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PhenoMiner Database Result        View data table  |  Download data table  |  View expanded data table        


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# of AnimalsPhenotypeStrainSexValueUnitsConditionsRecord IDCondition 1aCondition 1bCondition 1cCondition 2aCondition 2bCondition 3aCondition 3bCondition 4Condition 5aCondition 5bCondition 6
5spleen wet weightHsd:WImale0.708gvehicle control condition (for 91 days)76115vehicle control condition (for 91 days)
5serum total protein levelHsd:WImale9.38g/dlvehicle control condition (for 91 days)76125vehicle control condition (for 91 days)
5serum total cholesterol levelHsd:WImale68.12mg/dlvehicle control condition (for 91 days)76130vehicle control condition (for 91 days)
6kidney superoxide dismutase activity to total protein level ratioHsd:WImale13.53U/mgvehicle control condition (for 10 days)76187vehicle control condition (for 10 days)
6kidney superoxide dismutase activity to total protein level ratioHsd:WImale8.13U/mgvehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) 76188vehicle control condition (for 10 days)cisplatin (7.5 mg/kg)
8body weightBluHsd:LEmale353.1gvehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days)75955vehicle control condition (for 30 days)controlled in utero environment (for 9 days)maternal milk (for 21 days)
8total food calorie intake rateBluHsd:LEmale2995.2kcal/dcontrolled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76182controlled in utero environment (for 9 days)vehicle control condition (for 30 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
8food calorie intake level to change in body weight ratioBluHsd:LEmale10.1kcal/gcontrolled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days)76204controlled in utero environment (for 9 days)vehicle control condition (for 30 days)maternal milk (for 21 days)
6kidney catalase activity to total protein level ratioHsd:WImale35.98nmol/mgvehicle control condition (for 10 days)76234vehicle control condition (for 10 days)
6kidney catalase activity to total protein level ratioHsd:WImale21.73nmol/mgvehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) 76235vehicle control condition (for 10 days)cisplatin (7.5 mg/kg)
8food intake weight to change in body weight ratioBluHsd:LEmale6.7g/gcontrolled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days)76203controlled in utero environment (for 9 days)vehicle control condition (for 30 days)maternal milk (for 21 days)
6body weightHsd:WImale140.6gvehicle control condition (for 10 days)75951vehicle control condition (for 10 days)
6body weightHsd:WImale137.6gvehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) 75952vehicle control condition (for 10 days)cisplatin (7.5 mg/kg)
8body weightBluHsd:LEmale457.7gvehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days)75962vehicle control condition (for 30 days)controlled in utero environment (for 9 days)maternal milk (for 21 days)
6timed urine volumeHsd:WImale6.8ml/dvehicle control condition (for 10 days)75965vehicle control condition (for 10 days)
6timed urine volumeHsd:WImale21.8ml/dvehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) 75966vehicle control condition (for 10 days)cisplatin (7.5 mg/kg)
8body weight gainBluHsd:LEmale104.6gvehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days)75969vehicle control condition (for 30 days)controlled in utero environment (for 9 days)maternal milk (for 21 days)
6serum creatinine levelHsd:WImale0.54mg/dlvehicle control condition (for 10 days)75972vehicle control condition (for 10 days)
6serum creatinine levelHsd:WImale1.69mg/dlvehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) 75973vehicle control condition (for 10 days)cisplatin (7.5 mg/kg)
6serum urea nitrogen levelHsd:WImale69.64mg/dlvehicle control condition (for 10 days)75976vehicle control condition (for 10 days)
6serum urea nitrogen levelHsd:WImale96.11mg/dlvehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) 75977vehicle control condition (for 10 days)cisplatin (7.5 mg/kg)
5body weightHsd:WImale388gvehicle control condition (for 91 days)76041vehicle control condition (for 91 days)
5change in body weight to body weight ratioHsd:WImale255%vehicle control condition (for 91 days)76065vehicle control condition (for 91 days)
5right kidney wet weightHsd:WImale1.214gvehicle control condition (for 91 days)76070vehicle control condition (for 91 days)
5left kidney wet weightHsd:WImale1.192gvehicle control condition (for 91 days)76075vehicle control condition (for 91 days)
5right kidney wet weight to body weight ratioHsd:WImale3.138mg/gvehicle control condition (for 91 days)76080vehicle control condition (for 91 days)
5left kidney wet weight to body weight ratioHsd:WImale3.072mg/gvehicle control condition (for 91 days)76085vehicle control condition (for 91 days)
5liver wet weightHsd:WImale13.6gvehicle control condition (for 91 days)76090vehicle control condition (for 91 days)
5liver weight to body weight ratioHsd:WImale34.846g/kgvehicle control condition (for 91 days)76095vehicle control condition (for 91 days)
5spleen weight to body weight ratioHsd:WImale0.1832%vehicle control condition (for 91 days)76120vehicle control condition (for 91 days)
5serum triglyceride levelHsd:WImale156.94mg/dlvehicle control condition (for 91 days)76135vehicle control condition (for 91 days)
8body weightBluHsd:LEmale345.8gvehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days)76140vehicle control condition (for 30 days)controlled in utero environment (for 9 days)maternal milk (for 21 days)
5serum calcium levelHsd:WImale12.82mg/dlvehicle control condition (for 91 days)76141vehicle control condition (for 91 days)
8body weightBluHsd:LEmale491.1gvehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76148vehicle control condition (for 30 days)controlled in utero environment (for 9 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
5serum albumin levelHsd:WImale0.04486g/dlvehicle control condition (for 91 days)76149vehicle control condition (for 91 days)
5total serum bilirubin levelHsd:WImale0.96mg/dlvehicle control condition (for 91 days)76156vehicle control condition (for 91 days)
8body weight gainBluHsd:LEmale145.3gvehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76161vehicle control condition (for 30 days)controlled in utero environment (for 9 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
5serum urea nitrogen levelHsd:WImale77.76mg/dlvehicle control condition (for 91 days)76164vehicle control condition (for 91 days)
8total food calorie intake rateBluHsd:LEmale2103.7kcal/dvehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days)76169vehicle control condition (for 30 days)controlled in utero environment (for 9 days)maternal milk (for 21 days)
5serum creatinine levelHsd:WImale0.68mg/dlvehicle control condition (for 91 days)76170vehicle control condition (for 91 days)
5serum lactate dehydrogenase activity levelHsd:WImale1068U/lvehicle control condition (for 91 days)76177vehicle control condition (for 91 days)
6kidney glutathione peroxidase activity to total protein level ratioHsd:WImale22.63U/mgvehicle control condition (for 10 days)76191vehicle control condition (for 10 days)
6kidney glutathione peroxidase activity to total protein level ratioHsd:WImale7.54U/mgvehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) 76192vehicle control condition (for 10 days)cisplatin (7.5 mg/kg)
8food intake weight to change in body weight ratioBluHsd:LEmale4.7g/gcontrolled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76197controlled in utero environment (for 9 days)vehicle control condition (for 30 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
8food calorie intake level to change in body weight ratioBluHsd:LEmale10.4kcal/gcontrolled in utero environment (for 9 days) and vehicle control condition (for 30 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76198controlled in utero environment (for 9 days)vehicle control condition (for 30 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
8both testes wet weightBluHsd:LEmale3.4gvehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days)76233vehicle control condition (for 30 days)controlled in utero environment (for 9 days)maternal milk (for 21 days)
6kidney glutathione levelHsd:WImale12384.996ug/gvehicle control condition (for 10 days)76238vehicle control condition (for 10 days)
6kidney glutathione levelHsd:WImale7882.758ug/gvehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) 76239vehicle control condition (for 10 days)cisplatin (7.5 mg/kg)
8both testes wet weightBluHsd:LEmale3.4gvehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76249vehicle control condition (for 30 days)controlled in utero environment (for 9 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
8serum testosterone levelBluHsd:LEmale7.3ng/mlvehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days)76252vehicle control condition (for 30 days)controlled in utero environment (for 9 days)maternal milk (for 21 days)
8serum testosterone levelBluHsd:LEmale10ng/mlvehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76253vehicle control condition (for 30 days)controlled in utero environment (for 9 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
8serum estradiol levelBluHsd:LEmale370pg/mlvehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days)76254vehicle control condition (for 30 days)controlled in utero environment (for 9 days)maternal milk (for 21 days)
8serum estradiol levelBluHsd:LEmale290pg/mlvehicle control condition (for 30 days) and controlled in utero environment (for 9 days) then maternal milk (for 21 days) then controlled fat content diet (21.2 %) (for 28 days)76255vehicle control condition (for 30 days)controlled in utero environment (for 9 days)maternal milk (for 21 days)controlled fat content diet (21.2 %) (for 28 days)
6kidney lipid peroxide levelHsd:WImale0.75nmol/mgvehicle control condition (for 10 days)76256vehicle control condition (for 10 days)
6kidney lipid peroxide levelHsd:WImale1.51nmol/mgvehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) 76257vehicle control condition (for 10 days)cisplatin (7.5 mg/kg)
32serum estradiol levelCrl:CD(SD)female34.4pg/mlmaternal milk (for 20 days) and vehicle control condition (for 15 days)76260maternal milk (for 20 days)vehicle control condition (for 15 days)
32serum progesterone levelCrl:CD(SD)female12.5ng/mlmaternal milk (for 20 days) and vehicle control condition (for 15 days)76262maternal milk (for 20 days)vehicle control condition (for 15 days)
32mammary tumor numberCrl:CD(SD)female2.84maternal milk (for 20 days) and vehicle control condition (for 15 days) then 7,12-dimethyltetraphene (DMBA) (30 mg/kg) (for 1 days)76264maternal milk (for 20 days)vehicle control condition (for 15 days)7,12-dimethyltetraphene (DMBA) (30 mg/kg) (for 1 days)
32post-insult time to mammary tumor formationCrl:CD(SD)female65dmaternal milk (for 20 days) and vehicle control condition (for 15 days) then 7,12-dimethyltetraphene (DMBA) (30 mg/kg) (for 1 days)76267maternal milk (for 20 days)vehicle control condition (for 15 days)7,12-dimethyltetraphene (DMBA) (30 mg/kg) (for 1 days)
18body weight gainHanTac:WHfemale82.4gvehicle control condition (for 14 days)76270vehicle control condition (for 14 days)
6both kidneys wet weightHsd:WImale0.82gvehicle control condition (for 10 days)75956vehicle control condition (for 10 days)
6both kidneys wet weightHsd:WImale1.2gvehicle control condition (for 10 days) then cisplatin (7.5 mg/kg) 75957vehicle control condition (for 10 days)cisplatin (7.5 mg/kg)
17body weightHanTac:WHmale6.2gvehicle control condition (for 1 days)96612vehicle control condition (for 1 days)
15body weightHanTac:WHfemale29.1gvehicle control condition (between 16 and 17 days)96687vehicle control condition (between 16 and 17 days)
18number of fetuses lost perinatally to litter size ratioHanTac:WHfemale8.5%vehicle control condition (for 14 days)96592vehicle control condition (for 14 days)
18number of perinatal live-born offspring deaths to litter size ratioHanTac:WHfemale3.2%vehicle control condition (for 14 days)96602vehicle control condition (for 14 days)
17anogenital distanceHanTac:WHmale4.1mmvehicle control condition (for 1 days)96617vehicle control condition (for 1 days)
18right testis wet weightHanTac:WHmale51.3mgvehicle control condition (between 16 and 17 days)96637vehicle control condition (between 16 and 17 days)
18both epididymides wet weightHanTac:WHmale0.0228gvehicle control condition (between 16 and 17 days)96652vehicle control condition (between 16 and 17 days)
18both seminal vesicles wet weightHanTac:WHmale7.1mgvehicle control condition (between 16 and 17 days)96657vehicle control condition (between 16 and 17 days)
18combined levator ani and bulbocavernosus muscle weightHanTac:WHmale26mgvehicle control condition (between 16 and 17 days)96662vehicle control condition (between 16 and 17 days)
18liver wet weightHanTac:WHmale0.7537gvehicle control condition (between 16 and 17 days)96672vehicle control condition (between 16 and 17 days)
18both adrenal glands wet weightHanTac:WHmale7.5mgvehicle control condition (between 16 and 17 days)96677vehicle control condition (between 16 and 17 days)
15left ovary wet weightHanTac:WHfemale3.2mgvehicle control condition (between 16 and 17 days)96697vehicle control condition (between 16 and 17 days)
6absolute change in mean arterial blood pressureWKY/Izmmale27mmHgvehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) 84566vehicle control condition (2 ul) (for 0 hours)air-jet exposure (for 0 hours)angiotensin II (20 ng)
6absolute change in mean arterial blood pressureWKY.SHRSP-(D1Wox29-D1Arb21)/Izmmale32mmHgvehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) 84568vehicle control condition (2 ul) (for 0 hours)air-jet exposure (for 0 hours)angiotensin II (20 ng)
6absolute change in mean arterial blood pressureWKY/Izmmale50mmHgvehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) then phenylephrine (3 ug) 84570vehicle control condition (2 ul) (for 0 hours)air-jet exposure (for 0 hours)angiotensin II (20 ng) phenylephrine (3 ug)
6absolute change in mean arterial blood pressureWKY.SHRSP-(D1Wox29-D1Arb21)/Izmmale50mmHgvehicle control condition (2 ul) (for 0 hours) then air-jet exposure (for 0 hours) then angiotensin II (20 ng) then phenylephrine (3 ug) 84572vehicle control condition (2 ul) (for 0 hours)air-jet exposure (for 0 hours)angiotensin II (20 ng) phenylephrine (3 ug)
4serum alanine aminotransferase activity levelF344/NHsdnot specified35U/lfasting (between 12 and 15 hours) then vehicle control condition (for 1 days)84754fasting (between 12 and 15 hours)vehicle control condition (for 1 days)
6absolute change in mean arterial blood pressureWKY/Izmmale-3mmHgair-jet exposure (for 0 hours) then vehicle control condition (2 ul) (for 0 hours)84553air-jet exposure (for 0 hours)vehicle control condition (2 ul) (for 0 hours)
6absolute change in mean arterial blood pressureWKY.SHRSP-(D1Wox29-D1Arb21)/Izmmale-1mmHgair-jet exposure (for 0 hours) then vehicle control condition (2 ul) (for 0 hours)84555air-jet exposure (for 0 hours)vehicle control condition (2 ul) (for 0 hours)
6absolute change in heart rateWKY/Izmmale0beats/minair-jet exposure (for 0 hours) then vehicle control condition (2 ul) (for 0 hours)84562air-jet exposure (for 0 hours)vehicle control condition (2 ul) (for 0 hours)
6absolute change in heart rateWKY.SHRSP-(D1Wox29-D1Arb21)/Izmmale-5beats/minair-jet exposure (for 0 hours) then vehicle control condition (2 ul) (for 0 hours)84564air-jet exposure (for 0 hours)vehicle control condition (2 ul) (for 0 hours)
4serum alanine aminotransferase activity levelHsd:SDnot specified30U/lfasting (between 12 and 15 hours) then vehicle control condition (for 1 days)84757fasting (between 12 and 15 hours)vehicle control condition (for 1 days)
18gestation period lengthHanTac:WHfemale23dvehicle control condition (for 14 days)96583vehicle control condition (for 14 days)
18litter sizeHanTac:WHfemale11.8vehicle control condition (for 14 days)96597vehicle control condition (for 14 days)
18number of male offspring to litter size ratioHanTac:WHfemale50.5%vehicle control condition (for 14 days)96607vehicle control condition (for 14 days)
17anogenital distanceHanTac:WHfemale2.2mmvehicle control condition (for 1 days)96622vehicle control condition (for 1 days)
17areola mammae/nipple numberHanTac:WHmale0.1vehicle control condition (for 14 days)96627vehicle control condition (for 14 days)
18body weightHanTac:WHmale28.6gvehicle control condition (between 16 and 17 days)96632vehicle control condition (between 16 and 17 days)
18left testis wet weightHanTac:WHmale50.9mgvehicle control condition (between 16 and 17 days)96642vehicle control condition (between 16 and 17 days)
18ventral prostate gland wet weightHanTac:WHmale0.0117gvehicle control condition (between 16 and 17 days)96647vehicle control condition (between 16 and 17 days)
15right ovary wet weightHanTac:WHfemale2.9mgvehicle control condition (between 16 and 17 days)96692vehicle control condition (between 16 and 17 days)
15thyroid gland wet weightHanTac:WHfemale4.7mgvehicle control condition (between 16 and 17 days)96707vehicle control condition (between 16 and 17 days)
15retroperitoneal fat pad weightHanTac:WHfemale0.0295gvehicle control condition (between 16 and 17 days)96712vehicle control condition (between 16 and 17 days)
18number of zygotes/embryos lost postimplantation to litter size ratioHanTac:WHfemale7.9%vehicle control condition (for 14 days)96588vehicle control condition (for 14 days)
18bulbourethral gland wet weightHanTac:WHmale1.7mgvehicle control condition (between 16 and 17 days)96667vehicle control condition (between 16 and 17 days)
18retroperitoneal fat pad weightHanTac:WHmale0.038gvehicle control condition (between 16 and 17 days)96682vehicle control condition (between 16 and 17 days)
15liver wet weightHanTac:WHfemale0.7988gvehicle control condition (between 16 and 17 days)96702vehicle control condition (between 16 and 17 days)
6left ventricular end-diastolic blood pressureSDmale13mmHgartificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98826artificial aortocaval fistula (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6left ventricular end-diastolic blood pressureSDmale3mmHgsham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98827sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-systolic blood pressureSDmale56mmHgartificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98838artificial aortocaval fistula (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6left ventricular end-systolic blood pressureSDmale64mmHgsham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98839sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle weight to body weight ratioSDmale2.6mg/gartificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days)98874artificial aortocaval fistula (for 2 days)vehicle control condition (for 2 days)
6heart left ventricle weight to body weight ratioSDmale2.3mg/gsham surgical control condition (for 2 days) then vehicle control condition (for 2 days)98875sham surgical control condition (for 2 days)vehicle control condition (for 2 days)
7creatinine clearanceWKY/NHsdmale3.1ml/minstandard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99179standard rat chow (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7creatinine clearanceWKY/NHsdmale3.5ml/mincontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99181controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
6maximum rate of positive change in left ventricular blood pressureSDmale8259mmHg/sartificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98886artificial aortocaval fistula (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6maximum rate of positive change in left ventricular blood pressureSDmale8231mmHg/ssham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98887sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6maximum rate of negative change in left ventricular blood pressureSDmale-6032mmHg/sartificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98890artificial aortocaval fistula (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6maximum rate of negative change in left ventricular blood pressureSDmale-7197mmHg/ssham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98891sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart rateSDmale420beats/minartificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98801artificial aortocaval fistula (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart rateSDmale380beats/minsham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98802sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6mean arterial blood pressureSDmale72mmHgartificial aortocaval fistula (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98814artificial aortocaval fistula (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6mean arterial blood pressureSDmale86mmHgsham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98815sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
