d 0.5 1.5 urine creatinine analysis 0.0 0 102746 2721
SS-Nppbem2Mcwi-/- heart left ventricle end-diastolic posterior wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle posterior wall thickness male 168 days 7 1.89 mm 0.16 0.42 echocardiography 0.0 0 99776 2319
SS-Nppbem2Mcwi-/- heart left ventricle end-systolic diameter vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-systolic diameter male 252 days 7 4.67 mm 0.74 1.96 echocardiography 0.0 0 99790 2319
GK mean arterial blood pressure air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 147.0 mmHg 7.0 18.52 vascular transducer tipped catheter 0.0 0 103018 2784
GK mean arterial blood pressure air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 111.0 mmHg 5.0 13.23 vascular transducer tipped catheter 0.0 0 103022 2784
GK mean arterial blood pressure air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 123.0 mmHg 5.0 13.23 vascular transducer tipped catheter 0.0 0 103026 2784
Crlj:WI mean arterial blood pressure air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) then meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 6 undefined 155.0 mmHg 10.0 24.49 vascular transducer tipped catheter 0.0 0 103027 2784
Crlj:WI heart rate air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 379.0 beats/min 9.0 23.81 vascular transducer tipped catheter 0.0 0 103042 2784
GK heart rate air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 279.0 beats/min 17.0 44.98 vascular transducer tipped catheter 0.0 0 103054 2784
SS-Nppbem2Mcwi-/- body weight vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. body mass male 168 days 7 425.0 g 22.0 58.21 body weighing method 0.0 0 99758 2319
SS-Nppbem2Mcwi-/- heart interventricular end-diastolic septal wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart ventricle septum thickness male 84 days 7 2.01 mm 0.08 0.21 echocardiography 0.0 0 99762 2319
GK acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 67.1 % 3.32 9.39 wire myography 0.0 0 103592 2827
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -7.6 null 0.05 0.13 wire myography 0.0 0 103602 2827
GK acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 96.96 % 2.2 6.22 wire myography 0.0 0 103608 2827
GK sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 86.87 % 3.06 8.65 wire myography 0.0 0 103616 2827
OXYS/Nov neuron mitochondrion area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 3.6 % 0.1 0.2 ex vivo electron microscopy with digital image analysis 0.0 0 mito/cyto 103645 2844
WF/Mol heart left ventricle weight vehicle control condition then artificial aortocaval fistula (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart left ventricle mass male 0 days 8 0.24 g 0.01 0.01 post excision weight measurement 0.0 acf 2 days 101400 2585
WF/Mol heart left ventricle weight vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart left ventricle mass male 0 days 5 0.21 g 0.0 0.01 post excision weight measurement 0.0 sham acf 4 days 101405 2585
GK diastolic blood pressure vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 98.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103544 2827
WKY/NCrl heart rate vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 168 days 6 294.0 beats/min 5.0 12.25 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103558 2827
MW body weight unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. body mass male 0 days 7 220.0 g 9.0 23.81 body measuring method 0.0 unx 14 days 101142 2581
MW mean arterial blood pressure unilateral nephrectomy (for 70 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 7 undefined 108.0 mmHg 2.0 5.29 vascular indwelling catheter method 0.0 unx 70 days 101173 2581
GK serum fructosamine level vehicle control condition (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood fructosamine amount male 175 days 6 187.0 umol/l 9.0 22.05 serum fructosamine analysis 0.0 0 103504 2827
GK systolic blood pressure vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 145.0 mmHg 4.0 9.8 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103528 2827
WKY hematocrit unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. erythrocyte quantity male 0 days 17 44.8 % 0.6 2.47 hematocrit analysis 0.0 unx 168 days 99976 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 11 11.66 ml/d 1.01 3.34 metabolic cage urine volume measurement method 0.0 unx 168 days 100000 2378
SS/NEisSlc systolic blood pressure controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. arterial blood pressure trait male 126 days 8 undefined 226.0 mmHg 11.0 31.11 tail cuff plethysmography 0.0 0 102314 2684
SS/NEisSlc heart left ventricle fractional shortening controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days) Ishikawa M, et al., Int Heart J. 2013;54(2):98-106. heart left ventricle end-diastolic diameter male 126 days 8 24.8 % 1.2 3.39 transthoracic echocardiography 0.0 0 102317 2684
SD heart left ventricle weight to body weight ratio artificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart left ventricle mass male 0 days 6 g/g*103 2.6 mg/g 0.1 0.24 post excision weight measurement 1.0 ACF 2 days 98874 2160
LH/Mav blood glucose level vehicle control condition then fasting (for 16 hours) then glucose (2 g/kg) (for 1 hours) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood glucose amount male 49 days-56 days 8 121.0 mg/dl 6.0 16.97 blood glucose analysis 0.0 0 102660 2703
SS.ZUC-Leprfa-/-/Slc retroperitoneal fat pad weight to tibia length ratio vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. retroperitoneal fat pad mass male 91 days 13 429.56 mg/mm 13.64 49.18 post excision weight measurement 0.0 0 rf/tl 101980 2644
SS.ZUC-Leprfa-/-/Slc epididymal fat pad weight to tibia length ratio vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. epididymal fat pad mass male 91 days 13 3.55 g/cm 0.1 0.35 post excision weight measurement 0.0 0 ef/tl 101983 2644
SS.ZUC-Leprfa-/-/Slc mesenteric fat pad weight to tibia length ratio vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. mesenteric fat pad mass male 91 days 13 364.22 mg/mm 10.33 37.25 post excision weight measurement 0.0 0 mf/tl 101986 2644
WKY body weight vehicle control condition (1 null) Liu CX, etal., Mol Med. 2011 Jan-Feb;17(1-2):59-69. doi: 10.2119/molmed.2010.00111. Epub 2010 Sep 14. body mass male 156 days 10 450.39 g 9.36 29.6 body weighing method 0.0 0 99107 2219
LH/Mav systolic blood pressure vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. arterial blood pressure trait male 49 days-56 days 8 undefined 136.0 mmHg 3.0 8.49 tail cuff plethysmography 0.0 0 102645 2703
WF/Mol heart rate vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 6 448.0 beats/min 7.0 17.15 tail cuff plethysmography 0.0 acf 7 days 101387 2585
WKY right kidney wet weight left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. kidney mass male 238 days-252 days 15 1.35 g 0.04 0.17 post excision weight measurement 0.0 lad occlusion 196 days 100373 2460
WKY kidney fibrotic lesion area to total kidney area ratio left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. kidney integrity trait male 238 days-252 days 15 0.75 % 0.13 0.5 ex vivo light microscopy with histochemistry and digital image analysis 0.0 lad occlusion 196 days 100385 2460
WKY artery tunica media width to artery inner diameter ratio left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. kidney blood vessel morphology trait male 238 days-252 days 15 1.82 null 0.15 0.58 ex vivo light microscopy with histochemistry and digital image analysis 0.0 lad occlusion 196 days 100388 2460
LH/Mav urine total protein excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. total urine protein amount male 56 days 11 70.0 mg/d 9.0 29.85 urine protein analysis 0.0 0 102712 2721
SS-Nppbem2Mcwi-/- systolic blood pressure vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. arterial blood pressure trait male 252 days 7 serial mean 197.0 mmHg 26.0 68.79 tail cuff plethysmography 0.0 0 99832 2319
SS-Nppbem2Mcwi-/- timed urine volume vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. urine output male 84 days 7 14.7 ml/d 2.6 6.88 urine volume measurement method 0.0 0 99840 2319
WKY/NHsd skin chloride level to skin dry weight ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin chloride amount male 0 days 7 0.07 mmol/g 0.01 0.02 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin cl mmol/g 99137 2238
