12 | ejection fraction | WKY | male | 75.8 | % | sham surgical control condition (for 196 days) | 100351 | sham surgical control condition (for 196 days) | | | | | | | |

5 | ejection fraction | WKY | male | 86.8 | % | sham surgical control condition (for 224 days) | 100300 | sham surgical control condition (for 224 days) | | | | | | | |

7 | ejection fraction | SD | male | 67 | % | sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days) | 99377 | sham surgical control condition (for 28 days) | | | Aprotinin (12000 kIU) (for 28 days) | | | | |

7 | ejection fraction | SD | male | 66 | % | sham surgical control condition (for 28 days) | 99375 | sham surgical control condition (for 28 days) | | | | | | | |

5 | ejection fraction | SD | male | 72 | % | sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days) | 99373 | sham surgical control condition (for 2 days) | | | Aprotinin (12000 kIU) (for 2 days) | | | | |

5 | ejection fraction | SD | male | 66 | % | sham surgical control condition (for 2 days) | 99371 | sham surgical control condition (for 2 days) | | | | | | | |

6 | ejection fraction | SD | male | 64 | % | sham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98885 | sham surgical control condition (between 120 and 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

6 | ejection fraction | SD | male | 65 | % | sham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98883 | sham surgical control condition (for 2 days) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | | | |

6 | ejection fraction | SD | male | 63 | % | sham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98881 | sham surgical control condition (for 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

6 | ejection fraction | SD | male | 65 | % | sham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98879 | sham surgical control condition (for 6 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

5 | left ventricular end-diastolic blood pressure | WKY | male | 5.5 | mmHg | sham surgical control condition (for 224 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) | 100324 | sham surgical control condition (for 224 days) | | | ketamine (80 mg/kg) | | xylazine (10 mg/kg) | | |

7 | left ventricular end-diastolic blood pressure | SD | male | 4 | mmHg | sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days) | 99313 | sham surgical control condition (for 28 days) | | | Aprotinin (12000 kIU) (for 28 days) | | | | |

7 | left ventricular end-diastolic blood pressure | SD | male | 4.2 | mmHg | sham surgical control condition (for 28 days) | 99311 | sham surgical control condition (for 28 days) | | | | | | | |

5 | left ventricular end-diastolic blood pressure | SD | male | 5 | mmHg | sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days) | 99309 | sham surgical control condition (for 2 days) | | | Aprotinin (12000 kIU) (for 2 days) | | | | |

5 | left ventricular end-diastolic blood pressure | SD | male | 6 | mmHg | sham surgical control condition (for 2 days) | 99307 | sham surgical control condition (for 2 days) | | | | | | | |

10 | left ventricular end-diastolic blood pressure | SD | male | 5 | mmHg | sham surgical control condition (for 105 days) | 99225 | sham surgical control condition (for 105 days) | | | | | | | |

8 | left ventricular end-diastolic blood pressure | SD | male | 2 | mmHg | sham surgical control condition (for 28 days) | 99223 | sham surgical control condition (for 28 days) | | | | | | | |

6 | left ventricular end-diastolic blood pressure | SD | male | 3 | mmHg | sham surgical control condition (for 2 days) then metoprolol (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98829 | sham surgical control condition (for 2 days) | | | metoprolol (100 mg/kg/d) (for 2 days) | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | |

6 | left ventricular end-diastolic blood pressure | SD | male | 3 | mmHg | sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98827 | sham surgical control condition (for 2 days) | | | vehicle control condition (for 2 days) | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | |

6 | left ventricular end-diastolic blood pressure | SD | male | 2 | mmHg | sham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98825 | sham surgical control condition (between 120 and 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

6 | left ventricular end-diastolic blood pressure | SD | male | 2 | mmHg | sham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98823 | sham surgical control condition (for 2 days) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | | | |

6 | left ventricular end-diastolic blood pressure | SD | male | 2 | mmHg | sham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98821 | sham surgical control condition (for 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | | | |

6 | left ventricular end-diastolic blood pressure | SD | male | 5 | mmHg | sham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98819 | sham surgical control condition (for 6 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

5 | left ventricular end-diastolic blood pressure | WKY.WKHA-(D5Rat45-D5Rat245)/Cfd | female | 0.22 | mmHg | sham surgical control condition | 68859 | sham surgical control condition | | | | | | | |

5 | left ventricular end-diastolic blood pressure | WKHA/Cfd | female | 1.99 | mmHg | sham surgical control condition | 68857 | sham surgical control condition | | | | | | | |

5 | left ventricular end-diastolic blood pressure | WKY/Cfd | female | 1.66 | mmHg | sham surgical control condition | 68808 | sham surgical control condition | | | | | | | |

5 | left ventricular end-diastolic blood pressure | WKY.WKHA-(D5Rat45-D5Rat245)/Cfd | male | 0.52 | mmHg | sham surgical control condition | 68806 | sham surgical control condition | | | | | | | |

5 | left ventricular end-diastolic blood pressure | WKHA/Cfd | male | 0.23 | mmHg | sham surgical control condition | 68804 | sham surgical control condition | | | | | | | |

5 | left ventricular end-diastolic blood pressure | WKY/Cfd | male | 1.32 | mmHg | sham surgical control condition | 68802 | sham surgical control condition | | | | | | | |

9 | right kidney wet weight to body weight ratio | SHR-Chr 8MWF/Rkb | male | 3.36 | mg/g | sham surgical control condition (for 126 days) | 109558 | sham surgical control condition (for 126 days) | | | | | | | |

9 | right kidney wet weight to body weight ratio | SHR/FubRkb | male | 3.25 | mg/g | sham surgical control condition (for 126 days) | 109557 | sham surgical control condition (for 126 days) | | | | | | | |

10 | lung wet weight | WAG/RijCrl | male | 1.4 | g | S4MH cells (250 X 10E3) (for 21 days) then sham surgical control condition (for 11 days) | 108160 | S4MH cells (250 X 10E3) (for 21 days) | | | sham surgical control condition (for 11 days) | | | | |

12 | lung wet weight | WKY | male | 1.779 | g | sham surgical control condition (for 196 days) | 100297 | sham surgical control condition (for 196 days) | | | | | | | |

6 | heart weight | SD | male | 1.41 | g | sham surgical control condition (for 140 days) | 101082 | sham surgical control condition (for 140 days) | | | | | | | |

6 | heart weight | SD | male | 1.13 | g | sham surgical control condition (for 28 days) | 101080 | sham surgical control condition (for 28 days) | | | | | | | |

5 | heart weight | WKY | male | 1.266 | g | sham surgical control condition (for 224 days) | 100279 | sham surgical control condition (for 224 days) | | | | | | | |

12 | heart weight | WKY | male | 1.187 | g | sham surgical control condition (for 196 days) | 100276 | sham surgical control condition (for 196 days) | | | | | | | |

10 | heart weight | SD | male | 1.26 | g | sham surgical control condition (for 105 days) | 99197 | sham surgical control condition (for 105 days) | | | | | | | |

8 | heart weight | SD | male | 0.98 | g | sham surgical control condition (for 28 days) | 99195 | sham surgical control condition (for 28 days) | | | | | | | |

10 | heart weight to body weight ratio | SD | male | 2.7 | g/kg | sham surgical control condition (for 105 days) | 99201 | sham surgical control condition (for 105 days) | | | | | | | |

8 | heart weight to body weight ratio | SD | male | 2.7 | g/kg | sham surgical control condition (for 28 days) | 99199 | sham surgical control condition (for 28 days) | | | | | | | |

6 | heart weight to body weight ratio | SD | male | 3.4 | g/kg | sham surgical control condition (between 120 and 12 hours) | 98784 | sham surgical control condition (between 120 and 12 hours) | | | | | | | |

6 | heart weight to body weight ratio | SD | male | 3.3 | g/kg | sham surgical control condition (for 2 days) | 98782 | sham surgical control condition (for 2 days) | | | | | | | |

6 | heart weight to body weight ratio | SD | male | 3.4 | g/kg | sham surgical control condition (for 12 hours) | 98780 | sham surgical control condition (for 12 hours) | | | | | | | |

6 | heart weight to body weight ratio | SD | male | 3.3 | g/kg | sham surgical control condition (for 6 hours) | 98778 | sham surgical control condition (for 6 hours) | | | | | | | |

N/A | mean arterial blood pressure | SS/JrHsd | female | 129 | mmHg | controlled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) | 102210 | controlled sodium chloride content diet (0.4 %) (for 14 days) | | | sham surgical control condition | | peanut oil (0.2 ml) (for 14 days) | | |

N/A | mean arterial blood pressure | SR/JrHsd | female | 122 | mmHg | controlled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) | 102207 | controlled sodium chloride content diet (0.4 %) (for 14 days) | | | sham surgical control condition | | peanut oil (0.2 ml) (for 14 days) | | |

7 | mean arterial blood pressure | SD | male | 106 | mmHg | sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days) | 99305 | sham surgical control condition (for 28 days) | | | Aprotinin (12000 kIU) (for 28 days) | | | | |

7 | mean arterial blood pressure | SD | male | 107 | mmHg | sham surgical control condition (for 28 days) | 99303 | sham surgical control condition (for 28 days) | | | | | | | |

5 | mean arterial blood pressure | SD | male | 106 | mmHg | sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days) | 99301 | sham surgical control condition (for 2 days) | | | Aprotinin (12000 kIU) (for 2 days) | | | | |

5 | mean arterial blood pressure | SD | male | 100 | mmHg | sham surgical control condition (for 2 days) | 99299 | sham surgical control condition (for 2 days) | | | | | | | |

10 | mean arterial blood pressure | SD | male | 95 | mmHg | sham surgical control condition (for 105 days) | 99221 | sham surgical control condition (for 105 days) | | | | | | | |

8 | mean arterial blood pressure | SD | male | 114 | mmHg | sham surgical control condition (for 28 days) | 99219 | sham surgical control condition (for 28 days) | | | | | | | |

14 | mean arterial blood pressure | Crl:WI(WU) | male | 103 | mmHg | sham surgical control condition | 100021 | sham surgical control condition | | | | | | | |