10blood glucose levelWKYmale160.56mg/dlvehicle control condition (1 null) 99101vehicle control condition (1 null)
10body weightWKYmale450.39gvehicle control condition (1 null) 99107vehicle control condition (1 null)
10single kidney wet weight as percentage of body weightWKYmale0.341%vehicle control condition (1 null) 99113vehicle control condition (1 null)
10timed urine volumeWKYmale17.1ml/dvehicle control condition (1 null) 99119vehicle control condition (1 null)
11blood glucose levelWKYmale76mg/dlunilateral nephrectomy (for 28 days) then vehicle control condition99970unilateral nephrectomy (for 28 days)vehicle control condition
17blood glucose levelWKYmale324mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99971unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
11hematocritWKYmale45.2%unilateral nephrectomy (for 28 days) then vehicle control condition99975unilateral nephrectomy (for 28 days)vehicle control condition
17hematocritWKYmale44.8%unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99976unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
11glomerular filtration rate to body weight ratioWKYmale0.517ml/min/100gunilateral nephrectomy (for 28 days) then vehicle control condition99980unilateral nephrectomy (for 28 days)vehicle control condition
17glomerular filtration rate to body weight ratioWKYmale0.496ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99981unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
11renal filtration fractionWKYmale0.23unilateral nephrectomy (for 28 days) then vehicle control condition99985unilateral nephrectomy (for 28 days)vehicle control condition
17renal filtration fractionWKYmale0.293unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99986unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
11renal plasma flow to body weight ratioWKYmale2.28ml/min/100gunilateral nephrectomy (for 28 days) then vehicle control condition99990unilateral nephrectomy (for 28 days)vehicle control condition
17renal plasma flow to body weight ratioWKYmale1.72ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99991unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
11renal vascular resistanceWKYmale6.3mmHg/ml/minunilateral nephrectomy (for 28 days) then vehicle control condition99995unilateral nephrectomy (for 28 days)vehicle control condition
17renal vascular resistanceWKYmale16.7mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99996unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
11timed urine volumeWKYmale11.664ml/dunilateral nephrectomy (for 28 days) then vehicle control condition100000unilateral nephrectomy (for 28 days)vehicle control condition
17timed urine volumeWKYmale39.456ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition100001unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
7heart left ventricular end-diastolic diameterSS-Nppbem2Mcwi-/-male7.52mmvehicle control condition99768vehicle control condition
7heart left ventricular end-diastolic diameterSS-Nppbem2Mcwi-/-male8.68mmvehicle control condition99770vehicle control condition
7heart left ventricular end-diastolic diameterSS-Nppbem2Mcwi-/-male7.99mmvehicle control condition99772vehicle control condition
7heart left ventricle end-diastolic posterior wall thicknessSS-Nppbem2Mcwi-/-male2.03mmvehicle control condition99774vehicle control condition
7heart left ventricle end-systolic posterior wall thicknessSS-Nppbem2Mcwi-/-male3.29mmvehicle control condition99792vehicle control condition
7heart left ventricle fractional shorteningSS-Nppbem2Mcwi-/-male47.3%vehicle control condition99804vehicle control condition
7diastolic blood pressureSS-Nppbem2Mcwi-/-male128mmHgvehicle control condition99822vehicle control condition
7diastolic blood pressureSS-Nppbem2Mcwi-/-male142mmHgvehicle control condition99824vehicle control condition
7diastolic blood pressureSS-Nppbem2Mcwi-/-male145mmHgvehicle control condition99826vehicle control condition
7systolic blood pressureSS-Nppbem2Mcwi-/-male172mmHgvehicle control condition99828vehicle control condition
7systolic blood pressureSS-Nppbem2Mcwi-/-male195mmHgvehicle control condition99830vehicle control condition
7systolic blood pressureSS-Nppbem2Mcwi-/-male197mmHgvehicle control condition99832vehicle control condition
7mean arterial blood pressureSS-Nppbem2Mcwi-/-male142mmHgvehicle control condition99834vehicle control condition
7mean arterial blood pressureSS-Nppbem2Mcwi-/-male158mmHgvehicle control condition99836vehicle control condition
7mean arterial blood pressureSS-Nppbem2Mcwi-/-male162mmHgvehicle control condition99838vehicle control condition
7timed urine volumeSS-Nppbem2Mcwi-/-male14.7ml/dvehicle control condition99840vehicle control condition
7timed urine volumeSS-Nppbem2Mcwi-/-male21.1ml/dvehicle control condition99842vehicle control condition
7timed urine volumeSS-Nppbem2Mcwi-/-male19.5ml/dvehicle control condition99844vehicle control condition
7body weightWKYmale268gunilateral nephrectomy (for 28 days) then vehicle control condition99935unilateral nephrectomy (for 28 days)vehicle control condition
8body weightWKYmale215gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99936unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
7blood glucose levelWKYmale74mg/dlunilateral nephrectomy (for 28 days) then vehicle control condition99940unilateral nephrectomy (for 28 days)vehicle control condition
8blood glucose levelWKYmale350mg/dlunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99941unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
7glomerular filtration rate to body weight ratioWKYmale0.494ml/min/100gunilateral nephrectomy (for 28 days) then vehicle control condition99945unilateral nephrectomy (for 28 days)vehicle control condition
8glomerular filtration rate to body weight ratioWKYmale0.792ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99946unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
7renal plasma flow to body weight ratioWKYmale2.16ml/min/100gunilateral nephrectomy (for 28 days) then vehicle control condition99950unilateral nephrectomy (for 28 days)vehicle control condition
8renal plasma flow to body weight ratioWKYmale3.09ml/min/100gunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99951unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
7renal filtration fractionWKYmale0.233unilateral nephrectomy (for 28 days) then vehicle control condition99955unilateral nephrectomy (for 28 days)vehicle control condition
8renal filtration fractionWKYmale0.26unilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99956unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
7renal vascular resistanceWKYmale10mmHg/ml/minunilateral nephrectomy (for 28 days) then vehicle control condition99960unilateral nephrectomy (for 28 days)vehicle control condition
8renal vascular resistanceWKYmale9mmHg/ml/minunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99961unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
7timed urine volumeWKYmale12.384ml/dunilateral nephrectomy (for 28 days) then vehicle control condition99965unilateral nephrectomy (for 28 days)vehicle control condition
8timed urine volumeWKYmale23.472ml/dunilateral nephrectomy (for 28 days) then streptozotocin (35 mg/kg) then vehicle control condition99966unilateral nephrectomy (for 28 days)streptozotocin (35 mg/kg) vehicle control condition
7heart left ventricle end-systolic posterior wall thicknessSS-Nppbem2Mcwi-/-male3.17mmvehicle control condition99794vehicle control condition
7heart left ventricle end-systolic posterior wall thicknessSS-Nppbem2Mcwi-/-male3.41mmvehicle control condition99796vehicle control condition
7ejection fractionSS-Nppbem2Mcwi-/-male83.3%vehicle control condition99798vehicle control condition
7ejection fractionSS-Nppbem2Mcwi-/-male80.2%vehicle control condition99800vehicle control condition
7ejection fractionSS-Nppbem2Mcwi-/-male77.4%vehicle control condition99802vehicle control condition
7skin chloride level to skin dry weight ratioWKY/NHsdmale0.051mmol/gstandard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99135standard rat chow (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7skin chloride level to skin dry weight ratioWKY/NHsdmale0.068mmol/gcontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99137controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7skin water level to skin dry weight ratioWKY/NHsdmale1.432ml/gcontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99141controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7skin potassium level plus skin sodium level to skin water level ratioWKY/NHsdmale0.17standard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99143standard rat chow (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7skin potassium level plus skin sodium level to skin water level ratioWKY/NHsdmale0.176controlled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99145controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7skin chloride level to skin water level ratioWKY/NHsdmale90mmol/lstandard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99147standard rat chow (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7skin chloride level to skin water level ratioWKY/NHsdmale101mmol/lcontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99149controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7skin chloride level to skin water level ratioWKY/NHsdmale42mmol/lstandard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99151standard rat chow (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7skin chloride level to skin water level ratioWKY/NHsdmale48mmol/lcontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99153controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7skin potassium level to skin water level ratioWKY/NHsdmale80mmol/lstandard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99155standard rat chow (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7skin potassium level to skin water level ratioWKY/NHsdmale71mmol/lcontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99157controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7plasma sodium levelWKY/NHsdmale143.7mmol/lstandard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99159standard rat chow (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7plasma sodium levelWKY/NHsdmale141.4mmol/lcontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99161controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7plasma potassium levelWKY/NHsdmale3.9mmol/lstandard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99163standard rat chow (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7plasma potassium levelWKY/NHsdmale4.2mmol/lcontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99165controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7plasma chloride levelWKY/NHsdmale98.2mmol/lstandard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99167standard rat chow (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7plasma creatinine levelWKY/NHsdmale0.30882306mg/dlstandard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99171standard rat chow (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7plasma creatinine levelWKY/NHsdmale0.30090452mg/dlcontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99173controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7plasma cystatin C levelWKY/NHsdmale4mg/lstandard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99175standard rat chow (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7plasma cystatin C levelWKY/NHsdmale3.5mg/lcontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99177controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7heart left ventricle fractional shorteningSS-Nppbem2Mcwi-/-male44.3%vehicle control condition99806vehicle control condition
7heart left ventricle fractional shorteningSS-Nppbem2Mcwi-/-male41.6%vehicle control condition99808vehicle control condition
7heart left ventricle weightSS-Nppbem2Mcwi-/-male1.53gvehicle control condition99810vehicle control condition
7heart left ventricle weightSS-Nppbem2Mcwi-/-male1.67gvehicle control condition99812vehicle control condition
7heart left ventricle weightSS-Nppbem2Mcwi-/-male1.78gvehicle control condition99814vehicle control condition
7heart rateSS-Nppbem2Mcwi-/-male382beats/minvehicle control condition99816vehicle control condition
7heart rateSS-Nppbem2Mcwi-/-male349beats/minvehicle control condition99818vehicle control condition
7heart rateSS-Nppbem2Mcwi-/-male327beats/minvehicle control condition99820vehicle control condition
7skin sodium level to skin dry weight ratioWKY/NHsdmale0.11REQUEST NEW VALUEstandard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99131standard rat chow (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7skin sodium level to skin dry weight ratioWKY/NHsdmale0.144REQUEST NEW VALUEcontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99133controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7plasma chloride levelWKY/NHsdmale104.8mmol/lcontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99169controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7urine sodium excretion rateWKY/NHsdmale1mEq/dstandard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99183standard rat chow (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7urine sodium excretion rateWKY/NHsdmale41.9mEq/dcontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99185controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7mean arterial blood pressureWKY/NHsdmale101mmHgstandard rat chow (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99187standard rat chow (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
7mean arterial blood pressureWKY/NHsdmale116mmHgcontrolled sodium content diet (8 %) (for 8 days) then 0.9% sodium chloride solution (0.9 %) (for 8 days) then vehicle control condition (0.5 ml) (for 8 days)99189controlled sodium content diet (8 %) (for 8 days)0.9% sodium chloride solution (0.9 %) (for 8 days)vehicle control condition (0.5 ml) (for 8 days)
6right ventricular end-systolic blood pressureSS/JrHsdMcwimale26mmHgvehicle control condition106796vehicle control condition
15right ventricular end-systolic blood pressureSS-Sod3m1Mcwimale25.1mmHgvehicle control condition106797vehicle control condition
7body weightSS-Nppbem2Mcwi-/-male425gvehicle control condition99758vehicle control condition
7body weightSS-Nppbem2Mcwi-/-male452gvehicle control condition99760vehicle control condition
7heart intraventricular end-diastolic wall thicknessSS-Nppbem2Mcwi-/-male2.01mmvehicle control condition99762vehicle control condition
7heart intraventricular end-diastolic wall thicknessSS-Nppbem2Mcwi-/-male1.92mmvehicle control condition99764vehicle control condition
7heart intraventricular end-diastolic wall thicknessSS-Nppbem2Mcwi-/-male2.26mmvehicle control condition99766vehicle control condition
7heart left ventricle end-diastolic posterior wall thicknessSS-Nppbem2Mcwi-/-male1.89mmvehicle control condition99776vehicle control condition
7heart left ventricle end-diastolic posterior wall thicknessSS-Nppbem2Mcwi-/-male2.17mmvehicle control condition99778vehicle control condition
7heart intraventricular end-systolic wall thicknessSS-Nppbem2Mcwi-/-male3.19mmvehicle control condition99780vehicle control condition
7heart intraventricular end-systolic wall thicknessSS-Nppbem2Mcwi-/-male3.24mmvehicle control condition99782vehicle control condition
7heart intraventricular end-systolic wall thicknessSS-Nppbem2Mcwi-/-male3.48mmvehicle control condition99784vehicle control condition
7heart left ventricle end-systolic diameterSS-Nppbem2Mcwi-/-male3.98mmvehicle control condition99786vehicle control condition
7heart left ventricle end-systolic diameterSS-Nppbem2Mcwi-/-male4.83mmvehicle control condition99788vehicle control condition
7heart left ventricle end-systolic diameterSS-Nppbem2Mcwi-/-male4.67mmvehicle control condition99790vehicle control condition
7body weightMWmale220gunilateral nephrectomy (for 14 days) then vehicle control condition101142unilateral nephrectomy (for 14 days)vehicle control condition
7body weightMWmale260gunilateral nephrectomy (for 14 days) then vehicle control condition101146unilateral nephrectomy (for 14 days)vehicle control condition
7body weightMWmale286gunilateral nephrectomy (for 70 days) then vehicle control condition101154unilateral nephrectomy (for 70 days)vehicle control condition
7systolic blood pressureMWmale118mmHgunilateral nephrectomy (for 14 days) then vehicle control condition101159unilateral nephrectomy (for 14 days)vehicle control condition
7systolic blood pressureMWmale118mmHgunilateral nephrectomy (for 14 days) then vehicle control condition101163unilateral nephrectomy (for 14 days)vehicle control condition
7systolic blood pressureMWmale122mmHgunilateral nephrectomy (for 70 days) then vehicle control condition101168unilateral nephrectomy (for 70 days)vehicle control condition
7mean arterial blood pressureMWmale108mmHgunilateral nephrectomy (for 70 days) then vehicle control condition101173unilateral nephrectomy (for 70 days)vehicle control condition
7blood urea nitrogen levelMWmale25mg/dlunilateral nephrectomy (for 14 days) then vehicle control condition101178unilateral nephrectomy (for 14 days)vehicle control condition
7blood urea nitrogen levelMWmale25mg/dlunilateral nephrectomy (for 14 days) then vehicle control condition101182unilateral nephrectomy (for 14 days)vehicle control condition
7blood urea nitrogen levelMWmale26mg/dlunilateral nephrectomy (for 70 days) then vehicle control condition101187unilateral nephrectomy (for 70 days)vehicle control condition
7urine protein excretion rateMWmale11mg/dunilateral nephrectomy (for 14 days) then vehicle control condition101192unilateral nephrectomy (for 14 days)vehicle control condition
7urine protein excretion rateMWmale23mg/dunilateral nephrectomy (for 14 days) then vehicle control condition101196unilateral nephrectomy (for 14 days)vehicle control condition
7urine protein excretion rateMWmale18mg/dunilateral nephrectomy (for 70 days) then vehicle control condition101200unilateral nephrectomy (for 70 days)vehicle control condition
18urine protein excretion rateMWmale8mg/dvehicle control condition101203vehicle control condition
7blood glomerular filtration rateMWmale1.46ml/minunilateral nephrectomy (for 70 days) then vehicle control condition101205unilateral nephrectomy (for 70 days)vehicle control condition
5blood sodium levelSHR/NCrlCrljmale140mmol/lunilateral nephrectomy (for 42 days) then vehicle control condition (for 28 days)101238unilateral nephrectomy (for 42 days)vehicle control condition (for 28 days)
5blood potassium levelSHR/NCrlCrljmale5.7mmol/lunilateral nephrectomy (for 42 days) then vehicle control condition (for 28 days)101242unilateral nephrectomy (for 42 days)vehicle control condition (for 28 days)
5serum creatinine levelSHR/NCrlCrljmale0.95mg/dlunilateral nephrectomy (for 42 days) then vehicle control condition (for 28 days)101246unilateral nephrectomy (for 42 days)vehicle control condition (for 28 days)
5blood urea nitrogen levelSHR/NCrlCrljmale72mg/dlunilateral nephrectomy (for 42 days) then vehicle control condition (for 28 days)101250unilateral nephrectomy (for 42 days)vehicle control condition (for 28 days)
15creatinine clearance to body weight ratioSHR/NCrlCrljmale0.3556ml/min/100gunilateral nephrectomy (for 14 days) then vehicle control condition101254unilateral nephrectomy (for 14 days)vehicle control condition
5creatinine clearance to body weight ratioSHR/NCrlCrljmale0.14ml/min/100gunilateral nephrectomy (for 42 days) then vehicle control condition (for 28 days)101258unilateral nephrectomy (for 42 days)vehicle control condition (for 28 days)
5plasma renin activity levelSHR/NCrlCrljmale1.3ng/ml/hunilateral nephrectomy (for 42 days) then vehicle control condition (for 28 days)101262unilateral nephrectomy (for 42 days)vehicle control condition (for 28 days)
5plasma aldosterone levelSHR/NCrlCrljmale389pg/mlunilateral nephrectomy (for 42 days) then vehicle control condition (for 28 days)101266unilateral nephrectomy (for 42 days)vehicle control condition (for 28 days)
5plasma angiotensin I levelSHR/NCrlCrljmale169pg/mlunilateral nephrectomy (for 42 days) then vehicle control condition (for 28 days)101270unilateral nephrectomy (for 42 days)vehicle control condition (for 28 days)
5plasma angiotensin II levelSHR/NCrlCrljmale11.6pg/mlunilateral nephrectomy (for 42 days) then vehicle control condition (for 28 days)101274unilateral nephrectomy (for 42 days)vehicle control condition (for 28 days)
6mean arterial blood pressureCrlj:WImale138mmHgair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours)103015air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)
7mean arterial blood pressureCrlj:WImale128mmHgair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours)103016air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)