WKY/NHsd skin potassium level to skin water level ratio standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin potassium amount male 0 days 7 80.0 mmol/l 1.1 2.91 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin k/h2o 99155 2238
WKY/NHsd skin potassium level to skin water level ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin potassium amount male 0 days 7 71.0 mmol/l 3.0 7.94 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin k/h2o 99157 2238
WKY/NHsd plasma potassium level standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood potassium amount male 0 days 7 3.9 mmol/l 0.2 0.53 automated blood electrolyte analysis 0.0 0 99163 2238
WKY/NHsd plasma creatinine level controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood creatinine amount male 0 days 7 0.3 mg/dl 0.01 0.02 plasma creatinine analysis 0.0 0 99173 2238
SD-Nfe2l2em1Mcwi+/+ middle cerebral artery inner diameter controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. cerebral artery size trait male 9 days-11 days 5 246.0 um 4.8 10.73 ex vivo method 0.0 0 max dilation 100745 2520
SD-Nfe2l2em1Mcwi-/- middle cerebral artery inner diameter controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) then physiological salt solution perfusate Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. cerebral artery size trait male 9 days-11 days 4 154.0 um 15.0 30.0 ex vivo method 0.0 0 resting diameter 100752 2520
SHRSP/Gcrc timed urine volume vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine output male 126 days 17 55.29 ml/d 15.78 65.06 metabolic cage urine volume measurement method 0.0 0 102131 2646
SS.ZUC-Leprfa-/-/Slc tibia straight segment length bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. tibia length female 91 days 8 32.5 mm 0.9 2.55 body length measuring method 0.0 ovariectomy 42 days 101667 2622
SS.ZUC-Leprfa+/+/Slc heart left ventricle relative wall thickness bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle wall thickness female 91 days 9 44.0 % 2.0 6.0 echocardiography 0.0 ovariectomy 42 days 101727 2622
SS.ZUC-Leprfa-/-/Slc E wave deceleration time bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 8 56.9 ms 1.8 5.09 echocardiography 0.0 ovariectomy 42 days 101733 2622
SS.ZUC-Leprfa+/+/Slc heart isovolumetric relaxation time bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart muscle relaxation trait female 91 days 9 24.8 ms 1.8 5.4 echocardiography 0.0 ovariectomy 42 days 101735 2622
SS.ZUC-Leprfa-/-/Slc heart isovolumetric relaxation time bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart muscle relaxation trait female 91 days 8 43.1 ms 1.5 4.24 echocardiography 0.0 ovariectomy 42 days 101737 2622
SS.ZUC-Leprfa+/+/Slc time constant of left ventricular pressure decay bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricular blood pressure trait female 91 days 9 36.2 ms 0.5 1.5 echocardiography 0.0 ovariectomy 42 days 101747 2622
WF/Mol body weight vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 8 193.0 g 2.0 5.66 body weighing method 0.0 acf 7 days 101320 2585
WKY heart left ventricle end-systolic diameter left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle end-systolic diameter male 238 days-252 days 30 8.9 mm 0.2 1.1 echocardiography 0.0 lad occlusion 196 days 100344 2460
WKY heart posterior wall thickness left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle posterior wall thickness male 238 days-252 days 30 0.18 cm 0.0 0.02 echocardiography 0.0 lad occlusion 196 days 100347 2460
WKY/NHsd creatinine clearance standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. glomerular filtration trait male 0 days 7 3.1 ml/min 0.5 1.32 urine creatinine analysis 0.0 0 99179 2238
WKY/Gcrc urine sodium level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine sodium amount male 126 days 18 220.23 mmol/l 71.19 302.03 urine sodium analysis 0.0 0 102137 2646
SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc urine urea level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 9 228.93 mmol/l 62.26 186.78 urine urea analysis 0.0 0 102148 2646
SHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrc urine urea level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 6 103.0 mmol/l 34.23 83.85 urine urea analysis 0.0 0 102150 2646
WKY/NHsd skin sodium level to skin dry weight ratio standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin sodium amount male 0 days 7 0.11 REQUEST NEW VALUE 0.0 0.01 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin mmol/g 99131 2238
WKY/NHsd plasma chloride level controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood chloride amount male 0 days 7 104.8 mmol/l 1.8 4.76 automated blood electrolyte analysis 0.0 0 99169 2238
SS.ZUC-Leprfa-/-/Slc serum total cholesterol level vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood cholesterol amount male 91 days 6 333.0 mg/dl 15.6 38.21 serum total cholesterol measurement test 0.0 0 101941 2644
SS.ZUC-Leprfa-/-/Slc serum high density lipoprotein cholesterol level vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood HDL cholesterol amount male 91 days 6 97.25 mg/dl 15.33 37.55 serum high-density lipoprotein-cholesterol measurement test 0.0 0 101947 2644
SS.ZUC-Leprfa-/-/Slc heart left ventricle relative wall thickness vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricle wall thickness male 91 days 13 49.0 % 1.0 3.61 echocardiography 0.0 0 102004 2644
SS.ZUC-Leprfa-/-/Slc left ventricular end-diastolic blood pressure vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricular blood pressure trait male 91 days 13 17.65 mmHg 1.43 5.16 vascular transducer tipped catheter 0.0 0 102022 2644
SS.ZUC-Leprfa-/-/Slc heart left ventricular end-diastolic blood pressure to heart left ventricular end-diastolic diameter ratio vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricular blood pressure trait male 91 days 13 2.1 mmHg/mm 0.13 0.47 vascular transducer tipped catheter 0.0 0 102025 2644
SS-Sod3m1Mcwi heart left ventricle weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left ventricle mass male 56 days 10 0.64 g 0.01 0.03 post excision weight measurement 0.0 0 106539 3032
SS-Sod3m1Mcwi heart right ventricle weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56 days 10 0.16 g 0.0 0.01 post excision weight measurement 0.0 0 106541 3032
SS/JrHsdMcwi body weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. body mass male 56 days 7 261.0 g 6.0 15.87 body weighing method 0.0 0 106550 3032
SS/JrHsdMcwi right atrium weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56 days 7 0.02 g 0.0 0.0 post excision weight measurement 0.0 0 106562 3032
SS/JrHsdMcwi heart right atrium weight to left atrium weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56 days 7 1.09 null 0.09 0.24 post excision weight measurement 0.0 0 106570 3032
SS/JrHsdMcwi heart right ventricle weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56 days 7 0.62 mg/g 0.03 0.08 post excision weight measurement 0.0 0 106582 3032
SS-Sod3m1Mcwi lung weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56 days 10 0.47 % 0.01 0.02 post excision weight measurement 0.0 0 106591 3032
SS-Sod3m1Mcwi liver weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56 days 10 40.9 g/kg 0.77 2.43 post excision weight measurement 0.0 0 106603 3032
SS-Sod3m1Mcwi heart right ventricle weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56 days 10 4.33 mg/mm 0.97 3.07 post excision weight measurement 0.0 0 106611 3032
SS/JrHsdMcwi lung weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56 days 7 0.29 g/cm 0.05 0.12 post excision weight measurement 0.0 0 106618 3032
F344-Pde4dTn(sb-T2/Bart3)2.285Mcwi cerebrum infarct volume to total cerebrum volume ratio isoflurane (1.5 %) (for 4 hours) then vehicle control condition then middle cerebral artery occlusion (for 1 hours) Yang F, et al., J Pharm Pharm Sci. 2014;17(3):362-70. cerebrum integrity trait male 0 days 6 20.0 % 9.0 22.05 ex vivo light microscopy with histochemistry and digital image analysis 0.0 cerebral ischemia 1 days 106360 3029
SS-Sod3m1Mcwi heart left atrium weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left atrium mass male 56 days 10 0.45 mg/mm 0.03 0.09 post excision weight measurement 0.0 0 106627 3032
SD-Ahrem2Sage liver weight as percentage of body weight vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. liver mass female 84 days 10 3.43 % 0.3 0.95 post excision weight measurement 0.0 0 105726 3021