14 | mean arterial blood pressure | Crl:WI(WU) | male | 105 | mmHg | sham surgical control condition | 100013 | sham surgical control condition | | | | | | | |

6 | mean arterial blood pressure | SD | male | 82 | mmHg | sham surgical control condition (for 2 days) then metoprolol (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98817 | sham surgical control condition (for 2 days) | | | metoprolol (100 mg/kg/d) (for 2 days) | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | |

6 | mean arterial blood pressure | SD | male | 86 | mmHg | sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98815 | sham surgical control condition (for 2 days) | | | vehicle control condition (for 2 days) | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | |

6 | mean arterial blood pressure | SD | male | 85 | mmHg | sham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98813 | sham surgical control condition (between 120 and 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

6 | mean arterial blood pressure | SD | male | 76 | mmHg | sham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98811 | sham surgical control condition (for 2 days) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | | | |

6 | mean arterial blood pressure | SD | male | 90 | mmHg | sham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98809 | sham surgical control condition (for 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

6 | mean arterial blood pressure | SD | male | 103 | mmHg | sham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98807 | sham surgical control condition (for 6 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

6 | heart right ventricle weight to body weight ratio | SD | male | 0.51 | mg/g | sham surgical control condition (for 140 days) | 101106 | sham surgical control condition (for 140 days) | | | | | | | |

6 | heart right ventricle weight to body weight ratio | SD | male | 0.59 | mg/g | sham surgical control condition (for 28 days) | 101104 | sham surgical control condition (for 28 days) | | | | | | | |

5 | body weight gain | MW | male | 23 | g | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101343 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

6 | body weight gain | MW | male | 8 | g | losartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101341 | losartan (10 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | body weight gain | MW | male | 6 | g | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101339 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | body weight gain | MW | male | -1 | g | losartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101337 | losartan (10 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | body weight gain | MW | male | -6 | g | vehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101335 | vehicle control condition (0 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

6 | body weight gain | MW | male | -5 | g | losartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101333 | losartan (10 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

5 | body weight gain | MW | male | 34 | g | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101329 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | body weight gain | MW | male | 30 | g | ramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101327 | ramipril (3 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | body weight gain | MW | male | 18 | g | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101325 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

5 | body weight gain | MW | male | 20 | g | ramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101323 | ramipril (3 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

7 | urine sodium excretion rate | MW | male | 1.28 | mEq/d | sham surgical control condition (for 28 days) | 101047 | sham surgical control condition (for 28 days) | | | | | | | |

6 | blood glucose level | GK | female | 172 | mg/dl | sham surgical control condition (for 24 days) then fasting (for 12 hours) | 103759 | sham surgical control condition (for 24 days) | | | fasting (for 12 hours) | | | | |

6 | blood glucose level | Crl:WI(Han) | female | 105 | mg/dl | sham surgical control condition (for 24 days) then fasting (for 12 hours) | 103757 | sham surgical control condition (for 24 days) | | | fasting (for 12 hours) | | | | |

6 | heart weight to body weight ratio | SD | male | 2.66 | g/kg | sham surgical control condition (for 140 days) | 101086 | sham surgical control condition (for 140 days) | | | | | | | |

6 | heart weight to body weight ratio | SD | male | 2.92 | g/kg | sham surgical control condition (for 28 days) | 101084 | sham surgical control condition (for 28 days) | | | | | | | |

6 | heart weight to body weight ratio | GK | female | 4 | g/kg | sham surgical control condition (for 24 days) | 103779 | sham surgical control condition (for 24 days) | | | | | | | |

6 | heart weight to body weight ratio | Crl:WI(Han) | female | 3.2 | g/kg | sham surgical control condition (for 24 days) | 103777 | sham surgical control condition (for 24 days) | | | | | | | |

6 | heart left ventricle weight to body weight ratio | SD | male | 1.44 | mg/g | sham surgical control condition (for 140 days) | 101098 | sham surgical control condition (for 140 days) | | | | | | | |

6 | heart left ventricle weight to body weight ratio | SD | male | 1.56 | mg/g | sham surgical control condition (for 28 days) | 101096 | sham surgical control condition (for 28 days) | | | | | | | |

9 | right kidney wet weight | SHR-Chr 8MWF/Rkb | male | 1.16 | g | sham surgical control condition (for 126 days) | 109554 | sham surgical control condition (for 126 days) | | | | | | | |

9 | right kidney wet weight | SHR/FubRkb | male | 1.07 | g | sham surgical control condition (for 126 days) | 109553 | sham surgical control condition (for 126 days) | | | | | | | |

12 | right kidney wet weight | WKY | male | 1.378 | g | sham surgical control condition (for 196 days) | 100371 | sham surgical control condition (for 196 days) | | | | | | | |

12 | right kidney wet weight | WKY | male | 1.378 | g | sham surgical control condition (for 196 days) | 100357 | sham surgical control condition (for 196 days) | | | | | | | |

6 | systolic blood pressure | SD | male | 118 | mmHg | sham surgical control condition (for 28 days) | 101583 | sham surgical control condition (for 28 days) | | | | | | | |

6 | systolic blood pressure | SD | male | 118 | mmHg | sham surgical control condition (between 12 and 14 days) | 101547 | sham surgical control condition (between 12 and 14 days) | | | | | | | |

6 | systolic blood pressure | SD | male | 144 | mmHg | sham surgical control condition (for 140 days) | 101090 | sham surgical control condition (for 140 days) | | | | | | | |

6 | systolic blood pressure | SD | male | 134 | mmHg | sham surgical control condition (for 28 days) | 101088 | sham surgical control condition (for 28 days) | | | | | | | |

5 | systolic blood pressure | WKY | male | 97.8 | mmHg | sham surgical control condition (for 224 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) | 100315 | sham surgical control condition (for 224 days) | | | ketamine (80 mg/kg) | | xylazine (10 mg/kg) | | |

5 | systolic blood pressure | MW | male | 165 | mmHg | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101365 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

6 | systolic blood pressure | MW | male | 130 | mmHg | losartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101363 | losartan (10 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | systolic blood pressure | MW | male | 160 | mmHg | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101361 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | systolic blood pressure | MW | male | 143 | mmHg | losartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101359 | losartan (10 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | systolic blood pressure | MW | male | 150 | mmHg | vehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101357 | vehicle control condition (0 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

5 | systolic blood pressure | MW | male | 151 | mmHg | losartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101355 | losartan (10 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

5 | systolic blood pressure | MW | male | 130 | mmHg | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101351 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | systolic blood pressure | MW | male | 129 | mmHg | ramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101349 | ramipril (3 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | systolic blood pressure | MW | male | 123 | mmHg | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101347 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

5 | systolic blood pressure | MW | male | 106 | mmHg | ramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101345 | ramipril (3 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

8 | both kidneys wet weight to body weight ratio | SBH/Ygl | male | 2.6 | g/kg | sham surgical control condition (for 56 days) and water (for 56 days) and standard rat chow (for 56 days) | 106649 | sham surgical control condition (for 56 days) | water (for 56 days) | standard rat chow (for 56 days) | | | | | |

8 | both kidneys wet weight to body weight ratio | SBN/Ygl | male | 2.4 | g/kg | sham surgical control condition (for 56 days) and water (for 56 days) and standard rat chow (for 56 days) | 106646 | sham surgical control condition (for 56 days) | water (for 56 days) | standard rat chow (for 56 days) | | | | | |

6 | plasma creatinine level | WKY | male | 0.41 | mg/dl | sham surgical control condition (for 196 days) | 100377 | sham surgical control condition (for 196 days) | | | | | | | |

6 | plasma creatinine level | WKY | male | 0.41 | mg/dl | sham surgical control condition (for 196 days) | 100363 | sham surgical control condition (for 196 days) | | | | | | | |

10 | urine albumin excretion rate | SHR-Chr 6MWF/Rkb | male | 0.5 | mg/d | sham surgical control condition | 108127 | sham surgical control condition | | | | | | | |

10 | urine albumin excretion rate | SHR-Chr 6MWF/Rkb | male | 1.3 | mg/d | sham surgical control condition | 108126 | sham surgical control condition | | | | | | | |

10 | urine albumin excretion rate | SHR/FubRkb | male | 0.4 | mg/d | sham surgical control condition | 108125 | sham surgical control condition | | | | | | | |

10 | urine albumin excretion rate | MWF/FubRkb | male | 108.7 | mg/d | sham surgical control condition | 108124 | sham surgical control condition | | | | | | | |

10 | urine albumin excretion rate | MWF/FubRkb | male | 22.8 | mg/d | sham surgical control condition | 108123 | sham surgical control condition | | | | | | | |

9 | urine albumin excretion rate | SHR-Chr 8MWF/Rkb | male | 1.3 | mg/d | sham surgical control condition (for 42 days) | 109564 | sham surgical control condition (for 42 days) | | | | | | | |

9 | urine albumin excretion rate | SHR-Chr 8MWF/Rkb | male | 10.8 | mg/d | sham surgical control condition (for 126 days) | 109563 | sham surgical control condition (for 126 days) | | | | | | | |

9 | urine albumin excretion rate | SHR/FubRkb | male | 0.4 | mg/d | sham surgical control condition (for 42 days) | 109562 | sham surgical control condition (for 42 days) | | | | | | | |

9 | urine albumin excretion rate | SHR/FubRkb | male | 1.3 | mg/d | sham surgical control condition (for 42 days) | 109561 | sham surgical control condition (for 42 days) | | | | | | | |

6 | plasma total cholesterol level | GK | female | 2.53 | mg/dl | sham surgical control condition (for 24 days) | 103767 | sham surgical control condition (for 24 days) | | | | | | | |

6 | plasma total cholesterol level | Crl:WI(Han) | female | 2.49 | mg/dl | sham surgical control condition (for 24 days) | 103765 | sham surgical control condition (for 24 days) | | | | | | | |

5 | diastolic blood pressure | WKY | male | 63.3 | mmHg | sham surgical control condition (for 224 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) | 100318 | sham surgical control condition (for 224 days) | | | ketamine (80 mg/kg) | | xylazine (10 mg/kg) | | |

