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PhenoMiner Database Result        View data table  |  Download data table  |  View expanded data table        


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Rat Strains

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Measurement Methods

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Age

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Experimental Conditions

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# of AnimalsPhenotypeStrainSexValueUnitsConditionsRecord IDCondition 1aCondition 1bCondition 1cCondition 2aCondition 2bCondition 3aCondition 3bCondition 4
12ejection fractionWKYmale75.8%sham surgical control condition (for 196 days)100351sham surgical control condition (for 196 days)
5ejection fractionWKYmale86.8%sham surgical control condition (for 224 days)100300sham surgical control condition (for 224 days)
7ejection fractionSDmale67%sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99377sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
7ejection fractionSDmale66%sham surgical control condition (for 28 days)99375sham surgical control condition (for 28 days)
5ejection fractionSDmale72%sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99373sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5ejection fractionSDmale66%sham surgical control condition (for 2 days)99371sham surgical control condition (for 2 days)
6ejection fractionSDmale64%sham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98885sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6ejection fractionSDmale65%sham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98883sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6ejection fractionSDmale63%sham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98881sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6ejection fractionSDmale65%sham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98879sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
5left ventricular end-diastolic blood pressureWKYmale5.5mmHgsham surgical control condition (for 224 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100324sham surgical control condition (for 224 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
7left ventricular end-diastolic blood pressureSDmale4mmHgsham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99313sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
7left ventricular end-diastolic blood pressureSDmale4.2mmHgsham surgical control condition (for 28 days)99311sham surgical control condition (for 28 days)
5left ventricular end-diastolic blood pressureSDmale5mmHgsham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99309sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5left ventricular end-diastolic blood pressureSDmale6mmHgsham surgical control condition (for 2 days)99307sham surgical control condition (for 2 days)
10left ventricular end-diastolic blood pressureSDmale5mmHgsham surgical control condition (for 105 days)99225sham surgical control condition (for 105 days)
8left ventricular end-diastolic blood pressureSDmale2mmHgsham surgical control condition (for 28 days)99223sham surgical control condition (for 28 days)
6left ventricular end-diastolic blood pressureSDmale3mmHgsham surgical control condition (for 2 days) then metoprolol (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98829sham surgical control condition (for 2 days)metoprolol (100 mg/kg/d) (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-diastolic blood pressureSDmale3mmHgsham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98827sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-diastolic blood pressureSDmale2mmHgsham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98825sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6left ventricular end-diastolic blood pressureSDmale2mmHgsham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98823sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-diastolic blood pressureSDmale2mmHgsham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98821sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-diastolic blood pressureSDmale5mmHgsham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98819sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
5left ventricular end-diastolic blood pressureWKY.WKHA-(D5Rat45-D5Rat245)/Cfdfemale0.22mmHgsham surgical control condition68859sham surgical control condition
5left ventricular end-diastolic blood pressureWKHA/Cfdfemale1.99mmHgsham surgical control condition68857sham surgical control condition
5left ventricular end-diastolic blood pressureWKY/Cfdfemale1.66mmHgsham surgical control condition68808sham surgical control condition
5left ventricular end-diastolic blood pressureWKY.WKHA-(D5Rat45-D5Rat245)/Cfdmale0.52mmHgsham surgical control condition68806sham surgical control condition
5left ventricular end-diastolic blood pressureWKHA/Cfdmale0.23mmHgsham surgical control condition68804sham surgical control condition
5left ventricular end-diastolic blood pressureWKY/Cfdmale1.32mmHgsham surgical control condition68802sham surgical control condition
9right kidney wet weight to body weight ratioSHR-Chr 8MWF/Rkbmale3.36mg/gsham surgical control condition (for 126 days)109558sham surgical control condition (for 126 days)
9right kidney wet weight to body weight ratioSHR/FubRkbmale3.25mg/gsham surgical control condition (for 126 days)109557sham surgical control condition (for 126 days)
10lung wet weightWAG/RijCrlmale1.4gS4MH cells (250 X 10E3) (for 21 days) then sham surgical control condition (for 11 days)108160S4MH cells (250 X 10E3) (for 21 days)sham surgical control condition (for 11 days)
12lung wet weightWKYmale1.779gsham surgical control condition (for 196 days)100297sham surgical control condition (for 196 days)
6heart weightSDmale1.41gsham surgical control condition (for 140 days)101082sham surgical control condition (for 140 days)
6heart weightSDmale1.13gsham surgical control condition (for 28 days)101080sham surgical control condition (for 28 days)
5heart weightWKYmale1.266gsham surgical control condition (for 224 days)100279sham surgical control condition (for 224 days)
12heart weightWKYmale1.187gsham surgical control condition (for 196 days)100276sham surgical control condition (for 196 days)
10heart weightSDmale1.26gsham surgical control condition (for 105 days)99197sham surgical control condition (for 105 days)
8heart weightSDmale0.98gsham surgical control condition (for 28 days)99195sham surgical control condition (for 28 days)
10heart weight to body weight ratioSDmale2.7g/kgsham surgical control condition (for 105 days)99201sham surgical control condition (for 105 days)
8heart weight to body weight ratioSDmale2.7g/kgsham surgical control condition (for 28 days)99199sham surgical control condition (for 28 days)
6heart weight to body weight ratioSDmale3.4g/kgsham surgical control condition (between 120 and 12 hours)98784sham surgical control condition (between 120 and 12 hours)
6heart weight to body weight ratioSDmale3.3g/kgsham surgical control condition (for 2 days)98782sham surgical control condition (for 2 days)
6heart weight to body weight ratioSDmale3.4g/kgsham surgical control condition (for 12 hours)98780sham surgical control condition (for 12 hours)
6heart weight to body weight ratioSDmale3.3g/kgsham surgical control condition (for 6 hours)98778sham surgical control condition (for 6 hours)
N/Amean arterial blood pressureSS/JrHsdfemale129mmHgcontrolled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days)102210controlled sodium chloride content diet (0.4 %) (for 14 days)sham surgical control conditionpeanut oil (0.2 ml) (for 14 days)
N/Amean arterial blood pressureSR/JrHsdfemale122mmHgcontrolled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days)102207controlled sodium chloride content diet (0.4 %) (for 14 days)sham surgical control conditionpeanut oil (0.2 ml) (for 14 days)
7mean arterial blood pressureSDmale106mmHgsham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99305sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
7mean arterial blood pressureSDmale107mmHgsham surgical control condition (for 28 days)99303sham surgical control condition (for 28 days)
5mean arterial blood pressureSDmale106mmHgsham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99301sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5mean arterial blood pressureSDmale100mmHgsham surgical control condition (for 2 days)99299sham surgical control condition (for 2 days)
10mean arterial blood pressureSDmale95mmHgsham surgical control condition (for 105 days)99221sham surgical control condition (for 105 days)
8mean arterial blood pressureSDmale114mmHgsham surgical control condition (for 28 days)99219sham surgical control condition (for 28 days)
14mean arterial blood pressureCrl:WI(WU)male103mmHgsham surgical control condition100021sham surgical control condition
14mean arterial blood pressureCrl:WI(WU)male105mmHgsham surgical control condition100013sham surgical control condition
6mean arterial blood pressureSDmale82mmHgsham surgical control condition (for 2 days) then metoprolol (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98817sham surgical control condition (for 2 days)metoprolol (100 mg/kg/d) (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6mean arterial blood pressureSDmale86mmHgsham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98815sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6mean arterial blood pressureSDmale85mmHgsham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98813sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6mean arterial blood pressureSDmale76mmHgsham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98811sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6mean arterial blood pressureSDmale90mmHgsham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98809sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6mean arterial blood pressureSDmale103mmHgsham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98807sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart right ventricle weight to body weight ratioSDmale0.51mg/gsham surgical control condition (for 140 days)101106sham surgical control condition (for 140 days)