Hsd:SD thymus weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. thymus mass female 84 days 10 1.5 mg/g 0.35 1.11 post excision weight measurement 0 105884 3021
SD-Ahrem2Sage thymus weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. thymus mass female 84 days 10 1.61 mg/g 0.19 0.6 post excision weight measurement 0 105885 3021
SD-Ahrem2Sage both ovaries weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. ovary mass female 84 days 10 0.05 % 0.01 0.02 post excision weight measurement 0 105921 3021
Hsd:SD blood neutrophil count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. neutrophil quantity female 84 days 10 1.48 x 1000 cells/ul 0.85 2.69 automated hematology analysis 0 106028 3021
SD-Ahrem2Sage blood basophil count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. basophil quantity female 84 days 10 0.08 x 1000 cells/ul 0.02 0.06 automated hematology analysis 0 106077 3021
Hsd:SD hematocrit vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 43.31 % 1.49 4.71 automated hematology analysis 0 105956 3021
SD-Ahrem2Sage mean corpuscular volume vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte size trait female 84 days 10 58.44 fl 0.87 2.75 automated hematology analysis 0 105969 3021
Hsd:SD mean corpuscular hemoglobin concentration vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 32.48 g/dl 0.68 2.15 automated hematology analysis 0 105992 3021
SD-Ahrem2Sage platelet count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. platelet quantity female 84 days 10 1388.0 x 1000 cells/ul 216.06 683.24 automated hematology analysis 0 106005 3021
SD serum interleukin-9 level vehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days) Zhuang ZM, et al., Int J Clin Exp Med. 2015 May 15;8(5):6866-77. eCollection 2015. blood interleukin-9 amount not specified 0 days 4 0.1 ug/l 0.01 0.01 enzyme linked immunosorbent assay 0.0 0 error not defined 105415 3015
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 5 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 59 days-66 days 5 131.6 um 4.87 10.9 optical coherence tomography 0.0 0 optical coherence tomography inner retinal layer 105470 3016
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67 days-74 days 5 128.7 um 4.92 11.0 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography inner retinal layer 105478 3016
ISIAH thymus weight to body weight ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymus mass male 150 days-180 days 10 1.95 mg/g 0.77 2.43 post excision weight measurement 0.0 IP injeciton 1 days saline 107689 3096
SHRSP/A3NCrl creatinine clearance controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. glomerular filtration trait male 161 days-175 days 6 2.0 ml/min 0.2 0.49 urine creatinine analysis 0.0 0 107388 3083
SHRSP/A3NCrl blood urea nitrogen level controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. blood urea nitrogen amount male 161 days-175 days 6 20.5 mg/dl 5.8 14.21 blood urea nitrogen analysis 0.0 0 107391 3083
SS/NEisSlc neuron count vehicle control condition (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. hippocampus neuron quantity not specified 547 days 10 1258.0 cells/mm2 32.0 101.19 ex vivo light microscopy with histochemistry 0.0 0 107465 2339
SS/JrHsdMcwi heart rate vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart pumping trait male 56 days 6 358.0 beats/min 7.95 19.47 vascular fluid filled catheter 0.0 0 106798 3032
SS-Sod3m1Mcwi systolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56 days 8 115.0 mmHg 5.22 14.76 vascular fluid filled catheter 0.0 0 106803 3032
SS-Sod3m1Mcwi diastolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56 days 8 84.2 mmHg 4.96 14.03 vascular fluid filled catheter 0.0 0 106807 3032
SS-Sod3m1Mcwi mean aortic pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56 days 8 94.5 mmHg 5.02 14.2 vascular fluid filled catheter 0.0 0 Mean aortic pressure 106811 3032
SS/NEisSlc heart weight to body weight ratio vehicle control condition (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. heart mass not specified 547 days 10 3.2 g/kg 0.1 0.32 post excision weight measurement 0.0 0 106792 2339
Crl:WI timed urine volume vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. urine output male 114 days 10 11.1 ml/d 1.3 4.11 metabolic cage urine volume measurement method 0.0 0 109399 3140
MWF/FubRkb systolic blood pressure vehicle control condition (10 mg/kg/d) (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. arterial blood pressure trait male 112 days 10 151.5 mmHg 9.0 28.46 tail cuff plethysmography 0.0 0 109409 3140
Crl:WI heart rate vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. heart pumping trait male 112 days 10 355.3 beats/min 9.7 30.67 tail cuff plethysmography heart 0.0 0 109411 3140
MWF/FubRkb heart rate vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. heart pumping trait male 112 days 10 352.3 beats/min 7.3 23.08 tail cuff plethysmography heart 0.0 0 109413 3140
MWF/FubRkb mesenteric artery adventitial thickness vehicle control condition Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. mesenteric artery morphology trait male 114 days 10 8.6 um 0.7 2.21 confocal microscopy 0.0 0 109425 3140
Crl:WI mesenteric artery media thickness vehicle control condition Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. mesenteric artery morphology trait male 114 days 10 18.5 um 0.8 2.53 confocal microscopy 0.0 0 109427 3140
Crl:WI acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasodilation trait male 114 days 10 90.3 % 1.2 3.79 wire myography mesenteric artery 0.0 0 109431 3140
WAG/Nov apoptotic hypodiploid thymocyte count to total thymocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. T cell development trait male 150 days-180 days 10 0.45 % 0.12 0.38 flow cytometry method 0.0 IP injection 1 days saline 107706 3096
WAG/Nov G0 stage diploid thymocyte count to total thymocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. T cell development trait male 150 days-180 days 10 93.31 % 0.93 2.94 flow cytometry method 0.0 IP injection 1 days saline 107709 3096
Crl:WI body weight vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. body mass male 112 days 10 391.8 g 17.2 54.39 body weighing method 0.0 0 109387 3140
WKY body weight unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 17 256.0 g 5.0 20.62 body weighing method 0.0 unx 150 days 107446 2378
WKY kidney glomerular surface area unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 17 19.3 x 10E3 um2 4.8 19.79 ex vivo light microscopy with histochemistry 0.0 unx 150 days kidney glomerulus surface area (CMO:0003488) 107461 2378
BDIX/CrCrl platelet distribution width DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. platelet size trait male 71 days 10 8.7 fl 0.16 0.5 automated hematology analysis 0.0 0 107882 3097
WAG/Nov CD4+CD25- splenocyte count to total splenocyte count ratio vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 27.9 % 0.69 2.18 flow cytometry method 0.0 IP injeciton 1 days saline cd4+cd25- spleen 107730 3096
ISIAH CD4-CD25+ splenocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 3.21 x 10E6/organ 0.57 1.8 flow cytometry method 0.0 IP injeciton 1 days saline cd4-cd25+ spleen 107754 3096
ISIAH CD11b/c+ splenocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. splenocyte morphology trait male 150 days-180 days 10 50.17 x10E6/organ 10.65 33.68 flow cytometry method 0.0 IP injeciton 1 days saline cd11b/c+ spleen 107760 3096
WAG/Nov plasma triglyceride level vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. blood triglyceride amount male 150 days-180 days 10 1.19 mmol/l 0.09 0.29 plasma triglyceride analysis 0.0 IP injeciton 1 days saline 107775 3096
ISIAH plasma triglyceride level vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. blood triglyceride amount male 150 days-180 days 10 1.3 mmol/l 0.12 0.36 plasma triglyceride analysis 0.0 IP injeciton 1 days saline 107778 3096
WAG/Nov plasma high density lipoprotein phospholipid level vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. blood HDL phospholipid amount male 150 days-180 days 10 47.1 mg/dl 4.1 12.97 plasma high-density lipoprotein-cholesterol measurement test 0.0 IP injeciton 1 days saline 107787 3096
ISIAH plasma high density lipoprotein phospholipid level vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. blood HDL phospholipid amount male 150 days-180 days 10 36.2 mg/dl 2.4 7.59 plasma high-density lipoprotein-cholesterol measurement test 0.0 IP injeciton 1 days saline 107790 3096