5 | serum sodium level | WKY | male | 157.7 | mmol/l | sham surgical control condition (for 224 days) | 100330 | sham surgical control condition (for 224 days) | | | | | | | |

5 | serum potassium level | WKY | male | 5.3 | mmol/l | sham surgical control condition (for 224 days) | 100333 | sham surgical control condition (for 224 days) | | | | | | | |

5 | heart rate | WKY | male | 398 | beats/min | sham surgical control condition (for 224 days) | 100312 | sham surgical control condition (for 224 days) | | | | | | | |

5 | heart rate | MW | male | 382 | beats/min | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101388 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

6 | heart rate | MW | male | 407 | beats/min | losartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101385 | losartan (10 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart rate | MW | male | 366 | beats/min | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101383 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | heart rate | MW | male | 410 | beats/min | losartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101381 | losartan (10 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | heart rate | MW | male | 377 | beats/min | vehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101379 | vehicle control condition (0 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

5 | heart rate | MW | male | 424 | beats/min | losartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101377 | losartan (10 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

5 | heart rate | MW | male | 358 | beats/min | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101373 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart rate | MW | male | 402 | beats/min | ramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101371 | ramipril (3 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart rate | MW | male | 406 | beats/min | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101369 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

5 | heart rate | MW | male | 366 | beats/min | ramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101367 | ramipril (3 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

7 | heart rate | SD | male | 312 | beats/min | sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days) | 99297 | sham surgical control condition (for 28 days) | | | Aprotinin (12000 kIU) (for 28 days) | | | | |

7 | heart rate | SD | male | 321 | beats/min | sham surgical control condition (for 28 days) | 99295 | sham surgical control condition (for 28 days) | | | | | | | |

5 | heart rate | SD | male | 371 | beats/min | sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days) | 99293 | sham surgical control condition (for 2 days) | | | Aprotinin (12000 kIU) (for 2 days) | | | | |

5 | heart rate | SD | male | 359 | beats/min | sham surgical control condition (for 2 days) | 99291 | sham surgical control condition (for 2 days) | | | | | | | |

10 | heart rate | SD | male | 217 | beats/min | sham surgical control condition (for 105 days) | 99217 | sham surgical control condition (for 105 days) | | | | | | | |

8 | heart rate | SD | male | 260 | beats/min | sham surgical control condition (for 28 days) | 99215 | sham surgical control condition (for 28 days) | | | | | | | |

6 | heart rate | SD | male | 365 | beats/min | sham surgical control condition (for 2 days) then metoprolol succinate (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98805 | sham surgical control condition (for 2 days) | | | metoprolol succinate (100 mg/kg/d) (for 2 days) | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | |

6 | heart rate | SD | male | 380 | beats/min | sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98802 | sham surgical control condition (for 2 days) | | | vehicle control condition (for 2 days) | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | |

6 | heart rate | SD | male | 365 | beats/min | sham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98800 | sham surgical control condition (between 120 and 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

6 | heart rate | SD | male | 389 | beats/min | sham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98798 | sham surgical control condition (for 2 days) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | | | |

6 | heart rate | SD | male | 395 | beats/min | sham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98796 | sham surgical control condition (for 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

6 | heart rate | SD | male | 385 | beats/min | sham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98794 | sham surgical control condition (for 6 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

6 | heart wet weight | SD | male | 1.03 | g | sham surgical control condition (for 28 days) | 101587 | sham surgical control condition (for 28 days) | | | | | | | |

6 | left kidney wet weight | SD | male | 1.19 | g | sham surgical control condition (for 28 days) | 101579 | sham surgical control condition (for 28 days) | | | | | | | |

6 | left kidney wet weight | SD | male | 1.11 | g | sham surgical control condition (between 12 and 14 days) | 101543 | sham surgical control condition (between 12 and 14 days) | | | | | | | |

6 | both kidneys wet weight | SR/JrHsd | female | 1.57 | g | controlled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days) | 102349 | controlled sodium content diet (0.1 %) (for 112 days) | | | sham surgical control condition (between 56 and 63 days) | | | | |

6 | both kidneys wet weight | SS/JrHsd | female | 1.77 | g | controlled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days) | 102346 | controlled sodium content diet (0.1 %) (for 112 days) | | | sham surgical control condition (between 56 and 63 days) | | | | |

6 | plasma potassium level | SD | male | 5 | mmol/l | sham surgical control condition (for 28 days) | 101595 | sham surgical control condition (for 28 days) | | | | | | | |

10 | heart left ventricle weight to body weight ratio | SD | male | 1.9 | mg/g | sham surgical control condition (for 105 days) | 99205 | sham surgical control condition (for 105 days) | | | | | | | |

8 | heart left ventricle weight to body weight ratio | SD | male | 2.1 | mg/g | sham surgical control condition (for 28 days) | 99203 | sham surgical control condition (for 28 days) | | | | | | | |

6 | heart left ventricle weight to body weight ratio | SD | male | 2.5 | mg/g | sham surgical control condition (for 2 days) then metoprolol succinate (100 mg/kg/d) (for 2 days) | 98877 | sham surgical control condition (for 2 days) | | | metoprolol succinate (100 mg/kg/d) (for 2 days) | | | | |

6 | heart left ventricle weight to body weight ratio | SD | male | 2.3 | mg/g | sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) | 98875 | sham surgical control condition (for 2 days) | | | vehicle control condition (for 2 days) | | | | |

6 | heart left ventricle weight to body weight ratio | SD | male | 2.3 | mg/g | sham surgical control condition (between 120 and 12 hours) | 98792 | sham surgical control condition (between 120 and 12 hours) | | | | | | | |

6 | heart left ventricle weight to body weight ratio | SD | male | 2.2 | mg/g | sham surgical control condition (for 2 days) | 98790 | sham surgical control condition (for 2 days) | | | | | | | |

6 | heart left ventricle weight to body weight ratio | SD | male | 2.3 | mg/g | sham surgical control condition (for 12 hours) | 98788 | sham surgical control condition (for 12 hours) | | | | | | | |

6 | heart left ventricle weight to body weight ratio | SD | male | 2.2 | mg/g | sham surgical control condition (for 6 hours) | 98786 | sham surgical control condition (for 6 hours) | | | | | | | |

6 | plasma renin activity level | SD | male | 3.1 | ng/ml/h | sham surgical control condition (between 12 and 14 days) | 101563 | sham surgical control condition (between 12 and 14 days) | | | | | | | |

7 | plasma renin activity level | MW | male | 9.1 | ng/ml/h | sham surgical control condition (for 28 days) | 101043 | sham surgical control condition (for 28 days) | | | | | | | |

12 | heart left ventricle fractional shortening | WKY | male | 41.1 | % | sham surgical control condition (for 196 days) | 100348 | sham surgical control condition (for 196 days) | | | | | | | |

5 | heart left ventricle fractional shortening | WKY | male | 51.5 | % | sham surgical control condition (for 224 days) | 100303 | sham surgical control condition (for 224 days) | | | | | | | |

7 | heart left ventricle fractional shortening | SD | male | 38 | % | sham surgical control condition (for 28 days) | 99367 | sham surgical control condition (for 28 days) | | | | | | | |

5 | heart left ventricle fractional shortening | SD | male | 43 | % | sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days) | 99365 | sham surgical control condition (for 2 days) | | | Aprotinin (12000 kIU) (for 2 days) | | | | |

5 | heart left ventricle fractional shortening | SD | male | 41 | % | sham surgical control condition (for 2 days) | 99363 | sham surgical control condition (for 2 days) | | | | | | | |

10 | heart left ventricle fractional shortening | SD | male | 40 | % | sham surgical control condition (for 105 days) | 99257 | sham surgical control condition (for 105 days) | | | | | | | |

8 | heart left ventricle fractional shortening | SD | male | 38 | % | sham surgical control condition (for 28 days) | 99255 | sham surgical control condition (for 28 days) | | | | | | | |

5 | tibia length | WKY | male | 4.3 | cm | sham surgical control condition (for 224 days) | 100285 | sham surgical control condition (for 224 days) | | | | | | | |

6 | plasma low density lipoprotein cholesterol level | GK | female | 0.23 | mg/dl | sham surgical control condition (for 24 days) | 103771 | sham surgical control condition (for 24 days) | | | | | | | |

6 | plasma low density lipoprotein cholesterol level | Crl:WI(Han) | female | 0.21 | mg/dl | sham surgical control condition (for 24 days) | 103769 | sham surgical control condition (for 24 days) | | | | | | | |

8 | pituitary gland wet weight | COP/CrCrl | male | 0.0095 | g | sham surgical control condition | 69106 | sham surgical control condition | | | | | | | |

7 | pituitary gland wet weight | ACI/SegHsd | male | 0.0081 | g | sham surgical control condition | 69104 | sham surgical control condition | | | | | | | |

6 | pituitary gland wet weight | COP/CrCrl | male | 0.0076 | g | sham surgical control condition | 69102 | sham surgical control condition | | | | | | | |

6 | pituitary gland wet weight | ACI/SegHsd | male | 0.0077 | g | sham surgical control condition | 69100 | sham surgical control condition | | | | | | | |

10 | pituitary gland wet weight | BN/SsNHsd | female | 0.0075 | g | sham surgical control condition (between 193 and 199 days) | 13099 | sham surgical control condition (between 193 and 199 days) | | | | | | | |

10 | pituitary gland wet weight | ACI/SegHsd | female | 0.0089 | g | sham surgical control condition (between 193 and 199 days) | 13090 | sham surgical control condition (between 193 and 199 days) | | | | | | | |

6 | plasma aldosterone level | SD | male | 50 | pg/ml | sham surgical control condition (between 12 and 14 days) | 101555 | sham surgical control condition (between 12 and 14 days) | | | | | | | |

7 | heart left ventricular end-diastolic diameter | SD | male | 7.6 | mm | sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days) | 99345 | sham surgical control condition (for 28 days) | | | Aprotinin (12000 kIU) (for 28 days) | | | | |