5mean arterial blood pressureGKmale137mmHgair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours)103017air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)
7mean arterial blood pressureGKmale147mmHgair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours)103018air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)
6mean arterial blood pressureCrlj:WImale90mmHgair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours)103019air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)
7mean arterial blood pressureCrlj:WImale96mmHgair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours)103020air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)
5mean arterial blood pressureGKmale108mmHgair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours)103021air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)
7mean arterial blood pressureGKmale111mmHgair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours)103022air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)
6mean arterial blood pressureCrlj:WImale99mmHgair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)103023air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)
7mean arterial blood pressureCrlj:WImale109mmHgair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)103024air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)
7mean arterial blood pressureGKmale123mmHgair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)103026air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)
6mean arterial blood pressureCrlj:WImale155mmHgair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) then meclofenamate (3 mg/kg) (for 0.5 hours)103027air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours)meclofenamate (3 mg/kg) (for 0.5 hours)
7mean arterial blood pressureCrlj:WImale136mmHgair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours)103028air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours)meclofenamate (3 mg/kg) (for 0.5 hours)
5mean arterial blood pressureGKmale151mmHgair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours)103029air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours)meclofenamate (3 mg/kg) (for 0.5 hours)
7mean arterial blood pressureGKmale140mmHgair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours)103030air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours)meclofenamate (3 mg/kg) (for 0.5 hours)
6mean arterial blood pressureCrlj:WImale120mmHgair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours)103031air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours)meclofenamate (3 mg/kg) (for 0.5 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)
7mean arterial blood pressureCrlj:WImale102mmHgair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours)103032air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours)meclofenamate (3 mg/kg) (for 0.5 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)
5mean arterial blood pressureGKmale137mmHgair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours)103033air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours)meclofenamate (3 mg/kg) (for 0.5 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)
7mean arterial blood pressureGKmale143mmHgair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours)103034air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours)meclofenamate (3 mg/kg) (for 0.5 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)
6heart rateCrlj:WImale372beats/minair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours)103035air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)
7heart rateCrlj:WImale415beats/minair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours)103036air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)
5heart rateGKmale395beats/minair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours)103037air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)
7heart rateGKmale147beats/minair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours)103038air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)
6heart rateCrlj:WImale90beats/minair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours)103039air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)
7heart rateCrlj:WImale380beats/minair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours)103040air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)
5heart rateGKmale366beats/minair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours)103041air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)
7heart rateCrlj:WImale379beats/minair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)103042air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)
6heart rateCrlj:WImale351beats/minair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)103043air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)
7heart rateCrlj:WImale384beats/minair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)103044air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)
5heart rateGKmale366beats/minair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)103045air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)
7heart rateGKmale390beats/minair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)103046air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)
6heart rateCrlj:WImale288beats/minair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) then meclofenamate (3 mg/kg) (for 0.5 hours)103047air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours)meclofenamate (3 mg/kg) (for 0.5 hours)
7heart rateCrlj:WImale287beats/minair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours)103048air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours)meclofenamate (3 mg/kg) (for 0.5 hours)
5heart rateGKmale301beats/minair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours)103049air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours)meclofenamate (3 mg/kg) (for 0.5 hours)
7heart rateGKmale344beats/minair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours)103050air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours)meclofenamate (3 mg/kg) (for 0.5 hours)
6heart rateCrlj:WImale275beats/minair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours)103051air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours)meclofenamate (3 mg/kg) (for 0.5 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)
7heart rateCrlj:WImale264beats/minair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours)103052air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours)meclofenamate (3 mg/kg) (for 0.5 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)
5heart rateGKmale252beats/minair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours)103053air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours)meclofenamate (3 mg/kg) (for 0.5 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)
7heart rateGKmale279beats/minair oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours)103054air oxygen content (5 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours)meclofenamate (3 mg/kg) (for 0.5 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)
6heart rateGKmale323beats/minvehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours)103568vehicle control condition (for 28 days)dark phase of controlled light/dark cycle (for 12 hours)
6number of spontaneous locomotor movements per unit timeWKY/NCrlmale0.9/minvehicle control condition (between 1 and 28 days) and light phase of controlled light/dark cycle (for 12 hours)103574vehicle control condition (between 1 and 28 days)light phase of controlled light/dark cycle (for 12 hours)
6number of spontaneous locomotor movements per unit timeGKmale0.9/minvehicle control condition (between 1 and 28 days) and light phase of controlled light/dark cycle (for 12 hours)103576vehicle control condition (between 1 and 28 days)light phase of controlled light/dark cycle (for 12 hours)
6number of spontaneous locomotor movements per unit timeWKY/NCrlmale2.8/minvehicle control condition (between 1 and 28 days) and dark phase of controlled light/dark cycle103582vehicle control condition (between 1 and 28 days)dark phase of controlled light/dark cycle
6number of spontaneous locomotor movements per unit timeGKmale2.9/minvehicle control condition (between 1 and 28 days) and dark phase of controlled light/dark cycle103584vehicle control condition (between 1 and 28 days)dark phase of controlled light/dark cycle
7logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)WKY/NCrlmale-7.07vehicle control condition (for 28 days)103586vehicle control condition (for 28 days)
8logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)GKmale-7.29vehicle control condition (for 28 days)103588vehicle control condition (for 28 days)
7acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselWKY/NCrlmale89.88%vehicle control condition (for 28 days)103590vehicle control condition (for 28 days)
8acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselGKmale67.1%vehicle control condition (for 28 days)103592vehicle control condition (for 28 days)
7logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)WKY/NCrlmale-8.058vehicle control condition (for 28 days)103594vehicle control condition (for 28 days)
5systolic blood pressureMWmale123mmHgvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101347vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
7systolic blood pressureMWmale116mmHgvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101350vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
5systolic blood pressureMWmale130mmHgvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101351vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
7systolic blood pressureMWmale130mmHgvehicle control condition (0 mg/kg/d) (for 10 days) then artificial aortocaval fistula (for 9 days)101353vehicle control condition (0 mg/kg/d) (for 10 days)artificial aortocaval fistula (for 9 days)
5systolic blood pressureMWmale125mmHgvehicle control condition (0 mg/kg/d) (for 3 days) then artificial aortocaval fistula (for 2 days)101356vehicle control condition (0 mg/kg/d) (for 3 days)artificial aortocaval fistula (for 2 days)
6systolic blood pressureMWmale150mmHgvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101357vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
6systolic blood pressureMWmale122mmHgvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101360vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
5systolic blood pressureMWmale160mmHgvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101361vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6systolic blood pressureMWmale123mmHgvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101364vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
5systolic blood pressureMWmale165mmHgvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101365vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
6heart rateMWmale460beats/minvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101368vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
5heart rateMWmale406beats/minvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101369vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
7heart rateMWmale450beats/minvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101372vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
5heart rateMWmale358beats/minvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101373vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
8heart left ventricle weightMWmale0.243gvehicle control condition (0 mg/kg/d) (for 3 days) then artificial aortocaval fistula (for 2 days)101400vehicle control condition (0 mg/kg/d) (for 3 days)artificial aortocaval fistula (for 2 days)
6heart left ventricle weightMWmale0.211gvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101401vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
8heart left ventricle weightMWmale0.256gvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101404vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
5heart left ventricle weightMWmale0.214gvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101405vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
8heart left ventricle weightMWmale0.285gvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101408vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
6heart left ventricle weightMWmale0.196gvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101409vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
8logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)GKmale-7.96vehicle control condition (for 28 days)103596vehicle control condition (for 28 days)
7sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselWKY/NCrlmale97.56%vehicle control condition (for 28 days)103598vehicle control condition (for 28 days)
8sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselGKmale94.07%vehicle control condition (for 28 days)103600vehicle control condition (for 28 days)
7logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)WKY/NCrlmale-7.6vehicle control condition (for 28 days)103602vehicle control condition (for 28 days)
8logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)GKmale-7.39vehicle control condition (for 28 days)103604vehicle control condition (for 28 days)
7acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselWKY/NCrlmale99.75%vehicle control condition (for 28 days)103606vehicle control condition (for 28 days)
8acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselGKmale96.96%vehicle control condition (for 28 days)103608vehicle control condition (for 28 days)
7logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)WKY/NCrlmale-8.15vehicle control condition (for 28 days)103610vehicle control condition (for 28 days)
8logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)GKmale-8.74vehicle control condition (for 28 days)103612vehicle control condition (for 28 days)
7sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselWKY/NCrlmale96.54%vehicle control condition (for 28 days)103614vehicle control condition (for 28 days)
8sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vesselGKmale86.87%vehicle control condition (for 28 days)103616vehicle control condition (for 28 days)
7aorta wall phosphorylated eNOS level to total eNOS level ratioWKY/NCrlmale1.45vehicle control condition (for 35 days)103618vehicle control condition (for 35 days)
8aorta wall phosphorylated eNOS level to total eNOS level ratioGKmale1.61vehicle control condition (for 35 days)103620vehicle control condition (for 35 days)
7mesenteric artery phosphorylated eNOS level to total eNOS level ratioWKY/NCrlmale0.94vehicle control condition (for 35 days)103622vehicle control condition (for 35 days)
8mesenteric artery phosphorylated eNOS level to total eNOS level ratioGKmale0.9vehicle control condition (for 35 days)103624vehicle control condition (for 35 days)
6heart rateMWmale448beats/minvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101387vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
5heart rateMWmale382beats/minvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101388vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
7heart insulin-like growth factor 1 receptor mRNA levelMWmale0.26pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101434vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
5heart insulin-like growth factor 1 receptor mRNA levelMWmale0.26pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101435vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
7heart insulin-like growth factor 1 mRNA levelMWmale0.53pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101456vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
13blood glucose levelLL/Mavmale65mg/dlvehicle control condition then fasting (for 16 hours)102656vehicle control conditionfasting (for 16 hours)
8blood glucose levelLH/Mavmale67mg/dlvehicle control condition then fasting (for 16 hours)102657vehicle control conditionfasting (for 16 hours)
13blood glucose levelLL/Mavmale132mg/dlvehicle control condition then fasting (for 16 hours) then glucose (2 g/kg) (for 1 hours)102659vehicle control conditionfasting (for 16 hours)glucose (2 g/kg) (for 1 hours)
8blood glucose levelLH/Mavmale121mg/dlvehicle control condition then fasting (for 16 hours) then glucose (2 g/kg) (for 1 hours)102660vehicle control conditionfasting (for 16 hours)glucose (2 g/kg) (for 1 hours)
13plasma total cholesterol levelLL/Mavmale50.5791mg/dlvehicle control condition102662vehicle control condition
8plasma total cholesterol levelLH/Mavmale66.4092mg/dlvehicle control condition102663vehicle control condition
13plasma triglyceride levelLL/Mavmale1.58mmol/lvehicle control condition102668vehicle control condition
8plasma triglyceride levelLH/Mavmale1.57mmol/lvehicle control condition102669vehicle control condition
13plasma creatinine levelLL/Mavmale0.518mg/dlvehicle control condition102674vehicle control condition
8plasma creatinine levelLH/MavRrrcmale0.53mg/dlvehicle control condition102675vehicle control condition
13heart left ventricle weight to body weight ratioLL/Mavmale20.4mg/gvehicle control condition102680vehicle control condition
8heart left ventricle weight to body weight ratioLH/MavRrrcmale23mg/gvehicle control condition102681vehicle control condition
13aorta weight to body weight ratioLL/Mavmale11.6mg/100gvehicle control condition102686vehicle control condition
8aorta weight to body weight ratioLH/MavRrrcmale12.2mg/100gvehicle control condition102687vehicle control condition
13both kidneys wet weight to body weight ratioLL/Mavmale6.53g/kgvehicle control condition102692vehicle control condition
8both kidneys wet weight to body weight ratioLH/MavRrrcmale6.36g/kgvehicle control condition102693vehicle control condition
4mean arterial blood pressureSD-Nfe2l2em1Mcwi+/+male95mmHgcontrolled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days)100739controlled sodium content diet (0.4 %) (between 70 and 84 days)controlled sodium content diet (4 %) (for 6 days)vehicle control condition (for 3 days)
3mean arterial blood pressureSD-Nfe2l2em1Mcwi-/-male102mmHgcontrolled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days)100740controlled sodium content diet (0.4 %) (between 70 and 84 days)controlled sodium content diet (4 %) (for 6 days)vehicle control condition (for 3 days)
5middle cerebral artery inner diameterSD-Nfe2l2em1Mcwi+/+male246umcontrolled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) 100745controlled sodium content diet (0.4 %) (between 70 and 84 days)controlled sodium content diet (4 %) (for 6 days)vehicle control condition (for 3 days)controlled calcium ion content physiological salt solution perfusate (0 %)
4middle cerebral artery inner diameterSD-Nfe2l2em1Mcwi-/-male248umcontrolled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) 100746controlled sodium content diet (0.4 %) (between 70 and 84 days)controlled sodium content diet (4 %) (for 6 days)vehicle control condition (for 3 days)controlled calcium ion content physiological salt solution perfusate (0 %)
5middle cerebral artery inner diameterSD-Nfe2l2em1Mcwi+/+male145umcontrolled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) then physiological salt solution perfusate100751controlled sodium content diet (0.4 %) (between 70 and 84 days)controlled sodium content diet (4 %) (for 6 days)vehicle control condition (for 3 days)physiological salt solution perfusate
4middle cerebral artery inner diameterSD-Nfe2l2em1Mcwi-/-male154umcontrolled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) then physiological salt solution perfusate100752controlled sodium content diet (0.4 %) (between 70 and 84 days)controlled sodium content diet (4 %) (for 6 days)vehicle control condition (for 3 days)physiological salt solution perfusate
5percent change in middle cerebral artery inner diameterSD-Nfe2l2em1Mcwi+/+male41.4%controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) then physiological salt solution perfusate100757controlled sodium content diet (0.4 %) (between 70 and 84 days)controlled sodium content diet (4 %) (for 6 days)vehicle control condition (for 3 days)physiological salt solution perfusate
4percent change in middle cerebral artery inner diameterSD-Nfe2l2em1Mcwi-/-male37.4%controlled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days) then physiological salt solution perfusate100758controlled sodium content diet (0.4 %) (between 70 and 84 days)controlled sodium content diet (4 %) (for 6 days)vehicle control condition (for 3 days)physiological salt solution perfusate
6serum total cholesterol levelSS.ZUC-Leprfa-/-/Slcmale333mg/dlvehicle control condition (0.5 %) (for 28 days)101941vehicle control condition (0.5 %) (for 28 days)
6serum low density lipoprotein cholesterol levelSS.ZUC-Leprfa-/-/Slcmale102.5mg/dlvehicle control condition (0.5 %) (for 28 days)101944vehicle control condition (0.5 %) (for 28 days)
6serum high density lipoprotein cholesterol levelSS.ZUC-Leprfa-/-/Slcmale97.25mg/dlvehicle control condition (0.5 %) (for 28 days)101947vehicle control condition (0.5 %) (for 28 days)