BDIX/CrCrl mean platelet volume DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. platelet size trait male 71 days 10 5.9 fl 0.03 0.1 automated hematology analysis 0.0 0 107821 3097
BDIX/CrCrl mean platelet volume DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. platelet size trait male 92 days 10 5.9 fl 0.06 0.2 automated hematology analysis 0.0 0 107823 3097
BDIX/CrCrl mean corpuscular hemoglobin DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood hemoglobin amount male 71 days 10 18.0 pg 0.06 0.2 blood hemoglobin analysis 0.0 0 hemoglobin, MCH, MCHC 107836 3097
WKY heart weight to body weight ratio unilateral nephrectomy (for 150 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. heart mass male 0 days 11 2.4 g/kg 0.1 0.33 post excision weight measurement 0.0 unx 150 days 107450 2378
SS/NEisSlc serum NAG activity level vehicle control condition (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. blood enzyme amount not specified 547 days 10 20.1 uU/ml 1.9 6.01 blood NAG activity assay 0.0 0 blood NAG activity assay (MMO:0000723) serum NAG activity level (CMO:0003487) 107425 2339
BDIX/CrCrl serum lactate dehydrogenase activity level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood lactate dehydrogenase amount male 71 days 10 964.0 U/l 31.31 99.0 automated serum analysis 0.0 0 107929 3097
RCS/LavRrrc scotopic B wave amplitude of ERG waveform vehicle control condition (2 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus Huang L, et al., Stem Cell Res Ther. 2017 Dec 22;8(1):290. doi: 10.1186/s13287-017-0731-y. rod electrophysiology trait not specified 77 days 4 13.01 uV 1.85 3.69 electroretinography retina 0.0 pbs vehicle injection 56 days 109862 3157
BDIX/CrCrl serum triglyceride level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood triglyceride amount male 71 days 10 265.0 mg/dl 8.22 26.0 automated serum analysis 0.0 0 serum triglyceride level 107897 3097
BDIX/CrCrl blood granulocyte count to total leukocyte count ratio DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. granulocyte quantity male 71 days 10 1.2 % 0.0 0.0 automated differential white blood cell count test 0.0 0 107856 3097
SHRSP/A3N interstitial nephritis foci count controlled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days) Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21. kidney integrity trait male 126 days-182 days 0 8.5 /section 1.2 ex vivo light microscopy with histochemistry 0.0 0 107551 3090
WKY kidney glomerular tuft surface area unilateral nephrectomy (for 150 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. kidney glomerulus size trait male 0 days 11 8.7 x 10E3 um2 2.6 8.62 ex vivo light microscopy with histochemistry 0.0 unx 150 days 107510 2378
BDIX/CrCrl serum alanine aminotransferase activity level DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. blood alanine transaminase amount male 92 days 10 44.8 U/l 2.94 9.3 automated serum analysis 0.0 0 serum alanine aminotransferase 107909 3097
Hsd:WI spleen weight to body weight ratio vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. spleen mass male 119 days-126 days 5 0.18 % 0.01 0.02 post excision weight measurement 0.0 0 76120 1545
HanTac:WH gestation period length vehicle control condition (for 14 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. gestation period duration female 0 days 18 23.0 d 0.14 0.6 in vivo visual assessment 0.0 0 96583 1559
HanTac:WH left testis wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. testis mass male 16 days-17 days 18 50.9 mg 1.74 7.4 post excision weight measurement 0.0 0 96642 1559
BluHsd:LE food intake weight to change in body weight ratio controlled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. eating behavior trait male 71 days-98 days 8 4.7 g/g 0.2 0.57 unspecified method 0.0 0 76197 1543
Hsd:WI kidney lipid peroxide level vehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney lipid peroxide amount male 0 days 6 1.51 nmol/mg 0.03 0.08 liquid phase colorimetry 0.0 0 76257 1544
WKY timed urine volume left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. urine output male 238 days-252 days 7 10.6 ml/d 2.2 5.82 urine volume measurement method 0.0 lad occlusion 196 days 100362 2460
SS.ZUC-Leprfa-/-/Slc E wave deceleration time vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood flow trait male 91 days 13 53.05 ms 1.48 5.34 echocardiography 0.0 0 102013 2644
WKY/Gcrc heart weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart mass male 126 days 0 3.48 g/kg 0.26 post excision weight measurement 0.0 0 102101 2646
SS/JrHsdMcwi liver weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56 days 7 40.5 g/kg 1.02 2.7 post excision weight measurement 0.0 0 106602 3032
SS-Sod3m1Mcwi single kidney wet weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. kidney mass male 56 days 10 7.83 g/kg 0.15 0.47 post excision weight measurement 0.0 0 106607 3032
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 17 324.0 mg/dl 13.0 53.6 machine read blood glucose test strip 0.0 unx 168 days 99971 2378
WKY hematocrit unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. erythrocyte quantity male 0 days 11 45.2 % 1.4 4.64 hematocrit analysis 0.0 unx 168 days 99975 2378
MW systolic blood pressure unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. arterial blood pressure trait male 0 days 7 undefined 118.0 mmHg 2.0 5.29 tail cuff plethysmography 0.0 unx 42 days 101163 2581
MW blood urea nitrogen level unilateral nephrectomy (for 70 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. blood urea nitrogen amount male 0 days 7 26.0 mg/dl 1.0 2.65 blood urea nitrogen analysis 0.0 unx 70 days 101187 2581
MW urine total protein excretion rate unilateral nephrectomy (for 14 days) then vehicle control condition Fogo A, et al., J Clin Invest. 1988 Jul;82(1):322-30. total urine protein amount male 0 days 7 11.0 mg/d 2.0 5.29 Bradford protein assay 0.0 unx 14 days 101192 2581
SD heart rate artificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart pumping trait male 0 days 6 420.0 beats/min 14.0 34.29 HP Sonos 5500 echo ultrasound 1.0 ACF 2 days 98801 2160
LH/Mav heart left ventricle weight to body weight ratio vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. heart left ventricle mass male 112 days 11 2.24 mg/g 0.0 0.01 post excision weight measurement 0.0 0 102768 2721
WKY body weight left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. body mass male 238 days-252 days 30 617.0 g 52.0 284.82 body weighing method 0.0 lad occlusion 196 days 100272 2460
Hsd:SD blood basophil count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. basophil quantity female 84 days 10 0.07 x 1000 cells/ul 0.03 0.09 automated hematology analysis 0 106076 3021
BluHsd:LE both testes wet weight vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. testis mass male 98 days 8 3.4 g 0.3 0.85 post excision weight measurement 0.0 0 76233 1543
LH/MavRrrc both kidneys wet weight to body weight ratio vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. kidney mass male 112 days 8 6.36 g/kg 0.08 0.23 post excision weight measurement 0.0 0 102693 2703
SS.ZUC-Leprfa-/-/Slc heart left ventricle end-diastolic diameter vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricle end-diastolic diameter male 91 days 13 8.27 mm 0.13 0.47 echocardiography 0.0 0 101995 2644
LH/Mav blood glucose level vehicle control condition then fasting (for 16 hours) Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood glucose amount male 49 days-56 days 8 67.0 mg/dl 1.0 2.83 blood glucose analysis 0.0 0 102657 2703
LL/Mav systolic blood pressure vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. arterial blood pressure trait male 49 days-56 days 13 undefined 115.0 mmHg 3.0 10.82 tail cuff plethysmography 0.0 0 102644 2703
LH/Mav timed urine volume vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. urine output male 49 days-56 days 8 8.7 ml/d 0.6 1.7 urine volume measurement method 0.0 0 102648 2703
SD maximum rate of positive change in left ventricular blood pressure artificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart left ventricular blood pressure trait male 0 days 6 8259.0 mmHg/s 325.0 796.08 vascular transducer tipped catheter 1.0 ACF 2 days 98886 2160
Crlj:WI heart rate air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 6 351.0 beats/min 19.0 46.54 vascular transducer tipped catheter 0.0 0 103043 2784