7 | heart left ventricular end-diastolic diameter | SD | male | 7.7 | mm | sham surgical control condition (for 28 days) | 99343 | sham surgical control condition (for 28 days) | | | | | | | |

5 | heart left ventricular end-diastolic diameter | SD | male | 7 | mm | sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days) | 99341 | sham surgical control condition (for 2 days) | | | Aprotinin (12000 kIU) (for 2 days) | | | | |

5 | heart left ventricular end-diastolic diameter | SD | male | 6.9 | mm | sham surgical control condition (for 2 days) | 99339 | sham surgical control condition (for 2 days) | | | | | | | |

10 | heart left ventricular end-diastolic diameter | SD | male | 9 | mm | sham surgical control condition (for 105 days) | 99237 | sham surgical control condition (for 105 days) | | | | | | | |

8 | heart left ventricular end-diastolic diameter | SD | male | 7 | mm | sham surgical control condition (for 28 days) | 99235 | sham surgical control condition (for 28 days) | | | | | | | |

6 | heart left ventricular end-diastolic diameter | SD | male | 7.1 | mm | sham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98849 | sham surgical control condition (between 120 and 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

6 | heart left ventricular end-diastolic diameter | SD | male | 7.1 | mm | sham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98847 | sham surgical control condition (for 2 days) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | | | |

6 | heart left ventricular end-diastolic diameter | SD | male | 7.3 | mm | sham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98845 | sham surgical control condition (for 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | | | |

6 | heart left ventricular end-diastolic diameter | SD | male | 7.2 | mm | sham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98843 | sham surgical control condition (for 6 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

7 | heart left ventricle end-systolic diameter | SD | male | 4.7 | mm | sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days) | 99353 | sham surgical control condition (for 28 days) | | | Aprotinin (12000 kIU) (for 28 days) | | | | |

7 | heart left ventricle end-systolic diameter | SD | male | 4.7 | mm | sham surgical control condition (for 28 days) | 99351 | sham surgical control condition (for 28 days) | | | | | | | |

5 | heart left ventricle end-systolic diameter | SD | male | 4.1 | mm | sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days) | 99349 | sham surgical control condition (for 2 days) | | | Aprotinin (12000 kIU) (for 2 days) | | | | |

5 | heart left ventricle end-systolic diameter | SD | male | 4 | mm | sham surgical control condition (for 2 days) | 99347 | sham surgical control condition (for 2 days) | | | | | | | |

10 | heart left ventricle end-systolic diameter | SD | male | 5.6 | mm | sham surgical control condition (for 105 days) | 99241 | sham surgical control condition (for 105 days) | | | | | | | |

8 | heart left ventricle end-systolic diameter | SD | male | 4.3 | mm | sham surgical control condition (for 28 days) | 99239 | sham surgical control condition (for 28 days) | | | | | | | |

6 | heart left ventricle end-systolic diameter | SD | male | 3.9 | mm | sham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98857 | sham surgical control condition (between 120 and 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

6 | heart left ventricle end-systolic diameter | SD | male | 4 | mm | sham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98855 | sham surgical control condition (for 2 days) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | | | |

6 | heart left ventricle end-systolic diameter | SD | male | 3.8 | mm | sham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98853 | sham surgical control condition (for 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | | | |

6 | heart left ventricle end-systolic diameter | SD | male | 4.2 | mm | sham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98851 | sham surgical control condition (for 6 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

8 | plasma epinephrine level | SD | male | 75 | pg/ml | sham surgical control condition (for 105 days) | 99289 | sham surgical control condition (for 105 days) | | | | | | | |

8 | plasma epinephrine level | SD | male | 83 | pg/ml | sham surgical control condition (for 28 days) | 99287 | sham surgical control condition (for 28 days) | | | | | | | |

8 | plasma norepinephrine level | SD | male | 102 | pg/ml | sham surgical control condition (for 105 days) | 99285 | sham surgical control condition (for 105 days) | | | | | | | |

8 | plasma norepinephrine level | SD | male | 93 | pg/ml | sham surgical control condition (for 28 days) | 99283 | sham surgical control condition (for 28 days) | | | | | | | |

6 | plasma insulin level | GK | female | 26 | mU/l | sham surgical control condition (for 24 days) | 103763 | sham surgical control condition (for 24 days) | | | | | | | |

6 | plasma insulin level | Crl:WI(Han) | female | 221 | mU/l | sham surgical control condition (for 24 days) | 103761 | sham surgical control condition (for 24 days) | | | | | | | |

9 | body weight | SHR-Chr 8MWF/Rkb | male | 345 | g | sham surgical control condition (for 126 days) | 109551 | sham surgical control condition (for 126 days) | | | | | | | |

9 | body weight | SHR/FubRkb | male | 329.2 | g | sham surgical control condition (for 126 days) | 109549 | sham surgical control condition (for 126 days) | | | | | | | |

8 | body weight | SBH/Ygl | male | 359 | g | sham surgical control condition (for 56 days) and water (for 56 days) and standard rat chow (for 56 days) | 106643 | sham surgical control condition (for 56 days) | water (for 56 days) | standard rat chow (for 56 days) | | | | | |

8 | body weight | SBN/Ygl | male | 328 | g | sham surgical control condition (for 56 days) and water (for 56 days) and standard rat chow (for 56 days) | 106640 | sham surgical control condition (for 56 days) | water (for 56 days) | standard rat chow (for 56 days) | | | | | |

6 | body weight | SR/JrHsd | female | 253.5 | g | controlled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days) | 102343 | controlled sodium content diet (0.1 %) (for 112 days) | | | sham surgical control condition (between 56 and 63 days) | | | | |

6 | body weight | SS/JrHsd | female | 281.5 | g | controlled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days) | 102340 | controlled sodium content diet (0.1 %) (for 112 days) | | | sham surgical control condition (between 56 and 63 days) | | | | |

6 | body weight | SD | male | 347 | g | sham surgical control condition (for 28 days) | 101571 | sham surgical control condition (for 28 days) | | | | | | | |

6 | body weight | SD | male | 336 | g | sham surgical control condition (between 12 and 14 days) | 101535 | sham surgical control condition (between 12 and 14 days) | | | | | | | |

6 | body weight | SD | male | 532.2 | g | sham surgical control condition (for 140 days) | 101078 | sham surgical control condition (for 140 days) | | | | | | | |

6 | body weight | SD | male | 378.1 | g | sham surgical control condition (for 28 days) | 101076 | sham surgical control condition (for 28 days) | | | | | | | |

5 | body weight | WKY | male | 562 | g | sham surgical control condition (for 224 days) | 100273 | sham surgical control condition (for 224 days) | | | | | | | |

12 | body weight | WKY | male | 566 | g | sham surgical control condition (for 196 days) | 100270 | sham surgical control condition (for 196 days) | | | | | | | |

12 | body weight | WKY | male | 223 | g | sham surgical control condition | 100267 | sham surgical control condition | | | | | | | |

N/A | body weight | SS/JrHsd | female | 235 | g | controlled sodium chloride content diet (4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) | 102190 | controlled sodium chloride content diet (4 %) (for 14 days) | | | sham surgical control condition | | peanut oil (0.2 ml) (for 14 days) | | |

N/A | body weight | SS/JrHsd | female | 252 | g | controlled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) | 102189 | controlled sodium chloride content diet (0.4 %) (for 14 days) | | | sham surgical control condition | | peanut oil (0.2 ml) (for 14 days) | | |

N/A | body weight | SR/JrHsd | female | 232 | g | controlled sodium chloride content diet (4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) | 102184 | controlled sodium chloride content diet (4 %) (for 14 days) | | | sham surgical control condition | | peanut oil (0.2 ml) (for 14 days) | | |

N/A | body weight | SR/JrHsd | female | 226 | g | controlled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) | 102183 | controlled sodium chloride content diet (0.4 %) (for 14 days) | | | sham surgical control condition | | peanut oil (0.2 ml) (for 14 days) | | |

6 | body weight | MW | male | 201 | g | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101321 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

6 | body weight | MW | male | 204 | g | losartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101319 | losartan (10 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | body weight | MW | male | 192 | g | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101317 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | body weight | MW | male | 184 | g | losartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101315 | losartan (10 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | body weight | MW | male | 200 | g | vehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101313 | vehicle control condition (0 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

6 | body weight | MW | male | 190 | g | losartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101311 | losartan (10 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

5 | body weight | MW | male | 180 | g | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101307 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | body weight | MW | male | 186 | g | ramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101305 | ramipril (3 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | body weight | MW | male | 188 | g | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101303 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

5 | body weight | MW | male | 193 | g | ramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101301 | ramipril (3 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

10 | body weight | SD | male | 471 | g | sham surgical control condition (for 105 days) | 99193 | sham surgical control condition (for 105 days) | | | | | | | |

8 | body weight | SD | male | 359 | g | sham surgical control condition (for 28 days) | 99191 | sham surgical control condition (for 28 days) | | | | | | | |

6 | body weight | GK | female | 229 | g | sham surgical control condition (for 24 days) | 103755 | sham surgical control condition (for 24 days) | | | | | | | |

6 | body weight | Crl:WI(Han) | female | 292 | g | sham surgical control condition (for 24 days) | 102930 | sham surgical control condition (for 24 days) | | | | | | | |

14 | body weight | Crl:WI(WU) | male | 334 | g | sham surgical control condition | 100005 | sham surgical control condition | | | | | | | |

6 | body weight | SD | male | 284 | g | sham surgical control condition (between 120 and 12 hours) | 98776 | sham surgical control condition (between 120 and 12 hours) | | | | | | | |

6 | body weight | SD | male | 282 | g | sham surgical control condition (for 2 days) | 98774 | sham surgical control condition (for 2 days) | | | | | | | |

6 | body weight | SD | male | 271 | g | sham surgical control condition (for 12 hours) | 98772 | sham surgical control condition (for 12 hours) | | | | | | | |

6 | body weight | SD | male | 291 | g | sham surgical control condition (for 6 hours) | 98756 | sham surgical control condition (for 6 hours) | | | | | | | |