6heart right ventricle weight to body weight ratioSDmale0.59mg/gsham surgical control condition (for 28 days)101104sham surgical control condition (for 28 days)
5body weight gainMWmale23gvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101343vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
6body weight gainMWmale8glosartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101341losartan (10 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5body weight gainMWmale6gvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101339vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6body weight gainMWmale-1glosartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101337losartan (10 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6body weight gainMWmale-6gvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101335vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
6body weight gainMWmale-5glosartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101333losartan (10 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
5body weight gainMWmale34gvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101329vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5body weight gainMWmale30gramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101327ramipril (3 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5body weight gainMWmale18gvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101325vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
5body weight gainMWmale20gramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101323ramipril (3 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
7urine sodium excretion rateMWmale1.28mEq/dsham surgical control condition (for 28 days)101047sham surgical control condition (for 28 days)
6blood glucose levelGKfemale172mg/dlsham surgical control condition (for 24 days) then fasting (for 12 hours)103759sham surgical control condition (for 24 days)fasting (for 12 hours)
6blood glucose levelCrl:WI(Han)female105mg/dlsham surgical control condition (for 24 days) then fasting (for 12 hours)103757sham surgical control condition (for 24 days)fasting (for 12 hours)
6heart weight to body weight ratioSDmale2.66g/kgsham surgical control condition (for 140 days)101086sham surgical control condition (for 140 days)
6heart weight to body weight ratioSDmale2.92g/kgsham surgical control condition (for 28 days)101084sham surgical control condition (for 28 days)
6heart weight to body weight ratioGKfemale4g/kgsham surgical control condition (for 24 days)103779sham surgical control condition (for 24 days)
6heart weight to body weight ratioCrl:WI(Han)female3.2g/kgsham surgical control condition (for 24 days)103777sham surgical control condition (for 24 days)
6heart left ventricle weight to body weight ratioSDmale1.44mg/gsham surgical control condition (for 140 days)101098sham surgical control condition (for 140 days)
6heart left ventricle weight to body weight ratioSDmale1.56mg/gsham surgical control condition (for 28 days)101096sham surgical control condition (for 28 days)
9right kidney wet weightSHR-Chr 8MWF/Rkbmale1.16gsham surgical control condition (for 126 days)109554sham surgical control condition (for 126 days)
9right kidney wet weightSHR/FubRkbmale1.07gsham surgical control condition (for 126 days)109553sham surgical control condition (for 126 days)
12right kidney wet weightWKYmale1.378gsham surgical control condition (for 196 days)100371sham surgical control condition (for 196 days)
12right kidney wet weightWKYmale1.378gsham surgical control condition (for 196 days)100357sham surgical control condition (for 196 days)
6systolic blood pressureSDmale118mmHgsham surgical control condition (for 28 days)101583sham surgical control condition (for 28 days)
6systolic blood pressureSDmale118mmHgsham surgical control condition (between 12 and 14 days)101547sham surgical control condition (between 12 and 14 days)
6systolic blood pressureSDmale144mmHgsham surgical control condition (for 140 days)101090sham surgical control condition (for 140 days)
6systolic blood pressureSDmale134mmHgsham surgical control condition (for 28 days)101088sham surgical control condition (for 28 days)
5systolic blood pressureWKYmale97.8mmHgsham surgical control condition (for 224 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100315sham surgical control condition (for 224 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
5systolic blood pressureMWmale165mmHgvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101365vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
6systolic blood pressureMWmale130mmHglosartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101363losartan (10 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5systolic blood pressureMWmale160mmHgvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101361vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6systolic blood pressureMWmale143mmHglosartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101359losartan (10 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6systolic blood pressureMWmale150mmHgvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101357vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
5systolic blood pressureMWmale151mmHglosartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101355losartan (10 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
5systolic blood pressureMWmale130mmHgvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101351vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5systolic blood pressureMWmale129mmHgramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101349ramipril (3 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5systolic blood pressureMWmale123mmHgvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101347vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
5systolic blood pressureMWmale106mmHgramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101345ramipril (3 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
8both kidneys wet weight to body weight ratioSBH/Yglmale2.6g/kgsham surgical control condition (for 56 days) and water (for 56 days) and standard rat chow (for 56 days)106649sham surgical control condition (for 56 days)water (for 56 days)standard rat chow (for 56 days)
8both kidneys wet weight to body weight ratioSBN/Yglmale2.4g/kgsham surgical control condition (for 56 days) and water (for 56 days) and standard rat chow (for 56 days)106646sham surgical control condition (for 56 days)water (for 56 days)standard rat chow (for 56 days)
6plasma creatinine levelWKYmale0.41mg/dlsham surgical control condition (for 196 days)100377sham surgical control condition (for 196 days)
6plasma creatinine levelWKYmale0.41mg/dlsham surgical control condition (for 196 days)100363sham surgical control condition (for 196 days)
10urine albumin excretion rateSHR-Chr 6MWF/Rkbmale0.5mg/dsham surgical control condition108127sham surgical control condition
10urine albumin excretion rateSHR-Chr 6MWF/Rkbmale1.3mg/dsham surgical control condition108126sham surgical control condition
10urine albumin excretion rateSHR/FubRkbmale0.4mg/dsham surgical control condition108125sham surgical control condition
10urine albumin excretion rateMWF/FubRkbmale108.7mg/dsham surgical control condition108124sham surgical control condition
10urine albumin excretion rateMWF/FubRkbmale22.8mg/dsham surgical control condition108123sham surgical control condition
9urine albumin excretion rateSHR-Chr 8MWF/Rkbmale1.3mg/dsham surgical control condition (for 42 days)109564sham surgical control condition (for 42 days)
9urine albumin excretion rateSHR-Chr 8MWF/Rkbmale10.8mg/dsham surgical control condition (for 126 days)109563sham surgical control condition (for 126 days)
9urine albumin excretion rateSHR/FubRkbmale0.4mg/dsham surgical control condition (for 42 days)109562sham surgical control condition (for 42 days)
9urine albumin excretion rateSHR/FubRkbmale1.3mg/dsham surgical control condition (for 42 days)109561sham surgical control condition (for 42 days)
6plasma total cholesterol levelGKfemale2.53mg/dlsham surgical control condition (for 24 days)103767sham surgical control condition (for 24 days)
6plasma total cholesterol levelCrl:WI(Han)female2.49mg/dlsham surgical control condition (for 24 days)103765sham surgical control condition (for 24 days)
5diastolic blood pressureWKYmale63.3mmHgsham surgical control condition (for 224 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100318sham surgical control condition (for 224 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
5serum sodium levelWKYmale157.7mmol/lsham surgical control condition (for 224 days)100330sham surgical control condition (for 224 days)
5serum potassium levelWKYmale5.3mmol/lsham surgical control condition (for 224 days)100333sham surgical control condition (for 224 days)
5heart rateWKYmale398beats/minsham surgical control condition (for 224 days)100312sham surgical control condition (for 224 days)
5heart rateMWmale382beats/minvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101388vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