GK heart rate air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 344.0 beats/min 11.0 29.1 vascular transducer tipped catheter 0.0 0 103050 2784
SHRSP/Gcrc urine urea level to urine creatinine level ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 17 112.69 null 29.95 123.49 urine urea analysis 0.0 0 103791 2646
WF/Mol heart right ventricle weight vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 8 0.07 g 0.0 0.01 post excision weight measurement 0.0 acf 4 days 101426 2585
WF/Mol body weight vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 6 201.0 g 3.0 7.35 body weighing method 0.0 7 days 101321 2585
WF/Mol body weight gain vehicle control condition then sham surgical control condition (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 6 -6.0 g 1.0 2.45 body weighing method 0.0 sham acf 2 days change from surgery weight 101335 2585
SD maximum rate of negative change in left ventricular blood pressure sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart left ventricular blood pressure trait male 0 days 6 -7197.0 mmHg/s 303.0 742.2 vascular transducer tipped catheter 1.0 sham ACF 2 days 98891 2160
WF/Mol heart right ventricle weight vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 7 0.1 g 0.0 0.01 post excision weight measurement 0.0 acf 7 days 101416 2585
WKY/NHsd skin chloride level to skin water level ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin chloride amount male 0 days 7 101.0 mmol/l 3.9 10.32 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin na/h2o 99149 2238
WKY/NHsd plasma potassium level controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood potassium amount male 0 days 7 4.2 mmol/l 0.3 0.79 automated blood electrolyte analysis 0.0 0 99165 2238
SS-Nppbem2Mcwi-/- heart left ventricle fractional shortening vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-diastolic diameter male 252 days 7 41.6 % 5.6 14.82 echocardiography 0.0 0 99808 2319
SHRSP.WKY-(D3Mgh16-rs197649383)/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 4.25 g/kg 0.7 post excision weight measurement 0.0 0 102124 2646
WKY/Gcrc water drink intake rate vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. drinking behavior trait male 126 days 18 53.12 ml/d 30.74 130.42 metabolic cage water drinking measurement method 0.0 0 102127 2646
WKY renal filtration fraction unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. glomerular filtration trait male 0 days 8 0.26 null 0.01 0.04 inulin analysis by liquid phase colorimetry 0.0 unx 28 days 99956 2378
WKY timed urine volume unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. urine output male 0 days 7 12.38 ml/d 2.02 5.33 metabolic cage urine volume measurement method 0.0 unx 28 days 99965 2378
WKY heart ventricle septal wall thickness left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. heart left ventricle wall thickness male 238 days-252 days 30 0.1 cm 0.0 0.02 echocardiography 0.0 lad occlusion 196 days 100338 2460
SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc urine urea level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 7 316.61 mmol/l 113.57 300.48 urine urea analysis 0.0 0 102149 2646
Hsd:WI serum total protein level vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. blood total protein amount male 119 days-126 days 5 9.38 g/dl 0.67 1.5 liquid phase colorimetry 0.0 0 76125 1545
HanTac:WH right ovary wet weight vehicle control condition (between 16 and 17 days) Christiansen S, et al., Reproduction. 2014 Mar 2;147(4):477-87. doi: 10.1530/REP-13-0377. Print 2014. ovary mass female 16 days-17 days 15 2.9 mg 0.2 0.77 post excision weight measurement 0.0 0 right ovary 96692 1559
BluHsd:LE both testes wet weight vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. testis mass male 98 days 8 3.4 g 0.2 0.57 post excision weight measurement 0.0 0 76249 1543
Hsd:WI serum calcium level vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. blood calcium amount male 119 days-126 days 5 12.82 mg/dl 0.24 0.53 liquid phase colorimetry 0.0 0 76141 1545
BluHsd:LE total food calorie intake rate vehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. eating behavior trait male 71 days-98 days 8 2103.7 kcal/d 62.9 177.91 unspecified method 0.0 0 76169 1543
BluHsd:LE food calorie intake level to change in body weight ratio controlled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) Nanjappa MK, et al., Toxicol Lett. 2014 Mar 21;225(3):479-87. doi: 10.1016/j.toxlet.2014.01.024. Epub 2014 Jan 26. eating behavior trait male 71 days-98 days 8 10.1 kcal/g 0.3 0.85 unspecified method 0.0 0 76204 1543
Hsd:WI timed urine volume vehicle control condition (for 10 days) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. urine output male 0 days 6 6.8 ml/d 0.61 1.5 urine volume measurement method 0.0 0 75965 1544
Hsd:WI body weight vehicle control condition (for 91 days) Yildiz N and Barlas N, Hum Exp Toxicol. 2013 Jul;32(7):675-86. doi: 10.1177/0960327112464796. body mass male 119 days-126 days 5 388.0 g 16.82 37.6 body weighing method 0.0 0 76041 1545
Hsd:WI both kidneys wet weight vehicle control condition (for 10 days) Prabhu VV, et al., Pharmacol Rep. 2013;65(4):980-90. kidney mass male 0 days 6 0.82 g 0.02 0.06 post excision weight measurement 0.0 0 75956 1544
LH/Mav body weight vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. body mass male 56 days 11 246.0 g 4.0 13.27 body weighing method 0.0 0 102700 2721
LH/Mav blood glucose level vehicle control condition then fasting (for 16 hours) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood glucose amount male 56 days 11 69.0 mg/dl 1.0 3.32 blood glucose analysis 0.0 0 102716 2721
LH/Mav timed urine volume vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. urine output male 112 days 11 11.6 ml/d 0.4 1.33 urine volume measurement method 0.0 0 102732 2721
LH/Mav urine total protein excretion rate vehicle control condition Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. total urine protein amount male 112 days 11 135.0 mg/d 21.0 69.65 urine protein analysis 0.0 0 102736 2721
GK/Slc blood hemoglobin A1c level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood hemoglobin amount male 105 days 0 5.21 % 0.12 blood hemoglobin analysis 0.0 0 HbA1c n=4-6 102880 2781
Slc:W blood total cholesterol level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. blood cholesterol amount male 105 days 0 67.0 mg/dl 3.5 blood cholesterol analysis 0.0 0 n=4-6 102890 2781
Slc:W timed urine volume vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. urine output male 105 days 0 11.2 ml/d 0.5 urine volume measurement method 0.0 0 n=4-6 102922 2781
GK/Slc urine glucose level vehicle control condition (for 21 days) Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. urine glucose amount male 105 days 0 588.3 mg/dl 349.4 blood glucose test strip read by electrochemical glucometer 0.0 0 n=4-6 102928 2781
SHRSP.WKY-(D3Mgh16-D3Wox3)/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 7 3.77 g/kg 0.15 0.4 post excision weight measurement 0.0 0 102161 2646
SHRSP.WKY-(D3Mgh16-D3Rat80)/Gcrc heart left ventricle weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. heart left ventricle mass male 126 days 0 2.79 mg/g 0.14 post excision weight measurement 0.0 0 102113 2646
WKY/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 2.87 g/kg 0.23 post excision weight measurement 0.0 0 102119 2646
SHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrc both kidneys wet weight to body weight ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. kidney mass male 126 days 0 3.65 g/kg 0.2 post excision weight measurement 0.0 0 102120 2646
GK systolic blood pressure vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 145.0 mmHg 4.0 9.8 intra-aortic abdominal radiotelemetry 0 measured 12 hr/night for 4 weeks nighttime measurement 103536 2827
WKY/NCrl number of spontaneous locomotor movements per unit time vehicle control condition (between 1 and 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. voluntary movement trait male 168 days 6 0.9 /min 0.1 0.24 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks number of spontaneous locomotor movements per unit time (CMO:0003644) 103574 2827
SS-Nppbem2Mcwi-/- heart interventricular end-diastolic septal wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart ventricle septum thickness male 168 days 7 1.92 mm 0.12 0.32 echocardiography 0.0 0 99764 2319