5 | left ventricular end-systolic blood pressure | WKY | male | 93 | mmHg | sham surgical control condition (for 224 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) | 100321 | sham surgical control condition (for 224 days) | | | ketamine (80 mg/kg) | | xylazine (10 mg/kg) | | |

7 | left ventricular end-systolic blood pressure | SD | male | 86 | mmHg | sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days) | 99321 | sham surgical control condition (for 28 days) | | | Aprotinin (12000 kIU) (for 28 days) | | | | |

7 | left ventricular end-systolic blood pressure | SD | male | 85 | mmHg | sham surgical control condition (for 28 days) | 99319 | sham surgical control condition (for 28 days) | | | | | | | |

5 | left ventricular end-systolic blood pressure | SD | male | 58 | mmHg | sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days) | 99317 | sham surgical control condition (for 2 days) | | | Aprotinin (12000 kIU) (for 2 days) | | | | |

5 | left ventricular end-systolic blood pressure | SD | male | 55 | mmHg | sham surgical control condition (for 2 days) | 99315 | sham surgical control condition (for 2 days) | | | | | | | |

6 | left ventricular end-systolic blood pressure | SD | male | 64 | mmHg | sham surgical control condition (for 2 days) then metoprolol (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98841 | sham surgical control condition (for 2 days) | | | metoprolol (100 mg/kg/d) (for 2 days) | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | |

6 | left ventricular end-systolic blood pressure | SD | male | 64 | mmHg | sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98839 | sham surgical control condition (for 2 days) | | | vehicle control condition (for 2 days) | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | |

6 | left ventricular end-systolic blood pressure | SD | male | 58 | mmHg | sham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98837 | sham surgical control condition (between 120 and 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

6 | left ventricular end-systolic blood pressure | SD | male | 66 | mmHg | sham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98835 | sham surgical control condition (for 2 days) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | | | |

6 | left ventricular end-systolic blood pressure | SD | male | 62 | mmHg | sham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98833 | sham surgical control condition (for 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | | | |

6 | left ventricular end-systolic blood pressure | SD | male | 58 | mmHg | sham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98831 | sham surgical control condition (for 6 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

5 | left ventricular end-systolic blood pressure | WKY.WKHA-(D5Rat45-D5Rat245)/Cfd | female | 120.3 | mmHg | sham surgical control condition | 68872 | sham surgical control condition | | | | | | | |

5 | left ventricular end-systolic blood pressure | WKHA/Cfd | female | 131 | mmHg | sham surgical control condition | 68869 | sham surgical control condition | | | | | | | |

5 | left ventricular end-systolic blood pressure | WKY/Cfd | female | 129.7 | mmHg | sham surgical control condition | 68867 | sham surgical control condition | | | | | | | |

5 | left ventricular end-systolic blood pressure | WKY.WKHA-(D5Rat45-D5Rat245)/Cfd | male | 139.9 | mmHg | sham surgical control condition | 68865 | sham surgical control condition | | | | | | | |

5 | left ventricular end-systolic blood pressure | WKHA/Cfd | male | 126 | mmHg | sham surgical control condition | 68863 | sham surgical control condition | | | | | | | |

5 | left ventricular end-systolic blood pressure | WKY/Cfd | male | 125.3 | mmHg | sham surgical control condition | 68861 | sham surgical control condition | | | | | | | |

6 | kidney sclerotic glomeruli count to total glomeruli count ratio | SD | male | 1.9 | % | sham surgical control condition (for 28 days) | 101603 | sham surgical control condition (for 28 days) | | | | | | | |

6 | urine protein excretion rate | SD | male | 19 | mg/d | sham surgical control condition (for 28 days) | 101591 | sham surgical control condition (for 28 days) | | | | | | | |

6 | urine protein excretion rate | SD | male | 10 | mg/d | sham surgical control condition (between 12 and 14 days) | 101551 | sham surgical control condition (between 12 and 14 days) | | | | | | | |

12 | heart ventricle septal wall thickness | WKY | male | 0.14 | cm | sham surgical control condition (for 196 days) | 100336 | sham surgical control condition (for 196 days) | | | | | | | |

5 | heart weight to tibia length ratio | WKY | male | 0.278 | g/cm | sham surgical control condition (for 224 days) | 100282 | sham surgical control condition (for 224 days) | | | | | | | |

6 | change in body weight | SD | male | 99 | g | sham surgical control condition (for 28 days) | 101575 | sham surgical control condition (for 28 days) | | | | | | | |

6 | change in body weight | SD | male | 84 | g | sham surgical control condition (between 12 and 14 days) | 101539 | sham surgical control condition (between 12 and 14 days) | | | | | | | |

7 | timed urine volume | WKY | male | 13.9 | ml/d | sham surgical control condition (for 196 days) | 100374 | sham surgical control condition (for 196 days) | | | | | | | |

7 | timed urine volume | WKY | male | 13.9 | ml/d | sham surgical control condition (for 196 days) | 100360 | sham surgical control condition (for 196 days) | | | | | | | |

12 | heart left ventricle end-systolic diameter | WKY | male | 4.9 | mm | sham surgical control condition (for 196 days) | 100342 | sham surgical control condition (for 196 days) | | | | | | | |

5 | heart left ventricle end-systolic diameter | WKY | male | 3.8 | mm | sham surgical control condition (for 224 days) | 100309 | sham surgical control condition (for 224 days) | | | | | | | |

11 | kidney fibrotic lesion area to total kidney area ratio | WKY | male | 0.91 | % | sham surgical control condition (for 196 days) | 100383 | sham surgical control condition (for 196 days) | | | | | | | |

12 | heart left ventricular end-diastolic diameter | WKY | male | 8.3 | mm | sham surgical control condition (for 196 days) | 100339 | sham surgical control condition (for 196 days) | | | | | | | |

5 | heart left ventricular end-diastolic diameter | WKY | male | 7.9 | mm | sham surgical control condition (for 224 days) | 100306 | sham surgical control condition (for 224 days) | | | | | | | |

5 | time constant of left ventricular pressure decay | WKY.WKHA-(D5Rat45-D5Rat245)/Cfd | female | 7.5 | ms | sham surgical control condition | 68924 | sham surgical control condition | | | | | | | |

5 | time constant of left ventricular pressure decay | WKHA/Cfd | female | 13.5 | ms | sham surgical control condition | 68922 | sham surgical control condition | | | | | | | |

5 | time constant of left ventricular pressure decay | WKY/Cfd | female | 11.1 | ms | sham surgical control condition | 68920 | sham surgical control condition | | | | | | | |

5 | time constant of left ventricular pressure decay | WKY.WKHA-(D5Rat45-D5Rat245)/Cfd | male | 7.5 | ms | sham surgical control condition | 68918 | sham surgical control condition | | | | | | | |

5 | time constant of left ventricular pressure decay | WKHA/Cfd | male | 13.3 | ms | sham surgical control condition | 68916 | sham surgical control condition | | | | | | | |

5 | time constant of left ventricular pressure decay | WKY/Cfd | male | 18.6 | ms | sham surgical control condition | 68914 | sham surgical control condition | | | | | | | |

5 | maximum rate of positive change in left ventricular blood pressure | WKY | male | 4225 | mmHg/s | sham surgical control condition (for 224 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) | 100327 | sham surgical control condition (for 224 days) | | | ketamine (80 mg/kg) | | xylazine (10 mg/kg) | | |

7 | maximum rate of positive change in left ventricular blood pressure | SD | male | 7931 | mmHg/s | sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days) | 99329 | sham surgical control condition (for 28 days) | | | Aprotinin (12000 kIU) (for 28 days) | | | | |

7 | maximum rate of positive change in left ventricular blood pressure | SD | male | 8505 | mmHg/s | sham surgical control condition (for 28 days) | 99327 | sham surgical control condition (for 28 days) | | | | | | | |

5 | maximum rate of positive change in left ventricular blood pressure | SD | male | 8301 | mmHg/s | sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days) | 99325 | sham surgical control condition (for 2 days) | | | Aprotinin (12000 kIU) (for 2 days) | | | | |

5 | maximum rate of positive change in left ventricular blood pressure | SD | male | 8767 | mmHg/s | sham surgical control condition (for 2 days) | 99323 | sham surgical control condition (for 2 days) | | | | | | | |

10 | maximum rate of positive change in left ventricular blood pressure | SD | male | 7529 | mmHg/s | sham surgical control condition (for 105 days) | 99229 | sham surgical control condition (for 105 days) | | | | | | | |

8 | maximum rate of positive change in left ventricular blood pressure | SD | male | 8031 | mmHg/s | sham surgical control condition (for 28 days) | 99227 | sham surgical control condition (for 28 days) | | | | | | | |

6 | maximum rate of positive change in left ventricular blood pressure | SD | male | 7985 | mmHg/s | sham surgical control condition (for 2 days) then metoprolol (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98889 | sham surgical control condition (for 2 days) | | | metoprolol (100 mg/kg/d) (for 2 days) | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | |

6 | maximum rate of positive change in left ventricular blood pressure | SD | male | 8231 | mmHg/s | sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98887 | sham surgical control condition (for 2 days) | | | vehicle control condition (for 2 days) | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | |

5 | maximum rate of positive change in left ventricular blood pressure | WKY.WKHA-(D5Rat45-D5Rat245)/Cfd | female | 9210 | mmHg/s | sham surgical control condition | 68900 | sham surgical control condition | | | | | | | |

5 | maximum rate of positive change in left ventricular blood pressure | WKHA/Cfd | female | 10484 | mmHg/s | sham surgical control condition | 68898 | sham surgical control condition | | | | | | | |

5 | maximum rate of positive change in left ventricular blood pressure | WKY/Cfd | female | 10672 | mmHg/s | sham surgical control condition | 68896 | sham surgical control condition | | | | | | | |

5 | maximum rate of positive change in left ventricular blood pressure | WKY.WKHA-(D5Rat45-D5Rat245)/Cfd | male | 10888 | mmHg/s | sham surgical control condition | 68894 | sham surgical control condition | | | | | | | |

5 | maximum rate of positive change in left ventricular blood pressure | WKHA/Cfd | male | 9127 | mmHg/s | sham surgical control condition | 68892 | sham surgical control condition | | | | | | | |