6heart rateMWmale407beats/minlosartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101385losartan (10 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart rateMWmale366beats/minvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101383vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6heart rateMWmale410beats/minlosartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101381losartan (10 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6heart rateMWmale377beats/minvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101379vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
5heart rateMWmale424beats/minlosartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101377losartan (10 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
5heart rateMWmale358beats/minvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101373vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart rateMWmale402beats/minramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101371ramipril (3 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart rateMWmale406beats/minvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101369vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
5heart rateMWmale366beats/minramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101367ramipril (3 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
7heart rateSDmale312beats/minsham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99297sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
7heart rateSDmale321beats/minsham surgical control condition (for 28 days)99295sham surgical control condition (for 28 days)
5heart rateSDmale371beats/minsham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99293sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5heart rateSDmale359beats/minsham surgical control condition (for 2 days)99291sham surgical control condition (for 2 days)
10heart rateSDmale217beats/minsham surgical control condition (for 105 days)99217sham surgical control condition (for 105 days)
8heart rateSDmale260beats/minsham surgical control condition (for 28 days)99215sham surgical control condition (for 28 days)
6heart rateSDmale365beats/minsham surgical control condition (for 2 days) then metoprolol succinate (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98805sham surgical control condition (for 2 days)metoprolol succinate (100 mg/kg/d) (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart rateSDmale380beats/minsham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98802sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart rateSDmale365beats/minsham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98800sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart rateSDmale389beats/minsham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98798sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart rateSDmale395beats/minsham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98796sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart rateSDmale385beats/minsham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98794sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart wet weightSDmale1.03gsham surgical control condition (for 28 days)101587sham surgical control condition (for 28 days)
6left kidney wet weightSDmale1.19gsham surgical control condition (for 28 days)101579sham surgical control condition (for 28 days)
6left kidney wet weightSDmale1.11gsham surgical control condition (between 12 and 14 days)101543sham surgical control condition (between 12 and 14 days)
6both kidneys wet weightSR/JrHsdfemale1.57gcontrolled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days)102349controlled sodium content diet (0.1 %) (for 112 days)sham surgical control condition (between 56 and 63 days)
6both kidneys wet weightSS/JrHsdfemale1.77gcontrolled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days)102346controlled sodium content diet (0.1 %) (for 112 days)sham surgical control condition (between 56 and 63 days)
6plasma potassium levelSDmale5mmol/lsham surgical control condition (for 28 days)101595sham surgical control condition (for 28 days)
10heart left ventricle weight to body weight ratioSDmale1.9mg/gsham surgical control condition (for 105 days)99205sham surgical control condition (for 105 days)
8heart left ventricle weight to body weight ratioSDmale2.1mg/gsham surgical control condition (for 28 days)99203sham surgical control condition (for 28 days)
6heart left ventricle weight to body weight ratioSDmale2.5mg/gsham surgical control condition (for 2 days) then metoprolol succinate (100 mg/kg/d) (for 2 days)98877sham surgical control condition (for 2 days)metoprolol succinate (100 mg/kg/d) (for 2 days)
6heart left ventricle weight to body weight ratioSDmale2.3mg/gsham surgical control condition (for 2 days) then vehicle control condition (for 2 days)98875sham surgical control condition (for 2 days)vehicle control condition (for 2 days)
6heart left ventricle weight to body weight ratioSDmale2.3mg/gsham surgical control condition (between 120 and 12 hours)98792sham surgical control condition (between 120 and 12 hours)
6heart left ventricle weight to body weight ratioSDmale2.2mg/gsham surgical control condition (for 2 days)98790sham surgical control condition (for 2 days)
6heart left ventricle weight to body weight ratioSDmale2.3mg/gsham surgical control condition (for 12 hours)98788sham surgical control condition (for 12 hours)
6heart left ventricle weight to body weight ratioSDmale2.2mg/gsham surgical control condition (for 6 hours)98786sham surgical control condition (for 6 hours)
6plasma renin activity levelSDmale3.1ng/ml/hsham surgical control condition (between 12 and 14 days)101563sham surgical control condition (between 12 and 14 days)
7plasma renin activity levelMWmale9.1ng/ml/hsham surgical control condition (for 28 days)101043sham surgical control condition (for 28 days)
12heart left ventricle fractional shorteningWKYmale41.1%sham surgical control condition (for 196 days)100348sham surgical control condition (for 196 days)
5heart left ventricle fractional shorteningWKYmale51.5%sham surgical control condition (for 224 days)100303sham surgical control condition (for 224 days)
7heart left ventricle fractional shorteningSDmale38%sham surgical control condition (for 28 days)99367sham surgical control condition (for 28 days)
5heart left ventricle fractional shorteningSDmale43%sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99365sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5heart left ventricle fractional shorteningSDmale41%sham surgical control condition (for 2 days)99363sham surgical control condition (for 2 days)
10heart left ventricle fractional shorteningSDmale40%sham surgical control condition (for 105 days)99257sham surgical control condition (for 105 days)
8heart left ventricle fractional shorteningSDmale38%sham surgical control condition (for 28 days)99255sham surgical control condition (for 28 days)
5tibia lengthWKYmale4.3cmsham surgical control condition (for 224 days)100285sham surgical control condition (for 224 days)
6plasma low density lipoprotein cholesterol levelGKfemale0.23mg/dlsham surgical control condition (for 24 days)103771sham surgical control condition (for 24 days)
6plasma low density lipoprotein cholesterol levelCrl:WI(Han)female0.21mg/dlsham surgical control condition (for 24 days)103769sham surgical control condition (for 24 days)
8pituitary gland wet weightCOP/CrCrlmale0.0095gsham surgical control condition69106sham surgical control condition
7pituitary gland wet weightACI/SegHsdmale0.0081gsham surgical control condition69104sham surgical control condition
6pituitary gland wet weightCOP/CrCrlmale0.0076gsham surgical control condition69102sham surgical control condition
6pituitary gland wet weightACI/SegHsdmale0.0077gsham surgical control condition69100sham surgical control condition
10pituitary gland wet weightBN/SsNHsdfemale0.0075gsham surgical control condition (between 193 and 199 days)13099sham surgical control condition (between 193 and 199 days)
10pituitary gland wet weightACI/SegHsdfemale0.0089gsham surgical control condition (between 193 and 199 days)13090sham surgical control condition (between 193 and 199 days)
6plasma aldosterone levelSDmale50pg/mlsham surgical control condition (between 12 and 14 days)101555sham surgical control condition (between 12 and 14 days)
7heart left ventricular end-diastolic diameterSDmale7.6mmsham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99345sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
7heart left ventricular end-diastolic diameterSDmale7.7mmsham surgical control condition (for 28 days)99343sham surgical control condition (for 28 days)
5heart left ventricular end-diastolic diameterSDmale7mmsham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99341sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5heart left ventricular end-diastolic diameterSDmale6.9mmsham surgical control condition (for 2 days)99339sham surgical control condition (for 2 days)
10heart left ventricular end-diastolic diameterSDmale9mmsham surgical control condition (for 105 days)99237sham surgical control condition (for 105 days)
8heart left ventricular end-diastolic diameterSDmale7mmsham surgical control condition (for 28 days)99235sham surgical control condition (for 28 days)