6serum triglyceride levelSS.ZUC-Leprfa-/-/Slcmale2196.13mg/dlvehicle control condition (0.5 %) (for 28 days)101950vehicle control condition (0.5 %) (for 28 days)
6serum free fatty acids levelSS.ZUC-Leprfa-/-/Slcmale1.42mmol/lvehicle control condition (0.5 %) (for 28 days)101953vehicle control condition (0.5 %) (for 28 days)
6serum glucose levelSS.ZUC-Leprfa-/-/Slcmale149.4mg/dlvehicle control condition (0.5 %) (for 28 days)101956vehicle control condition (0.5 %) (for 28 days)
6serum insulin levelSS.ZUC-Leprfa-/-/Slcmale0.000807mg/dlvehicle control condition (0.5 %) (for 28 days)101959vehicle control condition (0.5 %) (for 28 days)
13body weightLL/Mavmale219gvehicle control condition102641vehicle control condition
8body weightLH/Mavmale232gvehicle control condition102642vehicle control condition
13systolic blood pressureLL/Mavmale115mmHgvehicle control condition102644vehicle control condition
8systolic blood pressureLH/Mavmale136mmHgvehicle control condition102645vehicle control condition
13timed urine volumeLL/Mavmale8.4ml/dvehicle control condition102647vehicle control condition
8timed urine volumeLH/Mavmale8.7ml/dvehicle control condition102648vehicle control condition
13urine creatinine excretion rateLL/Mavmale7.1mg/dvehicle control condition102650vehicle control condition
8urine creatinine excretion rateLH/Mavmale8mg/dvehicle control condition102651vehicle control condition
13urine protein level to urine creatinine level ratioLL/Mavmale2.7vehicle control condition102653vehicle control condition
8urine protein level to urine creatinine level ratioLH/Mavmale5.9vehicle control condition102654vehicle control condition
8body weightMWF/ZtmRrrcmale378gvehicle control condition100901vehicle control condition
7body weightMWF/ZtmRrrcmale385gvehicle control condition100903vehicle control condition
8body weightMWF/ZtmRrrcmale433gvehicle control condition100905vehicle control condition
6heart rateMWmale448beats/minvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101382vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
5heart rateMWmale366beats/minvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101383vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
13tibia straight segment lengthSS.ZUC-Leprfa-/-/Slcmale34.62mmvehicle control condition (0.5 %) (for 28 days)101971vehicle control condition (0.5 %) (for 28 days)
13heart weight to tibia length ratioSS.ZUC-Leprfa-/-/Slcmale0.4295g/cmvehicle control condition (0.5 %) (for 28 days)101974vehicle control condition (0.5 %) (for 28 days)
13heart left ventricle weight to tibia length ratioSS.ZUC-Leprfa-/-/Slcmale0.3101g/cmvehicle control condition (0.5 %) (for 28 days)101977vehicle control condition (0.5 %) (for 28 days)
13retroperitoneal fat pad weight to tibia length ratioSS.ZUC-Leprfa-/-/Slcmale429.56mg/mmvehicle control condition (0.5 %) (for 28 days)101980vehicle control condition (0.5 %) (for 28 days)
13epididymal fat pad weight to tibia length ratioSS.ZUC-Leprfa-/-/Slcmale3.5481g/cmvehicle control condition (0.5 %) (for 28 days)101983vehicle control condition (0.5 %) (for 28 days)
13mesenteric fat pad weight to tibia length ratioSS.ZUC-Leprfa-/-/Slcmale364.22mg/mmvehicle control condition (0.5 %) (for 28 days)101986vehicle control condition (0.5 %) (for 28 days)
13inguinal fat pad weight to tibia length ratioSS.ZUC-Leprfa-/-/Slcmale1501.32mg/mmvehicle control condition (0.5 %) (for 28 days)101989vehicle control condition (0.5 %) (for 28 days)
13heart ventricle septal wall thicknessSS.ZUC-Leprfa-/-/Slcmale0.206cmvehicle control condition (0.5 %) (for 28 days)101992vehicle control condition (0.5 %) (for 28 days)
13heart left ventricular end-diastolic diameterSS.ZUC-Leprfa-/-/Slcmale8.27mmvehicle control condition (0.5 %) (for 28 days)101995vehicle control condition (0.5 %) (for 28 days)
8body weightSS/NEisSlcmale361gcontrolled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days)102311controlled sodium content diet (0.3 %) (for 42 days)controlled sodium content diet (8 %) (for 77 days)vehicle control condition (for 49 days)
8systolic blood pressureSS/NEisSlcmale226mmHgcontrolled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days)102314controlled sodium content diet (0.3 %) (for 42 days)controlled sodium content diet (8 %) (for 77 days)vehicle control condition (for 49 days)
8heart left ventricle fractional shorteningSS/NEisSlcmale24.8%controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days)102317controlled sodium content diet (0.3 %) (for 42 days)controlled sodium content diet (8 %) (for 77 days)vehicle control condition (for 49 days)
6systolic blood pressureWKY/NCrlmale121mmHgvehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours)103526vehicle control condition (for 28 days)light phase of controlled light/dark cycle (for 12 hours)
6systolic blood pressureGKmale145mmHgvehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours)103528vehicle control condition (for 28 days)light phase of controlled light/dark cycle (for 12 hours)
6systolic blood pressureWKY/NCrlmale126mmHgvehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours)103534vehicle control condition (for 28 days)dark phase of controlled light/dark cycle (for 12 hours)
6systolic blood pressureGKmale145mmHgvehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours)103536vehicle control condition (for 28 days)dark phase of controlled light/dark cycle (for 12 hours)
6diastolic blood pressureWKY/NCrlmale85mmHgvehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours)103542vehicle control condition (for 28 days)light phase of controlled light/dark cycle (for 12 hours)
6diastolic blood pressureGKmale98mmHgvehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours)103544vehicle control condition (for 28 days)light phase of controlled light/dark cycle (for 12 hours)
4neuron mitochondrion area to neuron cytoplasm area ratioWImale10.4%vehicle control condition (for 180 days)103644vehicle control condition (for 180 days)
4neuron mitochondrion area to neuron cytoplasm area ratioOXYS/Novmale3.6%vehicle control condition (for 180 days)103645vehicle control condition (for 180 days)
4neuron lysosome area to neuron cytoplasm area ratioWImale8.3%vehicle control condition (for 180 days)103647vehicle control condition (for 180 days)
4neuron lysosome area to neuron cytoplasm area ratioOXYS/Novmale11.9%vehicle control condition (for 180 days)103648vehicle control condition (for 180 days)
4neuron golgi apparatus area to neuron cytoplasm area ratioWImale1.05%vehicle control condition (for 180 days)103650vehicle control condition (for 180 days)
4neuron golgi apparatus area to neuron cytoplasm area ratioOXYS/Novmale1.2%vehicle control condition (for 180 days)103651vehicle control condition (for 180 days)
4neuron rough endoplasmic reticulum area to neuron cytoplasm area ratioWImale27.4%vehicle control condition (for 180 days)103653vehicle control condition (for 180 days)
4neuron rough endoplasmic reticulum area to neuron cytoplasm area ratioOXYS/Novmale11.2%vehicle control condition (for 180 days)103654vehicle control condition (for 180 days)
4neuron vacuole area to neuron cytoplasm area ratioWImale3.97%vehicle control condition (for 180 days)103656vehicle control condition (for 180 days)
4neuron vacuole area to neuron cytoplasm area ratioOXYS/Novmale8.23%vehicle control condition (for 180 days)103657vehicle control condition (for 180 days)
N/Aheart weight to body weight ratioSHRSP/Gcrcmale4.66g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102100vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aheart weight to body weight ratioWKY/Gcrcmale3.48g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102101vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aheart weight to body weight ratioSHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrcmale4.03g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102102vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
6heart weight to body weight ratioSHRSP.WKY-(D3Wox20-D3Rat114)/Gcrcmale4.47g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102103vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aheart weight to body weight ratioSHRSP.WKY-(D3Mgh16-D3Rat80)/Gcrcmale3.88g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102104vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
7heart weight to body weight ratioSHRSP.WKY-(D3Mgh16-D3Wox3)/Gcrcmale4.07g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102105vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aheart weight to body weight ratioSHRSP.WKY-(D3Mgh16-rs65433898)/Gcrcmale4.26g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102106vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aheart weight to body weight ratioSHRSP.WKY-(D3Mgh16-rs197649383)/Gcrcmale4.72g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102107vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
17urine urea level to urine creatinine level ratioSHRSP/Gcrcmale112.69vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)103791vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
18urine urea level to urine creatinine level ratioWKY/Gcrcmale68.85vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)103792vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
9urine urea level to urine creatinine level ratioSHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrcmale87.33vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)103793vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
7urine urea level to urine creatinine level ratioSHRSP.WKY-(D3Mgh16-rs65433898)/Gcrcmale101.15vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)103794vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
6urine urea level to urine creatinine level ratioSHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrcmale76.34vehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)103795vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aheart weight to body weight ratioSHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrcmale4.67g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102108vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aheart left ventricle weight to body weight ratioSHRSP/Gcrcmale3.64mg/gvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102109vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aheart left ventricle weight to body weight ratioWKY/Gcrcmale2.52mg/gvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102110vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aheart left ventricle weight to body weight ratioSHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrcmale3.04mg/gvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102111vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
6heart left ventricle weight to body weight ratioSHRSP.WKY-(D3Wox20-D3Rat114)/Gcrcmale3.33mg/gvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102112vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aheart left ventricle weight to body weight ratioSHRSP.WKY-(D3Mgh16-D3Rat80)/Gcrcmale2.79mg/gvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102113vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
7heart left ventricle weight to body weight ratioSHRSP.WKY-(D3Mgh16-D3Wox3)/Gcrcmale3mg/gvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102114vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aheart left ventricle weight to body weight ratioSHRSP.WKY-(D3Mgh16-rs65433898)/Gcrcmale3.12mg/gvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102115vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aheart left ventricle weight to body weight ratioSHRSP.WKY-(D3Mgh16-rs197649383)/Gcrcmale3.57mg/gvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102116vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aheart left ventricle weight to body weight ratioSHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrcmale3.28mg/gvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102117vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aboth kidneys wet weight to body weight ratioSHRSP/Gcrcmale4.11g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102118vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aboth kidneys wet weight to body weight ratioWKY/Gcrcmale2.87g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102119vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aboth kidneys wet weight to body weight ratioSHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrcmale3.65g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102120vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
6both kidneys wet weight to body weight ratioSHRSP.WKY-(D3Wox20-D3Rat114)/Gcrcmale3.78g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102121vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aboth kidneys wet weight to body weight ratioSHRSP.WKY-(D3Mgh16-D3Rat80)/Gcrcmale3.77g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102122vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aboth kidneys wet weight to body weight ratioSHRSP.WKY-(D3Mgh16-rs65433898)/Gcrcmale4.16g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102123vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Ablood glycated albumin levelSlc:Wmale1.5%vehicle control condition102874vehicle control condition
N/Ablood glycated albumin levelGK/Slcmale2.3%vehicle control condition102876vehicle control condition
N/Ablood hemoglobin A1c levelSlc:Wmale5.32%vehicle control condition102878vehicle control condition
N/Ablood hemoglobin A1c levelGK/Slcmale5.21%vehicle control condition102880vehicle control condition
N/Ablood triglyceride levelSlc:Wmale119.5mg/dlvehicle control condition102886vehicle control condition
N/Ablood triglyceride levelGK/Slcmale52.3mg/dlvehicle control condition102888vehicle control condition
N/Ablood total cholesterol levelSlc:Wmale67mg/dlvehicle control condition102890vehicle control condition
N/Ablood total cholesterol levelGK/Slcmale77.8mg/dlvehicle control condition102892vehicle control condition
N/Ablood high density lipoprotein cholesterol levelSlc:Wmale4.2mg/dlvehicle control condition102894vehicle control condition
N/Ablood high density lipoprotein cholesterol levelGK/Slcmale9mg/dlvehicle control condition102896vehicle control condition
N/Ablood low density lipoprotein cholesterol levelSlc:Wmale26.8mg/dlvehicle control condition102898vehicle control condition
N/Ablood low density lipoprotein cholesterol levelGK/Slcmale24.3mg/dlvehicle control condition102900vehicle control condition
N/Ablood urea nitrogen levelSlc:Wmale19.8mg/dlvehicle control condition102902vehicle control condition
N/Ablood urea nitrogen levelGK/Slcmale15.7mg/dlvehicle control condition102904vehicle control condition
N/Ablood creatinine levelSlc:Wmale0.33mg/dlvehicle control condition102906vehicle control condition
N/Ablood creatinine levelGK/Slcmale0.26mg/dlvehicle control condition102908vehicle control condition
N/Aurine acetoacetone levelSlc:Wmale50.3umol/lvehicle control condition102914vehicle control condition
N/Aurine acetoacetone levelGK/Slcmale91.5umol/lvehicle control condition102916vehicle control condition
N/Aurine 3-hydroxybutyrate levelSlc:Wmale265.3umol/lvehicle control condition102918vehicle control condition
N/Aurine 3-hydroxybutyrate levelGK/Slcmale323.3umol/lvehicle control condition102920vehicle control condition
N/Atimed urine volumeSlc:Wmale11.2ml/dvehicle control condition102922vehicle control condition
N/Atimed urine volumeGK/Slcmale9.6ml/dvehicle control condition102924vehicle control condition
N/Aurine glucose levelSlc:Wmale31.8mg/dlvehicle control condition102926vehicle control condition
N/Aurine glucose levelGK/Slcmale588.3mg/dlvehicle control condition102928vehicle control condition
6diastolic blood pressureWKY/NCrlmale89mmHgvehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours)103550vehicle control condition (for 28 days)dark phase of controlled light/dark cycle (for 12 hours)
6diastolic blood pressureGKmale104mmHgvehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours)103552vehicle control condition (for 28 days)dark phase of controlled light/dark cycle (for 12 hours)
6heart rateWKY/NCrlmale294beats/minvehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours)103558vehicle control condition (for 28 days)light phase of controlled light/dark cycle (for 12 hours)
6heart rateGKmale279beats/minvehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours)103560vehicle control condition (for 28 days)light phase of controlled light/dark cycle (for 12 hours)
6heart rateWKY/NCrlmale344beats/minvehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours)103566vehicle control condition (for 28 days)dark phase of controlled light/dark cycle (for 12 hours)
7heart left ventricle weightMWmale0.28gvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101390vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
5heart left ventricle weightMWmale0.22gvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101391vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
7heart left ventricle weightMWmale0.297gvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101394vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
5heart left ventricle weightMWmale0.214gvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101395vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
7heart left ventricle weightMWmale0.288gvehicle control condition (0 mg/kg/d) (for 10 days) then artificial aortocaval fistula (for 9 days)101397vehicle control condition (0 mg/kg/d) (for 10 days)artificial aortocaval fistula (for 9 days)
9heart left ventricle weight to tibia length ratioSS.ZUC-Leprfa+/+/Slcfemale0.2g/cmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101695bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8heart left ventricle weight to tibia length ratioSS.ZUC-Leprfa-/-/Slcfemale0.28g/cmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101697bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9retroperitoneal fat pad weight to tibia length ratioSS.ZUC-Leprfa+/+/Slcfemale105mg/mmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101699bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8retroperitoneal fat pad weight to tibia length ratioSS.ZUC-Leprfa-/-/Slcfemale482mg/mmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101701bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9inguinal fat pad weight to tibia length ratioSS.ZUC-Leprfa+/+/Slcfemale32mg/mmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101703bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8inguinal fat pad weight to tibia length ratioSS.ZUC-Leprfa-/-/Slcfemale209mg/mmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101705bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9heart ventricle septal wall thicknessSS.ZUC-Leprfa+/+/Slcfemale0.158cmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101707bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8heart ventricle septal wall thicknessSS.ZUC-Leprfa-/-/Slcfemale0.205cmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101709bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
15right kidney wet weightWKYmale1.3533gleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100373left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
7timed urine volumeWKYmale10.6ml/dleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100376left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
6plasma creatinine levelWKYmale0.52mg/dlleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100379left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
15kidney fibrotic lesion area to total kidney area ratioWKYmale0.75%left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100385left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
15artery tunica media width to artery inner diameter ratioWKYmale1.82left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100388left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
7heart right ventricle weightMWmale0.098gvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101412vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
5heart left ventricle weightMWmale0.061gvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101413vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
7heart right ventricle weightMWmale0.095gvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101416vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
5heart right ventricle weightMWmale0.061gvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101417vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
8heart right ventricle weightMWmale0.067gvehicle control condition (0 mg/kg/d) (for 3 days) then artificial aortocaval fistula (for 2 days)101422vehicle control condition (0 mg/kg/d) (for 3 days)artificial aortocaval fistula (for 2 days)
6heart right ventricle weightMWmale0.054gvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101423vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