5 | maximum rate of positive change in left ventricular blood pressure | WKY/Cfd | male | 9876 | mmHg/s | sham surgical control condition | 68890 | sham surgical control condition | | | | | | | |

7 | maximum rate of negative change in left ventricular blood pressure | SD | male | -7422 | mmHg/s | sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days) | 99336 | sham surgical control condition (for 28 days) | | | Aprotinin (12000 kIU) (for 28 days) | | | | |

7 | maximum rate of negative change in left ventricular blood pressure | SD | male | -7379 | mmHg/s | sham surgical control condition (for 28 days) | 99335 | sham surgical control condition (for 28 days) | | | | | | | |

5 | maximum rate of negative change in left ventricular blood pressure | SD | male | -8474 | mmHg/s | sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days) | 99333 | sham surgical control condition (for 2 days) | | | Aprotinin (12000 kIU) (for 2 days) | | | | |

5 | maximum rate of negative change in left ventricular blood pressure | SD | male | -7474 | mmHg/s | sham surgical control condition (for 2 days) | 99331 | sham surgical control condition (for 2 days) | | | | | | | |

10 | maximum rate of negative change in left ventricular blood pressure | SD | male | -5401 | mmHg/s | sham surgical control condition (for 105 days) | 99233 | sham surgical control condition (for 105 days) | | | | | | | |

8 | maximum rate of negative change in left ventricular blood pressure | SD | male | -7479 | mmHg/s | sham surgical control condition (for 28 days) | 99231 | sham surgical control condition (for 28 days) | | | | | | | |

6 | maximum rate of negative change in left ventricular blood pressure | SD | male | -7212 | mmHg/s | sham surgical control condition (for 2 days) then metoprolol succinate (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98893 | sham surgical control condition (for 2 days) | | | metoprolol succinate (100 mg/kg/d) (for 2 days) | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | |

6 | maximum rate of negative change in left ventricular blood pressure | SD | male | -7197 | mmHg/s | sham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98891 | sham surgical control condition (for 2 days) | | | vehicle control condition (for 2 days) | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | |

5 | maximum rate of negative change in left ventricular blood pressure | WKY.WKHA-(D5Rat45-D5Rat245)/Cfd | female | 6589 | mmHg/s | sham surgical control condition | 68912 | sham surgical control condition | | | | | | | |

5 | maximum rate of negative change in left ventricular blood pressure | WKHA/Cfd | female | 6612 | mmHg/s | sham surgical control condition | 68910 | sham surgical control condition | | | | | | | |

5 | maximum rate of negative change in left ventricular blood pressure | WKY/Cfd | female | 7503 | mmHg/s | sham surgical control condition | 68908 | sham surgical control condition | | | | | | | |

5 | maximum rate of negative change in left ventricular blood pressure | WKY.WKHA-(D5Rat45-D5Rat245)/Cfd | male | 7570 | mmHg/s | sham surgical control condition | 68906 | sham surgical control condition | | | | | | | |

5 | maximum rate of negative change in left ventricular blood pressure | WKHA/Cfd | male | 5901 | mmHg/s | sham surgical control condition | 68904 | sham surgical control condition | | | | | | | |

5 | maximum rate of negative change in left ventricular blood pressure | WKY/Cfd | male | 6808 | mmHg/s | sham surgical control condition | 68902 | sham surgical control condition | | | | | | | |

10 | binary logarithm of pituitary gland wet weight | ACI/SegHsd | female | 3.13 | | sham surgical control condition (between 193 and 199 days) | 65771 | sham surgical control condition (between 193 and 199 days) | | | | | | | |

10 | binary logarithm of pituitary gland wet weight | BN/SsNHsd | female | 2.89 | | sham surgical control condition (between 193 and 199 days) | 65769 | sham surgical control condition (between 193 and 199 days) | | | | | | | |

6 | plasma sodium level | SS/Hsd | male | 138.9 | mmol/l | controlled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days) | 102255 | controlled sodium content diet (8 %) (for 21 days) | | | intracerebroventricular cannula implantation | | scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) | | sham surgical control condition (for 21 days) |

6 | plasma sodium level | SS/Hsd | male | 140.3 | mmol/l | controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days) | 102253 | controlled sodium content diet (0.4 %) (for 21 days) | | | intracerebroventricular cannula implantation | | scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) | | sham surgical control condition (for 21 days) |

6 | plasma sodium level | SR/Hsd | male | 139.8 | mmol/l | controlled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days) | 102251 | controlled sodium content diet (8 %) (for 21 days) | | | intracerebroventricular cannula implantation | | scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) | | sham surgical control condition (for 21 days) |

6 | plasma sodium level | SR/Hsd | male | 140.8 | mmol/l | controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days) | 102249 | controlled sodium content diet (0.4 %) (for 21 days) | | | intracerebroventricular cannula implantation | | scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) | | sham surgical control condition (for 21 days) |

12 | heart posterior wall thickness | WKY | male | 0.17 | cm | sham surgical control condition (for 196 days) | 100345 | sham surgical control condition (for 196 days) | | | | | | | |

11 | index of glomerular damage | WKY | male | 1.39 | | sham surgical control condition (for 196 days) | 100366 | sham surgical control condition (for 196 days) | | | | | | | |

6 | adrenal gland weight | SD | male | 46 | mg | sham surgical control condition (for 28 days) | 101599 | sham surgical control condition (for 28 days) | | | | | | | |

6 | adrenal gland weight | SD | male | 51 | mg | sham surgical control condition (between 12 and 14 days) | 101559 | sham surgical control condition (between 12 and 14 days) | | | | | | | |

N/A | single kidney wet weight | SS/JrHsd | female | 1.26 | g | controlled sodium chloride content diet (4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) | 102202 | controlled sodium chloride content diet (4 %) (for 14 days) | | | sham surgical control condition | | peanut oil (0.2 ml) (for 14 days) | | |

N/A | single kidney wet weight | SS/JrHsd | female | 0.87 | g | controlled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) | 102201 | controlled sodium chloride content diet (0.4 %) (for 14 days) | | | sham surgical control condition | | peanut oil (0.2 ml) (for 14 days) | | |

N/A | single kidney wet weight | SR/JrHsd | female | 1.05 | g | controlled sodium chloride content diet (4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) | 102196 | controlled sodium chloride content diet (4 %) (for 14 days) | | | sham surgical control condition | | peanut oil (0.2 ml) (for 14 days) | | |

N/A | single kidney wet weight | SR/JrHsd | female | 0.86 | g | controlled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) | 102195 | controlled sodium chloride content diet (0.4 %) (for 14 days) | | | sham surgical control condition | | peanut oil (0.2 ml) (for 14 days) | | |

6 | heart left ventricle end-diastolic posterior wall thickness | SD | male | 1.6 | mm | sham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98865 | sham surgical control condition (between 120 and 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

6 | heart left ventricle end-diastolic posterior wall thickness | SD | male | 1.6 | mm | sham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98863 | sham surgical control condition (for 2 days) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | | | |

6 | heart left ventricle end-diastolic posterior wall thickness | SD | male | 1.6 | mm | sham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98861 | sham surgical control condition (for 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | | | |

6 | heart left ventricle end-diastolic posterior wall thickness | SD | male | 1.6 | mm | sham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98859 | sham surgical control condition (for 6 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

5 | heart left ventricle weight to tibia length ratio | WKY | male | 0.194 | g/cm | sham surgical control condition (for 224 days) | 100294 | sham surgical control condition (for 224 days) | | | | | | | |

11 | artery tunica media width to artery inner diameter ratio | WKY | male | 1.89 | | sham surgical control condition (for 196 days) | 100386 | sham surgical control condition (for 196 days) | | | | | | | |

12 | E/A wave ratio | WKY | male | 1.39 | | sham surgical control condition (for 196 days) | 100354 | sham surgical control condition (for 196 days) | | | | | | | |

9 | plasma cystatin C level | SHR-Chr 8MWF/Rkb | male | 0.05 | mg/l | sham surgical control condition (for 126 days) | 109568 | sham surgical control condition (for 126 days) | | | | | | | |

9 | plasma cystatin C level | SHR/FubRkb | male | 0.05 | mg/l | sham surgical control condition (for 126 days) | 109566 | sham surgical control condition (for 126 days) | | | | | | | |

14 | plasma angiotensin I converting enzyme activity level | Crl:WI(WU) | male | 62.2 | nmol/min/mL | sham surgical control condition | 100029 | sham surgical control condition | | | | | | | |

6 | heart left ventricle weight | SD | male | 0.76 | g | sham surgical control condition (for 140 days) | 101094 | sham surgical control condition (for 140 days) | | | | | | | |

6 | heart left ventricle weight | SD | male | 0.6 | g | sham surgical control condition (for 28 days) | 101092 | sham surgical control condition (for 28 days) | | | | | | | |

5 | heart left ventricle weight | WKY | male | 0.84 | g | sham surgical control condition (for 224 days) | 100291 | sham surgical control condition (for 224 days) | | | | | | | |

12 | heart left ventricle weight | WKY | male | 0.847 | g | sham surgical control condition (for 196 days) | 100288 | sham surgical control condition (for 196 days) | | | | | | | |

6 | heart left ventricle weight | MW | male | 0.196 | g | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101409 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

6 | heart left ventricle weight | MW | male | 0.195 | g | losartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101407 | losartan (10 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart left ventricle weight | MW | male | 0.214 | g | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101405 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | heart left ventricle weight | MW | male | 0.206 | g | losartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101403 | losartan (10 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | heart left ventricle weight | MW | male | 0.211 | g | vehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101401 | vehicle control condition (0 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

6 | heart left ventricle weight | MW | male | 0.208 | g | losartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101399 | losartan (10 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

5 | heart left ventricle weight | MW | male | 0.214 | g | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101395 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart left ventricle weight | MW | male | 0.204 | g | ramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101393 | ramipril (3 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart left ventricle weight | MW | male | 0.22 | g | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101391 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

5 | heart left ventricle weight | MW | male | 0.194 | g | ramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101389 | ramipril (3 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