SS-Nppbem2Mcwi-/- heart interventricular end-diastolic septal wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart ventricle septum thickness male 252 days 7 2.26 mm 0.23 0.61 echocardiography 0.0 0 99766 2319
SS-Nppbem2Mcwi-/- heart left ventricle end-systolic diameter vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-systolic diameter male 84 days 7 3.98 mm 0.45 1.19 echocardiography 0.0 0 99786 2319
SS-Nppbem2Mcwi-/- heart left ventricle end-systolic diameter vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle end-systolic diameter male 168 days 7 4.83 mm 0.35 0.93 echocardiography 0.0 0 99788 2319
GK mean arterial blood pressure air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 5 undefined 137.0 mmHg 6.0 13.42 vascular transducer tipped catheter 0.0 0 103017 2784
GK mean arterial blood pressure air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 5 undefined 151.0 mmHg 1.0 2.24 vascular transducer tipped catheter 0.0 0 103029 2784
GK mean arterial blood pressure air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 5 undefined 137.0 mmHg 3.0 6.71 vascular transducer tipped catheter 0.0 0 103033 2784
Crlj:WI heart rate air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 6 90.0 beats/min 15.0 36.74 vascular transducer tipped catheter 0.0 0 103039 2784
GK heart rate air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 5 366.0 beats/min 17.0 38.01 vascular transducer tipped catheter 0.0 0 103045 2784
WKY/NCrl body weight vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. body mass male 168 days 6 463.0 g 7.0 17.15 body weighing method 0.0 0 103490 2827
WKY/NCrl serum fructosamine level vehicle control condition (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood fructosamine amount male 175 days 6 153.0 umol/l 3.0 7.35 serum fructosamine analysis 0.0 0 103502 2827
WKY/NCrl blood glucose level vehicle control condition (for 28 days) then fasting (for 16 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood glucose amount male 168 days 6 113.0 mg/dl 4.0 9.8 blood glucose test strip read by electrochemical glucometer 0.0 0 103510 2827
WKY/NCrl systolic blood pressure vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168 days 6 121.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry 0 measured 12 hr/day for 4 weeks daytime measurement 103526 2827
WF/Mol body weight gain vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 6 8.0 g 2.0 4.9 body weighing method 0.0 acf 7 days change from surgery weight 101342 2585
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -7.07 null 0.05 0.14 wire myography 0 103586 2827
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 -8.15 null 0.09 0.24 wire myography 0.0 0 103610 2827
GK logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 8 -8.74 null 0.57 1.61 wire myography 0.0 0 103612 2827
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168 days 7 96.54 % 1.9 5.03 wire myography 0.0 0 103614 2827
WKY/NCrl mesenteric artery phosphorylated eNOS level to total eNOS level ratio vehicle control condition (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. artery molecular composition trait male 175 days 7 0.94 null 0.13 0.34 western blot assay 0.0 0 103622 2827
WI neuron mitochondrion area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 10.4 % 0.16 0.32 ex vivo electron microscopy with digital image analysis 0.0 0 mito/cyto 103644 2844
WI neuron rough endoplasmic reticulum area to neuron cytoplasm area ratio vehicle control condition (for 180 days) Stefanova NA, et al., J Pineal Res. 2015 Sep;59(2):163-77. doi: 10.1111/jpi.12248. Epub 2015 Jun 8. neuron morphology trait male 547 days 4 27.4 % 0.51 1.02 ex vivo electron microscopy with digital image analysis 0.0 0 rer/cyto 103653 2844
SS-Nppbem2Mcwi-/- body weight vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. body mass male 252 days 7 452.0 g 21.0 55.56 body weighing method 0.0 0 99760 2319
SD serum creatinine level controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days) Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. blood creatinine amount female 0 days 13 1.65 mg/dl 0.14 0.5 serum creatinine analysis 0.0 unx 97 days 100637 2499
WF/Mol systolic blood pressure vehicle control condition then artificial aortocaval fistula (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. arterial blood pressure trait male 0 days 7 undefined 116.0 mmHg 4.0 10.58 tail cuff plethysmography 0.0 acf 7 days 101350 2585
WF/Mol systolic blood pressure vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. arterial blood pressure trait male 0 days 5 undefined 130.0 mmHg 2.0 4.47 tail cuff plethysmography 0.0 sham acf 7 days 101351 2585
WF/Mol heart rate vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 6 460.0 beats/min 9.0 22.05 tail cuff plethysmography 0.0 acf 4 days 101368 2585
WF/Mol heart rate vehicle control condition then sham surgical control condition (for 7 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 5 358.0 beats/min 12.0 26.83 tail cuff plethysmography 0.0 sham acf 7 days 101373 2585
WF/Mol heart left ventricle weight vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart left ventricle mass male 0 days 8 0.26 g 0.01 0.01 post excision weight measurement 0.0 acf 4 days 101404 2585
LL/Mav body weight vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. body mass male 49 days-56 days 13 219.0 g 5.0 18.03 body weighing method 0.0 0 102641 2703
LL/Mav blood glucose level vehicle control condition then fasting (for 16 hours) Emonnot L, et al., J Hypertens. 2007 Feb;25(2):429-38. blood glucose amount male 56 days 9 70.0 mg/dl 1.0 3.0 blood glucose analysis 0.0 0 102714 2721
SS-Nppbem2Mcwi-/- systolic blood pressure vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. arterial blood pressure trait male 168 days 7 serial mean 195.0 mmHg 30.0 79.37 tail cuff plethysmography 0.0 0 99830 2319
SS-Nppbem2Mcwi-/- timed urine volume vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. urine output male 252 days 7 19.5 ml/d 4.6 12.17 urine volume measurement method 0.0 0 99844 2319
WKY/Gcrc urine urea level to urine creatinine level ratio vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine urea amount male 126 days 18 68.85 null 9.11 38.65 urine urea analysis 0.0 0 103792 2646
LH/Mav plasma total cholesterol level vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. blood cholesterol amount male 112 days 8 66.41 mg/dl 5.41 15.29 blood cholesterol analysis 0.0 0 102663 2703
LL/Mav heart left ventricle weight to body weight ratio vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. heart left ventricle mass male 112 days 13 20.4 mg/g 0.1 0.36 post excision weight measurement 0.0 0 102680 2703
LL/Mav aorta weight to body weight ratio vehicle control condition Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3. aorta mass male 112 days 13 11.6 mg/100g 0.3 1.08 post excision weight measurement 0.0 0 102686 2703
WF/Mol heart left ventricle weight vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart left ventricle mass male 0 days 7 0.28 g 0.0 0.01 post excision weight measurement 0.0 acf 4 days 101390 2585
SS.ZUC-Leprfa-/-/Slc heart ventricle septal wall thickness bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle wall thickness female 91 days 8 0.21 cm 0.0 0.01 echocardiography 0.0 ovariectomy 42 days 101709 2622
SD left ventricular end-systolic blood pressure sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) Seqqat R, et al., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15. heart left ventricular blood pressure trait male 0 days 6 64.0 mmHg 3.0 7.35 vascular transducer tipped catheter 1.0 sham ACF 2 days 98839 2160
WKY timed urine volume left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days) Rokutan H, et al., Int J Cardiol. 2012 Sep 20;160(1):20-5. doi: 10.1016/j.ijcard.2011.03.005. Epub 2011 Mar 29. urine output male 238 days-252 days 7 10.6 ml/d 2.2 5.82 urine volume measurement method 0.0 lad occlusion 196 days 100376 2460
WF/Mol heart rate vehicle control condition then artificial aortocaval fistula (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart pumping trait male 0 days 6 448.0 beats/min 10.0 24.49 tail cuff plethysmography 0.0 acf 4 days 101382 2585
WF/Mol body weight gain vehicle control condition then artificial aortocaval fistula (for 2 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. body mass male 0 days 7 -14.0 g 2.0 5.29 body weighing method 0.0 acf 2 days change from surgery weight 101334 2585