8heart right ventricle weightMWmale0.068gvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101426vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
5heart right ventricle weightMWmale0.048gvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101427vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
8heart right ventricle weightMWmale0.074gvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101430vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
6heart right ventricle weightMWmale0.048gvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101431vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
7heart insulin-like growth factor 1 receptor mRNA levelMWmale0.3pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101438vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
5heart insulin-like growth factor 1 receptor mRNA levelMWmale0.39pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101439vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
7heart insulin-like growth factor 1 receptor mRNA levelMWmale0.31pmol/lvehicle control condition (0 mg/kg/d) (for 10 days) then artificial aortocaval fistula (for 9 days)101441vehicle control condition (0 mg/kg/d) (for 10 days)artificial aortocaval fistula (for 9 days)
6heart insulin-like growth factor 1 receptor mRNA levelMWmale0.21pmol/lvehicle control condition (0 mg/kg/d) (for 3 days) then artificial aortocaval fistula (for 2 days)101444vehicle control condition (0 mg/kg/d) (for 3 days)artificial aortocaval fistula (for 2 days)
6heart insulin-like growth factor 1 receptor mRNA levelMWmale0.23pmol/lvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101445vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
8heart insulin-like growth factor 1 receptor mRNA levelMWmale0.41pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101448vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
5heart insulin-like growth factor 1 receptor mRNA levelMWmale0.37pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101449vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
8heart insulin-like growth factor 1 receptor mRNA levelMWmale0.24pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101452vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
6heart insulin-like growth factor 1 receptor mRNA levelMWmale0.32pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101453vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart insulin-like growth factor 1 mRNA levelMWmale0.43pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101457vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
7heart insulin-like growth factor 1 mRNA levelMWmale1.03pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101460vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
5heart insulin-like growth factor 1 mRNA levelMWmale0.59pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101461vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
7heart insulin-like growth factor 1 mRNA levelMWmale0.61pmol/lvehicle control condition (0 mg/kg/d) (for 10 days) then artificial aortocaval fistula (for 9 days)101463vehicle control condition (0 mg/kg/d) (for 10 days)artificial aortocaval fistula (for 9 days)
6heart insulin-like growth factor 1 mRNA levelMWmale0.48pmol/lvehicle control condition (0 mg/kg/d) (for 3 days) then artificial aortocaval fistula (for 2 days)101466vehicle control condition (0 mg/kg/d) (for 3 days)artificial aortocaval fistula (for 2 days)
6heart insulin-like growth factor 1 mRNA levelMWmale0.4pmol/lvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101467vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
8heart insulin-like growth factor 1 mRNA levelMWmale0.7pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101470vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
5heart insulin-like growth factor 1 mRNA levelMWmale0.58pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101471vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
8heart insulin-like growth factor 1 mRNA levelMWmale0.8pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101474vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
6heart insulin-like growth factor 1 mRNA levelMWmale0.34pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101475vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
7heart insulin-like growth factor 1 receptor mRNA levelMWmale0.64pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101478vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
5heart insulin-like growth factor 1 receptor mRNA levelMWmale0.85pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101479vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
7heart insulin-like growth factor 1 receptor mRNA levelMWmale1.07pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101482vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
5heart insulin-like growth factor 1 receptor mRNA levelMWmale1.24pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101483vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
7heart insulin-like growth factor 1 receptor mRNA levelMWmale0.83pmol/lvehicle control condition (0 mg/kg/d) (for 10 days) then artificial aortocaval fistula (for 9 days)101485vehicle control condition (0 mg/kg/d) (for 10 days)artificial aortocaval fistula (for 9 days)
6heart insulin-like growth factor 1 receptor mRNA levelMWmale1.08pmol/lvehicle control condition (0 mg/kg/d) (for 3 days) then artificial aortocaval fistula (for 2 days)101488vehicle control condition (0 mg/kg/d) (for 3 days)artificial aortocaval fistula (for 2 days)
6heart insulin-like growth factor 1 receptor mRNA levelMWmale1pmol/lvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101489vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
8heart insulin-like growth factor 1 receptor mRNA levelMWmale0.99pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101493vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
5heart insulin-like growth factor 1 receptor mRNA levelMWmale0.79pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101494vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
8heart insulin-like growth factor 1 receptor mRNA levelMWmale0.99pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101497vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
6heart insulin-like growth factor 1 receptor mRNA levelMWmale0.65pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101498vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
9body weightSS.ZUC-Leprfa+/+/Slcfemale294gbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101661bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8body weightSS.ZUC-Leprfa-/-/Slcfemale393gbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101663bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9tibia straight segment lengthSS.ZUC-Leprfa+/+/Slcfemale35.8mmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101665bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8tibia straight segment lengthSS.ZUC-Leprfa-/-/Slcfemale32.5mmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101667bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9systolic blood pressureSS.ZUC-Leprfa+/+/Slcfemale138mmHgbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101669bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8systolic blood pressureSS.ZUC-Leprfa-/-/Slcfemale221mmHgbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101671bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9heart rateSS.ZUC-Leprfa+/+/Slcfemale380beats/minbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101673bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8heart rateSS.ZUC-Leprfa-/-/Slcfemale339beats/minbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101675bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9rate-pressure productSS.ZUC-Leprfa+/+/Slcfemale52376beats/min/mmHgbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101677bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8rate-pressure productSS.ZUC-Leprfa-/-/Slcfemale73513beats/min/mmHgbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101679bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9heart weight to tibia length ratioSS.ZUC-Leprfa+/+/Slcfemale0.263g/cmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101681bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9heart left ventricle posterior wall thicknessSS.ZUC-Leprfa+/+/Slcfemale1.5mmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101711bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8heart left ventricle posterior wall thicknessSS.ZUC-Leprfa-/-/Slcfemale2.06mmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101713bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9heart left ventricular end-diastolic diameterSS.ZUC-Leprfa+/+/Slcfemale7.21mmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101715bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8heart left ventricular end-diastolic diameterSS.ZUC-Leprfa-/-/Slcfemale7.2mmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101717bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9heart left ventricle fractional shorteningSS.ZUC-Leprfa+/+/Slcfemale39.8%bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101719bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8heart left ventricle fractional shorteningSS.ZUC-Leprfa-/-/Slcfemale47.7%bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101721bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9calculated heart left ventricle weightSS.ZUC-Leprfa+/+/Slcfemale764mgbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101723bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8calculated heart left ventricle weightSS.ZUC-Leprfa-/-/Slcfemale1114mgbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101725bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9heart relative wall thicknessSS.ZUC-Leprfa+/+/Slcfemale0.44bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101727bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8heart relative wall thicknessSS.ZUC-Leprfa-/-/Slcfemale0.57bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101729bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9E wave deceleration timeSS.ZUC-Leprfa+/+/Slcfemale35.4msbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101731bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8E wave deceleration timeSS.ZUC-Leprfa-/-/Slcfemale56.9msbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101733bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9heart isovolumetric relaxation timeSS.ZUC-Leprfa+/+/Slcfemale24.8msbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101735bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8heart isovolumetric relaxation timeSS.ZUC-Leprfa-/-/Slcfemale43.1msbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101737bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9myocardial performance indexSS.ZUC-Leprfa+/+/Slcfemale0.44bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101739bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8myocardial performance indexSS.ZUC-Leprfa-/-/Slcfemale0.61bilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101741bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9left ventricular end-diastolic blood pressureSS.ZUC-Leprfa+/+/Slcfemale2.27mmHgbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101743bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8left ventricular end-diastolic blood pressureSS.ZUC-Leprfa-/-/Slcfemale4.43mmHgbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101745bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9time constant of left ventricular pressure decaySS.ZUC-Leprfa+/+/Slcfemale36.2msbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101747bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8time constant of left ventricular pressure decaySS.ZUC-Leprfa-/-/Slcfemale47.3msbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101749bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
9heart left ventricular end-diastolic blood pressure to heart left ventricular end-diastolic diameter ratioSS.ZUC-Leprfa+/+/Slcfemale0.32mmHg/mmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101751bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
8heart left ventricular end-diastolic blood pressure to heart left ventricular end-diastolic diameter ratioSS.ZUC-Leprfa-/-/Slcfemale0.63mmHg/mmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101753bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
13heart posterior wall thicknessSS.ZUC-Leprfa-/-/Slcmale0.206cmvehicle control condition (0.5 %) (for 28 days)101998vehicle control condition (0.5 %) (for 28 days)
13heart relative wall thicknessSS.ZUC-Leprfa-/-/Slcmale0.49vehicle control condition (0.5 %) (for 28 days)102004vehicle control condition (0.5 %) (for 28 days)
13heart left ventricle fractional shorteningSS.ZUC-Leprfa-/-/Slcmale47.66%vehicle control condition (0.5 %) (for 28 days)102007vehicle control condition (0.5 %) (for 28 days)
13ejection fractionSS.ZUC-Leprfa-/-/Slcmale82.5%vehicle control condition (0.5 %) (for 28 days)102010vehicle control condition (0.5 %) (for 28 days)
13E wave deceleration timeSS.ZUC-Leprfa-/-/Slcmale53.05msvehicle control condition (0.5 %) (for 28 days)102013vehicle control condition (0.5 %) (for 28 days)
13heart isovolumetric relaxation timeSS.ZUC-Leprfa-/-/Slcmale40.75msvehicle control condition (0.5 %) (for 28 days)102016vehicle control condition (0.5 %) (for 28 days)
13time constant of left ventricular pressure decaySS.ZUC-Leprfa-/-/Slcmale33.52msvehicle control condition (0.5 %) (for 28 days)102019vehicle control condition (0.5 %) (for 28 days)
13left ventricular end-diastolic blood pressureSS.ZUC-Leprfa-/-/Slcmale17.65mmHgvehicle control condition (0.5 %) (for 28 days)102022vehicle control condition (0.5 %) (for 28 days)
13heart left ventricular end-diastolic blood pressure to heart left ventricular end-diastolic diameter ratioSS.ZUC-Leprfa-/-/Slcmale2.1mmHg/mmvehicle control condition (0.5 %) (for 28 days)102025vehicle control condition (0.5 %) (for 28 days)
8heart left ventricular end-diastolic diameterSS/NEisSlcmale8.7mmcontrolled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days)102320controlled sodium content diet (0.3 %) (for 42 days)controlled sodium content diet (8 %) (for 77 days)vehicle control condition (for 49 days)
8both kidneys wet weight to body weight ratioSS/NEisSlcmale5.19g/kgcontrolled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days)102323controlled sodium content diet (0.3 %) (for 42 days)controlled sodium content diet (8 %) (for 77 days)vehicle control condition (for 49 days)
8serum creatinine levelSS/NEisSlcmale0.47mg/dlcontrolled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days)102326controlled sodium content diet (0.3 %) (for 42 days)controlled sodium content diet (8 %) (for 77 days)vehicle control condition (for 49 days)
8serum urea nitrogen levelSS/NEisSlcmale33.6mg/dlcontrolled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days)102329controlled sodium content diet (0.3 %) (for 42 days)controlled sodium content diet (8 %) (for 77 days)vehicle control condition (for 49 days)
8creatinine clearanceSS/NEisSlcmale1.9ml/mincontrolled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days)102332controlled sodium content diet (0.3 %) (for 42 days)controlled sodium content diet (8 %) (for 77 days)vehicle control condition (for 49 days)
8timed urine volumeSS/NEisSlcmale53.6ml/dcontrolled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days)102335controlled sodium content diet (0.3 %) (for 42 days)controlled sodium content diet (8 %) (for 77 days)vehicle control condition (for 49 days)
8urine protein excretion rateSS/NEisSlcmale307mg/dcontrolled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 77 days) then vehicle control condition (for 49 days)102338controlled sodium content diet (0.3 %) (for 42 days)controlled sodium content diet (8 %) (for 77 days)vehicle control condition (for 49 days)
8body weightSD-Nfe2l2em1Mcwi+/+male281gcontrolled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days)100733controlled sodium content diet (0.4 %) (between 70 and 84 days)controlled sodium content diet (4 %) (for 6 days)vehicle control condition (for 3 days)
4body weightSD-Nfe2l2em1Mcwi-/-male299gcontrolled sodium content diet (0.4 %) (between 70 and 84 days) then controlled sodium content diet (4 %) (for 6 days) then vehicle control condition (for 3 days)100734controlled sodium content diet (0.4 %) (between 70 and 84 days)controlled sodium content diet (4 %) (for 6 days)vehicle control condition (for 3 days)
7both kidneys wet weight to body weight ratioSHRSP.WKY-(D3Mgh16-D3Wox3)/Gcrcmale3.77g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102161vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
7body weightMWmale186gvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101302vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
5body weightMWmale188gvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101303vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
7body weightMWmale184gvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101306vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
5body weightMWmale180gvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101307vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
7body weightMWmale180gvehicle control condition (0 mg/kg/d) (for 10 days) then artificial aortocaval fistula (for 9 days)101309vehicle control condition (0 mg/kg/d) (for 10 days)artificial aortocaval fistula (for 9 days)
8body weightMWmale202gvehicle control condition (0 mg/kg/d) (for 3 days) then artificial aortocaval fistula (for 2 days)101312vehicle control condition (0 mg/kg/d) (for 3 days)artificial aortocaval fistula (for 2 days)
6body weightMWmale200gvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101313vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
8body weightMWmale194gvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101316vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
5body weightMWmale192gvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101317vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
8body weightMWmale193gvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101320vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
6body weightMWmale201gvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101321vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
8systolic blood pressureLH/Mavmale160mmHgvehicle control condition102848vehicle control condition
8systolic blood pressureLH/Mavmale160mmHgvehicle control condition102849vehicle control condition
8renal blood flow rate to kidney weight ratioLH/Mavmale5ml/min/gvehicle control condition then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) 102853vehicle control conditionketamine (20 mg/kg) thiobutabarbital (75 mg/kg)
8renal vascular resistance to kidney weight ratioLH/Mavmale33ml/min/g/mmHgvehicle control condition then ketamine (20 mg/kg) and thiobutabarbital (75 mg/kg) 102857vehicle control conditionketamine (20 mg/kg) thiobutabarbital (75 mg/kg)
7body weight gainMWmale-10gvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101324vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
5body weight gainMWmale18gvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101325vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
5body weight gainMWmale12gvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101328vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
5body weight gainMWmale34gvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101329vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
7body weight gainMWmale29gvehicle control condition (0 mg/kg/d) (for 10 days) then artificial aortocaval fistula (for 9 days)101331vehicle control condition (0 mg/kg/d) (for 10 days)artificial aortocaval fistula (for 9 days)
7body weight gainMWmale-14gvehicle control condition (0 mg/kg/d) (for 3 days) then artificial aortocaval fistula (for 2 days)101334vehicle control condition (0 mg/kg/d) (for 3 days)artificial aortocaval fistula (for 2 days)
6body weight gainMWmale-6gvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101335vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
7body weight gainMWmale-5gvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101338vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
5body weight gainMWmale6gvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101339vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
8heart weight to tibia length ratioSS.ZUC-Leprfa-/-/Slcfemale0.35g/cmbilateral ovariectomy (for 42 days) then vehicle control condition (for 35 days)101693bilateral ovariectomy (for 42 days)vehicle control condition (for 35 days)
N/Aboth kidneys wet weight to body weight ratioSHRSP.WKY-(D3Mgh16-rs197649383)/Gcrcmale4.25g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102124vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