6heart left ventricular end-diastolic diameterSDmale7.1mmsham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98849sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart left ventricular end-diastolic diameterSDmale7.1mmsham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98847sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricular end-diastolic diameterSDmale7.3mmsham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98845sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricular end-diastolic diameterSDmale7.2mmsham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98843sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
7heart left ventricle end-systolic diameterSDmale4.7mmsham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99353sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
7heart left ventricle end-systolic diameterSDmale4.7mmsham surgical control condition (for 28 days)99351sham surgical control condition (for 28 days)
5heart left ventricle end-systolic diameterSDmale4.1mmsham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99349sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5heart left ventricle end-systolic diameterSDmale4mmsham surgical control condition (for 2 days)99347sham surgical control condition (for 2 days)
10heart left ventricle end-systolic diameterSDmale5.6mmsham surgical control condition (for 105 days)99241sham surgical control condition (for 105 days)
8heart left ventricle end-systolic diameterSDmale4.3mmsham surgical control condition (for 28 days)99239sham surgical control condition (for 28 days)
6heart left ventricle end-systolic diameterSDmale3.9mmsham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98857sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart left ventricle end-systolic diameterSDmale4mmsham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98855sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-systolic diameterSDmale3.8mmsham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98853sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-systolic diameterSDmale4.2mmsham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98851sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
8plasma epinephrine levelSDmale75pg/mlsham surgical control condition (for 105 days)99289sham surgical control condition (for 105 days)
8plasma epinephrine levelSDmale83pg/mlsham surgical control condition (for 28 days)99287sham surgical control condition (for 28 days)
8plasma norepinephrine levelSDmale102pg/mlsham surgical control condition (for 105 days)99285sham surgical control condition (for 105 days)
8plasma norepinephrine levelSDmale93pg/mlsham surgical control condition (for 28 days)99283sham surgical control condition (for 28 days)
6plasma insulin levelGKfemale26mU/lsham surgical control condition (for 24 days)103763sham surgical control condition (for 24 days)
6plasma insulin levelCrl:WI(Han)female221mU/lsham surgical control condition (for 24 days)103761sham surgical control condition (for 24 days)
9body weightSHR-Chr 8MWF/Rkbmale345gsham surgical control condition (for 126 days)109551sham surgical control condition (for 126 days)
9body weightSHR/FubRkbmale329.2gsham surgical control condition (for 126 days)109549sham surgical control condition (for 126 days)
8body weightSBH/Yglmale359gsham surgical control condition (for 56 days) and water (for 56 days) and standard rat chow (for 56 days)106643sham surgical control condition (for 56 days)water (for 56 days)standard rat chow (for 56 days)
8body weightSBN/Yglmale328gsham surgical control condition (for 56 days) and water (for 56 days) and standard rat chow (for 56 days)106640sham surgical control condition (for 56 days)water (for 56 days)standard rat chow (for 56 days)
6body weightSR/JrHsdfemale253.5gcontrolled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days)102343controlled sodium content diet (0.1 %) (for 112 days)sham surgical control condition (between 56 and 63 days)
6body weightSS/JrHsdfemale281.5gcontrolled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days)102340controlled sodium content diet (0.1 %) (for 112 days)sham surgical control condition (between 56 and 63 days)
6body weightSDmale347gsham surgical control condition (for 28 days)101571sham surgical control condition (for 28 days)
6body weightSDmale336gsham surgical control condition (between 12 and 14 days)101535sham surgical control condition (between 12 and 14 days)
6body weightSDmale532.2gsham surgical control condition (for 140 days)101078sham surgical control condition (for 140 days)
6body weightSDmale378.1gsham surgical control condition (for 28 days)101076sham surgical control condition (for 28 days)
5body weightWKYmale562gsham surgical control condition (for 224 days)100273sham surgical control condition (for 224 days)
12body weightWKYmale566gsham surgical control condition (for 196 days)100270sham surgical control condition (for 196 days)
12body weightWKYmale223gsham surgical control condition100267sham surgical control condition
N/Abody weightSS/JrHsdfemale235gcontrolled sodium chloride content diet (4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days)102190controlled sodium chloride content diet (4 %) (for 14 days)sham surgical control conditionpeanut oil (0.2 ml) (for 14 days)
N/Abody weightSS/JrHsdfemale252gcontrolled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days)102189controlled sodium chloride content diet (0.4 %) (for 14 days)sham surgical control conditionpeanut oil (0.2 ml) (for 14 days)
N/Abody weightSR/JrHsdfemale232gcontrolled sodium chloride content diet (4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days)102184controlled sodium chloride content diet (4 %) (for 14 days)sham surgical control conditionpeanut oil (0.2 ml) (for 14 days)
N/Abody weightSR/JrHsdfemale226gcontrolled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days)102183controlled sodium chloride content diet (0.4 %) (for 14 days)sham surgical control conditionpeanut oil (0.2 ml) (for 14 days)
6body weightMWmale201gvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101321vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
6body weightMWmale204glosartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101319losartan (10 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5body weightMWmale192gvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101317vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6body weightMWmale184glosartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101315losartan (10 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6body weightMWmale200gvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101313vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
6body weightMWmale190glosartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101311losartan (10 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
5body weightMWmale180gvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101307vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5body weightMWmale186gramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101305ramipril (3 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5body weightMWmale188gvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101303vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
5body weightMWmale193gramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101301ramipril (3 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
10body weightSDmale471gsham surgical control condition (for 105 days)99193sham surgical control condition (for 105 days)
8body weightSDmale359gsham surgical control condition (for 28 days)99191sham surgical control condition (for 28 days)
6body weightGKfemale229gsham surgical control condition (for 24 days)103755sham surgical control condition (for 24 days)
6body weightCrl:WI(Han)female292gsham surgical control condition (for 24 days)102930sham surgical control condition (for 24 days)
14body weightCrl:WI(WU)male334gsham surgical control condition100005sham surgical control condition
6body weightSDmale284gsham surgical control condition (between 120 and 12 hours)98776sham surgical control condition (between 120 and 12 hours)
6body weightSDmale282gsham surgical control condition (for 2 days)98774sham surgical control condition (for 2 days)
6body weightSDmale271gsham surgical control condition (for 12 hours)98772sham surgical control condition (for 12 hours)
6body weightSDmale291gsham surgical control condition (for 6 hours)98756sham surgical control condition (for 6 hours)
5left ventricular end-systolic blood pressureWKYmale93mmHgsham surgical control condition (for 224 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100321sham surgical control condition (for 224 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
7left ventricular end-systolic blood pressureSDmale86mmHgsham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99321sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
7left ventricular end-systolic blood pressureSDmale85mmHgsham surgical control condition (for 28 days)99319sham surgical control condition (for 28 days)
5left ventricular end-systolic blood pressureSDmale58mmHgsham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99317sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5left ventricular end-systolic blood pressureSDmale55mmHgsham surgical control condition (for 2 days)99315sham surgical control condition (for 2 days)