SS-Nppbem2Mcwi-/- heart left ventricle end-systolic posterior wall thickness vehicle control condition Holditch SJ, et al., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11. heart left ventricle posterior wall thickness male 168 days 7 3.17 mm 0.17 0.45 echocardiography 0.0 0 99794 2319
SS.ZUC-Leprfa-/-/Slc systolic blood pressure bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. arterial blood pressure trait female 91 days 8 undefined 221.0 mmHg 5.0 14.14 tail cuff plethysmography 0.0 ovariectomy 42 days 101671 2622
SS.ZUC-Leprfa+/+/Slc heart left ventricle posterior wall thickness bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle posterior wall thickness female 91 days 9 1.5 mm 0.02 0.06 echocardiography 0.0 ovariectomy 42 days 101711 2622
SS.ZUC-Leprfa-/-/Slc heart left ventricle posterior wall thickness bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle posterior wall thickness female 91 days 8 2.06 mm 0.04 0.11 echocardiography 0.0 ovariectomy 42 days 101713 2622
SS.ZUC-Leprfa+/+/Slc heart left ventricle end-diastolic diameter bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle end-diastolic diameter female 91 days 9 7.21 mm 0.21 0.63 echocardiography 0.0 ovariectomy 42 days 101715 2622
SS.ZUC-Leprfa-/-/Slc heart left ventricle end-diastolic diameter bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle end-diastolic diameter female 91 days 8 7.2 mm 0.14 0.4 echocardiography 0.0 ovariectomy 42 days 101717 2622
SS.ZUC-Leprfa-/-/Slc calculated heart left ventricle weight bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle mass female 91 days 8 1114.0 mg 35.0 98.99 echocardiography 0.0 ovariectomy 42 days 101725 2622
SS.ZUC-Leprfa-/-/Slc heart left ventricle relative wall thickness bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle wall thickness female 91 days 8 57.0 % 2.0 5.66 echocardiography 0.0 ovariectomy 42 days 101729 2622
SS.ZUC-Leprfa+/+/Slc myocardial performance index bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 9 0.44 null 0.01 0.03 echocardiography 0.0 ovariectomy 42 days 101739 2622
WKY/NHsd skin chloride level to skin water level ratio controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. skin chloride amount male 0 days 7 48.0 mmol/l 4.8 12.7 ex vivo analysis of atomic composition following dry ashing 0.0 0 ashed skin skin cl/h2o 99153 2238
WKY/NHsd plasma sodium level controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. blood sodium amount male 0 days 7 141.4 mmol/l 2.1 5.56 automated blood electrolyte analysis 0.0 0 99161 2238
MWF/ZtmRrrc body weight vehicle control condition Remuzzi A, et al., J Clin Invest. 1990 Feb;85(2):541-9. body mass male 126 days 8 378.0 g 10.61 30.0 body weighing method 0.0 0 100901 2541
MWF/ZtmRrrc body weight vehicle control condition Remuzzi A, et al., J Clin Invest. 1990 Feb;85(2):541-9. body mass male 126 days 7 385.0 g 11.34 30.0 body weighing method 0.0 0 100903 2541
WF/Mol heart right ventricle weight vehicle control condition then sham surgical control condition (for 4 days) Wahlander H, et al., Acta Physiol Scand. 1999 Feb;165(2):143-54. heart right ventricle mass male 0 days 5 0.05 g 0.0 0.0 post excision weight measurement 0.0 sham acf 4 days 101427 2585
WKY body weight unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. body mass male 0 days 7 268.0 g 13.0 34.39 body weighing method 0.0 unx 28 days 99935 2378
WKY blood glucose level unilateral nephrectomy (for 28 days) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 7 74.0 mg/dl 2.0 5.29 machine read blood glucose test strip 0.0 unx 28 days 99940 2378
WKY blood glucose level unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition Ding SS, et al., J Cardiovasc Pharmacol. 2003 Jul;42(1):48-54. blood glucose amount male 0 days 8 350.0 mg/dl 18.0 50.91 machine read blood glucose test strip 0.0 unx 28 days 99941 2378
SHRSP.WKY-(D3Mgh16-rs65433898)/Gcrc timed urine volume vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine output male 126 days 7 30.68 ml/d 11.32 29.95 metabolic cage urine volume measurement method 0.0 0 102134 2646
WKY/Gcrc urine potassium level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine potassium amount male 126 days 18 71.25 mmol/l 33.04 140.18 urine potassium analysis 0.0 0 102142 2646
SHRSP/Gcrc urine creatinine level vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days) Koh-Tan HH, et al., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155. urine creatinine amount male 126 days 17 6.85 mg/dl 2.77 11.4 urine creatinine analysis 0.0 0 102151 2646
WKY/NHsd urine sodium excretion rate standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. urine sodium amount male 0 days 7 1.0 mEq/d 0.2 0.53 urine sodium analysis 0.0 0 mmol/d 99183 2238
WKY/NHsd urine sodium excretion rate controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. urine sodium amount male 0 days 7 41.9 mEq/d 5.2 13.76 urine sodium analysis 0.0 0 99185 2238
WKY/NHsd mean arterial blood pressure controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days) Lankhorst S, et al., Hypertension. 2017 May;69(5):919-926. doi: 10.1161/HYPERTENSIONAHA.116.08565. Epub 2017 Mar 20. arterial blood pressure trait male 0 days 7 116.0 mmHg 1.0 2.65 intra-aortic radiotelemetry 0.0 0 99189 2238
SD-Nfe2l2em1Mcwi-/- mean arterial blood pressure controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. arterial blood pressure trait male 9 days-11 days 3 102.0 mmHg 3.0 5.2 vascular fluid filled catheter 0.0 0 100740 2520
SD-Nfe2l2em1Mcwi+/+ body weight controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) Priestley JR, et al., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4. body mass male 9 days-11 days 8 281.0 g 17.7 50.06 body weighing method 0.0 0 100733 2520
SS/JrHsdMcwi heart left ventricle weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left ventricle mass male 56 days 7 0.64 g 0.02 0.05 post excision weight measurement 0.0 0 106538 3032
SS-Sod3m1Mcwi tibia length vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. tibia length male 56 days 10 3.64 cm 0.03 0.09 post excision length measurement 0.0 0 106555 3032
SS-Sod3m1Mcwi right atrium weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56 days 10 0.01 g 0.0 0.0 post excision weight measurement 0.0 0 106563 3032
SS-Sod3m1Mcwi liver weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56 days 10 10.6 g 0.22 0.7 post excision weight measurement 0.0 0 106575 3032
SS.ZUC-Leprfa-/-/Slc serum triglyceride level vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood triglyceride amount male 91 days 6 2196.13 mg/dl 204.52 500.97 serum triglyceride analysis 0.0 0 101950 2644
SS.ZUC-Leprfa-/-/Slc serum free fatty acids level vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood free fatty acid amount male 91 days 6 1.42 mmol/l 0.14 0.34 serum free fatty acid analysis 0.0 0 101953 2644
SS.ZUC-Leprfa-/-/Slc serum insulin level vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. blood insulin amount male 91 days 6 0.0 mg/dl 0.0 0.0 serum insulin analysis 0.0 0 101959 2644
SS.ZUC-Leprfa-/-/Slc heart posterior wall thickness vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. heart left ventricle posterior wall thickness male 91 days 13 0.21 cm 0.01 0.02 echocardiography 0.0 0 101998 2644
SS.ZUC-Leprfa-/-/Slc ejection fraction vehicle control condition (0.5 %) (for 28 days) Yamada Y, et al., Int J Cardiol. 2017 Aug 1;240:332-338. doi: 10.1016/j.ijcard.2017.04.103. Epub 2017 May 4. cardiac output trait male 91 days 13 82.5 % 1.94 6.99 echocardiography 0.0 0 102010 2644
SS-Sod3m1Mcwi heart right ventricle weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56 days 10 0.61 mg/g 0.01 0.03 post excision weight measurement 0.0 0 106583 3032
SS/JrHsdMcwi heart left ventricle weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left ventricle mass male 56 days 7 2.43 mg/g 0.05 0.13 post excision weight measurement 0.0 0 106586 3032
SD retinal uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. retina blood vessel morphology trait male 35 days-49 days 3 24.0 % 5.8 10.05 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106117 3028
SD aqueous humor uptake index of quinidine tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. aqueous humor morphology trait male 35 days-49 days 3 5.95 % 0.38 0.66 liquid scintillation counting 0.0 carotid injection 15 sec post excision quinidine uptake index 106132 3028