N/Aboth kidneys wet weight to body weight ratioSHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrcmale4.2g/kgvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102125vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
17water drink intake rateSHRSP/Gcrcmale78.62ml/dvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102126vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
18water drink intake rateWKY/Gcrcmale53.12ml/dvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102127vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
9water drink intake rateSHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrcmale58.47ml/dvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102128vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
7water drink intake rateSHRSP.WKY-(D3Mgh16-rs65433898)/Gcrcmale57.55ml/dvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102129vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
6water drink intake rateSHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrcmale79.16ml/dvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102130vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
17timed urine volumeSHRSP/Gcrcmale55.29ml/dvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102131vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
18timed urine volumeWKY/Gcrcmale31.8ml/dvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102132vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
9timed urine volumeSHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrcmale34.03ml/dvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102133vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
7timed urine volumeSHRSP.WKY-(D3Mgh16-rs65433898)/Gcrcmale30.68ml/dvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102134vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
6timed urine volumeSHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrcmale55.86ml/dvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102135vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
17urine sodium levelSHRSP/Gcrcmale211.14mmol/lvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102136vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
18urine sodium levelWKY/Gcrcmale220.23mmol/lvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102137vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
30heart ventricle septal wall thicknessWKYmale0.1cmleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100338left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
30heart left ventricular end-diastolic diameterWKYmale10.6mmleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100341left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
30heart left ventricle end-systolic diameterWKYmale8.9mmleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100344left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
30heart posterior wall thicknessWKYmale0.18cmleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100347left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
30heart left ventricle fractional shorteningWKYmale15.8%left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100350left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
30ejection fractionWKYmale37%left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100353left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
30E/A wave ratioWKYmale1.85left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100356left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
15right kidney wet weightWKYmale1.3533gleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100359left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
7timed urine volumeWKYmale10.6ml/dleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100362left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
6plasma creatinine levelWKYmale0.52mg/dlleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100365left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
15index of glomerular damageWKYmale1.6left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100368left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
9urine sodium levelSHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrcmale268.97mmol/lvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102138vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
7urine sodium levelSHRSP.WKY-(D3Mgh16-rs65433898)/Gcrcmale260.49mmol/lvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102139vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
6urine sodium levelSHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrcmale169.89mmol/lvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102140vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
17urine potassium levelSHRSP/Gcrcmale44.48mmol/lvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102141vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
18urine potassium levelWKY/Gcrcmale71.25mmol/lvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102142vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
9urine potassium levelSHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrcmale72.41mmol/lvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102143vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
7urine potassium levelSHRSP.WKY-(D3Mgh16-rs65433898)/Gcrcmale80.72mmol/lvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102144vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
6urine potassium levelSHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrcmale28.25mmol/lvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102145vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
17urine urea levelSHRSP/Gcrcmale131.16mmol/lvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102146vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
18urine urea levelWKY/Gcrcmale235.52mmol/lvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102147vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
9urine urea levelSHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrcmale228.93mmol/lvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102148vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
7urine urea levelSHRSP.WKY-(D3Mgh16-rs65433898)/Gcrcmale316.61mmol/lvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102149vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
6urine urea levelSHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrcmale103mmol/lvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102150vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
17urine creatinine levelSHRSP/Gcrcmale6.85368mg/dlvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102151vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
18urine creatinine levelWKY/Gcrcmale13.90776mg/dlvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102152vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
9urine creatinine levelSHRSP.WKY-(D3Mgh16-D3Rat114)/Gcrcmale10.4208mg/dlvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102153vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
7urine creatinine levelSHRSP.WKY-(D3Mgh16-rs65433898)/Gcrcmale12.38472mg/dlvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102154vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
6urine creatinine levelSHRSP.WKY-(D3Mgh16-D3Mit10)/Gcrcmale5.37072mg/dlvehicle control condition (for 126 days) then sodium chloride solution (1 %) (for 21 days)102155vehicle control condition (for 126 days)sodium chloride solution (1 %) (for 21 days)
6body weightWKY/NCrlmale463gvehicle control condition (for 28 days)103490vehicle control condition (for 28 days)
6body weightGKmale380gvehicle control condition (for 28 days)103492vehicle control condition (for 28 days)
6water intake drink rate to body weight ratioWKY/NCrlmale50ml/d/kgvehicle control condition (between 1 and 35 days)103498vehicle control condition (between 1 and 35 days)
6water intake drink rate to body weight ratioGKmale99ml/d/kgvehicle control condition (between 1 and 35 days)103500vehicle control condition (between 1 and 35 days)
6serum fructosamine levelWKY/NCrlmale153umol/lvehicle control condition (for 35 days)103502vehicle control condition (for 35 days)
6serum fructosamine levelGKmale187umol/lvehicle control condition (for 35 days)103504vehicle control condition (for 35 days)
6blood glucose levelWKY/NCrlmale113mg/dlvehicle control condition (for 28 days) then fasting (for 16 hours)103510vehicle control condition (for 28 days)fasting (for 16 hours)
6blood glucose levelGKmale122mg/dlvehicle control condition (for 28 days) then fasting (for 16 hours)103512vehicle control condition (for 28 days)fasting (for 16 hours)
6blood glucose levelWKY/NCrlmale125mg/dlvehicle control condition (for 28 days) then fasting (for 16 hours) then glucose (2 g/kg) (for 2 hours)103518vehicle control condition (for 28 days)fasting (for 16 hours)glucose (2 g/kg) (for 2 hours)
6blood glucose levelGKmale278mg/dlvehicle control condition (for 28 days) then fasting (for 16 hours) then glucose (2 g/kg) (for 2 hours)103520vehicle control condition (for 28 days)fasting (for 16 hours)glucose (2 g/kg) (for 2 hours)
30heart left ventricle infarction size to total heart left ventricle size ratioWKYmale35.8%left anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100264left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
30body weightWKYmale225gleft anterior descending coronary artery occlusion then vehicle control condition100269left anterior descending coronary artery occlusionvehicle control condition
30body weightWKYmale617gleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100272left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
30heart weightWKYmale1.573gleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100278left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
30heart left ventricle weightWKYmale0.969gleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100290left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
30lung wet weightWKYmale2.134gleft anterior descending coronary artery occlusion (for 196 days) then vehicle control condition (for 182 days)100299left anterior descending coronary artery occlusion (for 196 days)vehicle control condition (for 182 days)
13body weightSDfemale283.6gcontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days)100632controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)vehicle control condition (100 ul) (for 90 days)
13serum creatinine levelSDfemale1.65mg/dlcontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days)100637controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)vehicle control condition (100 ul) (for 90 days)
13creatinine clearanceSDfemale0.3ml/mincontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days)100642controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)vehicle control condition (100 ul) (for 90 days)
13serum parathyroid hormone levelSDfemale3496pg/mlcontrolled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then vehicle control condition (100 ul) (for 90 days)100647controlled calcium content diet (0.6 %) (for 97 days)controlled content diet (0.9 %) (for 97 days)unilateral nephrectomy (for 97 days)vehicle control condition (100 ul) (for 90 days)
5blood urea nitrogen levelPCK-Pkhd1pck/CrljCrlmale20.6mg/dlnaive control condition (for 28 days) then vehicle control condition (for 84 days)100763naive control condition (for 28 days)vehicle control condition (for 84 days)
5blood urea nitrogen levelCrl:CD(SD)male19.3mg/dlnaive control condition (for 28 days) then vehicle control condition (for 84 days)100764naive control condition (for 28 days)vehicle control condition (for 84 days)
5serum creatinine levelPCK-Pkhd1pck/CrljCrlmale0.51mg/dlnaive control condition (for 28 days) then vehicle control condition (for 84 days)100765naive control condition (for 28 days)vehicle control condition (for 84 days)
5serum creatinine levelCrl:CD(SD)male0.43mg/dlnaive control condition (for 28 days) then vehicle control condition (for 84 days)100766naive control condition (for 28 days)vehicle control condition (for 84 days)
5urine total protein excretion rateCrl:CD(SD)male36.7mg/dnaive control condition (for 28 days) then vehicle control condition (for 84 days)100768naive control condition (for 28 days)vehicle control condition (for 84 days)
6urine protein level to urine creatinine level ratioPCK-Pkhd1pck/CrljCrlmale12naive control condition (for 28 days) then vehicle control condition (for 84 days)100769naive control condition (for 28 days)vehicle control condition (for 84 days)
5urine protein level to urine creatinine level ratioCrl:CD(SD)male1.98naive control condition (for 28 days) then vehicle control condition (for 84 days)100770naive control condition (for 28 days)vehicle control condition (for 84 days)
5plasma angiotensin II level to plasma angiotensin I level ratioSHR/NCrlCrljmale80unilateral nephrectomy (for 42 days) then vehicle control condition (for 28 days)101278unilateral nephrectomy (for 42 days)vehicle control condition (for 28 days)
6body weight gainMWmale8gvehicle control condition (0 mg/kg/d) (for 8 days) then artificial aortocaval fistula (for 7 days)101342vehicle control condition (0 mg/kg/d) (for 8 days)artificial aortocaval fistula (for 7 days)
5body weight gainMWmale23gvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101343vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
6systolic blood pressureMWmale103mmHgvehicle control condition (0 mg/kg/d) (for 5 days) then artificial aortocaval fistula (for 4 days)101346vehicle control condition (0 mg/kg/d) (for 5 days)artificial aortocaval fistula (for 4 days)
7heart rateMWmale460beats/minvehicle control condition (0 mg/kg/d) (for 10 days) then artificial aortocaval fistula (for 9 days)101375vehicle control condition (0 mg/kg/d) (for 10 days)artificial aortocaval fistula (for 9 days)
5heart rateMWmale470beats/minvehicle control condition (0 mg/kg/d) (for 3 days) then artificial aortocaval fistula (for 2 days)101378vehicle control condition (0 mg/kg/d) (for 3 days)artificial aortocaval fistula (for 2 days)
6heart rateMWmale377beats/minvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101379vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
7heart right ventricle weightMWmale0.093gvehicle control condition (0 mg/kg/d) (for 10 days) then artificial aortocaval fistula (for 9 days)101419vehicle control condition (0 mg/kg/d) (for 10 days)artificial aortocaval fistula (for 9 days)
5mean arterial blood pressureGKmale118mmHgair oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)103025air oxygen content (21 %) (for 28 days)vehicle control condition (0.15 ml) (for 0.1 hours)acetylcholine (5 ug/kg/min) (for 0.1 hours)sodium nitroprusside (5 ug/kg/min) (for 0.1 hours)
6heart rateSS/JrHsdMcwimale358beats/minvehicle control condition106798vehicle control condition
8heart rateSS-Sod3m1Mcwimale354beats/minvehicle control condition106799vehicle control condition
6systolic blood pressureSS/JrHsdMcwimale115mmHgvehicle control condition106802vehicle control condition
8systolic blood pressureSS-Sod3m1Mcwimale115mmHgvehicle control condition106803vehicle control condition
6diastolic blood pressureSS/JrHsdMcwimale84mmHgvehicle control condition106806vehicle control condition
8diastolic blood pressureSS-Sod3m1Mcwimale84.2mmHgvehicle control condition106807vehicle control condition
6mean aortic pressureSS/JrHsdMcwimale94.4mmHgvehicle control condition106810vehicle control condition
8mean aortic pressureSS-Sod3m1Mcwimale94.5mmHgvehicle control condition106811vehicle control condition
10plasma creatinine levelSS/NEisSlcnot specified0.59049684mg/dlvehicle control condition (for 547.5 days)107421vehicle control condition (for 547.5 days)
10urine total protein excretion rateSS/NEisSlcnot specified215.9mg/dvehicle control condition (for 547.5 days)107437vehicle control condition (for 547.5 days)
N/Aurine protein excretion rateSHRSP/A3Nmale127mg/dcontrolled sodium chloride content drinking water (1 %) (between 35 and 49 days) and controlled fat content diet (24.5 %) (between 35 and 49 days) and vehicle control condition (between 35 and 49 days)107520controlled sodium chloride content drinking water (1 %) (between 35 and 49 days)controlled fat content diet (24.5 %) (between 35 and 49 days)vehicle control condition (between 35 and 49 days)
N/Abody weightSHRSP/A3Nmale254gcontrolled sodium chloride content drinking water (1 %) (for 42 days) and controlled fat content diet (24.5 %) (for 42 days) and vehicle control condition (for 42 days)107527controlled sodium chloride content drinking water (1 %) (for 42 days)controlled fat content diet (24.5 %) (for 42 days)vehicle control condition (for 42 days)
N/Akidney weightSHRSP/A3Nmale2.65gcontrolled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days)107531controlled sodium chloride content drinking water (1 %) (between 42 and 77 days)controlled fat content diet (24.5 %) (between 42 and 77 days)vehicle control condition (between 42 and 77 days)
17kidney glomerular tuft surface areaWKYmale13.2x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition107511unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) vehicle control condition
N/Akidney tubule regeneration foci countSHRSP/A3Nmale27.3/sectioncontrolled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days)107547controlled sodium chloride content drinking water (1 %) (between 42 and 77 days)controlled fat content diet (24.5 %) (between 42 and 77 days)vehicle control condition (between 42 and 77 days)
N/Ainterstitial nephritis foci countSHRSP/A3Nmale8.5/sectioncontrolled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days)107551controlled sodium chloride content drinking water (1 %) (between 42 and 77 days)controlled fat content diet (24.5 %) (between 42 and 77 days)vehicle control condition (between 42 and 77 days)
10plasma total cholesterol levelWAG/Novmale74.4mg/dlvehicle control condition (2 ml/kg) (for 1 days)107781vehicle control condition (2 ml/kg) (for 1 days)
10plasma total cholesterol levelISIAHmale59.5mg/dlvehicle control condition (2 ml/kg) (for 1 days)107784vehicle control condition (2 ml/kg) (for 1 days)
10plasma high density lipoprotein phospholipid levelWAG/Novmale47.1mg/dlvehicle control condition (2 ml/kg) (for 1 days)107787vehicle control condition (2 ml/kg) (for 1 days)
10plasma high density lipoprotein phospholipid levelISIAHmale36.2mg/dlvehicle control condition (2 ml/kg) (for 1 days)107790vehicle control condition (2 ml/kg) (for 1 days)
10platelet distribution widthBDIX/CrCrlmale8.7flDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107882DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10platelet distribution widthBDIX/CrCrlmale8.6flDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107884DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10serum urea nitrogen levelBDIX/CrCrlmale35mg/dlDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107887DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10serum urea nitrogen levelBDIX/CrCrlmale34.5mg/dlDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107889DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
17left kidney wet weight to body weight ratioWKYmale9.9mg/gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition107456unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) vehicle control condition
10mean platelet volumeBDIX/CrCrlmale5.9flDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107821DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10mean platelet volumeBDIX/CrCrlmale5.9flDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107823DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10total white blood cell countBDIX/CrCrlmale12.9x 1000 cells/ulDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107826DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10total white blood cell countBDIX/CrCrlmale10x 1000 cells/ulDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107828DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10blood hemoglobin levelBDIX/CrCrlmale19.9g/dlDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107831DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10blood hemoglobin levelBDIX/CrCrlmale18.9g/dlDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107833DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
N/Akidney total tubule cast countSHRSP/A3Nmale349/sectioncontrolled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days)107555controlled sodium chloride content drinking water (1 %) (between 42 and 77 days)controlled fat content diet (24.5 %) (between 42 and 77 days)vehicle control condition (between 42 and 77 days)
N/Arenal fibrosis foci countSHRSP/A3Nmale16.4/sectioncontrolled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days)107559controlled sodium chloride content drinking water (1 %) (between 42 and 77 days)controlled fat content diet (24.5 %) (between 42 and 77 days)vehicle control condition (between 42 and 77 days)