5 | heart left ventricle weight | MW | male | 0.061 | g | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101413 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | heart right ventricle weight | SD | male | 0.27 | g | sham surgical control condition (for 140 days) | 101102 | sham surgical control condition (for 140 days) | | | | | | | |

6 | heart right ventricle weight | SD | male | 0.23 | g | sham surgical control condition (for 28 days) | 101100 | sham surgical control condition (for 28 days) | | | | | | | |

6 | heart right ventricle weight | MW | male | 0.048 | g | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101431 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

6 | heart right ventricle weight | MW | male | 0.046 | g | losartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101429 | losartan (10 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart right ventricle weight | MW | male | 0.048 | g | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101427 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | heart right ventricle weight | MW | male | 0.053 | g | losartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101425 | losartan (10 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | heart right ventricle weight | MW | male | 0.054 | g | vehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101423 | vehicle control condition (0 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

6 | heart right ventricle weight | MW | male | 0.054 | g | losartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101421 | losartan (10 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

5 | heart right ventricle weight | MW | male | 0.061 | g | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101417 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart right ventricle weight | MW | male | 0.06 | g | ramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101415 | ramipril (3 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart right ventricle weight | MW | male | 0.059 | g | ramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101411 | ramipril (3 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | left atrium weight | SD | male | 0.04 | g | sham surgical control condition (for 140 days) | 101110 | sham surgical control condition (for 140 days) | | | | | | | |

6 | left atrium weight | SD | male | 0.03 | g | sham surgical control condition (for 28 days) | 101108 | sham surgical control condition (for 28 days) | | | | | | | |

6 | right atrium weight | SD | male | 0.04 | g | sham surgical control condition (for 140 days) | 101118 | sham surgical control condition (for 140 days) | | | | | | | |

6 | right atrium weight | SD | male | 0.04 | g | sham surgical control condition (for 28 days) | 101116 | sham surgical control condition (for 28 days) | | | | | | | |

10 | heart right ventricle weight to body weight ratio | SD | male | 0.5 | mg/g | sham surgical control condition (for 105 days) | 99209 | sham surgical control condition (for 105 days) | | | | | | | |

8 | heart right ventricle weight to body weight ratio | SD | male | 0.5 | mg/g | sham surgical control condition (for 28 days) | 99207 | sham surgical control condition (for 28 days) | | | | | | | |

10 | lung weight | SD | male | 1.97 | g | sham surgical control condition (for 105 days) | 99213 | sham surgical control condition (for 105 days) | | | | | | | |

8 | lung weight | SD | male | 1.46 | g | sham surgical control condition (for 28 days) | 99211 | sham surgical control condition (for 28 days) | | | | | | | |

8 | plasma angiotensin II level | SD | male | 34 | pg/ml | sham surgical control condition (for 105 days) | 99277 | sham surgical control condition (for 105 days) | | | | | | | |

8 | plasma angiotensin II level | SD | male | 29 | pg/ml | sham surgical control condition (for 28 days) | 99275 | sham surgical control condition (for 28 days) | | | | | | | |

6 | uterus weight | SR/JrHsd | female | 0.41 | g | controlled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days) | 102355 | controlled sodium content diet (0.1 %) (for 112 days) | | | sham surgical control condition (between 56 and 63 days) | | | | |

6 | uterus weight | SS/JrHsd | female | 0.44 | g | controlled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days) | 102352 | controlled sodium content diet (0.1 %) (for 112 days) | | | sham surgical control condition (between 56 and 63 days) | | | | |

6 | plasma estradiol level | SR/JrHsd | female | 17.1 | pg/ml | controlled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days) | 102361 | controlled sodium content diet (0.1 %) (for 112 days) | | | sham surgical control condition (between 56 and 63 days) | | | | |

6 | plasma estradiol level | SS/JrHsd | female | 15.7 | pg/ml | controlled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days) | 102358 | controlled sodium content diet (0.1 %) (for 112 days) | | | sham surgical control condition (between 56 and 63 days) | | | | |

6 | plasma estradiol level | GK | female | 49.6 | pg/ml | sham surgical control condition (for 24 days) | 103775 | sham surgical control condition (for 24 days) | | | | | | | |

6 | plasma estradiol level | Crl:WI(Han) | female | 48.6 | pg/ml | sham surgical control condition (for 24 days) | 103773 | sham surgical control condition (for 24 days) | | | | | | | |

6 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.32 | pmol/l | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101453 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

6 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.22 | pmol/l | losartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101451 | losartan (10 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.37 | pmol/l | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101449 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.25 | pmol/l | losartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101447 | losartan (10 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.23 | pmol/l | vehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101445 | vehicle control condition (0 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

6 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.2 | pmol/l | losartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101443 | losartan (10 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

5 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.39 | pmol/l | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101439 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.33 | pmol/l | ramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101437 | ramipril (3 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.26 | pmol/l | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101435 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

5 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.31 | pmol/l | ramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101433 | ramipril (3 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.65 | pmol/l | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101498 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

6 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.8 | pmol/l | losartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101496 | losartan (10 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.79 | pmol/l | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101494 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.93 | pmol/l | losartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101492 | losartan (10 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 1 | pmol/l | vehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101489 | vehicle control condition (0 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

6 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.79 | pmol/l | losartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101487 | losartan (10 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

5 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 1.24 | pmol/l | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101483 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.79 | pmol/l | ramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101481 | ramipril (3 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.85 | pmol/l | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101479 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

5 | heart insulin-like growth factor 1 receptor mRNA level | MW | male | 0.8 | pmol/l | ramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101477 | ramipril (3 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | heart insulin-like growth factor 1 mRNA level | MW | male | 0.34 | pmol/l | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101475 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

6 | heart insulin-like growth factor 1 mRNA level | MW | male | 0.58 | pmol/l | losartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101473 | losartan (10 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart insulin-like growth factor 1 mRNA level | MW | male | 0.58 | pmol/l | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101471 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | heart insulin-like growth factor 1 mRNA level | MW | male | 0.64 | pmol/l | losartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101469 | losartan (10 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

6 | heart insulin-like growth factor 1 mRNA level | MW | male | 0.4 | pmol/l | vehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101467 | vehicle control condition (0 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

6 | heart insulin-like growth factor 1 mRNA level | MW | male | 0.26 | pmol/l | losartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days) | 101465 | losartan (10 mg/kg/d) (for 3 days) | | | sham surgical control condition (for 2 days) | | | | |

5 | heart insulin-like growth factor 1 mRNA level | MW | male | 0.59 | pmol/l | vehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101461 | vehicle control condition (0 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart insulin-like growth factor 1 mRNA level | MW | male | 0.34 | pmol/l | ramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days) | 101459 | ramipril (3 mg/kg/d) (for 8 days) | | | sham surgical control condition (for 7 days) | | | | |

5 | heart insulin-like growth factor 1 mRNA level | MW | male | 0.43 | pmol/l | vehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101457 | vehicle control condition (0 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

5 | heart insulin-like growth factor 1 mRNA level | MW | male | 0.38 | pmol/l | ramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days) | 101455 | ramipril (3 mg/kg/d) (for 5 days) | | | sham surgical control condition (for 4 days) | | | | |

N/A | glomerular filtration rate to kidney weight ratio | SS/JrHsd | female | 2.46 | ml/min/g | controlled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) | 102216 | controlled sodium chloride content diet (0.4 %) (for 14 days) | | | sham surgical control condition | | peanut oil (0.2 ml) (for 14 days) | | |

N/A | glomerular filtration rate to kidney weight ratio | SR/JrHsd | female | 2.2 | ml/min/g | controlled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days) | 102213 | controlled sodium chloride content diet (0.4 %) (for 14 days) | | | sham surgical control condition | | peanut oil (0.2 ml) (for 14 days) | | |

7 | left ventricle end-diastolic wall stress | SD | male | 4 | g/cm2 | sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days) | 99393 | sham surgical control condition (for 28 days) | | | Aprotinin (12000 kIU) (for 28 days) | | | | |

7 | left ventricle end-diastolic wall stress | SD | male | 4 | g/cm2 | sham surgical control condition (for 28 days) | 99391 | sham surgical control condition (for 28 days) | | | | | | | |

5 | left ventricle end-diastolic wall stress | SD | male | 6 | g/cm2 | sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days) | 99389 | sham surgical control condition (for 2 days) | | | Aprotinin (12000 kIU) (for 2 days) | | | | |

5 | left ventricle end-diastolic wall stress | SD | male | 4 | g/cm2 | sham surgical control condition (for 2 days) | 99387 | sham surgical control condition (for 2 days) | | | | | | | |

10 | left ventricle end-diastolic wall stress | SD | male | 7 | g/cm2 | sham surgical control condition (for 105 days) | 99249 | sham surgical control condition (for 105 days) | | | | | | | |

8 | left ventricle end-diastolic wall stress | SD | male | 3 | g/cm2 | sham surgical control condition (for 28 days) | 99247 | sham surgical control condition (for 28 days) | | | | | | | |

7 | left ventricle end-systolic wall stress | SD | male | 68 | g/cm2 | sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days) | 99401 | sham surgical control condition (for 28 days) | | | Aprotinin (12000 kIU) (for 28 days) | | | | |

7 | left ventricle end-systolic wall stress | SD | male | 65 | g/cm2 | sham surgical control condition (for 28 days) | 99399 | sham surgical control condition (for 28 days) | | | | | | | |

5 | left ventricle end-systolic wall stress | SD | male | 49 | g/cm2 | sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days) | 99397 | sham surgical control condition (for 2 days) | | | Aprotinin (12000 kIU) (for 2 days) | | | | |

5 | left ventricle end-systolic wall stress | SD | male | 50 | g/cm2 | sham surgical control condition (for 2 days) | 99395 | sham surgical control condition (for 2 days) | | | | | | | |

10 | left ventricle end-systolic wall stress | SD | male | 72 | g/cm2 | sham surgical control condition (for 105 days) | 99253 | sham surgical control condition (for 105 days) | | | | | | | |

8 | left ventricle end-systolic wall stress | SD | male | 67 | g/cm2 | sham surgical control condition (for 28 days) | 99251 | sham surgical control condition (for 28 days) | | | | | | | |