6left ventricular end-systolic blood pressureSDmale64mmHgsham surgical control condition (for 2 days) then metoprolol (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98841sham surgical control condition (for 2 days)metoprolol (100 mg/kg/d) (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-systolic blood pressureSDmale64mmHgsham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98839sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-systolic blood pressureSDmale58mmHgsham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98837sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6left ventricular end-systolic blood pressureSDmale66mmHgsham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98835sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-systolic blood pressureSDmale62mmHgsham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98833sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6left ventricular end-systolic blood pressureSDmale58mmHgsham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98831sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
5left ventricular end-systolic blood pressureWKY.WKHA-(D5Rat45-D5Rat245)/Cfdfemale120.3mmHgsham surgical control condition68872sham surgical control condition
5left ventricular end-systolic blood pressureWKHA/Cfdfemale131mmHgsham surgical control condition68869sham surgical control condition
5left ventricular end-systolic blood pressureWKY/Cfdfemale129.7mmHgsham surgical control condition68867sham surgical control condition
5left ventricular end-systolic blood pressureWKY.WKHA-(D5Rat45-D5Rat245)/Cfdmale139.9mmHgsham surgical control condition68865sham surgical control condition
5left ventricular end-systolic blood pressureWKHA/Cfdmale126mmHgsham surgical control condition68863sham surgical control condition
5left ventricular end-systolic blood pressureWKY/Cfdmale125.3mmHgsham surgical control condition68861sham surgical control condition
6kidney sclerotic glomeruli count to total glomeruli count ratioSDmale1.9%sham surgical control condition (for 28 days)101603sham surgical control condition (for 28 days)
6urine protein excretion rateSDmale19mg/dsham surgical control condition (for 28 days)101591sham surgical control condition (for 28 days)
6urine protein excretion rateSDmale10mg/dsham surgical control condition (between 12 and 14 days)101551sham surgical control condition (between 12 and 14 days)
12heart ventricle septal wall thicknessWKYmale0.14cmsham surgical control condition (for 196 days)100336sham surgical control condition (for 196 days)
5heart weight to tibia length ratioWKYmale0.278g/cmsham surgical control condition (for 224 days)100282sham surgical control condition (for 224 days)
6change in body weightSDmale99gsham surgical control condition (for 28 days)101575sham surgical control condition (for 28 days)
6change in body weightSDmale84gsham surgical control condition (between 12 and 14 days)101539sham surgical control condition (between 12 and 14 days)
7timed urine volumeWKYmale13.9ml/dsham surgical control condition (for 196 days)100374sham surgical control condition (for 196 days)
7timed urine volumeWKYmale13.9ml/dsham surgical control condition (for 196 days)100360sham surgical control condition (for 196 days)
12heart left ventricle end-systolic diameterWKYmale4.9mmsham surgical control condition (for 196 days)100342sham surgical control condition (for 196 days)
5heart left ventricle end-systolic diameterWKYmale3.8mmsham surgical control condition (for 224 days)100309sham surgical control condition (for 224 days)
11kidney fibrotic lesion area to total kidney area ratioWKYmale0.91%sham surgical control condition (for 196 days)100383sham surgical control condition (for 196 days)
12heart left ventricular end-diastolic diameterWKYmale8.3mmsham surgical control condition (for 196 days)100339sham surgical control condition (for 196 days)
5heart left ventricular end-diastolic diameterWKYmale7.9mmsham surgical control condition (for 224 days)100306sham surgical control condition (for 224 days)
5time constant of left ventricular pressure decayWKY.WKHA-(D5Rat45-D5Rat245)/Cfdfemale7.5mssham surgical control condition68924sham surgical control condition
5time constant of left ventricular pressure decayWKHA/Cfdfemale13.5mssham surgical control condition68922sham surgical control condition
5time constant of left ventricular pressure decayWKY/Cfdfemale11.1mssham surgical control condition68920sham surgical control condition
5time constant of left ventricular pressure decayWKY.WKHA-(D5Rat45-D5Rat245)/Cfdmale7.5mssham surgical control condition68918sham surgical control condition
5time constant of left ventricular pressure decayWKHA/Cfdmale13.3mssham surgical control condition68916sham surgical control condition
5time constant of left ventricular pressure decayWKY/Cfdmale18.6mssham surgical control condition68914sham surgical control condition
5maximum rate of positive change in left ventricular blood pressureWKYmale4225mmHg/ssham surgical control condition (for 224 days) then ketamine (80 mg/kg) then xylazine (10 mg/kg) 100327sham surgical control condition (for 224 days)ketamine (80 mg/kg) xylazine (10 mg/kg)
7maximum rate of positive change in left ventricular blood pressureSDmale7931mmHg/ssham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99329sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
7maximum rate of positive change in left ventricular blood pressureSDmale8505mmHg/ssham surgical control condition (for 28 days)99327sham surgical control condition (for 28 days)
5maximum rate of positive change in left ventricular blood pressureSDmale8301mmHg/ssham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99325sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5maximum rate of positive change in left ventricular blood pressureSDmale8767mmHg/ssham surgical control condition (for 2 days)99323sham surgical control condition (for 2 days)
10maximum rate of positive change in left ventricular blood pressureSDmale7529mmHg/ssham surgical control condition (for 105 days)99229sham surgical control condition (for 105 days)
8maximum rate of positive change in left ventricular blood pressureSDmale8031mmHg/ssham surgical control condition (for 28 days)99227sham surgical control condition (for 28 days)
6maximum rate of positive change in left ventricular blood pressureSDmale7985mmHg/ssham surgical control condition (for 2 days) then metoprolol (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98889sham surgical control condition (for 2 days)metoprolol (100 mg/kg/d) (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6maximum rate of positive change in left ventricular blood pressureSDmale8231mmHg/ssham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98887sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
5maximum rate of positive change in left ventricular blood pressureWKY.WKHA-(D5Rat45-D5Rat245)/Cfdfemale9210mmHg/ssham surgical control condition68900sham surgical control condition
5maximum rate of positive change in left ventricular blood pressureWKHA/Cfdfemale10484mmHg/ssham surgical control condition68898sham surgical control condition
5maximum rate of positive change in left ventricular blood pressureWKY/Cfdfemale10672mmHg/ssham surgical control condition68896sham surgical control condition
5maximum rate of positive change in left ventricular blood pressureWKY.WKHA-(D5Rat45-D5Rat245)/Cfdmale10888mmHg/ssham surgical control condition68894sham surgical control condition
5maximum rate of positive change in left ventricular blood pressureWKHA/Cfdmale9127mmHg/ssham surgical control condition68892sham surgical control condition
5maximum rate of positive change in left ventricular blood pressureWKY/Cfdmale9876mmHg/ssham surgical control condition68890sham surgical control condition
7maximum rate of negative change in left ventricular blood pressureSDmale-7422mmHg/ssham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99336sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
7maximum rate of negative change in left ventricular blood pressureSDmale-7379mmHg/ssham surgical control condition (for 28 days)99335sham surgical control condition (for 28 days)
5maximum rate of negative change in left ventricular blood pressureSDmale-8474mmHg/ssham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99333sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5maximum rate of negative change in left ventricular blood pressureSDmale-7474mmHg/ssham surgical control condition (for 2 days)99331sham surgical control condition (for 2 days)
10maximum rate of negative change in left ventricular blood pressureSDmale-5401mmHg/ssham surgical control condition (for 105 days)99233sham surgical control condition (for 105 days)
8maximum rate of negative change in left ventricular blood pressureSDmale-7479mmHg/ssham surgical control condition (for 28 days)99231sham surgical control condition (for 28 days)
6maximum rate of negative change in left ventricular blood pressureSDmale-7212mmHg/ssham surgical control condition (for 2 days) then metoprolol succinate (100 mg/kg/d) (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98893sham surgical control condition (for 2 days)metoprolol succinate (100 mg/kg/d) (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6maximum rate of negative change in left ventricular blood pressureSDmale-7197mmHg/ssham surgical control condition (for 2 days) then vehicle control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98891sham surgical control condition (for 2 days)vehicle control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
5maximum rate of negative change in left ventricular blood pressureWKY.WKHA-(D5Rat45-D5Rat245)/Cfdfemale6589mmHg/ssham surgical control condition68912sham surgical control condition
5maximum rate of negative change in left ventricular blood pressureWKHA/Cfdfemale6612mmHg/ssham surgical control condition68910sham surgical control condition
5maximum rate of negative change in left ventricular blood pressureWKY/Cfdfemale7503mmHg/ssham surgical control condition68908sham surgical control condition
5maximum rate of negative change in left ventricular blood pressureWKY.WKHA-(D5Rat45-D5Rat245)/Cfdmale7570mmHg/ssham surgical control condition68906sham surgical control condition