SD-Abcb1aem1Sage-/- aqueous humor uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. aqueous humor morphology trait male 42 days-56 days 3 24.8 % 1.4 2.42 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106147 3028
SD brain uptake index of digoxin tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. blood-brain barrier morphology trait male 35 days-49 days 3 0.99 % 0.35 0.61 liquid scintillation counting 0.0 carotid injection 15 sec post excision digoxin uptake index 106153 3028
SD brain uptake index of verapamil tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. blood-brain barrier morphology trait male 35 days-49 days 3 9.07 % 0.89 1.54 liquid scintillation counting 0.0 carotid injection 15 sec post excision verapamil uptake index 106156 3028
SD-Ahrem2Sage spleen weight to body weight ratio vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. spleen mass female 84 days 10 0.29 % 0.02 0.07 post excision weight measurement 0 105897 3021
SS/JrHsdMcwi heart right atrium weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56 days 7 0.44 mg/mm 0.04 0.1 post excision weight measurement 0.0 0 106622 3032
SS-Sod3m1Mcwi heart right atrium weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56 days 10 0.41 mg/mm 0.03 0.09 post excision weight measurement 0.0 0 106623 3032
Crl:CD(SD) retinal outer layer thickness vehicle control condition (0 mg/kg) (for 13 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 67 days-74 days 5 138.5 um 3.4 7.6 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography outer retinal layer 105474 3016
Crl:CD(SD) retinal outer layer thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111 days-118 days 5 132.2 um 3.71 8.3 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography outer retinal layer 105490 3016
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 136 days-143 days 5 123.8 um 4.83 10.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography inner retinal layer 105502 3016
Crl:CD(SD) full retina thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 137 days-144 days 5 191.6 um 7.56 16.9 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 full retina layer 105458 3016
Crl:CD(SD) retinal inner layer thickness vehicle control condition (0 mg/kg) (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal layer morphology trait male 111 days-118 days 5 121.9 um 4.38 9.8 ex vivo light microscopy with histochemistry and digital image analysis 0.0 0 optical coherence tomography inner retinal layer 105494 3016
Crl:CD(SD) retinal outer nuclear layer photoreceptor nucleus count vehicle control condition (for 25 days) Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. retinal outer nuclear layer morphology trait male 137 days-144 days 5 10.5 null 0.4 0.9 ex vivo light microscopy with histochemistry 0.0 0 nuclei per cell 105462 3016
Hsd:SD red blood cell count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 7.47 x 10E6 cells/ul 0.21 0.66 automated hematology analysis 0 105932 3021
SD-Ahrem2Sage red blood cell count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. erythrocyte quantity female 84 days 10 7.41 x 10E6 cells/ul 0.36 1.14 automated hematology analysis 0 105933 3021
SD-Ahrem2Sage blood hemoglobin level vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. blood hemoglobin amount female 84 days 10 14.01 g/dl 0.62 1.96 automated hematology analysis 0 105945 3021
Hsd:SD platelet count vehicle control condition (5 ml/kg) (for 28 days) Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. platelet quantity female 84 days 10 1308.4 x 1000 cells/ul 220.08 695.95 automated hematology analysis 0 106004 3021
SHRSP/A3NCrl time to peak measurement of Gd-DTPA uptake by kidney cortex controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. xenobiotic metabolism trait male 161 days-175 days 6 14.3 s 1.2 17.98 Dynamic Contrast-Enhanced Magnetic Resonance Imaging cortex of kidney 400.0 0 5 seconds x 10 measurements averaged x 8 regions 5 seconds x 10 measurements averaged x 8 regions 107374 3083
SHRSP/A3NCrl body weight controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days) Lenhard SC, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. doi: 10.1124/jpet.103.057398. Epub 2003 Oct 15. body mass male 161 days-175 days 6 307.0 g 8.0 19.6 body weighing method 0.0 0 107382 3083
MWF/FubRkb timed urine volume vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. urine output male 114 days 10 10.1 ml/d 0.4 1.26 metabolic cage urine volume measurement method 0.0 0 109401 3140
Crl:WI urine albumin excretion rate vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. urine albumin amount male 114 days 10 0.17 mg/d 0.01 0.03 enzyme linked immunosorbent assay 0.0 0 109403 3140
Crl:WI pulse wave velocity vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. arterial blood pressure trait male 112 days 10 5.4 /ms 0.5 1.58 tail cuff plethysmography 0.0 0 109415 3140
MWF/FubRkb pulse wave velocity vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. arterial blood pressure trait male 112 days 10 5.6 /ms 0.5 1.58 tail cuff plethysmography 0.0 0 109417 3140
Crl:WI mesenteric artery wall thickness vehicle control condition Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. mesenteric artery morphology trait male 114 days 10 37.8 um 1.5 4.74 confocal microscopy 0.0 0 109419 3140
MWF/FubRkb mesenteric artery wall thickness vehicle control condition Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. mesenteric artery morphology trait male 114 days 10 36.3 um 1.1 3.48 confocal microscopy 0.0 0 109421 3140
MWF/FubRkb mesenteric artery media thickness vehicle control condition Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. mesenteric artery morphology trait male 114 days 10 19.6 um 0.7 2.21 confocal microscopy 0.0 0 109429 3140
MWF/FubRkb acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasodilation trait male 114 days 10 82.3 % 3.0 9.49 wire myography mesenteric artery 0.0 0 109433 3140
Crl:WI negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasoconstriction trait male 114 days 10 6.7 null 0.1 0.32 wire myography 0.0 0 109443 3140
MWF/FubRkb negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. vasoconstriction trait male 114 days 10 6.9 null 0.1 0.32 wire myography 0.0 0 109445 3140
Hsd:SD scotopic A wave amplitude of ERG waveform vehicle control condition (2 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. rod electrophysiology trait both 0 days 4 142.0 uV electroretinography cornea 0.0 subretinal injection 30 days scotopic a-wave ERG 108642 3128
RCS-p+/LavRrrc photopic B wave amplitude of ERG waveform vehicle control condition (2 ul) then visible light stimulus (25 cd x s/m2) Baranov P, et al., J Ocul Pharmacol Ther. 2017 Jun;33(5):412-422. doi: 10.1089/jop.2016.0121. Epub 2017 Apr 25. cone electrophysiology trait not specified 119 days 7 23.1 uV 1.0 2.65 electroretinography cornea 0.0 intravitrial injection 98 days 109739 3154
MWF/FubRkb body weight vehicle control condition (for 28 days) Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275. body mass male 112 days 10 362.8 g 12.8 40.48 body weighing method 0.0 0 109389 3140
SS/JrHsdMcwi diastolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56 days 6 84.0 mmHg 4.05 9.92 vascular fluid filled catheter 0.0 0 106806 3032
SS/NEisSlc systolic blood pressure vehicle control condition (for 547.5 days) Hirawa N, et al., Hypertension. 1999 Sep;34(3):496-502. arterial blood pressure trait not specified 547 days 10 137.0 mmHg 3.0 9.49 vascular indwelling catheter method femoral artery 0.0 0 106791 2339
ISIAH spleen cell count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. spleen morphology trait male 150 days-180 days 10 583.56 x10E6/organ 109.7 346.9 isolated cell counting method 0.0 IP injection 1 days saline 107703 3096
WAG/Nov CD3+ thymocyte count vehicle control condition (2 ml/kg) (for 1 days) Shurligina AV, et al., Bull Exp Biol Med. 2013 Aug;155(4):421-4. doi: 10.1007/s10517-013-2167-4. thymocyte quantity male 150 days-180 days 10 1021.26 x10E6/organ 145.57 460.33 flow cytometry method 0.0 IP injeciton 1 days saline cd3+ thymocyte 107715 3096
BDIX/CrCrl blood lymphocyte count to total leukocyte count ratio DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) Pica F, etal., Anticancer Drugs. 2012 Jan;23(1):32-42. doi: 10.1097/CAD.0b013e32834a0c8e. lymphocyte quantity male 71 days 10 8.1 % 0.25 0.8 automated differential white blood cell count test 0.0 0