10systolic blood pressureSS/NEisSlcnot specified137mmHgvehicle control condition (for 547.5 days)106791vehicle control condition (for 547.5 days)
10heart weight to body weight ratioSS/NEisSlcnot specified3.2g/kgvehicle control condition (for 547.5 days)106792vehicle control condition (for 547.5 days)
17body weightWKYmale256gunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition107446unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) vehicle control condition
17heart weight to body weight ratioWKYmale3.5g/kgunilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition107451unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) vehicle control condition
17kidney glomerular surface areaWKYmale19.3x 10E3 um2unilateral nephrectomy (for 150 days) then streptozotocin (35 mg/kg) then vehicle control condition107461unilateral nephrectomy (for 150 days)streptozotocin (35 mg/kg) vehicle control condition
10thymus weight to body weight ratioWAG/Novmale0.77mg/gvehicle control condition (2 ml/kg) (for 1 days)107688vehicle control condition (2 ml/kg) (for 1 days)
10thymus weight to body weight ratioISIAHmale1.95mg/gvehicle control condition (2 ml/kg) (for 1 days)107689vehicle control condition (2 ml/kg) (for 1 days)
10thymocyte countWAG/Novmale1028.62x10E6/organvehicle control condition (2 ml/kg) (for 1 days)107693vehicle control condition (2 ml/kg) (for 1 days)
10red blood cell countBDIX/CrCrlmale11x 10E6 cells/ulDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107801DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10mean corpuscular volumeBDIX/CrCrlmale47.5flDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107806DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10mean corpuscular volumeBDIX/CrCrlmale47.5flDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107808DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10hematocritBDIX/CrCrlmale52.3%DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107811DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10hematocritBDIX/CrCrlmale51%DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107813DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
11kidney glomerular tuft surface areaWKYmale8.7x 10E3 um2unilateral nephrectomy (for 150 days) then vehicle control condition107510unilateral nephrectomy (for 150 days)vehicle control condition
10spleen cell countWAG/Novmale707.11x10E6/organvehicle control condition (2 ml/kg) (for 1 days)107700vehicle control condition (2 ml/kg) (for 1 days)
10spleen cell countISIAHmale583.56x10E6/organvehicle control condition (2 ml/kg) (for 1 days)107703vehicle control condition (2 ml/kg) (for 1 days)
10apoptotic hypodiploid thymocyte count to total thymocyte count ratioWAG/Novmale0.45%vehicle control condition (2 ml/kg) (for 1 days)107706vehicle control condition (2 ml/kg) (for 1 days)
10G0 stage diploid thymocyte count to total thymocyte count ratioWAG/Novmale93.31%vehicle control condition (2 ml/kg) (for 1 days)107709vehicle control condition (2 ml/kg) (for 1 days)
10G2/M stage tetraploid thymocyte count to total thymocyte count ratioWAG/Novmale2.62%vehicle control condition (2 ml/kg) (for 1 days)107712vehicle control condition (2 ml/kg) (for 1 days)
16body weightWAGmale272.4gCC531 cells (5 X 10E6) (for 21 days) then vehicle control condition (1 ml) (for 21 days)107872CC531 cells (5 X 10E6) (for 21 days)vehicle control condition (1 ml) (for 21 days)
16metastatic intraperitoneal tumor weightWAG/OlaHsdmale7.42gCC531 cells (5 X 10E6) (for 21 days) then vehicle control condition (1 ml) (for 21 days)107874CC531 cells (5 X 10E6) (for 21 days)vehicle control condition (1 ml) (for 21 days)
10serum total cholesterol levelBDIX/CrCrlmale40.5mg/dlDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107894DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10serum alanine aminotransferase activity levelBDIX/CrCrlmale59.2U/lDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107907DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10serum alanine aminotransferase activity levelBDIX/CrCrlmale44.8U/lDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107909DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10serum alkaline phosphatase activity levelBDIX/CrCrlmale476U/lDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107912DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10serum amylase activity levelBDIX/CrCrlmale3096U/lDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107944DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
11body weightWKYmale408gunilateral nephrectomy (for 150 days) then vehicle control condition107445unilateral nephrectomy (for 150 days)vehicle control condition
11heart weight to body weight ratioWKYmale2.4g/kgunilateral nephrectomy (for 150 days) then vehicle control condition107450unilateral nephrectomy (for 150 days)vehicle control condition
10red blood cell countBDIX/CrCrlmale10.7x 10E6 cells/ulDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107803DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10thymus weight to body weight ratioSDfemale1.5mg/gvehicle control condition (5 ml/kg) (for 28 days)105884vehicle control condition (5 ml/kg) (for 28 days)
10thymus weight to body weight ratioSD-Ahrem2Sagefemale1.61mg/gvehicle control condition (5 ml/kg) (for 28 days)105885vehicle control condition (5 ml/kg) (for 28 days)
10spleen weight to body weight ratioSDfemale0.299%vehicle control condition (5 ml/kg) (for 28 days)105896vehicle control condition (5 ml/kg) (for 28 days)
10spleen weight to body weight ratioSD-Ahrem2Sagefemale0.286%vehicle control condition (5 ml/kg) (for 28 days)105897vehicle control condition (5 ml/kg) (for 28 days)
10brain weight to body weight ratioSDfemale0.742%vehicle control condition (5 ml/kg) (for 28 days)105908vehicle control condition (5 ml/kg) (for 28 days)
10brain weight to body weight ratioSD-Ahrem2Sagefemale0.742%vehicle control condition (5 ml/kg) (for 28 days)105909vehicle control condition (5 ml/kg) (for 28 days)
10both ovaries weight to body weight ratioSDfemale0.049%vehicle control condition (5 ml/kg) (for 28 days)105920vehicle control condition (5 ml/kg) (for 28 days)
10both ovaries weight to body weight ratioSD-Ahrem2Sagefemale0.047%vehicle control condition (5 ml/kg) (for 28 days)105921vehicle control condition (5 ml/kg) (for 28 days)
10red blood cell countSDfemale7.47x 10E6 cells/ulvehicle control condition (5 ml/kg) (for 28 days)105932vehicle control condition (5 ml/kg) (for 28 days)
10red blood cell countSD-Ahrem2Sagefemale7.41x 10E6 cells/ulvehicle control condition (5 ml/kg) (for 28 days)105933vehicle control condition (5 ml/kg) (for 28 days)
10hemoglobin concentrationSDfemale2.17775mmol/lvehicle control condition (5 ml/kg) (for 28 days)105944vehicle control condition (5 ml/kg) (for 28 days)
10hemoglobin concentrationSD-Ahrem2Sagefemale2.17155mmol/lvehicle control condition (5 ml/kg) (for 28 days)105945vehicle control condition (5 ml/kg) (for 28 days)
10hematocritSDfemale43.31%vehicle control condition (5 ml/kg) (for 28 days)105956vehicle control condition (5 ml/kg) (for 28 days)
10hematocritSD-Ahrem2Sagefemale43.31%vehicle control condition (5 ml/kg) (for 28 days)105957vehicle control condition (5 ml/kg) (for 28 days)
10mean corpuscular volumeSDfemale57.96flvehicle control condition (5 ml/kg) (for 28 days)105968vehicle control condition (5 ml/kg) (for 28 days)
10mean corpuscular volumeSD-Ahrem2Sagefemale58.44flvehicle control condition (5 ml/kg) (for 28 days)105969vehicle control condition (5 ml/kg) (for 28 days)
10mean corpuscular hemoglobin levelSDfemale18.82pgvehicle control condition (5 ml/kg) (for 28 days)105980vehicle control condition (5 ml/kg) (for 28 days)
10mean corpuscular hemoglobin levelSD-Ahrem2Sagefemale18.92pgvehicle control condition (5 ml/kg) (for 28 days)105981vehicle control condition (5 ml/kg) (for 28 days)
10mean corpuscular hemoglobin concentrationSDfemale32.48g/dlvehicle control condition (5 ml/kg) (for 28 days)105992vehicle control condition (5 ml/kg) (for 28 days)
10mean corpuscular hemoglobin concentrationSD-Ahrem2Sagefemale32.37g/dlvehicle control condition (5 ml/kg) (for 28 days)105993vehicle control condition (5 ml/kg) (for 28 days)
10platelet distribution width (percentage)BDIX/CrCrlmale5.2%DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 108146DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10platelet distribution width (percentage)BDIX/CrCrlmale8.5%DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 108148DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10platelet countSDfemale1308.4x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106004vehicle control condition (5 ml/kg) (for 28 days)
10platelet countSD-Ahrem2Sagefemale1388x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106005vehicle control condition (5 ml/kg) (for 28 days)
10white blood cell countSDfemale9.42x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106016vehicle control condition (5 ml/kg) (for 28 days)
10white blood cell countSD-Ahrem2Sagefemale10.8x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106017vehicle control condition (5 ml/kg) (for 28 days)
10blood neutrophil countSDfemale1.48x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106028vehicle control condition (5 ml/kg) (for 28 days)
10blood neutrophil countSD-Ahrem2Sagefemale1.89x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106029vehicle control condition (5 ml/kg) (for 28 days)
10blood lymphocyte countSDfemale7.36x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106040vehicle control condition (5 ml/kg) (for 28 days)
10blood lymphocyte countSD-Ahrem2Sagefemale8.25x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106041vehicle control condition (5 ml/kg) (for 28 days)
10blood monocyte countSDfemale0.29x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106052vehicle control condition (5 ml/kg) (for 28 days)
10blood monocyte countSD-Ahrem2Sagefemale0.31x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106053vehicle control condition (5 ml/kg) (for 28 days)
10blood eosinophil countSDfemale0.13x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106064vehicle control condition (5 ml/kg) (for 28 days)
10blood eosinophil countSD-Ahrem2Sagefemale0.18x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106065vehicle control condition (5 ml/kg) (for 28 days)
10blood basophil countSDfemale0.07x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106076vehicle control condition (5 ml/kg) (for 28 days)
10blood basophil countSD-Ahrem2Sagefemale0.08x 1000 cells/ulvehicle control condition (5 ml/kg) (for 28 days)106077vehicle control condition (5 ml/kg) (for 28 days)
10serum total cholesterol levelBDIX/CrCrlmale60mg/dlDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107892DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10serum alkaline phosphatase activity levelBDIX/CrCrlmale620U/lDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107914DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10CD3+ thymocyte countWAG/Novmale1021.26x10E6/organvehicle control condition (2 ml/kg) (for 1 days)107715vehicle control condition (2 ml/kg) (for 1 days)
10CD4+CD8- thymocyte countWAG/Novmale239.75x 10E6/organvehicle control condition (2 ml/kg) (for 1 days)107718vehicle control condition (2 ml/kg) (for 1 days)
10CD4+CD8+ thymocyte countWAG/Novmale596.53x10E6/organvehicle control condition (2 ml/kg) (for 1 days)107721vehicle control condition (2 ml/kg) (for 1 days)
10CD4-CD8+ thymocyte countWAG/Novmale74.18x10E6/organvehicle control condition (2 ml/kg) (for 1 days)107724vehicle control condition (2 ml/kg) (for 1 days)
10CD4+CD25+ thymocyte countWAG/Novmale40.63x10E6/organvehicle control condition (2 ml/kg) (for 1 days)107727vehicle control condition (2 ml/kg) (for 1 days)
10CD3+ splenocyte count to total splenocyte count ratioWAG/Novmale30.13%vehicle control condition (2 ml/kg) (for 1 days)107733vehicle control condition (2 ml/kg) (for 1 days)
10CD11b/c+ splenocyte count to total splenocyte count ratioWAG/Novmale12.4%vehicle control condition (2 ml/kg) (for 1 days)107736vehicle control condition (2 ml/kg) (for 1 days)
10CD11b/c+ splenocyte countWAG/Novmale92.63x10E6/organvehicle control condition (2 ml/kg) (for 1 days)107739vehicle control condition (2 ml/kg) (for 1 days)
10CD4+CD25+ splenocyte count to total splenocyte count ratioISIAHmale1.7%vehicle control condition (2 ml/kg) (for 1 days)107742vehicle control condition (2 ml/kg) (for 1 days)
10CD45RA+ splenocyte count to total splenocyte count ratioISIAHmale34.86%vehicle control condition (2 ml/kg) (for 1 days)107745vehicle control condition (2 ml/kg) (for 1 days)
10CD11b/c+ splenocyte count to total splenocyte count ratioISIAHmale8.4%vehicle control condition (2 ml/kg) (for 1 days)107748vehicle control condition (2 ml/kg) (for 1 days)
10CD4+CD25+ splenocyte countISIAHmale9.83x10E6/organvehicle control condition (2 ml/kg) (for 1 days)107751vehicle control condition (2 ml/kg) (for 1 days)
10CD4-CD25+ splenocyte countISIAHmale3.21x 10E6/organvehicle control condition (2 ml/kg) (for 1 days)107754vehicle control condition (2 ml/kg) (for 1 days)
10CD3+ splenocyte countISIAHmale214.09x10E6/organvehicle control condition (2 ml/kg) (for 1 days)107757vehicle control condition (2 ml/kg) (for 1 days)
10CD11b/c+ splenocyte countISIAHmale50.17x10E6/organvehicle control condition (2 ml/kg) (for 1 days)107760vehicle control condition (2 ml/kg) (for 1 days)
10CD3+ thymocyte countISIAHmale716.82x10E6/organvehicle control condition (2 ml/kg) (for 1 days)107763vehicle control condition (2 ml/kg) (for 1 days)
10CD4+CD8+ thymocyte countISIAHmale419x10E6/organvehicle control condition (2 ml/kg) (for 1 days)107766vehicle control condition (2 ml/kg) (for 1 days)
8lumen diameter at maximum constriction expressed as percent of baselineSS/JrHsdMcwinot specified75.9%controlled sodium content diet (1 %) (between 70 and 91 days) then pentobarbital (50 mg/kg) then vehicle control condition (for 0.1 hours) then Adenosine triphosphate (100 umol/l) (for 0.1 hours)106499controlled sodium content diet (1 %) (between 70 and 91 days)pentobarbital (50 mg/kg) vehicle control condition (for 0.1 hours)Adenosine triphosphate (100 umol/l) (for 0.1 hours)
10timed urine volume to body weight ratioSS/NEisSlcnot specified0.0218736ul/min/gvehicle control condition (for 547.5 days)107429vehicle control condition (for 547.5 days)
10urine sodium excretion rate to body weight ratioSS/NEisSlcnot specified0.0038192uEq/min/gvehicle control condition (for 547.5 days)107433vehicle control condition (for 547.5 days)
10serum triglyceride levelBDIX/CrCrlmale249mg/dlDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107899DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
3quinidine uptake index in retinaSDmale212%tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106114tritiated quinidine (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3digoxin uptake index in retinaSDmale24%tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106117tritiated digoxin (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3verapamil uptake index in retinaSDmale336%tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106120tritiated verapamil (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3quinidine uptake index in retinaSD-Abcb1aem1Sage-/-male227%tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106123tritiated quinidine (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3digoxin uptake index in retinaSD-Abcb1aem1Sage-/-male88%tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106126tritiated digoxin (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3verapamil uptake index in retinaSD-Abcb1aem1Sage-/-male536%tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106129tritiated verapamil (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3quinidine uptake index in aqueous humorSDmale5.95%tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106132tritiated quinidine (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3digoxin uptake index in aqueous humorSD-Abcb1aem1Sage-/-male55.9%tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106144tritiated digoxin (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3verapamil uptake index in aqueous humorSD-Abcb1aem1Sage-/-male24.8%tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106147tritiated verapamil (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3quinidine uptake index in brainSDmale2.12%tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106150tritiated quinidine (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3digoxin uptake index in brainSDmale0.987%tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106153tritiated digoxin (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3verapamil uptake index in brainSDmale9.07%tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106156tritiated verapamil (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3quinidine uptake index in brainSD-Abcb1aem1Sage-/-male26.1%tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition106159tritiated quinidine (10 uCi) (for 0 hours)vehicle control condition
10creatinine clearance to body weight ratioSS/NEisSlcnot specified0.38241ml/min/100gvehicle control condition (for 547.5 days)107441vehicle control condition (for 547.5 days)
10time to first movement outside a discrete space in an experimental apparatusSS/NEisSlcnot specified235svehicle control condition (for 547.5 days) then tactile electric shock exposure (500 mA) (for 0 hours)107468vehicle control condition (for 547.5 days)tactile electric shock exposure (500 mA) (for 0 hours)
10total serum bilirubin levelBDIX/CrCrlmale0.4mg/dlDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107924DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10total serum bilirubin levelBDIX/CrCrlmale0.35mg/dlDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107926DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10serum lactate dehydrogenase activity levelBDIX/CrCrlmale964U/lDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107929DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10serum lactate dehydrogenase activity levelBDIX/CrCrlmale2717U/lDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107931DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
4serum interleukin-4 levelSDnot specified0.14ug/lvehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days)105411vehicle control conditionacetic acid (for 0 hours)physical restraint in tube type rodent restrainer (for 2 hours)fasting (for 1 days)
4serum interleukin-9 levelSDnot specified0.1ug/lvehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days)105415vehicle control conditionacetic acid (for 0 hours)physical restraint in tube type rodent restrainer (for 2 hours)fasting (for 1 days)
4intestine trypsin levelSDnot specified0.17ug/lvehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days)105419vehicle control conditionacetic acid (for 0 hours)physical restraint in tube type rodent restrainer (for 2 hours)fasting (for 1 days)
5retinal outer nuclear layer thicknessCrl:CD(SD)male41umvehicle control condition (0 mg/kg) (for 5 days)105434vehicle control condition (0 mg/kg) (for 5 days)
5retinal outer layer thicknessCrl:CD(SD)male142.2umvehicle control condition (0 mg/kg) (for 5 days)105466vehicle control condition (0 mg/kg) (for 5 days)
5retinal outer layer thicknessCrl:CD(SD)male138.5umvehicle control condition (0 mg/kg) (for 13 days)105474vehicle control condition (0 mg/kg) (for 13 days)
10retinal outer layer thicknessCrl:CD(SD)male136umvehicle control condition (0 mg/kg) (for 26 days)105482vehicle control condition (0 mg/kg) (for 26 days)
10liver weight as percentage of body weightSDfemale3.647%vehicle control condition (5 ml/kg) (for 28 days)105720vehicle control condition (5 ml/kg) (for 28 days)
10liver weight as percentage of body weightSD-Ahrem2Sagefemale3.428%vehicle control condition (5 ml/kg) (for 28 days)105726vehicle control condition (5 ml/kg) (for 28 days)
6lumen diameter at maximum constriction expressed as percent of baselineSS-Chr 2BN/Mcwinot specified80.2%controlled sodium content diet (1 %) (between 70 and 91 days) then pentobarbital (50 mg/kg) then vehicle control condition (for 0.1 hours) then Adenosine triphosphate (100 umol/l) (for 0.1 hours)106500controlled sodium content diet (1 %) (between 70 and 91 days)pentobarbital (50 mg/kg) vehicle control condition (for 0.1 hours)Adenosine triphosphate (100 umol/l) (for 0.1 hours)
10lumen diameter at maximum constriction expressed as percent of baselineSS-Shc1em1Mcwinot specified78.6%controlled sodium content diet (1 %) (between 70 and 91 days) then pentobarbital (50 mg/kg) then vehicle control condition (for 0.1 hours) then Adenosine triphosphate (100 umol/l) (for 0.1 hours)106501controlled sodium content diet (1 %) (between 70 and 91 days)pentobarbital (50 mg/kg) vehicle control condition (for 0.1 hours)Adenosine triphosphate (100 umol/l) (for 0.1 hours)