5maximum rate of negative change in left ventricular blood pressureWKHA/Cfdmale5901mmHg/ssham surgical control condition68904sham surgical control condition
5maximum rate of negative change in left ventricular blood pressureWKY/Cfdmale6808mmHg/ssham surgical control condition68902sham surgical control condition
10binary logarithm of pituitary gland wet weightACI/SegHsdfemale3.13sham surgical control condition (between 193 and 199 days)65771sham surgical control condition (between 193 and 199 days)
10binary logarithm of pituitary gland wet weightBN/SsNHsdfemale2.89sham surgical control condition (between 193 and 199 days)65769sham surgical control condition (between 193 and 199 days)
6plasma sodium levelSS/Hsdmale138.9mmol/lcontrolled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days)102255controlled sodium content diet (8 %) (for 21 days)intracerebroventricular cannula implantationscrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days)sham surgical control condition (for 21 days)
6plasma sodium levelSS/Hsdmale140.3mmol/lcontrolled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days)102253controlled sodium content diet (0.4 %) (for 21 days)intracerebroventricular cannula implantationscrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days)sham surgical control condition (for 21 days)
6plasma sodium levelSR/Hsdmale139.8mmol/lcontrolled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days)102251controlled sodium content diet (8 %) (for 21 days)intracerebroventricular cannula implantationscrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days)sham surgical control condition (for 21 days)
6plasma sodium levelSR/Hsdmale140.8mmol/lcontrolled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days)102249controlled sodium content diet (0.4 %) (for 21 days)intracerebroventricular cannula implantationscrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days)sham surgical control condition (for 21 days)
12heart posterior wall thicknessWKYmale0.17cmsham surgical control condition (for 196 days)100345sham surgical control condition (for 196 days)
11index of glomerular damageWKYmale1.39sham surgical control condition (for 196 days)100366sham surgical control condition (for 196 days)
6adrenal gland weightSDmale46mgsham surgical control condition (for 28 days)101599sham surgical control condition (for 28 days)
6adrenal gland weightSDmale51mgsham surgical control condition (between 12 and 14 days)101559sham surgical control condition (between 12 and 14 days)
N/Asingle kidney wet weightSS/JrHsdfemale1.26gcontrolled sodium chloride content diet (4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days)102202controlled sodium chloride content diet (4 %) (for 14 days)sham surgical control conditionpeanut oil (0.2 ml) (for 14 days)
N/Asingle kidney wet weightSS/JrHsdfemale0.87gcontrolled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days)102201controlled sodium chloride content diet (0.4 %) (for 14 days)sham surgical control conditionpeanut oil (0.2 ml) (for 14 days)
N/Asingle kidney wet weightSR/JrHsdfemale1.05gcontrolled sodium chloride content diet (4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days)102196controlled sodium chloride content diet (4 %) (for 14 days)sham surgical control conditionpeanut oil (0.2 ml) (for 14 days)
N/Asingle kidney wet weightSR/JrHsdfemale0.86gcontrolled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days)102195controlled sodium chloride content diet (0.4 %) (for 14 days)sham surgical control conditionpeanut oil (0.2 ml) (for 14 days)
6heart left ventricle end-diastolic posterior wall thicknessSDmale1.6mmsham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98865sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart left ventricle end-diastolic posterior wall thicknessSDmale1.6mmsham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98863sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-diastolic posterior wall thicknessSDmale1.6mmsham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98861sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-diastolic posterior wall thicknessSDmale1.6mmsham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98859sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
5heart left ventricle weight to tibia length ratioWKYmale0.194g/cmsham surgical control condition (for 224 days)100294sham surgical control condition (for 224 days)
11artery tunica media width to artery inner diameter ratioWKYmale1.89sham surgical control condition (for 196 days)100386sham surgical control condition (for 196 days)
12E/A wave ratioWKYmale1.39sham surgical control condition (for 196 days)100354sham surgical control condition (for 196 days)
9plasma cystatin C levelSHR-Chr 8MWF/Rkbmale0.05mg/lsham surgical control condition (for 126 days)109568sham surgical control condition (for 126 days)
9plasma cystatin C levelSHR/FubRkbmale0.05mg/lsham surgical control condition (for 126 days)109566sham surgical control condition (for 126 days)
14plasma angiotensin I converting enzyme activity levelCrl:WI(WU)male62.2nmol/min/mLsham surgical control condition100029sham surgical control condition
6heart left ventricle weightSDmale0.76gsham surgical control condition (for 140 days)101094sham surgical control condition (for 140 days)
6heart left ventricle weightSDmale0.6gsham surgical control condition (for 28 days)101092sham surgical control condition (for 28 days)
5heart left ventricle weightWKYmale0.84gsham surgical control condition (for 224 days)100291sham surgical control condition (for 224 days)
12heart left ventricle weightWKYmale0.847gsham surgical control condition (for 196 days)100288sham surgical control condition (for 196 days)
6heart left ventricle weightMWmale0.196gvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101409vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
6heart left ventricle weightMWmale0.195glosartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101407losartan (10 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart left ventricle weightMWmale0.214gvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101405vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6heart left ventricle weightMWmale0.206glosartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101403losartan (10 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6heart left ventricle weightMWmale0.211gvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101401vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
6heart left ventricle weightMWmale0.208glosartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101399losartan (10 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
5heart left ventricle weightMWmale0.214gvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101395vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart left ventricle weightMWmale0.204gramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101393ramipril (3 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart left ventricle weightMWmale0.22gvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101391vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
5heart left ventricle weightMWmale0.194gramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101389ramipril (3 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
5heart left ventricle weightMWmale0.061gvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101413vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6heart right ventricle weightSDmale0.27gsham surgical control condition (for 140 days)101102sham surgical control condition (for 140 days)
6heart right ventricle weightSDmale0.23gsham surgical control condition (for 28 days)101100sham surgical control condition (for 28 days)
6heart right ventricle weightMWmale0.048gvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101431vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
6heart right ventricle weightMWmale0.046glosartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101429losartan (10 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart right ventricle weightMWmale0.048gvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101427vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6heart right ventricle weightMWmale0.053glosartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101425losartan (10 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6heart right ventricle weightMWmale0.054gvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101423vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
6heart right ventricle weightMWmale0.054glosartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101421losartan (10 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
5heart right ventricle weightMWmale0.061gvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101417vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart right ventricle weightMWmale0.06gramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101415ramipril (3 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart right ventricle weightMWmale0.059gramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101411ramipril (3 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6left atrium weightSDmale0.04gsham surgical control condition (for 140 days)101110sham surgical control condition (for 140 days)
6left atrium weightSDmale0.03gsham surgical control condition (for 28 days)101108sham surgical control condition (for 28 days)
6right atrium weightSDmale0.04gsham surgical control condition (for 140 days)101118sham surgical control condition (for 140 days)