10 | metastatic lung tumor number | WAG/RijCrl | male | 28.5 | | S4MH cells (250 X 10E3) (for 21 days) then sham surgical control condition (for 11 days) | 108162 | S4MH cells (250 X 10E3) (for 21 days) | | | sham surgical control condition (for 11 days) | | | | |

7 | ratio of the area occupied by interstitial collagen to the total area of the heart left ventricle | SD | male | 3.5 | % | sham surgical control condition (for 28 days) | 99407 | sham surgical control condition (for 28 days) | | | | | | | |

5 | ratio of the area occupied by interstitial collagen to the total area of the heart left ventricle | SD | male | 4 | % | sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days) | 99405 | sham surgical control condition (for 2 days) | | | Aprotinin (12000 kIU) (for 2 days) | | | | |

5 | ratio of the area occupied by interstitial collagen to the total area of the heart left ventricle | SD | male | 3.9 | % | sham surgical control condition (for 2 days) | 99403 | sham surgical control condition (for 2 days) | | | | | | | |

7 | heart left ventricle end-diastolic diameter to posterior wall thickness ratio | SD | male | 4.5 | | sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days) | 99361 | sham surgical control condition (for 28 days) | | | Aprotinin (12000 kIU) (for 28 days) | | | | |

7 | heart left ventricle end-diastolic diameter to posterior wall thickness ratio | SD | male | 4.2 | | sham surgical control condition (for 28 days) | 99359 | sham surgical control condition (for 28 days) | | | | | | | |

5 | heart left ventricle end-diastolic diameter to posterior wall thickness ratio | SD | male | 4.6 | | sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days) | 99357 | sham surgical control condition (for 2 days) | | | Aprotinin (12000 kIU) (for 2 days) | | | | |

5 | heart left ventricle end-diastolic diameter to posterior wall thickness ratio | SD | male | 4.6 | | sham surgical control condition (for 2 days) | 99355 | sham surgical control condition (for 2 days) | | | | | | | |

10 | heart left ventricle end-diastolic diameter to posterior wall thickness ratio | SD | male | 5.9 | | sham surgical control condition (for 105 days) | 99245 | sham surgical control condition (for 105 days) | | | | | | | |

8 | heart left ventricle end-diastolic diameter to posterior wall thickness ratio | SD | male | 4.8 | | sham surgical control condition (for 28 days) | 99243 | sham surgical control condition (for 28 days) | | | | | | | |

6 | heart left ventricle end-diastolic diameter to posterior wall thickness ratio | SD | male | 4.4 | | sham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98873 | sham surgical control condition (between 120 and 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

6 | heart left ventricle end-diastolic diameter to posterior wall thickness ratio | SD | male | 4.6 | | sham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98871 | sham surgical control condition (for 2 days) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | | | |

6 | heart left ventricle end-diastolic diameter to posterior wall thickness ratio | SD | male | 4.5 | | sham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) | 98869 | sham surgical control condition (for 12 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) | | | |

6 | heart left ventricle end-diastolic diameter to posterior wall thickness ratio | SD | male | 4.4 | | sham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours) | 98867 | sham surgical control condition (for 6 hours) | | | ketamine (80 mg/kg) (for 0 hours) | xylazine (10 mg/kg) (for 0 hours) | | | |

8 | plasma bradykinin level | SD | male | 17 | pg/ml | sham surgical control condition (for 105 days) | 99281 | sham surgical control condition (for 105 days) | | | | | | | |

8 | plasma bradykinin level | SD | male | 10 | pg/ml | sham surgical control condition (for 28 days) | 99279 | sham surgical control condition (for 28 days) | | | | | | | |

8 | heart left ventricle interstitial bradykinin level during a period of time | SD | male | 7.4 | pg/hr | sham surgical control condition (for 105 days) | 99265 | sham surgical control condition (for 105 days) | | | | | | | |

8 | heart left ventricle interstitial bradykinin level during a period of time | SD | male | 6.4 | pg/hr | sham surgical control condition (for 28 days) | 99263 | sham surgical control condition (for 28 days) | | | | | | | |

8 | heart left ventricle interstitial norepinephrine level during a period of time | SD | male | 5.9 | pg/hr | sham surgical control condition (for 105 days) | 99269 | sham surgical control condition (for 105 days) | | | | | | | |

8 | heart left ventricle interstitial norepinephrine level during a period of time | SD | male | 6.2 | pg/hr | sham surgical control condition (for 28 days) | 99267 | sham surgical control condition (for 28 days) | | | | | | | |

8 | heart left ventricle interstitial angiotensin II level during a period of time | SD | male | 1.6 | pg/hr | sham surgical control condition (for 105 days) | 99261 | sham surgical control condition (for 105 days) | | | | | | | |

8 | heart left ventricle interstitial angiotensin II level during a period of time | SD | male | 1.5 | pg/hr | sham surgical control condition (for 28 days) | 99259 | sham surgical control condition (for 28 days) | | | | | | | |

8 | heart left ventricle interstitial epinephrine level during a period of time | SD | male | 3.5 | pg/hr | sham surgical control condition (for 105 days) | 99273 | sham surgical control condition (for 105 days) | | | | | | | |

8 | heart left ventricle interstitial epinephrine level during a period of time | SD | male | 3.5 | pg/hr | sham surgical control condition (for 28 days) | 99271 | sham surgical control condition (for 28 days) | | | | | | | |

6 | heart right atrium weight to body weight ratio | SD | male | 0.08 | mg/g | sham surgical control condition (for 140 days) | 101122 | sham surgical control condition (for 140 days) | | | | | | | |

6 | heart right atrium weight to body weight ratio | SD | male | 0.1 | mg/g | sham surgical control condition (for 28 days) | 101120 | sham surgical control condition (for 28 days) | | | | | | | |

6 | heart left atrium weight to body weight ratio | SD | male | 0.08 | mg/g | sham surgical control condition (for 140 days) | 101114 | sham surgical control condition (for 140 days) | | | | | | | |

6 | heart left atrium weight to body weight ratio | SD | male | 0.07 | mg/g | sham surgical control condition (for 28 days) | 101112 | sham surgical control condition (for 28 days) | | | | | | | |

8 | partial pressure of brain white matter oxygen | SHRSP/A3NCrl | male | 15.4 | mmHg | sham surgical control condition then standard diet | 107324 | sham surgical control condition | | | standard diet | | | | |

8 | partial pressure of brain white matter oxygen | SHRSP/A3NCrl | male | 16.8 | mmHg | sham surgical control condition then standard diet | 107323 | sham surgical control condition | | | standard diet | | | | |

8 | partial pressure of brain white matter oxygen | SHRSP/A3NCrl | male | 18 | mmHg | sham surgical control condition then standard diet | 107322 | sham surgical control condition | | | standard diet | | | | |

8 | partial pressure of brain white matter oxygen | SHRSP/A3NCrl | male | 19.7 | mmHg | sham surgical control condition then standard diet | 107320 | sham surgical control condition | | | standard diet | | | | |

8 | partial pressure of brain white matter oxygen | SHRSP/A3NCrl | male | 41.8 | mmHg | sham surgical control condition then standard diet | 107319 | sham surgical control condition | | | standard diet | | | | |

6 | heart septum weight | SD | male | 0.29 | g | sham surgical control condition (for 140 days) | 101126 | sham surgical control condition (for 140 days) | | | | | | | |

6 | heart septum weight | SD | male | 0.23 | g | sham surgical control condition (for 28 days) | 101124 | sham surgical control condition (for 28 days) | | | | | | | |

6 | plasma osmolality | SS/Hsd | male | 299.4 | umol/g | controlled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days) | 102263 | controlled sodium content diet (8 %) (for 21 days) | | | intracerebroventricular cannula implantation | | scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) | | sham surgical control condition (for 21 days) |

6 | plasma osmolality | SS/Hsd | male | 301.4 | umol/g | controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days) | 102261 | controlled sodium content diet (0.4 %) (for 21 days) | | | intracerebroventricular cannula implantation | | scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) | | sham surgical control condition (for 21 days) |

6 | plasma osmolality | SR/Hsd | male | 298.7 | umol/g | controlled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days) | 102259 | controlled sodium content diet (8 %) (for 21 days) | | | intracerebroventricular cannula implantation | | scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) | | sham surgical control condition (for 21 days) |

6 | plasma osmolality | SR/Hsd | male | 298.6 | umol/g | controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days) | 102257 | controlled sodium content diet (0.4 %) (for 21 days) | | | intracerebroventricular cannula implantation | | scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) | | sham surgical control condition (for 21 days) |

6 | adrenal gland renin level | SD | male | 2.2 | ng/ml/h | sham surgical control condition (between 12 and 14 days) | 101567 | sham surgical control condition (between 12 and 14 days) | | | | | | | |

10 | number of large metastatic liver tumors | WAG/RijCrl | male | 3.3 | | S4MH cells (250 X 10E3) (for 21 days) then sham surgical control condition (for 11 days) | 108154 | S4MH cells (250 X 10E3) (for 21 days) | | | sham surgical control condition (for 11 days) | | | | |

10 | metastatic liver tumor number | WAG/RijCrl | male | 9.3 | | S4MH cells (250 X 10E3) (for 21 days) then sham surgical control condition (for 11 days) | 108155 | S4MH cells (250 X 10E3) (for 21 days) | | | sham surgical control condition (for 11 days) | | | | |

10 | number of small metastatic liver tumors | WAG/RijCrl | male | 1.7 | | S4MH cells (250 X 10E3) (for 21 days) then sham surgical control condition (for 11 days) | 108152 | S4MH cells (250 X 10E3) (for 21 days) | | | sham surgical control condition (for 11 days) | | | | |

10 | number of medium-sized metastatic liver tumors | WAG/RijCrl | male | 4.3 | | S4MH cells (250 X 10E3) (for 21 days) then sham surgical control condition (for 11 days) | 108153 | S4MH cells (250 X 10E3) (for 21 days) | | | sham surgical control condition (for 11 days) | | | | |