4lumen diameter at maximum constriction expressed as percent of baselineSS-Shc1em4Mcwinot specified75.9%controlled sodium content diet (1 %) (between 70 and 91 days) then pentobarbital (50 mg/kg) then vehicle control condition (for 0.1 hours) then Adenosine triphosphate (100 umol/l) (for 0.1 hours)106502controlled sodium content diet (1 %) (between 70 and 91 days)pentobarbital (50 mg/kg) vehicle control condition (for 0.1 hours)Adenosine triphosphate (100 umol/l) (for 0.1 hours)
5lumen diameter at maximum constriction expressed as percent of baselineSS-Shc1em5Mcwinot specified75.5%controlled sodium content diet (1 %) (between 70 and 91 days) then pentobarbital (50 mg/kg) then vehicle control condition (for 0.1 hours) then Adenosine triphosphate (100 umol/l) (for 0.1 hours)106503controlled sodium content diet (1 %) (between 70 and 91 days)pentobarbital (50 mg/kg) vehicle control condition (for 0.1 hours)Adenosine triphosphate (100 umol/l) (for 0.1 hours)
10lumen diameter at maximum constriction expressed as percent of baselineSS/JrHsdMcwinot specified75.4%controlled sodium content diet (1 %) (between 70 and 91 days) then pentobarbital (50 mg/kg) then vehicle control condition (for 0.1 hours) then Endothelin-1 (10 umol/l) (for 0.1 hours)106504controlled sodium content diet (1 %) (between 70 and 91 days)pentobarbital (50 mg/kg) vehicle control condition (for 0.1 hours)Endothelin-1 (10 umol/l) (for 0.1 hours)
6lumen diameter at maximum constriction expressed as percent of baselineSS-Chr 2BN/Mcwinot specified79.3%controlled sodium content diet (1 %) (between 70 and 91 days) then pentobarbital (50 mg/kg) then vehicle control condition (for 0.1 hours) then Endothelin-1 (10 umol/l) (for 0.1 hours)106505controlled sodium content diet (1 %) (between 70 and 91 days)pentobarbital (50 mg/kg) vehicle control condition (for 0.1 hours)Endothelin-1 (10 umol/l) (for 0.1 hours)
7lumen diameter at maximum constriction expressed as percent of baselineSS-Shc1em4Mcwinot specified76.1%controlled sodium content diet (1 %) (between 70 and 91 days) then pentobarbital (50 mg/kg) then vehicle control condition (for 0.1 hours) then Endothelin-1 (10 umol/l) (for 0.1 hours)106506controlled sodium content diet (1 %) (between 70 and 91 days)pentobarbital (50 mg/kg) vehicle control condition (for 0.1 hours)Endothelin-1 (10 umol/l) (for 0.1 hours)
8lumen diameter at maximum constriction expressed as percent of baselineSS-Shc1em5Mcwinot specified75.5%controlled sodium content diet (1 %) (between 70 and 91 days) then pentobarbital (50 mg/kg) then vehicle control condition (for 0.1 hours) then Endothelin-1 (10 umol/l) (for 0.1 hours)106507controlled sodium content diet (1 %) (between 70 and 91 days)pentobarbital (50 mg/kg) vehicle control condition (for 0.1 hours)Endothelin-1 (10 umol/l) (for 0.1 hours)
3digoxin uptake index in brainSD-Abcb1aem1Sage-/-male14%tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition106162tritiated digoxin (10 uCi) (for 0 hours)vehicle control condition
3verapamil uptake index in brainSD-Abcb1aem1Sage-/-male75%tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition106165tritiated verapamil (10 uCi) (for 0 hours)vehicle control condition
10serum NAG activity levelSS/NEisSlcnot specified20.1uU/mlvehicle control condition (for 547.5 days)107425vehicle control condition (for 547.5 days)
10CD4-CD8+ thymocyte countISIAHmale63.99x10E6/organvehicle control condition (2 ml/kg) (for 1 days)107769vehicle control condition (2 ml/kg) (for 1 days)
10CD4+CD25+ thymocyte countISIAHmale32.19x10E6/organvehicle control condition (2 ml/kg) (for 1 days)107772vehicle control condition (2 ml/kg) (for 1 days)
10plasma triglyceride levelWAG/Novmale1.1865mmol/lvehicle control condition (2 ml/kg) (for 1 days)107775vehicle control condition (2 ml/kg) (for 1 days)
10plasma triglyceride levelISIAHmale1.2995mmol/lvehicle control condition (2 ml/kg) (for 1 days)107778vehicle control condition (2 ml/kg) (for 1 days)
5retinal outer nuclear layer thicknessCrl:CD(SD)male53.4umvehicle control condition (0 mg/kg) (for 25 days)105442vehicle control condition (0 mg/kg) (for 25 days)
5retinal outer nuclear layer photoreceptor nucleus countCrl:CD(SD)male10.5vehicle control condition (for 25 days)105462vehicle control condition (for 25 days)
10retinal inner layer thicknessCrl:CD(SD)male126umvehicle control condition (0 mg/kg) (for 26 days)105486vehicle control condition (0 mg/kg) (for 26 days)
5retinal outer layer thicknessCrl:CD(SD)male132.2umvehicle control condition (0 mg/kg) (for 25 days)105490vehicle control condition (0 mg/kg) (for 25 days)
5retinal outer layer thicknessCrl:CD(SD)male129.8umvehicle control condition (0 mg/kg) (for 25 days)105498vehicle control condition (0 mg/kg) (for 25 days)
5retinal inner layer thicknessCrl:CD(SD)male123.8umvehicle control condition (0 mg/kg) (for 25 days)105502vehicle control condition (0 mg/kg) (for 25 days)
5full retina thicknessCrl:CD(SD)male129.7umvehicle control condition (0 mg/kg) (for 5 days)105438vehicle control condition (0 mg/kg) (for 5 days)
5retinal outer nuclear layer photoreceptor nucleus countCrl:CD(SD)male11.3vehicle control condition (0 mg/kg) (for 25 days)105450vehicle control condition (0 mg/kg) (for 25 days)
5retinal outer nuclear layer thicknessCrl:CD(SD)male50.6umvehicle control condition (for 25 days)105454vehicle control condition (for 25 days)
5full retina thicknessCrl:CD(SD)male191.6umvehicle control condition (0 mg/kg) (for 25 days)105458vehicle control condition (0 mg/kg) (for 25 days)
5retinal inner layer thicknessCrl:CD(SD)male131.6umvehicle control condition (0 mg/kg) (for 5 days)105470vehicle control condition (0 mg/kg) (for 5 days)
5retinal inner layer thicknessCrl:CD(SD)male128.7umvehicle control condition (0 mg/kg) (for 13 days)105478vehicle control condition (0 mg/kg) (for 13 days)
5retinal inner layer thicknessCrl:CD(SD)male121.9umvehicle control condition (0 mg/kg) (for 25 days)105494vehicle control condition (0 mg/kg) (for 25 days)
6cerebrum infarct volume to total cerebrum volume ratioF344-Pde4dTn(sb-T2/Bart3)2.285Mcwimale20%isoflurane (1.5 %) (for 4 hours) then vehicle control condition then middle cerebral artery occlusion (for 1 hours)106360isoflurane (1.5 %) (for 4 hours)vehicle control conditionmiddle cerebral artery occlusion (for 1 hours)
4serum total immunoglobulin E levelSDnot specified0.2ug/lvehicle control condition then acetic acid (for 0 hours) then physical restraint in tube type rodent restrainer (for 2 hours) then fasting (for 1 days)105407vehicle control conditionacetic acid (for 0 hours)physical restraint in tube type rodent restrainer (for 2 hours)fasting (for 1 days)
5full retina thicknessCrl:CD(SD)male177.2umvehicle control condition (0 mg/kg) (for 25 days)105446vehicle control condition (0 mg/kg) (for 25 days)
4measurement of the 50% threshold of mechanical stimulus needed to elicit evasive reactionF344male2.88gvehicle control condition105566vehicle control condition
12percentage of survivors in a study population during a period of timeSHRSP/A3NCrlmale50%controlled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days)109030controlled sodium chloride content drinking water (1 %) (for 91 days)controlled fat content diet (24.5 %) (for 91 days)vehicle control condition (for 35 days)
3verapamil uptake index in aqueous humorSDmale8.46%tritiated verapamil (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106138tritiated verapamil (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
3quinidine uptake index in aqueous humorSD-Abcb1aem1Sage-/-male12%tritiated quinidine (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours)106141tritiated quinidine (10 uCi) (for 0 hours)vehicle control condition (for 0 hours)
16cerebrum infarct volume to total cerebrum volume ratioWImale23%isoflurane (1.5 %) (for 4 hours) then vehicle control condition then Embolism injection at middle cerebral artery (for 1 days)106358isoflurane (1.5 %) (for 4 hours)vehicle control conditionEmbolism injection at middle cerebral artery (for 1 days)
18cerebrum infarct volume to total cerebrum volume ratioF344male11%isoflurane (1.5 %) (for 4 hours) then vehicle control condition then middle cerebral artery occlusion (for 1 hours)106172isoflurane (1.5 %) (for 4 hours)vehicle control conditionmiddle cerebral artery occlusion (for 1 hours)
6cerebrum infarct volume to total cerebrum volume ratioF344male18%isoflurane (1.5 %) (for 4 hours) then vehicle control condition then middle cerebral artery occlusion (for 1 hours)106361isoflurane (1.5 %) (for 4 hours)vehicle control conditionmiddle cerebral artery occlusion (for 1 hours)
7heart right ventricle weight to left ventricle plus septum weight ratioSS/JrHsdMcwimale0.25g/gvehicle control condition106536vehicle control condition
10heart right ventricle weight to left ventricle plus septum weight ratioSS-Sod3m1Mcwimale0.25g/gvehicle control condition106537vehicle control condition
7heart left ventricle weightSS/JrHsdMcwimale0.641gvehicle control condition106538vehicle control condition
10heart left ventricle weightSS-Sod3m1Mcwimale0.64gvehicle control condition106539vehicle control condition
7heart right ventricle weightSS/JrHsdMcwimale0.162gvehicle control condition106540vehicle control condition
10heart right ventricle weightSS-Sod3m1Mcwimale0.157gvehicle control condition106541vehicle control condition
7body weightSS/JrHsdMcwimale261gvehicle control condition106550vehicle control condition
10body weightSS-Sod3m1Mcwimale259gvehicle control condition106551vehicle control condition
7tibia lengthSS/JrHsdMcwimale3.64cmvehicle control condition106554vehicle control condition
10tibia lengthSS-Sod3m1Mcwimale3.64cmvehicle control condition106555vehicle control condition
7lung weightSS/JrHsdMcwimale1.23gvehicle control condition106558vehicle control condition
10lung weightSS-Sod3m1Mcwimale1.2gvehicle control condition106559vehicle control condition
7right atrium weightSS/JrHsdMcwimale0.0161gvehicle control condition106562vehicle control condition
10right atrium weightSS-Sod3m1Mcwimale0.0149gvehicle control condition106563vehicle control condition
7left atrium weightSS/JrHsdMcwimale0.0148gvehicle control condition106566vehicle control condition
10left atrium weightSS-Sod3m1Mcwimale0.0164gvehicle control condition106567vehicle control condition
7heart right atrium weight to left atrium weight ratioSS/JrHsdMcwimale1.09vehicle control condition106570vehicle control condition
10heart right atrium weight to left atrium weight ratioSS-Sod3m1Mcwimale0.94vehicle control condition106571vehicle control condition
7liver weightSS/JrHsdMcwimale10.6gvehicle control condition106574vehicle control condition
10liver weightSS-Sod3m1Mcwimale10.6gvehicle control condition106575vehicle control condition
7kidney weightSS/JrHsdMcwimale2.13gvehicle control condition106578vehicle control condition
10kidney weightSS-Sod3m1Mcwimale2.03gvehicle control condition106579vehicle control condition
7heart right ventricle weight to body weight ratioSS/JrHsdMcwimale0.62mg/gvehicle control condition106582vehicle control condition
10heart right ventricle weight to body weight ratioSS-Sod3m1Mcwimale0.61mg/gvehicle control condition106583vehicle control condition
7heart left ventricle weight to body weight ratioSS/JrHsdMcwimale2.43mg/gvehicle control condition106586vehicle control condition
10heart left ventricle weight to body weight ratioSS-Sod3m1Mcwimale2.49mg/gvehicle control condition106587vehicle control condition
7lung weight to body weight ratioSS/JrHsdMcwimale0.403%vehicle control condition106590vehicle control condition
10lung weight to body weight ratioSS-Sod3m1Mcwimale0.465%vehicle control condition106591vehicle control condition
7heart right atrium weight to body weight ratioSS/JrHsdMcwimale0.06mg/gvehicle control condition106594vehicle control condition
10heart right atrium weight to body weight ratioSS-Sod3m1Mcwimale0.06mg/gvehicle control condition106595vehicle control condition
7heart left atrium weight to body weight ratioSS/JrHsdMcwimale0.06mg/gvehicle control condition106598vehicle control condition
10heart left atrium weight to body weight ratioSS-Sod3m1Mcwimale0.06mg/gvehicle control condition106599vehicle control condition
7liver weight to body weight ratioSS/JrHsdMcwimale40.5g/kgvehicle control condition106602vehicle control condition
10liver weight to body weight ratioSS-Sod3m1Mcwimale40.9g/kgvehicle control condition106603vehicle control condition
7single kidney wet weight to body weight ratioSS/JrHsdMcwimale8.14g/kgvehicle control condition106606vehicle control condition
10single kidney wet weight to body weight ratioSS-Sod3m1Mcwimale7.83g/kgvehicle control condition106607vehicle control condition
6systolic blood pressureSHRSP/A3Nmale284mmHgcontrolled sodium chloride content drinking water (1 %) (for 84 days) and controlled fat content diet (24.5 %) (for 84 days) and vehicle control condition (for 84 days)107499controlled sodium chloride content drinking water (1 %) (for 84 days)controlled fat content diet (24.5 %) (for 84 days)vehicle control condition (for 84 days)
10blood non-specified leukocyte countISIAHmale2.9610E3/ulvehicle control condition (2 ml/kg) (for 1 days)107696vehicle control condition (2 ml/kg) (for 1 days)
N/Aboth kidneys wet weight to body weight ratioSHRSP/A3Nmale13g/kgcontrolled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days)107535controlled sodium chloride content drinking water (1 %) (between 42 and 77 days)controlled fat content diet (24.5 %) (between 42 and 77 days)vehicle control condition (between 42 and 77 days)
N/Akidney glomerular lesion countSHRSP/A3Nmale76.5/sectioncontrolled sodium chloride content drinking water (1 %) (between 42 and 77 days) and controlled fat content diet (24.5 %) (between 42 and 77 days) and vehicle control condition (between 42 and 77 days)107539controlled sodium chloride content drinking water (1 %) (between 42 and 77 days)controlled fat content diet (24.5 %) (between 42 and 77 days)vehicle control condition (between 42 and 77 days)
10mean corpuscular hemoglobin levelBDIX/CrCrlmale18pgDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107836DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10mean corpuscular hemoglobin levelBDIX/CrCrlmale17.5pgDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107838DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10mean corpuscular hemoglobin concentrationBDIX/CrCrlmale38g/dlDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107841DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10mean corpuscular hemoglobin concentrationBDIX/CrCrlmale37g/dlDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107843DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10red blood cell distribution width-coefficient of variationBDIX/CrCrlmale16.9%DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107846DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10red blood cell distribution width-coefficient of variationBDIX/CrCrlmale17.7%DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107848DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10blood lymphocyte count to total leukocyte count ratioBDIX/CrCrlmale8.1%DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107851DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10blood lymphocyte count to total leukocyte count ratioBDIX/CrCrlmale8%DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107853DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10serum triglyceride levelBDIX/CrCrlmale265mg/dlDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107897DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10serum aspartate aminotransferase activity levelBDIX/CrCrlmale139U/lDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107902DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10serum aspartate aminotransferase activity levelBDIX/CrCrlmale193U/lDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107904DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10serum amylase activity levelBDIX/CrCrlmale3190U/lDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107946DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
7heart right ventricle weight to tibia length ratioSS/JrHsdMcwimale4.51mg/mmvehicle control condition106610vehicle control condition
10heart right ventricle weight to tibia length ratioSS-Sod3m1Mcwimale4.33mg/mmvehicle control condition106611vehicle control condition
7heart left ventricle weight to tibia length ratioSS/JrHsdMcwimale0.178g/cmvehicle control condition106614vehicle control condition
10heart left ventricle weight to tibia length ratioSS-Sod3m1Mcwimale0.177g/cmvehicle control condition106615vehicle control condition
7lung weight to tibia length ratioSS/JrHsdMcwimale0.291g/cmvehicle control condition106618vehicle control condition
10lung weight to tibia length ratioSS-Sod3m1Mcwimale0.33g/cmvehicle control condition106619vehicle control condition
7heart right atrium weight to tibia length ratioSS/JrHsdMcwimale0.44mg/mmvehicle control condition106622vehicle control condition
10heart right atrium weight to tibia length ratioSS-Sod3m1Mcwimale0.41mg/mmvehicle control condition106623vehicle control condition
7heart left atrium weight to tibia length ratioSS/JrHsdMcwimale0.41mg/mmvehicle control condition106626vehicle control condition
10heart left atrium weight to tibia length ratioSS-Sod3m1Mcwimale0.45mg/mmvehicle control condition106627vehicle control condition
7liver weight to tibia length ratioSS/JrHsdMcwimale29.2mg/mmvehicle control condition106630vehicle control condition
10liver weight to tibia length ratioSS-Sod3m1Mcwimale29.1mg/mmvehicle control condition106631vehicle control condition
7single kidney weight to tibia length ratioSS/JrHsdMcwimale0.0586g/cmvehicle control condition106634vehicle control condition
10single kidney weight to tibia length ratioSS-Sod3m1Mcwimale0.0556g/cmvehicle control condition106635vehicle control condition
10neuron countSS/NEisSlcnot specified1258cells/mm2vehicle control condition (for 547.5 days)107465vehicle control condition (for 547.5 days)
11left kidney wet weight to body weight ratioWKYmale3.9mg/gunilateral nephrectomy (for 150 days) then vehicle control condition107455unilateral nephrectomy (for 150 days)vehicle control condition
11kidney glomerular surface areaWKYmale12.6x 10E3 um2unilateral nephrectomy (for 150 days) then vehicle control condition107460unilateral nephrectomy (for 150 days)vehicle control condition
10blood granulocyte count to total leukocyte count ratioBDIX/CrCrlmale1.2%DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107856DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10blood granulocyte count to total leukocyte count ratioBDIX/CrCrlmale0.8%DHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107858DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10blood lymphocyte countBDIX/CrCrlmale62.8x 1000 cells/ulDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107861DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
10blood lymphocyte countBDIX/CrCrlmale77.7x 1000 cells/ulDHD/K12/TRb cells (1.5 X 10E6) then vehicle control condition (1 ml) 107863DHD/K12/TRb cells (1.5 X 10E6) vehicle control condition (1 ml)
6time to peak measurement of Gd-DTPA uptake by kidney cortexSHRSP/A3NCrlmale14.3scontrolled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days)107374controlled sodium chloride content drinking water (1 %) (for 91 days)controlled fat content diet (24.5 %) (for 91 days)vehicle control condition (for 35 days)
6multiregional glomerular filtration rate indexSHRSP/A3NCrlmale2.25mmol/mincontrolled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (between 35 and 63 days)107379controlled sodium chloride content drinking water (1 %) (for 91 days)controlled fat content diet (24.5 %) (for 91 days)vehicle control condition (between 35 and 63 days)
6body weightSHRSP/A3NCrlmale307gcontrolled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days)107382controlled sodium chloride content drinking water (1 %) (for 91 days)controlled fat content diet (24.5 %) (for 91 days)vehicle control condition (for 35 days)
6systolic blood pressureSHRSP/A3NCrlmale162mmHgcontrolled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days)107385controlled sodium chloride content drinking water (1 %) (for 91 days)controlled fat content diet (24.5 %) (for 91 days)vehicle control condition (for 35 days)
6creatinine clearanceSHRSP/A3NCrlmale2ml/mincontrolled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days)107388controlled sodium chloride content drinking water (1 %) (for 91 days)controlled fat content diet (24.5 %) (for 91 days)vehicle control condition (for 35 days)
6blood urea nitrogen levelSHRSP/A3NCrlmale20.5mg/dlcontrolled sodium chloride content drinking water (1 %) (for 91 days) and controlled fat content diet (24.5 %) (for 91 days) then vehicle control condition (for 35 days)107391controlled sodium chloride content drinking water (1 %) (for 91 days)controlled fat content diet (24.5 %) (for 91 days)vehicle control condition (for 35 days)