6right atrium weightSDmale0.04gsham surgical control condition (for 28 days)101116sham surgical control condition (for 28 days)
10heart right ventricle weight to body weight ratioSDmale0.5mg/gsham surgical control condition (for 105 days)99209sham surgical control condition (for 105 days)
8heart right ventricle weight to body weight ratioSDmale0.5mg/gsham surgical control condition (for 28 days)99207sham surgical control condition (for 28 days)
10lung weightSDmale1.97gsham surgical control condition (for 105 days)99213sham surgical control condition (for 105 days)
8lung weightSDmale1.46gsham surgical control condition (for 28 days)99211sham surgical control condition (for 28 days)
8plasma angiotensin II levelSDmale34pg/mlsham surgical control condition (for 105 days)99277sham surgical control condition (for 105 days)
8plasma angiotensin II levelSDmale29pg/mlsham surgical control condition (for 28 days)99275sham surgical control condition (for 28 days)
6uterus weightSR/JrHsdfemale0.41gcontrolled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days)102355controlled sodium content diet (0.1 %) (for 112 days)sham surgical control condition (between 56 and 63 days)
6uterus weightSS/JrHsdfemale0.44gcontrolled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days)102352controlled sodium content diet (0.1 %) (for 112 days)sham surgical control condition (between 56 and 63 days)
6plasma estradiol levelSR/JrHsdfemale17.1pg/mlcontrolled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days)102361controlled sodium content diet (0.1 %) (for 112 days)sham surgical control condition (between 56 and 63 days)
6plasma estradiol levelSS/JrHsdfemale15.7pg/mlcontrolled sodium content diet (0.1 %) (for 112 days) then sham surgical control condition (between 56 and 63 days)102358controlled sodium content diet (0.1 %) (for 112 days)sham surgical control condition (between 56 and 63 days)
6plasma estradiol levelGKfemale49.6pg/mlsham surgical control condition (for 24 days)103775sham surgical control condition (for 24 days)
6plasma estradiol levelCrl:WI(Han)female48.6pg/mlsham surgical control condition (for 24 days)103773sham surgical control condition (for 24 days)
6heart insulin-like growth factor 1 receptor mRNA levelMWmale0.32pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101453vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
6heart insulin-like growth factor 1 receptor mRNA levelMWmale0.22pmol/llosartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101451losartan (10 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart insulin-like growth factor 1 receptor mRNA levelMWmale0.37pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101449vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6heart insulin-like growth factor 1 receptor mRNA levelMWmale0.25pmol/llosartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101447losartan (10 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6heart insulin-like growth factor 1 receptor mRNA levelMWmale0.23pmol/lvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101445vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
6heart insulin-like growth factor 1 receptor mRNA levelMWmale0.2pmol/llosartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101443losartan (10 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
5heart insulin-like growth factor 1 receptor mRNA levelMWmale0.39pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101439vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart insulin-like growth factor 1 receptor mRNA levelMWmale0.33pmol/lramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101437ramipril (3 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart insulin-like growth factor 1 receptor mRNA levelMWmale0.26pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101435vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
5heart insulin-like growth factor 1 receptor mRNA levelMWmale0.31pmol/lramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101433ramipril (3 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6heart insulin-like growth factor 1 receptor mRNA levelMWmale0.65pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101498vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
6heart insulin-like growth factor 1 receptor mRNA levelMWmale0.8pmol/llosartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101496losartan (10 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart insulin-like growth factor 1 receptor mRNA levelMWmale0.79pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101494vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6heart insulin-like growth factor 1 receptor mRNA levelMWmale0.93pmol/llosartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101492losartan (10 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6heart insulin-like growth factor 1 receptor mRNA levelMWmale1pmol/lvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101489vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
6heart insulin-like growth factor 1 receptor mRNA levelMWmale0.79pmol/llosartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101487losartan (10 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
5heart insulin-like growth factor 1 receptor mRNA levelMWmale1.24pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101483vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart insulin-like growth factor 1 receptor mRNA levelMWmale0.79pmol/lramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101481ramipril (3 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart insulin-like growth factor 1 receptor mRNA levelMWmale0.85pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101479vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
5heart insulin-like growth factor 1 receptor mRNA levelMWmale0.8pmol/lramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101477ramipril (3 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6heart insulin-like growth factor 1 mRNA levelMWmale0.34pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101475vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
6heart insulin-like growth factor 1 mRNA levelMWmale0.58pmol/llosartan (10 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101473losartan (10 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart insulin-like growth factor 1 mRNA levelMWmale0.58pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101471vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6heart insulin-like growth factor 1 mRNA levelMWmale0.64pmol/llosartan (10 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101469losartan (10 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
6heart insulin-like growth factor 1 mRNA levelMWmale0.4pmol/lvehicle control condition (0 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101467vehicle control condition (0 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
6heart insulin-like growth factor 1 mRNA levelMWmale0.26pmol/llosartan (10 mg/kg/d) (for 3 days) then sham surgical control condition (for 2 days)101465losartan (10 mg/kg/d) (for 3 days)sham surgical control condition (for 2 days)
5heart insulin-like growth factor 1 mRNA levelMWmale0.59pmol/lvehicle control condition (0 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101461vehicle control condition (0 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart insulin-like growth factor 1 mRNA levelMWmale0.34pmol/lramipril (3 mg/kg/d) (for 8 days) then sham surgical control condition (for 7 days)101459ramipril (3 mg/kg/d) (for 8 days)sham surgical control condition (for 7 days)
5heart insulin-like growth factor 1 mRNA levelMWmale0.43pmol/lvehicle control condition (0 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101457vehicle control condition (0 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
5heart insulin-like growth factor 1 mRNA levelMWmale0.38pmol/lramipril (3 mg/kg/d) (for 5 days) then sham surgical control condition (for 4 days)101455ramipril (3 mg/kg/d) (for 5 days)sham surgical control condition (for 4 days)
N/Aglomerular filtration rate to kidney weight ratioSS/JrHsdfemale2.46ml/min/gcontrolled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days)102216controlled sodium chloride content diet (0.4 %) (for 14 days)sham surgical control conditionpeanut oil (0.2 ml) (for 14 days)
N/Aglomerular filtration rate to kidney weight ratioSR/JrHsdfemale2.2ml/min/gcontrolled sodium chloride content diet (0.4 %) (for 14 days) then sham surgical control condition then peanut oil (0.2 ml) (for 14 days)102213controlled sodium chloride content diet (0.4 %) (for 14 days)sham surgical control conditionpeanut oil (0.2 ml) (for 14 days)
7left ventricle end-diastolic wall stressSDmale4g/cm2sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99393sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
7left ventricle end-diastolic wall stressSDmale4g/cm2sham surgical control condition (for 28 days)99391sham surgical control condition (for 28 days)
5left ventricle end-diastolic wall stressSDmale6g/cm2sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99389sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5left ventricle end-diastolic wall stressSDmale4g/cm2sham surgical control condition (for 2 days)99387sham surgical control condition (for 2 days)
10left ventricle end-diastolic wall stressSDmale7g/cm2sham surgical control condition (for 105 days)99249sham surgical control condition (for 105 days)
8left ventricle end-diastolic wall stressSDmale3g/cm2sham surgical control condition (for 28 days)99247sham surgical control condition (for 28 days)
7left ventricle end-systolic wall stressSDmale68g/cm2sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99401sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
7left ventricle end-systolic wall stressSDmale65g/cm2sham surgical control condition (for 28 days)99399sham surgical control condition (for 28 days)
5left ventricle end-systolic wall stressSDmale49g/cm2sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99397sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5left ventricle end-systolic wall stressSDmale50g/cm2sham surgical control condition (for 2 days)99395sham surgical control condition (for 2 days)
10left ventricle end-systolic wall stressSDmale72g/cm2sham surgical control condition (for 105 days)99253sham surgical control condition (for 105 days)
8left ventricle end-systolic wall stressSDmale67g/cm2sham surgical control condition (for 28 days)99251sham surgical control condition (for 28 days)
10metastatic lung tumor numberWAG/RijCrlmale28.5S4MH cells (250 X 10E3) (for 21 days) then sham surgical control condition (for 11 days)108162S4MH cells (250 X 10E3) (for 21 days)sham surgical control condition (for 11 days)
7ratio of the area occupied by interstitial collagen to the total area of the heart left ventricleSDmale3.5%sham surgical control condition (for 28 days)99407sham surgical control condition (for 28 days)
5ratio of the area occupied by interstitial collagen to the total area of the heart left ventricleSDmale4%sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99405sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5ratio of the area occupied by interstitial collagen to the total area of the heart left ventricleSDmale3.9%sham surgical control condition (for 2 days)99403sham surgical control condition (for 2 days)
7heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.5sham surgical control condition (for 28 days) then Aprotinin (12000 kIU) (for 28 days)99361sham surgical control condition (for 28 days)Aprotinin (12000 kIU) (for 28 days)
7heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.2sham surgical control condition (for 28 days)99359sham surgical control condition (for 28 days)
5heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.6sham surgical control condition (for 2 days) then Aprotinin (12000 kIU) (for 2 days)99357sham surgical control condition (for 2 days)Aprotinin (12000 kIU) (for 2 days)
5heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.6sham surgical control condition (for 2 days)99355sham surgical control condition (for 2 days)
10heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale5.9sham surgical control condition (for 105 days)99245sham surgical control condition (for 105 days)
8heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.8sham surgical control condition (for 28 days)99243sham surgical control condition (for 28 days)
6heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.4sham surgical control condition (between 120 and 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98873sham surgical control condition (between 120 and 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
6heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.6sham surgical control condition (for 2 days) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98871sham surgical control condition (for 2 days)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.5sham surgical control condition (for 12 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) 98869sham surgical control condition (for 12 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg)
6heart left ventricle end-diastolic diameter to posterior wall thickness ratioSDmale4.4sham surgical control condition (for 6 hours) then ketamine (80 mg/kg) (for 0 hours) and xylazine (10 mg/kg) (for 0 hours)98867sham surgical control condition (for 6 hours)ketamine (80 mg/kg) (for 0 hours)xylazine (10 mg/kg) (for 0 hours)
8plasma bradykinin levelSDmale17pg/mlsham surgical control condition (for 105 days)99281sham surgical control condition (for 105 days)
8plasma bradykinin levelSDmale10pg/mlsham surgical control condition (for 28 days)99279sham surgical control condition (for 28 days)
8heart left ventricle interstitial bradykinin level during a period of timeSDmale7.4pg/hrsham surgical control condition (for 105 days)99265sham surgical control condition (for 105 days)
8heart left ventricle interstitial bradykinin level during a period of timeSDmale6.4pg/hrsham surgical control condition (for 28 days)99263sham surgical control condition (for 28 days)
8heart left ventricle interstitial norepinephrine level during a period of timeSDmale5.9pg/hrsham surgical control condition (for 105 days)99269sham surgical control condition (for 105 days)
8heart left ventricle interstitial norepinephrine level during a period of timeSDmale6.2pg/hrsham surgical control condition (for 28 days)99267sham surgical control condition (for 28 days)
8heart left ventricle interstitial angiotensin II level during a period of timeSDmale1.6pg/hrsham surgical control condition (for 105 days)99261sham surgical control condition (for 105 days)
8heart left ventricle interstitial angiotensin II level during a period of timeSDmale1.5pg/hrsham surgical control condition (for 28 days)99259sham surgical control condition (for 28 days)
8heart left ventricle interstitial epinephrine level during a period of timeSDmale3.5pg/hrsham surgical control condition (for 105 days)99273sham surgical control condition (for 105 days)
8heart left ventricle interstitial epinephrine level during a period of timeSDmale3.5pg/hrsham surgical control condition (for 28 days)99271sham surgical control condition (for 28 days)
6heart right atrium weight to body weight ratioSDmale0.08mg/gsham surgical control condition (for 140 days)101122sham surgical control condition (for 140 days)
6heart right atrium weight to body weight ratioSDmale0.1mg/gsham surgical control condition (for 28 days)101120sham surgical control condition (for 28 days)
6heart left atrium weight to body weight ratioSDmale0.08mg/gsham surgical control condition (for 140 days)101114sham surgical control condition (for 140 days)
6heart left atrium weight to body weight ratioSDmale0.07mg/gsham surgical control condition (for 28 days)101112sham surgical control condition (for 28 days)
8partial pressure of brain white matter oxygenSHRSP/A3NCrlmale15.4mmHgsham surgical control condition then standard diet107324sham surgical control conditionstandard diet
8partial pressure of brain white matter oxygenSHRSP/A3NCrlmale16.8mmHgsham surgical control condition then standard diet107323sham surgical control conditionstandard diet
8partial pressure of brain white matter oxygenSHRSP/A3NCrlmale18mmHgsham surgical control condition then standard diet107322sham surgical control conditionstandard diet
8partial pressure of brain white matter oxygenSHRSP/A3NCrlmale19.7mmHgsham surgical control condition then standard diet107320sham surgical control conditionstandard diet
8partial pressure of brain white matter oxygenSHRSP/A3NCrlmale41.8mmHgsham surgical control condition then standard diet107319sham surgical control conditionstandard diet
6heart septum weightSDmale0.29gsham surgical control condition (for 140 days)101126sham surgical control condition (for 140 days)
6heart septum weightSDmale0.23gsham surgical control condition (for 28 days)101124sham surgical control condition (for 28 days)
6plasma osmolalitySS/Hsdmale299.4umol/gcontrolled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days)102263controlled sodium content diet (8 %) (for 21 days)intracerebroventricular cannula implantationscrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days)sham surgical control condition (for 21 days)
6plasma osmolalitySS/Hsdmale301.4umol/gcontrolled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days)102261controlled sodium content diet (0.4 %) (for 21 days)intracerebroventricular cannula implantationscrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days)sham surgical control condition (for 21 days)
6plasma osmolalitySR/Hsdmale298.7umol/gcontrolled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days)102259controlled sodium content diet (8 %) (for 21 days)intracerebroventricular cannula implantationscrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days)sham surgical control condition (for 21 days)
6plasma osmolalitySR/Hsdmale298.6umol/gcontrolled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days)102257controlled sodium content diet (0.4 %) (for 21 days)intracerebroventricular cannula implantationscrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days)sham surgical control condition (for 21 days)
6adrenal gland renin levelSDmale2.2ng/ml/hsham surgical control condition (between 12 and 14 days)101567sham surgical control condition (between 12 and 14 days)
10number of large metastatic liver tumorsWAG/RijCrlmale3.3S4MH cells (250 X 10E3) (for 21 days) then sham surgical control condition (for 11 days)108154S4MH cells (250 X 10E3) (for 21 days)sham surgical control condition (for 11 days)
10metastatic liver tumor numberWAG/RijCrlmale9.3S4MH cells (250 X 10E3) (for 21 days) then sham surgical control condition (for 11 days)108155S4MH cells (250 X 10E3) (for 21 days)sham surgical control condition (for 11 days)
10number of small metastatic liver tumorsWAG/RijCrlmale1.7S4MH cells (250 X 10E3) (for 21 days) then sham surgical control condition (for 11 days)108152S4MH cells (250 X 10E3) (for 21 days)sham surgical control condition (for 11 days)
10number of medium-sized metastatic liver tumorsWAG/RijCrlmale4.3S4MH cells (250 X 10E3) (for 21 days) then sham surgical control condition (for 11 days)108153S4MH cells (250 X 10E3) (for 21 days)sham surgical control condition (for 11 days)